DK0655065T3 - - Google Patents
Info
- Publication number
- DK0655065T3 DK0655065T3 DK93919994.9T DK93919994T DK0655065T3 DK 0655065 T3 DK0655065 T3 DK 0655065T3 DK 93919994 T DK93919994 T DK 93919994T DK 0655065 T3 DK0655065 T3 DK 0655065T3
- Authority
- DK
- Denmark
- Prior art keywords
- hydroxyrapamycin
- formula
- compound
- deoxo
- immunosuppressive
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Transplantation (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US93012492A | 1992-08-13 | 1992-08-13 | |
US08/009,605 US5256790A (en) | 1992-08-13 | 1993-01-27 | 27-hydroxyrapamycin and derivatives thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0655065T3 true DK0655065T3 (da) | 1997-02-24 |
Family
ID=26679675
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK93919994.9T DK0655065T3 (da) | 1992-08-13 | 1993-08-12 |
Country Status (12)
Country | Link |
---|---|
EP (1) | EP0655065B1 (da) |
JP (1) | JPH08501084A (da) |
AT (1) | ATE146179T1 (da) |
AU (1) | AU5007193A (da) |
CA (1) | CA2142288A1 (da) |
DE (1) | DE69306585T2 (da) |
DK (1) | DK0655065T3 (da) |
ES (1) | ES2096941T3 (da) |
GR (1) | GR3022730T3 (da) |
HU (1) | HU221499B (da) |
MX (1) | MX9304868A (da) |
WO (1) | WO1994004540A1 (da) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5527907A (en) * | 1993-11-19 | 1996-06-18 | Abbott Laboratories | Macrolide immunomodulators |
CA2175215C (en) * | 1993-11-19 | 2008-06-03 | Yat Sun Or | Semisynthetic analogs of rapamycin (macrolides) being immunomodulators |
US6187757B1 (en) | 1995-06-07 | 2001-02-13 | Ariad Pharmaceuticals, Inc. | Regulation of biological events using novel compounds |
PT833828E (pt) | 1995-06-09 | 2003-02-28 | Novartis Ag | Derivados de rapamicina |
US7067526B1 (en) | 1999-08-24 | 2006-06-27 | Ariad Gene Therapeutics, Inc. | 28-epirapalogs |
WO2001014387A1 (en) | 1999-08-24 | 2001-03-01 | Ariad Gene Therapeutics, Inc. | 28-epirapalogs |
EA008379B1 (ru) * | 2002-02-01 | 2007-04-27 | Ариад Джин Терапьютикс, Инк. | Фосфорсодержащие соединения и их применения |
CA2511521C (en) | 2002-12-30 | 2012-02-07 | Angiotech International Ag | Drug delivery from rapid gelling polymer composition |
CA2571710A1 (en) | 2004-06-24 | 2006-11-02 | Nicholas Valiante | Small molecule immunopotentiators and assays for their detection |
CA2669415A1 (en) | 2006-11-14 | 2008-05-22 | Ariad Pharmaceuticals, Inc. | Solid dosage form comprising ap23573 |
US8921642B2 (en) | 2008-01-11 | 2014-12-30 | Massachusetts Eye And Ear Infirmary | Conditional-stop dimerizable caspase transgenic animals |
US9593356B2 (en) | 2013-06-11 | 2017-03-14 | Takara Bio Usa, Inc. | Protein enriched microvesicles and methods of making and using the same |
HUE062352T2 (hu) | 2018-05-01 | 2023-10-28 | Revolution Medicines Inc | C40-, C28- és C-32-helyzetekben kapcsolt rapamycin-analógok mint mTOR-inhibitorok |
IL278335B1 (en) | 2018-05-01 | 2024-05-01 | Revolution Medicines Inc | C26-linked rapamycin analogs as MTOR inhibitors |
KR20240006537A (ko) * | 2021-04-09 | 2024-01-15 | 레볼루션 메디슨즈, 인크. | 라파마이신 유사체 화합물의 합성 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH04230389A (ja) * | 1990-07-16 | 1992-08-19 | American Home Prod Corp | ラパマイシン誘導体 |
US5102876A (en) * | 1991-05-07 | 1992-04-07 | American Home Products Corporation | Reduction products of rapamycin |
-
1993
- 1993-08-11 MX MX9304868A patent/MX9304868A/es not_active IP Right Cessation
- 1993-08-12 JP JP6506398A patent/JPH08501084A/ja active Pending
- 1993-08-12 CA CA002142288A patent/CA2142288A1/en not_active Abandoned
- 1993-08-12 DE DE69306585T patent/DE69306585T2/de not_active Expired - Fee Related
- 1993-08-12 EP EP93919994A patent/EP0655065B1/en not_active Expired - Lifetime
- 1993-08-12 WO PCT/US1993/007581 patent/WO1994004540A1/en active IP Right Grant
- 1993-08-12 AU AU50071/93A patent/AU5007193A/en not_active Abandoned
- 1993-08-12 AT AT93919994T patent/ATE146179T1/de not_active IP Right Cessation
- 1993-08-12 ES ES93919994T patent/ES2096941T3/es not_active Expired - Lifetime
- 1993-08-12 DK DK93919994.9T patent/DK0655065T3/da active
- 1993-08-12 HU HU9500432A patent/HU221499B/hu not_active IP Right Cessation
-
1997
- 1997-03-03 GR GR970400422T patent/GR3022730T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
EP0655065A1 (en) | 1995-05-31 |
EP0655065B1 (en) | 1996-12-11 |
DE69306585D1 (de) | 1997-01-23 |
HUT71614A (en) | 1996-01-29 |
GR3022730T3 (en) | 1997-06-30 |
ATE146179T1 (de) | 1996-12-15 |
DE69306585T2 (de) | 1997-04-17 |
WO1994004540A1 (en) | 1994-03-03 |
CA2142288A1 (en) | 1994-03-03 |
JPH08501084A (ja) | 1996-02-06 |
HU9500432D0 (en) | 1995-04-28 |
AU5007193A (en) | 1994-03-15 |
ES2096941T3 (es) | 1997-03-16 |
HU221499B (en) | 2002-10-28 |
MX9304868A (es) | 1994-05-31 |
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