MX2015012842A - Prodecimiento para preparar inhibidores de la glucosilceramida sintasa. - Google Patents
Prodecimiento para preparar inhibidores de la glucosilceramida sintasa.Info
- Publication number
- MX2015012842A MX2015012842A MX2015012842A MX2015012842A MX2015012842A MX 2015012842 A MX2015012842 A MX 2015012842A MX 2015012842 A MX2015012842 A MX 2015012842A MX 2015012842 A MX2015012842 A MX 2015012842A MX 2015012842 A MX2015012842 A MX 2015012842A
- Authority
- MX
- Mexico
- Prior art keywords
- glucosylceramide synthase
- synthase inhibitors
- preparing
- preparing glucosylceramide
- treatment
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Epidemiology (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
La invención se refiere a un procedimiento para preparar inhibidores de la glucosilceramida sintasa (GCS) útiles para el tratamiento de enfermedades metabólicas, tales como las enfermedades de almacenamiento lisosomal (tesaurismosis), ya sea solo o en combinación con terapia de reemplazo enzimático, y para el tratamiento del cáncer.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361791913P | 2013-03-15 | 2013-03-15 | |
| PCT/US2014/025384 WO2014151291A1 (en) | 2013-03-15 | 2014-03-13 | Method of preparing glucosylceramide synthase inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2015012842A true MX2015012842A (es) | 2016-02-03 |
| MX365464B MX365464B (es) | 2019-06-04 |
Family
ID=50543333
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2015012842A MX365464B (es) | 2013-03-15 | 2014-03-13 | Prodecimiento para preparar inhibidores de la glucosilceramida sintasa. |
Country Status (21)
| Country | Link |
|---|---|
| US (4) | US9682975B2 (es) |
| EP (2) | EP3514157B1 (es) |
| JP (2) | JP6543242B2 (es) |
| KR (1) | KR20150130386A (es) |
| CN (2) | CN108658970A (es) |
| AR (1) | AR095436A1 (es) |
| AU (2) | AU2014235132B2 (es) |
| BR (1) | BR112015020667A2 (es) |
| CA (2) | CA2906581C (es) |
| CY (1) | CY1121859T1 (es) |
| DK (1) | DK3514157T3 (es) |
| ES (2) | ES2727869T3 (es) |
| HK (1) | HK1220689A1 (es) |
| HU (2) | HUE064200T2 (es) |
| IL (2) | IL240617B (es) |
| MX (1) | MX365464B (es) |
| RU (1) | RU2015144035A (es) |
| SG (2) | SG11201506415XA (es) |
| TW (2) | TW201900625A (es) |
| UY (1) | UY35438A (es) |
| WO (1) | WO2014151291A1 (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JOP20130273B1 (ar) | 2012-09-11 | 2021-08-17 | Genzyme Corp | مثبطات انزيم (سينثاز) غلوكوسيل سيراميد |
| HUE064200T2 (hu) | 2013-03-15 | 2024-02-28 | Genzyme Corp | Eljárás glukozilceramid szintáz inhibitorok elõállítására |
| US10991982B2 (en) * | 2017-02-17 | 2021-04-27 | Westfälische Wilhelms-Universität Münster | Electrolyte-additive for lithium-ion battery systems |
| JP2021506920A (ja) | 2017-12-21 | 2021-02-22 | リソソーマル・セラピューティクス・インコーポレイテッドＬｙｓｏｓｏｍａｌ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｉｎｃ． | 結晶性の置換シクロヘキシルピラゾロ［１，５−ａ］ピリミジニルカルボキサミド化合物およびその治療的使用 |
| US10519157B2 (en) * | 2018-02-09 | 2019-12-31 | X-Cutag Therapeutics, Inc. | Deuterated compounds for treating Fabry, Gaucher, Parkinson's and related diseases and conditions, and compositions and methods thereof |
| CN115427038A (zh) | 2020-02-03 | 2022-12-02 | 建新公司 | 治疗与溶酶体贮积病相关的神经系统症状的方法 |
| WO2021221953A1 (en) | 2020-04-28 | 2021-11-04 | The Regents Of The University Of Michigan | Pyridine inhibitors of glucosylceramide synthase and therapeutic methods using the same |
| BR112023000798A2 (pt) | 2020-07-24 | 2023-02-07 | Genzyme Corp | Composições farmacêuticas compreendendo venglustat |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB725226A (en) * | 1952-06-03 | 1955-03-02 | Berger Brothers Co | Improvements in or relating to an inflatable surgical pad |
| GB725228A (en) * | 1952-06-19 | 1955-03-02 | Roche Products Ltd | Substituted carbamic acid esters and process for the manufacture thereof |
| NL130759C (es) * | 1965-10-07 | |||
| DE4326510A1 (de) * | 1993-08-06 | 1995-02-09 | Bayer Ag | Verfahren zur Herstellung von Cyclohexen-Derivaten |
| CA2182568A1 (en) * | 1994-02-10 | 1995-08-17 | Makoto Takeuchi | Novel carbamate derivative and medicinal composition containing the same |
| JPH08198751A (ja) * | 1995-01-19 | 1996-08-06 | Yamanouchi Pharmaceut Co Ltd | カルバメート誘導体 |
| SE9600683D0 (sv) * | 1996-02-23 | 1996-02-23 | Astra Ab | Azabicyclic esters of carbamic acids useful in therapy |
| GB0400812D0 (en) | 2004-01-14 | 2004-02-18 | Celltech R&D Ltd | Novel compounds |
| JP2008519840A (ja) | 2004-11-10 | 2008-06-12 | ジェンザイム・コーポレイション | 糖尿病の処置方法 |
| JP5285643B2 (ja) * | 2010-03-15 | 2013-09-11 | シャープ株式会社 | 半導体集積回路および電子情報機器 |
| MX338392B (es) * | 2010-11-12 | 2016-04-13 | Shionogi & Co | Cristal de derivado de 6,7-insaturado-7-carbamoil morfinano y metodo para producir el mismo. |
| ES2774293T3 (es) | 2011-03-18 | 2020-07-20 | Genzyme Corp | Inhibidores de la glucosilceramida sintasa |
| CN103702997A (zh) * | 2011-06-22 | 2014-04-02 | 伊索凯姆公司 | 索非那新及其盐的制备方法 |
| JP2013053228A (ja) * | 2011-09-02 | 2013-03-21 | Asahi Kasei E-Materials Corp | エポキシ樹脂用硬化剤及びマイクロカプセル型エポキシ樹脂用硬化剤 |
| JOP20130273B1 (ar) | 2012-09-11 | 2021-08-17 | Genzyme Corp | مثبطات انزيم (سينثاز) غلوكوسيل سيراميد |
| HUE064200T2 (hu) * | 2013-03-15 | 2024-02-28 | Genzyme Corp | Eljárás glukozilceramid szintáz inhibitorok elõállítására |
-
2014
- 2014-03-13 HU HUE19153389A patent/HUE064200T2/hu unknown
- 2014-03-13 BR BR112015020667A patent/BR112015020667A2/pt not_active Application Discontinuation
- 2014-03-13 CN CN201810630738.4A patent/CN108658970A/zh active Pending
- 2014-03-13 SG SG11201506415XA patent/SG11201506415XA/en unknown
- 2014-03-13 CN CN201480026302.4A patent/CN105189491B/zh active Active
- 2014-03-13 CA CA2906581A patent/CA2906581C/en active Active
- 2014-03-13 WO PCT/US2014/025384 patent/WO2014151291A1/en active Application Filing
- 2014-03-13 EP EP19153389.2A patent/EP3514157B1/en active Active
- 2014-03-13 US US14/776,443 patent/US9682975B2/en active Active
- 2014-03-13 JP JP2016501840A patent/JP6543242B2/ja active Active
- 2014-03-13 RU RU2015144035A patent/RU2015144035A/ru not_active Application Discontinuation
- 2014-03-13 SG SG10201706575UA patent/SG10201706575UA/en unknown
- 2014-03-13 DK DK19153389.2T patent/DK3514157T3/da active
- 2014-03-13 TW TW107132577A patent/TW201900625A/zh unknown
- 2014-03-13 CA CA3092901A patent/CA3092901C/en active Active
- 2014-03-13 EP EP14718835.3A patent/EP2970251B1/en active Active
- 2014-03-13 AR ARP140100982A patent/AR095436A1/es unknown
- 2014-03-13 ES ES14718835T patent/ES2727869T3/es active Active
- 2014-03-13 KR KR1020157027836A patent/KR20150130386A/ko not_active Application Discontinuation
- 2014-03-13 HU HUE14718835A patent/HUE043394T2/hu unknown
- 2014-03-13 ES ES19153389T patent/ES2968073T3/es active Active
- 2014-03-13 AU AU2014235132A patent/AU2014235132B2/en not_active Ceased
- 2014-03-13 MX MX2015012842A patent/MX365464B/es active IP Right Grant
- 2014-03-13 TW TW103108899A patent/TWI649317B/zh not_active IP Right Cessation
- 2014-03-14 UY UY0001035438A patent/UY35438A/es not_active Application Discontinuation
-
2015
- 2015-08-17 IL IL240617A patent/IL240617B/en active IP Right Grant
-
2016
- 2016-07-20 HK HK16108676.6A patent/HK1220689A1/zh not_active IP Right Cessation
-
2017
- 2017-05-12 US US15/593,440 patent/US10065949B2/en active Active
-
2018
- 2018-06-03 IL IL259770A patent/IL259770B/en active IP Right Grant
- 2018-08-01 US US16/051,892 patent/US10604518B2/en active Active
-
2019
- 2019-01-18 AU AU2019200350A patent/AU2019200350A1/en not_active Abandoned
- 2019-05-27 CY CY20191100562T patent/CY1121859T1/el unknown
- 2019-06-13 JP JP2019109986A patent/JP6813626B2/ja active Active
-
2020
- 2020-02-14 US US16/791,854 patent/US10954230B2/en active Active
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |