MX370134B - Enzimas de cetol-acido reductoisomerasa y metodo de uso. - Google Patents
Enzimas de cetol-acido reductoisomerasa y metodo de uso.Info
- Publication number
- MX370134B MX370134B MX2018004620A MX2018004620A MX370134B MX 370134 B MX370134 B MX 370134B MX 2018004620 A MX2018004620 A MX 2018004620A MX 2018004620 A MX2018004620 A MX 2018004620A MX 370134 B MX370134 B MX 370134B
- Authority
- MX
- Mexico
- Prior art keywords
- ketol
- methods
- acid reductoisomerase
- polypeptides
- reductoisomerase enzymes
- Prior art date
Links
- 108010000200 Ketol-acid reductoisomerase Proteins 0.000 title abstract 2
- 229920001184 polypeptide Polymers 0.000 abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 3
- 230000006696 biosynthetic metabolic pathway Effects 0.000 abstract 2
- ZXEKIIBDNHEJCQ-UHFFFAOYSA-N isobutanol Chemical compound CC(C)CO ZXEKIIBDNHEJCQ-UHFFFAOYSA-N 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 1
- 230000000813 microbial effect Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/06—Alanine; Leucine; Isoleucine; Serine; Homoserine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
- C12P7/16—Butanols
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/42—Hydroxy-carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/44—Polycarboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
- C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
- C12Y101/01086—Ketol-acid reductoisomerase (1.1.1.86)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/645—Fungi ; Processes using fungi
- C12R2001/85—Saccharomyces
- C12R2001/865—Saccharomyces cerevisiae
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
- Y02E50/00—Technologies for the production of fuel of non-fossil origin
- Y02E50/10—Biofuels, e.g. bio-diesel
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
La presente invención se refiere a polipéptidos que tienen actividad cetol-ácido reductoisomerasa así como células hospederas microbianas que comprenden tales polipéptidos. Los polipéptidos proporcionados en la presente descripción pueden usarse en rutas biosintéticas que incluyen, pero no se limitan a, las rutas biosintéticas del isobutanol.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261645832P | 2012-05-11 | 2012-05-11 | |
| US201361787480P | 2013-03-15 | 2013-03-15 | |
| PCT/US2013/040627 WO2013176909A2 (en) | 2012-05-11 | 2013-05-10 | Ketol-acid reductoisomerase enzymes and methods of use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX370134B true MX370134B (es) | 2019-12-03 |
Family
ID=48877508
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2018004620A MX370134B (es) | 2012-05-11 | 2013-05-10 | Enzimas de cetol-acido reductoisomerasa y metodo de uso. |
| MX2014013446A MX2014013446A (es) | 2012-05-11 | 2013-05-10 | Enzimas de cetol-acido reductoisomerasa y metodos de uso. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2014013446A MX2014013446A (es) | 2012-05-11 | 2013-05-10 | Enzimas de cetol-acido reductoisomerasa y metodos de uso. |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US9169467B2 (es) |
| EP (1) | EP2847326A2 (es) |
| JP (1) | JP6321631B2 (es) |
| KR (1) | KR20150014953A (es) |
| CN (1) | CN104619835B (es) |
| AU (1) | AU2013266727A1 (es) |
| BR (1) | BR112014028153A2 (es) |
| CA (1) | CA2873109A1 (es) |
| MX (2) | MX370134B (es) |
| NZ (1) | NZ701099A (es) |
| WO (1) | WO2013176909A2 (es) |
| ZA (1) | ZA201407713B (es) |
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| US8945899B2 (en) | 2007-12-20 | 2015-02-03 | Butamax Advanced Biofuels Llc | Ketol-acid reductoisomerase using NADH |
| NZ579780A (en) | 2007-04-18 | 2012-07-27 | Butamax Advanced Biofuels Llc | Fermentive production of isobutanol using highly active ketol-acid reductoisomerase enzymes |
| US8188250B2 (en) | 2008-04-28 | 2012-05-29 | Butamax(Tm) Advanced Biofuels Llc | Butanol dehydrogenase enzyme from the bacterium Achromobacter xylosoxidans |
| MX2011003313A (es) | 2008-09-29 | 2011-06-16 | Butamax Tm Advanced Biofuels | Actividad enzimatica de fe-s heterologa aumentada en levadura. |
| MX2012007583A (es) | 2009-12-29 | 2012-07-30 | Butamax Tm Advanced Biofuels | Alcohol deshidrogenasas (adh) utiles para la produccion fermentativa de alcoholes alquilicos de cadena corta. |
| KR20130027063A (ko) | 2010-02-17 | 2013-03-14 | 부타맥스 어드밴스드 바이오퓨얼스 엘엘씨 | Fe-s 클러스터 요구성 단백질의 활성 향상 |
| EP2614138B1 (en) | 2010-09-07 | 2017-08-30 | Butamax (TM) Advanced Biofuels LLC | Integration of a polynucleotide encoding a polypeptide that catalyzes pyruvate to acetolactate conversion |
| BR112013024328A2 (pt) | 2011-03-24 | 2020-08-25 | Butamax (Tm) Advanced Biofuels Llc. | Células hospedeiras recombinantes, métodos para produzir isobutanol, composiçãofermentativa, métodos para produzir uma célula hospedeira recombinante, para reduzir oueliminar a conversão de isobutiraldeído, polipeptídeos, polinucleqtídeo, método paraconverter acetolactato, leveduras recombinantes, métodos para produzir butanol, paraaumentar a atividade e para aumentar a produtividade da enzima karl |
| EP2737073B1 (en) | 2011-07-28 | 2021-10-20 | Butamax Advanced Biofuels LLC | Keto-isovalerate decarboxylase enzymes and methods of use thereof |
| CN104321436A (zh) | 2011-12-30 | 2015-01-28 | 布特马斯先进生物燃料有限责任公司 | 醇类的发酵生产 |
| BR112014023603A8 (pt) | 2012-03-23 | 2017-07-25 | Butamax Advanced Biofuels Llc | Método para produção de butanol e composição |
| AU2013266727A1 (en) | 2012-05-11 | 2014-11-06 | Butamax Advanced Biofuels Llc | Ketol-acid reductoisomerase enzymes and methods of use |
| BR112015003701A2 (pt) | 2012-08-22 | 2017-12-12 | Butamax Advanced Biofuels Llc | células hospedeiras recombinantes, método para aprimoramento, processo para a produção de um álcool, polinucleotídeo isolado, cassete de expressão e composição |
| US9840724B2 (en) | 2012-09-21 | 2017-12-12 | Butamax Advanced Biofuels Llc | Production of renewable hydrocarbon compositions |
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| KR101960501B1 (ko) * | 2017-09-15 | 2019-03-21 | 고려대학교 산학협력단 | Nadh 친화적인 신규 케톨산 리덕토아이소머라제 |
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| US20110195505A1 (en) | 2009-10-08 | 2011-08-11 | Butamax(Tm) Advanced Biofuels Llc | Bacterial strains for butanol production |
| CA2781131C (en) | 2009-11-24 | 2017-01-03 | Gevo, Inc. | Methods of increasing dihydroxy acid dehydratase activity to improve production of fuels, chemicals, and amino acids |
| CA2785660A1 (en) | 2009-12-29 | 2011-07-07 | Butamax(Tm) Advanced Biofuels Llc | Expression of hexose kinase in recombinant host cells |
| MX2012007583A (es) | 2009-12-29 | 2012-07-30 | Butamax Tm Advanced Biofuels | Alcohol deshidrogenasas (adh) utiles para la produccion fermentativa de alcoholes alquilicos de cadena corta. |
| MY159487A (en) | 2010-02-12 | 2017-01-13 | Gevo Inc | Reduced by-product accumulation for improved production of isobutanol |
| KR20130027063A (ko) | 2010-02-17 | 2013-03-14 | 부타맥스 어드밴스드 바이오퓨얼스 엘엘씨 | Fe-s 클러스터 요구성 단백질의 활성 향상 |
| CN103201376A (zh) | 2010-06-17 | 2013-07-10 | 布特马斯先进生物燃料有限责任公司 | 用于生产丁醇的酵母生产培养物 |
| US8871488B2 (en) | 2010-06-18 | 2014-10-28 | Butamax Advanced Biofuels Llc | Recombinant host cells comprising phosphoketolases |
| EP2614138B1 (en) | 2010-09-07 | 2017-08-30 | Butamax (TM) Advanced Biofuels LLC | Integration of a polynucleotide encoding a polypeptide that catalyzes pyruvate to acetolactate conversion |
| BR112013024328A2 (pt) | 2011-03-24 | 2020-08-25 | Butamax (Tm) Advanced Biofuels Llc. | Células hospedeiras recombinantes, métodos para produzir isobutanol, composiçãofermentativa, métodos para produzir uma célula hospedeira recombinante, para reduzir oueliminar a conversão de isobutiraldeído, polipeptídeos, polinucleqtídeo, método paraconverter acetolactato, leveduras recombinantes, métodos para produzir butanol, paraaumentar a atividade e para aumentar a produtividade da enzima karl |
| US20120258873A1 (en) | 2011-04-06 | 2012-10-11 | Butamax(Tm) Advanced Biofuels Llc | Reduction of 2,3-dihydroxy-2-methyl butyrate (dhmb) in butanol production |
| US20130035515A1 (en) | 2011-06-17 | 2013-02-07 | Butamax(Tm) Advanced Biofuels Llc | Lignocellulosic hydrolysates as feedstocks for isobutanol fermentation |
| EP2737073B1 (en) | 2011-07-28 | 2021-10-20 | Butamax Advanced Biofuels LLC | Keto-isovalerate decarboxylase enzymes and methods of use thereof |
| US9181566B2 (en) | 2011-12-30 | 2015-11-10 | Butamax Advanced Biofuels Llc | Genetic switches for butanol production |
| CN104321436A (zh) | 2011-12-30 | 2015-01-28 | 布特马斯先进生物燃料有限责任公司 | 醇类的发酵生产 |
| BR112014023603A8 (pt) | 2012-03-23 | 2017-07-25 | Butamax Advanced Biofuels Llc | Método para produção de butanol e composição |
| AU2013266727A1 (en) | 2012-05-11 | 2014-11-06 | Butamax Advanced Biofuels Llc | Ketol-acid reductoisomerase enzymes and methods of use |
| CA2886157A1 (en) | 2012-09-26 | 2014-04-03 | Butamax Advanced Biofuels Llc | Polypeptides with ketol-acid reductoisomerase activity |
| US9273330B2 (en) | 2012-10-03 | 2016-03-01 | Butamax Advanced Biofuels Llc | Butanol tolerance in microorganisms |
| US20140186911A1 (en) | 2012-12-28 | 2014-07-03 | Butamax Advanced Biofuels Llc | Recombinant host cells and methods for producing butanol |
| WO2014106107A2 (en) | 2012-12-28 | 2014-07-03 | Butamax (Tm) Advanced Biofuels Llc | Dhad variants for butanol production |
| EP2970863B1 (en) | 2013-03-14 | 2019-04-24 | E. I. du Pont de Nemours and Company | Glycerol 3- phosphate dehydrogenase for butanol production |
| WO2014151190A1 (en) | 2013-03-15 | 2014-09-25 | Butamax Advanced Biofuels Llc | Dhad variants and methods of screening |
-
2013
- 2013-05-10 AU AU2013266727A patent/AU2013266727A1/en not_active Abandoned
- 2013-05-10 MX MX2018004620A patent/MX370134B/es unknown
- 2013-05-10 NZ NZ701099A patent/NZ701099A/en not_active IP Right Cessation
- 2013-05-10 MX MX2014013446A patent/MX2014013446A/es unknown
- 2013-05-10 WO PCT/US2013/040627 patent/WO2013176909A2/en not_active Ceased
- 2013-05-10 US US13/891,963 patent/US9169467B2/en active Active
- 2013-05-10 BR BR112014028153-0A patent/BR112014028153A2/pt not_active Application Discontinuation
- 2013-05-10 EP EP13742293.7A patent/EP2847326A2/en not_active Withdrawn
- 2013-05-10 KR KR1020147034485A patent/KR20150014953A/ko not_active Withdrawn
- 2013-05-10 JP JP2015511775A patent/JP6321631B2/ja active Active
- 2013-05-10 CN CN201380036539.6A patent/CN104619835B/zh not_active Expired - Fee Related
- 2013-05-10 CA CA2873109A patent/CA2873109A1/en not_active Abandoned
-
2014
- 2014-10-23 ZA ZA2014/07713A patent/ZA201407713B/en unknown
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2015
- 2015-09-14 US US14/853,108 patent/US9388392B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| KR20150014953A (ko) | 2015-02-09 |
| JP2015517310A (ja) | 2015-06-22 |
| CA2873109A1 (en) | 2013-11-28 |
| US9388392B2 (en) | 2016-07-12 |
| ZA201407713B (en) | 2016-05-25 |
| AU2013266727A1 (en) | 2014-11-06 |
| CN104619835A (zh) | 2015-05-13 |
| US9169467B2 (en) | 2015-10-27 |
| WO2013176909A3 (en) | 2014-02-13 |
| NZ701099A (en) | 2017-04-28 |
| BR112014028153A2 (pt) | 2018-05-08 |
| WO2013176909A2 (en) | 2013-11-28 |
| JP6321631B2 (ja) | 2018-05-09 |
| CN104619835B (zh) | 2018-06-19 |
| EP2847326A2 (en) | 2015-03-18 |
| MX2014013446A (es) | 2014-12-08 |
| US20160032255A1 (en) | 2016-02-04 |
| US20140051133A1 (en) | 2014-02-20 |
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