BR9711241B8 - processo para fabricar uma composição polimérica para prevenir ou inibir a formação de aderências de tecidos ou para inibir sangramento - Google Patents

processo para fabricar uma composição polimérica para prevenir ou inibir a formação de aderências de tecidos ou para inibir sangramento

Info

Publication number
BR9711241B8
BR9711241B8 BRPI9711241A BR9711241A BR9711241B8 BR 9711241 B8 BR9711241 B8 BR 9711241B8 BR PI9711241 A BRPI9711241 A BR PI9711241A BR 9711241 A BR9711241 A BR 9711241A BR 9711241 B8 BR9711241 B8 BR 9711241B8
Authority
BR
Brazil
Prior art keywords
tissue
inhibit
polymeric composition
patient
making
Prior art date
Application number
BRPI9711241A
Other languages
English (en)
Other versions
BRPI9711241B1 (pt
BR9711241A (pt
Inventor
Edward Osawa A
J Reich Cary
G Wallace Donald
Vega Felix
S Shargill Narinder
Original Assignee
Fusion Medical Tech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27107390&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR9711241(B8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Fusion Medical Tech Inc filed Critical Fusion Medical Tech Inc
Publication of BR9711241A publication Critical patent/BR9711241A/pt
Publication of BRPI9711241B1 publication Critical patent/BRPI9711241B1/pt
Publication of BR9711241B8 publication Critical patent/BR9711241B8/pt

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001Use of materials characterised by their function or physical properties
    • A61L24/0015Medicaments; Biocides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001Use of materials characterised by their function or physical properties
    • A61L24/0031Hydrogels or hydrocolloids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52Hydrogels or hydrocolloids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54Biologically active materials, e.g. therapeutic substances
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/145Hydrogels or hydrocolloids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16Biologically active materials, e.g. therapeutic substances
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/418Agents promoting blood coagulation, blood-clotting agents, embolising agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Surgery (AREA)
  • Dispersion Chemistry (AREA)
  • Dermatology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Materials Engineering (AREA)
  • Vascular Medicine (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Prostheses (AREA)
  • Surgical Instruments (AREA)
  • Compositions Of Macromolecular Compounds (AREA)

Abstract

"composição polimérica fragmentada, processos para fabricar a mesma, selar um trato do tecido, inibir o sangramento em um sítio alvo no corpo de um paciente, liberar uma composição intumescível a um sítio alvo no tecido e aplicar uma composição polimérica em um sítio alvo no corpo de um paciente, conjunto de utensílios, aplicador contendo um hidrogel reticulado molecular, e, embalagem estéril" . géis moleculares reticulados compreendem uma variedade de polímeros biológicos e não biológicos, tais como proteínas, polissacarídeos e polímeros sintéticos. tais géis moleculares podem ser aplicados a sítios alvos no corpo de um paciente mediante a extrusão do gel através de um orifício no sítio alvo. alternativamente, os géis podem ser mecanicamente fragmentados e usados em artigos implantáveis, tais como implantes de seio. quando usado in vivo, as composições são úteis para inibir as aderências espinais e de outros tecidos pós-cirúrgicos, para enchimento de pedaços de tecidos, tratos de tecidos, cavidades do corpo, defeitos cirúrgicos, e outros.
BRPI9711241A 1996-08-27 1997-08-14 processo para fabricar uma composição polimérica para prevenir ou inibir a formação de aderências de tecidos ou para inibir sangramento BR9711241B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US70485296A 1996-08-27 1996-08-27
US08/903,674 US6063061A (en) 1996-08-27 1997-07-31 Fragmented polymeric compositions and methods for their use
PCT/US1997/015262 WO1998008550A1 (en) 1996-08-27 1997-08-14 Fragmented polymeric hydrogels for adhesion prevention and their preparation

Publications (3)

Publication Number Publication Date
BR9711241A BR9711241A (pt) 1999-08-17
BRPI9711241B1 BRPI9711241B1 (pt) 2016-12-20
BR9711241B8 true BR9711241B8 (pt) 2021-06-22

Family

ID=27107390

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI9711241A BR9711241B8 (pt) 1996-08-27 1997-08-14 processo para fabricar uma composição polimérica para prevenir ou inibir a formação de aderências de tecidos ou para inibir sangramento

Country Status (10)

Country Link
US (1) US6063061A (pt)
EP (1) EP0927053B1 (pt)
JP (3) JP4418535B2 (pt)
AU (1) AU719534B2 (pt)
BR (1) BR9711241B8 (pt)
CA (1) CA2264647C (pt)
DE (1) DE69720479T2 (pt)
IL (1) IL128496A (pt)
RU (1) RU2207882C2 (pt)
WO (1) WO1998008550A1 (pt)

Families Citing this family (237)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6071300A (en) * 1995-09-15 2000-06-06 Sub-Q Inc. Apparatus and method for percutaneous sealing of blood vessel punctures
US6183497B1 (en) * 1998-05-01 2001-02-06 Sub-Q, Inc. Absorbable sponge with contrasting agent
US6066325A (en) * 1996-08-27 2000-05-23 Fusion Medical Technologies, Inc. Fragmented polymeric compositions and methods for their use
US6063061A (en) * 1996-08-27 2000-05-16 Fusion Medical Technologies, Inc. Fragmented polymeric compositions and methods for their use
US8603511B2 (en) * 1996-08-27 2013-12-10 Baxter International, Inc. Fragmented polymeric compositions and methods for their use
US7320962B2 (en) 1996-08-27 2008-01-22 Baxter International Inc. Hemoactive compositions and methods for their manufacture and use
US6706690B2 (en) * 1999-06-10 2004-03-16 Baxter Healthcare Corporation Hemoactive compositions and methods for their manufacture and use
US7435425B2 (en) * 2001-07-17 2008-10-14 Baxter International, Inc. Dry hemostatic compositions and methods for their preparation
US8303981B2 (en) 1996-08-27 2012-11-06 Baxter International Inc. Fragmented polymeric compositions and methods for their use
US7871637B2 (en) * 1996-08-27 2011-01-18 Baxter International Inc. Dry hemostatic compositions and methods for their preparation
AT407117B (de) * 1997-09-19 2000-12-27 Immuno Ag Fibrinschwamm
US20010045575A1 (en) * 1998-05-01 2001-11-29 Mark Ashby Device and method for facilitating hemostasis of a biopsy tract
US6315753B1 (en) * 1998-05-01 2001-11-13 Sub-Q, Inc. System and method for facilitating hemostasis of blood vessel punctures with absorbable sponge
JP2003521270A (ja) * 1998-08-04 2003-07-15 フュージョン メディカル テクノロジーズ, インコーポレイテッド 経皮組織路閉塞アセンブリおよび方法
US6152943A (en) * 1998-08-14 2000-11-28 Incept Llc Methods and apparatus for intraluminal deposition of hydrogels
US6605294B2 (en) * 1998-08-14 2003-08-12 Incept Llc Methods of using in situ hydration of hydrogel articles for sealing or augmentation of tissue or vessels
US7790192B2 (en) 1998-08-14 2010-09-07 Accessclosure, Inc. Apparatus and methods for sealing a vascular puncture
US7347850B2 (en) * 1998-08-14 2008-03-25 Incept Llc Adhesion barriers applicable by minimally invasive surgery and methods of use thereof
GB9826658D0 (en) * 1998-12-03 1999-01-27 Univ London Tissue repair
US20080114092A1 (en) * 1998-12-04 2008-05-15 Incept Llc Adhesion barriers applicable by minimally invasive surgery and methods of use thereof
US6685694B2 (en) * 1999-07-23 2004-02-03 Vasca, Inc. Methods and kits for locking and disinfecting implanted catheters
US6679870B1 (en) * 1999-07-23 2004-01-20 Vasca, Inc. Methods and kits for locking and disinfecting implanted catheters
US6783546B2 (en) 1999-09-13 2004-08-31 Keraplast Technologies, Ltd. Implantable prosthetic or tissue expanding device
US6371984B1 (en) * 1999-09-13 2002-04-16 Keraplast Technologies, Ltd. Implantable prosthetic or tissue expanding device
US6984219B2 (en) * 1999-09-23 2006-01-10 Mark Ashby Depth and puncture control for blood vessel hemostasis system
WO2001056475A1 (en) * 2000-02-03 2001-08-09 Tissuemed Limited Device for the closure of a surgical puncture
GB0011169D0 (en) * 2000-05-10 2000-06-28 Reckitt & Colmann Prod Ltd Improvements in or relating to medicinal compositions
EP1328300B1 (en) * 2000-10-23 2005-01-05 Tissuemed Limited Self-adhesive hydratable matrix for topical therapeutic use
US9080146B2 (en) 2001-01-11 2015-07-14 Celonova Biosciences, Inc. Substrates containing polyphosphazene as matrices and substrates containing polyphosphazene with a micro-structured surface
US8187625B2 (en) 2001-03-12 2012-05-29 Boston Scientific Scimed, Inc. Cross-linked gelatin composition comprising a wetting agent
FI20010540A0 (fi) * 2001-03-16 2001-03-16 Yli Urpo Antti Komposiitti pehmyt- ja kovakudosvammojen korjaamiseksi ja mainitun komposiitin käyttö
US20020193812A1 (en) * 2001-05-04 2002-12-19 Concentric Medical Hydrogel vaso-occlusive device
US7008440B2 (en) * 2001-11-08 2006-03-07 Sub-Q, Inc. System and method for delivering hemostasis promoting material to a blood vessel puncture site by fluid pressure
US6592608B2 (en) * 2001-12-07 2003-07-15 Biopsy Sciences, Llc Bioabsorbable sealant
WO2003035722A1 (en) 2001-09-25 2003-05-01 Southwest Research Institute Methods for controlling peptide solubility, chemically modified peptides, and stable solvent systems for producing same
US7923431B2 (en) 2001-12-21 2011-04-12 Ferrosan Medical Devices A/S Haemostatic kit, a method of preparing a haemostatic agent and a method of promoting haemostatis
EP1478328B1 (en) 2002-01-28 2013-06-05 Keraplast Technologies Ltd. Bioactive keratin peptides
US6989437B2 (en) 2002-04-10 2006-01-24 Keraplast Technologies, Ltd. Methods for producing, films comprising, and methods for using heterogeneous crosslinked protein networks
US7001987B2 (en) 2002-04-22 2006-02-21 Keraplast Technologies, Ltd. Hydrogel with controllable mechanical, chemical, and biological properties and method for making same
US6914126B2 (en) 2002-04-10 2005-07-05 Keraplast Technologies, Ltd. Methods for producing, films comprising, and methods for using heterogenous crosslinked protein networks
US20080226723A1 (en) * 2002-07-05 2008-09-18 Celonova Biosciences, Inc. Loadable Polymeric Particles for Therapeutic Use in Erectile Dysfunction and Methods of Preparing and Using the Same
US7135027B2 (en) 2002-10-04 2006-11-14 Baxter International, Inc. Devices and methods for mixing and extruding medically useful compositions
AU2003302906B2 (en) * 2002-12-11 2009-04-02 Ferrosan Medical Devices A/S Gelatine-based materials as swabs
SE0302947D0 (sv) 2003-01-24 2003-11-07 Magle Ab A composition material for transmucosal delivery
SI1617823T1 (sl) * 2003-01-24 2019-07-31 Nicachet Ab Vrečka, ki obsega nikotinski sestavek za transmukozno dajanje
BRPI0408853A (pt) * 2003-04-04 2006-04-04 Tissuemed Ltd formulações para adesão ao tecido
US9289195B2 (en) 2003-06-04 2016-03-22 Access Closure, Inc. Auto-retraction apparatus and methods for sealing a vascular puncture
US7331979B2 (en) * 2003-06-04 2008-02-19 Access Closure, Inc. Apparatus and methods for sealing a vascular puncture
US8834864B2 (en) * 2003-06-05 2014-09-16 Baxter International Inc. Methods for repairing and regenerating human dura mater
WO2005000374A1 (ja) * 2003-06-30 2005-01-06 Denki Kagaku Kogyo Kabushiki Kaisha 脊椎・脊髄手術用癒着防止材
US20050033157A1 (en) * 2003-07-25 2005-02-10 Klein Dean A. Multi-modality marking material and method
US8440225B2 (en) * 2003-08-07 2013-05-14 Ethicon, Inc. Process of making flowable hemostatic compositions and devices containing such compositions
US7927626B2 (en) * 2003-08-07 2011-04-19 Ethicon, Inc. Process of making flowable hemostatic compositions and devices containing such compositions
US20060019868A1 (en) * 2004-01-30 2006-01-26 Pendharkar Sanyog M Hemostatic compositions and devices
US20050036955A1 (en) * 2003-08-13 2005-02-17 Degould Michael D. Bioresorbable tooth extraction socket dressing
WO2005046746A2 (en) * 2003-11-10 2005-05-26 Angiotech International Ag Medical implants and fibrosis-inducing agents
US20050208095A1 (en) * 2003-11-20 2005-09-22 Angiotech International Ag Polymer compositions and methods for their use
US7875043B1 (en) 2003-12-09 2011-01-25 Sub-Q, Inc. Cinching loop
AR054637A1 (es) * 2004-01-30 2007-07-11 Ferrosan As Aerosoles y composiciones hemostaticas
US7109163B2 (en) * 2004-01-30 2006-09-19 Ethicon, Inc. Hemostatic compositions and devices
EP1753860B1 (en) * 2004-02-20 2012-04-11 Isto Technologies Inc. Intervertebral disc repair and methods therefor
US20060275273A1 (en) * 2004-02-20 2006-12-07 Seyedin Mitchell S Intervertebral Disc Repair, Methods and Devices Therefor
US20050187429A1 (en) * 2004-02-23 2005-08-25 Poppas Dix P. Vaginal rejuvenation
US20050226936A1 (en) * 2004-04-08 2005-10-13 Q-Med Ab Method of soft tissue augmentation
US8119160B2 (en) * 2004-06-29 2012-02-21 Ethicon, Inc. Hemostatic compositions and devices
US8021684B2 (en) * 2004-07-09 2011-09-20 Ferrosan Medical Devices A/S Haemostatic composition comprising hyaluronic acid
BRPI0514106A (pt) * 2004-08-03 2008-05-27 Tissuemed Ltd materiais adesivos a tecidos
WO2007001339A2 (en) 2004-08-17 2007-01-04 Wake Forest University Health Sciences Ambient stored blood plasma expanders
US8348971B2 (en) 2004-08-27 2013-01-08 Accessclosure, Inc. Apparatus and methods for facilitating hemostasis within a vascular puncture
DE102004047115B9 (de) 2004-09-27 2007-10-31 Universität Hamburg Verfahren zur Herstellung einer Wundauflage
US7235592B2 (en) 2004-10-12 2007-06-26 Zimmer Gmbh PVA hydrogel
US9107850B2 (en) * 2004-10-25 2015-08-18 Celonova Biosciences, Inc. Color-coded and sized loadable polymeric particles for therapeutic and/or diagnostic applications and methods of preparing and using the same
BRPI0518383A2 (pt) 2004-10-25 2008-11-18 Polyzenix Gmbh partÍculas polimÉricas carregÁveis para aplicaÇÕes terepÊuticas e/ou diagnàstico e mÉtodos para preparar e usar as mesmas
US20210299056A9 (en) 2004-10-25 2021-09-30 Varian Medical Systems, Inc. Color-Coded Polymeric Particles of Predetermined Size for Therapeutic and/or Diagnostic Applications and Related Methods
US9114162B2 (en) 2004-10-25 2015-08-25 Celonova Biosciences, Inc. Loadable polymeric particles for enhanced imaging in clinical applications and methods of preparing and using the same
US8262693B2 (en) * 2004-11-05 2012-09-11 Accessclosure, Inc. Apparatus and methods for sealing a vascular puncture
US8663225B2 (en) 2004-11-12 2014-03-04 Medtronic, Inc. Hydrogel bone void filler
US7530578B2 (en) * 2004-11-17 2009-05-12 Continental Commercial Products, Llc Step-on receptacle with tip prevention
WO2006091706A1 (en) 2005-02-23 2006-08-31 Zimmer Technology, Inc. Blend hydrogels and methods of making
US7857856B2 (en) * 2005-03-15 2010-12-28 Warsaw Ortho Pedic, Inc. Composite spinal nucleus implant with water absorption and swelling capabilities
US20060222596A1 (en) 2005-04-01 2006-10-05 Trivascular, Inc. Non-degradable, low swelling, water soluble radiopaque hydrogel polymer
US8257438B2 (en) * 2005-04-12 2012-09-04 Warsaw Orthopedic, Inc. Methods and devices for preserving motion in an articulating prosthetic disc
US8414907B2 (en) 2005-04-28 2013-04-09 Warsaw Orthopedic, Inc. Coatings on medical implants to guide soft tissue healing
US9119901B2 (en) 2005-04-28 2015-09-01 Warsaw Orthopedic, Inc. Surface treatments for promoting selective tissue attachment to medical impants
EP2664340B1 (en) 2005-06-24 2020-02-12 Duke University A direct drug delivery system based on thermally responsive biopolymers
EP1940439B1 (en) 2005-08-11 2010-10-27 University Of Saskatchewan Reducing post-operative adhesion formation with intraperitoneal glutamine
US20070074980A1 (en) * 2005-09-02 2007-04-05 Bankoski Brian R Implant rehydration packages and methods of use
US8920827B2 (en) 2005-10-21 2014-12-30 Wake Forest University Health Sciences Keratin bioceramic compositions
JP2009513286A (ja) * 2005-10-28 2009-04-02 バクスター・インターナショナル・インコーポレイテッド アプリケータおよびその使用方法
US9101742B2 (en) * 2005-10-28 2015-08-11 Baxter International Inc. Gastrointestinal applicator and method of using same
US20070110788A1 (en) * 2005-11-14 2007-05-17 Hissong James B Injectable formulation capable of forming a drug-releasing device
AU2006321809A1 (en) 2005-12-07 2007-06-14 Zimmer, Inc. Methods of bonding or modifying hydrogels using irradiation
US20130172274A1 (en) 2005-12-20 2013-07-04 Duke University Methods and compositions for delivering active agents with enhanced pharmacological properties
US8841255B2 (en) * 2005-12-20 2014-09-23 Duke University Therapeutic agents comprising fusions of vasoactive intestinal peptide and elastic peptides
ES2779992T3 (es) 2005-12-20 2020-08-21 Univ Duke Métodos y composiciones para suministrar agentes activos con propiedades farmacológicas potenciadas
JP2007177244A (ja) 2005-12-22 2007-07-12 Zimmer Inc ペルフルオロシクロブタン架橋ハイドロゲル
JP2007177074A (ja) * 2005-12-28 2007-07-12 Tohoku Univ 組成物およびその製造方法
WO2007088402A2 (en) 2006-02-03 2007-08-09 Tissuemed Limited Tissue-adhesive materials
US7892573B2 (en) 2006-02-10 2011-02-22 Wake Forest University Health Sciences Nerve regeneration employing keratin biomaterials
US9149566B2 (en) 2006-02-17 2015-10-06 Wake Forest University Health Sciences Coatings and biomedical implants formed from keratin biomaterials
US8273702B2 (en) 2006-02-17 2012-09-25 Wake Forest University Health Sciences Wound healing compositions containing keratin biomaterials
US20090018575A1 (en) * 2006-03-01 2009-01-15 Tissuemed Limited Tissue-adhesive formulations
US8110242B2 (en) 2006-03-24 2012-02-07 Zimmer, Inc. Methods of preparing hydrogel coatings
US8795709B2 (en) 2006-03-29 2014-08-05 Incept Llc Superabsorbent, freeze dried hydrogels for medical applications
CA2650473C (en) * 2006-04-24 2013-06-18 Incept, Llc Protein crosslinkers, crosslinking methods and applications thereof
US7993675B2 (en) * 2006-05-10 2011-08-09 Medtronic Xomed, Inc. Solvating system and sealant for medical use in the sinuses and nasal passages
US7959943B2 (en) * 2006-05-10 2011-06-14 Medtronics Xomed, Inc. Solvating system and sealant for medical use in the middle or inner ear
US7976873B2 (en) * 2006-05-10 2011-07-12 Medtronic Xomed, Inc. Extracellular polysaccharide solvating system for treatment of bacterial ear conditions
US20070264296A1 (en) * 2006-05-10 2007-11-15 Myntti Matthew F Biofilm extracellular polysachharide solvating system
US7872068B2 (en) * 2006-05-30 2011-01-18 Incept Llc Materials formable in situ within a medical device
CN101454030B (zh) * 2006-05-31 2013-06-26 巴克斯特国际公司 用于脊柱外科手术中定向细胞向内生长和控制组织再生的方法
US8167847B2 (en) 2006-06-22 2012-05-01 Excelsior Medical Corporation Antiseptic cap and antiseptic cap equipped plunger and syringe barrel assembly
TWI436793B (zh) 2006-08-02 2014-05-11 Baxter Int 快速作用之乾密封膠及其使用和製造方法
US7671014B2 (en) * 2006-08-14 2010-03-02 Warsaw Orthopedic, Inc. Flowable carrier matrix and methods for delivering to a patient
AU2007292926A1 (en) * 2006-09-08 2008-03-13 Symphony Medical, Inc. Intramyocardial patterning for treating localized anomalies of the heart
US20090012413A1 (en) * 2006-09-08 2009-01-08 Sabbah Hani N Cardiac patterning for improving diastolic function
US8617204B2 (en) * 2006-09-13 2013-12-31 Accessclosure, Inc. Apparatus and methods for sealing a vascular puncture
FR2909285A1 (fr) * 2006-12-01 2008-06-06 Anteis Sa "utilisation d'un gel anti-adhesif et anti fibrotique"
CN101854960B (zh) 2006-12-15 2014-06-25 生命连结有限公司 明胶-转谷氨酰胺酶止血敷料和密封材料
US8088095B2 (en) 2007-02-08 2012-01-03 Medtronic Xomed, Inc. Polymeric sealant for medical use
CA2578647A1 (en) * 2007-02-15 2008-08-15 University Of Saskatchewan Reducing post-operative adhesion formation with intraperitoneal glutamine
US8932560B2 (en) 2007-09-04 2015-01-13 University of Maryland, College Parke Advanced functional biocompatible polymeric matrix used as a hemostatic agent and system for damaged tissues and cells
WO2008127607A2 (en) * 2007-04-11 2008-10-23 Henry Ford Health System Cardiac repair, resizing and reshaping using the venous system of the heart
DE102007038125A1 (de) * 2007-08-03 2009-02-05 Aesculap Ag Kombination zum Verkleben von biologischen Geweben
US7731988B2 (en) 2007-08-03 2010-06-08 Zimmer, Inc. Multi-polymer hydrogels
GB0715514D0 (en) * 2007-08-10 2007-09-19 Tissuemed Ltd Coated medical devices
US8062739B2 (en) 2007-08-31 2011-11-22 Zimmer, Inc. Hydrogels with gradient
US7993367B2 (en) * 2007-09-28 2011-08-09 Accessclosure, Inc. Apparatus and methods for sealing a vascular puncture
US20090111763A1 (en) * 2007-10-26 2009-04-30 Celonova Biosciences, Inc. Loadable polymeric particles for bone augmentation and methods of preparing and using the same
US20090110738A1 (en) * 2007-10-26 2009-04-30 Celonova Biosciences, Inc. Loadable Polymeric Particles for Cosmetic and Reconstructive Tissue Augmentation Applications and Methods of Preparing and Using the Same
US20090110731A1 (en) * 2007-10-30 2009-04-30 Celonova Biosciences, Inc. Loadable Polymeric Microparticles for Therapeutic Use in Alopecia and Methods of Preparing and Using the Same
TWI461227B (zh) 2007-10-30 2014-11-21 Baxter Int 再生生物功能性膠原生物基質用來治療內臟或體壁缺陷的用途
WO2009059217A2 (en) * 2007-11-02 2009-05-07 Incept, Llc Apparatus and methods for sealing a vascular puncture
US7947784B2 (en) 2007-11-16 2011-05-24 Zimmer, Inc. Reactive compounding of hydrogels
US8299316B2 (en) * 2007-12-18 2012-10-30 Ethicon, Inc. Hemostatic device
US8034362B2 (en) 2008-01-04 2011-10-11 Zimmer, Inc. Chemical composition of hydrogels for use as articulating surfaces
CN104888263B (zh) * 2008-01-14 2018-11-30 北京环球利康科技有限公司 生物相容性止血、防粘连、促愈合、外科封闭的变性淀粉材料
US8642831B2 (en) * 2008-02-29 2014-02-04 Ferrosan Medical Devices A/S Device for promotion of hemostasis and/or wound healing
AU2009232000B2 (en) * 2008-04-03 2014-12-11 Baxter International Inc. Hemostatic microspheres
US8029533B2 (en) * 2008-04-04 2011-10-04 Accessclosure, Inc. Apparatus and methods for sealing a vascular puncture
US9364206B2 (en) 2008-04-04 2016-06-14 Access Closure, Inc. Apparatus and methods for sealing a vascular puncture
US8801665B2 (en) * 2008-04-10 2014-08-12 Henry Ford Health System Apparatus and method for controlled depth of injection into myocardial tissue
US20090259210A1 (en) * 2008-04-10 2009-10-15 Sabbah Hani N Method, apparatus and kits for forming structural members within the cardiac venous system
RU2513142C2 (ru) 2008-06-12 2014-04-20 Медтроник Ксомед Инк. Способ лечения хронических ран
WO2009153748A2 (en) * 2008-06-18 2009-12-23 Lifebond Ltd Methods and devices for use with sealants
AU2009261559B2 (en) * 2008-06-18 2014-01-16 Lifebond Ltd Improved cross-linked compositions
EP2303341A2 (en) * 2008-06-18 2011-04-06 Lifebond Ltd A method for enzymatic cross-linking of a protein
EP4074327A1 (en) 2008-06-27 2022-10-19 Duke University Therapeutic agents comprising elastin-like peptides
CA2734269A1 (en) 2008-08-26 2010-03-11 St. Jude Medical, Inc. Method and system for sealing percutaneous punctures
JP5702723B2 (ja) 2008-09-04 2015-04-15 ザ ジェネラル ホスピタル コーポレイション 声帯および軟組織の増強および修復用ヒドロゲル
EP2346324A4 (en) 2008-10-06 2012-10-10 Microbial Defense Systems Llc ANTIMICROBIAL COMPOSITION AND METHODS OF MAKING AND USING
JP2012508618A (ja) 2008-11-12 2012-04-12 アクセスクロージャー,インク. 脈管穿刺を閉鎖する装置及び方法
WO2010093882A1 (en) 2009-02-13 2010-08-19 Wake Forest University Health Sciences Keratin biomaterials for cell culture and methods of use
AU2010246115A1 (en) 2009-05-04 2011-12-08 Incept. Llc Biomaterials for track and puncture closure
US9039783B2 (en) 2009-05-18 2015-05-26 Baxter International, Inc. Method for the improvement of mesh implant biocompatibility
AU2010262058B2 (en) * 2009-06-16 2013-08-29 Baxter Healthcare S.A. Hemostatic sponge
JP2011025013A (ja) * 2009-06-25 2011-02-10 Doshisha 癒着防止材及びその製造方法
WO2011020091A1 (en) 2009-08-14 2011-02-17 Phasebio Pharmaceuticals, Inc. Modified vasoactive intestinal peptides
US9649331B2 (en) * 2009-08-27 2017-05-16 Ara Medical Llc Sprayable polymers as adhesion barriers
CA2780274C (en) 2009-11-09 2018-06-26 Spotlight Technology Partners Llc Fragmented hydrogels
AU2010314992B2 (en) 2009-11-09 2016-09-15 Spotlight Technology Partners Llc Polysaccharide based hydrogels
US8668899B2 (en) 2009-11-13 2014-03-11 University Of Maryland, College Park Advanced functional biocompatible foam used as a hemostatic agent for compressible and non-compressible acute wounds
EP2512540B1 (en) 2009-12-15 2019-08-07 Incept, LLC Implants and biodegradable fiducial markers
CA2784432C (en) * 2009-12-16 2019-01-15 Baxter Healthcare S.A. Hemostatic sponge
CN102711853B (zh) 2009-12-22 2015-05-20 生命连结有限公司 用于控制交联基质的性质的酶交联剂的改性
US9198568B2 (en) 2010-03-04 2015-12-01 The General Hospital Corporation Methods and systems of matching voice deficits with a tunable mucosal implant to restore and enhance individualized human sound and voice production
AU2011222540B2 (en) 2010-03-05 2016-09-29 Wake Forest University Health Sciences Controlled delivery system
WO2011112575A1 (en) 2010-03-08 2011-09-15 Wake Forest University Health Sciences Keratin biomaterials for treatment of ischemia
SA111320355B1 (ar) 2010-04-07 2015-01-08 Baxter Heathcare S A إسفنجة لايقاف النزف
GB201008404D0 (en) * 2010-05-20 2010-07-07 Fujifilm Mfg Europe Bv Hemostatic compositions
CN102917691A (zh) 2010-06-01 2013-02-06 巴克斯特国际公司 用于生产干燥、稳定的止血组合物的方法
CA2801116C (en) 2010-06-01 2019-02-12 Baxter International Inc. Process for making dry and stable hemostatic compositions
KR20130083393A (ko) * 2010-06-01 2013-07-22 백스터 인터내셔널 인코포레이티드 건조 및 안정한 지혈 조성물의 제조 방법
DK2600910T3 (en) 2010-08-05 2016-04-04 Lifebond Ltd Wound dressings and adhesives COMPREHENSIVE DRYING FORMATIONS
JP5721379B2 (ja) * 2010-09-21 2015-05-20 学校法人同志社 親水性高分子を含む自動縫合器用縫合補強材
AU2011329839B2 (en) 2010-11-17 2016-12-08 Wake Forest University Health Sciences Keratin compositions for treatment of bone deficiency or injury
KR101272484B1 (ko) * 2011-01-19 2013-06-10 세원셀론텍(주) 방사선 가교화된 콜라겐 겔 및 그 제조방법과 사용방법
EP2665425B1 (en) 2011-01-19 2018-08-22 Access Closure, Inc. Apparatus and methods for sealing a vascular puncture
US9820728B2 (en) 2011-01-19 2017-11-21 Access Closure, Inc. Apparatus and methods for sealing a vascular puncture
EP2484387A1 (en) 2011-02-03 2012-08-08 Q-Med AB Hyaluronic acid composition
WO2012122044A2 (en) 2011-03-04 2012-09-13 Orthovita, Inc. Flowable collagen-based hemostat and methods of use
JP2014511694A (ja) 2011-04-03 2014-05-19 ザ ジェネラル ホスピタル コーポレーション ドゥーイング ビジネス アズ マサチューセッツ ジェネラル ホスピタル 修飾型rna(mod−rna)を使用する効率的なインビボタンパク質発現
US10653133B2 (en) 2011-05-10 2020-05-19 Next Science IP Holdings Pty Ltd Antimicrobial solid and methods of making and using same
US9386968B2 (en) 2011-05-11 2016-07-12 Access Closure, Inc. Apparatus and methods for sealing a vascular puncture
US9561262B2 (en) 2011-06-06 2017-02-07 Phasebio Pharmaceuticals, Inc. Use of modified vasoactive intestinal peptides in the treatment of hypertension
US9149511B2 (en) 2011-06-30 2015-10-06 Ethicon, Inc. Procoagulant peptides and their derivatives and uses therefor
CN103732265B (zh) * 2011-08-02 2016-10-12 大日精化工业株式会社 防粘连用医用材料及其制造方法
ES2938566T3 (es) 2011-10-11 2023-04-12 Baxter Int Composiciones hemostaticas
CA2851321C (en) 2011-10-11 2020-07-07 Baxter International Inc. Hemostatic compositions
JP6195567B2 (ja) 2011-10-11 2017-09-13 バクスター・インターナショナル・インコーポレイテッドBaxter International Incorp0Rated 止血組成物
US20130096082A1 (en) 2011-10-11 2013-04-18 Baxter Healthcare S.A. Hemostatic compositions
US20130108671A1 (en) * 2011-10-27 2013-05-02 Baxter Healthcare S.A. Hemostatic compositions
TW201332567A (zh) 2011-10-27 2013-08-16 Baxter Int 止血組成物
CA2858161C (en) 2011-12-05 2020-03-10 Incept, Llc Medical organogel processes and compositions
US20130202675A1 (en) 2012-02-03 2013-08-08 Dynasil Biomedical Corporation Systems and methods for the fabrication of tissue patches
CA2865349C (en) 2012-03-06 2021-07-06 Ferrosan Medical Devices A/S Pressurized container containing haemostatic paste
US8721680B2 (en) 2012-03-23 2014-05-13 Accessclosure, Inc. Apparatus and methods for sealing a vascular puncture
US9757105B2 (en) 2012-03-23 2017-09-12 Accessclosure, Inc. Apparatus and methods for sealing a vascular puncture
KR20130134447A (ko) * 2012-05-31 2013-12-10 리젠프라임 주식회사 신규한 나노섬유막 및 이의 제조방법
EP2977066A3 (en) 2012-06-12 2016-07-27 Ferrosan Medical Devices A/S Dry haemostatic composition
WO2014160136A1 (en) 2013-03-13 2014-10-02 University Of Maryland, Office Of Technology Commercialization Advanced functional biocompatible polymer putty used as a hemostatic agent for treating damaged tissue and cells
BR112015030612B1 (pt) 2013-06-21 2020-07-21 Ferrosan Medical Devices A/S método para preparar uma composição seca
EP3470094B1 (en) 2013-12-11 2020-07-22 Ferrosan Medical Devices A/S Dry composition comprising an extrusion enhancer
AU2015255752B2 (en) 2014-05-08 2020-07-23 Immunoforge Co., Ltd. Methods and compositions for treating Cystic Fibrosis
JP6651500B2 (ja) * 2014-07-17 2020-02-19 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 生物医学的応用のための制御可能な自己アニーリング型ミクロゲル粒子
CA2960309A1 (en) 2014-10-13 2016-04-21 Ferrosan Medical Devices A/S Dry composition for use in haemostasis and wound healing
RU2705905C2 (ru) 2014-12-24 2019-11-12 Ферросан Медикал Дивайсиз А/С Шприц для удерживания и смешивания первого и второго веществ
RU2606990C2 (ru) * 2014-12-26 2017-01-10 Общество с ограниченной ответственностью "Проект Экопак" Биоразлагаемое вещество на основе возобновляемого сырья
US10688156B2 (en) 2015-02-09 2020-06-23 Phasebio Pharmaceuticals, Inc. Methods and compositions for treating muscle disease and disorders
CN104892864B (zh) * 2015-06-03 2017-09-22 西北师范大学 一种角蛋白‑海藻酸钠复合微孔凝胶的制备及作为药物载体的应用
CN104861179B (zh) * 2015-06-03 2017-09-12 西北师范大学 一种羽毛角蛋白‑海藻酸钠复合高分子双敏感水凝胶的制备及作为药物载体的应用
CN107771093B (zh) 2015-07-03 2021-06-15 弗罗桑医疗设备公司 用于混合两种组分和用于在存储条件下保持真空的注射器
US10660945B2 (en) 2015-08-07 2020-05-26 Victor Matthew Phillips Flowable hemostatic gel composition and its methods of use
US9833538B2 (en) 2015-08-07 2017-12-05 Xcede Technologies, Inc. Adhesive compositions and related methods
US10751444B2 (en) 2015-08-07 2020-08-25 Victor Matthew Phillips Flowable hemostatic gel composition and its methods of use
CA2994959A1 (en) 2015-08-07 2017-02-16 Xcede Technologies, Inc. Adhesive compositions and related methods
US9540548B1 (en) 2015-08-07 2017-01-10 Xcede Technologies, Inc. Adhesive compositions and related methods
MX2018002649A (es) 2015-09-01 2018-06-20 Baxter Int Material hemostatico.
US11931480B2 (en) 2016-02-16 2024-03-19 The Regents Of The University Of California Microporous annealed particle gels and methods of use
WO2017149584A1 (ja) * 2016-02-29 2017-09-08 川澄化学工業株式会社 癒着防止材
RU2628809C1 (ru) * 2016-06-30 2017-08-22 Федеральное государственное бюджетное учреждение Гематологический научный центр Министерства здравоохранения Российской Федерации (ФГБУ ГНЦ Минздрава России) Гемостатическая губка и способ ее получения
EP3562523A4 (en) 2016-12-29 2020-09-30 Tempo Therapeutics, Inc. PROCESSES AND SYSTEMS FOR THE TREATMENT OF A MEDICAL IMPLANT SITE
US11679177B2 (en) 2017-08-08 2023-06-20 Baxter International Inc. Polymeric compositions, delivery devices, and methods
MX2020004180A (es) 2017-11-03 2020-08-03 Baxter Int Composiciones polimericas, dispositivos de administracion y sus metodos.
MX2020006856A (es) 2017-12-29 2020-08-24 Baxter Int Trombina secada por aspersion y metodos de uso y preparacion de trombina secada por aspersion.
US11534384B2 (en) * 2017-12-29 2022-12-27 Matex Lab S.P.A. Method to prepare a filler with hyaluronic acid base comprising a neutralization step
CN108314790A (zh) * 2018-03-16 2018-07-24 东华大学 一种用于组织粘合剂的光交联巯基壳聚糖-聚乙二醇甲基丙烯酸酯水凝胶及其制备方法
CN108853598A (zh) * 2018-03-23 2018-11-23 中南大学湘雅二医院 一种自体生物蛋白水凝胶的制备及其在视网膜手术中的应用
CN108498871A (zh) * 2018-03-23 2018-09-07 中南大学湘雅二医院 一种自体生物蛋白水凝胶的制备及其在眼科的应用
ES2968412T3 (es) 2018-05-09 2024-05-09 Ferrosan Medical Devices As Método para preparar una composición hemostática
US11998654B2 (en) 2018-07-12 2024-06-04 Bard Shannon Limited Securing implants and medical devices
JP7043369B2 (ja) * 2018-08-24 2022-03-29 日立Geニュークリア・エナジー株式会社 耐放射線性ハイドロゲル材およびその製造方法
JP7042730B2 (ja) 2018-10-31 2022-03-28 株式会社ハイレックスコーポレーション 生体内非分解性癒着阻止材
CN109529098A (zh) * 2018-12-03 2019-03-29 广州润虹医药科技股份有限公司 一种外科医用粘合剂
US11739166B2 (en) 2020-07-02 2023-08-29 Davol Inc. Reactive polysaccharide-based hemostatic agent
KR102441137B1 (ko) * 2022-02-07 2022-09-06 김환철 분해속도 조절이 가능한 에테르기를 포함하는 생체적합성 고분자 하이드로겔
WO2024154679A1 (ja) * 2023-01-16 2024-07-25 株式会社大塚製薬工場 癒着防止材

Family Cites Families (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4013078A (en) * 1974-11-25 1977-03-22 Feild James Rodney Intervertebral protector means
DE3036033A1 (de) * 1980-09-24 1982-05-06 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen Wundbehandlungsmittel in pulverform und verfahren zu seiner herstellung
DE3105624A1 (de) * 1981-02-16 1982-09-02 Hormon-Chemie München GmbH, 8000 München Material zum abdichten und heilen von wunden
JPS60222045A (ja) * 1984-04-20 1985-11-06 日立化成工業株式会社 血管塞栓剤
SE456346B (sv) * 1984-07-23 1988-09-26 Pharmacia Ab Gel for att forhindra adhesion mellan kroppsvevnader och sett for dess framstellning
GB8422950D0 (en) * 1984-09-11 1984-10-17 Warne K J Hydrogel
JPS61122222A (ja) * 1984-11-19 1986-06-10 Koken:Kk コラ−ゲン又はゼラチンとプロタミンとよりなる止血剤
US4600533A (en) * 1984-12-24 1986-07-15 Collagen Corporation Collagen membranes for medical use
US5007916A (en) * 1985-08-22 1991-04-16 Johnson & Johnson Medical, Inc. Method and material for prevention of surgical adhesions
US4803075A (en) * 1986-06-25 1989-02-07 Collagen Corporation Injectable implant composition having improved intrudability
US5080893A (en) * 1988-05-31 1992-01-14 University Of Florida Method for preventing surgical adhesions using a dilute solution of polymer
US5017229A (en) * 1990-06-25 1991-05-21 Genzyme Corporation Water insoluble derivatives of hyaluronic acid
US5140016A (en) * 1988-05-31 1992-08-18 University Of Florida Method and composition for preventing surgical adhesions using a dilute solution of polymer
US5350573A (en) * 1988-05-31 1994-09-27 University Of Florida Research Foundation, Inc. Method and composition for preventing surgical adhesions
US5135751A (en) * 1988-11-16 1992-08-04 Mediventures Incorporated Composition for reducing postsurgical adhesions
US5126141A (en) * 1988-11-16 1992-06-30 Mediventures Incorporated Composition and method for post-surgical adhesion reduction with thermo-irreversible gels of polyoxyalkylene polymers and ionic polysaccharides
US4891359A (en) * 1988-12-08 1990-01-02 Johnson & Johnson Patient Care, Inc. Hemostatic collagen paste composition
US5196185A (en) * 1989-09-11 1993-03-23 Micro-Collagen Pharmaceutics, Ltd. Collagen-based wound dressing and method for applying same
US5061274A (en) * 1989-12-04 1991-10-29 Kensey Nash Corporation Plug device for sealing openings and method of use
US5219328A (en) * 1990-01-03 1993-06-15 Cryolife, Inc. Fibrin sealant delivery method
US5134229A (en) * 1990-01-12 1992-07-28 Johnson & Johnson Medical, Inc. Process for preparing a neutralized oxidized cellulose product and its method of use
JPH0813750B2 (ja) * 1990-03-01 1996-02-14 持田製薬株式会社 経口用トロンビン製剤
US5634943A (en) * 1990-07-12 1997-06-03 University Of Miami Injectable polyethylene oxide gel implant and method for production
US5192300A (en) * 1990-10-01 1993-03-09 Quinton Instrument Company Insertion assembly and method of inserting a vessel plug into the body of a patient
US5108421A (en) * 1990-10-01 1992-04-28 Quinton Instrument Company Insertion assembly and method of inserting a vessel plug into the body of a patient
US5129882A (en) * 1990-12-27 1992-07-14 Novoste Corporation Wound clotting device and method of using same
US5605938A (en) * 1991-05-31 1997-02-25 Gliatech, Inc. Methods and compositions for inhibition of cell invasion and fibrosis using dextran sulfate
NL9101051A (nl) * 1991-06-18 1993-01-18 Ashridge Ag Sluitinrichting voor een bloedvat of dergelijke.
US5204382A (en) * 1992-02-28 1993-04-20 Collagen Corporation Injectable ceramic compositions and methods for their preparation and use
DK0632820T3 (da) * 1992-02-28 2000-10-02 Collagen Corp Højkoncentrerede, homogeniserede collagensammensætninger
WO1993016657A1 (en) * 1992-02-28 1993-09-02 Collagen Corporation Injectable ceramic compositions and methods for their preparation and use
US5468505A (en) * 1992-02-28 1995-11-21 Board Of Regents, The University Of Texas System Local delivery of fibrinolysis enhancing agents
EP0637226A4 (en) * 1992-04-23 1995-06-14 Scimed Life Systems Inc DEVICE AND METHOD FOR CLOSING VASCULAR POINTS.
US5413571A (en) * 1992-07-16 1995-05-09 Sherwood Medical Company Device for sealing hemostatic incisions
DE69330909T2 (de) * 1992-11-12 2002-06-20 Neville Alleyne Einrichtung zum schutz des herzens
WO1994027630A1 (fr) * 1993-05-31 1994-12-08 Kaken Pharmaceutical Co., Ltd. Preparation de gel a base de gelatine reticulee contenant un facteur de croissance de fibroblaste de base
FR2715309B1 (fr) * 1994-01-24 1996-08-02 Imedex Composition adhésive, à usage chirurgical, à base de collagène modifié par coupure oxydative et non réticulé.
US5531759A (en) * 1994-04-29 1996-07-02 Kensey Nash Corporation System for closing a percutaneous puncture formed by a trocar to prevent tissue at the puncture from herniating
US5599735A (en) * 1994-08-01 1997-02-04 Texas Instruments Incorporated Method for doped shallow junction formation using direct gas-phase doping
US5516532A (en) * 1994-08-05 1996-05-14 Children's Medical Center Corporation Injectable non-immunogenic cartilage and bone preparation
US5677284A (en) * 1995-06-06 1997-10-14 Regen Biologics, Inc. Charged collagen particle-based delivery matrix
US5902832A (en) * 1996-08-20 1999-05-11 Menlo Care, Inc. Method of synthesizing swollen hydrogel for sphincter augmentation
US6063061A (en) * 1996-08-27 2000-05-16 Fusion Medical Technologies, Inc. Fragmented polymeric compositions and methods for their use

Also Published As

Publication number Publication date
JP2002515086A (ja) 2002-05-21
DE69720479D1 (de) 2003-05-08
CA2264647A1 (en) 1998-03-05
JP4842713B2 (ja) 2011-12-21
US6063061A (en) 2000-05-16
AU719534B2 (en) 2000-05-11
BRPI9711241B1 (pt) 2016-12-20
JP4418535B2 (ja) 2010-02-17
JP4843079B2 (ja) 2011-12-21
JP2006231090A (ja) 2006-09-07
WO1998008550A1 (en) 1998-03-05
EP0927053B1 (en) 2003-04-02
IL128496A0 (en) 2000-01-31
BR9711241A (pt) 1999-08-17
IL128496A (en) 2004-06-20
JP2009256391A (ja) 2009-11-05
CA2264647C (en) 2009-11-24
EP0927053A1 (en) 1999-07-07
RU2207882C2 (ru) 2003-07-10
AU4241297A (en) 1998-03-19
DE69720479T2 (de) 2004-03-04

Similar Documents

Publication Publication Date Title
BR9711241B8 (pt) processo para fabricar uma composição polimérica para prevenir ou inibir a formação de aderências de tecidos ou para inibir sangramento
CA2780294C (en) Polysaccharide based hydrogels
Corkhill et al. Synthetic hydrogels VI. Hydrogel composites as wound dressings and implant materials
US4871490A (en) Method of manufacturing hydrogel dressings
RU2273471C2 (ru) Гели, образованные при взаимодействии поливинилпирролидона с производными хитозана
US5166187A (en) Biomaterials with a base of mixtures of collagen, chitosan and glycosaminoglycans, process for preparing them and their application in human medicine
KR101918452B1 (ko) 카복시메틸키토산과 가교된 히알루론산 및 콜라겐을 포함하는 조성물 및, 그 제조방법
ES2383550T3 (es) Material sellante seco de acción rápida y métodos para su uso y elaboración
ATE252919T1 (de) Zusammensetzungen und ihre verwendung zur verhütung von verklebungen zwischen körpergewebe
CN107158452B (zh) 一种骨创面止血组合物及其制备方法和应用
US4828827A (en) Process for augmenting soft tissue with cross-linked polyvinyl pyrrolidone
RU99106523A (ru) Измельченные полимерные гидрогели для исключения образования спаек и способы их получения
WO2011057133A1 (en) Fragmented hydrogels
WO1994021299A1 (en) A composition and a method for tissue augmentation
US7976859B2 (en) Implant filling material and method
CN108525003A (zh) 基于酰腙键和亲疏水自组装的双交联杂化水凝胶、其制备方法及皮肤组织创面修复剂
US11246958B2 (en) Haemostatic compositions
US8084513B2 (en) Implant filling material and method
KR20040051130A (ko) 상처 치료용 수화겔의 제조방법
CN211068233U (zh) 一种成纤维细胞生长因子自粘性人工硬膜修补片
WO2023081677A1 (en) Synthetic surgical hemostat

Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFIRO O PEDIDO DE ACORDO COM O(S) ARTIGO(S) 37, 8O, 13 DA LPI 9.279

B12B Appeal against refusal [chapter 12.2 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07G Grant request does not fulfill article 229-c lpi (prior consent of anvisa) [chapter 7.7 patent gazette]

Free format text: NOTIFICACAO DE DEVOLUCAO DO PEDIDO POR NAO SE ENQUADRAR NO ART. 229-C DA LPI.

B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 20/12/2016, OBSERVADAS AS CONDICOES LEGAIS.

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 14/08/1997, OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF, QUE DETERMINA A ALTERACAO DO PRAZO DE CONCESSAO

B21A Patent or certificate of addition expired [chapter 21.1 patent gazette]

Free format text: PATENTE EXTINTA EM 15/08/2017