TR200401874T2 - Tert-butil(E)- (6-[2-[4-(4-Fluorofenil)-6-izopropil-2-[metil (metilsülfonil)amino]-pirimidin-5-il]vinil (4R,6S)-2, 2-Dimetil[1,3]Dioksan-4-il)asetatın üretimi için işlem. - Google Patents
Tert-butil(E)- (6-[2-[4-(4-Fluorofenil)-6-izopropil-2-[metil (metilsülfonil)amino]-pirimidin-5-il]vinil (4R,6S)-2, 2-Dimetil[1,3]Dioksan-4-il)asetatın üretimi için işlem.Info
- Publication number
- TR200401874T2 TR200401874T2 TR2004/01874T TR200401874T TR200401874T2 TR 200401874 T2 TR200401874 T2 TR 200401874T2 TR 2004/01874 T TR2004/01874 T TR 2004/01874T TR 200401874 T TR200401874 T TR 200401874T TR 200401874 T2 TR200401874 T2 TR 200401874T2
- Authority
- TR
- Turkey
- Prior art keywords
- dioxan
- methylsulfonyl
- pyrimidin
- fluorophenyl
- isopropyl
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 238000004519 manufacturing process Methods 0.000 title abstract 3
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 title abstract 2
- 125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000004170 methylsulfonyl group Chemical group [H]C([H])([H])S(*)(=O)=O 0.000 abstract 1
- 239000008177 pharmaceutical agent Substances 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 abstract 1
- 229920002554 vinyl polymer Polymers 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6509—Six-membered rings
- C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Bu bulus, ter-butil(E)-(6-{2-[4-(4-fluorofenil)-6-izopropil-2- [metil(metilsülfonil)amino]- pirimidin-5-il]vinil}-(4R,6S)-2,2-dimetil[1,3] dioksan-4-il)asetatin imalati için bir isleme, bahsedilen islemde kullanilan yeni baslangiç malzemesine ve islemin bir farmasötik maddenin imalatinda kullanimina iliskindir.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9903472.0A GB9903472D0 (en) | 1999-02-17 | 1999-02-17 | Chemical process |
Publications (1)
Publication Number | Publication Date |
---|---|
TR200401874T2 true TR200401874T2 (tr) | 2004-10-21 |
Family
ID=10847843
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TR2004/01874T TR200401874T2 (tr) | 1999-02-17 | 2000-02-15 | Tert-butil(E)- (6-[2-[4-(4-Fluorofenil)-6-izopropil-2-[metil (metilsülfonil)amino]-pirimidin-5-il]vinil (4R,6S)-2, 2-Dimetil[1,3]Dioksan-4-il)asetatın üretimi için işlem. |
TR2001/02360T TR200102360T2 (tr) | 1999-02-17 | 2000-02-15 | Tert-butil(E)- (6[2-[4-(4-fluorofenil)-6-izopropil-2-[metil (metilsulfonil)amino]pirimidin-5-il] (4R,6S)-2, 2-dimetil[1,3]dioksan-4-il)asetatın üretim için işlem. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TR2001/02360T TR200102360T2 (tr) | 1999-02-17 | 2000-02-15 | Tert-butil(E)- (6[2-[4-(4-fluorofenil)-6-izopropil-2-[metil (metilsulfonil)amino]pirimidin-5-il] (4R,6S)-2, 2-dimetil[1,3]dioksan-4-il)asetatın üretim için işlem. |
Country Status (34)
Country | Link |
---|---|
US (2) | US6844437B1 (tr) |
EP (1) | EP1155015B1 (tr) |
JP (3) | JP2003518474A (tr) |
KR (1) | KR100648160B1 (tr) |
CN (1) | CN1145625C (tr) |
AR (1) | AR022600A1 (tr) |
AT (1) | ATE415398T1 (tr) |
AU (1) | AU760145B2 (tr) |
BR (1) | BRPI0008301B8 (tr) |
CA (1) | CA2362594C (tr) |
CL (1) | CL2003002336A1 (tr) |
CY (1) | CY1108733T1 (tr) |
CZ (1) | CZ299844B6 (tr) |
DE (1) | DE60040905D1 (tr) |
DK (1) | DK1155015T3 (tr) |
EE (2) | EE05531B1 (tr) |
ES (1) | ES2316349T3 (tr) |
GB (1) | GB9903472D0 (tr) |
HK (1) | HK1041265B (tr) |
HU (1) | HU229835B1 (tr) |
IL (2) | IL144793A0 (tr) |
IS (1) | IS2709B3 (tr) |
MX (1) | MXPA01008235A (tr) |
NO (1) | NO320739B1 (tr) |
NZ (1) | NZ513261A (tr) |
PL (1) | PL218518B1 (tr) |
PT (1) | PT1155015E (tr) |
RU (1) | RU2243969C2 (tr) |
SI (1) | SI1155015T1 (tr) |
SK (1) | SK286988B6 (tr) |
TR (2) | TR200401874T2 (tr) |
TW (1) | TWI285202B (tr) |
WO (1) | WO2000049014A1 (tr) |
ZA (1) | ZA200106370B (tr) |
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GB0218781D0 (en) * | 2002-08-13 | 2002-09-18 | Astrazeneca Ab | Chemical process |
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KR101953575B1 (ko) | 2016-10-24 | 2019-05-24 | 한양대학교 에리카산학협력단 | 스타틴계 고지혈증 치료제 합성을 위한 새로운 중간체 합성 및 이를 이용한 로수바스타틴 합성 공정 개발 |
CN108997324A (zh) * | 2018-08-21 | 2018-12-14 | 南京欧信医药技术有限公司 | 瑞舒伐他汀钙中间体的制备方法 |
CN109651259B (zh) * | 2018-12-29 | 2020-05-19 | 浙江永太科技股份有限公司 | 一种瑞舒伐他汀钙关键中间体的纯化方法 |
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DE3741509A1 (de) * | 1987-12-08 | 1989-06-22 | Hoechst Ag | Verfahren zur herstellung optisch aktiver 3-desmethylmevalonsaeurederivate sowie zwischenprodukte |
JP2648897B2 (ja) * | 1991-07-01 | 1997-09-03 | 塩野義製薬株式会社 | ピリミジン誘導体 |
FR2741620B1 (fr) * | 1995-11-28 | 1997-12-26 | Oreal | Procede de preparation de composes a groupement beta-hydroxy -delta-lactone analogues de la (+) compactine et de la (+) mevinoline |
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