MX353954B - Aptameros y metodos de diagnostico para detectar el receptor del factor de crecimiento epidermal (egf). - Google Patents

Aptameros y metodos de diagnostico para detectar el receptor del factor de crecimiento epidermal (egf).

Info

Publication number
MX353954B
MX353954B MX2014007890A MX2014007890A MX353954B MX 353954 B MX353954 B MX 353954B MX 2014007890 A MX2014007890 A MX 2014007890A MX 2014007890 A MX2014007890 A MX 2014007890A MX 353954 B MX353954 B MX 353954B
Authority
MX
Mexico
Prior art keywords
aptamers
egf receptor
detecting
diagnostic methods
diagnostic
Prior art date
Application number
MX2014007890A
Other languages
English (en)
Other versions
MX2014007890A (es
Inventor
P Nikrad Malti
Nathu Gawande Bharat
Original Assignee
Somalogic Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Somalogic Inc filed Critical Somalogic Inc
Publication of MX2014007890A publication Critical patent/MX2014007890A/es
Publication of MX353954B publication Critical patent/MX353954B/es

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/16—Aptamers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/317—Chemical structure of the backbone with an inverted bond, e.g. a cap structure
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
    • C12N2310/3513—Protein; Peptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
    • C12N2310/3517—Marker; Tag
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00—Applications; Uses
    • C12N2320/10—Applications; Uses in screening processes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/71—Assays involving receptors, cell surface antigens or cell surface determinants for growth factors; for growth regulators
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Medicinal Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente invención se refiere a aptámeros que se unen específicamente al receptor del EGF en una muestra, y a métodos de diagnóstico y analíticos usando estos aptámeros.
MX2014007890A 2011-12-30 2012-12-28 Aptameros y metodos de diagnostico para detectar el receptor del factor de crecimiento epidermal (egf). MX353954B (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201161582111P 2011-12-30 2011-12-30
US201261649168P 2012-05-18 2012-05-18
US201261655404P 2012-06-04 2012-06-04
PCT/US2012/072101 WO2013102101A1 (en) 2011-12-30 2012-12-28 Aptamers and diagnostic methods for detecting the egf receptor

Publications (2)

Publication Number Publication Date
MX2014007890A MX2014007890A (es) 2014-09-26
MX353954B true MX353954B (es) 2018-02-07

Family

ID=48698659

Family Applications (3)

Application Number Title Priority Date Filing Date
MX2014008104A MX355567B (es) 2011-12-30 2012-12-28 Aptameros y metodos de diagnostico para detectar el receptor de egf.
MX2018004950A MX2018004950A (es) 2011-12-30 2012-12-28 Aptámeros y métodos de diagnóstico para detectar el receptor de egf.
MX2014007890A MX353954B (es) 2011-12-30 2012-12-28 Aptameros y metodos de diagnostico para detectar el receptor del factor de crecimiento epidermal (egf).

Family Applications Before (2)

Application Number Title Priority Date Filing Date
MX2014008104A MX355567B (es) 2011-12-30 2012-12-28 Aptameros y metodos de diagnostico para detectar el receptor de egf.
MX2018004950A MX2018004950A (es) 2011-12-30 2012-12-28 Aptámeros y métodos de diagnóstico para detectar el receptor de egf.

Country Status (4)

Country Link
US (3) US9651556B2 (es)
EP (3) EP3335714A1 (es)
MX (3) MX355567B (es)
WO (2) WO2013102096A1 (es)

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BR112016005957A2 (pt) 2013-09-24 2017-09-26 Somalogic Inc detecção de alvo multiaptâmero
KR101680335B1 (ko) 2015-05-29 2016-11-28 포항공과대학교 산학협력단 상피세포 성장인자 수용체 압타머 및 이를 포함하는 항암제 조성물
WO2017127761A1 (en) 2016-01-20 2017-07-27 Vitrisa Therapeutics, Inc. Compositions and methods for inhibiting factor d
KR101859615B1 (ko) * 2016-07-14 2018-05-18 충북대학교 산학협력단 표피 성장 인자 수용체 특이적 결합 dna 앱타머 및 이의 용도
WO2018136827A1 (en) 2017-01-20 2018-07-26 Vitrisa Therapeutics, Inc. Stem-loop compositions and methods for inhibiting factor d
WO2019022986A1 (en) * 2017-07-24 2019-01-31 Vitrisa Therapeutics, Inc. NUCLEIC ACID COMPOSITIONS AND METHODS OF INHIBITING D-FACTOR
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RU2736790C1 (ru) * 2019-10-31 2020-11-20 Общество С Ограниченной Ответственностью "Апто-Фарм" Модифицированные 50-звенные ДНК-аптамеры, связывающие внеклеточный домен EGFR

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Also Published As

Publication number Publication date
US20170328909A1 (en) 2017-11-16
MX355567B (es) 2018-04-23
WO2013102096A1 (en) 2013-07-04
US10620210B2 (en) 2020-04-14
EP2797603A4 (en) 2015-07-08
EP2797603A1 (en) 2014-11-05
US9316647B2 (en) 2016-04-19
EP2797603B1 (en) 2019-02-20
MX2018004950A (es) 2022-01-24
US9651556B2 (en) 2017-05-16
WO2013102101A1 (en) 2013-07-04
US20140296501A1 (en) 2014-10-02
MX2014008104A (es) 2015-09-25
EP2798085A4 (en) 2015-07-01
EP2798085B1 (en) 2018-01-24
MX2014007890A (es) 2014-09-26
EP3335714A1 (en) 2018-06-20
US20150086996A1 (en) 2015-03-26
EP2798085A1 (en) 2014-11-05

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