MX365464B - Prodecimiento para preparar inhibidores de la glucosilceramida sintasa. - Google Patents

Prodecimiento para preparar inhibidores de la glucosilceramida sintasa.

Info

Publication number
MX365464B
MX365464B MX2015012842A MX2015012842A MX365464B MX 365464 B MX365464 B MX 365464B MX 2015012842 A MX2015012842 A MX 2015012842A MX 2015012842 A MX2015012842 A MX 2015012842A MX 365464 B MX365464 B MX 365464B
Authority
MX
Mexico
Prior art keywords
glucosylceramide synthase
synthase inhibitors
preparing
preparing glucosylceramide
treatment
Prior art date
Application number
MX2015012842A
Other languages
English (en)
Other versions
MX2015012842A (es
Inventor
Siegel Craig
Zhao Jin
Gimi Rayomand
Reardon Michael
Original Assignee
Genzyme Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genzyme Corp filed Critical Genzyme Corp
Publication of MX2015012842A publication Critical patent/MX2015012842A/es
Publication of MX365464B publication Critical patent/MX365464B/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D453/00Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/30Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Epidemiology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

La invención se refiere a un procedimiento para preparar inhibidores de la glucosilceramida sintasa (GCS) útiles para el tratamiento de enfermedades metabólicas, tales como las enfermedades de almacenamiento lisosomal (tesaurismosis), ya sea solo o en combinación con terapia de reemplazo enzimático, y para el tratamiento del cáncer.
MX2015012842A 2013-03-15 2014-03-13 Prodecimiento para preparar inhibidores de la glucosilceramida sintasa. MX365464B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361791913P 2013-03-15 2013-03-15
PCT/US2014/025384 WO2014151291A1 (en) 2013-03-15 2014-03-13 Method of preparing glucosylceramide synthase inhibitors

Publications (2)

Publication Number Publication Date
MX2015012842A MX2015012842A (es) 2016-02-03
MX365464B true MX365464B (es) 2019-06-04

Family

ID=50543333

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015012842A MX365464B (es) 2013-03-15 2014-03-13 Prodecimiento para preparar inhibidores de la glucosilceramida sintasa.

Country Status (21)

Country Link
US (4) US9682975B2 (es)
EP (2) EP2970251B1 (es)
JP (2) JP6543242B2 (es)
KR (1) KR20150130386A (es)
CN (2) CN108658970A (es)
AR (1) AR095436A1 (es)
AU (2) AU2014235132B2 (es)
BR (1) BR112015020667A2 (es)
CA (2) CA3092901C (es)
CY (1) CY1121859T1 (es)
DK (1) DK3514157T3 (es)
ES (2) ES2968073T3 (es)
HK (1) HK1220689A1 (es)
HU (2) HUE043394T2 (es)
IL (2) IL240617B (es)
MX (1) MX365464B (es)
RU (1) RU2015144035A (es)
SG (2) SG10201706575UA (es)
TW (2) TW201900625A (es)
UY (1) UY35438A (es)
WO (1) WO2014151291A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JOP20130273B1 (ar) 2012-09-11 2021-08-17 Genzyme Corp مثبطات انزيم (سينثاز) غلوكوسيل سيراميد
KR20150130386A (ko) 2013-03-15 2015-11-23 젠자임 코포레이션 글루코실세라마이드 신타아제 저해제의 제조 방법
EP3583653B1 (de) * 2017-02-17 2020-12-16 Westfälische Wilhelms-Universität Münster Elektrolyt-zusatz für lithium-ionen-batterien
JP2021506920A (ja) 2017-12-21 2021-02-22 リソソーマル・セラピューティクス・インコーポレイテッドLysosomal Therapeutics Inc. 結晶性の置換シクロヘキシルピラゾロ[1,5−a]ピリミジニルカルボキサミド化合物およびその治療的使用
US10519157B2 (en) * 2018-02-09 2019-12-31 X-Cutag Therapeutics, Inc. Deuterated compounds for treating Fabry, Gaucher, Parkinson's and related diseases and conditions, and compositions and methods thereof
IL295255A (en) 2020-02-03 2022-10-01 Genzyme Corp Methods for treating neurological symptoms associated with lysosomal storage diseases
WO2021221953A1 (en) 2020-04-28 2021-11-04 The Regents Of The University Of Michigan Pyridine inhibitors of glucosylceramide synthase and therapeutic methods using the same
CA3186766A1 (en) 2020-07-24 2022-01-27 Danielle Combessis Pharmaceutical compositions comprising venglustat

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB725226A (en) * 1952-06-03 1955-03-02 Berger Brothers Co Improvements in or relating to an inflatable surgical pad
GB725228A (en) * 1952-06-19 1955-03-02 Roche Products Ltd Substituted carbamic acid esters and process for the manufacture thereof
NL130759C (es) * 1965-10-07
DE4326510A1 (de) * 1993-08-06 1995-02-09 Bayer Ag Verfahren zur Herstellung von Cyclohexen-Derivaten
KR970701174A (ko) * 1994-02-10 1997-03-17 오노다 마사요시 신규한 카바메이트 유도체 및 이의 의약 조성물(Novel carbamate derivative and medicinal composition containing the same)
JPH08198751A (ja) * 1995-01-19 1996-08-06 Yamanouchi Pharmaceut Co Ltd カルバメート誘導体
SE9600683D0 (sv) * 1996-02-23 1996-02-23 Astra Ab Azabicyclic esters of carbamic acids useful in therapy
GB0400812D0 (en) 2004-01-14 2004-02-18 Celltech R&D Ltd Novel compounds
US8003617B2 (en) 2004-11-10 2011-08-23 Genzyme Corporation Methods of treating diabetes mellitus
JP5285643B2 (ja) * 2010-03-15 2013-09-11 シャープ株式会社 半導体集積回路および電子情報機器
PL2639234T3 (pl) 2010-11-12 2019-12-31 Shionogi & Co., Ltd. Krystaliczna pochodna morfinanu 6,7-nienasyconego-7-karbamoilu i sposób jej wytwarzania
RU2645675C2 (ru) * 2011-03-18 2018-02-27 Джензим Корпорейшн Ингибиторы глюкозилцерамид-синтазы
EP2723734A1 (en) 2011-06-22 2014-04-30 Isochem Process for the preparation of solifenacin and salts thereof
JP2013053228A (ja) * 2011-09-02 2013-03-21 Asahi Kasei E-Materials Corp エポキシ樹脂用硬化剤及びマイクロカプセル型エポキシ樹脂用硬化剤
JOP20130273B1 (ar) 2012-09-11 2021-08-17 Genzyme Corp مثبطات انزيم (سينثاز) غلوكوسيل سيراميد
KR20150130386A (ko) * 2013-03-15 2015-11-23 젠자임 코포레이션 글루코실세라마이드 신타아제 저해제의 제조 방법

Also Published As

Publication number Publication date
HUE064200T2 (hu) 2024-02-28
IL240617B (en) 2019-08-29
CN105189491A (zh) 2015-12-23
ES2968073T3 (es) 2024-05-07
CN108658970A (zh) 2018-10-16
JP2019167379A (ja) 2019-10-03
US10065949B2 (en) 2018-09-04
AR095436A1 (es) 2015-10-14
CA3092901A1 (en) 2014-09-25
ES2727869T3 (es) 2019-10-21
EP2970251B1 (en) 2019-02-27
HK1220689A1 (zh) 2017-05-12
TW201900625A (zh) 2019-01-01
US20200181137A1 (en) 2020-06-11
SG11201506415XA (en) 2015-09-29
TW201524974A (zh) 2015-07-01
EP3514157A1 (en) 2019-07-24
US10954230B2 (en) 2021-03-23
JP2016512838A (ja) 2016-05-09
JP6543242B2 (ja) 2019-07-10
TWI649317B (zh) 2019-02-01
SG10201706575UA (en) 2017-09-28
RU2015144035A3 (es) 2018-03-01
US20190031652A1 (en) 2019-01-31
BR112015020667A2 (pt) 2017-07-18
AU2014235132B2 (en) 2018-08-02
CA2906581C (en) 2022-09-20
AU2014235132A1 (en) 2015-09-24
RU2015144035A (ru) 2017-04-20
DK3514157T3 (da) 2023-11-27
UY35438A (es) 2014-10-31
IL259770A (en) 2018-07-31
CY1121859T1 (el) 2020-07-31
CA3092901C (en) 2024-01-02
IL240617A0 (en) 2015-10-29
IL259770B (en) 2020-04-30
MX2015012842A (es) 2016-02-03
JP6813626B2 (ja) 2021-01-13
WO2014151291A1 (en) 2014-09-25
EP3514157B1 (en) 2023-09-06
KR20150130386A (ko) 2015-11-23
HUE043394T2 (hu) 2019-08-28
US10604518B2 (en) 2020-03-31
CA2906581A1 (en) 2014-09-25
AU2019200350A1 (en) 2019-02-07
US20160039806A1 (en) 2016-02-11
US20170334903A1 (en) 2017-11-23
US9682975B2 (en) 2017-06-20
CN105189491B (zh) 2018-07-06
EP2970251A1 (en) 2016-01-20

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