RS50080B - Hidrat 5-(4-(2-9n-metil-n-(2- piridil)amino)etoksi)benzil)tiazolidin-2,4-dion soli maleinske kiseline - Google Patents

Hidrat 5-(4-(2-9n-metil-n-(2- piridil)amino)etoksi)benzil)tiazolidin-2,4-dion soli maleinske kiseline

Info

Publication number
RS50080B
RS50080B YUP-364/00A YU36400A RS50080B RS 50080 B RS50080 B RS 50080B YU 36400 A YU36400 A YU 36400A RS 50080 B RS50080 B RS 50080B
Authority
RS
Serbia
Prior art keywords
thiazolidineodine
derivative
substituted
preparation
pharmaceutical use
Prior art date
Application number
YUP-364/00A
Other languages
English (en)
Inventor
Michael John Sasse
Bernadette Maria Choudary
Ian Robert Lynch
Original Assignee
Smithkline Beecham P.L.C.,
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham P.L.C., filed Critical Smithkline Beecham P.L.C.,
Publication of YU36400A publication Critical patent/YU36400A/sh
Publication of RS50080B publication Critical patent/RS50080B/sr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Hidrat 5-(4-(2-N-metil-N-(2-piridil)amino)etoksi) benzil)tiazolidin-2,4-dion soli maleinske kiseline, naznačen time, što (i) sadrži vodu u opsegu od 0,3 do 0,6 molarna ekvivalenta; i što je dalje okarakterisan bar jednim od (ii) infracrveni spektar sadrži pikove na 1757, 1331, 1290, 121 1 i 767 cm-1; (iii) Raman-ov spektar sa pikovima na 1758, 1610, 1394, 1316 i 1289 cm-1; (iv) spektar nuklearne magnetne rezonance (NMR) čvrstog stanja kako je dato u tabeli I; (v) rendgenski dijagram praha (XRPD) u suštini kao što je dato na slici 4. Prijava sadrži još 11 patentnih zahteva.
YUP-364/00A 1997-12-16 1998-12-14 Hidrat 5-(4-(2-9n-metil-n-(2- piridil)amino)etoksi)benzil)tiazolidin-2,4-dion soli maleinske kiseline RS50080B (sr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9726563.1A GB9726563D0 (en) 1997-12-16 1997-12-16 Novel pharmaceutical

Publications (2)

Publication Number Publication Date
YU36400A YU36400A (sh) 2003-12-31
RS50080B true RS50080B (sr) 2009-01-22

Family

ID=10823691

Family Applications (1)

Application Number Title Priority Date Filing Date
YUP-364/00A RS50080B (sr) 1997-12-16 1998-12-14 Hidrat 5-(4-(2-9n-metil-n-(2- piridil)amino)etoksi)benzil)tiazolidin-2,4-dion soli maleinske kiseline

Country Status (37)

Country Link
US (4) US20020133016A1 (sr)
EP (1) EP1042321A1 (sr)
JP (1) JP2002508371A (sr)
KR (1) KR100549141B1 (sr)
CN (3) CN101318956A (sr)
AP (1) AP1363A (sr)
AR (2) AR017211A1 (sr)
AU (2) AU2272299A (sr)
BG (1) BG64850B1 (sr)
BR (1) BR9813598A (sr)
CA (1) CA2314967A1 (sr)
CO (1) CO4990943A1 (sr)
CZ (1) CZ300081B6 (sr)
DZ (1) DZ2679A1 (sr)
EA (1) EA002833B1 (sr)
EG (1) EG22250A (sr)
GB (1) GB9726563D0 (sr)
HR (1) HRP20000404A2 (sr)
HU (1) HUP0102292A3 (sr)
ID (1) ID24714A (sr)
IL (2) IL136425A (sr)
MA (1) MA26581A1 (sr)
MY (1) MY128573A (sr)
NO (1) NO317255B1 (sr)
NZ (1) NZ504703A (sr)
OA (1) OA11900A (sr)
PE (1) PE20000125A1 (sr)
PL (1) PL341213A1 (sr)
RS (1) RS50080B (sr)
SA (1) SA99200200B1 (sr)
SK (1) SK286422B6 (sr)
TR (2) TR200001793T2 (sr)
TW (1) TW487709B (sr)
UA (1) UA66821C2 (sr)
UY (2) UY25309A1 (sr)
WO (1) WO1999031093A1 (sr)
ZA (1) ZA9811504B (sr)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE39384E1 (en) 1993-09-01 2006-11-07 Smithkline Beecham P.L.C. Substituted thiazolidinedione derivatives
US6664278B2 (en) 1997-12-16 2003-12-16 Smithkline Beecham P.L.C. Hydrate of 5-[4-[2-(N-methyl-N-(2-pyridil)amino)ethoxy]benzyl]thiazolidine-2,4-dione maleic acid salt
GB9726568D0 (en) * 1997-12-16 1998-02-11 Smithkline Beecham Plc Novel pharmaceutical
US20020137940A1 (en) 1997-12-16 2002-09-26 Smithkline Beecham P.L.C. 5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2, 4-dione, maleic acid salt, hydrate as pharmaceutical
GB9909041D0 (en) * 1999-04-20 1999-06-16 Smithkline Beecham Plc Novel pharmaceutical
AU765005B2 (en) * 1999-04-23 2003-09-04 Smithkline Beecham Plc Polymorph of 5-(4-(2- (N-methyl-N-( 2-pyridyl)amino) ethoxy)benzyl) thiazolidine-2,4-dione, maleic acid salt
US20040248945A1 (en) 1999-04-23 2004-12-09 Smithkline Beecham P.L.C. Thiazolidinedione derivative and its use as antidiabetic
UA67845C2 (uk) * 1999-04-23 2004-07-15 Smithkline Beecham Plc Поліморф 5-[4-[2- (n-метил-n-(2-піридил)аміно)етокси]бензил]тіазолідин-2,4-діону солі малеїнової кислоти
PL351686A1 (en) 1999-04-23 2003-06-02 Smithkline Beecham Plc Novel pharmaceutical
GB0014005D0 (en) * 2000-06-08 2000-08-02 Smithkline Beecham Plc Novel pharmaceutical
GB0021784D0 (en) * 2000-09-05 2000-10-18 Smithkline Beecham Plc Novel pharmaceutical
GB0021978D0 (en) * 2000-09-07 2000-10-25 Smithkline Beecham Plc Novel pharmaceutical
WO2003050112A1 (en) * 2001-12-13 2003-06-19 Smithkline Beecham Plc Toluenesulfonate hydrates of a thiazolidinedione derivative
GB0129876D0 (en) * 2001-12-13 2002-02-06 Smithkline Beecham Plc Novel pharmaceutical
KR100450700B1 (ko) * 2002-03-22 2004-10-01 주식회사종근당 티아졸리딘디온 유도체 화합물 및 이를 함유하는 약제학적조성물
EP1468997A3 (en) * 2003-04-18 2004-11-03 CHEMI S.p.A. Polymorphous forms of rosiglitazone maleate
GB2405403A (en) * 2003-08-29 2005-03-02 Cipla Ltd Rosiglitazone maleate of particular polymorphic forms and methods of preparing rosiglitazone free base
EP1732513A2 (en) * 2003-12-31 2006-12-20 Alpharma, Inc. Rosiglitazone formulations
US20050163842A1 (en) * 2003-12-31 2005-07-28 Garth Boehm Rosiglitazone and metformin formulations
ITMI20041537A1 (it) * 2004-07-28 2004-10-28 Chemi Spa Nuova forma polimorfa del rosiglitazone maleato
CZ298424B6 (cs) * 2005-05-24 2007-09-26 Zentiva, A. S. Zpusob krystalizace rosiglitazonu a jeho derivátuze smesných rozpouštedel
US7435741B2 (en) * 2006-05-09 2008-10-14 Teva Pharmaceutical Industries, Ltd. 2-N{5-[[4-[2-(methyl-2-pyridinylamino) ethoxy] phenyl]methyl]-2,4-thiazolidinedione} butanedioic acid, methods of preparation and compositions with rosiglitazone maleate
EP2184055A1 (en) 2008-11-07 2010-05-12 LEK Pharmaceuticals d.d. Process for preparing solid dosage forms of rosiglitazone maleate

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0842925A1 (en) 1987-09-04 1998-05-20 Beecham Group Plc Substituted thiazolidinedione derivatives
US6288095B1 (en) 1987-09-04 2001-09-11 Beecham Group P.L.C. Compounds
GB8820389D0 (en) * 1988-08-26 1988-09-28 Beecham Group Plc Novel compounds
GB9124513D0 (en) * 1991-11-19 1992-01-08 Smithkline Beecham Plc Novel process
US5741803A (en) 1992-09-05 1998-04-21 Smithkline Beecham Plc Substituted thiazolidinedionle derivatives
GB9218830D0 (en) 1992-09-05 1992-10-21 Smithkline Beecham Plc Novel compounds
CN1083715C (zh) * 1994-02-10 2002-05-01 史密丝克莱恩比彻姆有限公司 胰岛素敏化物治疗肾病的应用
DE4404198A1 (de) 1994-02-10 1995-08-17 Henkel Kgaa 2-Fluor-6-nitroaniline
US20020137940A1 (en) 1997-12-16 2002-09-26 Smithkline Beecham P.L.C. 5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2, 4-dione, maleic acid salt, hydrate as pharmaceutical
US6664278B2 (en) 1997-12-16 2003-12-16 Smithkline Beecham P.L.C. Hydrate of 5-[4-[2-(N-methyl-N-(2-pyridil)amino)ethoxy]benzyl]thiazolidine-2,4-dione maleic acid salt
WO2002026737A1 (en) 2000-09-26 2002-04-04 Dr. Reddy's Research Foundation Novel polymorphic forms of 5-[4-[2-[n-methyl-n-(2-pyridyl)amino]ethoxy]benzyl] thiazolidine-2,4-dione maleate and process for their preparation

Also Published As

Publication number Publication date
AU2753802A (en) 2002-05-16
GB9726563D0 (en) 1998-02-11
YU36400A (sh) 2003-12-31
US20050288513A1 (en) 2005-12-29
AU770818B2 (en) 2004-03-04
PE20000125A1 (es) 2000-03-03
EA002833B1 (ru) 2002-10-31
US20030139604A1 (en) 2003-07-24
AU2272299A (en) 1999-07-05
CZ300081B6 (cs) 2009-01-28
CZ20002206A3 (cs) 2000-12-13
PL341213A1 (en) 2001-03-26
AR017211A1 (es) 2001-08-22
NZ504703A (en) 2002-12-20
MA26581A1 (fr) 2004-12-20
CN101318956A (zh) 2008-12-10
BG64850B1 (bg) 2006-06-30
UY25306A1 (es) 2000-12-29
UY25309A1 (es) 1999-07-19
TR199802624A3 (tr) 1999-10-21
US7368574B2 (en) 2008-05-06
US20070037859A1 (en) 2007-02-15
ZA9811504B (en) 2000-06-15
NO20003070D0 (no) 2000-06-15
US20020133016A1 (en) 2002-09-19
HUP0102292A2 (hu) 2002-05-29
JP2002508371A (ja) 2002-03-19
SA99200200B1 (ar) 2006-11-11
TR200001793T2 (tr) 2000-10-23
WO1999031093A1 (en) 1999-06-24
EA200000656A1 (ru) 2000-12-25
ID24714A (id) 2000-08-03
HRP20000404A2 (en) 2000-12-31
DZ2679A1 (fr) 2003-03-29
IL136425A (en) 2004-08-31
CN101318957A (zh) 2008-12-10
TW487709B (en) 2002-05-21
IL160847A0 (en) 2004-08-31
OA11900A (en) 2006-04-10
KR20010033140A (ko) 2001-04-25
MY128573A (en) 2007-02-28
AR016161A1 (es) 2001-06-20
AP2000001829A0 (en) 2000-06-30
CA2314967A1 (en) 1999-06-24
CO4990943A1 (es) 2000-12-26
CN1285831A (zh) 2001-02-28
EG22250A (en) 2002-11-30
SK9182000A3 (en) 2000-12-11
IL136425A0 (en) 2001-06-14
AP1363A (en) 2005-01-21
EP1042321A1 (en) 2000-10-11
TR199802624A2 (xx) 1999-10-21
NO20003070L (no) 2000-06-15
NO317255B1 (no) 2004-09-27
BR9813598A (pt) 2000-10-10
HUP0102292A3 (en) 2003-12-29
UA66821C2 (uk) 2004-06-15
SK286422B6 (sk) 2008-09-05
BG104606A (en) 2001-02-28
KR100549141B1 (ko) 2006-02-03

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