TR199802626A2 - Yeni farmasötikler. - Google Patents

Yeni farmasötikler.

Info

Publication number
TR199802626A2
TR199802626A2 TR1998/02626A TR9802626A TR199802626A2 TR 199802626 A2 TR199802626 A2 TR 199802626A2 TR 1998/02626 A TR1998/02626 A TR 1998/02626A TR 9802626 A TR9802626 A TR 9802626A TR 199802626 A2 TR199802626 A2 TR 199802626A2
Authority
TR
Turkey
Prior art keywords
compound
new pharmaceuticals
thiazolidin
xrpd
dione
Prior art date
Application number
TR1998/02626A
Other languages
English (en)
Other versions
TR199802626A3 (tr
Inventor
David James Blackler Paul
C Lee David
John Sasse Michael
Original Assignee
Smithkline Beecham P.L.C.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham P.L.C. filed Critical Smithkline Beecham P.L.C.
Publication of TR199802626A2 publication Critical patent/TR199802626A2/tr
Publication of TR199802626A3 publication Critical patent/TR199802626A3/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

(i) 0.2 ila %1.1 w/w arasinda su içermesi; ve (ii) 7641 ve 759cm-1'de doruklar içeren bir kizilötesi tayfi saglamasi; ve (iii) Sekil II'de gösterildigi üzere, bir X-isini toz sapmasi (XRPD) saglamasi ile karakterize edilen bir 5-[4-[2-(N-metil-N-(2-piridil)amino)etoksi]benzil] tiazolidin-2,4-dion, maleik asit; bu gibi bir bilesigin hazirlanmasi için bir proses, bu gibi bir bilesigi içeren farmasötik bir terkip ve bu gibi bir bilesigin veya terkibin tipta kullanilmasi.
TR1998/02626A 1997-12-16 1998-12-16 Yeni farmasötikler. TR199802626A3 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9726568.0A GB9726568D0 (en) 1997-12-16 1997-12-16 Novel pharmaceutical

Publications (2)

Publication Number Publication Date
TR199802626A2 true TR199802626A2 (tr) 1999-10-21
TR199802626A3 TR199802626A3 (tr) 1999-10-21

Family

ID=10823694

Family Applications (2)

Application Number Title Priority Date Filing Date
TR2000/01798T TR200001798T2 (tr) 1997-12-16 1998-12-14 5-(4-(2-(N-metil-N-(2-piridil) amino)oksi)benzil) tiyazolidin-2'nin hidratı, 4-diyon maleik asit tuzu.
TR1998/02626A TR199802626A3 (tr) 1997-12-16 1998-12-16 Yeni farmasötikler.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
TR2000/01798T TR200001798T2 (tr) 1997-12-16 1998-12-14 5-(4-(2-(N-metil-N-(2-piridil) amino)oksi)benzil) tiyazolidin-2'nin hidratı, 4-diyon maleik asit tuzu.

Country Status (37)

Country Link
US (2) US7045633B2 (tr)
EP (1) EP1045847A1 (tr)
JP (1) JP2002508372A (tr)
KR (1) KR100549143B1 (tr)
CN (3) CN101412713A (tr)
AP (1) AP1441A (tr)
AR (2) AR017213A1 (tr)
AU (1) AU2272399A (tr)
BG (1) BG64905B1 (tr)
BR (1) BR9813604A (tr)
CA (1) CA2314965A1 (tr)
CO (1) CO4990927A1 (tr)
CZ (1) CZ299970B6 (tr)
DZ (1) DZ2680A1 (tr)
EA (1) EA002355B1 (tr)
EG (2) EG21417A (tr)
GB (1) GB9726568D0 (tr)
HR (1) HRP20000405A2 (tr)
HU (1) HUP0100500A3 (tr)
ID (1) ID24744A (tr)
IL (1) IL136381A (tr)
IN (1) IN190821B (tr)
MA (1) MA26582A1 (tr)
MY (1) MY135770A (tr)
NO (1) NO317253B1 (tr)
NZ (1) NZ504704A (tr)
OA (1) OA11634A (tr)
PE (1) PE20000057A1 (tr)
PL (1) PL341147A1 (tr)
RS (1) RS50079B (tr)
SK (1) SK286197B6 (tr)
TR (2) TR200001798T2 (tr)
TW (1) TW467913B (tr)
UA (1) UA63980C2 (tr)
UY (2) UY25310A1 (tr)
WO (1) WO1999031094A1 (tr)
ZA (1) ZA9811505B (tr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9909041D0 (en) * 1999-04-20 1999-06-16 Smithkline Beecham Plc Novel pharmaceutical
EP1175418A2 (en) * 1999-04-23 2002-01-30 Smithkline Beecham Plc Thiazolidinedione derivative and its use as antidiabetic
BR0009934A (pt) * 1999-04-23 2002-06-04 Smithkline Beecham Plc Produto farmacêutico
US20040248945A1 (en) 1999-04-23 2004-12-09 Smithkline Beecham P.L.C. Thiazolidinedione derivative and its use as antidiabetic
GB0014005D0 (en) * 2000-06-08 2000-08-02 Smithkline Beecham Plc Novel pharmaceutical
GB0021784D0 (en) * 2000-09-05 2000-10-18 Smithkline Beecham Plc Novel pharmaceutical
GB0021978D0 (en) * 2000-09-07 2000-10-25 Smithkline Beecham Plc Novel pharmaceutical
GB0129876D0 (en) * 2001-12-13 2002-02-06 Smithkline Beecham Plc Novel pharmaceutical
WO2003050116A1 (en) * 2001-12-13 2003-06-19 Smithkline Beecham Plc A 5(-4-(2-(n-methyl-n-(2-pyridil)amino)ethoxy)benzyl)thiazolidine-2,4-dione (i) 10-camphorsulphonic acid salt and use against diabetes mellitus
AU2002350965A1 (en) * 2001-12-13 2003-06-23 Smithkline Beecham Plc Toluenesulfonate hydrates of a thiazolidinedione derivative
AU2002352479A1 (en) * 2001-12-20 2003-07-09 Smithkline Beecham Plc 5- (4- (2- (n-methyl-n- (2-pyridyl) amino) ethoxy) benzyl) thiazolidine-2, 4-dione malic acid salt and use against diabetes mellitus
GB0130511D0 (en) * 2001-12-20 2002-02-06 Smithkline Beecham Plc Novel pharmaceutical
GB2405403A (en) * 2003-08-29 2005-03-02 Cipla Ltd Rosiglitazone maleate of particular polymorphic forms and methods of preparing rosiglitazone free base
ITMI20041537A1 (it) * 2004-07-28 2004-10-28 Chemi Spa Nuova forma polimorfa del rosiglitazone maleato
CZ298424B6 (cs) * 2005-05-24 2007-09-26 Zentiva, A. S. Zpusob krystalizace rosiglitazonu a jeho derivátuze smesných rozpouštedel
EP2184055A1 (en) 2008-11-07 2010-05-12 LEK Pharmaceuticals d.d. Process for preparing solid dosage forms of rosiglitazone maleate

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR240698A1 (es) * 1985-01-19 1990-09-28 Takeda Chemical Industries Ltd Procedimiento para preparar compuestos de 5-(4-(2-(5-etil-2-piridil)-etoxi)benzil)-2,4-tiazolidindiona y sus sales
US4812570A (en) * 1986-07-24 1989-03-14 Takeda Chemical Industries, Ltd. Method for producing thiazolidinedione derivatives
ATE186724T1 (de) * 1987-09-04 1999-12-15 Beecham Group Plc Substituierte thiazolidindionderivate
GB8820389D0 (en) * 1988-08-26 1988-09-28 Beecham Group Plc Novel compounds
GB9124513D0 (en) 1991-11-19 1992-01-08 Smithkline Beecham Plc Novel process
WO1994005669A1 (en) 1992-08-28 1994-03-17 Merck & Co., Inc. Cationic-2-heteroarylphenyl-carbapenem antibacterial agents
GB9218830D0 (en) * 1992-09-05 1992-10-21 Smithkline Beecham Plc Novel compounds
US5741803A (en) 1992-09-05 1998-04-21 Smithkline Beecham Plc Substituted thiazolidinedionle derivatives
TW245716B (tr) * 1992-12-28 1995-04-21 Takeda Pharm Industry Co
DE4404198A1 (de) 1994-02-10 1995-08-17 Henkel Kgaa 2-Fluor-6-nitroaniline
GB9726566D0 (en) 1997-12-16 1998-02-11 Smithkline Beecham Plc Novel pharmaceutical
GB9726563D0 (en) 1997-12-16 1998-02-11 Smithkline Beecham Plc Novel pharmaceutical
US6664278B2 (en) * 1997-12-16 2003-12-16 Smithkline Beecham P.L.C. Hydrate of 5-[4-[2-(N-methyl-N-(2-pyridil)amino)ethoxy]benzyl]thiazolidine-2,4-dione maleic acid salt
US20020137940A1 (en) 1997-12-16 2002-09-26 Smithkline Beecham P.L.C. 5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2, 4-dione, maleic acid salt, hydrate as pharmaceutical
CZ432299A3 (cs) * 1998-06-02 2000-08-16 Smithkline Beecham Plc Kompozice obsahující 5-[4-[2-(N-methyl-N-(2- pyridyI)amino)ethoxy]benzyl]thiazolidin-2,4-dion
EP1175418A2 (en) 1999-04-23 2002-01-30 Smithkline Beecham Plc Thiazolidinedione derivative and its use as antidiabetic
BR0009934A (pt) 1999-04-23 2002-06-04 Smithkline Beecham Plc Produto farmacêutico
PL351684A1 (en) 1999-04-23 2003-06-02 Smithkline Beecham Plc Polymorph of 5−[4−[2− (n−methyl−n−( 2−pyridyl)amino) ethoxy]benzyl] thiazolidine−2,4−dione, maleic acid salt

Also Published As

Publication number Publication date
BG104595A (en) 2001-02-28
TR199802626A3 (tr) 1999-10-21
PE20000057A1 (es) 2000-03-09
UA63980C2 (en) 2004-02-16
WO1999031094A1 (en) 1999-06-24
TW467913B (en) 2001-12-11
CN101412713A (zh) 2009-04-22
CZ299970B6 (cs) 2009-01-07
UY25305A1 (es) 2000-12-29
ZA9811505B (en) 2000-11-06
UY25310A1 (es) 1999-07-19
HRP20000405A2 (en) 2000-12-31
RS50079B (sr) 2009-01-22
ID24744A (id) 2000-08-03
NO20003068L (no) 2000-06-15
KR20010033142A (ko) 2001-04-25
SK286197B6 (sk) 2008-05-06
MY135770A (en) 2008-06-30
AR017430A1 (es) 2001-09-05
HUP0100500A2 (hu) 2002-05-29
KR100549143B1 (ko) 2006-02-03
AR017213A1 (es) 2001-08-22
US7045633B2 (en) 2006-05-16
CN1281454A (zh) 2001-01-24
EG21417A (en) 2001-10-31
US20060189659A1 (en) 2006-08-24
OA11634A (en) 2004-11-22
IL136381A0 (en) 2001-06-14
NO20003068D0 (no) 2000-06-15
EA200000655A1 (ru) 2000-12-25
CZ20002205A3 (cs) 2000-11-15
HUP0100500A3 (en) 2002-08-28
NO317253B1 (no) 2004-09-27
GB9726568D0 (en) 1998-02-11
EA002355B1 (ru) 2002-04-25
AU2272399A (en) 1999-07-05
CO4990927A1 (es) 2000-12-26
EG23694A (en) 2007-05-15
BG64905B1 (bg) 2006-08-31
DZ2680A1 (fr) 2005-02-20
US20040097553A1 (en) 2004-05-20
NZ504704A (en) 2003-03-28
AP1441A (en) 2005-07-30
BR9813604A (pt) 2000-10-10
AP2000001830A0 (en) 2000-06-30
JP2002508372A (ja) 2002-03-19
PL341147A1 (en) 2001-03-26
IL136381A (en) 2003-09-17
YU36200A (sh) 2003-12-31
TR200001798T2 (tr) 2000-11-21
CN101412714A (zh) 2009-04-22
MA26582A1 (fr) 2004-12-20
IN190821B (tr) 2003-08-23
EP1045847A1 (en) 2000-10-25
SK9102000A3 (en) 2001-01-18
CA2314965A1 (en) 1999-06-24

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