RS50079B - Hidrat 5-/4-/2-(n-metil-n-(2-piridil) amino)etoksi/benzil/tiazolidin-2,4-dion soli maleinske kiseline - Google Patents

Hidrat 5-/4-/2-(n-metil-n-(2-piridil) amino)etoksi/benzil/tiazolidin-2,4-dion soli maleinske kiseline

Info

Publication number
RS50079B
RS50079B YUP-362/00A YU36200A RS50079B RS 50079 B RS50079 B RS 50079B YU 36200 A YU36200 A YU 36200A RS 50079 B RS50079 B RS 50079B
Authority
RS
Serbia
Prior art keywords
thiazolidine
hydrate
ethoxy
benzyl
amino
Prior art date
Application number
YUP-362/00A
Other languages
English (en)
Inventor
Paul David James Blackler
David C. Lee
Michael John Sasse
Original Assignee
Smithkline Beecham P.L.C.,
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham P.L.C., filed Critical Smithkline Beecham P.L.C.,
Publication of YU36200A publication Critical patent/YU36200A/sh
Publication of RS50079B publication Critical patent/RS50079B/sr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Abstract

Hidrat 5-[4-[2-(N-metil-N-(2-piridil)amino) etoksi]benzil]tiazolidin-2,4-dion soli maleinske kiseline, naznačen time, što: (i) sadrži vodu u opsegu od 0,2 do 1,1 masenih % i dalje okarakterisan najmanje jednim od: (ii) infracrveni spektar sadrži maksimume na 764 i 579 cm-1; (iii) rendgenski dijagram praha u suštini kao što je dato na slici 2. Prijava sadrži još 8 patentnih zahteva.
YUP-362/00A 1997-12-16 1998-12-14 Hidrat 5-/4-/2-(n-metil-n-(2-piridil) amino)etoksi/benzil/tiazolidin-2,4-dion soli maleinske kiseline RS50079B (sr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9726568.0A GB9726568D0 (en) 1997-12-16 1997-12-16 Novel pharmaceutical

Publications (2)

Publication Number Publication Date
YU36200A YU36200A (sh) 2003-12-31
RS50079B true RS50079B (sr) 2009-01-22

Family

ID=10823694

Family Applications (1)

Application Number Title Priority Date Filing Date
YUP-362/00A RS50079B (sr) 1997-12-16 1998-12-14 Hidrat 5-/4-/2-(n-metil-n-(2-piridil) amino)etoksi/benzil/tiazolidin-2,4-dion soli maleinske kiseline

Country Status (37)

Country Link
US (2) US7045633B2 (sr)
EP (1) EP1045847A1 (sr)
JP (1) JP2002508372A (sr)
KR (1) KR100549143B1 (sr)
CN (3) CN1281454A (sr)
AP (1) AP1441A (sr)
AR (2) AR017213A1 (sr)
AU (1) AU2272399A (sr)
BG (1) BG64905B1 (sr)
BR (1) BR9813604A (sr)
CA (1) CA2314965A1 (sr)
CO (1) CO4990927A1 (sr)
CZ (1) CZ299970B6 (sr)
DZ (1) DZ2680A1 (sr)
EA (1) EA002355B1 (sr)
EG (2) EG23694A (sr)
GB (1) GB9726568D0 (sr)
HR (1) HRP20000405A2 (sr)
HU (1) HUP0100500A3 (sr)
ID (1) ID24744A (sr)
IL (1) IL136381A (sr)
IN (1) IN190821B (sr)
MA (1) MA26582A1 (sr)
MY (1) MY135770A (sr)
NO (1) NO317253B1 (sr)
NZ (1) NZ504704A (sr)
OA (1) OA11634A (sr)
PE (1) PE20000057A1 (sr)
PL (1) PL341147A1 (sr)
RS (1) RS50079B (sr)
SK (1) SK286197B6 (sr)
TR (2) TR200001798T2 (sr)
TW (1) TW467913B (sr)
UA (1) UA63980C2 (sr)
UY (2) UY25310A1 (sr)
WO (1) WO1999031094A1 (sr)
ZA (1) ZA9811505B (sr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9909041D0 (en) * 1999-04-20 1999-06-16 Smithkline Beecham Plc Novel pharmaceutical
US20040248945A1 (en) 1999-04-23 2004-12-09 Smithkline Beecham P.L.C. Thiazolidinedione derivative and its use as antidiabetic
UA67845C2 (uk) * 1999-04-23 2004-07-15 Smithkline Beecham Plc Поліморф 5-[4-[2- (n-метил-n-(2-піридил)аміно)етокси]бензил]тіазолідин-2,4-діону солі малеїнової кислоти
EP1173434B1 (en) * 1999-04-23 2003-08-20 SmithKline Beecham plc Thiazolidinedione derivative and its use as antidiabetic
GB0014005D0 (en) * 2000-06-08 2000-08-02 Smithkline Beecham Plc Novel pharmaceutical
GB0021784D0 (en) * 2000-09-05 2000-10-18 Smithkline Beecham Plc Novel pharmaceutical
GB0021978D0 (en) * 2000-09-07 2000-10-25 Smithkline Beecham Plc Novel pharmaceutical
AU2002350965A1 (en) * 2001-12-13 2003-06-23 Smithkline Beecham Plc Toluenesulfonate hydrates of a thiazolidinedione derivative
GB0129876D0 (en) * 2001-12-13 2002-02-06 Smithkline Beecham Plc Novel pharmaceutical
AU2002352391A1 (en) * 2001-12-13 2003-06-23 Smithkline Beecham Plc A 5(-4-(2-(n-methyl-n-(2-pyridil)amino)ethoxy)benzyl)thiazolidine-2,4-dione (i) 10-camphorsulphonic acid salt and use against diabetes mellitus
WO2003053962A1 (en) * 2001-12-20 2003-07-03 Smithkline Beecham Plc 5- (4- (2- (n-methyl-n- (2-pyridyl) amino) ethoxy) benzyl) thiazolidine-2, 4-dione malic acid salt and use against diabetes mellitus
GB0130511D0 (en) * 2001-12-20 2002-02-06 Smithkline Beecham Plc Novel pharmaceutical
GB2405403A (en) * 2003-08-29 2005-03-02 Cipla Ltd Rosiglitazone maleate of particular polymorphic forms and methods of preparing rosiglitazone free base
ITMI20041537A1 (it) * 2004-07-28 2004-10-28 Chemi Spa Nuova forma polimorfa del rosiglitazone maleato
CZ298424B6 (cs) * 2005-05-24 2007-09-26 Zentiva, A. S. Zpusob krystalizace rosiglitazonu a jeho derivátuze smesných rozpouštedel
EP2184055A1 (en) 2008-11-07 2010-05-12 LEK Pharmaceuticals d.d. Process for preparing solid dosage forms of rosiglitazone maleate

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR240698A1 (es) * 1985-01-19 1990-09-28 Takeda Chemical Industries Ltd Procedimiento para preparar compuestos de 5-(4-(2-(5-etil-2-piridil)-etoxi)benzil)-2,4-tiazolidindiona y sus sales
US4812570A (en) * 1986-07-24 1989-03-14 Takeda Chemical Industries, Ltd. Method for producing thiazolidinedione derivatives
EP0842925A1 (en) 1987-09-04 1998-05-20 Beecham Group Plc Substituted thiazolidinedione derivatives
GB8820389D0 (en) * 1988-08-26 1988-09-28 Beecham Group Plc Novel compounds
GB9124513D0 (en) 1991-11-19 1992-01-08 Smithkline Beecham Plc Novel process
AU5082993A (en) 1992-08-28 1994-03-29 Merck & Co., Inc. Cationic-2-heteroarylphenyl-carbapenem antibacterial agents
GB9218830D0 (en) 1992-09-05 1992-10-21 Smithkline Beecham Plc Novel compounds
US5741803A (en) 1992-09-05 1998-04-21 Smithkline Beecham Plc Substituted thiazolidinedionle derivatives
TW245716B (sr) * 1992-12-28 1995-04-21 Takeda Pharm Industry Co
DE4404198A1 (de) 1994-02-10 1995-08-17 Henkel Kgaa 2-Fluor-6-nitroaniline
US20020137940A1 (en) 1997-12-16 2002-09-26 Smithkline Beecham P.L.C. 5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2, 4-dione, maleic acid salt, hydrate as pharmaceutical
GB9726563D0 (en) 1997-12-16 1998-02-11 Smithkline Beecham Plc Novel pharmaceutical
GB9726566D0 (en) 1997-12-16 1998-02-11 Smithkline Beecham Plc Novel pharmaceutical
US6664278B2 (en) * 1997-12-16 2003-12-16 Smithkline Beecham P.L.C. Hydrate of 5-[4-[2-(N-methyl-N-(2-pyridil)amino)ethoxy]benzyl]thiazolidine-2,4-dione maleic acid salt
CZ432299A3 (cs) * 1998-06-02 2000-08-16 Smithkline Beecham Plc Kompozice obsahující 5-[4-[2-(N-methyl-N-(2- pyridyI)amino)ethoxy]benzyl]thiazolidin-2,4-dion
EP1173434B1 (en) 1999-04-23 2003-08-20 SmithKline Beecham plc Thiazolidinedione derivative and its use as antidiabetic
PE20010044A1 (es) 1999-04-23 2001-03-10 Smithkline Beecham Plc Polimorfo de sal del acido maleico de 5-[4-[2-(n-metil-n-(2-piridil)amino)etoxi]bencil]-tiazolidina-2,4-diona
UA67845C2 (uk) 1999-04-23 2004-07-15 Smithkline Beecham Plc Поліморф 5-[4-[2- (n-метил-n-(2-піридил)аміно)етокси]бензил]тіазолідин-2,4-діону солі малеїнової кислоти

Also Published As

Publication number Publication date
WO1999031094A1 (en) 1999-06-24
YU36200A (sh) 2003-12-31
IL136381A0 (en) 2001-06-14
PE20000057A1 (es) 2000-03-09
UA63980C2 (en) 2004-02-16
AP2000001830A0 (en) 2000-06-30
HRP20000405A2 (en) 2000-12-31
OA11634A (en) 2004-11-22
PL341147A1 (en) 2001-03-26
CZ20002205A3 (cs) 2000-11-15
US20040097553A1 (en) 2004-05-20
NO20003068D0 (no) 2000-06-15
AU2272399A (en) 1999-07-05
AR017430A1 (es) 2001-09-05
SK286197B6 (sk) 2008-05-06
MA26582A1 (fr) 2004-12-20
JP2002508372A (ja) 2002-03-19
CO4990927A1 (es) 2000-12-26
HUP0100500A3 (en) 2002-08-28
KR20010033142A (ko) 2001-04-25
UY25305A1 (es) 2000-12-29
EP1045847A1 (en) 2000-10-25
CN101412714A (zh) 2009-04-22
AR017213A1 (es) 2001-08-22
NZ504704A (en) 2003-03-28
UY25310A1 (es) 1999-07-19
US20060189659A1 (en) 2006-08-24
CN1281454A (zh) 2001-01-24
IL136381A (en) 2003-09-17
MY135770A (en) 2008-06-30
US7045633B2 (en) 2006-05-16
KR100549143B1 (ko) 2006-02-03
EA200000655A1 (ru) 2000-12-25
ID24744A (id) 2000-08-03
TR200001798T2 (tr) 2000-11-21
DZ2680A1 (fr) 2005-02-20
NO20003068L (no) 2000-06-15
GB9726568D0 (en) 1998-02-11
IN190821B (sr) 2003-08-23
BR9813604A (pt) 2000-10-10
TR199802626A3 (tr) 1999-10-21
CA2314965A1 (en) 1999-06-24
NO317253B1 (no) 2004-09-27
ZA9811505B (en) 2000-11-06
BG104595A (en) 2001-02-28
HUP0100500A2 (hu) 2002-05-29
TW467913B (en) 2001-12-11
EG23694A (en) 2007-05-15
CZ299970B6 (cs) 2009-01-07
SK9102000A3 (en) 2001-01-18
EG21417A (en) 2001-10-31
TR199802626A2 (xx) 1999-10-21
BG64905B1 (bg) 2006-08-31
EA002355B1 (ru) 2002-04-25
AP1441A (en) 2005-07-30
CN101412713A (zh) 2009-04-22

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