DK0655065T3 - - Google Patents

Info

Publication number
DK0655065T3
DK0655065T3 DK93919994.9T DK93919994T DK0655065T3 DK 0655065 T3 DK0655065 T3 DK 0655065T3 DK 93919994 T DK93919994 T DK 93919994T DK 0655065 T3 DK0655065 T3 DK 0655065T3
Authority
DK
Denmark
Prior art keywords
hydroxyrapamycin
formula
compound
deoxo
immunosuppressive
Prior art date
Application number
DK93919994.9T
Other languages
English (en)
Inventor
Frances Christy Nelson
Original Assignee
American Home Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/009,605 external-priority patent/US5256790A/en
Application filed by American Home Prod filed Critical American Home Prod
Application granted granted Critical
Publication of DK0655065T3 publication Critical patent/DK0655065T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Transplantation (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DK93919994.9T 1992-08-13 1993-08-12 DK0655065T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US93012492A 1992-08-13 1992-08-13
US08/009,605 US5256790A (en) 1992-08-13 1993-01-27 27-hydroxyrapamycin and derivatives thereof

Publications (1)

Publication Number Publication Date
DK0655065T3 true DK0655065T3 (da) 1997-02-24

Family

ID=26679675

Family Applications (1)

Application Number Title Priority Date Filing Date
DK93919994.9T DK0655065T3 (da) 1992-08-13 1993-08-12

Country Status (12)

Country Link
EP (1) EP0655065B1 (da)
JP (1) JPH08501084A (da)
AT (1) ATE146179T1 (da)
AU (1) AU5007193A (da)
CA (1) CA2142288A1 (da)
DE (1) DE69306585T2 (da)
DK (1) DK0655065T3 (da)
ES (1) ES2096941T3 (da)
GR (1) GR3022730T3 (da)
HU (1) HU221499B (da)
MX (1) MX9304868A (da)
WO (1) WO1994004540A1 (da)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5527907A (en) * 1993-11-19 1996-06-18 Abbott Laboratories Macrolide immunomodulators
CA2175215C (en) * 1993-11-19 2008-06-03 Yat Sun Or Semisynthetic analogs of rapamycin (macrolides) being immunomodulators
US6187757B1 (en) 1995-06-07 2001-02-13 Ariad Pharmaceuticals, Inc. Regulation of biological events using novel compounds
PT833828E (pt) 1995-06-09 2003-02-28 Novartis Ag Derivados de rapamicina
US7067526B1 (en) 1999-08-24 2006-06-27 Ariad Gene Therapeutics, Inc. 28-epirapalogs
WO2001014387A1 (en) 1999-08-24 2001-03-01 Ariad Gene Therapeutics, Inc. 28-epirapalogs
EA008379B1 (ru) * 2002-02-01 2007-04-27 Ариад Джин Терапьютикс, Инк. Фосфорсодержащие соединения и их применения
CA2511521C (en) 2002-12-30 2012-02-07 Angiotech International Ag Drug delivery from rapid gelling polymer composition
CA2571710A1 (en) 2004-06-24 2006-11-02 Nicholas Valiante Small molecule immunopotentiators and assays for their detection
CA2669415A1 (en) 2006-11-14 2008-05-22 Ariad Pharmaceuticals, Inc. Solid dosage form comprising ap23573
US8921642B2 (en) 2008-01-11 2014-12-30 Massachusetts Eye And Ear Infirmary Conditional-stop dimerizable caspase transgenic animals
US9593356B2 (en) 2013-06-11 2017-03-14 Takara Bio Usa, Inc. Protein enriched microvesicles and methods of making and using the same
HUE062352T2 (hu) 2018-05-01 2023-10-28 Revolution Medicines Inc C40-, C28- és C-32-helyzetekben kapcsolt rapamycin-analógok mint mTOR-inhibitorok
IL278335B1 (en) 2018-05-01 2024-05-01 Revolution Medicines Inc C26-linked rapamycin analogs as MTOR inhibitors
KR20240006537A (ko) * 2021-04-09 2024-01-15 레볼루션 메디슨즈, 인크. 라파마이신 유사체 화합물의 합성

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04230389A (ja) * 1990-07-16 1992-08-19 American Home Prod Corp ラパマイシン誘導体
US5102876A (en) * 1991-05-07 1992-04-07 American Home Products Corporation Reduction products of rapamycin

Also Published As

Publication number Publication date
EP0655065A1 (en) 1995-05-31
EP0655065B1 (en) 1996-12-11
DE69306585D1 (de) 1997-01-23
HUT71614A (en) 1996-01-29
GR3022730T3 (en) 1997-06-30
ATE146179T1 (de) 1996-12-15
DE69306585T2 (de) 1997-04-17
WO1994004540A1 (en) 1994-03-03
CA2142288A1 (en) 1994-03-03
JPH08501084A (ja) 1996-02-06
HU9500432D0 (en) 1995-04-28
AU5007193A (en) 1994-03-15
ES2096941T3 (es) 1997-03-16
HU221499B (en) 2002-10-28
MX9304868A (es) 1994-05-31

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