BR0010060A - Esteróides 3<244>-hidroxi-3<225>-metoximetil-21-heterocìclo substituìdos com atividade anestésica - Google Patents

Esteróides 3<244>-hidroxi-3<225>-metoximetil-21-heterocìclo substituìdos com atividade anestésica

Info

Publication number
BR0010060A
BR0010060A BR0010060-9A BR0010060A BR0010060A BR 0010060 A BR0010060 A BR 0010060A BR 0010060 A BR0010060 A BR 0010060A BR 0010060 A BR0010060 A BR 0010060A
Authority
BR
Brazil
Prior art keywords
hydroxy
steroids
methoxymethyl
anesthetic activity
heterocycle replaced
Prior art date
Application number
BR0010060-9A
Other languages
English (en)
Inventor
Derk J Hogenkamp
Original Assignee
Purdue Pharma Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Purdue Pharma Ltd filed Critical Purdue Pharma Ltd
Publication of BR0010060A publication Critical patent/BR0010060A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Anesthesiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

"ESTERóIDES 3<244>-HIDROXI-3<225>-METOXIMETIL-21-HETEROCìCLO SUBSTITUìDOS COM ATIVIDADE ANESTéSICA". Essa invenção se refere a compostos possuindo a Fórmula (I) ou um sal farmaceuticamente aceitável, pró-droga ou solvato deles provenientes, onde R~ 1~ é H ou metila; R~ 2~ é 5<244>- ou 5<225>-H; R~ 3~ é um grupo heteroarila N-anexado opcionalmente substituído ou um grupo -X-R~ 4~; R~ 4~ é um grupo heteroarila carbono-anexado opcionalmente substituído; e X é O, S, ou N. A invenção também está direcionada ao uso de esteróides 3<244>-hidroxi-3<225>-metoximetil-substituídos como sedativos/hipnóticos e para induzir anestesia.
BR0010060-9A 1999-04-29 2000-04-28 Esteróides 3<244>-hidroxi-3<225>-metoximetil-21-heterocìclo substituìdos com atividade anestésica BR0010060A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13157899P 1999-04-29 1999-04-29
PCT/US2000/011680 WO2000066614A1 (en) 1999-04-29 2000-04-28 3α-HYDROXY-3β METHOXYMETHYL-21-HETEROCYCLE SUBSTITUTED STEROIDS WITH ANESTHETIC ACTIVITY

Publications (1)

Publication Number Publication Date
BR0010060A true BR0010060A (pt) 2002-01-15

Family

ID=22450073

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0010060-9A BR0010060A (pt) 1999-04-29 2000-04-28 Esteróides 3<244>-hidroxi-3<225>-metoximetil-21-heterocìclo substituìdos com atividade anestésica

Country Status (21)

Country Link
US (2) US20040034002A1 (pt)
EP (1) EP1177206A1 (pt)
JP (1) JP2002543218A (pt)
KR (1) KR20020013530A (pt)
CN (1) CN1187367C (pt)
AU (1) AU780989B2 (pt)
BR (1) BR0010060A (pt)
CA (1) CA2372342A1 (pt)
CZ (1) CZ20013867A3 (pt)
HK (1) HK1047594A1 (pt)
HU (1) HUP0201818A3 (pt)
IL (1) IL146230A0 (pt)
MX (1) MXPA01010915A (pt)
NO (1) NO321536B1 (pt)
NZ (1) NZ515779A (pt)
PL (1) PL351438A1 (pt)
RU (1) RU2243232C2 (pt)
UA (1) UA73736C2 (pt)
WO (1) WO2000066614A1 (pt)
YU (1) YU77701A (pt)
ZA (1) ZA200109847B (pt)

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US20060074059A1 (en) * 2004-08-26 2006-04-06 Goliber Philip A Isomorphic crystalline habits of 3alpha-hydroxy-21-(1'-imidazolyl)-3beta-methoxymethyl-5alpha-pregnane-20-one
PL2168585T3 (pl) * 2005-06-09 2012-05-31 Euro Celtique Sa Kompozycje farmaceutyczne steroidów neuroaktywnych i ich zastosowania
DE102008058436B4 (de) * 2008-11-21 2019-03-07 Osram Opto Semiconductors Gmbh Kantenemittierender Halbleiterlaserchip
EP3572417A3 (en) 2011-10-14 2020-03-25 Sage Therapeutics, Inc. 3,3 disubstituted 19-nor pregnane compounds, compositions, and uses thereof
WO2014169831A1 (en) 2013-04-17 2014-10-23 Sage Therapeutics, Inc. 19-nor c3,3-disubstituted c21-c-bound heteroaryl steroids and methods of use thereof
WO2014169836A1 (en) 2013-04-17 2014-10-23 Sage Therapeutics, Inc. 19-nor neuroactive steroids and methods of use thereof
KR102239541B1 (ko) 2013-04-17 2021-04-14 세이지 테라퓨틱스, 인크. 19-노르 c3,3-이치환된 c21-n-피라졸릴 스테로이드 및 그의 사용 방법
RU2700264C2 (ru) 2013-04-17 2019-09-16 Сейдж Терапьютикс, Инк. 19-нор нейроактивные стероиды и способы их применения
EP3868382A1 (en) 2013-07-19 2021-08-25 Sage Therapeutics, Inc. Neuroactive steroids, compositions, and uses thereof
LT3488852T (lt) * 2013-08-23 2021-02-25 Sage Therapeutics, Inc. Neuroaktyvūs steroidai, kompozicijos, ir jų naudojimas
ES2927007T3 (es) * 2014-05-29 2022-10-31 Sage Therapeutics Inc Esteroides neuroactivos, composiciones y usos de los mismos
US10246482B2 (en) 2014-06-18 2019-04-02 Sage Therapeutics, Inc. Neuroactive steroids, compositions, and uses thereof
BR112017007902B1 (pt) * 2014-10-16 2023-12-05 Sage Therapeutics, Inc Composto e seu sal, composição farmacêutica e uso do referido composto e seu sal na fabricação de um medicamento para o tratamento de distúrbios do sistema nervoso central
LT3206493T (lt) 2014-10-16 2020-08-25 Sage Therapeutics, Inc. Kompozicijos ir būdai, skirti cns sutrikimams gydyti
SI3224269T1 (sl) 2014-11-27 2020-10-30 Sage Therapeutics, Inc. Sestavki in metode za zdravljenje CNS motenj
ES2857082T3 (es) 2015-01-26 2021-09-28 Sage Therapeutics Inc Composiciones y métodos para el tratamiento de trastornos del SNC
JP6875996B2 (ja) 2015-02-20 2021-05-26 セージ セラピューティクス， インコーポレイテッド 神経刺激性ステロイド、組成物、およびその使用
MA45599A (fr) 2016-07-11 2019-05-15 Sage Therapeutics Inc Stéroïdes neuroactifs substitués en c17, c20 et c21 et leurs procédés d'utilisation
DK3481844T3 (da) 2016-07-11 2024-07-22 Sage Therapeutics Inc C7, C12 og C16 substituerede neuroaktive steroider og disses fremgangsmåder til anvendelse
US10562930B1 (en) 2018-08-31 2020-02-18 Praxis Precision Medicines, Inc. Salts and crystal forms of GABAA positive allosteric modulator
JP2022513933A (ja) * 2018-12-17 2022-02-09 イントラ－セルラー・セラピーズ・インコーポレイテッド 有機化合物
WO2020243488A1 (en) 2019-05-31 2020-12-03 Sage Therapeutics, Inc. Neuroactive steroids and compositions thereof
CN115551514A (zh) 2020-03-25 2022-12-30 萨奇治疗股份有限公司 用于治疗呼吸系统病症的药物的用途
WO2022040545A1 (en) * 2020-08-20 2022-02-24 Intra-Cellular Therapies, Inc. Organic compounds
WO2022177718A1 (en) 2021-02-18 2022-08-25 Sage Therapeutics, Inc. Use of neuroactive steroid for treatment of sexual dysfunction
WO2023159094A2 (en) * 2022-02-16 2023-08-24 Praxis Precision Medicines, Inc. PROCESS OF MAKING 3α-HYDROXY-3β-METHOXYMETHYL-21-(1'- IMIDAZOLYL)-5α-PREGNAN-20-ONE
WO2023159035A1 (en) 2022-02-16 2023-08-24 Sage Therapeutics, Inc. Neuroactive steroids for treatment of cns-related disorders
WO2023164386A1 (en) 2022-02-28 2023-08-31 Sage Therapeutics, Inc. Neuroactive steroids for treatment of gastrointestinal diseases or conditions

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Also Published As

Publication number Publication date
NO321536B1 (no) 2006-05-22
US20040034002A1 (en) 2004-02-19
CN1187367C (zh) 2005-02-02
NO20015262L (no) 2001-12-19
EP1177206A1 (en) 2002-02-06
MXPA01010915A (es) 2002-11-07
AU780989B2 (en) 2005-04-28
WO2000066614A1 (en) 2000-11-09
CN1360591A (zh) 2002-07-24
PL351438A1 (en) 2003-04-22
AU4810400A (en) 2000-11-17
HK1047594A1 (en) 2003-02-28
NO20015262D0 (no) 2001-10-26
JP2002543218A (ja) 2002-12-17
KR20020013530A (ko) 2002-02-20
YU77701A (sh) 2005-07-19
CA2372342A1 (en) 2000-11-09
IL146230A0 (en) 2002-07-25
HUP0201818A2 (en) 2002-10-28
ZA200109847B (en) 2003-02-26
WO2000066614A8 (en) 2001-03-15
UA73736C2 (en) 2005-09-15
US20050171074A1 (en) 2005-08-04
CZ20013867A3 (cs) 2002-07-17
HUP0201818A3 (en) 2004-04-28
NZ515779A (en) 2003-11-28
RU2243232C2 (ru) 2004-12-27

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Legal Events

Date Code Title Description
B25A Requested transfer of rights approved

Owner name: EURO-CELTIQUE S.A (LU)

Free format text: TRANSFERIDO DE: PURDUE PHARMA LTD.

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE 8A. E 9A. ANUIDADES

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 NA RPI2003 DE 26/05/2009.