UY25305A1 - Hidrato de la sal del ácido maleico de la 5-[4-[2-(n-metil-n-2-piridil)amino)etoxi]bencil]tiazolidin-2,4-diona - Google Patents

Hidrato de la sal del ácido maleico de la 5-[4-[2-(n-metil-n-2-piridil)amino)etoxi]bencil]tiazolidin-2,4-diona

Info

Publication number
UY25305A1
UY25305A1 UY25305A UY25305A UY25305A1 UY 25305 A1 UY25305 A1 UY 25305A1 UY 25305 A UY25305 A UY 25305A UY 25305 A UY25305 A UY 25305A UY 25305 A1 UY25305 A1 UY 25305A1
Authority
UY
Uruguay
Prior art keywords
methyl
thiazolidin
amino
maleic acid
compound
Prior art date
Application number
UY25305A
Other languages
English (en)
Inventor
Paul David James Blackier
Mr David Clee
Michael John Sasse
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Priority to UY25310A priority Critical patent/UY25310A1/es
Publication of UY25305A1 publication Critical patent/UY25305A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Obesity (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Un hidrato de la sal del ácido maleico de la 5-[4-[2-(N-metil-N-(2-piridil)amino)etoxi]bencil]tiazolidin-2,-diona, caracterizado porque: (i) comprende agua en el intervalo de 0,2 a 1,1 % p/p; y (ii) proporciona un espectro infrarrojo que contiene picos a 764 cm_1; y/o (iii) proporciona un patrón de difracción de rayos X en polvo (XRPD) sustancialmente como se presenta en la figura II; un proceso para la preparación de tal compuesto, una composición farmacéutica que contiene tal compuesto y el uso de tal compuesto o composición en medicina. Este compuesto es ulilizado para el tratamiento y/o profilaxis de la diabetes mellitus , condiciones asociadas con ella, complicaciones de la misma Las composiciones de esta invención pueden contener agentes activos como antihipertensivos y diuréticos. Ejemplo: hidrato de la sal de ácido maleico de la 5-(4-(2-(N-metil-N-(2-(N-metil-N-(2-piridil)amino)etoxi)bencil)tiazolidin-2,4-diona
UY25305A 1997-12-16 1998-12-15 Hidrato de la sal del ácido maleico de la 5-[4-[2-(n-metil-n-2-piridil)amino)etoxi]bencil]tiazolidin-2,4-diona UY25305A1 (es)

Priority Applications (1)

Application Number Priority Date Filing Date Title
UY25310A UY25310A1 (es) 1997-12-16 1998-12-15 Procedimiento para preparar un hidrato de la sal de ácido 5-[4-[2-(n-metil-n-(2-piridil)amino)etoxi]bencil]tiazolidin-2,4 diona maleico

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9726568.0A GB9726568D0 (en) 1997-12-16 1997-12-16 Novel pharmaceutical

Publications (1)

Publication Number Publication Date
UY25305A1 true UY25305A1 (es) 2000-12-29

Family

ID=10823694

Family Applications (2)

Application Number Title Priority Date Filing Date
UY25310A UY25310A1 (es) 1997-12-16 1998-12-15 Procedimiento para preparar un hidrato de la sal de ácido 5-[4-[2-(n-metil-n-(2-piridil)amino)etoxi]bencil]tiazolidin-2,4 diona maleico
UY25305A UY25305A1 (es) 1997-12-16 1998-12-15 Hidrato de la sal del ácido maleico de la 5-[4-[2-(n-metil-n-2-piridil)amino)etoxi]bencil]tiazolidin-2,4-diona

Family Applications Before (1)

Application Number Title Priority Date Filing Date
UY25310A UY25310A1 (es) 1997-12-16 1998-12-15 Procedimiento para preparar un hidrato de la sal de ácido 5-[4-[2-(n-metil-n-(2-piridil)amino)etoxi]bencil]tiazolidin-2,4 diona maleico

Country Status (37)

Country Link
US (2) US7045633B2 (es)
EP (1) EP1045847A1 (es)
JP (1) JP2002508372A (es)
KR (1) KR100549143B1 (es)
CN (3) CN101412714A (es)
AP (1) AP1441A (es)
AR (2) AR017213A1 (es)
AU (1) AU2272399A (es)
BG (1) BG64905B1 (es)
BR (1) BR9813604A (es)
CA (1) CA2314965A1 (es)
CO (1) CO4990927A1 (es)
CZ (1) CZ299970B6 (es)
DZ (1) DZ2680A1 (es)
EA (1) EA002355B1 (es)
EG (2) EG23694A (es)
GB (1) GB9726568D0 (es)
HR (1) HRP20000405A2 (es)
HU (1) HUP0100500A3 (es)
ID (1) ID24744A (es)
IL (1) IL136381A (es)
IN (1) IN190821B (es)
MA (1) MA26582A1 (es)
MY (1) MY135770A (es)
NO (1) NO317253B1 (es)
NZ (1) NZ504704A (es)
OA (1) OA11634A (es)
PE (1) PE20000057A1 (es)
PL (1) PL341147A1 (es)
RS (1) RS50079B (es)
SK (1) SK286197B6 (es)
TR (2) TR200001798T2 (es)
TW (1) TW467913B (es)
UA (1) UA63980C2 (es)
UY (2) UY25310A1 (es)
WO (1) WO1999031094A1 (es)
ZA (1) ZA9811505B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9909041D0 (en) * 1999-04-20 1999-06-16 Smithkline Beecham Plc Novel pharmaceutical
US20040248945A1 (en) 1999-04-23 2004-12-09 Smithkline Beecham P.L.C. Thiazolidinedione derivative and its use as antidiabetic
PE20010040A1 (es) * 1999-04-23 2001-03-10 Smithkline Beecham Plc Polimorfo de sal del acido maleico de 5-[4-[2-(n-metil-n-(2-piridil)amino)etoxi]bencil]-tiazolidina-2,4-diona
AR023750A1 (es) * 1999-04-23 2002-09-04 Smithkline Beecham Plc Un proceso para preparar una forma polimorfica de la sal del acido maleico derivado de la tiazolidina-2,4-diona
GB0014005D0 (en) * 2000-06-08 2000-08-02 Smithkline Beecham Plc Novel pharmaceutical
GB0021784D0 (en) * 2000-09-05 2000-10-18 Smithkline Beecham Plc Novel pharmaceutical
GB0021978D0 (en) * 2000-09-07 2000-10-25 Smithkline Beecham Plc Novel pharmaceutical
AU2002352391A1 (en) * 2001-12-13 2003-06-23 Smithkline Beecham Plc A 5(-4-(2-(n-methyl-n-(2-pyridil)amino)ethoxy)benzyl)thiazolidine-2,4-dione (i) 10-camphorsulphonic acid salt and use against diabetes mellitus
AU2002350965A1 (en) * 2001-12-13 2003-06-23 Smithkline Beecham Plc Toluenesulfonate hydrates of a thiazolidinedione derivative
GB0129876D0 (en) * 2001-12-13 2002-02-06 Smithkline Beecham Plc Novel pharmaceutical
GB0130511D0 (en) * 2001-12-20 2002-02-06 Smithkline Beecham Plc Novel pharmaceutical
WO2003053962A1 (en) * 2001-12-20 2003-07-03 Smithkline Beecham Plc 5- (4- (2- (n-methyl-n- (2-pyridyl) amino) ethoxy) benzyl) thiazolidine-2, 4-dione malic acid salt and use against diabetes mellitus
GB2405403A (en) * 2003-08-29 2005-03-02 Cipla Ltd Rosiglitazone maleate of particular polymorphic forms and methods of preparing rosiglitazone free base
ITMI20041537A1 (it) * 2004-07-28 2004-10-28 Chemi Spa Nuova forma polimorfa del rosiglitazone maleato
CZ298424B6 (cs) * 2005-05-24 2007-09-26 Zentiva, A. S. Zpusob krystalizace rosiglitazonu a jeho derivátuze smesných rozpouštedel
EP2184055A1 (en) 2008-11-07 2010-05-12 LEK Pharmaceuticals d.d. Process for preparing solid dosage forms of rosiglitazone maleate

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR240698A1 (es) * 1985-01-19 1990-09-28 Takeda Chemical Industries Ltd Procedimiento para preparar compuestos de 5-(4-(2-(5-etil-2-piridil)-etoxi)benzil)-2,4-tiazolidindiona y sus sales
US4812570A (en) * 1986-07-24 1989-03-14 Takeda Chemical Industries, Ltd. Method for producing thiazolidinedione derivatives
DE10199003I1 (de) * 1987-09-04 2003-06-12 Beecham Group Plc Substituierte Thiazolidinionderivate
GB8820389D0 (en) * 1988-08-26 1988-09-28 Beecham Group Plc Novel compounds
GB9124513D0 (en) 1991-11-19 1992-01-08 Smithkline Beecham Plc Novel process
WO1994005669A1 (en) 1992-08-28 1994-03-17 Merck & Co., Inc. Cationic-2-heteroarylphenyl-carbapenem antibacterial agents
GB9218830D0 (en) 1992-09-05 1992-10-21 Smithkline Beecham Plc Novel compounds
US5741803A (en) 1992-09-05 1998-04-21 Smithkline Beecham Plc Substituted thiazolidinedionle derivatives
TW245716B (es) * 1992-12-28 1995-04-21 Takeda Pharm Industry Co
DE4404198A1 (de) 1994-02-10 1995-08-17 Henkel Kgaa 2-Fluor-6-nitroaniline
US20020137940A1 (en) 1997-12-16 2002-09-26 Smithkline Beecham P.L.C. 5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2, 4-dione, maleic acid salt, hydrate as pharmaceutical
GB9726566D0 (en) 1997-12-16 1998-02-11 Smithkline Beecham Plc Novel pharmaceutical
US6664278B2 (en) * 1997-12-16 2003-12-16 Smithkline Beecham P.L.C. Hydrate of 5-[4-[2-(N-methyl-N-(2-pyridil)amino)ethoxy]benzyl]thiazolidine-2,4-dione maleic acid salt
GB9726563D0 (en) 1997-12-16 1998-02-11 Smithkline Beecham Plc Novel pharmaceutical
CZ432299A3 (cs) * 1998-06-02 2000-08-16 Smithkline Beecham Plc Kompozice obsahující 5-[4-[2-(N-methyl-N-(2- pyridyI)amino)ethoxy]benzyl]thiazolidin-2,4-dion
AR023750A1 (es) 1999-04-23 2002-09-04 Smithkline Beecham Plc Un proceso para preparar una forma polimorfica de la sal del acido maleico derivado de la tiazolidina-2,4-diona
HUP0200931A3 (en) 1999-04-23 2004-03-29 Smithkline Beecham Cork Ltd Ca Polymorph of 5-[4-[2-(n-methyl-n-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2,4-dione, maleic acid salt, process for preparation thereof and its pharmaceutical use
PE20010040A1 (es) 1999-04-23 2001-03-10 Smithkline Beecham Plc Polimorfo de sal del acido maleico de 5-[4-[2-(n-metil-n-(2-piridil)amino)etoxi]bencil]-tiazolidina-2,4-diona

Also Published As

Publication number Publication date
CN101412713A (zh) 2009-04-22
AP2000001830A0 (en) 2000-06-30
EA200000655A1 (ru) 2000-12-25
EG23694A (en) 2007-05-15
US20060189659A1 (en) 2006-08-24
AP1441A (en) 2005-07-30
AR017430A1 (es) 2001-09-05
MA26582A1 (fr) 2004-12-20
MY135770A (en) 2008-06-30
SK286197B6 (sk) 2008-05-06
CO4990927A1 (es) 2000-12-26
KR20010033142A (ko) 2001-04-25
OA11634A (en) 2004-11-22
ZA9811505B (en) 2000-11-06
BG64905B1 (bg) 2006-08-31
BG104595A (en) 2001-02-28
NZ504704A (en) 2003-03-28
IL136381A0 (en) 2001-06-14
CN101412714A (zh) 2009-04-22
TR199802626A2 (xx) 1999-10-21
CA2314965A1 (en) 1999-06-24
US20040097553A1 (en) 2004-05-20
JP2002508372A (ja) 2002-03-19
TW467913B (en) 2001-12-11
KR100549143B1 (ko) 2006-02-03
ID24744A (id) 2000-08-03
CZ20002205A3 (cs) 2000-11-15
BR9813604A (pt) 2000-10-10
EG21417A (en) 2001-10-31
NO20003068D0 (no) 2000-06-15
WO1999031094A1 (en) 1999-06-24
YU36200A (sh) 2003-12-31
CN1281454A (zh) 2001-01-24
US7045633B2 (en) 2006-05-16
GB9726568D0 (en) 1998-02-11
HUP0100500A3 (en) 2002-08-28
AR017213A1 (es) 2001-08-22
NO317253B1 (no) 2004-09-27
AU2272399A (en) 1999-07-05
IL136381A (en) 2003-09-17
EP1045847A1 (en) 2000-10-25
UY25310A1 (es) 1999-07-19
PL341147A1 (en) 2001-03-26
SK9102000A3 (en) 2001-01-18
TR200001798T2 (tr) 2000-11-21
HRP20000405A2 (en) 2000-12-31
HUP0100500A2 (hu) 2002-05-29
IN190821B (es) 2003-08-23
NO20003068L (no) 2000-06-15
CZ299970B6 (cs) 2009-01-07
PE20000057A1 (es) 2000-03-09
UA63980C2 (en) 2004-02-16
RS50079B (sr) 2009-01-22
EA002355B1 (ru) 2002-04-25
TR199802626A3 (tr) 1999-10-21
DZ2680A1 (fr) 2005-02-20

Similar Documents

Publication Publication Date Title
UY25305A1 (es) Hidrato de la sal del ácido maleico de la 5-[4-[2-(n-metil-n-2-piridil)amino)etoxi]bencil]tiazolidin-2,4-diona
UY25309A1 (es) Procedimiento para la preparación de un hidrato de un derivado de tiazolidin-2,4-diona
UY25304A1 (es) Forma hidratada de maleato de rosiglitazona
RU98117673A (ru) Фармкомпозиция для лечения и/или профилактики гипергликемии, соль малеиновой кислоты 5-[4-[2-(n-метил-n-(2-пиридил)амино) этокси] бензил] тиазолидин-2, 4-диона или ее изомерная или таутомерная форма для лечения диабета ii типа
AR023564A1 (es) Una forma polimorfica de sal del acido maleico derivado del tiazolidina-2,4 diona, una composicion farmaceutica y el uso del mismo para la fabricacion deun medicamento
EA200101101A1 (ru) Новый фармацевтический препарат
EA200101102A1 (ru) Новый фармацевтический препарат
ECSP982779A (es) Un hidrato de la sal de acido maleico, proceso para la preparacion, composicion farmaceutica y su uso en medicina
ECSP982781A (es) Hidrato de la sal de maleico de 5-[4- (-n -metil-n- (2-piridil) amino) etoxi) bensil) tiazolidina - 2,4 diona
AR017867A1 (es) Un hidrato de la sal del acido maleico de 5-4-2-(n-metil-n(2-piridil)amino)etoxi bencil tiazolidin-2,4-diona, un proceso para su preparacion, una composicion farmaceutica que lo comprende y el uso del mismo para la fabricacion de un medicamento.
HK1057751A1 (en) A thiazolidinedione derivative and its use as antidiabetic
AP2002002673A0 (en) Thiazolidinedione salt for the treatment of diabetes mellitus.
HK1057204A1 (en) A thiazolidinedione derivative and its use as antidiabetic
ECSP003434A (es) Nuevos compuestos
TH84544A (th) ไฮเดรทชนิดใหม่
NZ524933A (en) Sodium salts of 5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2,4-dione and pharmaceutical composition thereof
ECSP982780A (es) Nuevo producto farmaceutico proceso para su preparacion y su uso en medicina
BR0114364A (pt) Derivado de tiazolidinediona e seu uso como anti-diabético
HK1068884A1 (en) 5-(4-(2-(n-methyl-n-(2-pyridyl)amino)ethoxy)benzyleof; and its use as pharmaceutical active ingredie)thiazolidine-2,4-dione benzenesulfonate; process for its preparation; polymorphs i, ii and iii thernt
ECSP003438A (es) Nuevos compuestos
ECSP003436A (es) Nuevos compuestos
TH84544B (th) ไฮเดรทชนิดใหม่

Legal Events

Date Code Title Description
VENC Patent expired

Effective date: 20181215