IT1317108B1 - Processo per la selezione di frammenti anticorporali anti-angiogenesi,frammenti anticorpali anti-angiogenesi cosi' ottenuti e loro uso. - Google Patents

Processo per la selezione di frammenti anticorporali anti-angiogenesi,frammenti anticorpali anti-angiogenesi cosi' ottenuti e loro uso.

Info

Publication number
IT1317108B1
IT1317108B1 IT2000FI000247A ITFI20000247A IT1317108B1 IT 1317108 B1 IT1317108 B1 IT 1317108B1 IT 2000FI000247 A IT2000FI000247 A IT 2000FI000247A IT FI20000247 A ITFI20000247 A IT FI20000247A IT 1317108 B1 IT1317108 B1 IT 1317108B1
Authority
IT
Italy
Prior art keywords
fragments
angiogenic
selection
corpmental
corporal
Prior art date
Application number
IT2000FI000247A
Other languages
English (en)
Inventor
Leonardo Giovannoni
Original Assignee
Philogen Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to IT2000FI000247A priority Critical patent/IT1317108B1/it
Application filed by Philogen Srl filed Critical Philogen Srl
Priority to AU2002221938A priority patent/AU2002221938A1/en
Priority to JP2002548172A priority patent/JP2004527226A/ja
Priority to PCT/EP2001/014330 priority patent/WO2002046455A2/en
Priority to EP01999662A priority patent/EP1339750B1/en
Priority to CA002430713A priority patent/CA2430713A1/en
Priority to DK01999662.8T priority patent/DK1339750T3/da
Priority to AT01999662T priority patent/ATE445645T1/de
Priority to DE60140205T priority patent/DE60140205D1/de
Priority to US10/450,012 priority patent/US7723269B2/en
Publication of ITFI20000247A1 publication Critical patent/ITFI20000247A1/it
Application granted granted Critical
Publication of IT1317108B1 publication Critical patent/IT1317108B1/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/005—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
IT2000FI000247A 2000-12-06 2000-12-06 Processo per la selezione di frammenti anticorporali anti-angiogenesi,frammenti anticorpali anti-angiogenesi cosi' ottenuti e loro uso. IT1317108B1 (it)

Priority Applications (10)

Application Number Priority Date Filing Date Title
IT2000FI000247A IT1317108B1 (it) 2000-12-06 2000-12-06 Processo per la selezione di frammenti anticorporali anti-angiogenesi,frammenti anticorpali anti-angiogenesi cosi' ottenuti e loro uso.
JP2002548172A JP2004527226A (ja) 2000-12-06 2001-12-06 抗血管新生抗体断片の選択方法および該断片の使用
PCT/EP2001/014330 WO2002046455A2 (en) 2000-12-06 2001-12-06 Process for selecting anti-angiogenesis antibody fragments, anti-angiogenesis antibody fragments thus obtained and their use
EP01999662A EP1339750B1 (en) 2000-12-06 2001-12-06 Process for selecting anti-angiogenesis antibody fragments
AU2002221938A AU2002221938A1 (en) 2000-12-06 2001-12-06 Process for selecting anti-angiogenesis antibody fragments, anti-angiogenesis antibody fragments thus obtained and their use
CA002430713A CA2430713A1 (en) 2000-12-06 2001-12-06 Process for selecting anti-angiogenesis antibody fragments, anti-angiogenesis antibody fragments thus obtained and their use
DK01999662.8T DK1339750T3 (da) 2000-12-06 2001-12-06 Fremgangsmåde til udvælgelse af anti-angiogenese-antistoffragmenter
AT01999662T ATE445645T1 (de) 2000-12-06 2001-12-06 Verfahren zur selektion von anti-angiogenese antikörperfragmenten
DE60140205T DE60140205D1 (de) 2000-12-06 2001-12-06 Verfahren zur Selektion von Anti-Angiogenese Antikörperfragmenten
US10/450,012 US7723269B2 (en) 2000-12-06 2001-12-06 Process for selecting anti-angiogenesis antibody fragments, anti-angiogenesis antibody fragments thus obtained and their use

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT2000FI000247A IT1317108B1 (it) 2000-12-06 2000-12-06 Processo per la selezione di frammenti anticorporali anti-angiogenesi,frammenti anticorpali anti-angiogenesi cosi' ottenuti e loro uso.

Publications (2)

Publication Number Publication Date
ITFI20000247A1 ITFI20000247A1 (it) 2002-06-06
IT1317108B1 true IT1317108B1 (it) 2003-05-26

Family

ID=11442008

Family Applications (1)

Application Number Title Priority Date Filing Date
IT2000FI000247A IT1317108B1 (it) 2000-12-06 2000-12-06 Processo per la selezione di frammenti anticorporali anti-angiogenesi,frammenti anticorpali anti-angiogenesi cosi' ottenuti e loro uso.

Country Status (10)

Country Link
US (1) US7723269B2 (it)
EP (1) EP1339750B1 (it)
JP (1) JP2004527226A (it)
AT (1) ATE445645T1 (it)
AU (1) AU2002221938A1 (it)
CA (1) CA2430713A1 (it)
DE (1) DE60140205D1 (it)
DK (1) DK1339750T3 (it)
IT (1) IT1317108B1 (it)
WO (1) WO2002046455A2 (it)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1578513A2 (en) * 2002-02-01 2005-09-28 Cargill, Incorporated INTEGRATION OF AT LEAST TWO PROCESSES TO RE−USE ACID
WO2004003144A2 (en) * 2002-07-01 2004-01-08 Human Genome Sciences, Inc. Antibodies that specifically bind to reg iv
WO2006026020A2 (en) 2004-07-30 2006-03-09 Adeza Biomedical Corporation Oncofetal fibronectin as a marker for disease and other conditions and methods for detection of oncofetal fibronectin
US7785591B2 (en) 2004-10-14 2010-08-31 Morphosys Ag Identification and characterization of function-blocking anti-ED-B-fibronectin antibodies
CA2682851C (en) 2007-04-02 2017-01-17 Philogen S.P.A. A novel antigen associated with the neovasculature of tumour metastases
KR101781638B1 (ko) 2007-07-25 2017-09-25 필로겐 에스.피.에이. 종양 전이의 신생혈관과 관련된 피브리노겐의 ｅｄ-ａ 항원
PL3281952T3 (pl) 2007-10-30 2020-11-16 Philogen S.P.A. Antygen związany z reumatoidalnym zapaleniem stawów
US9527907B2 (en) 2009-01-07 2016-12-27 Philogen S.P.A. Antigens associated with endometriosis, psoriatic arthritis and psoriasis
US9695232B2 (en) 2012-10-03 2017-07-04 Philogen S.P.A. Anti-ED-A immunoconjugates for inflammatory bowel disease
EP3538547B1 (en) 2016-11-09 2021-07-07 Philogen S.p.A. Immunoconjugates comprising il-2, anti-fibronectin antibody and mutant tnf-alpha
CN110997718B (zh) 2017-06-07 2023-11-10 菲洛根股份公司 血管内皮生长因子/抗纤连蛋白抗体融合蛋白
EP3502139A1 (en) 2017-12-19 2019-06-26 Philogen S.p.A. Antibodies to tumour antigens
US20190351031A1 (en) 2018-05-16 2019-11-21 Halozyme, Inc. Methods of selecting subjects for combination cancer therapy with a polymer-conjugated soluble ph20
US11505782B2 (en) 2018-06-04 2022-11-22 Calidi Biotherapeutics, Inc. Cell-based vehicles for potentiation of viral therapy
EP3801584B1 (en) 2018-06-04 2023-09-27 Calidi Biotherapeutics, Inc. Cell-based vehicles for potentiation of viral therapy
WO2020021045A2 (en) 2018-07-26 2020-01-30 Ospedale Pediatrico Bambino Gesù (Opbg) Therapeutic preparations of gamma-delta t cells and natural killer cells and methods for manufacture and use
JP7329593B2 (ja) 2018-11-06 2023-08-18 カリディ・バイオセラピューティクス・インコーポレイテッド 細胞媒介性腫瘍溶解性ウイルス治療のための増強された系
WO2021226520A1 (en) 2020-05-08 2021-11-11 Kiromic BioPharma, Inc. Peptide compositions for the treatment of pathogenic infections
EP4175650A1 (en) 2020-07-06 2023-05-10 Kiromic BioPharma, Inc. Mesothelin isoform binding molecules and chimeric pd1 receptor molecules, cells containing the same and uses thereof
CA3202233A1 (en) 2020-11-18 2022-05-27 Kiromic BioPharma, Inc. Gamma-delta t cell manufacturing processes and chimeric pd1 receptor molecules

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8921880D0 (en) * 1989-09-28 1989-11-15 Medical Res Council Improvements in or relating to hybridomas
ES2136092T3 (es) * 1991-09-23 1999-11-16 Medical Res Council Procedimientos para la produccion de anticuerpos humanizados.
GB9610967D0 (en) * 1996-05-24 1996-07-31 Cambridge Antibody Tech Specific binding members,materials and methods
US6190660B1 (en) * 1996-05-31 2001-02-20 Health Research, Inc. Anti-endoglin monoclonal antibodies and their use in antiangiogenic therapy
IT1307864B1 (it) * 1999-04-20 2001-11-19 Istituto Naz Per La Ricerca Su Metodo diagnostico per il riconoscimento di neoplasie umane attraversola determinazione dell'isoforma ctn-c della tn-c, frammenti di

Also Published As

Publication number Publication date
ITFI20000247A1 (it) 2002-06-06
US7723269B2 (en) 2010-05-25
EP1339750A2 (en) 2003-09-03
DE60140205D1 (de) 2009-11-26
JP2004527226A (ja) 2004-09-09
DK1339750T3 (da) 2010-02-15
AU2002221938A1 (en) 2002-06-18
CA2430713A1 (en) 2002-06-13
WO2002046455A2 (en) 2002-06-13
ATE445645T1 (de) 2009-10-15
WO2002046455A3 (en) 2002-11-14
US20040091973A1 (en) 2004-05-13
EP1339750B1 (en) 2009-10-14

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