IL110460A - Bis-naphthalimides, their preparation and pharmaceutical compositions containing them - Google Patents
Bis-naphthalimides, their preparation and pharmaceutical compositions containing themInfo
- Publication number
- IL110460A IL110460A IL11046094A IL11046094A IL110460A IL 110460 A IL110460 A IL 110460A IL 11046094 A IL11046094 A IL 11046094A IL 11046094 A IL11046094 A IL 11046094A IL 110460 A IL110460 A IL 110460A
- Authority
- IL
- Israel
- Prior art keywords
- bis
- compound
- alkyl
- formula
- ethyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/06—Ring systems of three rings
- C07D221/14—Aza-phenalenes, e.g. 1,8-naphthalimide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Lubricants (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10894993A | 1993-08-18 | 1993-08-18 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL110460A0 IL110460A0 (en) | 1994-10-21 |
| IL110460A true IL110460A (en) | 2001-01-11 |
Family
ID=22324990
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL11046094A IL110460A (en) | 1993-08-18 | 1994-07-26 | Bis-naphthalimides, their preparation and pharmaceutical compositions containing them |
Country Status (28)
| Country | Link |
|---|---|
| US (3) | US5616589A (de) |
| EP (1) | EP0714387B1 (de) |
| JP (1) | JPH09501662A (de) |
| KR (1) | KR960703863A (de) |
| CN (1) | CN1039414C (de) |
| AT (1) | ATE166647T1 (de) |
| AU (1) | AU677696B2 (de) |
| BR (2) | BR9407257A (de) |
| CA (1) | CA2169059A1 (de) |
| CZ (1) | CZ34296A3 (de) |
| DE (1) | DE69410614T2 (de) |
| DK (1) | DK0714387T3 (de) |
| ES (1) | ES2116612T3 (de) |
| FI (1) | FI960658A7 (de) |
| HR (1) | HRP940458B1 (de) |
| HU (1) | HU219232B (de) |
| IL (1) | IL110460A (de) |
| NO (1) | NO305554B1 (de) |
| NZ (1) | NZ271374A (de) |
| PH (1) | PH31395A (de) |
| PL (1) | PL313078A1 (de) |
| RU (1) | RU2138484C1 (de) |
| SG (1) | SG64906A1 (de) |
| SI (1) | SI9420053A (de) |
| TW (1) | TW408112B (de) |
| UA (1) | UA42733C2 (de) |
| WO (1) | WO1995005365A1 (de) |
| ZA (1) | ZA946196B (de) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5703089A (en) * | 1994-04-28 | 1997-12-30 | Knoll Aktiengesellschaft | Dihydrodibenzisoquinolinediones |
| WO1998017278A1 (en) * | 1996-10-21 | 1998-04-30 | Allelix Biopharmaceuticals Inc. | Neurotrophin antagonist compositions |
| US6531454B1 (en) | 1999-03-16 | 2003-03-11 | The Regents Of The University Of California | Glycosylated polyamines and methods of use therefor |
| WO2000055166A1 (en) | 1999-03-16 | 2000-09-21 | Regents Of The University Of California | Glycosylated polyamines |
| US6492380B1 (en) | 1999-05-17 | 2002-12-10 | Queen's University At Kingston | Method of inhibiting neurotrophin-receptor binding |
| US6468990B1 (en) | 1999-05-17 | 2002-10-22 | Queen's University At Kingston | Method of inhibiting binding of nerve growth factor to p75 NTR receptor |
| US6664263B2 (en) | 2000-03-07 | 2003-12-16 | The United States Of America As Represented By The Department Of Health And Human Services | 1,8-naphthalimide imidazo{4,5,1-de}acridones with anti-tumor activity |
| EP1689441A1 (de) | 2003-11-05 | 2006-08-16 | PhotoBioMed Corporation | Verbindung von geweben und vernetzung von proteinen mit naphthalimid-verbindungen |
| MXPA06012660A (es) * | 2004-05-05 | 2007-03-23 | Unibioscreen Sa | Derivados de naftalimida para el tratamiento de cancer. |
| EP1817059A2 (de) | 2004-12-01 | 2007-08-15 | Genentech, Inc. | Konjugate von 1,8-bis-naphthalimiden mit einem antikörper |
| US7947839B2 (en) | 2004-12-01 | 2011-05-24 | Genentech, Inc. | Heterocyclic-substituted bis-1,8 naphthalimide compounds, antibody drug conjugates, and methods of use |
| US20070134243A1 (en) * | 2004-12-01 | 2007-06-14 | Gazzard Lewis J | Antibody drug conjugates and methods |
| BRPI0615930A2 (pt) | 2005-09-15 | 2016-08-23 | Painceptor Pharma Corp | métodos de modular a interação de uma neurotrofina e um receptor de neurotrofina, de tratar dor em um indivíduo, de tratar distúrbio inflamatório em um indivíduo, de tratar um distúrbio neurológico em um indivíduo, e de tratar uma doença ou distúrbio associado aos sistemas geniturinário e/ou gastrointestinal de um indivíduo, e, composto |
| US8420665B2 (en) | 2008-01-11 | 2013-04-16 | Northwestern University | Anti-cancer compounds |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3535496A1 (de) * | 1985-10-04 | 1987-04-16 | Bayer Ag | Verfahren zur fluoreszenzloeschung und neue kationische naphthalin-peri-dicarbonsaeureimid-derivate |
| DE3707651A1 (de) * | 1987-03-10 | 1988-09-22 | Knoll Ag | Bis-naphthalimide, ihre herstellung und verwendung |
| US5086052A (en) * | 1987-07-17 | 1992-02-04 | Abbott Laboratories | Substituted 1,4,5,6-tetrahydro-2H-pyridazin-3-one and -3-thione compounds having lipoxygenase inhibitory activity |
| US5086059A (en) * | 1990-06-07 | 1992-02-04 | Du Pont Merck Pharmaceutical Company | Bis-naphthalimides as anticancer agents |
| US5206249A (en) * | 1991-03-27 | 1993-04-27 | Du Pont Merck Pharmaceutical Company | Bis-naphthalimides containing amino-acid derived linkers as anticancer agents |
| CA2125142A1 (en) * | 1991-12-11 | 1993-06-24 | Jung-Hui Sun | Highly water soluble bis-naphthalimides useful as anticancer agents |
| DE4232739A1 (de) * | 1992-09-30 | 1994-03-31 | Knoll Ag | Neue asymmetrisch substituierte bis-Naphthalimide |
-
1994
- 1994-07-26 IL IL11046094A patent/IL110460A/en not_active IP Right Cessation
- 1994-08-05 TW TW083107200A patent/TW408112B/zh not_active IP Right Cessation
- 1994-08-08 DE DE69410614T patent/DE69410614T2/de not_active Expired - Fee Related
- 1994-08-08 JP JP7506722A patent/JPH09501662A/ja not_active Ceased
- 1994-08-08 CN CN94193569A patent/CN1039414C/zh not_active Expired - Fee Related
- 1994-08-08 DK DK94924854T patent/DK0714387T3/da active
- 1994-08-08 HU HU9600360A patent/HU219232B/hu not_active IP Right Cessation
- 1994-08-08 EP EP94924854A patent/EP0714387B1/de not_active Expired - Lifetime
- 1994-08-08 UA UA96030964A patent/UA42733C2/uk unknown
- 1994-08-08 CZ CZ96342A patent/CZ34296A3/cs unknown
- 1994-08-08 FI FI960658A patent/FI960658A7/fi unknown
- 1994-08-08 BR BR9407257A patent/BR9407257A/pt not_active Application Discontinuation
- 1994-08-08 ES ES94924854T patent/ES2116612T3/es not_active Expired - Lifetime
- 1994-08-08 SI SI9420053A patent/SI9420053A/sl unknown
- 1994-08-08 SG SG1996007469A patent/SG64906A1/en unknown
- 1994-08-08 CA CA002169059A patent/CA2169059A1/en not_active Abandoned
- 1994-08-08 PL PL94313078A patent/PL313078A1/xx unknown
- 1994-08-08 PH PH48763A patent/PH31395A/en unknown
- 1994-08-08 AT AT94924854T patent/ATE166647T1/de not_active IP Right Cessation
- 1994-08-08 AU AU74984/94A patent/AU677696B2/en not_active Ceased
- 1994-08-08 RU RU96105419A patent/RU2138484C1/ru active
- 1994-08-08 WO PCT/EP1994/002621 patent/WO1995005365A1/en not_active Ceased
- 1994-08-08 NZ NZ271374A patent/NZ271374A/en unknown
- 1994-08-09 US US08/287,421 patent/US5616589A/en not_active Expired - Fee Related
- 1994-08-11 HR HR08/108,949A patent/HRP940458B1/xx not_active IP Right Cessation
- 1994-08-17 ZA ZA946196A patent/ZA946196B/xx unknown
-
1996
- 1996-02-16 NO NO960632A patent/NO305554B1/no not_active IP Right Cessation
- 1996-02-17 KR KR1019960700836A patent/KR960703863A/ko not_active Abandoned
-
1997
- 1997-02-18 US US08/802,013 patent/US5789418A/en not_active Expired - Fee Related
- 1997-02-21 BR BR1100143-7A patent/BR1100143A/pt active IP Right Grant
- 1997-07-15 US US08/893,210 patent/US5981753A/en not_active Expired - Fee Related
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| MM9K | Patent not in force due to non-payment of renewal fees |