BR9814729A - Método e composição de uma preparação oral de itraconazol - Google Patents

Método e composição de uma preparação oral de itraconazol

Info

Publication number
BR9814729A
BR9814729A BR9814729-3A BR9814729A BR9814729A BR 9814729 A BR9814729 A BR 9814729A BR 9814729 A BR9814729 A BR 9814729A BR 9814729 A BR9814729 A BR 9814729A
Authority
BR
Brazil
Prior art keywords
preparation
oral
composition
itraconazole
solid dispersions
Prior art date
Application number
BR9814729-3A
Other languages
English (en)
Inventor
Jae-Young Jung
Hye-Hyun Kim
Sang-Heon Lee
Ji-Woong Hong
Jong-Woo Park
Kyu-Hyun Lee
Original Assignee
Choongwae Pharma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from KR1019980027730A external-priority patent/KR100288890B1/ko
Application filed by Choongwae Pharma Corp filed Critical Choongwae Pharma Corp
Publication of BR9814729A publication Critical patent/BR9814729A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

"MéTODO E COMPOSIçãO DE UMA PREPARAçãO ORAL DE ITRACONAZOL". A presente invenção refere-se a um método e composição de uma preparação oral de itraconazol, uma excelente droga antifúngica azólica. Mais particularmente, refere-se a uma preparação oral de itraconazol tendo biodisponibilidade melhorada, que é preparada de acordo com as seguintes etapas: i). dissolver itraconazol e polímero hidrofílico com solvente; ii). secar dita mistura por pulverização, e iii) . preparar as dispersões sólidas para preparação oral. As dispersões sólidas preparadas na presente invenção podem ser úteis na preparação de comprimidos, grânulos e outras formas orais de dosagem.
BR9814729-3A 1997-12-31 1998-12-17 Método e composição de uma preparação oral de itraconazol BR9814729A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR19970081947 1997-12-31
KR1019980027730A KR100288890B1 (ko) 1997-12-31 1998-07-10 이트라코나졸 경구용 제제 및 그의 제조방법
PCT/KR1998/000436 WO1999033467A1 (en) 1997-12-31 1998-12-17 Method and composition of an oral preparation of itraconazole

Publications (1)

Publication Number Publication Date
BR9814729A true BR9814729A (pt) 2002-01-08

Family

ID=26633347

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9814729-3A BR9814729A (pt) 1997-12-31 1998-12-17 Método e composição de uma preparação oral de itraconazol

Country Status (14)

Country Link
US (1) US6485743B1 (pt)
EP (1) EP1039909B1 (pt)
JP (1) JP3696087B2 (pt)
CN (1) CN1153570C (pt)
AU (1) AU1511399A (pt)
BR (1) BR9814729A (pt)
CA (1) CA2317106C (pt)
DE (1) DE69808670T2 (pt)
ES (1) ES2185238T3 (pt)
HK (1) HK1034906A1 (pt)
PL (1) PL191181B1 (pt)
PT (1) PT1039909E (pt)
TR (1) TR200001880T2 (pt)
WO (1) WO1999033467A1 (pt)

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AU2331801A (en) * 1999-12-23 2001-07-09 F.H. Faulding & Co. Limited Improved pharmaceutical compositions for poorly soluble drugs
FR2803748A1 (fr) * 2000-01-14 2001-07-20 Ethypharm Lab Prod Ethiques Composition d'itraconazole et procede de preparation
KR20010097244A (ko) * 2000-04-21 2001-11-08 유충식 위산도 비의존성 고용해도를 갖는 이트라코나졸 함유약학적 조성물 및 그 제조방법
US8067032B2 (en) 2000-12-22 2011-11-29 Baxter International Inc. Method for preparing submicron particles of antineoplastic agents
US9700866B2 (en) 2000-12-22 2017-07-11 Baxter International Inc. Surfactant systems for delivery of organic compounds
ATE319432T1 (de) * 2000-12-22 2006-03-15 Baxter Int Verfahren zur herstellung von submikropartikel- suspensionen pharmazeutischer substanzen
WO2002100407A1 (en) * 2001-06-12 2002-12-19 Smartrix Technologies Inc. Itraconazole granulations: pharmaceutical formulations for oral administration and method of preparing same
KR100425755B1 (ko) * 2001-08-27 2004-04-03 주식회사 원진신약 이트라코나졸을 함유하는 조성물 및 그 제조방법
JP2005504090A (ja) 2001-09-26 2005-02-10 バクスター・インターナショナル・インコーポレイテッド 分散体および溶媒相または液相の除去によるサブミクロンサイズ−ナノ粒子の調製
US20060003012A9 (en) 2001-09-26 2006-01-05 Sean Brynjelsen Preparation of submicron solid particle suspensions by sonication of multiphase systems
FR2841138B1 (fr) * 2002-06-25 2005-02-25 Cll Pharma Composition pharmaceutique solide contenant un principe actif lipophile, son procede de preparation
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US20040086567A1 (en) * 2002-10-30 2004-05-06 Pawan Seth Bioequivalent composition of itraconazole and a hydrophilic polymer
ES2283725T5 (es) * 2003-01-14 2014-11-28 Acino Pharma Ag Composición bioequivalente de itraconazol dispersada en un polímero hidrófilo
JP4342426B2 (ja) * 2004-11-24 2009-10-14 科研製薬株式会社 イトラコナゾール経口投与用製剤
JP5435946B2 (ja) 2005-08-22 2014-03-05 ジョンズ ホプキンス ユニバーシティ 疾患を処置するためのヘッジホッグ経路アンタゴニスト
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WO2008135828A2 (en) 2007-05-03 2008-11-13 Pfizer Products Inc. Nanoparticles comprising a drug, ethylcellulose, and a bile salt
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US8974827B2 (en) 2007-06-04 2015-03-10 Bend Research, Inc. Nanoparticles comprising a non-ionizable cellulosic polymer and an amphiphilic non-ionizable block copolymer
WO2008149230A2 (en) 2007-06-04 2008-12-11 Pfizer Products Inc. Nanoparticles comprising drug, a non-ionizable cellulosic polymer and tocopheryl polyethylene glycol succinate
US9233078B2 (en) 2007-12-06 2016-01-12 Bend Research, Inc. Nanoparticles comprising a non-ionizable polymer and an Amine-functionalized methacrylate copolymer
EP2231169B1 (en) 2007-12-06 2016-05-04 Bend Research, Inc. Pharmaceutical compositions comprising nanoparticles and a resuspending material
KR102009698B1 (ko) 2011-12-20 2019-08-13 바이옴 테라퓨틱스 리미티드 진균 감염의 치료를 위한 국소 오일 조성물
KR20200017549A (ko) 2012-06-04 2020-02-18 파마싸이클릭스 엘엘씨 브루톤 타이로신 키나아제 저해제의 결정 형태
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JP6589086B2 (ja) * 2013-04-12 2019-10-16 ビョーメ セラピューティクス リミテッド 抗菌薬の組成物および製剤、その製造法および微生物感染症の治療方法
JP6571657B2 (ja) * 2013-08-27 2019-09-04 ボウドウリス バシリオス ベンダムスチンの薬学的組成物
WO2015134822A1 (en) * 2014-03-05 2015-09-11 Professional Compounding Centers Of America Poloxamer-based pharmaceutical compositions for treating wounds
MX2017001671A (es) * 2014-08-07 2017-07-04 Pharmacyclics Llc Formulaciones novedosas de un inhibidor de la tirosina cinasa de bruton.
CN104688536B (zh) * 2015-02-03 2016-06-08 常州制药厂有限公司 一种伊曲康唑制剂的制备方法
NZ734446A (en) 2015-03-03 2022-12-23 Pharmacyclics Llc Pharmaceutical formulations of bruton’s tyrosine kinase inhibtor
CN106511265A (zh) * 2016-11-16 2017-03-22 北京万全德众医药生物技术有限公司 一种含有伊曲康唑的口服溶液及其制备工艺
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Also Published As

Publication number Publication date
EP1039909B1 (en) 2002-10-09
PT1039909E (pt) 2003-02-28
DE69808670D1 (de) 2002-11-14
CN1153570C (zh) 2004-06-16
HK1034906A1 (en) 2001-11-09
ES2185238T3 (es) 2003-04-16
CA2317106A1 (en) 1999-07-08
WO1999033467A1 (en) 1999-07-08
JP3696087B2 (ja) 2005-09-14
PL191181B1 (pl) 2006-03-31
US6485743B1 (en) 2002-11-26
TR200001880T2 (tr) 2000-11-21
EP1039909A1 (en) 2000-10-04
CA2317106C (en) 2004-11-23
CN1285746A (zh) 2001-02-28
PL341566A1 (en) 2001-04-23
DE69808670T2 (de) 2003-07-03
AU1511399A (en) 1999-07-19
JP2001527044A (ja) 2001-12-25

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Legal Events

Date Code Title Description
B06A Notification to applicant to reply to the report for non-patentability or inadequacy of the application [chapter 6.1 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: ALTERADA DE INT.CL: A61K 31/496, A61K 47/32, A61K 9/14, A61K 9/16, A61K 9/20, A61K 9/48, A61P 31/10

Ipc: A61K 31/495 (2008.01), A61K 9/14 (2008.01)

B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements