DE69410614T2 - Bis-naphthalimide für die behandlung von krebs - Google Patents

Bis-naphthalimide für die behandlung von krebs

Info

Publication number
DE69410614T2
DE69410614T2 DE69410614T DE69410614T DE69410614T2 DE 69410614 T2 DE69410614 T2 DE 69410614T2 DE 69410614 T DE69410614 T DE 69410614T DE 69410614 T DE69410614 T DE 69410614T DE 69410614 T2 DE69410614 T2 DE 69410614T2
Authority
DE
Germany
Prior art keywords
cancer
treatment
naphthalimides
bis
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69410614T
Other languages
English (en)
Other versions
DE69410614D1 (de
Inventor
Gerhard Keilhauer
Cynthia Romerdahl
Brana Miguel Fernandez
Xiao-Dong Qian
Peter Bousquet
Berlanga Jose Castellano
Moset Marina Moran
DE VEGA Maria PEREZ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BASF SE
Original Assignee
BASF SE
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BASF SE filed Critical BASF SE
Publication of DE69410614D1 publication Critical patent/DE69410614D1/de
Application granted granted Critical
Publication of DE69410614T2 publication Critical patent/DE69410614T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/14—Aza-phenalenes, e.g. 1,8-naphthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Lubricants (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE69410614T 1993-08-18 1994-08-08 Bis-naphthalimide für die behandlung von krebs Expired - Fee Related DE69410614T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10894993A 1993-08-18 1993-08-18
PCT/EP1994/002621 WO1995005365A1 (en) 1993-08-18 1994-08-08 New bis-naphthalimides for the treatment of cancer

Publications (2)

Publication Number Publication Date
DE69410614D1 DE69410614D1 (de) 1998-07-02
DE69410614T2 true DE69410614T2 (de) 1998-09-24

Family

ID=22324990

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69410614T Expired - Fee Related DE69410614T2 (de) 1993-08-18 1994-08-08 Bis-naphthalimide für die behandlung von krebs

Country Status (28)

Country Link
US (3) US5616589A (de)
EP (1) EP0714387B1 (de)
JP (1) JPH09501662A (de)
KR (1) KR960703863A (de)
CN (1) CN1039414C (de)
AT (1) ATE166647T1 (de)
AU (1) AU677696B2 (de)
BR (2) BR9407257A (de)
CA (1) CA2169059A1 (de)
CZ (1) CZ34296A3 (de)
DE (1) DE69410614T2 (de)
DK (1) DK0714387T3 (de)
ES (1) ES2116612T3 (de)
FI (1) FI960658A (de)
HR (1) HRP940458B1 (de)
HU (1) HU219232B (de)
IL (1) IL110460A (de)
NO (1) NO305554B1 (de)
NZ (1) NZ271374A (de)
PH (1) PH31395A (de)
PL (1) PL313078A1 (de)
RU (1) RU2138484C1 (de)
SG (1) SG64906A1 (de)
SI (1) SI9420053A (de)
TW (1) TW408112B (de)
UA (1) UA42733C2 (de)
WO (1) WO1995005365A1 (de)
ZA (1) ZA946196B (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5703089A (en) * 1994-04-28 1997-12-30 Knoll Aktiengesellschaft Dihydrodibenzisoquinolinediones
NZ335291A (en) * 1996-10-21 2001-02-23 Allelix Biopharma Neurotrophin antagonist compositions
WO2000055166A1 (en) 1999-03-16 2000-09-21 Regents Of The University Of California Glycosylated polyamines
US6531454B1 (en) 1999-03-16 2003-03-11 The Regents Of The University Of California Glycosylated polyamines and methods of use therefor
US6492380B1 (en) * 1999-05-17 2002-12-10 Queen's University At Kingston Method of inhibiting neurotrophin-receptor binding
US6468990B1 (en) 1999-05-17 2002-10-22 Queen's University At Kingston Method of inhibiting binding of nerve growth factor to p75 NTR receptor
DE60100855T2 (de) * 2000-03-07 2004-07-15 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services 1,8-naphthalimid imidazo[4,5,1-de]acridone mit antitumorwirkung
WO2005044309A1 (en) 2003-11-05 2005-05-19 Photobiomed Corporation Bonding tissues and cross-linking proteins with naphthalimide compounds
AU2005238096A1 (en) * 2004-05-05 2005-11-10 Unibioscreen S.A. Naphthalimide derivatives, methods for their production and pharmaceutical compositions therefrom
US20070134243A1 (en) * 2004-12-01 2007-06-14 Gazzard Lewis J Antibody drug conjugates and methods
US7947839B2 (en) 2004-12-01 2011-05-24 Genentech, Inc. Heterocyclic-substituted bis-1,8 naphthalimide compounds, antibody drug conjugates, and methods of use
EP1817059A2 (de) 2004-12-01 2007-08-15 Genentech, Inc. Konjugate von 1,8-bis-naphthalimiden mit einem antikörper
KR20080058403A (ko) 2005-09-15 2008-06-25 페인셉터 파마 코포레이션 뉴로트로핀 매개 활성 조절 방법
WO2009089537A2 (en) 2008-01-11 2009-07-16 Northwestern University Anti-cancer compounds

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3535496A1 (de) * 1985-10-04 1987-04-16 Bayer Ag Verfahren zur fluoreszenzloeschung und neue kationische naphthalin-peri-dicarbonsaeureimid-derivate
DE3707651A1 (de) * 1987-03-10 1988-09-22 Knoll Ag Bis-naphthalimide, ihre herstellung und verwendung
US5086052A (en) * 1987-07-17 1992-02-04 Abbott Laboratories Substituted 1,4,5,6-tetrahydro-2H-pyridazin-3-one and -3-thione compounds having lipoxygenase inhibitory activity
US5086059A (en) * 1990-06-07 1992-02-04 Du Pont Merck Pharmaceutical Company Bis-naphthalimides as anticancer agents
US5206249A (en) * 1991-03-27 1993-04-27 Du Pont Merck Pharmaceutical Company Bis-naphthalimides containing amino-acid derived linkers as anticancer agents
WO1993012092A1 (en) * 1991-12-11 1993-06-24 The Du Pont Merck Pharmaceutical Company Highly water soluble bis-naphthalimides useful as anticancer agents
DE4232739A1 (de) * 1992-09-30 1994-03-31 Knoll Ag Neue asymmetrisch substituierte bis-Naphthalimide

Also Published As

Publication number Publication date
AU7498494A (en) 1995-03-14
FI960658A0 (fi) 1996-02-14
NO305554B1 (no) 1999-06-21
KR960703863A (ko) 1996-08-31
BR1100143A (pt) 2000-03-14
UA42733C2 (uk) 2001-11-15
CZ34296A3 (en) 1996-08-14
CA2169059A1 (en) 1995-02-23
HU9600360D0 (en) 1996-04-29
SG64906A1 (en) 1999-05-25
US5789418A (en) 1998-08-04
RU2138484C1 (ru) 1999-09-27
DK0714387T3 (da) 1998-10-12
HRP940458A2 (en) 1997-06-30
NZ271374A (en) 1997-05-26
CN1132506A (zh) 1996-10-02
IL110460A (en) 2001-01-11
DE69410614D1 (de) 1998-07-02
NO960632D0 (no) 1996-02-16
EP0714387A1 (de) 1996-06-05
PL313078A1 (en) 1996-05-27
US5981753A (en) 1999-11-09
SI9420053A (en) 1996-08-31
PH31395A (en) 1998-10-29
AU677696B2 (en) 1997-05-01
ES2116612T3 (es) 1998-07-16
NO960632L (no) 1996-02-16
US5616589A (en) 1997-04-01
ZA946196B (en) 1996-02-19
HUT73529A (en) 1996-08-28
EP0714387B1 (de) 1998-05-27
JPH09501662A (ja) 1997-02-18
IL110460A0 (en) 1994-10-21
BR9407257A (pt) 1996-09-24
HRP940458B1 (en) 2000-02-29
ATE166647T1 (de) 1998-06-15
HU219232B (en) 2001-03-28
TW408112B (en) 2000-10-11
WO1995005365A1 (en) 1995-02-23
FI960658A (fi) 1996-02-14
CN1039414C (zh) 1998-08-05

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee