BRPI0518383A2 - partÍculas polimÉricas carregÁveis para aplicaÇÕes terepÊuticas e/ou diagnàstico e mÉtodos para preparar e usar as mesmas - Google Patents
partÍculas polimÉricas carregÁveis para aplicaÇÕes terepÊuticas e/ou diagnàstico e mÉtodos para preparar e usar as mesmasInfo
- Publication number
- BRPI0518383A2 BRPI0518383A2 BRPI0518383-9A BRPI0518383A BRPI0518383A2 BR PI0518383 A2 BRPI0518383 A2 BR PI0518383A2 BR PI0518383 A BRPI0518383 A BR PI0518383A BR PI0518383 A2 BRPI0518383 A2 BR PI0518383A2
- Authority
- BR
- Brazil
- Prior art keywords
- particles
- mammal
- core
- therapeutical
- preparing
- Prior art date
Links
- 239000002245 particle Substances 0.000 title abstract 13
- 230000001225 therapeutic effect Effects 0.000 title abstract 2
- 241000124008 Mammalia Species 0.000 abstract 3
- 239000013543 active substance Substances 0.000 abstract 2
- TZCXTZWJZNENPQ-UHFFFAOYSA-L barium sulfate Chemical compound [Ba+2].[O-]S([O-])(=O)=O TZCXTZWJZNENPQ-UHFFFAOYSA-L 0.000 abstract 2
- 239000011248 coating agent Substances 0.000 abstract 2
- 238000000576 coating method Methods 0.000 abstract 2
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 abstract 1
- 230000017531 blood circulation Effects 0.000 abstract 1
- 210000004204 blood vessel Anatomy 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 238000002405 diagnostic procedure Methods 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 239000000017 hydrogel Substances 0.000 abstract 1
- 238000002347 injection Methods 0.000 abstract 1
- 239000007924 injection Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- GKTNLYAAZKKMTQ-UHFFFAOYSA-N n-[bis(dimethylamino)phosphinimyl]-n-methylmethanamine Chemical compound CN(C)P(=N)(N(C)C)N(C)C GKTNLYAAZKKMTQ-UHFFFAOYSA-N 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
- 239000000700 radioactive tracer Substances 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
- 238000013268 sustained release Methods 0.000 abstract 1
- 239000012730 sustained-release form Substances 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
- 125000003652 trifluoroethoxy group Chemical group FC(CO*)(F)F 0.000 abstract 1
- 238000012285 ultrasound imaging Methods 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
- A61K49/0404—X-ray contrast preparations containing barium sulfate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
- A61K49/0409—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is not a halogenated organic compound
- A61K49/0414—Particles, beads, capsules or spheres
- A61K49/0419—Microparticles, microbeads, microcapsules, microspheres, i.e. having a size or diameter higher or equal to 1 micrometer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5089—Processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physics & Mathematics (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Hematology (AREA)
- Acoustics & Sound (AREA)
- Radiology & Medical Imaging (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
Abstract
PARTÍCULAS POLIMÉRICAS CARREGÁVEIS PARA APLICAÇÕES TERAPÊUTICAS E/OU DIAGNàSTICO E MÉTODOS PARA PREPARAR E USAR AS MESMAS. A presente invenção refere-se a partículas que são providas para uso em procedimentos terapêuticos e/ou de diagnóstico. As partículas incluem poli[bis(trifluoroetóxi) fosfazeno] e/ou um derivado do mesmo que pode estar presente por toda as partículas ou dentro de um revestimento externo das partículas. As partículas também podem incluir um núcleo tendo um hidrogel formado a partir de um polímero à base de acrílico. Sulfato de bário pode também ser provido ao núcleo das partículas como um revestimento ou absorvido dentro do núcleo das partículas. As partículas podem ser usadas para minimizar o fluxo sanguíneo dos tecidos dos mamíferos ocultando-se pelo menos uma porção de um vaso sanguíneo do mamífero ou para distribuir o agente ativo para uma área localizada dentro do corpo do mamífero contactando-se uma área localizada com pelo menos uma das partículas. Ainda, as partículas são úteis em formulações de liberação pro- longada incluindo agente (s) ativo (s) para administração oral, como partículas traçadas para injeção na corrente sanguínea de um mamífero ou para uso em formação de imagem de ultra-som aumentada. As partículas podem incluir agentes para aumentar a densidade para alcançar níveis de flutuação úteis na suspensão.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US62172904P | 2004-10-25 | 2004-10-25 | |
US68430705P | 2005-05-24 | 2005-05-24 | |
PCT/IB2005/004007 WO2006046155A2 (en) | 2004-10-25 | 2005-10-24 | Loadable polyphosphazene-comprising particles for therapeutic and/or diagnostic applications and methods of preparing and using the same |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0518383A2 true BRPI0518383A2 (pt) | 2008-11-18 |
Family
ID=36228155
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0518383-9A BRPI0518383A2 (pt) | 2004-10-25 | 2005-10-24 | partÍculas polimÉricas carregÁveis para aplicaÇÕes terepÊuticas e/ou diagnàstico e mÉtodos para preparar e usar as mesmas |
Country Status (14)
Country | Link |
---|---|
US (4) | US8318209B2 (pt) |
EP (1) | EP1804773B1 (pt) |
JP (1) | JP4885866B2 (pt) |
KR (1) | KR101153785B1 (pt) |
AT (1) | ATE503465T1 (pt) |
AU (1) | AU2005298344B2 (pt) |
BR (1) | BRPI0518383A2 (pt) |
CA (1) | CA2584122C (pt) |
DE (1) | DE602005027229D1 (pt) |
HK (1) | HK1116058A1 (pt) |
IL (1) | IL182650A (pt) |
MY (1) | MY147841A (pt) |
TW (1) | TW200626178A (pt) |
WO (1) | WO2006046155A2 (pt) |
Families Citing this family (68)
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EP3085362B1 (en) | 2005-05-09 | 2021-01-13 | Biosphere Medical, S.A. | Compositions and methods using microspheres and non-ionic contrast agents |
US8263109B2 (en) | 2005-05-09 | 2012-09-11 | Boston Scientific Scimed, Inc. | Injectable bulking compositions |
US20070003584A1 (en) | 2005-06-16 | 2007-01-04 | Russell Anderson | Liquid crystal polymer syringes and containers and methods of use for long term storage of filler materials |
WO2006138669A2 (en) | 2005-06-16 | 2006-12-28 | Artes Medical, Inc. | Life-like anatomic feature for testing injection of soft tissue fillers |
US20070100449A1 (en) | 2005-10-31 | 2007-05-03 | O'neil Michael | Injectable soft tissue fixation technique |
US8673019B2 (en) | 2006-04-13 | 2014-03-18 | Warsaw Orthopedic, Inc. | Use of anti-inflammatory compounds with allograft tissue implantation |
US20080058954A1 (en) | 2006-08-22 | 2008-03-06 | Hai Trieu | Methods of treating spinal injuries using injectable flowable compositions comprising organic materials |
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2005
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- 2005-10-24 AU AU2005298344A patent/AU2005298344B2/en active Active
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- 2005-10-24 JP JP2007537420A patent/JP4885866B2/ja active Active
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- 2005-10-24 WO PCT/IB2005/004007 patent/WO2006046155A2/en active Application Filing
- 2005-10-24 DE DE602005027229T patent/DE602005027229D1/de active Active
- 2005-10-24 BR BRPI0518383-9A patent/BRPI0518383A2/pt not_active Application Discontinuation
- 2005-10-24 CA CA2584122A patent/CA2584122C/en not_active Expired - Fee Related
- 2005-10-25 MY MYPI20055024A patent/MY147841A/en unknown
- 2005-10-25 US US11/257,535 patent/US8318209B2/en active Active
- 2005-10-25 TW TW094137269A patent/TW200626178A/zh unknown
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TW200626178A (en) | 2006-08-01 |
HK1116058A1 (en) | 2008-12-19 |
IL182650A (en) | 2013-01-31 |
US20210290555A1 (en) | 2021-09-23 |
DE602005027229D1 (de) | 2011-05-12 |
US11052050B2 (en) | 2021-07-06 |
JP4885866B2 (ja) | 2012-02-29 |
JP2008517899A (ja) | 2008-05-29 |
US20130052142A1 (en) | 2013-02-28 |
WO2006046155A3 (en) | 2006-08-17 |
KR20070084341A (ko) | 2007-08-24 |
AU2005298344A1 (en) | 2006-05-04 |
ATE503465T1 (de) | 2011-04-15 |
KR101153785B1 (ko) | 2012-07-09 |
WO2006046155A2 (en) | 2006-05-04 |
MY147841A (en) | 2013-01-31 |
CA2584122A1 (en) | 2006-05-04 |
US20060088476A1 (en) | 2006-04-27 |
US9511153B2 (en) | 2016-12-06 |
IL182650A0 (en) | 2007-07-24 |
EP1804773A2 (en) | 2007-07-11 |
CA2584122C (en) | 2013-04-30 |
US8318209B2 (en) | 2012-11-27 |
AU2005298344B2 (en) | 2011-02-10 |
US20170172933A1 (en) | 2017-06-22 |
EP1804773B1 (en) | 2011-03-30 |
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