ATE538797T1 - Pharmazeutische zusammensetzungen mit neuroaktivem steroid und verwendungen davon - Google Patents

Pharmazeutische zusammensetzungen mit neuroaktivem steroid und verwendungen davon

Info

Publication number
ATE538797T1
ATE538797T1 AT10000305T AT10000305T ATE538797T1 AT E538797 T1 ATE538797 T1 AT E538797T1 AT 10000305 T AT10000305 T AT 10000305T AT 10000305 T AT10000305 T AT 10000305T AT E538797 T1 ATE538797 T1 AT E538797T1
Authority
AT
Austria
Prior art keywords
pharmaceutical compositions
compositions containing
neuroactive steroid
pregnan
methoxymethyl
Prior art date
Application number
AT10000305T
Other languages
English (en)
Inventor
Richard M Woodward
Original Assignee
Euro Celtique Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Euro Celtique Sa filed Critical Euro Celtique Sa
Application granted granted Critical
Publication of ATE538797T1 publication Critical patent/ATE538797T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Inorganic Chemistry (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT10000305T 2005-06-09 2006-06-09 Pharmazeutische zusammensetzungen mit neuroaktivem steroid und verwendungen davon ATE538797T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US68890505P 2005-06-09 2005-06-09

Publications (1)

Publication Number Publication Date
ATE538797T1 true ATE538797T1 (de) 2012-01-15

Family

ID=36790861

Family Applications (2)

Application Number Title Priority Date Filing Date
AT06754274T ATE464054T1 (de) 2005-06-09 2006-06-09 Pharmazeutische zusammensetzung eines neuroaktiven steroids und anwendungen davon
AT10000305T ATE538797T1 (de) 2005-06-09 2006-06-09 Pharmazeutische zusammensetzungen mit neuroaktivem steroid und verwendungen davon

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT06754274T ATE464054T1 (de) 2005-06-09 2006-06-09 Pharmazeutische zusammensetzung eines neuroaktiven steroids und anwendungen davon

Country Status (25)

Country Link
US (2) US20090131383A1 (de)
EP (3) EP2263675A3 (de)
JP (2) JP2008542419A (de)
KR (3) KR20080017091A (de)
CN (1) CN101193640A (de)
AT (2) ATE464054T1 (de)
AU (1) AU2006256851C1 (de)
BR (1) BRPI0612921A2 (de)
CA (1) CA2611430C (de)
CY (2) CY1110199T1 (de)
DE (1) DE602006013622D1 (de)
DK (2) DK2168585T3 (de)
EA (1) EA013744B1 (de)
ES (2) ES2344313T3 (de)
HR (2) HRP20100372T1 (de)
IL (3) IL187813A (de)
NO (1) NO20076319L (de)
NZ (1) NZ562979A (de)
PL (2) PL1888080T3 (de)
PT (2) PT1888080E (de)
RS (2) RS51304B (de)
SI (2) SI1888080T1 (de)
UA (1) UA94909C2 (de)
WO (1) WO2006131392A1 (de)
ZA (1) ZA200709188B (de)

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CN113234114A (zh) 2011-10-14 2021-08-10 萨奇治疗股份有限公司 3,3-二取代的19-去甲孕甾烷化合物、组合物、及其用途
US20160068563A1 (en) 2013-04-17 2016-03-10 Boyd L. Harrison 19-nor neuroactive steroids and methods of use thereof
TR201901745T4 (tr) 2013-04-17 2019-03-21 Sage Therapeutics Inc 19-nor C3,3-disübstitüe edilmiş C21- n-pirazolil steroidleri ve bunların kullanım yöntemleri.
US9725481B2 (en) 2013-04-17 2017-08-08 Sage Therapeutics, Inc. 19-nor C3, 3-disubstituted C21-C-bound heteroaryl steroids and methods of use thereof
SI2986624T1 (sl) 2013-04-17 2020-10-30 Sage Therapeutics, Inc. 19-nor nevroaktivni steroidi za metode zdravljenja
PL3021852T3 (pl) 2013-07-19 2021-07-05 Sage Therapeutics, Inc. Neuroaktywne steroidy, kompozycje i ich zastosowania
PT3035940T (pt) 2013-08-23 2019-01-28 Sage Therapeutics Inc Esteroides neuroativos, composições e seus usos
US10246482B2 (en) 2014-06-18 2019-04-02 Sage Therapeutics, Inc. Neuroactive steroids, compositions, and uses thereof
PT3206493T (pt) 2014-10-16 2020-08-03 Sage Therapeutics Inc Composições e métodos para tratamento de transtornos do snc
KR20230170816A (ko) * 2014-10-16 2023-12-19 세이지 테라퓨틱스, 인크. Cns 장애의 치료를 위한 조성물 및 방법
JP6893173B2 (ja) 2014-11-27 2021-06-23 セージ セラピューティクス， インコーポレイテッド Ｃｎｓ障害を処置するための組成物および方法
HUE054092T2 (hu) 2015-01-26 2021-08-30 Sage Therapeutics Inc Központi idegrendszeri zavarok kezelésére szolgáló kompozíciók és eljárások
US10329320B2 (en) 2015-02-20 2019-06-25 Sage Therapeutics, Inc. Neuroactive steroids, compositions, and uses thereof
CA3030420C (en) 2016-07-11 2025-11-18 Sage Therapeutics, Inc. C7, C12 AND C16 SUBSTITUTED NEUROACTIVE STEROIDS AND ASSOCIATED METHODS OF USE
NZ790226A (en) 2016-07-11 2025-08-29 Sage Therapeutics Inc C17, C20, and C21 substituted neuroactive steroids and their methods of use
MX2020002652A (es) * 2017-09-07 2020-09-25 Sage Therapeutics Inc Esteroides neuroactivos y su método de uso.
US10562930B1 (en) * 2018-08-31 2020-02-18 Praxis Precision Medicines, Inc. Salts and crystal forms of GABAA positive allosteric modulator
CA3123248A1 (en) * 2018-12-14 2020-06-18 Praxis Precision Medicines, Inc. Methods for the treatment of depression
MX2021007142A (es) * 2018-12-17 2021-08-11 Intra Cellular Therapies Inc Compuestos organicos.
WO2020180955A1 (en) * 2019-03-04 2020-09-10 Praxis Precision Medicines, Inc. Methods for the treatment of perimenopause and menopause
CN114206900A (zh) 2019-05-31 2022-03-18 萨奇治疗股份有限公司 神经活性类固醇及其组合物
EP4041226A1 (de) * 2019-10-02 2022-08-17 Praxis Precision Medicines, Inc. Kombinationen von positiven allosterischen gaba-a-rezeptor-modulatoren und nmda-antagonisten, negativen allosterischen nmda-modulatoren oder partiellen nmda-agonisten
WO2021168106A1 (en) * 2020-02-18 2021-08-26 Praxis Precision Medicines, Inc. Deuterated neurosteroid
WO2022177718A1 (en) 2021-02-18 2022-08-25 Sage Therapeutics, Inc. Use of neuroactive steroid for treatment of sexual dysfunction
JP2024506942A (ja) 2021-02-18 2024-02-15 プラクシス プレシジョン メディシンズ， インコーポレイテッド Ｇａｂａ－ａポジティブアロステリック調節物質のヘミ－クエン酸塩およびその結晶形態
US20240197756A1 (en) * 2021-04-26 2024-06-20 Praxis Precision Medicines, Inc. Methods of treatment with neuroactive steroids
WO2023159035A1 (en) 2022-02-16 2023-08-24 Sage Therapeutics, Inc. Neuroactive steroids for treatment of cns-related disorders
WO2023159094A2 (en) * 2022-02-16 2023-08-24 Praxis Precision Medicines, Inc. PROCESS OF MAKING 3α-HYDROXY-3β-METHOXYMETHYL-21-(1'- IMIDAZOLYL)-5α-PREGNAN-20-ONE
WO2023164386A1 (en) 2022-02-28 2023-08-31 Sage Therapeutics, Inc. Neuroactive steroids for treatment of gastrointestinal diseases or conditions
JP2024115533A (ja) * 2023-02-14 2024-08-26 沢井製薬株式会社 コーティング顆粒、コーティング顆粒を含む製剤及びそれらの製造方法
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Also Published As

Publication number Publication date
PT2168585E (pt) 2012-03-05
RS51304B (sr) 2010-12-31
HRP20120264T1 (hr) 2012-04-30
EP2263675A3 (de) 2011-05-18
UA94909C2 (ru) 2011-06-25
ATE464054T1 (de) 2010-04-15
KR20080017091A (ko) 2008-02-25
CY1110199T1 (el) 2015-01-14
NO20076319L (no) 2007-12-07
IL211114A (en) 2014-04-30
KR20120028407A (ko) 2012-03-22
PL1888080T3 (pl) 2010-09-30
HRP20100372T1 (hr) 2010-08-31
EP1888080A1 (de) 2008-02-20
US20120276196A1 (en) 2012-11-01
DE602006013622D1 (de) 2010-05-27
IL187813A0 (en) 2008-08-07
SI2168585T1 (sl) 2012-04-30
PT1888080E (pt) 2010-07-06
EP2263675A2 (de) 2010-12-22
JP2008542419A (ja) 2008-11-27
IL216194A0 (en) 2012-01-31
JP2012229261A (ja) 2012-11-22
CY1112499T1 (el) 2015-12-09
BRPI0612921A2 (pt) 2010-12-07
PL2168585T3 (pl) 2012-05-31
CA2611430C (en) 2013-09-10
EP2168585A1 (de) 2010-03-31
ES2380060T3 (es) 2012-05-08
RS52199B (sr) 2012-10-31
ZA200709188B (en) 2008-08-27
AU2006256851B2 (en) 2009-12-17
WO2006131392A1 (en) 2006-12-14
WO2006131392A8 (en) 2007-02-15
EA200800007A1 (ru) 2008-04-28
HK1118202A1 (en) 2009-02-06
EP1888080B1 (de) 2010-04-14
IL187813A (en) 2011-12-29
CA2611430A1 (en) 2006-12-14
KR20100095661A (ko) 2010-08-31
NZ562979A (en) 2010-11-26
DK1888080T3 (da) 2010-07-19
AU2006256851A1 (en) 2006-12-14
EP2168585B1 (de) 2011-12-28
DK2168585T3 (da) 2012-02-27
HK1140947A1 (en) 2010-10-29
ES2344313T3 (es) 2010-08-24
CN101193640A (zh) 2008-06-04
SI1888080T1 (sl) 2010-08-31
AU2006256851C1 (en) 2010-07-15
IL216194A (en) 2013-09-30
EA013744B1 (ru) 2010-06-30
US20090131383A1 (en) 2009-05-21

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