MX9304868A - 27-hidroxirapamicina, derivados de la misma y composicion farmaceutica que la contiene. - Google Patents

27-hidroxirapamicina, derivados de la misma y composicion farmaceutica que la contiene.

Info

Publication number
MX9304868A
MX9304868A MX9304868A MX9304868A MX9304868A MX 9304868 A MX9304868 A MX 9304868A MX 9304868 A MX9304868 A MX 9304868A MX 9304868 A MX9304868 A MX 9304868A MX 9304868 A MX9304868 A MX 9304868A
Authority
MX
Mexico
Prior art keywords
hydroxyrapamicine
derived
same
pharmaceutical composition
hydroxyrapamycin
Prior art date
Application number
MX9304868A
Other languages
English (en)
Inventor
Frances Christy Nelson
Original Assignee
American Home Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/009,605 external-priority patent/US5256790A/en
Application filed by American Home Prod filed Critical American Home Prod
Publication of MX9304868A publication Critical patent/MX9304868A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Transplantation (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

La presente invención proporciona un compuesto de fórmula I, (ver fórmula); y derivados substituidos en la posición 27 del mismo, los cuales son útiles como agentes inmunosupresores, antiinflamatorios, antifúngicos, antitumor, y antiproliferativos. El compuesto representado por la fórmula I es llamado 27-hidroxirapamicina, y también puede ser aludido como 27-desoxo-27-hidroxitrapamicina.
MX9304868A 1992-08-13 1993-08-11 27-hidroxirapamicina, derivados de la misma y composicion farmaceutica que la contiene. MX9304868A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US93012492A 1992-08-13 1992-08-13
US08/009,605 US5256790A (en) 1992-08-13 1993-01-27 27-hydroxyrapamycin and derivatives thereof

Publications (1)

Publication Number Publication Date
MX9304868A true MX9304868A (es) 1994-05-31

Family

ID=26679675

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9304868A MX9304868A (es) 1992-08-13 1993-08-11 27-hidroxirapamicina, derivados de la misma y composicion farmaceutica que la contiene.

Country Status (12)

Country Link
EP (1) EP0655065B1 (es)
JP (1) JPH08501084A (es)
AT (1) ATE146179T1 (es)
AU (1) AU5007193A (es)
CA (1) CA2142288A1 (es)
DE (1) DE69306585T2 (es)
DK (1) DK0655065T3 (es)
ES (1) ES2096941T3 (es)
GR (1) GR3022730T3 (es)
HU (1) HU221499B (es)
MX (1) MX9304868A (es)
WO (1) WO1994004540A1 (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5527907A (en) * 1993-11-19 1996-06-18 Abbott Laboratories Macrolide immunomodulators
JP4105761B2 (ja) * 1993-11-19 2008-06-25 アボット・ラボラトリーズ ラパミシン（マクロライド）の半合成類似体免疫調節剤
US6187757B1 (en) 1995-06-07 2001-02-13 Ariad Pharmaceuticals, Inc. Regulation of biological events using novel compounds
CA2219659C (en) 1995-06-09 2008-03-18 Novartis Ag Rapamycin derivatives
US7067526B1 (en) 1999-08-24 2006-06-27 Ariad Gene Therapeutics, Inc. 28-epirapalogs
CA2383451A1 (en) 1999-08-24 2001-03-01 Ariad Gene Therapeutics, Inc. 28-epirapalogs
EA008379B1 (ru) 2002-02-01 2007-04-27 Ариад Джин Терапьютикс, Инк. Фосфорсодержащие соединения и их применения
ATE457716T1 (de) 2002-12-30 2010-03-15 Angiotech Int Ag Wirkstofffreisetzung von schnell gelierender polymerzusammensetzung
CA2571710A1 (en) 2004-06-24 2006-11-02 Nicholas Valiante Small molecule immunopotentiators and assays for their detection
CN103330694A (zh) 2006-11-14 2013-10-02 阿里亚德医药股份有限公司 口服制剂
WO2009089549A1 (en) 2008-01-11 2009-07-16 Massachusetts Eye & Ear Infirmary Conditional-stop dimerizable caspase transgenic animals
CN105283553B (zh) 2013-06-11 2021-06-25 克隆技术实验室有限公司 蛋白质富集的微泡及其制备和使用方法
JP7381492B2 (ja) 2018-05-01 2023-11-15 レヴォリューション・メディスンズ，インコーポレイテッド Ｍｔｏｒ阻害剤としてのｃ２６－連結ラパマイシン類似体
AU2019262978B2 (en) 2018-05-01 2023-07-13 Revolution Medicines, Inc. C40-, C28-, and C-32-linked rapamycin analogs as mTOR inhibitors
IL307600A (en) * 2021-04-09 2023-12-01 Revolution Medicines Inc Synthesis of rapamycin analog compounds

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04230389A (ja) * 1990-07-16 1992-08-19 American Home Prod Corp ラパマイシン誘導体
US5102876A (en) * 1991-05-07 1992-04-07 American Home Products Corporation Reduction products of rapamycin

Also Published As

Publication number Publication date
AU5007193A (en) 1994-03-15
EP0655065B1 (en) 1996-12-11
ATE146179T1 (de) 1996-12-15
ES2096941T3 (es) 1997-03-16
GR3022730T3 (en) 1997-06-30
HU221499B (en) 2002-10-28
HUT71614A (en) 1996-01-29
CA2142288A1 (en) 1994-03-03
HU9500432D0 (en) 1995-04-28
DE69306585T2 (de) 1997-04-17
JPH08501084A (ja) 1996-02-06
WO1994004540A1 (en) 1994-03-03
EP0655065A1 (en) 1995-05-31
DE69306585D1 (de) 1997-01-23
DK0655065T3 (es) 1997-02-24

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Legal Events

Date Code Title Description
FG Grant or registration
HC Change of company name or juridical status

Owner name: SILGAN TUBES CORPORATION

MM Annulment or lapse due to non-payment of fees