DK0714387T3 - Hidtil ukendte bis-naphthalimider til behandling af cancer - Google Patents

Hidtil ukendte bis-naphthalimider til behandling af cancer

Info

Publication number
DK0714387T3
DK0714387T3 DK94924854T DK94924854T DK0714387T3 DK 0714387 T3 DK0714387 T3 DK 0714387T3 DK 94924854 T DK94924854 T DK 94924854T DK 94924854 T DK94924854 T DK 94924854T DK 0714387 T3 DK0714387 T3 DK 0714387T3
Authority
DK
Denmark
Prior art keywords
cancer
treatment
naphthalimides
known bis
newly known
Prior art date
Application number
DK94924854T
Other languages
English (en)
Inventor
Gerhard Keilhauer
Cynthia Romerdahl
Brana Miguel Fernandez
Xiao-Dong Qian
Peter Bousquet
Berlanga Jose Maria Castellano
Moset Marina Moran
De Vega Maria Jesus Perez
Original Assignee
Basf Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Ag filed Critical Basf Ag
Application granted granted Critical
Publication of DK0714387T3 publication Critical patent/DK0714387T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/14—Aza-phenalenes, e.g. 1,8-naphthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
DK94924854T 1993-08-18 1994-08-08 Hidtil ukendte bis-naphthalimider til behandling af cancer DK0714387T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10894993A 1993-08-18 1993-08-18
PCT/EP1994/002621 WO1995005365A1 (en) 1993-08-18 1994-08-08 New bis-naphthalimides for the treatment of cancer

Publications (1)

Publication Number Publication Date
DK0714387T3 true DK0714387T3 (da) 1998-10-12

Family

ID=22324990

Family Applications (1)

Application Number Title Priority Date Filing Date
DK94924854T DK0714387T3 (da) 1993-08-18 1994-08-08 Hidtil ukendte bis-naphthalimider til behandling af cancer

Country Status (28)

Country Link
US (3) US5616589A (da)
EP (1) EP0714387B1 (da)
JP (1) JPH09501662A (da)
KR (1) KR960703863A (da)
CN (1) CN1039414C (da)
AT (1) ATE166647T1 (da)
AU (1) AU677696B2 (da)
BR (2) BR9407257A (da)
CA (1) CA2169059A1 (da)
CZ (1) CZ34296A3 (da)
DE (1) DE69410614T2 (da)
DK (1) DK0714387T3 (da)
ES (1) ES2116612T3 (da)
FI (1) FI960658A0 (da)
HR (1) HRP940458B1 (da)
HU (1) HU219232B (da)
IL (1) IL110460A (da)
NO (1) NO305554B1 (da)
NZ (1) NZ271374A (da)
PH (1) PH31395A (da)
PL (1) PL313078A1 (da)
RU (1) RU2138484C1 (da)
SG (1) SG64906A1 (da)
SI (1) SI9420053A (da)
TW (1) TW408112B (da)
UA (1) UA42733C2 (da)
WO (1) WO1995005365A1 (da)
ZA (1) ZA946196B (da)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5703089A (en) * 1994-04-28 1997-12-30 Knoll Aktiengesellschaft Dihydrodibenzisoquinolinediones
CA2268450C (en) * 1996-10-21 2008-08-05 Allelix Biopharmaceuticals, Inc. Neurotrophin antagonist compositions
AU3883600A (en) 1999-03-16 2000-10-04 Regents Of The University Of California, The Glycosylated polyamines
US6531454B1 (en) 1999-03-16 2003-03-11 The Regents Of The University Of California Glycosylated polyamines and methods of use therefor
US6492380B1 (en) * 1999-05-17 2002-12-10 Queen's University At Kingston Method of inhibiting neurotrophin-receptor binding
US6468990B1 (en) 1999-05-17 2002-10-22 Queen's University At Kingston Method of inhibiting binding of nerve growth factor to p75 NTR receptor
EP1265898B1 (en) * 2000-03-07 2003-09-24 THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES 1,8-NAPHTHALIMIDE IMIDAZO 4,5,1- i de /i ]ACRIDONES WITH ANTI-TUMOR ACTIVITY
EP1689441A1 (en) 2003-11-05 2006-08-16 PhotoBioMed Corporation Bonding tissues and cross-linking proteins with naphthalimide compounds
AU2005238096A1 (en) * 2004-05-05 2005-11-10 Unibioscreen S.A. Naphthalimide derivatives, methods for their production and pharmaceutical compositions therefrom
US20070134243A1 (en) * 2004-12-01 2007-06-14 Gazzard Lewis J Antibody drug conjugates and methods
US7947839B2 (en) 2004-12-01 2011-05-24 Genentech, Inc. Heterocyclic-substituted bis-1,8 naphthalimide compounds, antibody drug conjugates, and methods of use
JP4993645B2 (ja) 2004-12-01 2012-08-08 ジェネンテック， インコーポレイテッド 抗体薬剤結合体および方法
KR20080058403A (ko) 2005-09-15 2008-06-25 페인셉터 파마 코포레이션 뉴로트로핀 매개 활성 조절 방법
WO2009089537A2 (en) 2008-01-11 2009-07-16 Northwestern University Anti-cancer compounds

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3535496A1 (de) * 1985-10-04 1987-04-16 Bayer Ag Verfahren zur fluoreszenzloeschung und neue kationische naphthalin-peri-dicarbonsaeureimid-derivate
DE3707651A1 (de) * 1987-03-10 1988-09-22 Knoll Ag Bis-naphthalimide, ihre herstellung und verwendung
US5086052A (en) * 1987-07-17 1992-02-04 Abbott Laboratories Substituted 1,4,5,6-tetrahydro-2H-pyridazin-3-one and -3-thione compounds having lipoxygenase inhibitory activity
US5086059A (en) * 1990-06-07 1992-02-04 Du Pont Merck Pharmaceutical Company Bis-naphthalimides as anticancer agents
US5206249A (en) * 1991-03-27 1993-04-27 Du Pont Merck Pharmaceutical Company Bis-naphthalimides containing amino-acid derived linkers as anticancer agents
JPH07501822A (ja) * 1991-12-11 1995-02-23 デュポン・ファーマシュウティカルズ・カンパニー 抗癌剤として有用な高度に水溶性のビス−ナフタルイミド
DE4232739A1 (de) * 1992-09-30 1994-03-31 Knoll Ag Neue asymmetrisch substituierte bis-Naphthalimide

Also Published As

Publication number Publication date
NZ271374A (en) 1997-05-26
HRP940458B1 (en) 2000-02-29
EP0714387B1 (en) 1998-05-27
SI9420053A (en) 1996-08-31
HU9600360D0 (en) 1996-04-29
US5616589A (en) 1997-04-01
ES2116612T3 (es) 1998-07-16
BR1100143A (pt) 2000-03-14
PH31395A (en) 1998-10-29
WO1995005365A1 (en) 1995-02-23
IL110460A0 (en) 1994-10-21
RU2138484C1 (ru) 1999-09-27
PL313078A1 (en) 1996-05-27
CN1132506A (zh) 1996-10-02
IL110460A (en) 2001-01-11
CA2169059A1 (en) 1995-02-23
SG64906A1 (en) 1999-05-25
NO305554B1 (no) 1999-06-21
HU219232B (en) 2001-03-28
NO960632L (no) 1996-02-16
US5789418A (en) 1998-08-04
CZ34296A3 (en) 1996-08-14
CN1039414C (zh) 1998-08-05
UA42733C2 (uk) 2001-11-15
AU7498494A (en) 1995-03-14
US5981753A (en) 1999-11-09
ZA946196B (en) 1996-02-19
JPH09501662A (ja) 1997-02-18
NO960632D0 (no) 1996-02-16
FI960658A (fi) 1996-02-14
FI960658A0 (fi) 1996-02-14
EP0714387A1 (en) 1996-06-05
ATE166647T1 (de) 1998-06-15
DE69410614D1 (de) 1998-07-02
DE69410614T2 (de) 1998-09-24
HUT73529A (en) 1996-08-28
AU677696B2 (en) 1997-05-01
TW408112B (en) 2000-10-11
HRP940458A2 (en) 1997-06-30
BR9407257A (pt) 1996-09-24
KR960703863A (ko) 1996-08-31

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