DE69435044D1 - Rapamycin - Konjugate und Antikörper - Google Patents

Rapamycin - Konjugate und Antikörper

Info

Publication number
DE69435044D1
DE69435044D1 DE69435044T DE69435044T DE69435044D1 DE 69435044 D1 DE69435044 D1 DE 69435044D1 DE 69435044 T DE69435044 T DE 69435044T DE 69435044 T DE69435044 T DE 69435044T DE 69435044 D1 DE69435044 D1 DE 69435044D1
Authority
DE
Germany
Prior art keywords
antibodies
rapamycin conjugates
rapamycin
conjugates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69435044T
Other languages
English (en)
Other versions
DE69435044T2 (de
Inventor
Katherine L Molnar-Kimber
Craig E Caufield
Timothy D Ocain
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth LLC
Original Assignee
Wyeth LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth LLC filed Critical Wyeth LLC
Publication of DE69435044D1 publication Critical patent/DE69435044D1/de
Application granted granted Critical
Publication of DE69435044T2 publication Critical patent/DE69435044T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/533—Production of labelled immunochemicals with fluorescent label
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/643—Albumins, e.g. HSA, BSA, ovalbumin or a Keyhole Limpet Hemocyanin [KHL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DE69435044T 1993-04-23 1994-04-22 Rapamycin - Konjugate und Antikörper Expired - Lifetime DE69435044T2 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US5303093A 1993-04-23 1993-04-23
US22420594A 1994-04-14 1994-04-14
US224205 1994-04-14
US53030 1998-04-01

Publications (2)

Publication Number Publication Date
DE69435044D1 true DE69435044D1 (de) 2007-12-27
DE69435044T2 DE69435044T2 (de) 2008-09-18

Family

ID=26731364

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69435044T Expired - Lifetime DE69435044T2 (de) 1993-04-23 1994-04-22 Rapamycin - Konjugate und Antikörper
DE69430060T Expired - Lifetime DE69430060T2 (de) 1993-04-23 1994-04-22 Antikörper von rapamycinen mit offenem ring

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69430060T Expired - Lifetime DE69430060T2 (de) 1993-04-23 1994-04-22 Antikörper von rapamycinen mit offenem ring

Country Status (8)

Country Link
US (2) US6328970B1 (de)
EP (2) EP0710110B1 (de)
JP (3) JPH08509499A (de)
AU (1) AU686629B2 (de)
CA (1) CA2161101A1 (de)
DE (2) DE69435044T2 (de)
ES (2) ES2295093T3 (de)
WO (1) WO1994025022A1 (de)

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DK0833828T3 (da) 1995-06-09 2003-03-17 Novartis Ag Rapamycinderivater

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JP2004149542A (ja) 2004-05-27
JPH08509499A (ja) 1996-10-08
ES2295093T3 (es) 2008-04-16
DE69435044T2 (de) 2008-09-18
EP1181938A3 (de) 2002-03-20
EP0710110A1 (de) 1996-05-08
ES2176245T3 (es) 2002-12-01
AU686629B2 (en) 1998-02-12
EP1181938B1 (de) 2007-11-14
DE69430060D1 (de) 2002-04-11
EP0710110B1 (de) 2002-03-06
US20010010920A1 (en) 2001-08-02
EP0710110A4 (de) 1997-06-18
DE69430060T2 (de) 2002-11-07
US6328970B1 (en) 2001-12-11
CA2161101A1 (en) 1994-11-10
AU6772094A (en) 1994-11-21
WO1994025022A1 (en) 1994-11-10
EP1181938A2 (de) 2002-02-27
US6541612B2 (en) 2003-04-01
JP2004168782A (ja) 2004-06-17

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