IS2508B - Mótefni gegn ED-B hneppinu í fíbrónektíni, smíði þeirra og notkanir - Google Patents

Mótefni gegn ED-B hneppinu í fíbrónektíni, smíði þeirra og notkanir

Info

Publication number
IS2508B
IS2508B IS4883A IS4883A IS2508B IS 2508 B IS2508 B IS 2508B IS 4883 A IS4883 A IS 4883A IS 4883 A IS4883 A IS 4883A IS 2508 B IS2508 B IS 2508B
Authority
IS
Iceland
Prior art keywords
fibronectin
domain
antibodies
construction
specific
Prior art date
Application number
IS4883A
Other languages
English (en)
Other versions
IS4883A (is
Inventor
Alessandro Pini
Annalisa Siri
Barbara Carnemolla
Dario Neri
Enrica Balza
Giovanni Neri
Greg Winter
Laura Borsi
Luciano Zardi
Patrizia Castellani
Original Assignee
Philogen Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Philogen Srl filed Critical Philogen Srl
Publication of IS4883A publication Critical patent/IS4883A/is
Publication of IS2508B publication Critical patent/IS2508B/is

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
IS4883A 1996-05-24 1998-10-29 Mótefni gegn ED-B hneppinu í fíbrónektíni, smíði þeirra og notkanir IS2508B (is)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9610967A GB9610967D0 (en) 1996-05-24 1996-05-24 Specific binding members,materials and methods
PCT/GB1997/001412 WO1997045544A1 (en) 1996-05-24 1997-05-23 Antibodies to the ed-b domain of fibronectin, their construction and uses

Publications (2)

Publication Number Publication Date
IS4883A IS4883A (is) 1998-10-29
IS2508B true IS2508B (is) 2009-04-15

Family

ID=10794298

Family Applications (1)

Application Number Title Priority Date Filing Date
IS4883A IS2508B (is) 1996-05-24 1998-10-29 Mótefni gegn ED-B hneppinu í fíbrónektíni, smíði þeirra og notkanir

Country Status (29)

Country Link
US (3) US7273924B1 (is)
EP (1) EP0906426B1 (is)
JP (2) JP4750912B2 (is)
KR (2) KR100741452B1 (is)
CN (1) CN100447159C (is)
AT (1) ATE361364T1 (is)
AU (1) AU729081B2 (is)
BG (1) BG65138B1 (is)
BR (1) BR9709350B1 (is)
CA (1) CA2256308C (is)
CZ (1) CZ295531B6 (is)
DE (1) DE69737683T2 (is)
DK (1) DK0906426T3 (is)
EA (1) EA004329B1 (is)
ES (1) ES2286831T3 (is)
GB (1) GB9610967D0 (is)
HK (1) HK1020990A1 (is)
HU (1) HUP0200546A2 (is)
IL (2) IL127216A0 (is)
IS (1) IS2508B (is)
NO (1) NO324904B1 (is)
NZ (1) NZ333083A (is)
PL (1) PL188557B1 (is)
PT (1) PT906426E (is)
SI (1) SI0906426T1 (is)
SK (1) SK285916B6 (is)
TR (1) TR199802416T2 (is)
UA (1) UA74129C2 (is)
WO (1) WO1997045544A1 (is)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5965132A (en) 1992-03-05 1999-10-12 Board Of Regents, The University Of Texas System Methods and compositions for targeting the vasculature of solid tumors
US6749853B1 (en) 1992-03-05 2004-06-15 Board Of Regents, The University Of Texas System Combined methods and compositions for coagulation and tumor treatment
GB9610967D0 (en) 1996-05-24 1996-07-31 Cambridge Antibody Tech Specific binding members,materials and methods
US6685943B1 (en) 1997-01-21 2004-02-03 The Texas A&M University System Fibronectin binding protein compositions and methods of use
US7244826B1 (en) 1998-04-24 2007-07-17 The Regents Of The University Of California Internalizing ERB2 antibodies
TWI259837B (en) * 1998-05-11 2006-08-11 Eidgenossische Tech Hochscule Specific binding molecules for scintigraphy, conjugates containing them and therapeutic method for treatment of angiogenesis
US20030045681A1 (en) * 1998-05-11 2003-03-06 Anthony J. Zelano Specific binding molecules for scintigraphy, conjugates containing them and therapeutic method for treatment of angiogenesis
US20030176663A1 (en) * 1998-05-11 2003-09-18 Eidgenossische Technische Hochscule Specific binding molecules for scintigraphy
DE19932688B4 (de) 1999-07-13 2009-10-08 Scil Proteins Gmbh Design von Beta-Faltblatt-Proteinen des gamma-II-kristallins antikörperähnlichen
WO2001062298A2 (en) * 2000-02-24 2001-08-30 Philogen S.R.L. Compositions and methods for treatment of angiogenesis in pathological lesions
JP2003524018A (ja) * 2000-02-24 2003-08-12 アイトゲネーシシェ テクニシェ ホッホシューレ チューリッヒ フィブロネクチンのed‐bドメインに特異的な抗体、前記抗体を含む複合体、および血管形成を検出および治療するためのその使用
AU2001259837A1 (en) 2000-05-09 2001-11-20 Greenville Hospital System Therapeutic pore-forming peptides
WO2001096599A2 (en) * 2000-06-15 2001-12-20 Philogen S.R.L. Methods for quantitative determination of b-fibronectin in biological fluids and tissues
CN1246333C (zh) * 2000-09-07 2006-03-22 舍林股份公司 EDb-纤粘连蛋白结构域(II)的受体
IT1317108B1 (it) * 2000-12-06 2003-05-26 Philogen Srl Processo per la selezione di frammenti anticorporali anti-angiogenesi,frammenti anticorpali anti-angiogenesi cosi' ottenuti e loro uso.
US7456146B2 (en) * 2001-05-09 2008-11-25 Ghc Research Development Corporation Lytic peptide prodrugs
JP2005523887A (ja) 2002-01-03 2005-08-11 シエーリング アクチエンゲゼルシャフト 腫瘍の新しい診断および治療方法
PL374386A1 (en) * 2002-03-11 2005-10-17 Philogen S.P.A. Selective targeting of tumor vasculature using antibody molecules
US20040175378A1 (en) 2002-07-15 2004-09-09 Board Of Regents, The University Of Texas System Selected antibody compositions and methods for binding to aminophospholipids
WO2004083249A2 (en) 2003-03-14 2004-09-30 Wyeth Antibodies against human il-21 receptor and uses therefor
DE10324447A1 (de) 2003-05-28 2004-12-30 Scil Proteins Gmbh Generierung künstlicher Bindungsproteine auf der Grundlage von Ubiquitin
US8420087B2 (en) 2004-01-05 2013-04-16 Antisoma Research Limited Interleukin-12 targeted to oncofoetal fibronectin
US20060024757A1 (en) 2004-07-30 2006-02-02 Robert Hussa Detection of oncofetal fibronectin for selection of concepti
US7785591B2 (en) * 2004-10-14 2010-08-31 Morphosys Ag Identification and characterization of function-blocking anti-ED-B-fibronectin antibodies
EP1803814A1 (en) 2005-12-27 2007-07-04 SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. Method of improving the antibody selection capacity in phage-display library
EP1925664A1 (en) 2006-11-15 2008-05-28 Scil proteins GmbH Artificial binding proteins based on a modified alpha helical region of ubiquitin
US8253725B2 (en) * 2007-12-28 2012-08-28 St. Jude Medical, Atrial Fibrillation Division, Inc. Method and system for generating surface models of geometric structures
EP2085095B1 (en) * 2008-01-17 2012-03-07 Philogen S.p.A. Combination of an anti-EDb fibronectin antibody-IL-2 fusion protein, and a molecule binding to B cells, B cell progenitors and/or their cancerous counterpart
EP2100621A1 (en) 2008-03-10 2009-09-16 mivenion GmbH Polyether polyol dendron conjugates with effector molecules for biological targeting
EP2116555A1 (en) 2008-05-08 2009-11-11 Bayer Schering Pharma Aktiengesellschaft Use of a radioactively labelled molecule specifically binding to ED-B fibronectin in a method of treatment of Hodgkin lymphoma
IT1392027B1 (it) * 2008-12-12 2012-02-09 Castellani Anticorpo monoclonale e suo uso per la identificazione della isoforma oncofetale della fibronettina (b-fn) a scopo diagnostico o terapeutico.
AU2010332938B2 (en) 2009-12-14 2012-12-20 Navigo Proteins Gmbh A method for identifying hetero-multimeric modified ubiquitin proteins with binding capability to ligands
WO2011110490A1 (en) 2010-03-09 2011-09-15 Bayer Pharma Aktiengesellschaft Process for the production of radioactively labelled scfv antibody fragments, kits and compositions
WO2012171541A1 (en) 2011-06-15 2012-12-20 Scil Proteins Gmbh Human fusion proteins comprising interferons and hetero-dimeric modified ubiquitin proteins
WO2012172055A1 (en) 2011-06-15 2012-12-20 Scil Proteins Gmbh Dimeric binding proteins based on modified ubiquitins
US20150183846A1 (en) 2012-06-13 2015-07-02 Scil Proteins Gmbh Human fusion proteins comprising single chain tnfalpha and targeting domains
WO2014094799A1 (en) 2012-12-19 2014-06-26 Scil-Proteins-Gmbh Ubiquitin moieties as a means for prolonging serum half-life
US10611830B2 (en) * 2013-06-06 2020-04-07 Hefei Lifeon Pharmaceutical Co. Ltd. Human antibody against ED-B domain of fibronectin and uses thereof
DK3253785T3 (da) 2015-02-06 2019-07-08 Navigo Proteins Gmbh Hidtil ukendte egfr-bindingsproteiner
BR112018000477A2 (pt) 2015-07-16 2018-09-18 Navigo Proteins Gmbh proteína de ligação de imunoglobulina não natural, composição, uso da proteína de ligação de ig não natural, método de purificação de afinidade de imunoglobulinas, método de geração de uma proteína de ligação de imunoglobulina não natural, molécula de ácido nucleico, vetor, célula hospedeira ou um hospedeiro não humano, e método para a produção de uma proteína de ligação de imunoglobulina não natural
WO2017013136A1 (en) 2015-07-20 2017-01-26 Scil Proteins Gmbh Novel binding proteins based on di-ubiquitin muteins and methods for generation
WO2017084017A1 (zh) * 2015-11-16 2017-05-26 合肥立方制药股份有限公司 Ed-b蛋白在诊断组织增生中的应用
CA3022751A1 (en) 2016-05-04 2017-11-09 Navigo Proteins Gmbh Targeted compounds for the site-specific coupling of chemical moieties comprising a peptide linker
KR20230133943A (ko) 2016-08-11 2023-09-19 리플리겐 코포레이션 친화성 크로마토그래피를 위한 알칼리 안정 fc-결합 단백질
MX2019004434A (es) 2016-10-17 2019-09-26 Pfizer Anticuerpos anti-edb y conjugados anticuerpo-fármaco.
CA3065153C (en) 2017-06-07 2023-09-05 Philogen S.P.A. Vascular endothelial growth factor/anti-fibronectin antibody fusion proteins
CN111148759B (zh) * 2017-09-30 2023-09-19 合肥立方制药股份有限公司 结合至纤维连接蛋白b结构域的蛋白
US11414466B2 (en) 2017-11-07 2022-08-16 Navigo Proteins Gmbh Fusion proteins with specificity for ED-B and long serum half-life for diagnosis or treatment of cancer
WO2020070150A1 (en) 2018-10-02 2020-04-09 Philogen S.P.A Il2 immunoconjugates
EP3660039A1 (en) 2018-11-30 2020-06-03 Philogen S.p.A. Il2 immunoconjugates
EP4013783A1 (en) 2019-08-15 2022-06-22 Janssen Biotech, Inc. Materials and methods for improved single chain variable fragments
CN115087670A (zh) 2019-12-11 2022-09-20 西拉格国际有限责任公司 包含ltbr和edb结合结构域的多特异性结合分子及其用途
CN111234016B (zh) * 2020-02-23 2021-09-07 北京康普美特创新医药科技有限责任公司 一种抗补体c5分子的全人源单克隆抗体及应用
CN111171149B (zh) * 2020-02-23 2021-09-07 北京康普美特创新医药科技有限责任公司 一种抗补体c5分子的人源化单链抗体及其应用
KR102614063B1 (ko) 2020-12-24 2023-12-19 대화제약 주식회사 엑스트라도메인 b 피브로넥틴에 특이적으로 결합하는 신규한 항체
WO2023131611A1 (en) 2022-01-04 2023-07-13 Philogen S.P.A. Combination of an immunocytokine comprising il-12 and a kinase inhibitor
WO2024028258A1 (en) 2022-08-01 2024-02-08 Philochem Ag Conjugates of psma-binding moieties with cytotoxic agents
WO2024052333A1 (en) 2022-09-06 2024-03-14 Philochem Ag Multivalent fibroblast activation protein ligands for targeted delivery applications

Family Cites Families (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8308235D0 (en) 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
JPS61134325A (ja) 1984-12-04 1986-06-21 Teijin Ltd ハイブリツド抗体遺伝子の発現方法
DE3689598T2 (de) 1985-01-28 1994-06-30 Xoma Corp Arab-promoter und verfahren zur herstellung von polypeptiden einschliesslich cecropinen mittels mikrobiologischer verfahren.
GB8607679D0 (en) 1986-03-27 1986-04-30 Winter G P Recombinant dna product
US4894326A (en) 1986-04-09 1990-01-16 Fred Hutchinson Cancer Research Center Monoclonal antibody defining oncofetal structure of fibronectin
US5243029A (en) 1986-04-09 1993-09-07 Fred Hutchinson Cancer Research Center Oncofetal structure of fibronectin
CA1341235C (en) 1987-07-24 2001-05-22 Randy R. Robinson Modular assembly of antibody genes, antibodies prepared thereby and use
JPH02598A (ja) * 1987-10-09 1990-01-05 De La Rue Co Plc:The 集積回路カード
ATE140731T1 (de) 1988-01-11 1996-08-15 Xoma Corp Plasmidvektor mit pectatlyase-signalsequenz
IT1217724B (it) * 1988-05-26 1990-03-30 Ist Naz Ric Sul Cancro Anticorpo monoclonale specifico per una sequenza di fibronettina espressa in cellule trasformate ibridoma secernente tale anticorpo e impiego dell'anticorpo monoclonale per la diagnosi di tumori
US5177015A (en) 1988-08-12 1993-01-05 Fred Hutchinson Cancer Research Centre Onco-developmentally regulated α-N-acetylgalactosaminyltransferase
US5843156A (en) 1988-08-24 1998-12-01 Endoluminal Therapeutics, Inc. Local polymeric gel cellular therapy
JPH0276598A (ja) * 1988-09-14 1990-03-15 Fujita Gakuen 抗ed−b抗体
JPH04169195A (ja) * 1990-10-31 1992-06-17 Fujita Gakuen 抗ed―bモノクローナル抗体
AU3178993A (en) 1991-11-25 1993-06-28 Enzon, Inc. Multivalent antigen-binding proteins
US5629291A (en) 1992-01-31 1997-05-13 La Jolla Cancer Research Foundation Methods of modulating fibronectin extracellular matrix assembly
US6093399A (en) 1992-03-05 2000-07-25 Board Of Regents, The University Of Texas System Methods and compositions for the specific coagulation of vasculature
US6036955A (en) 1992-03-05 2000-03-14 The Scripps Research Institute Kits and methods for the specific coagulation of vasculature
US5877289A (en) 1992-03-05 1999-03-02 The Scripps Research Institute Tissue factor compositions and ligands for the specific coagulation of vasculature
US6004555A (en) 1992-03-05 1999-12-21 Board Of Regents, The University Of Texas System Methods for the specific coagulation of vasculature
US6749853B1 (en) 1992-03-05 2004-06-15 Board Of Regents, The University Of Texas System Combined methods and compositions for coagulation and tumor treatment
US5965132A (en) 1992-03-05 1999-10-12 Board Of Regents, The University Of Texas System Methods and compositions for targeting the vasculature of solid tumors
US5976535A (en) 1992-06-09 1999-11-02 Neorx Corporation Pretargeting protocols for the enhanced localization of cytotoxins to target sites and cytotoxic combinations useful therefore
CA2123699C (en) 1992-09-25 1999-12-07 Takashi Komai An adsorbent for cellular fibronectin, a method for fractional purification of fibronectin and a method of hemocatharisis
US5491130A (en) 1992-11-10 1996-02-13 The United States Of America As Represented By The Department Of Health And Human Services Peptide inhibitors of fibronectin and related collagen-binding proteins
EP0672142B1 (en) 1992-12-04 2001-02-28 Medical Research Council Multivalent and multispecific binding proteins, their manufacture and use
US6015897A (en) 1993-12-07 2000-01-18 Neorx Corporation Biotinamido-n-methylglycyl-seryl-o-succinamido-benzyl dota
US5523229A (en) 1994-03-22 1996-06-04 Trustees Of The University Of Pennsylvania Antibodies specific for oncofetal fibronectin
DE4417865A1 (de) 1994-05-20 1995-11-23 Behringwerke Ag Kombination von Tumornekrose-induzierenden Substanzen mit Substanzen, die durch Nekrosen aktiviert werden, zur selektiven Tumortherapie
ITFI940095A1 (it) 1994-05-23 1995-11-23 Molteni & C Coniugati fotodinamici aventi proprieta' biocide
US5648485A (en) 1994-10-26 1997-07-15 University Of British Columbia β, β-dihydroxy meso-substituted chlorins, isobacteriochlorins, and bacteriochlorins
WO1996023816A1 (en) 1995-02-01 1996-08-08 British Technology Group Limited Radiolabelled proteins
US6140470A (en) 1995-06-30 2000-10-31 Yale University Human monoclonal anti-tumor antibodies
US5808146A (en) 1995-11-09 1998-09-15 Emory University Amino acid analogs for tumor imaging
GB9610967D0 (en) 1996-05-24 1996-07-31 Cambridge Antibody Tech Specific binding members,materials and methods
US5913884A (en) 1996-09-19 1999-06-22 The General Hospital Corporation Inhibition of fibrosis by photodynamic therapy
GB9722131D0 (en) 1997-10-20 1997-12-17 Medical Res Council Method
US6394952B1 (en) 1998-02-03 2002-05-28 Adeza Biomedical Corporation Point of care diagnostic systems
US6267722B1 (en) 1998-02-03 2001-07-31 Adeza Biomedical Corporation Point of care diagnostic systems
TWI259837B (en) 1998-05-11 2006-08-11 Eidgenossische Tech Hochscule Specific binding molecules for scintigraphy, conjugates containing them and therapeutic method for treatment of angiogenesis
JP2003524018A (ja) 2000-02-24 2003-08-12 アイトゲネーシシェ テクニシェ ホッホシューレ チューリッヒ フィブロネクチンのed‐bドメインに特異的な抗体、前記抗体を含む複合体、および血管形成を検出および治療するためのその使用
WO2001062298A2 (en) 2000-02-24 2001-08-30 Philogen S.R.L. Compositions and methods for treatment of angiogenesis in pathological lesions
JP2005523887A (ja) 2002-01-03 2005-08-11 シエーリング アクチエンゲゼルシャフト 腫瘍の新しい診断および治療方法
JP4169195B2 (ja) * 2003-06-24 2008-10-22 株式会社河合楽器製作所 電子楽音発生装置の記録制御装置

Also Published As

Publication number Publication date
SK161298A3 (en) 1999-07-12
ATE361364T1 (de) 2007-05-15
NZ333083A (en) 2000-05-26
IL127216A0 (en) 1999-09-22
JP4750912B2 (ja) 2011-08-17
PL188557B1 (pl) 2005-02-28
TR199802416T2 (xx) 1999-02-22
CA2256308A1 (en) 1997-12-04
KR100741452B1 (ko) 2007-07-20
PT906426E (pt) 2007-07-23
CA2256308C (en) 2012-03-13
US20080274099A1 (en) 2008-11-06
DK0906426T3 (da) 2007-09-10
PL330075A1 (en) 1999-04-26
JP2009050261A (ja) 2009-03-12
CN100447159C (zh) 2008-12-31
BG65138B1 (bg) 2007-03-30
SK285916B6 (sk) 2007-11-02
JP2000511416A (ja) 2000-09-05
UA74129C2 (uk) 2005-11-15
KR20060035812A (ko) 2006-04-26
US8703143B2 (en) 2014-04-22
NO985459L (no) 1999-01-22
AU2910197A (en) 1998-01-05
US7273924B1 (en) 2007-09-25
DE69737683T2 (de) 2008-01-10
HUP0200546A2 (en) 2002-07-29
SI0906426T1 (sl) 2007-10-31
DE69737683D1 (de) 2007-06-14
BR9709350B1 (pt) 2010-12-14
EA004329B1 (ru) 2004-04-29
CN1219968A (zh) 1999-06-16
NO985459D0 (no) 1998-11-23
US9096670B2 (en) 2015-08-04
BG102950A (en) 1999-08-31
EP0906426A1 (en) 1999-04-07
CZ381598A3 (cs) 1999-03-17
ES2286831T3 (es) 2007-12-01
WO1997045544A1 (en) 1997-12-04
BR9709350A (pt) 2000-01-04
IS4883A (is) 1998-10-29
US20140134182A1 (en) 2014-05-15
EP0906426B1 (en) 2007-05-02
AU729081B2 (en) 2001-01-25
NO324904B1 (no) 2007-12-27
IL127216A (en) 2008-11-26
KR20050010081A (ko) 2005-01-26
HK1020990A1 (en) 2000-05-26
GB9610967D0 (en) 1996-07-31
CZ295531B6 (cs) 2005-08-17
EA199801043A1 (ru) 1999-04-29

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