YU77701A - 3-α-HIDROKSI-3Гџ-METOKSIMETIL-21-HETEROCIKLIČNO SUPSTITUISANI STEROIDI SA ANESTETIČKIM DEJSTVOM - Google Patents

3-α-HIDROKSI-3Гџ-METOKSIMETIL-21-HETEROCIKLIČNO SUPSTITUISANI STEROIDI SA ANESTETIČKIM DEJSTVOM

Info

Publication number
YU77701A
YU77701A YU77701A YUP77701A YU77701A YU 77701 A YU77701 A YU 77701A YU 77701 A YU77701 A YU 77701A YU P77701 A YUP77701 A YU P77701A YU 77701 A YU77701 A YU 77701A
Authority
YU
Yugoslavia
Prior art keywords
methoxymethyl
hydroxy
heterocycle substituted
substituted steroids
anesthetic activity
Prior art date
Application number
YU77701A
Other languages
English (en)
Inventor
Derk Hogenkamp
Original Assignee
Euro-Celtique S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Euro-Celtique S.A. filed Critical Euro-Celtique S.A.
Publication of YU77701A publication Critical patent/YU77701A/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Anesthesiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

Ovaj pronalazak se odnosi na jedinjenja koja imaju formulu (I) ili njegove farmaceutski prihvatljive soli,prolekove ili solvate, gde R1 je H ili metil; R2 je 5α- ili 5Гџ-H; R3 je opciono supstituisana heteroaril grupa vezana preko N ili grupa -X-R4; R4 je opciono supstituisana heteroaril grupa vezana preko ugljenika; i X je O, S ili N. Pronalazak se takodje odnosi na primenu 3α-hidroksi-3•-metoksimetil supstituisanih stereoida u proizvodnji sedativa/hipnotika i sredstava za izazivanje anestezije.[This invention relates to compounds having Formula (I) or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein; R1 is H or methyl; R2 is 5α- or 5Гџ- H; R3 is an optionally substituted i(N)-attached heteroaryl group or a group -X-R4; R4 is an optionally substituted carbon-attached heteroaryl group; and X is O, S or N. The invention also is directed to the use of 3α- hydroxy-3•- methoxymethyl-substituted steroids as sedative/hypnotics and for inducing anesthesia.
YU77701A 1999-04-29 2000-04-28 3-α-HIDROKSI-3Гџ-METOKSIMETIL-21-HETEROCIKLIČNO SUPSTITUISANI STEROIDI SA ANESTETIČKIM DEJSTVOM YU77701A (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US13157899P 1999-04-29 1999-04-29

Publications (1)

Publication Number Publication Date
YU77701A true YU77701A (sh) 2005-07-19

Family

ID=22450073

Family Applications (1)

Application Number Title Priority Date Filing Date
YU77701A YU77701A (sh) 1999-04-29 2000-04-28 3-α-HIDROKSI-3Гџ-METOKSIMETIL-21-HETEROCIKLIČNO SUPSTITUISANI STEROIDI SA ANESTETIČKIM DEJSTVOM

Country Status (21)

Country Link
US (2) US20040034002A1 (sh)
EP (1) EP1177206A1 (sh)
JP (1) JP2002543218A (sh)
KR (1) KR20020013530A (sh)
CN (1) CN1187367C (sh)
AU (1) AU780989B2 (sh)
BR (1) BR0010060A (sh)
CA (1) CA2372342A1 (sh)
CZ (1) CZ20013867A3 (sh)
HK (1) HK1047594A1 (sh)
HU (1) HUP0201818A3 (sh)
IL (1) IL146230A0 (sh)
MX (1) MXPA01010915A (sh)
NO (1) NO321536B1 (sh)
NZ (1) NZ515779A (sh)
PL (1) PL351438A1 (sh)
RU (1) RU2243232C2 (sh)
UA (1) UA73736C2 (sh)
WO (1) WO2000066614A1 (sh)
YU (1) YU77701A (sh)
ZA (1) ZA200109847B (sh)

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US20090118248A1 (en) * 2004-04-23 2009-05-07 Euro-Celtique S.A. 3-Alpha-hydroxy 21-n-heteroaryl-pregnane derivatives for modulation of brain excitability and a process for the production thereof
US20060074059A1 (en) * 2004-08-26 2006-04-06 Goliber Philip A Isomorphic crystalline habits of 3alpha-hydroxy-21-(1'-imidazolyl)-3beta-methoxymethyl-5alpha-pregnane-20-one
EP2263675A3 (en) * 2005-06-09 2011-05-18 Euro-Celtique S.A. Pharmaceutical compositions of a neuroactive steroid and uses thereof
DE102008058436B4 (de) 2008-11-21 2019-03-07 Osram Opto Semiconductors Gmbh Kantenemittierender Halbleiterlaserchip
CN113234114A (zh) 2011-10-14 2021-08-10 萨奇治疗股份有限公司 3,3-二取代的19-去甲孕甾烷化合物、组合物、及其用途
WO2014169836A1 (en) 2013-04-17 2014-10-23 Sage Therapeutics, Inc. 19-nor neuroactive steroids and methods of use thereof
CN112110976B (zh) 2013-04-17 2023-08-29 萨奇治疗股份有限公司 刺激神经活性的19-去甲类固醇及其使用方法
SI2986623T1 (sl) 2013-04-17 2019-03-29 Sage Therapeutics, Inc. 19-NOR C3,3-disubstituirani C21-N-pirazolil steroidi in metode njhove uporabe
WO2014169831A1 (en) 2013-04-17 2014-10-23 Sage Therapeutics, Inc. 19-nor c3,3-disubstituted c21-c-bound heteroaryl steroids and methods of use thereof
DK3021852T3 (da) 2013-07-19 2021-03-15 Sage Therapeutics Inc Neuroaktive steroider, sammensætninger og anvendelser deraf
WO2015027227A1 (en) 2013-08-23 2015-02-26 Sage Therapeutics, Inc. Neuroactive steroids, compositions, and uses thereof
SG10201803812TA (en) * 2014-05-29 2018-06-28 Sage Therapeutics Inc Neuroactive steroids, compositions, and uses thereof
US10246482B2 (en) 2014-06-18 2019-04-02 Sage Therapeutics, Inc. Neuroactive steroids, compositions, and uses thereof
WO2016061537A1 (en) 2014-10-16 2016-04-21 Sage Therapeutics, Inc. Compositions and methods for treating cns disorders
SG10202009859YA (en) 2014-10-16 2020-11-27 Sage Therapeutics Inc Compositions and methods for treating cns disorders
WO2016082789A1 (en) 2014-11-27 2016-06-02 Sage Therapeutics, Inc. Compositions and methods for treating cns disorders
EP3250210B1 (en) 2015-01-26 2020-12-02 Sage Therapeutics, Inc. Compositions and methods for treating cns disorders
EP4155314A1 (en) 2015-02-20 2023-03-29 Sage Therapeutics, Inc. Neuroactive steroids, compositions, and uses thereof
IL264129B2 (en) 2016-07-11 2024-05-01 Sage Therapeutics Inc C20, C17 and C21 converted neuroactive steroids and methods of using them
EP3481844B1 (en) 2016-07-11 2024-04-17 Sage Therapeutics, Inc. C7, c12, and c16 substituted neuroactive steroids and their methods of use
US10562930B1 (en) * 2018-08-31 2020-02-18 Praxis Precision Medicines, Inc. Salts and crystal forms of GABAA positive allosteric modulator
JP2022513933A (ja) * 2018-12-17 2022-02-09 イントラ－セルラー・セラピーズ・インコーポレイテッド 有機化合物
CR20210629A (es) 2019-05-31 2022-03-22 Sage Therapeutics Inc Esteroides neuroactivos y composiciones de estos
MX2022011804A (es) 2020-03-25 2023-03-09 Sage Therapeutics Inc Uso de agentes para el tratamiento de condiciones respiratorias.
US20230416300A1 (en) * 2020-08-20 2023-12-28 Intra-Cellular Therapies, Inc. Organic compounds
US20240148756A1 (en) 2021-02-18 2024-05-09 Sage Therapeutics, Inc. Use of neuroactive steroid for treatment of sexual dysfunction
WO2023159094A2 (en) * 2022-02-16 2023-08-24 Praxis Precision Medicines, Inc. PROCESS OF MAKING 3α-HYDROXY-3β-METHOXYMETHYL-21-(1'- IMIDAZOLYL)-5α-PREGNAN-20-ONE
WO2023159035A1 (en) 2022-02-16 2023-08-24 Sage Therapeutics, Inc. Neuroactive steroids for treatment of cns-related disorders
WO2023164386A1 (en) 2022-02-28 2023-08-31 Sage Therapeutics, Inc. Neuroactive steroids for treatment of gastrointestinal diseases or conditions

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US5208227A (en) * 1987-08-25 1993-05-04 University Of Southern California Method, compositions, and compounds for modulating brain excitability
US5120723A (en) * 1987-08-25 1992-06-09 University Of Southern California Method, compositions, and compounds for modulating brain excitability
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Also Published As

Publication number Publication date
JP2002543218A (ja) 2002-12-17
AU780989B2 (en) 2005-04-28
CN1360591A (zh) 2002-07-24
CZ20013867A3 (cs) 2002-07-17
PL351438A1 (en) 2003-04-22
US20040034002A1 (en) 2004-02-19
MXPA01010915A (es) 2002-11-07
CA2372342A1 (en) 2000-11-09
NO20015262L (no) 2001-12-19
AU4810400A (en) 2000-11-17
EP1177206A1 (en) 2002-02-06
NO321536B1 (no) 2006-05-22
WO2000066614A8 (en) 2001-03-15
HUP0201818A3 (en) 2004-04-28
NO20015262D0 (no) 2001-10-26
HUP0201818A2 (en) 2002-10-28
WO2000066614A1 (en) 2000-11-09
BR0010060A (pt) 2002-01-15
CN1187367C (zh) 2005-02-02
ZA200109847B (en) 2003-02-26
RU2243232C2 (ru) 2004-12-27
IL146230A0 (en) 2002-07-25
US20050171074A1 (en) 2005-08-04
KR20020013530A (ko) 2002-02-20
HK1047594A1 (en) 2003-02-28
UA73736C2 (en) 2005-09-15
NZ515779A (en) 2003-11-28

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