DK0906426T3 - Antistoffer mod ED-B-domænet af fibronektin, deres konstruktion og anvendelser - Google Patents
Antistoffer mod ED-B-domænet af fibronektin, deres konstruktion og anvendelserInfo
- Publication number
- DK0906426T3 DK0906426T3 DK97923243T DK97923243T DK0906426T3 DK 0906426 T3 DK0906426 T3 DK 0906426T3 DK 97923243 T DK97923243 T DK 97923243T DK 97923243 T DK97923243 T DK 97923243T DK 0906426 T3 DK0906426 T3 DK 0906426T3
- Authority
- DK
- Denmark
- Prior art keywords
- fibronectin
- domain
- antibodies
- construction
- specific
- Prior art date
Links
- 102000016359 Fibronectins Human genes 0.000 title abstract 3
- 108010067306 Fibronectins Proteins 0.000 title abstract 3
- 238000010276 construction Methods 0.000 title 1
- 230000027455 binding Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000009870 specific binding Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9610967A GB9610967D0 (en) | 1996-05-24 | 1996-05-24 | Specific binding members,materials and methods |
PCT/GB1997/001412 WO1997045544A1 (en) | 1996-05-24 | 1997-05-23 | Antibodies to the ed-b domain of fibronectin, their construction and uses |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0906426T3 true DK0906426T3 (da) | 2007-09-10 |
Family
ID=10794298
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK97923243T DK0906426T3 (da) | 1996-05-24 | 1997-05-23 | Antistoffer mod ED-B-domænet af fibronektin, deres konstruktion og anvendelser |
Country Status (29)
Country | Link |
---|---|
US (3) | US7273924B1 (da) |
EP (1) | EP0906426B1 (da) |
JP (2) | JP4750912B2 (da) |
KR (2) | KR100741452B1 (da) |
CN (1) | CN100447159C (da) |
AT (1) | ATE361364T1 (da) |
AU (1) | AU729081B2 (da) |
BG (1) | BG65138B1 (da) |
BR (1) | BR9709350B1 (da) |
CA (1) | CA2256308C (da) |
CZ (1) | CZ295531B6 (da) |
DE (1) | DE69737683T2 (da) |
DK (1) | DK0906426T3 (da) |
EA (1) | EA004329B1 (da) |
ES (1) | ES2286831T3 (da) |
GB (1) | GB9610967D0 (da) |
HK (1) | HK1020990A1 (da) |
HU (1) | HUP0200546A2 (da) |
IL (2) | IL127216A0 (da) |
IS (1) | IS2508B (da) |
NO (1) | NO324904B1 (da) |
NZ (1) | NZ333083A (da) |
PL (1) | PL188557B1 (da) |
PT (1) | PT906426E (da) |
SI (1) | SI0906426T1 (da) |
SK (1) | SK285916B6 (da) |
TR (1) | TR199802416T2 (da) |
UA (1) | UA74129C2 (da) |
WO (1) | WO1997045544A1 (da) |
Families Citing this family (58)
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US6749853B1 (en) | 1992-03-05 | 2004-06-15 | Board Of Regents, The University Of Texas System | Combined methods and compositions for coagulation and tumor treatment |
US5965132A (en) | 1992-03-05 | 1999-10-12 | Board Of Regents, The University Of Texas System | Methods and compositions for targeting the vasculature of solid tumors |
GB9610967D0 (en) | 1996-05-24 | 1996-07-31 | Cambridge Antibody Tech | Specific binding members,materials and methods |
US6685943B1 (en) | 1997-01-21 | 2004-02-03 | The Texas A&M University System | Fibronectin binding protein compositions and methods of use |
US7244826B1 (en) | 1998-04-24 | 2007-07-17 | The Regents Of The University Of California | Internalizing ERB2 antibodies |
US20030176663A1 (en) * | 1998-05-11 | 2003-09-18 | Eidgenossische Technische Hochscule | Specific binding molecules for scintigraphy |
TWI259837B (en) * | 1998-05-11 | 2006-08-11 | Eidgenossische Tech Hochscule | Specific binding molecules for scintigraphy, conjugates containing them and therapeutic method for treatment of angiogenesis |
US20030045681A1 (en) * | 1998-05-11 | 2003-03-06 | Anthony J. Zelano | Specific binding molecules for scintigraphy, conjugates containing them and therapeutic method for treatment of angiogenesis |
DE19932688B4 (de) | 1999-07-13 | 2009-10-08 | Scil Proteins Gmbh | Design von Beta-Faltblatt-Proteinen des gamma-II-kristallins antikörperähnlichen |
EP1259548A1 (en) * | 2000-02-24 | 2002-11-27 | Eidgenössische Technische Hochschule Zürich | Antibody specific for the ed-b domain of fibronectin, conjugates comprising said antibody, and their use for the detection and treatment of angiogenesis |
WO2001062298A2 (en) * | 2000-02-24 | 2001-08-30 | Philogen S.R.L. | Compositions and methods for treatment of angiogenesis in pathological lesions |
US7094750B2 (en) | 2000-05-09 | 2006-08-22 | Greenville Hospital System | Therapeutic pore-forming peptides |
WO2001096599A2 (en) * | 2000-06-15 | 2001-12-20 | Philogen S.R.L. | Methods for quantitative determination of b-fibronectin in biological fluids and tissues |
WO2002020563A2 (de) * | 2000-09-07 | 2002-03-14 | Schering Aktiengesellschaft | REZEPTOR DER EDb-FIBRONEKTIN-DOMÄNE (II) |
IT1317108B1 (it) * | 2000-12-06 | 2003-05-26 | Philogen Srl | Processo per la selezione di frammenti anticorporali anti-angiogenesi,frammenti anticorpali anti-angiogenesi cosi' ottenuti e loro uso. |
US7456146B2 (en) * | 2001-05-09 | 2008-11-25 | Ghc Research Development Corporation | Lytic peptide prodrugs |
AU2003210149B2 (en) | 2002-01-03 | 2008-10-09 | Bayer Schering Pharma Aktiengesellschaft | Conjugates comprising an antibody specific for the ED-B domain of fibronectin and their use for the detection and treatment of tumours |
US8491906B2 (en) * | 2002-03-11 | 2013-07-23 | Philogen S.P.A. | Selective targeting of tumor vasculature using antibody molecules |
SI2269656T1 (sl) | 2002-07-15 | 2014-11-28 | Board Of Regents, The University Of Texas System | Izbrana protitelesa, ki se veĹľejo na aminofosfolipide, in njihova uporaba v zdravljanju raka |
WO2004083249A2 (en) | 2003-03-14 | 2004-09-30 | Wyeth | Antibodies against human il-21 receptor and uses therefor |
DE10324447A1 (de) | 2003-05-28 | 2004-12-30 | Scil Proteins Gmbh | Generierung künstlicher Bindungsproteine auf der Grundlage von Ubiquitin |
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DK2299275T3 (da) | 2004-07-30 | 2018-05-07 | Adeza Biomedical Corp | Klassificering af onkoføtalt fibronectin niveau for graviditetsrelaterede indikationer |
US7785591B2 (en) * | 2004-10-14 | 2010-08-31 | Morphosys Ag | Identification and characterization of function-blocking anti-ED-B-fibronectin antibodies |
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EP1925664A1 (en) | 2006-11-15 | 2008-05-28 | Scil proteins GmbH | Artificial binding proteins based on a modified alpha helical region of ubiquitin |
US8253725B2 (en) * | 2007-12-28 | 2012-08-28 | St. Jude Medical, Atrial Fibrillation Division, Inc. | Method and system for generating surface models of geometric structures |
ATE548052T1 (de) * | 2008-01-17 | 2012-03-15 | Philogen Spa | Kombination aus einem anti-edb-fibronectin- antikörper-il-2-fusionsprotein und einem b-zellen bindenden molekül, b-zellen-vorläufern und/oder deren krebserregendem gegenspieler |
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IT1392027B1 (it) * | 2008-12-12 | 2012-02-09 | Castellani | Anticorpo monoclonale e suo uso per la identificazione della isoforma oncofetale della fibronettina (b-fn) a scopo diagnostico o terapeutico. |
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WO2011110490A1 (en) | 2010-03-09 | 2011-09-15 | Bayer Pharma Aktiengesellschaft | Process for the production of radioactively labelled scfv antibody fragments, kits and compositions |
WO2012171541A1 (en) | 2011-06-15 | 2012-12-20 | Scil Proteins Gmbh | Human fusion proteins comprising interferons and hetero-dimeric modified ubiquitin proteins |
US9492572B2 (en) | 2011-06-15 | 2016-11-15 | Scil Proteins Gmbh | Dimeric binding proteins based on modified ubiquitins |
WO2013186329A1 (en) | 2012-06-13 | 2013-12-19 | Scil Proteins Gmbh | Human fusion proteins comprising single chain tnfalpha and targeting domains |
WO2014094799A1 (en) | 2012-12-19 | 2014-06-26 | Scil-Proteins-Gmbh | Ubiquitin moieties as a means for prolonging serum half-life |
EP3029065B1 (en) * | 2013-06-06 | 2020-05-27 | Hefei Lifeon Pharmaceutical Co. Ltd. | Human antibody against ed-b domain of fibronectin and uses thereof |
WO2016124702A1 (en) | 2015-02-06 | 2016-08-11 | Scil Proteins Gmbh | Novel egfr binding proteins |
KR102064396B1 (ko) | 2015-07-16 | 2020-01-09 | 나피고 프로타인스 게엠베하 | 신규한 면역글로불린-결합 단백질 및 친화도 정제에서의 이의 용도 |
WO2017013136A1 (en) | 2015-07-20 | 2017-01-26 | Scil Proteins Gmbh | Novel binding proteins based on di-ubiquitin muteins and methods for generation |
CN108291915B (zh) * | 2015-11-16 | 2021-01-05 | 合肥立方制药股份有限公司 | Ed-b蛋白在诊断组织增生中的应用 |
CN109310780A (zh) | 2016-05-04 | 2019-02-05 | 纳维格蛋白质有限公司 | 包含肽接头的用于化学部分位点-特异性偶联的靶向化合物 |
JP7181612B2 (ja) | 2016-08-11 | 2022-12-01 | ナフィゴ プロテインズ ゲゼルシャフト ミット ベシュレンクテル ハフツング | アルカリ安定性免疫グロブリン結合タンパク質 |
WO2018073680A1 (en) | 2016-10-17 | 2018-04-26 | Pfizer Inc. | Anti-edb antibodies and antibody-drug conjugates |
CA3065153C (en) | 2017-06-07 | 2023-09-05 | Philogen S.P.A. | Vascular endothelial growth factor/anti-fibronectin antibody fusion proteins |
CN111148759B (zh) | 2017-09-30 | 2023-09-19 | 合肥立方制药股份有限公司 | 结合至纤维连接蛋白b结构域的蛋白 |
WO2019091918A1 (en) | 2017-11-07 | 2019-05-16 | Navigo Proteins Gmbh | Fusion proteins with specificity for ed-b and long serum half-life for diagnosis or treatment of cancer |
WO2020070150A1 (en) | 2018-10-02 | 2020-04-09 | Philogen S.P.A | Il2 immunoconjugates |
EP3660039A1 (en) | 2018-11-30 | 2020-06-03 | Philogen S.p.A. | Il2 immunoconjugates |
CR20220054A (es) | 2019-08-15 | 2022-06-06 | Janssen Biotech Inc | Materiales y métodos para fragmentos variables de cadena única mejorado |
KR20220130687A (ko) | 2019-12-11 | 2022-09-27 | 시락 게엠베하 인터내셔날 | Ltbr 및 edb 결합 도메인을 포함하는 다중특이성 결합 분자 및 이의 용도 |
CN111171149B (zh) * | 2020-02-23 | 2021-09-07 | 北京康普美特创新医药科技有限责任公司 | 一种抗补体c5分子的人源化单链抗体及其应用 |
CN111234016B (zh) * | 2020-02-23 | 2021-09-07 | 北京康普美特创新医药科技有限责任公司 | 一种抗补体c5分子的全人源单克隆抗体及应用 |
KR102614063B1 (ko) | 2020-12-24 | 2023-12-19 | 대화제약 주식회사 | 엑스트라도메인 b 피브로넥틴에 특이적으로 결합하는 신규한 항체 |
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-
1996
- 1996-05-24 GB GB9610967A patent/GB9610967D0/en active Pending
-
1997
- 1997-05-23 AT AT97923243T patent/ATE361364T1/de active
- 1997-05-23 US US09/194,356 patent/US7273924B1/en not_active Expired - Fee Related
- 1997-05-23 JP JP54182897A patent/JP4750912B2/ja not_active Expired - Lifetime
- 1997-05-23 PT PT97923243T patent/PT906426E/pt unknown
- 1997-05-23 CZ CZ19983815A patent/CZ295531B6/cs not_active IP Right Cessation
- 1997-05-23 KR KR1020067006008A patent/KR100741452B1/ko not_active IP Right Cessation
- 1997-05-23 DE DE1997637683 patent/DE69737683T2/de not_active Expired - Lifetime
- 1997-05-23 TR TR1998/02416T patent/TR199802416T2/xx unknown
- 1997-05-23 PL PL97330075A patent/PL188557B1/pl not_active IP Right Cessation
- 1997-05-23 SI SI9730765T patent/SI0906426T1/sl unknown
- 1997-05-23 EA EA199801043A patent/EA004329B1/ru not_active IP Right Cessation
- 1997-05-23 ES ES97923243T patent/ES2286831T3/es not_active Expired - Lifetime
- 1997-05-23 HU HU0200546A patent/HUP0200546A2/hu unknown
- 1997-05-23 SK SK1612-98A patent/SK285916B6/sk not_active IP Right Cessation
- 1997-05-23 EP EP19970923243 patent/EP0906426B1/en not_active Expired - Lifetime
- 1997-05-23 IL IL12721697A patent/IL127216A0/xx active IP Right Grant
- 1997-05-23 AU AU29101/97A patent/AU729081B2/en not_active Expired
- 1997-05-23 BR BRPI9709350-5A patent/BR9709350B1/pt not_active IP Right Cessation
- 1997-05-23 UA UA98126836A patent/UA74129C2/uk unknown
- 1997-05-23 CN CNB971949026A patent/CN100447159C/zh not_active Expired - Lifetime
- 1997-05-23 NZ NZ33308397A patent/NZ333083A/xx not_active IP Right Cessation
- 1997-05-23 DK DK97923243T patent/DK0906426T3/da active
- 1997-05-23 CA CA 2256308 patent/CA2256308C/en not_active Expired - Lifetime
- 1997-05-23 WO PCT/GB1997/001412 patent/WO1997045544A1/en active IP Right Grant
- 1997-05-23 KR KR10-2005-7000518A patent/KR20050010081A/ko not_active Application Discontinuation
-
1998
- 1998-10-29 IS IS4883A patent/IS2508B/is unknown
- 1998-11-23 NO NO19985459A patent/NO324904B1/no not_active IP Right Cessation
- 1998-11-23 IL IL127216A patent/IL127216A/en not_active IP Right Cessation
- 1998-11-24 BG BG102950A patent/BG65138B1/bg unknown
-
1999
- 1999-12-14 HK HK99105868A patent/HK1020990A1/xx not_active IP Right Cessation
-
2007
- 2007-08-21 US US11/842,774 patent/US8703143B2/en not_active Expired - Fee Related
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2008
- 2008-08-07 JP JP2008204682A patent/JP2009050261A/ja active Pending
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2013
- 2013-10-04 US US14/046,224 patent/US9096670B2/en not_active Expired - Fee Related
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