TR200001880T2 - İtrakonazolün bir oral preparasyonunun bileşiği ve yöntemi. - Google Patents
İtrakonazolün bir oral preparasyonunun bileşiği ve yöntemi.Info
- Publication number
- TR200001880T2 TR200001880T2 TR2000/01880T TR200001880T TR200001880T2 TR 200001880 T2 TR200001880 T2 TR 200001880T2 TR 2000/01880 T TR2000/01880 T TR 2000/01880T TR 200001880 T TR200001880 T TR 200001880T TR 200001880 T2 TR200001880 T2 TR 200001880T2
- Authority
- TR
- Turkey
- Prior art keywords
- preparation
- itraconazole
- oral
- compound
- oral preparation
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
Abstract
Mevcut bulus, mantar karsiti mükemmel bir azol ilaci olan agizdan bir itrakonazol preparasyonuna yönelik bir metot ve kompozisyonla ilgilidir. Daha özel olarak bu , gelismis biyo saglanabilirlige sahip agizdan bir itrakonazol preperasyonu ile ilgilidir; bu preperasyon, asagidaki asamalar ile hazirlanir: i) itrakonazol ve hidrofilik çözücü ile çözündürülmesi, ii) adi geçen karisimin spreyle kurutulmasi, ve iii) agizdan preparasyon için kati yayilimlar hazirlanmasi. Bu bulus dahilinde hazirlanan kati yayilimlar; tabletler, granüler ve diger agizdan dozaj formlarinin hazirlanmasinda faydali olabilir.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR19970081947 | 1997-12-31 | ||
KR1019980027730A KR100288890B1 (ko) | 1997-12-31 | 1998-07-10 | 이트라코나졸 경구용 제제 및 그의 제조방법 |
Publications (1)
Publication Number | Publication Date |
---|---|
TR200001880T2 true TR200001880T2 (tr) | 2000-11-21 |
Family
ID=26633347
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TR2000/01880T TR200001880T2 (tr) | 1997-12-31 | 1998-12-17 | İtrakonazolün bir oral preparasyonunun bileşiği ve yöntemi. |
Country Status (14)
Country | Link |
---|---|
US (1) | US6485743B1 (tr) |
EP (1) | EP1039909B1 (tr) |
JP (1) | JP3696087B2 (tr) |
CN (1) | CN1153570C (tr) |
AU (1) | AU1511399A (tr) |
BR (1) | BR9814729A (tr) |
CA (1) | CA2317106C (tr) |
DE (1) | DE69808670T2 (tr) |
ES (1) | ES2185238T3 (tr) |
HK (1) | HK1034906A1 (tr) |
PL (1) | PL191181B1 (tr) |
PT (1) | PT1039909E (tr) |
TR (1) | TR200001880T2 (tr) |
WO (1) | WO1999033467A1 (tr) |
Families Citing this family (36)
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KR100694667B1 (ko) * | 1999-12-08 | 2007-03-14 | 동아제약주식회사 | 생체내이용률 향상과 개인간 및 개인내 흡수 편차를감소시킨 이트라코나졸 함유 항진균성 제제 |
PT1239831E (pt) * | 1999-12-23 | 2013-01-23 | Mayne Pharma International Pty Ltd | Composições farmacêuticas melhoradas para fármacos fracamente solúveis |
FR2803748A1 (fr) * | 2000-01-14 | 2001-07-20 | Ethypharm Lab Prod Ethiques | Composition d'itraconazole et procede de preparation |
KR20010097244A (ko) * | 2000-04-21 | 2001-11-08 | 유충식 | 위산도 비의존성 고용해도를 갖는 이트라코나졸 함유약학적 조성물 및 그 제조방법 |
US8067032B2 (en) | 2000-12-22 | 2011-11-29 | Baxter International Inc. | Method for preparing submicron particles of antineoplastic agents |
ATE319432T1 (de) * | 2000-12-22 | 2006-03-15 | Baxter Int | Verfahren zur herstellung von submikropartikel- suspensionen pharmazeutischer substanzen |
US9700866B2 (en) | 2000-12-22 | 2017-07-11 | Baxter International Inc. | Surfactant systems for delivery of organic compounds |
AU2002317063A (en) * | 2001-06-12 | 2002-12-23 | Smartrix Technologies Inc | Itraconazole granulations: pharmaceutical formulations for oral administration and method of preparing same |
KR100425755B1 (ko) * | 2001-08-27 | 2004-04-03 | 주식회사 원진신약 | 이트라코나졸을 함유하는 조성물 및 그 제조방법 |
US20060003012A9 (en) | 2001-09-26 | 2006-01-05 | Sean Brynjelsen | Preparation of submicron solid particle suspensions by sonication of multiphase systems |
EP1429749A2 (en) | 2001-09-26 | 2004-06-23 | Baxter International Inc. | Preparation of submicron sized nanoparticles via dispersion and solvent or liquid phase removal |
FR2841138B1 (fr) * | 2002-06-25 | 2005-02-25 | Cll Pharma | Composition pharmaceutique solide contenant un principe actif lipophile, son procede de preparation |
EP1521571A1 (en) * | 2002-07-04 | 2005-04-13 | Janssen Pharmaceutica N.V. | Solid dispersion comprising two different polymer matrixes |
US20040086567A1 (en) * | 2002-10-30 | 2004-05-06 | Pawan Seth | Bioequivalent composition of itraconazole and a hydrophilic polymer |
DE60312636T3 (de) * | 2003-01-14 | 2014-12-24 | Acino Pharma Ag | Bioaequivalente Zusammensetzung in der Form einer festen Dispersion enthaltend Itraconazol und ein hydrophiles Polymer |
JP4342426B2 (ja) * | 2004-11-24 | 2009-10-14 | 科研製薬株式会社 | イトラコナゾール経口投与用製剤 |
ES2403006T3 (es) | 2005-08-22 | 2013-05-13 | The Johns Hopkins University | Antagonistas de la vía Hedgehog para tratar enfermedades |
GB0607105D0 (en) * | 2006-04-10 | 2006-05-17 | Leuven K U Res & Dev | Enhancing solubility and dissolution rate of poorly soluble drugs |
US8309129B2 (en) | 2007-05-03 | 2012-11-13 | Bend Research, Inc. | Nanoparticles comprising a drug, ethylcellulose, and a bile salt |
WO2008135855A2 (en) | 2007-05-03 | 2008-11-13 | Pfizer Products Inc. | Nanoparticles comprising a cholesteryl ester transfer protein inhibitor and a nonionizable polymer |
US8974827B2 (en) | 2007-06-04 | 2015-03-10 | Bend Research, Inc. | Nanoparticles comprising a non-ionizable cellulosic polymer and an amphiphilic non-ionizable block copolymer |
WO2008149230A2 (en) | 2007-06-04 | 2008-12-11 | Pfizer Products Inc. | Nanoparticles comprising drug, a non-ionizable cellulosic polymer and tocopheryl polyethylene glycol succinate |
WO2009073215A1 (en) | 2007-12-06 | 2009-06-11 | Bend Research, Inc. | Pharmaceutical compositions comprising nanoparticles and a resuspending material |
US9233078B2 (en) | 2007-12-06 | 2016-01-12 | Bend Research, Inc. | Nanoparticles comprising a non-ionizable polymer and an Amine-functionalized methacrylate copolymer |
WO2013093823A2 (en) | 2011-12-20 | 2013-06-27 | Vyome Biosciences Pvt Ltd | Topical oil composition for the treatment of fungal infections |
KR20220093389A (ko) | 2012-06-04 | 2022-07-05 | 파마싸이클릭스 엘엘씨 | 브루톤 타이로신 키나아제 저해제의 결정 형태 |
US8921374B2 (en) | 2012-06-21 | 2014-12-30 | Mayne Pharma International Pty Ltd | Itraconazole compositions and dosage forms, and methods of using the same |
WO2014167554A2 (en) * | 2013-04-12 | 2014-10-16 | Vyome Biosciences Pvt. Ltd. | Composition and formulation of antimicrobial agents, processes thereof and methods for treating microbial infections |
MX2016002502A (es) * | 2013-08-27 | 2017-02-28 | Voudouris Vasilios | Composiciones farmaceuticas de bendamustina. |
US10016500B2 (en) * | 2014-03-05 | 2018-07-10 | Professional Compounding Centers Of America | Poloxamer-based pharmaceutical compositions for treating wounds |
KR20170033358A (ko) * | 2014-08-07 | 2017-03-24 | 파마싸이클릭스 엘엘씨 | 브루톤 티로신 키나아제 저해제의 신규한 제제 |
CN104688536B (zh) * | 2015-02-03 | 2016-06-08 | 常州制药厂有限公司 | 一种伊曲康唑制剂的制备方法 |
DK3265084T3 (da) | 2015-03-03 | 2024-02-12 | Pharmacyclics Llc | Farmaceutiske formuleringer af Bruton's tyrosinkinase-hæmmer |
CN106511265A (zh) * | 2016-11-16 | 2017-03-22 | 北京万全德众医药生物技术有限公司 | 一种含有伊曲康唑的口服溶液及其制备工艺 |
WO2019043427A1 (en) | 2017-09-01 | 2019-03-07 | Jordan Sweden Medical And Sterilization Company | FAST SELF-DISPERSION DOSAGE FORMS OF DEFERASIROX |
CN109172532A (zh) * | 2018-10-24 | 2019-01-11 | 北京哈三联科技有限责任公司 | 一种伊曲康唑分散片及其制备方法和应用 |
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US4218458A (en) | 1978-06-23 | 1980-08-19 | Janssen Pharmaceutica, N.V. | Heterocyclic derivatives of (4-aryloxy-methyl-1,3-dioxolan-2-yl)methyl-1H-imidazoles and 1H-1,2,4-triazoles |
JPS57171428A (en) | 1981-04-13 | 1982-10-22 | Sankyo Co Ltd | Preparation of coated solid preparation |
DE3346123A1 (de) | 1983-12-21 | 1985-06-27 | Janssen Pharmaceutica, N.V., Beerse | Pharmazeutische praeparate von in wasser schwerloeslichen oder instabilen arzneistoffen und verfahren zu ihrer herstellung |
GB8506792D0 (en) | 1985-03-15 | 1985-04-17 | Janssen Pharmaceutica Nv | Derivatives of y-cyclodextrin |
JPS63188621A (ja) * | 1987-01-30 | 1988-08-04 | Taisho Pharmaceut Co Ltd | 矯味経口製剤 |
JPH0774151B2 (ja) * | 1987-10-12 | 1995-08-09 | 三井東圧化学株式会社 | 薬物の好ましくない官能的性質を隠蔽した散剤の製造方法 |
GB8908250D0 (en) | 1989-04-12 | 1989-05-24 | Fisons Plc | Formulations |
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ATE138561T1 (de) | 1992-02-12 | 1996-06-15 | Janssen Cilag S P A | Liposomale itraconazol formulierungen |
PH30929A (en) * | 1992-09-03 | 1997-12-23 | Janssen Pharmaceutica Nv | Beads having a core coated with an antifungal and a polymer. |
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FR2722984B1 (fr) | 1994-07-26 | 1996-10-18 | Effik Lab | Procede de preparation de formes pharmaceutiques seches et les compositions pharmaceutiques ainsi realisees |
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-
1998
- 1998-12-17 DE DE69808670T patent/DE69808670T2/de not_active Expired - Lifetime
- 1998-12-17 ES ES98959284T patent/ES2185238T3/es not_active Expired - Lifetime
- 1998-12-17 CN CNB988128144A patent/CN1153570C/zh not_active Expired - Fee Related
- 1998-12-17 CA CA002317106A patent/CA2317106C/en not_active Expired - Fee Related
- 1998-12-17 PT PT98959284T patent/PT1039909E/pt unknown
- 1998-12-17 EP EP98959284A patent/EP1039909B1/en not_active Expired - Lifetime
- 1998-12-17 BR BR9814729-3A patent/BR9814729A/pt not_active Application Discontinuation
- 1998-12-17 AU AU15113/99A patent/AU1511399A/en not_active Abandoned
- 1998-12-17 PL PL341566A patent/PL191181B1/pl not_active IP Right Cessation
- 1998-12-17 WO PCT/KR1998/000436 patent/WO1999033467A1/en active IP Right Grant
- 1998-12-17 TR TR2000/01880T patent/TR200001880T2/tr unknown
- 1998-12-17 JP JP2000526224A patent/JP3696087B2/ja not_active Expired - Fee Related
- 1998-12-17 US US09/582,536 patent/US6485743B1/en not_active Expired - Fee Related
-
2001
- 2001-08-13 HK HK01105615A patent/HK1034906A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
DE69808670T2 (de) | 2003-07-03 |
US6485743B1 (en) | 2002-11-26 |
PL341566A1 (en) | 2001-04-23 |
CN1285746A (zh) | 2001-02-28 |
CN1153570C (zh) | 2004-06-16 |
WO1999033467A1 (en) | 1999-07-08 |
JP2001527044A (ja) | 2001-12-25 |
DE69808670D1 (de) | 2002-11-14 |
BR9814729A (pt) | 2002-01-08 |
ES2185238T3 (es) | 2003-04-16 |
JP3696087B2 (ja) | 2005-09-14 |
EP1039909B1 (en) | 2002-10-09 |
AU1511399A (en) | 1999-07-19 |
CA2317106C (en) | 2004-11-23 |
PL191181B1 (pl) | 2006-03-31 |
EP1039909A1 (en) | 2000-10-04 |
CA2317106A1 (en) | 1999-07-08 |
HK1034906A1 (en) | 2001-11-09 |
PT1039909E (pt) | 2003-02-28 |
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