ATE146179T1 - 27 hydroxyrapamycin und derivate davon - Google Patents

27 hydroxyrapamycin und derivate davon

Info

Publication number
ATE146179T1
ATE146179T1 AT93919994T AT93919994T ATE146179T1 AT E146179 T1 ATE146179 T1 AT E146179T1 AT 93919994 T AT93919994 T AT 93919994T AT 93919994 T AT93919994 T AT 93919994T AT E146179 T1 ATE146179 T1 AT E146179T1
Authority
AT
Austria
Prior art keywords
hydroxyrapamycin
derivatives
formula
compound
deoxo
Prior art date
Application number
AT93919994T
Other languages
English (en)
Inventor
Frances Christy Nelson
Original Assignee
American Home Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/009,605 external-priority patent/US5256790A/en
Application filed by American Home Prod filed Critical American Home Prod
Application granted granted Critical
Publication of ATE146179T1 publication Critical patent/ATE146179T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Transplantation (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AT93919994T 1992-08-13 1993-08-12 27 hydroxyrapamycin und derivate davon ATE146179T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US93012492A 1992-08-13 1992-08-13
US08/009,605 US5256790A (en) 1992-08-13 1993-01-27 27-hydroxyrapamycin and derivatives thereof

Publications (1)

Publication Number Publication Date
ATE146179T1 true ATE146179T1 (de) 1996-12-15

Family

ID=26679675

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93919994T ATE146179T1 (de) 1992-08-13 1993-08-12 27 hydroxyrapamycin und derivate davon

Country Status (12)

Country Link
EP (1) EP0655065B1 (de)
JP (1) JPH08501084A (de)
AT (1) ATE146179T1 (de)
AU (1) AU5007193A (de)
CA (1) CA2142288A1 (de)
DE (1) DE69306585T2 (de)
DK (1) DK0655065T3 (de)
ES (1) ES2096941T3 (de)
GR (1) GR3022730T3 (de)
HU (1) HU221499B (de)
MX (1) MX9304868A (de)
WO (1) WO1994004540A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995014023A1 (en) * 1993-11-19 1995-05-26 Abbott Laboratories Semisynthetic analogs of rapamycin (macrolides) being immunomodulators
US5527907A (en) * 1993-11-19 1996-06-18 Abbott Laboratories Macrolide immunomodulators
US6187757B1 (en) 1995-06-07 2001-02-13 Ariad Pharmaceuticals, Inc. Regulation of biological events using novel compounds
US5985890A (en) * 1995-06-09 1999-11-16 Novartis Ag Rapamycin derivatives
US7067526B1 (en) 1999-08-24 2006-06-27 Ariad Gene Therapeutics, Inc. 28-epirapalogs
ES2219388T3 (es) 1999-08-24 2004-12-01 Ariad Gene Therapeutics, Inc. 28-epi-rapalogos.
MXPA04007402A (es) 2002-02-01 2005-06-17 Ariad Gene Therapeutics Inc Compuestos que contienen fosforo y usos de los mismos.
ATE457716T1 (de) 2002-12-30 2010-03-15 Angiotech Int Ag Wirkstofffreisetzung von schnell gelierender polymerzusammensetzung
US20110104186A1 (en) 2004-06-24 2011-05-05 Nicholas Valiante Small molecule immunopotentiators and assays for their detection
CN101583347A (zh) 2006-11-14 2009-11-18 阿里亚德医药股份有限公司 口服制剂
CA2711765A1 (en) 2008-01-11 2009-07-16 Massachusetts Eye & Ear Infirmary Conditional-stop dimerizable caspase transgenic animals
CA2905229C (en) 2013-06-11 2023-10-10 Clontech Laboratories, Inc. Protein enriched microvesicles and methods of making and using the same
CR20200578A (es) 2018-05-01 2021-02-22 Revolution Medicines Inc Análogos de rapamicina a c40, c28 y c32 como inhibidores de mtor
IL312291A (en) 2018-05-01 2024-06-01 Revolution Medicines Inc C-26-linked rapamycin analogs as MTOR inhibitors
IL307600A (en) * 2021-04-09 2023-12-01 Revolution Medicines Inc Synthesis of rapamycin analog compounds

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04230389A (ja) * 1990-07-16 1992-08-19 American Home Prod Corp ラパマイシン誘導体
US5102876A (en) * 1991-05-07 1992-04-07 American Home Products Corporation Reduction products of rapamycin

Also Published As

Publication number Publication date
HU9500432D0 (en) 1995-04-28
WO1994004540A1 (en) 1994-03-03
DK0655065T3 (de) 1997-02-24
JPH08501084A (ja) 1996-02-06
EP0655065A1 (de) 1995-05-31
HUT71614A (en) 1996-01-29
HU221499B (en) 2002-10-28
AU5007193A (en) 1994-03-15
ES2096941T3 (es) 1997-03-16
GR3022730T3 (en) 1997-06-30
MX9304868A (es) 1994-05-31
CA2142288A1 (en) 1994-03-03
EP0655065B1 (de) 1996-12-11
DE69306585T2 (de) 1997-04-17
DE69306585D1 (de) 1997-01-23

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee