GR3022730T3 - 27-hydroxyrapamycin and derivatives thereof. - Google Patents

27-hydroxyrapamycin and derivatives thereof.

Info

Publication number
GR3022730T3
GR3022730T3 GR970400422T GR970400422T GR3022730T3 GR 3022730 T3 GR3022730 T3 GR 3022730T3 GR 970400422 T GR970400422 T GR 970400422T GR 970400422 T GR970400422 T GR 970400422T GR 3022730 T3 GR3022730 T3 GR 3022730T3
Authority
GR
Greece
Prior art keywords
hydroxyrapamycin
derivatives
formula
compound
deoxo
Prior art date
Application number
GR970400422T
Other languages
English (en)
Inventor
Frances Christy Nelson
Original Assignee
American Home Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/009,605 external-priority patent/US5256790A/en
Application filed by American Home Prod filed Critical American Home Prod
Publication of GR3022730T3 publication Critical patent/GR3022730T3/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Transplantation (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
GR970400422T 1992-08-13 1997-03-03 27-hydroxyrapamycin and derivatives thereof. GR3022730T3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US93012492A 1992-08-13 1992-08-13
US08/009,605 US5256790A (en) 1992-08-13 1993-01-27 27-hydroxyrapamycin and derivatives thereof
PCT/US1993/007581 WO1994004540A1 (en) 1992-08-13 1993-08-12 27-hydroxyrapamycin and derivatives thereof

Publications (1)

Publication Number Publication Date
GR3022730T3 true GR3022730T3 (en) 1997-06-30

Family

ID=26679675

Family Applications (1)

Application Number Title Priority Date Filing Date
GR970400422T GR3022730T3 (en) 1992-08-13 1997-03-03 27-hydroxyrapamycin and derivatives thereof.

Country Status (12)

Country Link
EP (1) EP0655065B1 (el)
JP (1) JPH08501084A (el)
AT (1) ATE146179T1 (el)
AU (1) AU5007193A (el)
CA (1) CA2142288A1 (el)
DE (1) DE69306585T2 (el)
DK (1) DK0655065T3 (el)
ES (1) ES2096941T3 (el)
GR (1) GR3022730T3 (el)
HU (1) HU221499B (el)
MX (1) MX9304868A (el)
WO (1) WO1994004540A1 (el)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2175215C (en) * 1993-11-19 2008-06-03 Yat Sun Or Semisynthetic analogs of rapamycin (macrolides) being immunomodulators
US5527907A (en) * 1993-11-19 1996-06-18 Abbott Laboratories Macrolide immunomodulators
US6187757B1 (en) 1995-06-07 2001-02-13 Ariad Pharmaceuticals, Inc. Regulation of biological events using novel compounds
PT833828E (pt) * 1995-06-09 2003-02-28 Novartis Ag Derivados de rapamicina
EP1212331B1 (en) 1999-08-24 2004-04-21 Ariad Gene Therapeutics, Inc. 28-epirapalogs
US7067526B1 (en) 1999-08-24 2006-06-27 Ariad Gene Therapeutics, Inc. 28-epirapalogs
ES2485841T3 (es) 2002-02-01 2014-08-14 Ariad Pharmaceuticals, Inc Compuestos que contienen fósforo y usos de los mismos
EP2181704B1 (en) 2002-12-30 2015-05-06 Angiotech International Ag Drug delivery from rapid gelling polymer composition
CA2571710A1 (en) 2004-06-24 2006-11-02 Nicholas Valiante Small molecule immunopotentiators and assays for their detection
JP2010509400A (ja) 2006-11-14 2010-03-25 アリアド・ファーマシューティカルズ・インコーポレイテッド 経口処方組成物
US8921642B2 (en) 2008-01-11 2014-12-30 Massachusetts Eye And Ear Infirmary Conditional-stop dimerizable caspase transgenic animals
CN105283553B (zh) 2013-06-11 2021-06-25 克隆技术实验室有限公司 蛋白质富集的微泡及其制备和使用方法
JP7381492B2 (ja) 2018-05-01 2023-11-15 レヴォリューション・メディスンズ，インコーポレイテッド Ｍｔｏｒ阻害剤としてのｃ２６－連結ラパマイシン類似体
BR112020022201A2 (pt) 2018-05-01 2021-02-02 Revolution Medicines, Inc. análogos de rapamicina ligada a c40, c28, e c-32 como inibidores de mtor
CN117412954A (zh) * 2021-04-09 2024-01-16 锐新医药公司 雷帕霉素类似物化合物的合成
TW202402277A (zh) 2022-05-25 2024-01-16 美商銳新醫藥公司 以mtor抑制劑治療癌症之方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04230389A (ja) * 1990-07-16 1992-08-19 American Home Prod Corp ラパマイシン誘導体
US5102876A (en) * 1991-05-07 1992-04-07 American Home Products Corporation Reduction products of rapamycin

Also Published As

Publication number Publication date
ES2096941T3 (es) 1997-03-16
HU9500432D0 (en) 1995-04-28
DK0655065T3 (el) 1997-02-24
HUT71614A (en) 1996-01-29
MX9304868A (es) 1994-05-31
HU221499B (en) 2002-10-28
WO1994004540A1 (en) 1994-03-03
JPH08501084A (ja) 1996-02-06
EP0655065A1 (en) 1995-05-31
ATE146179T1 (de) 1996-12-15
CA2142288A1 (en) 1994-03-03
EP0655065B1 (en) 1996-12-11
DE69306585T2 (de) 1997-04-17
DE69306585D1 (de) 1997-01-23
AU5007193A (en) 1994-03-15

Similar Documents

Publication Publication Date Title
DK0655065T3 (el)
ES2085726T3 (es) Derivado prolinico de rapamicina, su produccion y aplicacion.
GR3035835T3 (en) Heterocyclic esters of rapamycin and pharmaceutical compositions containing them
NZ297661A (en) Hindered N-oxide esters of rapamycin and pharmaceutical compositions
ES2069137T3 (es) Derivados de imidazopiridina y su uso.
IL96882A0 (en) Uracil derivatives and pesticides containing the same as active ingredient
TW360678B (en) Synergistic stabilizer mixture for polyolefins
EP0630898A4 (en) MEDICINE FOR THROMBOZYTOPENIA.
CA2074533A1 (en) 2-nitroimidazole derivative, production thereof, and radiosensitizer containing the same as active ingredient
NO974890D0 (no) Radicicolderivater
MY107303A (en) N-phenylpyrazole derivatives as insecticides.
TW223637B (el)
JO1704B1 (en) New potent compounds
AU2623192A (en) Antifungal agent
GB9325618D0 (en) New herbicides
AP9400632A0 (en) Ether derivatives.
CA2111955A1 (en) Novel tetracyclic compound
AU621996B2 (en) 2,5,6,7-tetranor-4,8-inter-m-phenylene pgi2 derivatives
UY24327A1 (es) Derivados de cefalosporina
MY115430A (en) Glutaramide derivatives.
AU1446892A (en) Novel oxa- or azasteroid derivative
AU7020996A (en) UCK14 compounds
AP9400608A0 (en) "New nicotinic acid derivative".
CA2032311A1 (en) 2,19-methyleneoxy and 2,19-methylenethio bridged steroids as aromatase and 19-hydroxylase inhibitors
DK0565059T3 (da) Indolderivat