BRPI0510394A - inibidores de 11-beta-hidroxiesteróide desidrogenase tipo 1 - Google Patents

inibidores de 11-beta-hidroxiesteróide desidrogenase tipo 1

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Publication number
BRPI0510394A
BRPI0510394A BRPI0510394-0A BRPI0510394A BRPI0510394A BR PI0510394 A BRPI0510394 A BR PI0510394A BR PI0510394 A BRPI0510394 A BR PI0510394A BR PI0510394 A BRPI0510394 A BR PI0510394A
Authority
BR
Brazil
Prior art keywords
hydroxysteroid dehydrogenase
inhibitors
beta
compounds
dehydrogenase type
Prior art date
Application number
BRPI0510394-0A
Other languages
English (en)
Inventor
Martin Henriksson
Evert Homan
Lars Johansson
Jerk Vallgarda
Meredith Williams
Eric Bercot
Christopher H Fotsch
Aiwen Li
Guolin Cai
Randall W Hungate
Original Assignee
Amgen Inc
Biovitrum Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE0401324A external-priority patent/SE0401324D0/xx
Priority claimed from SE0402509A external-priority patent/SE0402509D0/xx
Application filed by Amgen Inc, Biovitrum Ab filed Critical Amgen Inc
Publication of BRPI0510394A publication Critical patent/BRPI0510394A/pt

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    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P17/00—Drugs for dermatological disorders
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    • A61P19/00—Drugs for skeletal disorders
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    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
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    • C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D275/03—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
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Abstract

INIBIDORES DE 11-BETA-HIDROXIESTERóIDE DESIDROGENASE TIPO 1. A presente invenção refere-se a compostos com as fórmula (I), (II), (III) ou (IV): em que R¬ 1¬, R¬ 2¬, R¬ 3¬, R¬ 4¬, R¬ 5¬, R¬ 6¬, R¬ 7¬, X e Z são como aqui definido, e também à composições farmacêuticas que compreendem os compostos, bem como métodos de uso dos compostos para tratamento de distúrbios associados com a enzima 11-<225>- hidroxiesteróide desidrogenase humana tipo 1 e para a preparação de um medicamento que age sobre a enzima 11-<225>-hidroxiesteróide desidrogenase humana tipo 1.
BRPI0510394-0A 2004-05-24 2005-05-24 inibidores de 11-beta-hidroxiesteróide desidrogenase tipo 1 BRPI0510394A (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
SE0401324A SE0401324D0 (sv) 2004-05-24 2004-05-24 New compounds
SE0402509A SE0402509D0 (sv) 2004-10-15 2004-10-15 New compounds
US65077705P 2005-01-31 2005-01-31
PCT/US2005/018081 WO2005116002A2 (en) 2004-05-24 2005-05-24 Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1

Publications (1)

Publication Number Publication Date
BRPI0510394A true BRPI0510394A (pt) 2007-11-13

Family

ID=35134299

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0510394-0A BRPI0510394A (pt) 2004-05-24 2005-05-24 inibidores de 11-beta-hidroxiesteróide desidrogenase tipo 1

Country Status (16)

Country Link
US (4) US20070281938A1 (pt)
EP (1) EP1753736B1 (pt)
JP (1) JP4789934B2 (pt)
CN (1) CN1964956B (pt)
AR (1) AR049344A1 (pt)
AT (1) ATE417837T1 (pt)
AU (1) AU2005247929B2 (pt)
BR (1) BRPI0510394A (pt)
CA (1) CA2568186C (pt)
DE (1) DE602005011795D1 (pt)
EA (1) EA014419B1 (pt)
ES (1) ES2318503T3 (pt)
GE (1) GEP20094666B (pt)
MY (1) MY148480A (pt)
TW (1) TWI352700B (pt)
WO (1) WO2005116002A2 (pt)

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