DK0655065T3 - - Google Patents

Info

Publication number
DK0655065T3
DK0655065T3 DK93919994.9T DK93919994T DK0655065T3 DK 0655065 T3 DK0655065 T3 DK 0655065T3 DK 93919994 T DK93919994 T DK 93919994T DK 0655065 T3 DK0655065 T3 DK 0655065T3
Authority
DK
Denmark
Prior art keywords
hydroxyrapamycin
formula
compound
deoxo
immunosuppressive
Prior art date
Application number
DK93919994.9T
Other languages
Danish (da)
English (en)
Inventor
Frances Christy Nelson
Original Assignee
American Home Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/009,605 external-priority patent/US5256790A/en
Application filed by American Home Prod filed Critical American Home Prod
Application granted granted Critical
Publication of DK0655065T3 publication Critical patent/DK0655065T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Transplantation (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DK93919994.9T 1992-08-13 1993-08-12 DK0655065T3 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US93012492A 1992-08-13 1992-08-13
US08/009,605 US5256790A (en) 1992-08-13 1993-01-27 27-hydroxyrapamycin and derivatives thereof

Publications (1)

Publication Number Publication Date
DK0655065T3 true DK0655065T3 (el) 1997-02-24

Family

ID=26679675

Family Applications (1)

Application Number Title Priority Date Filing Date
DK93919994.9T DK0655065T3 (el) 1992-08-13 1993-08-12

Country Status (12)

Country Link
EP (1) EP0655065B1 (el)
JP (1) JPH08501084A (el)
AT (1) ATE146179T1 (el)
AU (1) AU5007193A (el)
CA (1) CA2142288A1 (el)
DE (1) DE69306585T2 (el)
DK (1) DK0655065T3 (el)
ES (1) ES2096941T3 (el)
GR (1) GR3022730T3 (el)
HU (1) HU221499B (el)
MX (1) MX9304868A (el)
WO (1) WO1994004540A1 (el)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2175215C (en) * 1993-11-19 2008-06-03 Yat Sun Or Semisynthetic analogs of rapamycin (macrolides) being immunomodulators
US5527907A (en) * 1993-11-19 1996-06-18 Abbott Laboratories Macrolide immunomodulators
US6187757B1 (en) 1995-06-07 2001-02-13 Ariad Pharmaceuticals, Inc. Regulation of biological events using novel compounds
WO1996041807A1 (en) * 1995-06-09 1996-12-27 Novartis Ag Rapamycin derivatives
US7067526B1 (en) 1999-08-24 2006-06-27 Ariad Gene Therapeutics, Inc. 28-epirapalogs
AU783158B2 (en) 1999-08-24 2005-09-29 Ariad Pharmaceuticals, Inc. 28-epirapalogs
KR100956195B1 (ko) * 2002-02-01 2010-05-06 어리어드 파마슈티칼스, 인코포레이티드 인 함유 화합물 및 이의 용도
WO2004060346A2 (en) 2002-12-30 2004-07-22 Angiotech International Ag Drug delivery from rapid gelling polymer composition
US20110104186A1 (en) 2004-06-24 2011-05-05 Nicholas Valiante Small molecule immunopotentiators and assays for their detection
EP2094241A4 (en) 2006-11-14 2013-04-17 Ariad Pharma Inc ORAL FORMULATIONS
US8921642B2 (en) 2008-01-11 2014-12-30 Massachusetts Eye And Ear Infirmary Conditional-stop dimerizable caspase transgenic animals
IL312291A (en) 2018-05-01 2024-06-01 Revolution Medicines Inc C-26-linked rapamycin analogs as MTOR inhibitors
LT3788049T (lt) 2018-05-01 2023-07-25 Revolution Medicines, Inc. Rapamicino analogai, sujungti su c40-, c28- ir c32-, kaip mtor inhibitoriai
BR112023020658A2 (pt) * 2021-04-09 2023-12-05 Revolution Medicines Inc Síntese de compostos análogos à rapamicina

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04230389A (ja) * 1990-07-16 1992-08-19 American Home Prod Corp ラパマイシン誘導体
US5102876A (en) * 1991-05-07 1992-04-07 American Home Products Corporation Reduction products of rapamycin

Also Published As

Publication number Publication date
DE69306585T2 (de) 1997-04-17
HUT71614A (en) 1996-01-29
JPH08501084A (ja) 1996-02-06
ATE146179T1 (de) 1996-12-15
EP0655065A1 (en) 1995-05-31
GR3022730T3 (en) 1997-06-30
HU9500432D0 (en) 1995-04-28
CA2142288A1 (en) 1994-03-03
WO1994004540A1 (en) 1994-03-03
AU5007193A (en) 1994-03-15
HU221499B (en) 2002-10-28
MX9304868A (es) 1994-05-31
ES2096941T3 (es) 1997-03-16
DE69306585D1 (de) 1997-01-23
EP0655065B1 (en) 1996-12-11

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