RU94036749A - Замещенные 1-нафтилпиразол-3-карбоксамиды, способ их получения, содержащие их фармацевтические композиции и промежуточные соединения синтеза - Google Patents

Замещенные 1-нафтилпиразол-3-карбоксамиды, способ их получения, содержащие их фармацевтические композиции и промежуточные соединения синтеза

Info

Publication number
RU94036749A
RU94036749A RU94036749/04A RU94036749A RU94036749A RU 94036749 A RU94036749 A RU 94036749A RU 94036749/04 A RU94036749/04 A RU 94036749/04A RU 94036749 A RU94036749 A RU 94036749A RU 94036749 A RU94036749 A RU 94036749A
Authority
RU
Russia
Prior art keywords
synthesis
naphthylpyrazole
carboxamides
substituted
pharmaceutical compositions
Prior art date
Application number
RU94036749/04A
Other languages
English (en)
Other versions
RU2140912C1 (ru
Inventor
Лабеэв Бернар
Fr]
Гюли Даниелл
Жанжан Франсис
Молимар Жан-Шарль
Буажгрэн Робер
Original Assignee
Санофи (FR)
Санофи
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Санофи (FR), Санофи filed Critical Санофи (FR)
Publication of RU94036749A publication Critical patent/RU94036749A/ru
Application granted granted Critical
Publication of RU2140912C1 publication Critical patent/RU2140912C1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C07C243/10—Hydrazines
    • C07C243/22—Hydrazines having nitrogen atoms of hydrazine groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/63—Carboxylic acid nitriles containing cyano groups and nitrogen atoms further bound to other hetero atoms, other than oxygen atoms of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C255/65—Carboxylic acid nitriles containing cyano groups and nitrogen atoms further bound to other hetero atoms, other than oxygen atoms of nitro or nitroso groups, bound to the same carbon skeleton with the nitrogen atoms further bound to nitrogen atoms
    • C07C255/66—Carboxylic acid nitriles containing cyano groups and nitrogen atoms further bound to other hetero atoms, other than oxygen atoms of nitro or nitroso groups, bound to the same carbon skeleton with the nitrogen atoms further bound to nitrogen atoms having cyano groups and nitrogen atoms being part of hydrazine or hydrazone groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Предметом изобретения являются новые производные 1-нафтилпиразол-3-карбоксамидов, которые могут найти применение в качестве агентов для лечения нейропсихиатрических расстройств, в особенности таких, которые связаны с дисфукционированием допаминергических систем. Изобретение относится также к способу получения новых производных.

Claims (1)

  1. Предметом изобретения являются новые производные 1-нафтилпиразол-3-карбоксамидов, которые могут найти применение в качестве агентов для лечения нейропсихиатрических расстройств, в особенности таких, которые связаны с дисфукционированием допаминергических систем. Изобретение относится также к способу получения новых производных.
    Figure 00000001
RU94036749A 1993-10-12 1994-10-11 Замещенные 1-нафтилпиразол-3-карбоксамиды, способ их получения, содержащая их фармацевтическая композиция и промежуточные соединения синтеза RU2140912C1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9312136A FR2711140B1 (fr) 1993-10-12 1993-10-12 1-Naphtylpyrazole-3-carboxamides substitués actifs sur la neurotensine, leur préparation, les compositions pharmaceutiques en contenant.
FR9312136 1993-10-12

Publications (2)

Publication Number Publication Date
RU94036749A true RU94036749A (ru) 1996-10-10
RU2140912C1 RU2140912C1 (ru) 1999-11-10

Family

ID=9451754

Family Applications (1)

Application Number Title Priority Date Filing Date
RU94036749A RU2140912C1 (ru) 1993-10-12 1994-10-11 Замещенные 1-нафтилпиразол-3-карбоксамиды, способ их получения, содержащая их фармацевтическая композиция и промежуточные соединения синтеза

Country Status (18)

Country Link
US (3) US5502059A (ru)
EP (1) EP0647629B1 (ru)
JP (1) JPH07278114A (ru)
KR (1) KR950011413A (ru)
CN (1) CN1108651A (ru)
AT (1) ATE181911T1 (ru)
AU (1) AU685154B2 (ru)
CA (1) CA2117821A1 (ru)
DE (1) DE69419377D1 (ru)
FI (1) FI944770A (ru)
FR (1) FR2711140B1 (ru)
HU (1) HUT70048A (ru)
IL (1) IL111239A0 (ru)
NO (1) NO304595B1 (ru)
NZ (1) NZ264661A (ru)
RU (1) RU2140912C1 (ru)
TW (1) TW300890B (ru)
ZA (1) ZA947957B (ru)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6716991B1 (en) 1993-11-30 2004-04-06 G. D. Searle & Co. Process for preparing a substituted pyrazolyl benzenesulfonamide for the treatment of inflammation
US6492411B1 (en) 1993-11-30 2002-12-10 G. D. Searle & Co. Substituted pyrazolyl benzenesulfonamides for the treatment of inflammation
FR2732967B1 (fr) * 1995-04-11 1997-07-04 Sanofi Sa 1-phenylpyrazole-3-carboxamides substitues, actifs sur la neurotensine, leur preparation, les compositions pharmaceutiques en contenant
FR2741621B1 (fr) * 1995-11-23 1998-02-13 Sanofi Sa Nouveaux derives de pyrazole, procede pour leur preparation et compositions pharmaceutiques en contenant
US6521561B1 (en) 1998-05-01 2003-02-18 President And Fellows Of Harvard College Main-group metal based asymmetric catalysts and applications thereof
IL142707A0 (en) 2000-04-27 2002-03-10 Pfizer Prod Inc Methods of treating obesity using a neurotensin receptor ligand
KR100425881B1 (ko) * 2001-03-14 2004-04-03 고광호 신규한 몰피난 유도체
WO2002092695A1 (fr) * 2001-05-11 2002-11-21 Mitsui Chemicals, Inc. Agent dopant et materiau polymere electroconducteur comprenant cet agent dopant
ATE286023T1 (de) * 2001-07-11 2005-01-15 Boehringer Ingelheim Pharma Neue synthese für heteroarylamin-verbindungen
US6603000B2 (en) 2001-07-11 2003-08-05 Boehringer Ingelheim Pharmaceuticals, Inc. Synthesis for heteroarylamine compounds
AR038967A1 (es) * 2002-03-18 2005-02-02 Solvay Pharm Bv Derivados de 2,3 - diaril - pirazolidinas como inhibidores de enzimas que degradan la neurotensina
GB0225548D0 (en) 2002-11-01 2002-12-11 Glaxo Group Ltd Compounds
GB0323585D0 (en) * 2003-10-08 2003-11-12 Glaxo Group Ltd Compounds
US8084451B2 (en) * 2005-01-10 2011-12-27 University Of Connecticut Heteropyrrole analogs acting on cannabinoid receptors
US7714014B2 (en) * 2005-12-09 2010-05-11 The Regents Of The University Of California Targeting GLI proteins in human cancer by small molecules
CA2641441A1 (en) * 2006-02-09 2007-08-23 Athersys, Inc. Pyrazoles for the treatment of obesity and other cns disorders
EP2740726A1 (en) * 2012-12-07 2014-06-11 3B Pharmaceuticals GmbH Neurotensin receptor ligands
RU2705800C2 (ru) 2014-06-06 2019-11-12 Рисерч Трайэнгл Инститьют Агонисты рецептора апелина (apj) и их применение
MA43417A (fr) 2015-12-09 2018-10-17 Res Triangle Inst Agonistes améliorés du récepteur de l'apéline (apj) et leurs utilisations

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3719924A1 (de) * 1986-12-22 1988-06-30 Bayer Ag 8-substituierte 2-aminotetraline
PH27357A (en) * 1989-09-22 1993-06-21 Fujisawa Pharmaceutical Co Pyrazole derivatives and pharmaceutical compositions comprising the same
FR2665898B1 (fr) * 1990-08-20 1994-03-11 Sanofi Derives d'amido-3 pyrazole, procede pour leur preparation et compositions pharmaceutiques les contenant.
US5288877A (en) * 1991-07-03 1994-02-22 Ppg Industries, Inc. Continuous process for preparing indolenine compounds
IL104311A (en) * 1992-02-05 1997-07-13 Fujisawa Pharmaceutical Co Pyrazole derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same

Also Published As

Publication number Publication date
EP0647629B1 (fr) 1999-07-07
EP0647629A1 (fr) 1995-04-12
ZA947957B (en) 1995-05-22
FI944770A0 (fi) 1994-10-11
CA2117821A1 (en) 1995-04-13
IL111239A0 (en) 1994-12-29
NZ264661A (en) 1996-08-27
DE69419377D1 (de) 1999-08-12
ATE181911T1 (de) 1999-07-15
FR2711140B1 (fr) 1996-01-05
AU7575394A (en) 1995-05-04
JPH07278114A (ja) 1995-10-24
KR950011413A (ko) 1995-05-15
AU685154B2 (en) 1998-01-15
RU2140912C1 (ru) 1999-11-10
NO304595B1 (no) 1999-01-18
US5585497A (en) 1996-12-17
NO943837L (no) 1995-04-18
HU9402933D0 (en) 1995-01-30
US5523455A (en) 1996-06-04
FI944770A (fi) 1995-04-13
HUT70048A (en) 1995-09-28
US5502059A (en) 1996-03-26
TW300890B (ru) 1997-03-21
CN1108651A (zh) 1995-09-20
FR2711140A1 (fr) 1995-04-21
NO943837D0 (no) 1994-10-11

Similar Documents

Publication Publication Date Title
RU94036749A (ru) Замещенные 1-нафтилпиразол-3-карбоксамиды, способ их получения, содержащие их фармацевтические композиции и промежуточные соединения синтеза
RU94027577A (ru) Производные 1-бензолсульфонил-1,3-дигидро-2н-бензимидазол-2-она, способ их получения, содержащая их фармацевтическая композиция
RU94027576A (ru) Производные 1-бензолсульфонил-1,3-дигидро-индол-2-она, способ их получения и содержащие их фармацевтические композиции
BR9303993A (pt) Composto, processo para preparar o mesmo e composição farmacêutica
RU94046067A (ru) Замещенные 1,2,3,4-тетрагидроизохинолины, промежуточные продукты, фармкомпозиция и способ лечения
YU149791A (sh) Mometason, furoat monohidrat i postupak za njegovo dobijanje
IL123002A0 (en) 1-Phenyl-2- phenylacetoxy- ethanone derivatives
RU94038064A (ru) Производные пиперазина и пиперидина, их применение в качестве противопсихотических средств, способ их получения фармацевтическая композиция
IT1254915B (it) Derivati di adenosina ad attivita' a2 agonista
RU94028888A (ru) Производные 1,3-замещенного циклоалкана и циклоалкена, смесь их изомеров или индивидуальные изомеры, их гидраты и соли, способ их получения и фармацевтическая композиция
GEP19971265B (en) Substituted sulphonamides,, the substituted cyclic amines in the form of intermediate compounds for reception of the substituted sulphonamides and the pharmaceutical composition on the basis of the substituted sulphonamides displaying activity towards thromboxane receptors
ES2036926A1 (es) "procedimiento para la obtencion de derivados de la (2-alquil-3-piridil)metilpiperazina".
RU94044534A (ru) Амино-производные тиазола, способы их получения и содержащие их фармацевтические композиции
MD1560F2 (en) Cyclic compounds, pharmaceutical compositions on base thereof and methods of treatment of infections or diseases provoked by retroviruses.
JPS5665869A (en) Novel 22hydroxyalkyll3*4*55trihydroxyypiperidine compound* its manufacture and drug
MA21902A1 (fr) Procede pour la preparation de peptitides hemoregulateurs et des compositions pharmaceutiques les comtenant .
DE69410614T2 (de) Bis-naphthalimide für die behandlung von krebs
RU94046270A (ru) Лактамовые дипептиды, обладающие ингибирующей активностью по отношению к эластазе лейкоцитов человека, способ получения, фармацевтическая композиция
CA2107485A1 (fr) Nouveaux derives d'ellipticine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
RU95112519A (ru) (3,4-ди-фторфенокси)метил оксиран и способ его получения
PL328225A1 (en) Diphenylstilbenes as pro-medications used to produce cox-2-inhibitors
RU95107655A (ru) Глюкопиранозидбензотиофены, способ получения, фармацевтическая композиция
RU94000064A (ru) Новые 2-циано-3-гидроксипропенамиды, метод их получения и содержащие их фармацевтические композиции
RU95116448A (ru) Производные пирролидина, способ их получения и содержащие их лекарственные средства
MA21913A1 (fr) Procede de preparation de derives amino-oligohydroxy inhibiteurs de la renine .