UY35438A - Procedimiento para preparar inhibidores de la glucosilceramida sintasa. - Google Patents
Procedimiento para preparar inhibidores de la glucosilceramida sintasa.Info
- Publication number
- UY35438A UY35438A UY0001035438A UY35438A UY35438A UY 35438 A UY35438 A UY 35438A UY 0001035438 A UY0001035438 A UY 0001035438A UY 35438 A UY35438 A UY 35438A UY 35438 A UY35438 A UY 35438A
- Authority
- UY
- Uruguay
- Prior art keywords
- glucosilceramide
- sintasa
- procedure
- prepare inhibitors
- treatment
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Abstract
La invención se refiere a un procedimiento para preparar inhibidores de la glucosilceramida sintasa (GCS) útiles para el tratamiento de enfermedades metabólicas, tales como las tesaurismosis en el lisosoma, solas o en combinación con tratamiento enzimático de sustitución, y para el tratamiento del cáncer.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361791913P | 2013-03-15 | 2013-03-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UY35438A true UY35438A (es) | 2014-10-31 |
Family
ID=50543333
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UY0001035438A UY35438A (es) | 2013-03-15 | 2014-03-14 | Procedimiento para preparar inhibidores de la glucosilceramida sintasa. |
Country Status (21)
| Country | Link |
|---|---|
| US (4) | US9682975B2 (es) |
| EP (2) | EP2970251B1 (es) |
| JP (2) | JP6543242B2 (es) |
| KR (1) | KR20150130386A (es) |
| CN (2) | CN105189491B (es) |
| AR (1) | AR095436A1 (es) |
| AU (2) | AU2014235132B2 (es) |
| BR (1) | BR112015020667A2 (es) |
| CA (2) | CA3092901C (es) |
| CY (1) | CY1121859T1 (es) |
| DK (1) | DK3514157T3 (es) |
| ES (1) | ES2727869T3 (es) |
| HK (1) | HK1220689A1 (es) |
| HU (2) | HUE064200T2 (es) |
| IL (2) | IL240617B (es) |
| MX (1) | MX365464B (es) |
| RU (1) | RU2015144035A (es) |
| SG (2) | SG11201506415XA (es) |
| TW (2) | TW201900625A (es) |
| UY (1) | UY35438A (es) |
| WO (1) | WO2014151291A1 (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6543242B2 (ja) | 2013-03-15 | 2019-07-10 | ジェンザイム・コーポレーション | グルコシルセラミド合成酵素阻害剤の製造方法 |
| HUE054205T2 (hu) * | 2017-02-17 | 2021-08-30 | Univ Muenster Westfaelische Wilhelms | Elektrolit-adalékanyag lítium-ion akkumulátorokhoz |
| US20200339587A1 (en) | 2017-12-21 | 2020-10-29 | Lysosomal Therapeutics Inc. | Crystalline substituted cyclohexyl pyrazolo[1,5-a]pyrimidinyl carboxamide compound and therapeutic uses thereof |
| US10519157B2 (en) * | 2018-02-09 | 2019-12-31 | X-Cutag Therapeutics, Inc. | Deuterated compounds for treating Fabry, Gaucher, Parkinson's and related diseases and conditions, and compositions and methods thereof |
| US20230212123A1 (en) | 2020-04-28 | 2023-07-06 | The Regents Of The University Of Michigan | Pyridine Inhibitors of Glucosylceramide Synthase and Therapeutic Methods Using the Same |
| WO2022018695A1 (en) | 2020-07-24 | 2022-01-27 | Genzyme Corporation | Pharmaceutical compositions comprising venglustat |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB725226A (en) * | 1952-06-03 | 1955-03-02 | Berger Brothers Co | Improvements in or relating to an inflatable surgical pad |
| GB725228A (en) * | 1952-06-19 | 1955-03-02 | Roche Products Ltd | Substituted carbamic acid esters and process for the manufacture thereof |
| NL130759C (es) * | 1965-10-07 | |||
| DE4326510A1 (de) | 1993-08-06 | 1995-02-09 | Bayer Ag | Verfahren zur Herstellung von Cyclohexen-Derivaten |
| KR970701174A (ko) * | 1994-02-10 | 1997-03-17 | 오노다 마사요시 | 신규한 카바메이트 유도체 및 이의 의약 조성물(Novel carbamate derivative and medicinal composition containing the same) |
| JPH08198751A (ja) * | 1995-01-19 | 1996-08-06 | Yamanouchi Pharmaceut Co Ltd | カルバメート誘導体 |
| SE9600683D0 (sv) | 1996-02-23 | 1996-02-23 | Astra Ab | Azabicyclic esters of carbamic acids useful in therapy |
| GB0400812D0 (en) | 2004-01-14 | 2004-02-18 | Celltech R&D Ltd | Novel compounds |
| JP2008519840A (ja) | 2004-11-10 | 2008-06-12 | ジェンザイム・コーポレイション | 糖尿病の処置方法 |
| JP5285643B2 (ja) * | 2010-03-15 | 2013-09-11 | シャープ株式会社 | 半導体集積回路および電子情報機器 |
| JP5070364B2 (ja) | 2010-11-12 | 2012-11-14 | 塩野義製薬株式会社 | ６，７−不飽和−７−カルバモイルモルヒナン誘導体の結晶およびその製造方法 |
| MY173998A (en) * | 2011-03-18 | 2020-03-03 | Genzyme Corp | Glucosylceramide synthase inhibitors |
| CN103702997A (zh) | 2011-06-22 | 2014-04-02 | 伊索凯姆公司 | 索非那新及其盐的制备方法 |
| JP2013053228A (ja) * | 2011-09-02 | 2013-03-21 | Asahi Kasei E-Materials Corp | エポキシ樹脂用硬化剤及びマイクロカプセル型エポキシ樹脂用硬化剤 |
| MA37975B2 (fr) | 2012-09-11 | 2021-03-31 | Genzyme Corp | Inhibiteurs de synthase de glucosylcéramide |
| JP6543242B2 (ja) * | 2013-03-15 | 2019-07-10 | ジェンザイム・コーポレーション | グルコシルセラミド合成酵素阻害剤の製造方法 |
-
2014
- 2014-03-13 JP JP2016501840A patent/JP6543242B2/ja active Active
- 2014-03-13 CN CN201480026302.4A patent/CN105189491B/zh active Active
- 2014-03-13 CA CA3092901A patent/CA3092901C/en active Active
- 2014-03-13 KR KR1020157027836A patent/KR20150130386A/ko not_active Application Discontinuation
- 2014-03-13 HU HUE19153389A patent/HUE064200T2/hu unknown
- 2014-03-13 CN CN201810630738.4A patent/CN108658970A/zh active Pending
- 2014-03-13 BR BR112015020667A patent/BR112015020667A2/pt not_active Application Discontinuation
- 2014-03-13 AR ARP140100982A patent/AR095436A1/es unknown
- 2014-03-13 ES ES14718835T patent/ES2727869T3/es active Active
- 2014-03-13 TW TW107132577A patent/TW201900625A/zh unknown
- 2014-03-13 EP EP14718835.3A patent/EP2970251B1/en active Active
- 2014-03-13 MX MX2015012842A patent/MX365464B/es active IP Right Grant
- 2014-03-13 WO PCT/US2014/025384 patent/WO2014151291A1/en active Application Filing
- 2014-03-13 RU RU2015144035A patent/RU2015144035A/ru not_active Application Discontinuation
- 2014-03-13 TW TW103108899A patent/TWI649317B/zh not_active IP Right Cessation
- 2014-03-13 DK DK19153389.2T patent/DK3514157T3/da active
- 2014-03-13 US US14/776,443 patent/US9682975B2/en active Active
- 2014-03-13 SG SG11201506415XA patent/SG11201506415XA/en unknown
- 2014-03-13 EP EP19153389.2A patent/EP3514157B1/en active Active
- 2014-03-13 HU HUE14718835A patent/HUE043394T2/hu unknown
- 2014-03-13 AU AU2014235132A patent/AU2014235132B2/en not_active Ceased
- 2014-03-13 CA CA2906581A patent/CA2906581C/en active Active
- 2014-03-13 SG SG10201706575UA patent/SG10201706575UA/en unknown
- 2014-03-14 UY UY0001035438A patent/UY35438A/es not_active Application Discontinuation
-
2015
- 2015-08-17 IL IL240617A patent/IL240617B/en active IP Right Grant
-
2016
- 2016-07-20 HK HK16108676.6A patent/HK1220689A1/zh not_active IP Right Cessation
-
2017
- 2017-05-12 US US15/593,440 patent/US10065949B2/en active Active
-
2018
- 2018-06-03 IL IL259770A patent/IL259770B/en active IP Right Grant
- 2018-08-01 US US16/051,892 patent/US10604518B2/en active Active
-
2019
- 2019-01-18 AU AU2019200350A patent/AU2019200350A1/en not_active Abandoned
- 2019-05-27 CY CY20191100562T patent/CY1121859T1/el unknown
- 2019-06-13 JP JP2019109986A patent/JP6813626B2/ja active Active
-
2020
- 2020-02-14 US US16/791,854 patent/US10954230B2/en active Active
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 109 | Application deemed to be withdrawn |
Effective date: 20211112 |