KR900008742B1 - 핵산 서열의 증대 방법 - Google Patents

핵산 서열의 증대 방법 Download PDF

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KR900008742B1
KR900008742B1 KR1019860002332A KR860002332A KR900008742B1 KR 900008742 B1 KR900008742 B1 KR 900008742B1 KR 1019860002332 A KR1019860002332 A KR 1019860002332A KR 860002332 A KR860002332 A KR 860002332A KR 900008742 B1 KR900008742 B1 KR 900008742B1
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뱅크스 물리스 케리
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Abstract

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핵산 서열의 증대 방법
제1도는 증대시키려고 하는 인체 β-글로빈의 94개 염기쌍 서열을 나타낸 것이고, 겸상 적혈구 빈혈증(sickle cell anemia)과 관련된 단일 염기쌍의 변화는 94-머(94-mer) 아래에 표시되어 있다.
제2도는 인체의 야생형 DNA에 및 정상적인 β-글로빈 유전자의 1.9kb
Figure kpo00001
H I 단편을 함유하는 플라스미드(pBR 328 : HbA로 표기)에 함유되어 있는 94-머(mer)의 증대를 제시하는 폴리아크릴 아미드 겔 전기 영동의 자동방사선 사진다.
제3도는 pBR 328-HbA 및 β-글로빈의 겸상적혈구 대립인자(allele)의 1.9kb
Figure kpo00002
H I 단편을 함유하는 플라스미드(pBR 328 : HbS로 표기)[durlt에서, pBR 328 : HbA에서 증대되는 서열은
Figure kpo00003
II로 절단되지만, pBR 328 : HbS에 증대되는 서열은 동일한 처리를 하여도
Figure kpo00004
II로 절단되지 않는다]에 존재하는 어떤 특정의 표적 94-머 서열의 증대를 설명해주는 폴리아크릴아미드 겔 전기영동의 자동방사선 사진이다.
제4도는 인체 β-글로빈의 목적하는 94-머 서열의 증대를 위한 폴리머라제 연쇄 반응(polymerase chain reaction)의 단계 및 생성물을 2개의 올리고뉴클레오타이드 프라이머(oligonucleotide primers)를 사용하여 3개의 사이클로 상세하게 설명한 것이다.
제5도는 pBR 328 : HbA에서 240-머 서열의 4개의 사이클 후의 증대를 설명해주는, 폴리아크릴아미드겔 전기영동의 자동방사선 사진이다.[여기에서, 분취량(aliquots)은
Figure kpo00005
I(레인 3),
Figure kpo00006
II(레인 4) 또는
Figure kpo00007
f I(레인 5)로 분해시킨다]. 레인 1은 분자량 표준이고 레인 2는 무상(intact) 240-bp 생성물을 함유한다.
제6도는
Figure kpo00008
I 및
Figure kpo00009
f I 제한부의 범위에서 정상적인 β-글로빈 유전자(βA) 및 경상 적혈구 세포의 β-글로빈 유전자(βs)의 서열을 보여준다. [여기에서, βA에 있어 외줄은
Figure kpo00010
I 부위(CTGAG)의 위치를 나타내고 βA 및 βS에 있어 겹줄은 Hinf I 부위(GACTC)의 위치를 나타낸다].
제7도는 정상적인 β-글로빈을 40-어탐침을 사용하여 먼저
Figure kpo00011
I 제한효소 및 이어서
Figure kpo00012
f I 제한효소로 연속적으로 분해시킨 결과를 설명한 것이다.
제8도는 경상적혈구 β-글로빈을 제7도에서와 동일한 40-머 탐침을 사용하여 먼저
Figure kpo00013
I 제한효소 및 이어서
Figure kpo00014
f I 제한효소로 연속적으로 분해시킨 결과를 설명한 것이다.
제9도는 본 발명에 의해 증대시킨 전 인체 DNA의 샘플에 베타-글로빈 대립인자가 존재함을 특징으로 하는 제7도에서와 동일한 40-머 탐침의 용도를 설명하기 위한 폴리아크릴아미드 겔 전기영동의 자동방사선 사진이다.
제10도는 에티디움 브로마이드 및 UV 광을 사용하여 가시화한 6% 누시이브 아가로오스 겔(Nusieve agarose gel)의 사진이다. 이 사진은 110-bp 증대 생성물의 아단편의 증대[여기에서, 아단편은 110-bp 단편 이내에서 내부에 존재하는 세트(inner nested set)이다]를 설명한 것이다.
본 발명은 현존하는 핵산 서열을 증대시키는 방법에 관한 것이다. 특히 본 발명은 주어진 DNA 또는 RNA의 서열로부터 특정 서열을 초기에 존재하는 양과 비해서 다량으로 생산하는 방법에 관한 것이다. DNA 또는 RNA는 일본쇄 또는 이본쇄 일 수 있으며, 비교적 순수한 종 또는 핵산 혼합물의 성분일 수 있다. 본 발명의 방법을 목적하는 핵산 서열의 증대를 달성하기 위한 반복 반응에 이용한다.
특히 진단적 적용(diagnoistic application)을 위해 표적의 핵산 서열은 해당 DNA 또는 RNA의 단지 소부분(small portion)일 수 있으며, 이 경우 비동위적으로 표지(nonisotopically labeled)하거나 말단을 표지한 (end-labeled)올리고뉴클레오타이드 탐침을 사용하여 그의 존재를 탐지하는 것이 어려울 수도 있다. 탐침 탐지 시스템의 민감도(sensitivity)를 증진시키는데에는 상당한 노력이 소요되지만, 통상적으로 이용가능한 방법을 사용하여 용이하게 충분히 탐지 가능한 것이 다량 존재하므로 표적의 서열을 증대시킴에 관한 연구가 거의 이루어지지 않았다.
현존하는 서열로부터 또는 새로이(de novo) 핵산을 합성하는 여러 가지 방법이 문헌에 기술되어 있다. 이들 방법은 완전히 특성을 부여한 서열의 주어진 핵산을 다량으로 제조함을 가능하게 한다.
새로이 핵산을 합성하는 한 알려진 방법에는 뉴클레오사이드(nucleoside) 유도체로부터 핵산을 유기적으로 합성하는 방법이 포함된다. 이 합성법은 용액에서 또는 고체 지지체 상에서 수행할 수 있다. 유기 합성법의 한 형태로 포스포트리에스테르 방법(phosphotriester method)이 있는데, 이 방법은 유전자 단편 또는 짧은 유전자를 제조하는데 이용된다. 포스포트리에스테르 방법에서, 올리고뉴클레오타이드 들은 제조된 다음 함께 연결되어 더 긴 핵산을 형성할 수 있다. 이 방법의 상세한 설명은 하기 문허[Narany S. A., et al.,
Figure kpo00015
.,
Figure kpo00016
, 90(1979)] 및 미합중국 특허 제4,356,270호에 기술되어 있다. 이 특허에는 소마토스타틴 유전자(someatostatin gene)의 합성 및 클로닝(cloning)에 관한 내용이 기술되어 있다.
유기 합성법의 두 번째 형태로는 포스포디에스테르방법(phosphodiester method)이 있는데, 이 방법은 tRNA 유전자를 제조하는데 이용된다. 이 방법의 상세한 설명은 하기 문헌(Brown. E. L., et al.,
Figure kpo00017
.,
Figure kpo00018
, 109(1979)]에 기술되어 있다. 포스포트리에스테르 방법에서와 마찬가지로 포스포디에스테르방법에는, 결과적으로 함께 연결되어 목적하는 핵산을 형성하는 올리고클레오타이드의 합성법이 포함된다.
상기의 드 노보 합성법(de novo synthesis)들이 장쇄 핵산의 합성에 이용될 수는 있지만, 이들 방법은 다량의 핵산 합성에 매우 실용적으로 사용되지는 않는다. 상기의 방법은 힘이 들고 시약을 소비하여, 값비싼 장비와 시약을 필요로 하며, 총괄 효율(overall efficiency)이 낮다. 낮은 총괄 효율은 올리고뉴클레오타이드의 합성 및 연결 반응의 비효율에 의해 야기될 수 있다. 긴 핵산을 합성함에 있어, 또는 심지어 더 짧은 핵산을 다량 합성함에 있어, 많은 올리고뉴클레오타이드가 합성되는데 필요하며 많은 연결 반응이 요구되리라고 생각된다. 결과적으로, 이들 방법들은 어떤 목적하는 핵산을 다량 합성하는데에는 실용적이지 못할 것이다.
초기에 존재하는 소량의 핵산으로부터 다량의 핵산을 제조하는 방법들도 또한 있다. 이들 방법에는 적절한 숙주 시스템에서 핵산을 클로닝시키는 방법이 포함되는데, 이 방법에서는 목적하는 핵산은, 숙주를 형질전환시키는데 사용되는 적절한 백터내로 삽입시킨다. 숙주를 배양하는 경우 벡터는 복제되므로, 목적하는 핵산을 더 많은 복제본으로 제조한다. 핵산 단편을 아클로닝시킴에 관한 간단한 설명은 하기 문헌[Maniatis, T.m, et al.,
Figure kpo00019
., Cold Spring Harbor Laboratory PP. 390-401(1982)]에 기술되어 있다. 또한 이에 관련된 기술(techniques)은 미합중국 특허 제 4,416,988호 및 제 4,403,036호에 기술되어 있다.
핵산을 합성하는 세 번째 방법은, 미합중국 특허 제 4,293,652호에 기술되어 있으며, 상기 기술한 유기 합성의 하이브리드 및 분자 클로닝 방법이다. 이 방법에서 목적하는 핵산 서열을 구성하는 올리고뉴클레오타이드의 적절한 수는 유기적으로 합성하여, 각각 후속의 삽입과정전에 성장에 의해 증대되는 벡터내로 연속적으로 삽입한다.
본 발명은 분자의 클로닝 방법과 약간 유사한 점을 내포하고 있다 : 하지만, 본 발명은 특정 유기체의 증식(propagation)은 포함하지 않으므로 본 발명에 수반되는 가능한 위험 또는 불편한 점을 피하고 있다. 본 발명은 또한 목적하는 서열에 관련되지 않은 핵산 서열의 합성을 필요로 하지 않으므로, 본 발명은 복잡한 생물학적 혼합물로부터의 생성물의 값비싼 정제 과정의 필요를 미연에 방지한다.
본 발명은 핵산 및 이의 혼합물에 존재하는 하나 이상의 특정한 핵산 서열을 프라이머 및 유도제를 사용하여 증대시키는 방법이다. 1개의 프라이머의 증대 생성물은, 다른 것과 하이브리드화되는 경우, 목적하는 특정의 핵산 서열의 생산을 위한 주형(template)이 되며, 역으로, 과정은 서열의 목적하는 양을 생산하는 데 필요한 만큼 자주 반복할 수 있다. 이 방법은 표적의 서열로부터 핵산을 다량 생산함에 대해 상기 기술한 방법들보다 더욱 효율적이라고 기대되며 비교적 단기간에 그러한 핵산을 생산하리라고 기대된다. 본 발명의 희귀 종 핵산의 효과적인 탐지를 위해 핵산 혼합물중에 존재하는 그러한 희귀 종의 핵산을 증대시키는 데 특히 효과적이다.
더욱 상세히 설명하자면, 본 발명은 하기 단계들로 이루어짐을 특징으로하여, 핵산 또는 핵산의 혼합물을 함유하는 적어도 하나의 특정의 핵산 서열을 증대시키는 방법을 제공하며, 여기에서 각 핵산은 같거나 또는 다른 길이의 두 개의 상보적인 서열로 구성되어 있다.
(a) 각각 다른 특명 서열을 증대시키기 위해, 각 프라이머의 증대 생성물이 각 핵산 본쇄에 상보적으로 합성되는 조건하에서 본쇄들을 2개의 프라이머로 처리하며, 여기에서 상기의 트라이머 또는 프라이머들은 1개의 프라이머로부터 합성된 증대 생성물이, 그의 상보서열(complement)로부터 분리되는 경우, 다른 프라이머의 증대 생성물의 합성을 위해 주형으로 제공될 수 있도록 감각의 특정 서열의 각 본쇄에 실질적으로 상보되도록 선택된다 : (b) 프라이머 증대 생성물을, 그들이 합성된 주형으로부터 분리시켜 일본쇄 분자를 제조하고 : (c) 단계 (b)로부터 생산한 일본쇄 문자를 프라이머 증대 생성물이 단계(b)에서 제조된 일본쇄 각각을 주형으로 사용하여 합성되는 조건하에 단계(a)의 프라이머로 처리한다.
단계들은 연속적으로 또는 동시에 수행한다. 게다가 단계 (b) 및 (c)는 서열이 목적하는 수준까지 증대될 때까지 반복할 수 있다.
본 발명은 현존하는 완전히 특이한 서열의 핵산을 다량으로 제조하는데 뿐만 아니라 있기는 하나 완전히 특이하지 않은 핵산 서열을 제조하는데 있어 유용할 수 있다. 각각의 경우에 증대시킬 서열의 초기 복제본은, 비록 순수하거나 또는 분리된 분자일 필요는 없더라도 수득할 수 있어야만 한다.
본 명세서에서 프라이머, 탐침, 탐지될 올리고머 단편, 올리고머 조절자 및 표지하지 않은 블로킹 올리고머(unlabeled blocking oligomer)에 관하여 사용된 "올리고뉴클레오타이드(oligonucleotide)"는 데옥시리브 뉴클레오타이드 또는 리보뉴클레오타이드 2개 이상, 바람직하게는 3개 이상으로 이루어진 분자로 정의된다. 그의 정확한 크기는 여러 가지의 인자(factors)에 따라 다르며, 이는 올리고뉴클레오타이드의 궁극적인 작용 또는 용도에 따라 다른 것이다.
본 명세서에 사용된 "프라이머(primer)"는 정제된 반응 분해물에서 자연적으로 발생하든 또는 합성적으로 제조하던, 핵산 본쇄에 상보적인 프라이머 증대생성물의 합성이 야기될 수 있는 조건하, 즉 적절한 온도 및 pH에서 뉴클레오타이드, 및 DNA 폴리머라제와 같은 유도체 존재하에 놓여지는 경우 합성의 시발점으로 작용할 수 있는 올리고뉴클레오타이드에 관한 것이다. 프라이머는 증대시 최대 효율을 위해서 바람직하게는 일본쇄이나, 이본쇄일 수도 있다. 이본쇄인 경우, 프라이머는 증대 생성물을 제조하기 위해 사용되기 전에 먼저 그의 본쇄들로 분리시킨다. 바람직하게는, 프라이머는 올리고데옥시리보뉴클레오타이드이다. 프라이머는 유도제 존재하여 증대 생성물의 합성을 준비하기 위해서는 충분히 길어여만 한다. 프라이머들의 정확한 길이는 온도 및 프라이머 원(source of primer)을 포함한, 여러 가지 인자에 따라 다를 것이다. 예를들면, 표적 서열의 복잡성에 따라, 올리고뉴클레오타이드 프라이머는 비록 올리고뉴클레오타이드를 거의 함유하지 않을지라도, 전형적으로 15-25 또는 그 이상의 올리고뉴클레오타이드를 함유한다. 짧은 프라이머 분자는 통상적으로 주형과 함께 충분히 안정한 하이브리드복합물을 형성하기 위해서 더 차가운 온도를 요구한다.
본 명세서에서 프라이머들은 증대시킬 각 특정서열의 상이한 본쇄에 "상당히(substanitally)"상보되도록 선택된다. 이것은 프라이머들이 그들 각자의 본쇄들과 하이트리드화하기 위해서 상보적이어야 한다는 것을 의미한다. 그러므로, 프라이머 서열은 주형의 정확한 서열을 반영할 필요가 없다. 예를들면, 비-상보적은 뉴클레오타이드 단편은, 본쇄에 상보적인 프라이머 서열의 나머지와 함께, 프라이머 5'말단에 결합될 수 있다. 또한 비-상보적인 염기 또는 더 긴 서열을 프라이머내로 산개시킬 수 있는데, 단, 프라이머 서열은 그와 함께 하이브리드화 하기 위해 증대될 본래의 서열과 충분한 상보성을 가지며, 그러므로 다른 프라이머의 증대 생성물의 합성을 위해 주형을 형성한다.
본 명세서에 사용된 바대로, "제한 엔도뉴클레아제(restriction endonucleases)" 및 "제한효소(restrictionenzymes)"는 각각 특성의 뉴틀레오타이드 서열에서 또는 서열 근처에서 이본쇄 DNA를 절단하는 세균효소에 관한 것이다.
본 명세서에 사용된 바대로, "DNA 다형현상(polymorphism)"은 2개, 이상의 상이한 뉴클레오타이드 서열들이 DNA에서 특정 부위에 존재할 수 있는 상태에 관한 것이다.
"제한 단편 길이 다형현상(RFLP)"은 특정의 제한 엔도뉴클레아제로 분해시킴에 의해 형성된 제한 단편들의 길이에서 각각 사이의 차이에 관한 것이다.
본 발명은 직접적으로는 핵산에서 발견되는 하나 이상의 목적으로 특정 핵산 서열을 증대시키는 방법에 관한 것이다. 다량의 특정 서열이 본 발명에 의해 생성될 수 있으므로, 본 발명은 DNA 또는 mRNA의 클로닝효율을 증대시키기 위해, 및 표적서열의 탐지를 용이하게 하기 위해 이 표적서열을 증대시키기 위해 사용될 수 있다.
일반적으로 본 방법은 (a) 요구되는 서열의 말단이 올리고뉴클레오타이드가 합성되어 그들과 하이브리드화될 정도로 충분히 공지되고, (b) 소량의 서열이 연쇄 반응을 개시할 수 있도록 주어진, 1개 이상의 특정핵산 서열을 반응 단계에 포함된 수와 비교해서 지수적인 양으로 제조하기 위한 연쇄 반응을 포함한다. 연쇄 반응의 산물은 사용한 특정 프라이머의 말단에 상응하는 말단을 가진 분리된 핵산 이본쇄일 것이다.
어느 핵산원이건 정체되거나 또는 정제되지 않은 상태로 출발 핵산 또는 핵산들로서 사용하여, 목적하는 특정 핵산 서열을 함유하게 하거나 아마 함유하게 할 수 있다. 따라서 본 발명은, 예를들면 일본쇄 또는 이본쇄 일 수 있는 DNA 똔느 RNA와 전령 RNA를 사용할 수 있다. 게다가 각각의 일본쇄를 함유하는 DNA-RNA 하이브리드를 사용할 수 있다. 이들 핵산의 어느 혼합물도 사용할 수 있으며, 또는 본문에서 동일 또는 상이한 프라이머를 사용하는 선행 증대 반응으로부터 제조한 핵산을 사용할 수도 있다. 증대시킬 특정 핵산 서열은 단지 큰 분자의 단편일 수 있거나, 또는 초기에 분리된 분자로서 존재할 수 있어 특정 서열의 전체 핵산을 구성하고 있다. 증대될 서열이 초기에 순수한 형태로 존재할 필요는 없고 : 유기체가 특정생물학적 샘플의 단지 아주 작은 부분을 구성하는 특정 미생물로 인해 핵산 서열의 일부 또는 전 인체 DNA에 포함된 β-글로빈 유전자 부분과 같이, 복합 혼합물의 소부분일 수 있다. 출발 핵산은 동일 또는 상이한 목적하는 특정 핵산 서열을 하나이상 함유할 수 있다. 그러므로 본 발명은 1개의 특정 핵산 서열을 다량으로 제조하는데 뿐만 아니라 동일 또는 상이한 핵산 분자상에 위치한 상이한 특정핵산 서열을 1개 이상 동시에 증대시키는데 유용하다.
핵산 또는 핵산들은 어느 원천, 예를들면, pBR 322와 같은 플라스미드, 클론된 DNA 또는 RNA 또는 세균, 효모, 비루스 및 식물 또는 동물과 같은 고등생물을 포함한 어떤 원천의 자연 DNA 또는 RNA로부터 수득할 수 있다. NDA 또는 RNA는 혈액, 융몸모막의 융모(chorionic villi) 또는 양수 세포(ammiotic cells)와 같은 조직 물질로부터 하기 문헌[Maniatis et al., Molecular Cllning(1982), 280-281]에 기술되어 있는 여러 가지 기술에 의해 추출할 수 있다.
어느 특정 핵산 서열도 본 발명에 의해 제조할 수 있다. 단지 서열의 양말단에 있는 충분한 수의 염기가 상세히 알려져 있어 2개의 올리고뉴클레오타이드 프라이머를 목적하는 서열의 다른 분쇄에 서열중의 상대위치에서 하이브리드화하도록 제조할 수 있고, 1개의 프라이머로부터 합성된 증대 생성물이 그의 주형(상보서열)으로부터 분리될 경우, 한정된 길이의 핵산으로 기타의 프라이머를 증대시키기 위한 주형으로 기여할 수 있으면 된다. 서열의 양단면에 있는 염기에 관한 지식이 많으면 많을수록 표적핵산 서열용 프라이머의 특이성이 크고, 따라서 본 발명의 효율도 높아진다. 이 후 사용되는 단어, 프라이머는 특히 증대시킬 단편의 종료 서열(들)에 관한 정보에서 다소 모호한 경우 프라이머 1개 이상을 가리킨다. 예를들면, 단백질 서열 정보로부터 핵산 서열을 추론하는 경우 유전 코드의 축퇴성(degeneracy)을 기본으로 하여 모든 가능한 코돈 변이형을 나타내는 서열을 함유하는 프라이머의 집합이 각 본쇄에 사용될 것이다. 이 집합으로부터의 1개 프라이머는 증대시킬 목적 서열의 말단과 100% 동일할 것이다.
올리고뉴클레오타이드 프라이머는 어느 적합한 방법 예를들면, 상술한 포스토트리에스테르 및 포스포디에스테르방법, 또는 그의 자동조작되는 태양과 같은 방법을 사용하여 제조할 수 있다. 그와 같이 자동조작되는 한 태양에서 디에틸 포스포아미디트가 출발 물질로서 사용되며 하기 문헌[Beaucage et al.,
Figure kpo00020
(1981), 22 : 1859 - 1862]에 기술된 바대로 합성할 수 있다. 개질된 고체 지지대상에서 올리고뉴클레오타이드를 합성하는 한 방법이 미합중국 특허 제4,458,067호에 기술되어 있다. 생물학적 원천으로부터 분리한 프라이머(제한 엔도뉴클레아제와 같은)를 사용할 수도 있다.
특정 핵산 서열은 그 서열을 함유하는 핵산을 주형으로 사용해서 제조한다. 만일 핵산이 이본쇄를 함유하는 경우, 주형으로 사용하기 전에 프라이머 증대 생성물의 합성과 분리단계로서 또는 동시에 핵산의 본쇄를 분리시킬 필요가 있다. 이 본쇄 분리는 물리적, 화학적 또는 효소적 방법을 포함하는 적당한 방법으로 수행할 수 있다. 핵산의 본쇄를 분리시키는 한가지 물리적 방법이 핵산이 완전히(＞99%) 변성될 때까지 가열시키는 것이다. 전형적인 열 변성은 약 80 내지 105℃ 범위의 온도에서 약 1 내지 10분 범위의 시간이다. 본쇄 분리는 또한 헬리카제(helicase) 활성을 갖고 리보 ATP의 존재하에서 DNA를 변성시키는 것으로 알려져 있는 RecA 또는 헬리카제로서 공지되어 있는 효소군으로부터의 효소에 의해 효소할 수 있다. 헬리카제로 핵산의 본쇄를 분리하는데 적합한 반응 조건은 하기 문헌[kuhn Hoffmann-Berling,
Figure kpo00021
Figure kpo00022
, 43 : 63 (1978)]에 기술되어 있고, RecA를 사용하는 기술은 하기 문헌[C.Radding,
Figure kpo00023
: 405-37(1982)]에 시사되어 있다.
증대시킬 서열은 함유하는 원형 핵산이 일본쇄인 경우, 그의 상보서열은 거기에 1 또는 2개의 올리고뉴클레오타이드 프라이머를 가하여 합성한다. 적절한 단일 프라이머를 가하면, 프라이머 증대 생성물이 프라이머, 합성의 유도체 또는 촉매 및 하기에 기술된 4가지 뉴클레오타이드의 존재하에 합성된다. 생성물은 일본쇄 핵산에 부분적으로 상보적이며, 핵산 본쇄와 하이브리드화하여 상이한 길이의 이본쇄를 형성하고, 이어서 상술한 바와같이 일본쇄로 분리되어 2개의 분리된 상보적 일본쇄를 산출할 것이다. 또한 2개의 적당한 프라이머를 일본쇄 핵산에 가하여 반응을 수행할 수도 있다.
원형 핵산이 증대시킬 서열을 구성하고 있는 경우, 생성된 프라이머 증대 생성물(들)은 원형 핵산의 본쇄에 완전히 상보적이어서 서로 하이브리드화되며 일본쇄 분자로 분리될 동일한 길이의 이본쇄를 형성할 것이다.
핵산이 본래 이본쇄이거나 일본쇄이거나 핵산 또는 핵산들의 상보적인 본쇄들이 분리되면, 본쇄는 부가적인 핵산 본래의 합성을 위한 주형으로서 사용하기가 용이하다. 이 합성은 적당한 방법을 사용하여 수행한다. 통상 합성은 바람직하게는 pH 7-9 더욱 바람직하게는 약 8인 완충 수용액에서 수행한다. 바람직하게는 2개의 올리고뉴클레오타이드 프라이머의 물과량(클론된 핵산에 대해서는 통상 프라이머 : 주형이 약 1000 : 1, 게놀의 핵산에 대해서는 통상 프라이머 : 주형이 약 106: 1)을 분리된 주형 본쇄가 함유된 완충액에 가한다. 그러나 본 발명을 감별 적용에 사용하는 경우, 상보적인 본쇄의 양을 알 수가 없어 상보적인 본쇄의 양에 대한 프라이머의 양을 정확히 측정할 수 없다. 하지만 실용적인 문제로서 통상 가해지는 프라이머의 양은 증대시킬 서열이 복잡한 장쇄 핵산 본쇄의 혼합물에 함유되어 있는 경우 상보적인 본쇄(주형)의 몰과량일 것이다. 큰 물과량은 큰 몰과량은 방법의 효율을 증진시키는데 바람직하다.
데옥시리보뉴클레오타이드 트리포스페이트 dATP, dCTP, dGTP 및 TTP도 적량을 합성 혼합물에 가하고, 생성된 용액을 약 90 내지 100℃로 약 1내지 10분, 바람직하게는 1 내지 4분동안 가열한다. 이 가열기간이후 용액을 플라이머 하이브리드화에 바람직한 실온으로 냉각한다. 냉각된 혼합물에 프라이머 증대 반응을 유도 또는 촉매(여기서는 "유도체"라 칭함)하는 적당한 제제를 가하고, 당분야에 공지된 조건하에 반응을 수행한다. 이 합성 반응은 실온 내지 유도제가 더 이상 효율적으로 반응하지 못하는 온도 이상까지에서 수행할 수 있다. 따라서 예를들면, DNA 폴리머라제를 유도제로 사용한 경우 온도는 통상 약 40℃보다 높지 않다. 가장 편리하게는 실온에서 반응시킨다.
유도제는 효소를 포함하여 프라이머 증대 생성물의 합성을 수행하는 특성 화합물 또는 시스템일 수 있다. 이 목적에 적합한 효소는, 예를들면,
Figure kpo00024
DNA 폴리머라제, I.
Figure kpo00025
DNA 폴리머라제 I의 클레노우 단편, T4DNA 폴리머라제, 기타 가능한 DNA 폴리머라제, 역전사 효소 및 내열성 효소를 포함한여 적당한 방식으로 뉴클레오타이드를 배합하여 각 핵산 본쇄에 상보적인 프라이머 증대 생성물을 형성하는 기타 효소 등이다. 일반적으로 합성은 각 프라이머의 3'말단에서 개시하여 합성이 종료될 때까지 주형 본쇄를 따라 5' 방향으로 진행하며, 상이한 길이의 분자를 제조한다. 그러나 상술한 동일 방법을 사용하여 5'말단에서 합성을 개시하고 다른 방향으로 진행하는 유도제도 있을 수 있다.
새로 합성된 본쇄 및 그에 상보적인 핵산 본쇄는 이본쇄 분자를 형성하여 본 발명의 연속 단계에 사용된다. 다음 단계에서 이본쇄 분자의 본쇄는 상술한 특정 방법을 사용 분리하여 일본쇄 분자를 제공한다.
새로운 핵산은 일본쇄 분자상에서 합성된다. 반응을 진행시키는데 필요하면 부가적인 유도제, 뉴클레오타이드 및 프라이머를 상술한 조건하에 첨가할 수 있다. 역시 합성은 올리고뉴클레오타이드 프라이머의 한쪽 말단에서 개시하고 주형의 일본쇄를 따라 진행하여 부가적인 핵산을 생성한다. 이 단계후, 증대 생성물의 반이 두 프라이머에 의해 결합된 특정핵산 서열을 구성한다.
본쇄 분리 및 증대 생성물 합성의 단계는 특성 핵산 서열의 목적하는 양을 생산하기 위해 필요한 만큼 자주 반복할 수 있다. 계속 하기에 상세히 설명하겠지만, 생성된 특정 핵산 서열의 양은 지수적 양상으로 축적된다.
첫 번째 핵산 또는 핵산의 혼합물로부터 한가지 이상의 특정 핵산 서열을 제조하려고 할 때는 상이한 올리고뉴클레오타이드 프라이머의 적정한 수를 사용한다. 예를들면 2개의 상이한 특정 핵산 서열을 제조할 경우 4개의 프아미어가 사용된다. 프라이머중 2개는 특정 핵산 서열의 하나에 대해 특이하고, 다른 2개의 프라이머는 두 번째 특정 핵산 서열에 대해 특이하다. 이런 식으로 2개의 상이한 특정 서열의 각각을 본 발명에 의해 지수적으로 생산할 수 있다.
본 발명은 각 단계후에 새로운 시약을 가하거나 동시에 가하는 방법, 모든 시약을 개시 단계에 가하거나, 부분씩 단계적으로 및 부분씩 동시에 가하는 방법, 모든 시약을 개시 단계에 가하거나, 부분씩 단계적으로 및 부분씩 동시에 가하는 방법, 신선한 시약을 주어진 모든 단계후에 가하는 방법등 단계적 방법으로 수행할 수 있다.
만약 열에 약한 효소의 경우에, 열과 같은 분쇄 분리 방법을 사용하여 유도체를 불활성화시킨다면, 이어서 매 분쇄 분리 단계 이후 유도제를 보충시킬 필요가 있다. 동시 방법은 효소적 수단을 본래 분리 단계에 이용한 경우 사용할 수 있다. 동시적 방법에서 반응 혼합물은 목적하는 서열을 함유하는 핵산 본쇄(들)의 예, 분쇄-분리 효소(예 : 헬리카제), ATP와 같이 적당한 본쇄-분리효소용 에너지원, 4개의 뉴클레오타이드, 과량의 올리고뉴클레오타이드 프라이머, 및 예를들어
Figure kpo00026
DNA 폴리머라제 1의 클로노우 단편과 같은 유도제를 함유한다. 동시적 방법에서 변성시 열을 사용한 경우, 열안정성 폴리미라제와 같은 내열과 같은 유도제를 함유한다. 동시적 방법에서 변성시 열을 사용한 경우, 열안정성 폴리머라제와 같은 내열성 유도제를 사용하여 상승온도에서, 바람직하게는 유도제에 따라 65-90℃에서 조작하며, 이 온도에서 핵산은 일본쇄와 이본쇄를 동등하게 구성한다. 길이가 짧은 핵산을 위해서는 약 50℃의 낮은 온도를 사용한다. 그 이상의 온도는 효소가 분해하는 온도 또는 프라이머 하이브리드화가 불충분한 수준으로 일어나는 온도 이상에 의존한다. 그런 내열성 효소는 예를들면 하기 문헌[A. S. Kaledin et al,
Figure kpo00027
, 644-651(1980)]에 기술되어 있다. 방법의 각 단계는 개시에서의 모든 시약의 존재에도 불구하고 연속해서 일어난다. 가외의 물질을 필요에 따라 가할 수 있다. 적당한 시간이 경과하여 특정 핵산 서열의 목적하는 양이 생성된 후, 공지된 방법으로 효소를 불활성화하거나 반응의 성분을 분리함으로써 반응을 정지시킬 수 있다.
본 발명의 방법은 계속적으로 수행할 수 있다. 자동조작되는 방법의 한 태양에서, 반응은 변성 부위, 시약 첨가 부위, 반응 부위를 통해 순환한다. 다른 태양에서 프라이머 증대 생성물의 합성시 사용되는 효소를 컬럼에 고정시킬 수 있다. 기타 반응 성분은 펌프에 의해서 컬럼과 일련의 가열 코일을 통해 순환되며 따라서 생성된 핵산이 효소의 불활성화 없이 반복해서 변성될 수 있다.
본 발명은 상보적인 본쇄 [S+] 및 [S-]으로 구성된 목적 서열[S]를 함유하는 이본쇄 DNA를 핵산으로 사용하여 하기에 도식적으로 설명되고 있다. 첫 번째 및 매 후속적 반응 사이클도중 원형 주형상에 각 올리고뉴클레오타이드 프라이머의 증대는 단지 1개의 프라이머로 종료하는 무한한 걸이의 새로운 ssDNA분자 생성물을 생성할 것이다. 이후 생성물은 "긴(long) 생성물"이라 칭하며, 선상으로 축적할 것이다 : 즉 어느 사이클수 이후에 존재하는 양은 사이클 수에 비례한다.
생성된 긴 생성물 후속 사이클중에서 하나의 또는 다른 올리고뉴클레오타이드 프라이머용 주형으로 작용하여 목적하는 서열 [S+] 또는 [S-]분자를 생성한다. 이 분자들은 또한 하나의 또는 다른 올리고뉴클레오타이드 프라이머용 주형으로 작용하여 그밖의 [S+] 및 [S-]를 생성하고, 다라서 연쇄 반응이 유지되며, 결과적으로, 사이클의 수화 비교해서 지수적 비율로 [S]의 축적을 초래한다.
의도한 것들외에 올리고뉴클레오타이드 하이브리드화에 의해 형성된 부산물은 자기-촉매적이지 못하며 (소수의 경우는 제외) 따라서 선상 비율로 축적한다.
증대시킬 특정 서열, [S]는 다음과 같이 도식적으로 인용할 수 있다 :
[S+] 5' AAAAAAAAAAXXXXXXXXXXCCCCCCCCCC 3'
[S-] 3' TTTTTTTTTTYYYYYYYYYYGGGGGGGGGG 5'
적당한 올리고뉴클레오타이드 프라이머는 다음과 같다.
프라이머 1 : GGGGGGGGGG
프라이머 2 : AAAAAAAAAA
그래서 만일 [S]를 함유하는 DNA
.....zzzzzzzzzzzzzzzAAAAAAAAAAXXXXXXXXXXCCCCCCCCCCzzzzzzzzzzzzzzzz.....
.....zzzzzzzzzzzzzzzzTTTTTTTTTTYYYYYYYYYYGGGGGGGGGGzzzzzzzzzzzzzzzz.....
이 일본쇄로 분리되고 그의 일본쇄가 프라이머 1과 2에 하이브리드화되면, 하기 증대 반응이 4개의 데옥시리보 뉴클레오사이드 트리포스페이트의 존재하여 DNA 폴리머라제에 의해 촉매될 수 있다 :
Figure kpo00028
.....zzzzzzzzzzzzzzzzAAAAAAAAAAXXXXXXXXXXCCCCCCCCCCzzzzzzzzzzzzzzzzz......
원형 주형 본체+
원형 주형 본체-
.....zzzzzzzzzzzzzzzzzTTTTTTTTTTYYYYYYYYYYGGGGGGGGGGzzzzzzzzzzzzzzzzz.....
Figure kpo00029
형성된 2개의 이본쇄의 변성시, 생성물은 다음과 같다 :
3'.....zzzzzzzzzzzzzzTTTTTTTTTTTYYYYYYYYYYGGGGGGGGGG 5'
새로 합성된 긴 생성물 1
5'.....zzzzzzzzzzzzzzAAAAAAAAAAAXXXXXXXXXXCCCCCCCCCCzzzzzzzzzzzzzz.....3'
원형 주형 본체+
3'.....zzzzzzzzzzzzzzTTTTTTTTTTYYYYYYYYYYGGGGGGGGGGzzzzzzzzzzzzzz.....5'
원형 주형 본체-
5'AAAAAAAAAAAXXXXXXXXXXCCCCCCCCCCzzzzzzzzzzzzzz...3'
새로 합성된 긴 생성물 2
이들 4개의 본쇄를 다음 사이클에서 프라이머 1 및 2와 하이브리드화시킬 경우, 유도체는 하기 반응을 촉매한다.
프라이머2
Figure kpo00030
이 방향으로 증대
3'.....zzzzzzzzzzzzzzTTTTTTTTTTYYYYYYYYYYGGGGGGGGGG 5'
새로 합성된 긴 생성물 1
증대
Figure kpo00031
프라이머 1
5'.....zzzzzzzzzzzzzzAAAAAAAAAAXXXXXXXXXXCCCCCCCCCCzzzzzzzzzzzzzz..... 3'
원형 주형 본체+
프라이머 2
Figure kpo00032
증대
3'......zzzzzzzzzzzzzzTTTTTTTTTTYYYYYYYYYYGGGGGGGGGGzzzzzzzzzzzzzz..... 5'
원형 주형 본쇄+
이 방향으로 증대
Figure kpo00033
GGGGGGGGGG 5' 프라이머 1
5'AAAAAAAAAAXXXXXXXXXXCCCCCCCCCCzzzzzzzzzzzzzz...... 3'
상기 4개의 이본쇄가 분리되면, 하기 본쇄가 된다 :
5' AAAAAAAAAAXXXXXXXXXXCCCCCCCCCC 3'
새로 합성된 [S+]
3'......zzzzzzzzzzTTTTTTTTTTYYYYYYYYYYGGGGGGGGGG 5'
첫번째 사이클에서 합성된 생성물 1
3'......zzzzzzzzzzzzzzTTTTTTTTTTYYYYYYYYYYGGGGGGGGGG 5'
새로 합성된 긴 생성물 1
5'......zzzzzzzzzzzzzzzzAAAAAAAAAAXXXXXXXXXXCCCCCCCCCCzzzzzzzzzzzzzz.....3'
원형 주형 본쇄+
5'AAAAAAAAAAAXXXXXXXXXXCCCCCCCCCCzzzzzzzzz......3'
새로 합성된 긴 생성물 2
3'zzzzzzzzzzzzzzTTTTTTTTTTYYYYYYYYYYGGGGGGGGGGzzzzzzzzzzzzzz......5'
원형 주형 본쇄+
3'TTTTTTTTTTYYYYYYYYYYGGGGGGGGGG 5'
새로 합성된 [S-]
5'AAAAAAAAAAXXXXXXXXXXCCCCCCCCCCzzzzzzzzzzzzzzzz......3'
첫 번째 사이클에서 합성된 긴 생성물 2
한 개 프라이머의 올리고뉴클레오타이드 서열 및 다른 상보적 서열로 종결되는 각 본쇄는 생산하기에 바람직한 특정 핵산 서열임을 알 수 있다.
이 방법의 단계는 존재하는 프라이머 1 및 2. 유도체 및 뉴클레오타이드의 양에 의해 제한받을 뿐, 무한하게 반복할 수 있다. 원형 핵산의 양은 전 방법에서 일정하게 남아있는데 이것은 복제되지 않기 때문이다. 긴 생성물의 양은 그들이 단지 원형 핵산으로부터 제조되기 때문에 일직선으로 증가한다. 특정 서열의 양은 지수적으로 증가한다. 따라서 특정 서열은 우세한 종으로 된다. 이것은 하기 표에 설명되어 있는데, 표는 각 사이클에서의 효율을 100%로 가정하여 n 사이클 후 이론적으로 존재하는 본 종들의 상대량을 가리킨다 :
[0내지 n 사이클 후]
[이본쇄의 수]
Figure kpo00034
일본쇄 핵산을 주형으로 사용하면, 사이클당 단지 하나의 긴 생성물이 형성된다.
여기에서의 방법은 적당한 발현 벡터속에 삽입시 특정 핵산 서열을 클론하는데 사용할 수 있다. 이어서 벡터는 적당한 숙주 유기체를 형질전환시키는데 사용하여 재조합 DNA 기술의 표준 방법에 의해 서열의 유전산물을 생산할 수 있다.
게다가 본 방법은 생체의 돌연변이시 사용할 수 있다. 올리고데옥시리보뉴클레오타이드 프라이머가 증대시킬 DNA서열에 정확히 상보적일 필요는 없다. 그들이 증대될 서열과 폴리머라제 효소 또는 사용한 다른 유도제에 의해 충분히 하이브리드화할 수 있으면 된다. 사용한 프라이머가 원혀 주형에 완전히 상보적이 아닌 폴리머라제 연쇄 반응의 생성물은 주형보다는 오히려 프라이머 서열을 함유해서 생체외 돌연변이를 유발할 것이다. 다음 사이클에서 이 돌연변이는 저하하지 않는 효율로 증대되는데, 이유는 더 이상 잘못 짝지어진 프라이밍(primings)이 요구되지 않기 때문이다. 그렇게 생성된 돌연변이체는 표준 분자 생물학적 기술에 의해 적당한 벡터로 삽입하며, 이 벡터상에 변화단백질의 생성 능력과 같은 돌연변이 특성을 부여할 수 있다.
상술한 바와 같이 변화된 DNA서열을 만드는 방법은 상이한 프라이머를 사용하여 변화된 DNA상에서 반복함으로써 그밖의 서열 변화를 유도할 수 있다. 이런 식으로 일련의 변이 서열이 점차 생성되며, 이 일련에 대한 새로운 부가는 바로 전의 것과 조금씩 다를 수 있으나 원형의 DNA원천 서열과는 점차적으로 크게 다르다. 이렇게 하여 궁극적으로 변화시킬 수 있으며, 아주 심하게 잘못연결된 프라이머는 기능을 갖지 못하므로 1단계로서는 불가능하다.
더불어 프라이머는 프라이머의 충분한 양이 증대시킬 서열에 상보적인 서열을 함유하는 비-상보적 서열을 그의 서열의 일부로서 함유할 수 있다. 예를 들면 주형 서열에 상보적이 아닌 뉴클레오타이드 서열(예 : 프로모터, 링커, 코드화서열 등)은 프라이머의 양쪽 또는 한쪽의 5'말단에 부착될 수 있으며, 그로인해 증대 공정의 생성물에 덧붙일 수 있다. 증대 프라이머를 가한 후, 충분한 사이클을 진행시켜 비-상보적인 뉴클레오타이드 삽입물을 함유하는 신규 주형의 목적하는 양을 취할 수 있다. 이것은 단순한 기술을 사용하여 비교적 짧은 시간(예 : 2시간 또는 그 이하)에 다량의 결합 단편을 생산하게 한다.
이 방법은 또한 감염성 질병, 암과 같은 유전자성 질환 또는 세포성 질환과 결부된 특정 핵산 서열의 검출 및/또는 특정화를 하는데 사용할 수 있다. 증대는 분석할 핵산이 매우 작은 경우, 예를 들면 태아 세포로부터 수득한 DNA를 사용하여 겸상적혈구 빈혈증의 태아가 진단시 유용하다. 증대는 그와 같은 분석을 비-방사성 검출법을 사용하여 본래 둔감한 소량의 샘플에 대해 수행할 때, 또는 방사성 기술을 사용하되 신속한 검출이 요구될 대 특히 유용하다.
본 발명의 목적인 유전병은 특정 유기체로부터 게놈 DNA상의 특정 결실 및/또는 돌연변이, 예를 들면, 겸상적혈구 빈혈, 낭포성 섬유화(cystic fibrosis), α-중증성 지중해 빈혈(thalessemia), β-중증성 지중해 빈혈등을 포함한다. 겸상적혈구 빈혈은 본 방법에 의해서 적당한 DNA 서열의 증대에 이어 RFLP-형분석 또는 올리고머 제한 분석을 통해 쉽게 검출할 수 있다. α-중증성 지중해 빈혈은 서열의 부재에 의해 검출할 수 있고, β-중증성 지중해 빈혈은 질병을 일으키는 돌연변이에 근접하여 연결된 다형성 제한 부위의 존재에 의해 검출할 수 있다.
이 모든 유전적 질병은 적당한 서열을 증대시키고 방사성 탐침 사용없이 서던 블롯(Southern blots)으로 그것을 분석하여 탐지할 수 있다. 그런 방법에서, 예를 들면 목적하는 아주 낮은 정도의 서열을 함유하는 양수로부터 소량의 DNA 샘플을 증대시키고, 제한 효소로 절단하며, 서던 블롯 기술을 통해 분석한다. 비-방사성 프로브의 사용은 고수준의 증대 신호에 의해 용이하게 한다.
또 다른 태양에서 작은 DNA 샘플은 통상의 수준으로 증대되고, 쉽게 탐지될 수 있는 뉴클레오타이드유도체(예 :32P-표지 도는 비오틴 표지된 뉴클레오타이드 삼인산)를 최종 DNA 생성물에 직접 결합시킴으로써 증대반응의 그밖의 사이클을 수행하여, 제한 및 전기영동 분리 또는 기타의 적당한 방법으로 분석한다. 이 기술의 실시예가 모델 시스템으로 제5도에 설명되어 있다.
제3도에 모델 시스템으로 설명되고 있는 그밖의 태양에서, 핵산은 증대되기 전에 특정 제한 엔도뉴클레아제에 노출된다. 절단된 서열은 증대될 수 없기 때문에, 증대 단편의 출현은 DNA 샘플의 앞서의 제한에도 불구하고 증대된 서열내에 엔도뉴클레아제를 위한 부위가 부재한다. 증대 서열의 존재 또는 부재는 적당한 방법으로 탐지한다.
이 기술의 실제적 응용은 아래 본문 및 문헌 [R. Saiki et al., Bio Technology, 3 : 1008-1012 (1985)]에 기술된 올리고머 제한 기술을 통해 겸상적혈구 빈혈의 탐지를 용이하게 하는데 있어서의 그의 용도에 의해 설명할 수 있다. 겸상적혈구 빈혈은 β-글로빈 유전자의 6번째 코돈에 단일 염기쌍 변화가 일어나 유발되는 헤모글로빈 질환이다. 제6도는 그의 다형성 부위에서 정상 및 겸상적혈구 β-글로빈 유전자의 서열을 명시하고 있는데, 단선(Single bars)은 경상 유전자에만 존재하는 Dde I 부위의 위치를 표시하고, 복선(double bars)은 비-다형성이고 따라서 정상 및 겸상적혈구 대립인자에 존재하는 Hinf I 부위의 위치를 표시한다. 제7도는 제한 부위 및 별표로 나타낸 표지를 함유할 프로브를 사용하여 정상 β-글로빈 DNA를 올리고머 제한하는 방법을 설명한다. 여기에서 제공된 증대 DNA를 변성시키고 표지 프로브에 아닌(anneal)시킨다. 효소 Dde I는 DNA를 재형성된 Dde I 부위에서 절단하여 표지된 옥타머(Octamer)를 생성한다. 시험에 사용한 조건하에서 옥타머는 이본쇄로부터 분리될 정도로 충분히 작다. 효소 Hinf I의 후속적 부가는 새로운 일본쇄 옥타머에 효과가 없다. 제8도는 β-글로빈 DNA의 겸상적혈구 대립인자에 적용된 동일 방법을 설명하고 있다. 효소 Dde I는 잘못 짝지어진 A-A 염기쌍으로 인해 증대 DNA 및 표지된 프로브에 의해 형성된 이본쇄를 절단하지 못한다. 그러나 효소 Hinf I은 하이브리드를 제한하여 표지된 트리머(trimer)를 생성시킨다. 실제 이 방법은 특정 신호가 각 대립인자의 존재와 결부되기 때문에 야생형에 동형접합성인 것, 겸상형에 동형접합성인 것, 또는 겸상 적혈구 특성에 이형 접합성인 담체로서 개개의를 감별할 수 있다. 상술한 적절한 서열의 증대 방법의 사용은 단지 단일 DNA 표지된 탐침을 이용해서 단일32P 복제 유전자의 신속한 분석을 허용한다.
여러 가지 감염성 질병은 원인 미생물에 특징적인 특정 DNA 서열의 임상적 샘플의 존재에 의해서 진단할 수 있다. 이들은 살모넬라, 클라미디아, 네이세리아(Neisseria)와 같은 세균, 간염 비루스와 같은 비루스 및 말라리아의 원인인 프라스모듐(plasmodium)과 같은 원생동물의 기생충 등이다. 팔코우(Falkow)가 출원한 미합중국 특허 제4,358,535는 감염성 질병의 진단용으로 특정 DNA 하이브리드화 프로브의 용도를 기술하고 있다. 팔코우 방법에 수반되는 문제는 비교적 소수의 독성 유기체가 감염된 환자로부터 임상 샘플에 존재하고 이들로부터 추출한 DNA가 샘플의 총 DNA중 극히 소부분을 구성할 수 있다는 것이다. DNA 샘플의 고정화 및 하이브리드화 검출전에 예상되는 서열의 특수한 증대는 이 방법의 감도 및 특성을 크게 증진시킬 수 있다.
감염성 질병의 진단시 DNA 프로브의 일반적 임상 용도는 만일 워드(ward)의 EP 63,879에 기술된 바와 같이 비-방사성적으로 표지된 프로브를 사용하는 경우 상당히 단순해진다. 이 방법에서는 비오틴-함유 DNA프로브를 아비딘 또는 비오틴-특이성 항체에 연결된 색원성 효소에 의해 검출한다. 이런 형의 검출이 편리하나, 비교적 민감치 못하다. 본 방법에 의한 특정 DNA 증대 및 안정하게 표지된 프로브의 배합은 일반적인 임상 사용에 팔코우 및 워드 방법을 유용하게 만드는데 요구되는 편리함과 민감함을 제공한다.
증대 방법은 또한 단일 복제 사람 유전자로부터 DNA를 충분한 양으로 제조하는데 사용하여 에티디움 브로마이드와 같이 간단한 비-특이성 DNA 염료를 이용하여 직접 DNA 진단을 할 수도 있다.
유기체의 게놈에서 감염성 질병 및 독성적 비정상을 탐지하는 외에, 본 방법은 특정 독성적 상태와 연관되지 않은 DNA 다형현상을 검출하는데 사용할 수도 있다.
하기 실시예들은 설명의 방법으로 제공된 것으로 어떻게 해서든 본 발명을 제한하지는 않는다. 이들 실시예에서 모든 백분율은 고체의 경우 중량에 의한 것이고 액체인 경우 용적에 의한 것이며, 모든 온도는 다른 주해가 없는 한 섭씨 온도이다.
[실시예 1]
ATCC로부터 입수 가능한 pBR322의 47염기쌍 Fok I 제한 단편 상에 함유되어 있는 뉴클레오타이드 서열
5' CCTCGGCACCGTCACCCTGGATGCT 3'
3' GGAGCCGTGGCAGGGACCTACGA 5'
을 갖는 25염기쌍 서열은 하기와 같이 제조한다. 47-bp 단편을 함유하는 pBR 322의 Fok I 분해물은 제공자인 뉴 잉글랜드 바이오랩스 인코포레이티드(New England Biolabs Inc.)사에 의해 제안된 조건에 따라 pBR 322의 Fok I으로 분해시켜 제조한다. 이용되는 프라이머들은 5'd(CCTCGGCACCG)3' 및 5'd(AGCATCCAGGGTG)3'이며, 통상적인 기술을 사용하여 제조한다. 하기 성분들 [즉 상기 기술한 프라이머들 각각 2433피코몰, pBR 322의 Fok I 분해물, 2.4피코몰, dATP 12나노몰, dCTP 22나노물, dGTP 19나노몰 및 TTP 10나노몰]을 25mM 인산칼륨, 10mM 염화마그네슘 및 100mM 염화나트늄으로 이루어진 완충액(pH 7.5) 33㎕에 가한다.
혼합물을 85℃로 5분동안 가열한 다음 주변 온도로 냉각시킨다. 이. 콜라이 DNA 폴리머라제(I)의 클레노우 단편 5-단위를 가하여 온도를 15분 동안 그대로 유지시킨다. 그후, 혼합물을 다시 85℃로 5분동안 가열한 다음 냉각시킨다. 클레노우 단편 5단위를 다시 가하여 반응을 15분동안 수행한다. 가열, 냉각 및 합성단계를 11회 이상 반복 수행한다.
최종 반복 수행후, 분취량 5㎕을 반응 혼합물로부터 취한다. 이것을 85℃로 3분동안 가열한 다음 주변온도로 냉각시킨다. α-P32-데옥시시티딘 트리포스페이트 12.5피코몰 및 클레노우 단편 5단위를 가하여 반응을 15분동안 게속 수행한다. 표지한 생성물을 폴리아크릴아미드겔 전기영동에 의해 검사한다. Fok I 분해물을 유사한 형태로 표지하여 대조용 및 분자량 표지물로 제공한다. 사이클을 13회 반복 수행한 후 확실시 관찰할 수 있는 표지 밴드가 목적하는 25염기쌍 서열이다.
[실시예 2]
목적하는 증대시킬 서열은 인체의 베타-글로빈 유전자내에 함유되어 있으며 겸상적혈구 빈혈증에 관련된 Mst II 부위를 함유(spanning)하는 94염기쌍 서열이다. 이 서열은 제1도에 나타낸 뉴클레오타이드 서열을 갖는다.
[I. 프라이머 합성]
하기 2개의 올리고 데옥시리보뉴클레오타이드 프라이머를 하기 기술한 방법으로 제조한다.
5' CACAGGGCAGTAACG 3' 프라이머 A
5' TTTGCTTCTGACACA 3' 프라이머 B
자동조작 합성방법 : 하기 문헌[Beauage 및 Caruthers : Tetrahedron Letters (1981) 22 : 1859-1862]에 기술된 방법에 따라 합성한 디에틸 포스포르아미드트 들을 바이오서치(Biosearch) SAM-1을 사용하여 뉴클레오사이드 유도된 조절 다공성 유리 지지체에 연쇄적으로 축합시킨다. 이 방법에는 디클로로메탄중에서 트리클로로아세트산을 사용하여 탈트리틸화시키는 반응(detritylation), 활성 양자 공여체로 벤조트리아졸을 사용하는 축합반응, 및 테트라하이드로푸란 및 피리딘중에서 무수 아세트산 및 디메틸아미노피리딘을 사용하여 캐핑시키는 반응(capping)이 포함된다. 사이클을 1회 수행하는 시간은 약 30분이다. 각 단계에서의 수율은 필요한 양이며, 이것은 탈트리틸화 반응 동안에 방출된 디메톡시트리틸 알콜을 회수하여 분광 분석하여 측정한다.
올리고데옥시리보뉴클레오타이드 보호해제 및 정제 방법 : 고체 지지체를 칼럼으로부터 제거하여 밀폐 튜브 내 실온에서 4시간동안 농 수산화암모늄 1㎖에 노출시킨다. 지지체를 여과하여 제거한 다음 부분적으로 보호된 올리고데옥시튜클레오타이드를 함유하는 용액을 5시간동안 55℃로 되게 한다. 암모니아를 제거하고 잔류물을 예비 폴리아크릴아미드 겔에 올려놓는다. 30Volts/㎝에서 90분동안 전기 영동시킨 다음 생성물을 함유하는 밴드를 형광판의 UV 사진으로 확인한다. 밴드를 절단하여 4℃에서 밤새증류수 1㎖로 용출시킨다. 이 용액을 Altech RP/8칼럼에 올려놓고 1% 암모늄 아세테이트 원출액(pH 6.0)중의 아세토니트릴 7 내지 13%로 용출시킨다. 용출액을 260mm에서 UV 흡광도로 모니터(monitor)하고 적절한 분획을 회수하여 고정 용적에서 UV흡광도로 정량 분석하고 진공 원심분리기내 실온에서 증발건고시킨다.
올리고데옥시리보뉴클레오타이드 특징화 : 정제된 올리고뉴클레오타이드 테스트 분취량을 폴리뉴클레오타이드 키나제 및 r-32p-ATP를 사용하여32로 표지한다. 표지한 화합물을 50Volts/㎝에서 45분동안 전기영동시킨 당므 14 내지 20% 폴리-아크릴아미드겔의 사진으로 검사한다. 이 방법으로 분자량을 입증한다. 염기 조성물은, 독액 디에스터라제(venom diesterase) 및 세균성 알칼리 포스파타제를 사용하여 올리고데옥시리보뉴클레오타이드 뉴클레오사이드들로 분해시킨 다음, 분리하고, 역상 HPLC 칼럼 및 10% 아세토니트릴, 1% 암모늄 아세테이트 유동상을 사용하여, 유도된 뉴클레오사이드들을 정량분석하여 측정한다.
[II. DNa 원]
A. 전인체의 야생형 DNA의 추출
정상적인 β-글로빈에 동형 접항성인 인체게놈의 DNA를 세포라인 Molt 4(Human Genetic Mutant Cell Repository사로부터 입수, GM 2219c)로부터 하기 문헌[Stetler et al., Proc, Nat Acad. sci. (1982), 79 : 5966-5970]에 기술된 기법을 사용하여 추출한다.
b. 클론된 글로빈 유전자의 제조
정상적인 β-글로빈 유전자의 1.9kb BamH-1 단편을 코스미드(cosmid)pFC11로부터 단리시켜 pBR328의 BamH I부위에 삽입시킨다. Soberon et al., Gene(1980) 9 : 287-305. 이 단편은 합성 40-머탐침으로 하이브리드화 시킬 부위를 에워사고 있는데, 첫 번째 및 두 번째 액손(exon), 첫 번째 인트론(intron) 및 유전자의 5'측면 서열을 포함하고 있다[Lawn et al., Cell (1978(, 15 : 1157-1174]. 이 클론은 pBR 328 : HbA로 표기하며 ATCC 제39698호로 1984년 5월 25일에 기탁하였다.
상응하는 β-글로빈의 경상 적혈구 대립인자의 1.9kb
Figure kpo00035
H I 단편은 코스미드 pFC 12로부터 단리시켜 상기 기술한 바대로 클론한다. 이 클론은 pBR 328 : Hbs로 표기하여 ATCC 제39699호로 1984년 5월 25일에 기탁하였다.
각 재조합 플라스미드를 형질전환시켜 이. 콜라이 MM 294(ATCC 제39,607호)에서 증식시킨다.
C. 클론된 글로빈 유전자를 Mst II로 분해시키는 방법
pBR 328 : HbA 및 pBR 328 : Hbs 각각을 전체 100μ씩으로, 각기 150mM NaCl, 12mM 트리스 HCL(pH 7.5), 12mM ㎎Cl2, 1mM 디티오트레이톨(DTT) 및 100㎍/㎖ 소의 혈청 알부민(BSA)으로 이루어진 용액 200㎕ 중, 37℃에서 16시간동안 Mst II 20단위 (New England Biolabs)로 분해시킨다. 생성물은 각각 pBR 328 : HbA.Mst II 및 pBR 328 : HbS II로 표기한다.
III. 폴리머라제 연쇄 반응
60mM 나트륨 아세테이트, 30mM 트리스 아세테이트 및 10mM 마그네슘 아세테이트로 이루어진 완충액(pH 8.0) 100㎕에, 프라이머 A(서열 CACAGGGCACTAACG)100피코몰, 프라이머 B(서열 d(TTTGCTTCTGACACA)) 100피코몰 및 dATP, dCTP, dGTP 및 TTP 각 1000피코몰를 함유하는 용액 2㎕로 가한다. 상기 기술한 DNA이 하기원중 하나를 가한다.
전 인체의 야생형 DNA 10㎍(반응 I)
pBR 328 : HbA 0.1피코몰(반응 II)
pBR 328 : HbS 0.1피코몰(반응 III)
pBR 328 : HbA/Mst II 0.1피코몰(반응 IV)
pBR 328 : HbS/Mst II 0.1피코몰(반응 V)
표적 DNA부재(반응 VI)
각각의 생성된 용액을 100℃로 4분 동안 가열한 다음 실온으로 2분동안 냉각시키고, 이. 콜라이 DNA 폴리머라제의 클레노우 단편 4단우를 합유하는 1㎕를 가한다. 각 반응을 10분동안 수행한 후, 프라이머, 뉴클레오타이드 및 DNA를 가하여, 가열하고, 냉각시키고, 폴리머라제를 가하는 사이클을, 반응(I)의 경우에는 19회, 반응(II) 내지 반응(VI)의 경우에는 4회 반복 수행한다.
각 반응의 첫 번째 사이클전에 그리고 최종 사이클후에 취한 반응(I) 및 반응(II)의 분취량 4마이크로리터를, 0.089M 트리스-브레이크 완충액(pH 8.3) 및 2.5mM EDTA 중의 12% 폴리아크릴아미드겔에 올려 놓는다. 겔을 25Volts/㎝에서 4시간동안 전기 영동시켜, 고체 상 지지체로 제공된 나일론 막에 옮긴 다음, 30% 포롬아미드, 3×sspE, 5×Denhardt's 5% 나트륨 도데실 설페이트(pH 7.4)중에서, 표준 기법으로 제조한 하기 서열을 갖는 5'-32P로 표지된 40bp 합성 단편으로 탐침한다 : 5'd(TCCTGAGGAGAAGTCTGCCGTTACTGCCCTGTGGGGCAAG) 3'
제2도는 반응(I) 및 반응(II)의 경우 탐침된 나일론 막의 방사선 사진이다. 레인 1은 그의 본쇄 하나가 상기 탐침에 상보적인 58-bp 합성 단편 조절자 0.1피코몰이다. 레인 2는 반응(I)의 첫 번째 증대 사이클을 수행하기 전의 4㎕이다. 레인 3은 반응(I)의 증대 사이클을 20회 수행한 후에 4㎕이다. 레인 4는 반응(II)의 증대 사이클을 5회 수행한 후의 4㎕이다. 레인 5는 알파-32P-dNTPs 및 폴리머라제로 표지한 pBR 322(New England Biolabs) Fok I(New England Biolabs) 분해물로 이루어진 분자량 표준이다. 레인 3은 사이클을 20회 수행한 후에 반응 혼합물(I)이 적절한 분자량이 갖는 특정 서열을 상당량 함유하지만 다른 탐지 가능한 생성물을 함유하지 않음을 보여준다. 레인 4에서 볼 수 있는 바와 같이, 사이클을 5회 수행한 후에 반응 혼합물(II)은 이 생성물 뿐만 아니라, 출발핵산 및 다른 생성물을 함유한다.
반응 사이클로 4회 수행한 후의 반응(II) 내지 반응(VI)의 분취량 5.0㎕에 상기 기술한 각 프라이머 5피코몰을 가한다. 용액을 4분 동안 100℃로 가열한 다음 실온이 되게 한다. 알파-32P-dATP 알파-32P-dCTP 알파-32P-dGTP 및 알파-32P-dTTP 각각 3피코몰 및 클레노우 단편 4단위를 가한다. 최종 용적 10㎕중, 상기 기술한 염 농도에서 반응을 10분 동안 진행시킨다. 폴리머라제 활성은 60℃에서 20분 동안 가열하l면 상실된다. 반응(II) 내지 반응(VI)의 분취량 4㎕를 0.089M트리스-브레이트 완충액 (pH 8.3) 및 2.5mM EDTA 중의 12% 폴리아크릴아미드 결상에 올려 놓는다. 겔을 25Volts/㎝에서 4시간 동안 전기 영동시킨 후 사진을 찍는다.
제3도는 전기 영동사진이다. 레인 1은 분자량 표준이고, 레인 2는 반응(II이며, 레인 3은 반응(III)이고, 레인 4는 반응(IV)이며 레인 5는 반응(V)이다. 조절자로 DNA를 갖지 않은 반응(VI)에 대한 레인은 어느 레인에서도 그 상(image)이 나타나지 않는다. 도면으로부터, 표적 DNA로부터 예상된 94-bp 단편은 손상되지 않은 β-글로빈 DNA 서열이 증대 가능한 경우, 즉 pBR 328 : HbA(레인 2), pBR 328 : HbS(레인 3) 및 pBR 328 : HbS/Mst II(레인 5)에서만 나타남을 알 수 있다. Mst II 분해로 pBR 328 : HbAd[사 94-머 서열이 증대될 수 없도록 절단되어, 94-머 서열은 레인 4에서 나타나지 않았다. 대조적으로, pBR 328 : HbS에서 94-머 서열은, 플라스미드를 Mst II로 분해시키는 경우, 절단되지 않으므로 레인 5에서 볼 수 있는 바대로 증대 가능하다.
제4도는 94-bp 서열을 증대시킴에 있어 3개의 사이클의 연쇄 반응을 설명한 것이다. PCO1 및 PCO2는 프라이머 A 및 B이다. 오른편에 있는 숫자는 사이클을 나타내고, 왼편에 있는 숫자는 특정 분자가 생성되는 사이클 번호를 나타낸다.
[실시예 3]
이 실시에는 인체의 헤모글로빈 유전자에 있어 대립인자의 Mst II 부위를 함유하는 110bp 서열의 증대를 설명하는 것이다.
실시예 2의 기법으로 재조한 전인체의 DNA 1.0마이크로그램, 프라이머 d(ACACAACTGTGTTCACTAGC) 100피코몰 및 프라이머 d(CAACTTCATCCACGTTCACC)100피코몰 전체를 하기 성분으로 이루어진 용액 100㎕에 용해시킨다.
각 1.5mM인 4개의 데옥시 리보뉴클레오사이드 트리포스페이트.
30mM 트리스 아세테이트 완충액(pH 7.9)
60mM 나트륨 아세테이트
10mM 마그네슘 아세테이트
0.25mM 디티오트레이톨
용액을 1분 동안 100℃로 가열한 다음 1분 동안 재빨리 25℃로 되게한 후, DNA 폴리머라제의 클레노우 단편 2.5단위를 가한다. 폴리머라제 반응을 25℃에서 2분 동안 진행시킨 후, 가열하여, 냉각시키고, 클레노우를 가하는 사이클 반응을 목적으로 만큼 자주 반복 수행한다.
각 사이클을 70% 효율로, 15회 반복 수행하면 β-글로빈 유전자의 목적하는 110bp 단편 1.4펨토몰이 합성된다.
[실시예 4]
이 실시예는 인체의 헤모글로빈 유전자에 있어 대립인자의 Mst II 부위를 함유하는 240pb 서열의 증대를 설명하는 것이다. 이 서열은 Nco I, Hinf I 및 Mst II 제한 부위들을 함유한다.
pBR 328 : HbA 0.1 피코몰을 함유하는 60mM 나트륨 아세테이트, 30mM 트리스 아세테이트 및 10mM 마그네슘 아세테이트의 혼합물(pH 8.0) 100㎕에 하기 성분을 함유하는 용액 A 2㎕를 가한다 :
d(GGTTGGCCAATCTACTCCCAGG) 프라이머 100피코몰
d(TAACCTTGATACCAACCTGCCC) 프라이머 100피코몰
dATP, dCTP, dGTP 및 TTP 각각 1000피코몰.
실시예 2에 기술된 기법으로 2개의 프라이머를 제조한다. 용액을 4분동안 100℃로 가열한 다음 2분 동안 주변 공기중에서 냉각시킨 후, 이. 콜라이 DNA 폴리머라제의 클레노오 단편 4 단위를 함유하는 1㎕를 가한다. 반응을 10분동안 진행시킨 후, 용액 A를 가하고, 가열하여 냉각시키고, 폴리머라제를 가하는 사이클 반응을 3회 반복수행한다. 반응물의 분취량 5.0㎕에 상기 기술한 올리고뉴클레오타이드 프라이머 각 5피코몰을 가한다. 용액을 4분 동안 100℃로 가열한 다음 주변 온도로 되게한 후, 알파-32P로 표지된 데옥시리보뉴클레오사이드 트리포스페이트각 3피코몰 및 플레노우 단편 4 단위를 가한다. 최종 용적 10㎕중, 상기 기술한 염 농도에서 반응을 10분동안 진행시킨다. 폴리미라제 활성은 60℃에서 20분 동안 가열하면 상실된다. 분취량 2㎕를 Nco I, Mst II 또는 Hinf I로 분해시킨 후 0.089M 트리스-보레이트 완충액(pH. 8.3) 및 2.5mM EDTA중의 중의 12% 폴리아크릴아미드 겔상에 올려놓는다. 겔은 25Volts/㎝에서 4시간 동안 전기 영동시킨 후 사진을 찍는다. 제5도는 전기 영동 사진인데, 여기에서 레인 1은 분자량 표준이고, 레인 2는 효소로 분해시키지 않은 것(상되지 않은 240bp)이며, 레인 3은 Nco I으로 분해시킨 것(131 및 109bp)이고, 레인 4는 Mst II로 분해시킨 것(149 및 91bp)이며, 레인 5는 Hinf I로 분해시킨 (144 및 96bp)이다. 사진은 240bp 서열의 증대와 일치한다.
[실시예 5]
이 실시예는 겸상절혁구 빈혈증을 연쇄적 분쇄에 의해 탐지하고자 하는 본 발명의 방법의 용도를 설명하는 것이다.
[올리고데옥시리보 뉴클레오타이드의 합성 및 탈인산화]
하기 서열을 갖는, 표지한 DNA 탐침 RS06 :
5'*CTGACTCCTGAGGAGAAGTCTGCCGTTACTGCCCTGTGGG 3'
(여기에서, *는 표지를 나타냄), 및 하기 서열을 갖는 표지하지 않은 블록 올리고머 RS10 :
3'GACAGAGGTACCTCTCAGACGGCAATGACGGGACACCC 5'
(RS06과는 3개의 염기쌍이 잘못 짝지어져 있다)을 실시예 2(Ⅰ)에 기술된 방법에 따라 합성한다. 탐침 RS06은, 이 RS06 5피코몰을, 70mM 트리스완충액 (pH 7.6), 10mM ㎎Cl21.5mM 스페르민 및 2.5mM 디티오트레이톨을 함유하는 반응물 용적 40㎕중, 37℃에서 90분 동안 T4 폴리뉴클레오타이드 키나제(New England Biolabs) 4단위 및 γ-32P-ATP(New England Nuclear, dir 7200Ci/mmole) 50피코올과 접촉시켜 표지한다. 전체 용적을 25mM EDTA로 100㎕로 조정한 다음, 트리스-EDTA(TE) 완충액(10mM 트리스 완충액, 0.1mM EDTA pH 8.0)으로 채운 바이오래드(BioRad)사 제품인 Bio Gel P-4스핀 투석 칼럼상에서 하기 문헌[Maniatis et al,
Figure kpo00036
(1982), 464-465]에 기술된 방법에 따라 정제한다. 표지된 탐침은 트리스-붕산-EDTA(TBE)완충액(89mM 트리스, 89mM 붕산, 2.5mM EDTA pH8.3)중의 18% 폴리아크릴아미드 겔(19 : 1아크릴아미드 : BIS, BioRad사)사에서 500vhr 동안 전기 영동시켜 더 정제한다.
사진을 찍어 위치를 측정한 후, 표지된 탐침을 함유하는 겔의 부위를 절단하여, 분쇄하고, TE 완충액 0.2㎖내로 4℃에서 밤새 용출시킨다. 반응 새성물을 TCA로 침전시킨 결과 고유 활성은 4.9 Ci/mmole이고 최종 농도는 20pmole/㎖이다.
표지하지 않은 RS10 블록 오리고머는 200pmole/㎖의 농도로 사용된다.
[세로 라인으로부터 인체 게놈의 DNA의 단리]
고분자량을 갖는 게놈의 DNA를, 본질적으로 하기 문헌[Stetler et al.,
Figure kpo00037
(1982)
Figure kpo00038
, 5966-5970(Molt 4의 경우) 및 Maniatis et al.,
Figure kpo00039
(1982), 280-281]에 기술된 방법을 사용하여 임파 세포라인 Molt 4, SC-1 및 GM2064로부터 단리시킨다.
Molt 4(Human Mutant Cell Repository GM 2214C)는 정상적인 β-글로빈에 동형 접합성인 T세포라인이고, SC-1(1985년 3월 19일 ATCC에 기탁)은 겸상적혈구 빈혈중에 동형접합성인, EBV로 형질전환된 B 세포라인이다. GM 2064(Human Mutant Cell Repository GM 2064)는 원래 태아 헤모글로빈의 유전지속체(HPFH)에 각각 동형접합성인 것으로부터 단리시킨 것이며 베타-또는 델타-글로빈 유전자 서열은 함유하지 않는다. 모든 세포라인은 10% 송아지 태아혈정을 사용하여 RPMI-1640내에 저장한다.
[임상 혈액 샘플로부터 인체 게놈의 DNA의 단리]
알려진 겸상적혈구 담체(As)로부터 CH12로 표기된 임상 혈액 샘플을 미합중국 캘리포니아 오클랜드 소재의 Children's Hospital에 근무하는 Bertram Lubin 박사로부터 입수하였다. 게놈의 DNA는, 주로 말초혈액 임파구 세포(peripheral blood lymphocytes)로 이루어진 연층 분획(buffy coat fraction)으로부터, 하기 문헌[Nunberg et al.,
Figure kpo00040
, 5553-5556(1978)에 기술된 방법의 수정방법을 사용하여 제조한다.
세포를 트리스-EDTA-NacL(TEN) 완충액(10mM 트리스 완충액 pH 8, 1mM EDTA 10mM NaCl) 5㎖에 재현탁시켜, 0.2㎎/㎖ 프로테이나제 K, 0.5% SDS로 조정한 다음 37℃에서 밤새 배양한다. 과염소산 나트륨을 0.7M로 가한 후 용균물(lysate)을 실온에서 1 내지 2시간 동안 부드럽게 진탕시킨다. 용균물을 페놀/클로로포롬(1 : 1) 30㎖로 추출한 후, 클로로포름 30㎖로 추출하고, 이어서 핵산을 에탄올 침전시킨다. 펠렛을 TE 완충액 2㎖에 재현탁시켜 RNase A를 0.005㎎/㎖로 가한다. 37℃에서 1시간 동안 분해시킨 후, DNA를 페놀, 페놀/클로로포롬 및 클로로포름 각 동용적으로 1회씩 추출한 후, 에탄올 침전시킨다. DNA를 TE 완충액 0.5㎖에 재현탁시켜, 260nm에서의 흡광도로 농도를 측정한다. 선택적으로 β-그로빈 서열을 증대시키기 위한 폴리머라제 연쇄 반응.
게놈의 DNA2 마이크로그램을, 10mM 트리스 완충액(pH 7.5), 50mM NaCl 10mM MgCl2서열의 프라이머 A d(CACAGGGCACTAACG) 150피코몰 및 서열의 프라이머 B d(CTTTGCTTCTGACACA) 150피코몰을 함유하는 초기 반응물 용적 100㎕에서 증대시켜 증발되지 않게 광유(mineral oil) dir 100㎕를 바른다.
각 DNA 샘플은 하기의 3단계로 이루어진 사이클을 15회 반복 수행하여 증대시킨다.
1) 95℃로 고정시킨 열 차단 세트내에서 2분 동안 변성시킨다.
2) 즉시 30℃로 고정시킨 열 차단 세트로 옮겨 2분 동안 보관하여 프라이머 및 게놈의 DNA가 어닐링되게 한다.
3) 10mM 트리스(pH 7.5), 50mM NaCl, 10mM MgCl2및 4mM 디티오트레이톨로 이루어진 완충액중에서, 이.콜라이 DNA 폴리머라제 I의 클레노우 단편(New England Biolabs) 5단위, dATP, dCTP, dGTP 및 TTP 각 1나노몰을 함유하는 용액 2㎕를 가한다. 이 증대반응을 30℃에서 10분 동안 진행시킨다.
최종적으로 사이클을 반복수행한 후, 반응은, 95℃에서 2분동안 가열하여종결시킨다. 광유를 클로로포름 0.2㎖로 추출하여 폐기한다. 최종의 반응물 용적은 130㎕이다. 증대된 게놈의 dna를 탐침 및 Dde I/Hinf I를 사용하여 하이브리드화/분해시키는 반응.
증대된 게놈의 DNA 45마이크로리터를 에탄올 침전시켜 TE 완충액 동용적에 재현탁시킨다. 10마이크로리터(게롬 DNA 154ng의 증대 전 등가물 함유)를 1.5㎖ 미크로퓨지 튜브에 분해하여 TE 완충액 20㎕로 최종 용적이 30㎖가 되게 한다. 샘플에 광유를 바른 후 95℃에서 10분 동안 변성시킨다. 표지된 RS06탐침 0.02피코몰을 함유하는 0.6M NaCl 10마이크로리터를 튜브에 가하여 부드럽게 혼합하고, 즉시 56℃로 고정시킨 열 차단 세트에 옮겨 1시간동안 보관한다. 표지하지 않은 RS10 블록 오리고머(0.8피코몰) 4마이크로 리터를 가하여, 동일한 온도에서 10분동안 더 하이브리드화를 계속한다. 60mM MgCl2/0.1% BSA 5마이크로리터 및
Figure kpo00041
I 1㎕(10단위, New England Biolabs)를 가하여, 제어닐링된 DNa를 56℃에서 30분동안 분해시킨다.
Figure kpo00042
I 1마이크로리터(10단위, New England Biolabs)를 가하여, 30분동안 더 배양한다. 반응은 75mM EDTA 4㎕ 및 추적 염료 6㎕를 최종 용적 61㎕가 되게 가하면 중지된다.
광유를 클로로포롬 0.2㎖로 추출하고, 반응 혼합물(45ng 게놈 DBA) 18㎕를 Hoeffer SE 200 장치내에서 30% 폴리아클리아미드 미니-겔(19 : 1, BioRad) 상에 올려놓는다. 겔을 약 300Volts에서 1시간동안, 브로모페놀블루 염료가 원점에서 3.0㎝ 이동할때가지, 전기 영동시킨다. 겔의 상부 1.5㎝를 제거하고 남아있는 겔을 -70℃에서 4일간 1개의 보력 스크린 (intensification screen)을 사용하여 노출시킨다.
[사진 설명(제9도)]
각 레인은 증대된 게놈 DNA 45ng을 함유한다. 레인 A는 Molt 4 DNA를 함유하고 : 레인 B는 CH12를 함유하여 : 레인 C는 SC-1을 함유하고 : 레인 D는 GM 2064를 함유한다. Molt 4는 세포당 βA유전자 2복 제본을 갖는 정상적인 개개의 유전자형(AA)을 나타내고, CH12는 세포당 하나의 βA및 하나의 βS유전자를 갖는 겸상적혈구 세포 담체로부터의 임상 샘플(AS)을 나타내며, SC-1은 세포당 βS유전자 2복제본을 갖는 겸상적혈구 세포 개개의 유전자형(SS)을 나타낸다. GM2064는 베타 - 또는 델타-글로빈 서열을 함유하지 않는데, 음성 조절자(negative control)로 존재한다.
사진에서 볼 수 있는 바와같이,
Figure kpo00043
I로 절단한 βA-특이성 옥타머는 βA-유전자를 함유하는 그러한 DNS's에서만 존재(레인 A 및 B)하고
Figure kpo00044
I로 절단한 βS-특이성 트리머는 βS유전자를 함유하는 그러한 DNA's에서만 존재(레인 B 및 C)한다. 트리머 및 옥타머 둘 모두의 존재(레인 B)는 겸상적혈구 세포담체에 대한 특징이고 옥타머만을 갖는 정상적인 개개(레인 A)와 구별 가능하고 트리머만을 갖는 개개에 의해 영향을 받은 겸상 적혈구 세포(레인 C)와도 구별 가능하다.
비교용으로, 증대되지 않은 게놈 DNA를 사용하여 상기 기술된 실험을 반복수행하면 증대가 탐지 민감도를 적어도 1000배까지 증가시킴을 알 수 있다.
[실시예 6]
이 실시예는 표지된 탐침을 필요치 않고서 겔상에서 전인체의 DNA에서의 전체적으로 정제되지 않은 단일 복제 유전자의 직접적인 탐지법을 설명하는 것이다.
실시예 3에 기술된 기법을 사용하며, 베타-글로빈 유전자의 첫 번째 액손에서의 서열로부터 110-bp 단편을, 사이클로 20회 반복수행한 후 전 인체의 DNA 10㎍으로부터 증대시킨다. 사이클을 20회 반복수행한 후 생성된 이 110-bp 단편을 에티디움 브로마이드로 염색을 겔상에서 쉽게 가시화된다.
서열은, 베타-글로빈 S 빈혈증에서 처럼, 서열이 효소에 의해 인석된 제한 부위를 함유하지 않는 경우는 제외하고, 서열이 제한 효소
Figure kpo00045
I으로 먼저 절단된 경우는 증대되지 않는다.
[실시예 7]
A. 인체의 베타-글로빈 A 빈혈증으로부터 1.9Kb 삽입물, 알파-32p-dNTP(500c : mole) 각 50 나노몰 및 실시예 3에서 사용된 프라이머 각 1나노몰을 함유하는 pBR328 100펨토몰 전체를 30mM 트리스-아세테이트(pH 7.9), 60mM 나트륨 아세테이트, 100mM 디티오트레이톨 및 10mM 마그네슘 아세테이트를 함유하는 용액 100㎕에 용해시킨다. 이 용액을 2분동안 100℃로 되게 한 다음 1분동안 25℃로 냉각시킨다.
Figure kpo00046
DNA 폴리머라제 1의 클레노아 단편 4.5 단위 및 무기 피로포스파타제 0.09 단위를 함유하는 1㎕ 전체를 가하여 반응 혼합물에서 피로포스페이트의 축적(build-up)가능성을 방지하고, 반응을 25℃에서 2분동안 진행시킨 후, 가열하여, 냉각시키고, 효소를 가하는 사이클반응을 9회 반복수행한다. 분취량 10㎕를 취하여 600mM EDTA 1㎕에 가한 후 각 합성사이클을 수행한다. 각각은 90mM 트리스-보레이트 및 2.5mM EDTA중의 14% 폴리아크릴아미드겔상 pH 8.3 및 24 Volts/㎝에서 2.5시간 동안 분석한다. 완성된 겔을 0.5㎍/㎖ 에티디움 브로마이드를 가하면서 동일한 완충액에 20분동안 담근후, 원래의 완충액으로 세척하고, 적색 필터를 사용하여 UV광에서 사진을 찍는다.
생성된 110-bp 단편을 UV 광 하에서 겔로부터 절단하여 세렌코브 방사(cerenkov radiation)에 의해 카운트된32p를 혼입시킨다. 하기 방정식 : pmoles/10㎕=0.01[(1+y)N-yN-1] {여기에서, N은 사이클의 수이고 y는 사이클당 분획 수율이다}의 데이터를 적절히 하기 위한 시도로 y=0.619일 경우 최적이다. 이것으로 상당한 양의 증대가 발생했음을 알 수 있다.
B. 각 dNTP 100 나노몰을 반응물 100㎕에 가하고, 방사선 표지를 사용하지 않으며, 분취량을 각 사이클에서 취하지 않는 것을 제외하고는 상기 실험을 반복 수행한다. 사이클을 10회 반복 수행한 후 2분동안 비등시켜 반응을 종결시키고 57℃에서 1시간동안 재하이브리드화를 수행한다. 110-bp 생성물의 서열은, 분위량 8㎕에 소혈청 알부민(25㎎/㎖) 1㎕ 및 적절한 제한 효소(
Figure kpo00047
)1㎕를 가한 후 37℃에서 15시간동안 반응시킴에 의한 제한 분석으로 확인한다. PAGE도 상기 기술한 바와 같이 수행한다.
[실시예 8]
이 실시예는 pBR328 및 pBR322의 여러 단편을 증대시키기 위한 상이한 프라이머의 용도를 설명한 것이다.
A. 하기 프라이머 : d(TTTGCTTCTGACACAACTGTGTTCACTAGC) 및 d(GCCTCACCACCAACTTCATCCACGTTCACC)를 사용하는 것을 제외하고는, 실시예 7A에 기술된 실험을 반복수행하여 pBR328의 130-pbeks단편을 수득한다.
B. 하기 프라이머 : d(GGTTGGCCAATCTACTCCCAGG) 및 d(TGGTCTCCTTAAACCTGTCTTG)를 사용하는 것을 제외하고는, 실시예 7A에 기술된 실험을 반복수행하여 pBR328의 262-bp 단편을 수득한다. 반응시간은 사이클당 20분이다.
C. 인체의 베타-글로빈 S 대립인자로부터의 1.9Kb 삽입물을 함유하는 pBR328의
Figure kpo00048
II 분해물 100 펨토몰을 최초의 주형으로 사용하는 것을 제외하고는, 실시예 8B에 기술된 실험을 반복 수행한다. 이 플라스미드를, 증대시킬 서열 내부는 제외하고는,
Figure kpo00049
II로 수회 절단한다. 또한 하기 프라이머 : d(GGTTGGCCAATCTACTCCCAGG) 및 d(TAACCTTGATACCAACCTGCCC)를 사용하여 240-bp단편을 수득한다.
D. pBRr322의 Nru I 분해물 100 펨토몰을 주형으로 사용하고, 각 dNTP 200 나노몰을 반응물 100㎕에 사용하고, 하기 프라이머 : d(TAGGCGTATCACGAGGCCCT) 및 D(CTTCCCCATCGGTGATGTCG)를 사용하는 것을 제외하고는 실시예 7에 기술된 실험을 반복 수행하여 pBR322로부터 500-pb 단편을 수득한다. 반응 시간은 37℃에서 사이클당 20분이다. 최종의 재하이브리드화는 57℃에서 15시간동안 수행한다. 전기영동은 4% 아가로오스 겔 상에서 행한다.
[실시예 9]
이 실시예는 생체의 돌연변이가 증대된 도입되는 본 발명의 방법을 설명하는 것이다.
A. 40mM 트리스(pH 8), 20mM MgCl2, 5mM 디티오트레이틀 및 5㎎/㎖ 소혈청 알부민으로 이루어 전 용액 100㎕중에서, Nru I으로 선형화한 pBr322 100 펨토몰, 75-BP 단편을 생성시킬 하기 프라이머 각 1나노몰 : d(CGCATTAAAGCTTATCGATG) 및 d(TAGGCGTATCACGAGGCCCT) 및 각 dNTP 100 나노몰을 합한다. 혼합물을 1분동안 100℃로 되게 한다음, 23℃의 수욕에서 0.5분동안 냉각시키고, 클레노우단편 4.5 단위 및 무기 피로포스파타제 0.09단위를 가한 후, 반응율 3분동안 진행 시킨다. 가열하여, 냉각시키고, 효소를 가하는 사이클반응을 9회 반복 수행한다. 동결시킴에 의해 10회째 반응 사이클을 종결시킨 후, 반응혼합물 분취량 8㎕를 에티디움 브로마이드로 가시화한 4% 아가로스 겔에 올려 놓는다.
b. 하기 올리고뉴클레오타이드 프라이머: d(CGCATTAAAGCTTATCGATG) 및 d(AATTAATACGACTCACTATAGGGAGATAGGCGTATCACGAGGCCCT)를 사용하는 것을 제외하고는, 실시예 9A에 기술된 실험을 반복 수행한다. 이들 프라이머는 101-bp 단편을 생성시키도록 계획되어 있으며, 두 번째에 기술한 프라이머의 26뉴클레오타이드는 pBR322에는 존재하지 않는다. 이들 뉴클레오타이드는 T7 프로모터의 서열을 나타내는데, 20개의 상보적인 염기 및 26-염기 5' 증대를 갖는 프라이머를 사용하여 pBR322로부터의 75-bp 서열에 부착시킨다. 이 절차를 수행하는 데에는 2시간 미만이 소요되며 pBR322 100펨토몰로부터 비교적 순수한 102-bp 단편 2 피코몰이 생성된다.
T7 프로모터는 RNA 전사를 일으키는데 사용될 수 있다. T7 폴리머라제를 101-bp 단편에 가하여 일본쇄 RNA를 제조할 수도 있다.
C. 하기 올리고뉴클레오타이드 프라이머: d(TAGGCGTATCACGAGGCCCT) 및 d(CCAGCAAGACGTAGCCCAGC)를 사용하는 것을 제외하고는, 실시예 8D에 기술된 실험을 반복 수행하여 pBR322로부터 1000-BP 단편을 수득한다.
d. 하기 올리고뉴클레오타이드 프라이머: D(TAGGCGTATCACGAGGCCCT) 및 d(AATTAATACGACTCACTATAGGAGATAGGCGTATCACGAGGCCCT)를 1026-bp 단편을 제조하기 위해 사용 {여기에서, 두 번째 기술한 프라이머의 26뉴클레오타이드는 pBR322에 존재하지 않으며 상기 기술한 T7 프로모터를 나타낸다}하는 것을 제외하고는, 실시예 9C에 기술된 실험을 반복수행한다. 프로모터는 pBR322로부터 1000-bp 단편에 인접하게 삽입되어 있다.
결과로, 프라이머가 주형 서열에 완전하게 짝을 이루지 않지만, 그럼에도 불구하고 충분히 하이브리드화하여 효소적으로 증대시켜, 상응하는 원 주형의 서열보다 프라이머의 서열을 함유하는 장쇄 생성물을 수득할 수 있음을 알 수 있다. 장쇄 생성물은 두 번째의 프라이머를 위한 주형으로 제공되어 생체내 돌연변이를 유도한다. 추가의 사이클에서 이 돌연변이는, 더 이상의 짝을 못이룬 프라이머는 필요로 하지 않기 때문에, 효율의 감소 없이 증대된다. 이 경우, 그의 5' 말단상에서 비-상보적인 증대를 수반하는프라이머는 새로운 서열을 복제될 주형 서열에 인접한 생성물에 삽입시키는데 사용된다.
E. 폴리머라제의 반응은 피로포스페이트를 생성하며 이론상 가역적이기 때문에 (Komberg, A., DNA Replication, W, H. Freeman, San Francisco, 1980, 잠재적 피로포스포르분해를 방지하기 위해 함유한 무기 피로포스페이트의 효과를 측정하였다. 반응을 더하기 및 빼기 피로포스파타제의 질적 롤리아크릴아미이드겔 전기영동 시험은 이 효소의 함유결과 생성물의 동종서에 작기는 하나 확실한 증가를 입증하였다.
[실시예 10]
이 실시예는 단일 복제 유전자의 증대시 배경을 감소시키기 위해 사용하는 프라이머의 네스트 세트(nested set)를 설명하는 것이다.
야생형 β-글로빈 대립인자에 동형 접합성인 전 인체 DNA를 하기와 같은 증대 사이클을 20회 반복 수행한다 : 300mM 트리스-아세테이트(pH 7.9), 60mM 나트륨 아세테이트, 10mM 디티오트레이톨 및 10mM 마그네슘 아세테이트로 이루어진 용액 100㎕중의, DNA 10㎍ 하기 프라이머 d(ACACAACTGTGTTCACTAGC) 및 d(CAACTTCATCCACGTTCACC) 각 200 피코몰 및 각 dNTP 100나노몰 전체를 100℃로 1분동안 가열한 다음, 25℃로 1분동안 냉각시키고, 2분동안 클레노우 단편 2 단위로 처리한다. 가열하고, 냉각하여 클레노우 단편을 가하는 사이클 반응을 19회 반복 수행한다. 반응 혼합물로부터 분취량 10㎕를 취하여 하기 프라이머:D(CAGACACCATGGTGCACCTGACTCCTG) 및d(CCCCACAGGGCAGTAACGGCAGACTTCTCC) 각각을 사용하여 증대 사이클을 10회 더 반복수행하면, 상기 생성된 110-bp 단편내에 함유되어 있는 58-bp 단편이 증대된다. 이 최종적인 증대 사이클 10회는, 분취량 10㎕를 가가 dNTP 100 나노몰 및 각 프라이머 200 피코몰을 함유하는 상기 기술한 신선한 트리스-아세테이트 완충액 90㎖에 희석시켜 수행한다. 반응 조건은 상기 기술한 바와 같다. 사이클을 10회 수행한 후, 분취량 10㎕(원 DNA 100 나노그람에 사용)를 6% Nusieve(FMC Corp)아가로수겔 상에 올려놓고 에티디움 브로마이드를 사용하여 가시화한다.
제10도는 UV 광을 조사한 후 본 분야에서 알려진 바대로 적색 필터를 통해 사진을 찍은 겔을 설명한 것이다. 레인 1은 분자량 표지물이다. 레인 2는 상기 기술한 반응의 분취량이다. 레인 3은 원래의 야생형 DNA를 증대시키기 전에
Figure kpo00050
I으로 절단한 것을 제외하고는, 상기 기술한 것과 동일한 반응의 분취량이다. 레인 4는 겸상 적혈구 베타글로빈 대립인자에 동형 접합성인 인체 DNA를 증대시키기 전에
Figure kpo00051
I으로 처리(감상 적혈구 대립인자는 여기에서 증대될 단편에서 Dde I 부위를 함유하지 않는다)한 것을 제외하고는, 상기 기술한 것과 동일한 반응의 분취량이다. 레인 5는 연어 정액 DNA를 인체 DNA 대신 사용한 것을 제외하고는, 상기 기술한 것과 동일한 반응의 분취량이다. 레인 6은 분취량을 Dde I으로 처리한 후 증대(
Figure kpo00052
I은 58-bp 야생형 27-bp 및 31-bp 단편으로 전환시킨다) 시킨 것을 제외하고는, 상기 기술한 것과 동일한 반응의 분취량이다. 레인 7은 레인 4 물질을
Figure kpo00053
I으로 처리한 후 증대(58-bp 겸상적혈구 생성무른
Figure kpo00054
I 부위를 함유하지 않는다)시킨 분취량이다.
인체 DNA 1㎍으로부터 단일 복제 유전자의 대표적인 58-bp 단편을 단지 에티디움 브로마이드로 염색한 아가로오스 겔만을 사용하여 탐지하려면 약 500,000배의 증대가 필요하다. 이것은 본 명세서에 기술한 올리고뉴클레오타이드 프라이머의 2개의 네스트 세트를 사용하여 수행한다. 첫 번째 세트는 110-bp 단편을 증대시키고 내부 네스트 세트는 이 생성물의 아-단편을 제10도에서 볼 수 있는, 편리하게 탐지할 수 있는 양까지 증대시킨다. 상기 증대 방법으로 증대될 서열내에 함유되어 있고 다른 프라이머의 증대 생성물에 함유되어 있는 더 짧은 서열을 프라이머를 사용하여 증대시키는 이 방법으로, 하기 문헌[예 : Conner et al.,
Figure kpo00055
: 278(1983) 및 Leary et al., PNAS(USA)
Figure kpo00056
: 4045(1983)]에 기술되어 있는 방사성 동위원소 또는 비-방사성 동위원소 탐침 하이브리드화 방법의 도움없이 베타-글로빈 좌(locus)에서 야생형을 겸상 적혈구 대립인자와 구별할 수 없다.
[실시예 11]
본 발명의 방법은, 환자의 DNA 샘플에서, 예를 들어 클라미디아(chlamydia)와 같은 감염질병에 관련된 특정 서열을 목적하는 증대된 서열을 함유하는 비오티닐화된 하이브리드화 탐침을 사용하여 그리고 상기 미합중국 특허 제4,358,535호에 기술되어 있는 방법을 사용하여 탐지하는데 유용하리라고 기대된다. 비오티닐화된 하이브리드화 탐침은 하기 일반식의 공간 팔(spacer arm)을 통해 비오틴에 결합되어 있는 4'-메틸렌치환 4,5'-8-트리메틸프-소라렌을 갖는 부분적으로 이본쇄인 DNA를 삽입하여 조사(irradation)하여 제조한다.
Figure kpo00057
여기에서 R은 -H 또는 -CHO 그룹이고, R"는 -H이며, X는 1 내지 4의 수이고, y는 2 내지 4의 수이다(EP 156, 287에 기술). 탐침상의 비오티닐 글부의 탐지는 Enzo Bio Chem iNC. 사로부터 상업적으로 수득가능한 스트랩타비딘-산 포스파타제 복합물을 사용하고 제조자에 의해 그의 팜플렛에 제한한 탐지절차를 사용하여 수행할 수 있다. 하이브리드화된 탐침은 탐지 복합물의 결합 및 산 포스파타제에 의해 촉매되는 후속반응(이 반응으로 침전 가능한 염료가 생성된다)에 기인하여 침전된 염색 반점으로 볼 수 있다.
세포라인 SC-1(CTCC #0082)은, ATCC 기탁번호 CRL #87576하에 미합중국 메릴랜드 20852 록크빌 파크로온 드라이브 12301 소재의 아메리칸 타입 컬춰 콜렉션(American Type culture Collection : ATCC)에 1985년 3월 19일자로 기탁하였다. SC-1의 기탁은 ATCC와 이 특허출원의 서명자인 세투스 코포레이션사와의 게약에 의한 것이다.
ATCC와의 약정은 기탁을 기술하고 입증하는 미합중국 특허의 공표시, 또는 미합중국 또는 외국 특허원의 공개시 어느 것이 먼저든 이 세포라인의 후속을 영구히 공개하며, 35 CFR §122 및 2에 의한 청장 규정에 따라(특히 886 OG 638에 관한 37 CFR § 1.14포함) 미합중국 특허 및 상표청장에 의해 권한을 받은 자에게 이 세포라인의 후손을 분양하는 것이다. 본 출원의 서명자는 만약 기탁된 세포주가 적당한 조건하에 배양시 죽거나 분실 또는 파괴할 경우, 즉시 동일 세포주의 생존 배양물로 공식대치할 것이다.
개략적으로, 본 발명은 프라이머 증대 생성물을 제조하고, 이것은 후속적으로 또다른 프라이머 증대 반응시 주형으로 작용할 수 있는 연쇄 반응을 이용하여 1개 또는 그 이상 특정 핵산 서열을 증대시키는 방법을 제공하고 있다. 본 방법은 초기에 아주 소량으로 존재하는 핵산 서열을 검출하는데 특히 유용하다.

Claims (10)

  1. (a) 하나의 프라이머로부터 합성된 증대 생성물이 이의 상보서열로부터 분리될 경우 다른 프라이머의 증대 생성물을 합성하기 위한 주형으로 작용할 수 있을 정도로 각각 특징 서열의 상이한 본쇄에 상당히 상보적인 것으로 선택된, 각각의 상이한 특정 서열의 증대를 위한 두 개의 올리고뉴클레오타이드 프라이머를, 각각의 핵산 본쇄에 상보적인 각 프라이머의 증대 생성물이 각각의 상이한 서열의 증대를 위해 합성될 수 있는 조건하에서, 본쇄에 처리하고 ; (b) 주형상에서 합성된 프라이머 증대 생성물을 주형으로부터 분리하여 일본쇄 분자를 제조하며 ; (c) 단계(b)에서 제조된 각각의 일본쇄 분자를 주형으로 사용하여 프라이머 증대 생성물을 합성하는 조건하에서, 단계(b)에서 제조된 일본쇄 분자를 단계(a)의프라이머로 처리함을 특징으로 하여, 길이가 동일하거나 상이한 두 개의 분리된 상보 본쇄로 이루어진 핵산 또는 핵산들의 혼합물내에 포함된 하나이상의 특정 핵산 서열을 증대시키는 방법.
  2. 제1항에 있어서, 단계(b) 및 (c)를 일회이상 반복하는 방법.
  3. 제1항 또는 2항에 있어서, 단계(b)를 변성방법 또는 효소 헬리카제(helicase)를 사용하여 수행하고, 단계 (a) 및 (c)를 중합반응 유도제 및 4개의 상이한 뉴클레오타이드를 사용하여 수행하는 방법.
  4. 제1항에 있어서, 단계(a) 및 (c)를 이. 콜라이 DNA 폴리머라제 I, 이. 콜라이 DNA 폴리머라제 I의 클레노우 단편(Klenow fragment), T4DNA 폴리머라제, 내열성 효소 및 역전사 효소중에서 선택된 중합반응 유도제를 사용하여 수행하는 방법.
  5. 제1항에 있어서, 핵산이 DNA이고 프라이머가 올리고데옥시리보뉴클레오타이드인 방법.
  6. 제1항에 있어서, 핵산이
    Figure kpo00058
    RNA이고, 각 상보 본쇄에 대해 한 집단의 프라이머를 사용하며, 이들 프라이머중 하나가 상보 본쇄와 100% 상동성인 방법.
  7. 제1항에 있어서, 단계(a)에서 사용된 핵산들의 혼합물이 단계(c)에 의해 제조된 선행증대 방법의 생성물인 방법.
  8. 제7항에 있어서, 사용된 프라이머가 선행증대 방법에서 사용된 프라이머와 상이한 방법.
  9. 제1항에 있어서, 하나의 프라이머가 증대될 특정 서열에 대해 비상보적인 하나이상의 뉴클레이타오드를 포함하는 방법.
  10. 제1항에 있어서, 단계 (a) 및 (c)에서 사용된 2개의 프라이머가 적어도 1000 : 1의 프라이머 : 상보본쇄의 몰비로 각각 존재하는 방법.
KR1019860002332A 1985-03-28 1986-03-28 핵산 서열의 증대 방법 KR900008742B1 (ko)

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Families Citing this family (6322)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4957858A (en) * 1986-04-16 1990-09-18 The Salk Instute For Biological Studies Replicative RNA reporter systems
CA1278755C (en) * 1985-03-15 1991-01-08 William J. Knowles Labelling of oligonucleotides
US5386022A (en) * 1985-03-28 1995-01-31 Hoffman-La Roche Inc. Primes and probes for the amplification and detection of aids associated nucleic acids
US5656493A (en) * 1985-03-28 1997-08-12 The Perkin-Elmer Corporation System for automated performance of the polymerase chain reaction
US6197563B1 (en) 1985-03-28 2001-03-06 Roche Molecular Systems, Inc. Kits for amplifying and detecting nucleic acid sequences
AU606043B2 (en) * 1985-03-28 1991-01-31 F. Hoffmann-La Roche Ag Detection of viruses by amplification and hybridization
US6040166A (en) 1985-03-28 2000-03-21 Roche Molecular Systems, Inc. Kits for amplifying and detecting nucleic acid sequences, including a probe
US5333675C1 (en) * 1986-02-25 2001-05-01 Perkin Elmer Corp Apparatus and method for performing automated amplification of nucleic acid sequences and assays using heating and cooling steps
US5176995A (en) * 1985-03-28 1993-01-05 Hoffmann-La Roche Inc. Detection of viruses by amplification and hybridization
US4965188A (en) * 1986-08-22 1990-10-23 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
US5635389A (en) * 1985-05-02 1997-06-03 Institut Pasteur Antibodies which recognize and bind human villin
US4822731A (en) * 1986-01-09 1989-04-18 Cetus Corporation Process for labeling single-stranded nucleic acids and hybridizaiton probes
US6344315B1 (en) 1986-01-16 2002-02-05 The Regents Of The University Of California Chromosome-specific staining to detect genetic rearrangements associated with chromosome 3 and/or chromosome 17
US6475720B1 (en) 1986-01-16 2002-11-05 The Regents Of The University Of California Chromosome-specific staining to detect genetic rearrangements associated with chromosome 3 and/or chromosome 17
US5447841A (en) * 1986-01-16 1995-09-05 The Regents Of The Univ. Of California Methods for chromosome-specific staining
US5756696A (en) 1986-01-16 1998-05-26 Regents Of The University Of California Compositions for chromosome-specific staining
US5721098A (en) * 1986-01-16 1998-02-24 The Regents Of The University Of California Comparative genomic hybridization
US7115709B1 (en) * 1986-01-16 2006-10-03 The Regents Of The University Of California Methods of staining target chromosomal DNA employing high complexity nucleic acid probes
US6872817B1 (en) 1986-01-16 2005-03-29 The Regents Of The Univ. Of California Method of staining target interphase chromosomal DNA
US6280929B1 (en) 1986-01-16 2001-08-28 The Regents Of The University Of California Method of detecting genetic translocations identified with chromosomal abnormalities
US4800159A (en) * 1986-02-07 1989-01-24 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences
CA1339653C (en) * 1986-02-25 1998-02-03 Larry J. Johnson Appartus and method for performing automated amplification of nucleic acid sequences and assays using heating and cooling steps
US6194561B1 (en) 1986-03-13 2001-02-27 Roche Molecular Systems, Inc. Characterization and detection of sequences associated with autoimmune diseases
CA1284931C (en) * 1986-03-13 1991-06-18 Henry A. Erlich Process for detecting specific nucleotide variations and genetic polymorphisms present in nucleic acids
US5310893A (en) * 1986-03-31 1994-05-10 Hoffmann-La Roche Inc. Method for HLA DP typing
US5604099A (en) * 1986-03-13 1997-02-18 Hoffmann-La Roche Inc. Process for detecting specific nucleotide variations and genetic polymorphisms present in nucleic acids
GB8606719D0 (en) 1986-03-19 1986-04-23 Lister Preventive Med Genetic probes
US5356774A (en) * 1986-04-16 1994-10-18 The Trustees Of Columbia University In The City Of New York Replicative RNA-based amplification/detection systems
US5635347A (en) * 1986-04-30 1997-06-03 Igen, Inc. Rapid assays for amplification products
US4851331A (en) * 1986-05-16 1989-07-25 Allied Corporation Method and kit for polynucleotide assay including primer-dependant DNA polymerase
US5215914A (en) * 1986-06-18 1993-06-01 American Registry Of Pathology Adherent and invasive mycoplasma
US7384735B1 (en) 1986-08-11 2008-06-10 Massachusetts Eye And Ear Infirmary Retinoblastoma nucleic acids
AU632857C (en) * 1986-08-22 2003-10-09 F. Hoffmann-La Roche Ag Purified thermostable enzyme
US5795762A (en) * 1986-08-22 1998-08-18 Roche Molecular Systems, Inc. 5' to 3' exonuclease mutations of thermostable DNA polymerases
US5407800A (en) * 1986-08-22 1995-04-18 Hoffmann-La Roche Inc. Reverse transcription with Thermus thermophilus polymerase
US5079352A (en) * 1986-08-22 1992-01-07 Cetus Corporation Purified thermostable enzyme
US5310652A (en) * 1986-08-22 1994-05-10 Hoffman-La Roche Inc. Reverse transcription with thermostable DNA polymerase-high temperature reverse transcription
US4889818A (en) * 1986-08-22 1989-12-26 Cetus Corporation Purified thermostable enzyme
US5322770A (en) * 1989-12-22 1994-06-21 Hoffman-Laroche Inc. Reverse transcription with thermostable DNA polymerases - high temperature reverse transcription
US5466591A (en) * 1986-08-22 1995-11-14 Hoffmann-La Roche Inc. 5' to 3' exonuclease mutations of thermostable DNA polymerases
US5618711A (en) * 1986-08-22 1997-04-08 Hoffmann-La Roche Inc. Recombinant expression vectors and purification methods for Thermus thermophilus DNA polymerase
US5714380A (en) 1986-10-23 1998-02-03 Amoco Corporation Closed vessel for isolating target molecules and for performing amplification
US5079351A (en) * 1986-11-26 1992-01-07 Cetus Corporation Oligonucleotides and kits for detection of htlvi and htlvii viruses by hybridization
US5268268A (en) * 1986-11-26 1993-12-07 Hoffmann-La Roche Inc. Detection of HTLVI and HTLVII viruses by hybridization
US5145776A (en) * 1987-01-14 1992-09-08 President & Fellows Of Harvard College Method of using T7 DNA polymerase to mutagenize and fill-in DNA
US4921794A (en) * 1987-01-14 1990-05-01 President And Fellows Of Harvard College T7 DNA polymerase
US5266466A (en) * 1987-01-14 1993-11-30 President And Fellows Of Harvard College Method of using T7 DNA polymerase to label the 3' end of a DNA molecule
US4942130A (en) * 1987-01-14 1990-07-17 President & Fellows Of Harvard College T7 DNA polymerase
US4946786A (en) * 1987-01-14 1990-08-07 President And Fellows Of Harvard College T7 DNA polymerase
KR880010128A (ko) * 1987-02-12 1988-10-07 나카사와 다로 단쇄 dna의 조제방법
JP3096704B2 (ja) 1987-02-26 2000-10-10 バイオサーチ インターナショナル ピティ リミテッド ヒトの発癌性乳頭腫ウイルスの検出方法
AU622104B2 (en) * 1987-03-11 1992-04-02 Sangtec Molecular Diagnostics Ab Method of assaying of nucleic acids, a reagent combination and kit therefore
US5525464A (en) * 1987-04-01 1996-06-11 Hyseq, Inc. Method of sequencing by hybridization of oligonucleotide probes
US5202231A (en) * 1987-04-01 1993-04-13 Drmanac Radoje T Method of sequencing of genomes by hybridization of oligonucleotide probes
NO881560L (no) * 1987-05-05 1988-11-07 Hope City Fremgangsmaate for detektering av begynnende resistens motterapeutiske midler i kreftpasienter.
IL86724A (en) * 1987-06-19 1995-01-24 Siska Diagnostics Inc Methods and kits for amplification and testing of nucleic acid sequences
DE3721400A1 (de) * 1987-06-29 1989-01-12 Viktor Dr Dr Med Balazs Verfahren zur untersuchung einer azellularen biologischen fluessigkeit auf zellulare onkogen-dna bzw. deren fragmente
US5273879A (en) * 1987-07-23 1993-12-28 Syntex (U.S.A.) Inc. Amplification method for polynucleotide assays
US4994368A (en) * 1987-07-23 1991-02-19 Syntex (U.S.A.) Inc. Amplification method for polynucleotide assays
JP2774121B2 (ja) * 1987-07-31 1998-07-09 ザ ボード オブ トラスティーズ オブ ザ リーランド スタンフォード ジュニア ユニバーシティ 標的ポリヌクレオチド配列の選択的増幅
AU618965B2 (en) * 1987-07-31 1992-01-16 Board Of Trustees Of The Leland Stanford Junior University Selective amplification of target polynucleotide sequences
US6090591A (en) * 1987-07-31 2000-07-18 The Board Of Trustees Of The Leland Stanford Junior University Selective amplification of target polynucleotide sequences
DE3726934A1 (de) * 1987-08-13 1989-02-23 Merck Patent Gmbh Verfahren zum nachweis von nukleinsaeure-sequenzen
US5137829A (en) * 1987-10-05 1992-08-11 Washington University DNA transposon TN5SEQ1
US5212080A (en) * 1987-10-05 1993-05-18 Washington University Method of DNA sequencing using DNA transposon Tn5seql
US5359100A (en) * 1987-10-15 1994-10-25 Chiron Corporation Bifunctional blocked phosphoramidites useful in making nucleic acid mutimers
US5124246A (en) * 1987-10-15 1992-06-23 Chiron Corporation Nucleic acid multimers and amplified nucleic acid hybridization assays using same
US6171782B1 (en) 1987-11-18 2001-01-09 Chiron Corporation Antibody compositions to HCV and uses thereof
US6861212B1 (en) 1987-11-18 2005-03-01 Chiron Corporation NANBV diagnostics and vaccines
US5714596A (en) * 1987-11-18 1998-02-03 Chiron Corporation NANBV diagnostics: polynucleotides useful for screening for hepatitis C virus
US5712088A (en) * 1987-11-18 1998-01-27 Chiron Corporation Methods for detecting Hepatitis C virus using polynucleotides specific for same
US5698390A (en) * 1987-11-18 1997-12-16 Chiron Corporation Hepatitis C immunoassays
US5350671A (en) * 1987-11-18 1994-09-27 Chiron Corporation HCV immunoassays employing C domain antigens
US4902624A (en) * 1987-11-23 1990-02-20 Eastman Kodak Company Temperature cycling cuvette
FI79342C (fi) * 1987-12-23 1989-12-11 Orion Yhtymae Oy Apparat, del av en apparat och foerfarande foer maongfaldigande av nukleinsyror.
US5449602A (en) * 1988-01-13 1995-09-12 Amoco Corporation Template-directed photoligation
US6027913A (en) * 1988-01-28 2000-02-22 Sommer; Steven S. Nucleic acid amplification with direct sequencing
EP0358737A4 (en) * 1988-01-28 1992-04-08 Mayo Foundation For Medical Education And Research Genomic amplification with direct sequencing
JP2650159B2 (ja) * 1988-02-24 1997-09-03 アクゾ・ノベル・エヌ・ベー 核酸増幅方法
CA1340807C (en) * 1988-02-24 1999-11-02 Lawrence T. Malek Nucleic acid amplification process
IE61148B1 (en) * 1988-03-10 1994-10-05 Ici Plc Method of detecting nucleotide sequences
US5024934A (en) * 1988-03-14 1991-06-18 The Board Of Regents, The University Of Texas System Detection of minimal numbers of neoplastic cells carrying DNA translocations by DNA sequence amplification
ATE108491T1 (de) * 1988-03-18 1994-07-15 Baylor College Medicine Mutationsnachweis durch kompetitiven oligonukleotid-priming.
JP2856804B2 (ja) * 1988-03-24 1999-02-10 ユニバーシティ オブ アイオワ リサーチ ファウンデイション 標識された相補的核酸プローブを開裂する触媒反応の補因子としての活性に基づく核酸配列検出のための触媒ハイブリッド形成系
US5614620A (en) * 1988-03-30 1997-03-25 Arch Development Corporation DNA binding proteins including androgen receptor
US4999290A (en) * 1988-03-31 1991-03-12 The Board Of Regents, The University Of Texas System Detection of genomic abnormalities with unique aberrant gene transcripts
CA1341584C (en) * 1988-04-06 2008-11-18 Bruce Wallace Method of amplifying and detecting nucleic acid sequences
ATE114726T1 (de) * 1988-05-10 1994-12-15 Du Pont Verfahren zum schnellen nachweis von nukleinsäuren.
US5817797A (en) * 1988-06-01 1998-10-06 The United States Of America As Represented By The Department Of Health And Human Services Sequencing DNA; a modification of the polymerase chain reaction
AU3748489A (en) * 1988-06-17 1990-01-12 Genelabs Incorporated Enterically transmitted non-a/non-b hepatitis viral agent
US5130238A (en) * 1988-06-24 1992-07-14 Cangene Corporation Enhanced nucleic acid amplification process
US5498523A (en) * 1988-07-12 1996-03-12 President And Fellows Of Harvard College DNA sequencing with pyrophosphatase
US4962020A (en) * 1988-07-12 1990-10-09 President And Fellows Of Harvard College DNA sequencing
AU632760B2 (en) * 1988-07-26 1993-01-14 Genelabs Technologies, Inc. Rna and dna amplification techniques
AU3974989A (en) * 1988-07-26 1990-02-19 Genelabs Incorporated Sequence-specific amplification techniques
AU4181089A (en) * 1988-08-01 1990-03-05 George D. Cimino Identification of allele specific nucleic acid sequences by hybridization with crosslinkable oligonucleotide probes
US5382511A (en) * 1988-08-02 1995-01-17 Gene Tec Corporation Method for studying nucleic acids within immobilized specimens
US5523205A (en) * 1988-08-02 1996-06-04 Institut Pasteur DNA probes specific for hemolytic listeria
AU4194089A (en) * 1988-08-08 1990-03-05 Cetus Corporation Methods for isolating herpes virus thymidine kinase-encoding dna
US5324664A (en) * 1988-08-08 1994-06-28 The Upjohn Company Herpes virus thymidien kinase-encoding DNA
US5760203A (en) * 1988-08-10 1998-06-02 Chiron Corporation Gap gene sequences
US5763573A (en) * 1988-08-10 1998-06-09 Chiron Corporation GTPase activating protein fragments
US5223409A (en) * 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
FR2636075B1 (fr) * 1988-09-07 1991-11-15 Biotechnologie Ste Europ Procede de detection des bacteries, levures, parasites et autres eucaryotes, notamment dans les produits alimentaires
CA1339991C (en) * 1988-09-08 1998-08-11 The Trustees Of Columbia University Replicative rna-based amplification/detection system
US5447839A (en) * 1988-09-09 1995-09-05 Hoffmann-La Roche Inc. Detection of human papillomavirus by the polymerase chain reaction
US5132215A (en) * 1988-09-15 1992-07-21 Eastman Kodak Company Method of making double-stranded dna sequences
US5091310A (en) * 1988-09-23 1992-02-25 Cetus Corporation Structure-independent dna amplification by the polymerase chain reaction
US5075216A (en) * 1988-09-23 1991-12-24 Cetus Corporation Methods for dna sequencing with thermus aquaticus dna polymerase
US5066584A (en) * 1988-09-23 1991-11-19 Cetus Corporation Methods for generating single stranded dna by the polymerase chain reaction
US5142033A (en) * 1988-09-23 1992-08-25 Hoffmann-La Roche Inc. Structure-independent DNA amplification by the polymerase chain reaction
US5118801A (en) * 1988-09-30 1992-06-02 The Public Health Research Institute Nucleic acid process containing improved molecular switch
US6641999B1 (en) 1988-10-19 2003-11-04 The Dow Chemical Company Probing method for identifying antibodies specific for selected antigens
JP2781438B2 (ja) * 1988-10-20 1998-07-30 モーリィ，アリグザンダー，アラン 白血病及びリンパ腫におけるモノクローナリテイーの診断法
US5077192A (en) * 1988-10-25 1991-12-31 The General Hospital Corporation Method of detecting antigenic, nucleic acid-containing macromolecular entities
FR2638464B1 (fr) * 1988-10-28 1992-01-03 Pasteur Institut Fragments d'acide nucleique specifiques du gene de la villine humaine, leur utilisation aux fins de diagnostic
AU634186B2 (en) * 1988-11-11 1993-02-18 Medical Research Council Single domain ligands, receptors comprising said ligands, methods for their production, and use of said ligands and receptors
US6277591B1 (en) 1988-11-18 2001-08-21 Oregon Health Science University Dopamine receptors and genes
CA2001110A1 (en) * 1988-11-18 1990-05-18 Zvi G. Loewy Compositions and process for amplifying and detecting nucleic acid sequences
US5759820A (en) * 1988-11-21 1998-06-02 Dynal As Process for producing cDNA
US5489507A (en) * 1988-11-30 1996-02-06 Perkin-Elmer Corporation DNA detection by color complementation
ZA899593B (en) * 1988-12-16 1990-09-26 Siska Diagnostics Inc Self-sustained,sequence replication system
FR2641792A1 (fr) * 1988-12-28 1990-07-20 Pasteur Institut Sequences de nucleotides codant pour la calmoduline chez l'homme et leurs applications biologiques
US4983511A (en) * 1989-01-09 1991-01-08 Olin Corporation Method and kit for detecting live microorganisms in chlorine- or bromine-treated water
CA2008096A1 (en) * 1989-01-19 1990-07-19 Samuel Rose Nucleic acid amplification using single primer
JPH04504356A (ja) * 1989-01-31 1992-08-06 ユニバーシティ オブ マイアミ 染色体ｄｎａの顕微解剖と増幅
US5514550A (en) * 1989-02-03 1996-05-07 Johnson & Johnson Clinical Diagnostics, Inc. Nucleic acid test article and its use to detect a predetermined nucleic acid
GB8902689D0 (en) * 1989-02-07 1989-03-30 Ici Plc Assay method
CA2046919A1 (en) * 1989-02-14 1990-08-15 Mark P. Pasek Oligonucleotide primer pairs for sequence independent gene amplification and methods which employ them
US5380645A (en) * 1989-03-16 1995-01-10 The Johns Hopkins University Generalized method for assessment of colorectal carcinoma
US5001050A (en) * 1989-03-24 1991-03-19 Consejo Superior Investigaciones Cientificas PHφ29 DNA polymerase
CA2012983A1 (en) * 1989-03-27 1990-09-27 Sydney Brenner Process for nucleic acid detection by binary amplification
US5075212A (en) * 1989-03-27 1991-12-24 University Of Patents, Inc. Methods of detecting picornaviruses in biological fluids and tissues
CA2012984A1 (en) * 1989-03-27 1990-09-27 Frank W. Hobbs Jr. Process for rapid nucleic acid detection by incorporating a reporter moiety into amplified target nucleic acid followed by affinity capture
US5527676A (en) * 1989-03-29 1996-06-18 The Johns Hopkins University Detection of loss of the wild-type P53 gene and kits therefor
US5284760A (en) * 1989-04-03 1994-02-08 Feinstone Stephen M Techniques for producing site-directed mutagenesis of cloned DNA
FR2645877B1 (fr) * 1989-04-12 1991-07-05 Pasteur Institut Molecules comportant au moins une sequence peptidique porteuse d'un, ou plusieurs, epitope caracteristique d'une proteine produite par p. falciparum au niveau du stade sporozoite et dans les hepatocytes
KR920700294A (ko) * 1989-04-12 1992-02-19 원본미기재 개선된 프라이머 연장반응
US5334499A (en) * 1989-04-17 1994-08-02 Eastman Kodak Company Methods of extracting, amplifying and detecting a nucleic acid from whole blood or PBMC fraction
CA2013317A1 (en) * 1989-04-17 1990-10-17 Fred T. Oakes Diagnostic kit, primer composition and their use for replication or detection of nucleic acids
US6027729A (en) * 1989-04-20 2000-02-22 Chiron Corporation NANBV Diagnostics and vaccines
US5075217A (en) * 1989-04-21 1991-12-24 Marshfield Clinic Length polymorphisms in (dC-dA)n ·(dG-dT)n sequences
US5043272A (en) * 1989-04-27 1991-08-27 Life Technologies, Incorporated Amplification of nucleic acid sequences using oligonucleotides of random sequence as primers
US5106727A (en) * 1989-04-27 1992-04-21 Life Technologies, Inc. Amplification of nucleic acid sequences using oligonucleotides of random sequences as primers
IE66597B1 (en) * 1989-05-10 1996-01-24 Akzo Nv Method for the synthesis of ribonucleic acid (RNA)
CA2016518A1 (en) * 1989-05-11 1990-11-11 Peter Baram Nucleic acid based diagnostic system and process for the detection of pneumocystis carinii in blood products
US6291159B1 (en) 1989-05-16 2001-09-18 Scripps Research Institute Method for producing polymers having a preselected activity
US6291160B1 (en) 1989-05-16 2001-09-18 Scripps Research Institute Method for producing polymers having a preselected activity
US6680192B1 (en) 1989-05-16 2004-01-20 Scripps Research Institute Method for producing polymers having a preselected activity
US6291158B1 (en) 1989-05-16 2001-09-18 Scripps Research Institute Method for tapping the immunological repertoire
US6291161B1 (en) 1989-05-16 2001-09-18 Scripps Research Institute Method for tapping the immunological repertiore
GR1002158B (en) * 1989-05-16 1996-02-23 Stratagene Inc Method for tapping the immunological repertoire
US6969586B1 (en) 1989-05-16 2005-11-29 Scripps Research Institute Method for tapping the immunological repertoire
GR1002149B (en) * 1989-05-16 1996-02-20 Scripps Clinic Res Method for producing polymers having a preselected activity
AU638719B2 (en) * 1989-05-18 1993-07-08 Novartis Vaccines And Diagnostics, Inc. Nanbv diagnostics: polynucleotides useful for screening for hepatitis c virus
JP3082942B2 (ja) * 1989-05-22 2000-09-04 エフ・ホフマンーラ ロシュ アーゲー 核酸による物質の標識及び追跡方法
US5112734A (en) * 1989-05-26 1992-05-12 Gene-Trak Systems Target-dependent synthesis of an artificial gene for the synthesis of a replicatable rna
US5683896A (en) 1989-06-01 1997-11-04 Life Technologies, Inc. Process for controlling contamination of nucleic acid amplification reactions
US5035996A (en) * 1989-06-01 1991-07-30 Life Technologies, Inc. Process for controlling contamination of nucleic acid amplification reactions
US5279938A (en) * 1989-06-05 1994-01-18 The United States Of America As Represented By The Department Of Health And Human Services Sensitive diagnostic test for lyme disease
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US6040138A (en) 1995-09-15 2000-03-21 Affymetrix, Inc. Expression monitoring by hybridization to high density oligonucleotide arrays
US5744101A (en) 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
US6551784B2 (en) 1989-06-07 2003-04-22 Affymetrix Inc Method of comparing nucleic acid sequences
US6955915B2 (en) 1989-06-07 2005-10-18 Affymetrix, Inc. Apparatus comprising polymers
US6346413B1 (en) 1989-06-07 2002-02-12 Affymetrix, Inc. Polymer arrays
US6406844B1 (en) 1989-06-07 2002-06-18 Affymetrix, Inc. Very large scale immobilized polymer synthesis
US5800992A (en) 1989-06-07 1998-09-01 Fodor; Stephen P.A. Method of detecting nucleic acids
US6309822B1 (en) 1989-06-07 2001-10-30 Affymetrix, Inc. Method for comparing copy number of nucleic acid sequences
US6919211B1 (en) 1989-06-07 2005-07-19 Affymetrix, Inc. Polypeptide arrays
US6416952B1 (en) 1989-06-07 2002-07-09 Affymetrix, Inc. Photolithographic and other means for manufacturing arrays
DE69003104T2 (de) * 1989-06-12 1994-03-17 Cis Bio International Saclay Verfahren zum nachweis von spezifischen sequenzen von nukleinsäuren und ihre verwendungen.
US5055393A (en) * 1989-06-13 1991-10-08 Salk Institute Biotechnology/Industrial Associates, Inc. Prenatal sex determination of bovine cells using male-specific oligonucleotides
US5045449A (en) * 1989-06-14 1991-09-03 Thomas Jefferson University Methods of detecting a genetic predisposition for vascular aneurysms
EP0406937A3 (en) * 1989-06-30 1992-01-22 Eastman Kodak Company In vitro gene synthesis
US5766849A (en) * 1989-07-11 1998-06-16 Gen-Probe Incorporated Methods of amplifying nucleic acids using promoter-containing primer sequence
US6589734B1 (en) 1989-07-11 2003-07-08 Gen-Probe Incorporated Detection of HIV
CA2020958C (en) * 1989-07-11 2005-01-11 Daniel L. Kacian Nucleic acid sequence amplification methods
ATE282716T1 (de) * 1989-07-11 2004-12-15 Gen Probe Inc Verfahren zur amplifikation von nukleinsäuresequenzen
EP0409159B1 (en) * 1989-07-18 1998-11-25 Shimadzu Corporation Method for testing causative microorganism of food poisoning and reagents therefor
US5219739A (en) * 1989-07-27 1993-06-15 Scios Nova Inc. DNA sequences encoding bVEGF120 and hVEGF121 and methods for the production of bovine and human vascular endothelial cell growth factors, bVEGF120 and hVEGF121
US5124041A (en) * 1989-07-28 1992-06-23 Applied Biosystems, Inc. Biomolecule sample immobilization
US5550318A (en) * 1990-04-17 1996-08-27 Dekalb Genetics Corporation Methods and compositions for the production of stably transformed, fertile monocot plants and cells thereof
US7705215B1 (en) 1990-04-17 2010-04-27 Dekalb Genetics Corporation Methods and compositions for the production of stably transformed, fertile monocot plants and cells thereof
US6803499B1 (en) 1989-08-09 2004-10-12 Dekalb Genetics Corporation Methods and compositions for the production of stably transformed, fertile monocot plants and cells thereof
US5023171A (en) * 1989-08-10 1991-06-11 Mayo Foundation For Medical Education And Research Method for gene splicing by overlap extension using the polymerase chain reaction
US5843693A (en) * 1989-08-16 1998-12-01 Chiron Corporation Assay method for screening for inhibitors of proTNF conversion
US5998378A (en) * 1989-08-16 1999-12-07 Chiron Corporation Compositions for the inhibition of TNF hormone formation and uses thereof
US6586222B1 (en) 1989-08-16 2003-07-01 Chiron Corporation Recombinant PR-3 and compositions thereof
US5219727A (en) * 1989-08-21 1993-06-15 Hoffmann-Laroche Inc. Quantitation of nucleic acids using the polymerase chain reaction
US20040197775A1 (en) * 1989-08-25 2004-10-07 Genetype A.G. Intron sequence analysis method for detection of adjacent and remote locus alleles as haplotypes
US5213961A (en) * 1989-08-31 1993-05-25 Brigham And Women's Hospital Accurate quantitation of RNA and DNA by competetitive polymerase chain reaction
US7413537B2 (en) * 1989-09-01 2008-08-19 Dyax Corp. Directed evolution of disulfide-bonded micro-proteins
DE3929030A1 (de) * 1989-09-01 1991-03-07 Boehringer Mannheim Gmbh Verfahren zur vermehrung von nukleinsaeuren
DK0490951T3 (da) * 1989-09-06 1996-08-26 Pasteur Institut Nucleinsyrefragmenter fra en genom fra en egnet mycobakterie, deres anvendelse til diagnose af mycobakterieinfektioner samt plasmider indeholdende disse fragmenter
US5438126A (en) * 1989-09-11 1995-08-01 Arch Development Corporation Human thyroid hormone receptor DNA
US5196305A (en) * 1989-09-12 1993-03-23 Eastman Kodak Company Diagnostic and amplification methods using primers having thymine at 3' end to overcome primer-target mismatch at the 3' end
JP3156200B2 (ja) 1989-09-15 2001-04-16 国立予防衛生研究所長 新規のｈｃｖ分離株
US5545522A (en) * 1989-09-22 1996-08-13 Van Gelder; Russell N. Process for amplifying a target polynucleotide sequence using a single primer-promoter complex
ATE168416T1 (de) * 1989-10-05 1998-08-15 Optein Inc Zellfreie synthese und isolierung von genen und polypeptiden
WO1991006009A1 (en) * 1989-10-16 1991-05-02 Amgen Inc. N-acetylmuramidase m1
US5139940A (en) * 1989-10-26 1992-08-18 Isaacs Stephen T Activation compounds and methods of synthesis of activation compounds
US5503721A (en) 1991-07-18 1996-04-02 Hri Research, Inc. Method for photoactivation
US5532145A (en) * 1989-10-26 1996-07-02 Steritech, Inc. Methods for treatment of enzyme preparations
US6007984A (en) * 1989-11-01 1999-12-28 Zeneca Limited Detection of DNA/RNA by fluorescence polarization
US5863717A (en) * 1989-11-03 1999-01-26 Abbott Laboratories Use of conserved oligonucleotide primers to amplify human papillomavirus DNA sequences
WO1991007506A1 (en) * 1989-11-08 1991-05-30 The United States Of America, Represented By The Secretary, United States Department Of Commerce A method of synthesizing double-stranded dna molecules
WO1991007502A1 (en) * 1989-11-08 1991-05-30 Baylor College Of Medicine Methods and reagents to detect and characterize norwalk and related viruses
US5215899A (en) * 1989-11-09 1993-06-01 Miles Inc. Nucleic acid amplification employing ligatable hairpin probe and transcription
US5183884A (en) * 1989-12-01 1993-02-02 United States Of America Dna segment encoding a gene for a receptor related to the epidermal growth factor receptor
DE4001154A1 (de) * 1990-01-17 1991-07-18 Boehringer Mannheim Gmbh Verfahren zur herstellung von modifizierten nukleinsaeuren
CA2033718A1 (en) * 1990-01-19 1991-07-20 Ronald M. Atlas Process for detection of water-borne microbial pathogens and indicators of human fecal contamination in water samples and kits therefor
US6329574B1 (en) * 1990-01-22 2001-12-11 Dekalb Genetics Corporation High lysine fertile transgenic corn plants
US6946587B1 (en) * 1990-01-22 2005-09-20 Dekalb Genetics Corporation Method for preparing fertile transgenic corn plants
US5484956A (en) * 1990-01-22 1996-01-16 Dekalb Genetics Corporation Fertile transgenic Zea mays plant comprising heterologous DNA encoding Bacillus thuringiensis endotoxin
US6777589B1 (en) * 1990-01-22 2004-08-17 Dekalb Genetics Corporation Methods and compositions for the production of stably transformed, fertile monocot plants and cells thereof
CA2074355C (en) * 1990-01-22 2008-10-28 Ronald C. Lundquist Method of producing fertile transgenic corn plants
US6025545A (en) * 1990-01-22 2000-02-15 Dekalb Genetics Corporation Methods and compositions for the production of stably transformed, fertile monocot plants and cells thereof
WO1991011534A1 (en) * 1990-01-24 1991-08-08 The United States Of America, As Represented By The Secretary, U.S. Department Of Commerce A rapid and sensitive test for detecting hepatitis a virus
KR950013953B1 (ko) * 1990-01-26 1995-11-18 애보트 래보라토리즈 리가제 연쇄 반응에 적용가능한 표적 핵산의 증폭 방법
US6013431A (en) * 1990-02-16 2000-01-11 Molecular Tool, Inc. Method for determining specific nucleotide variations by primer extension in the presence of mixture of labeled nucleotides and terminators
CA2075050C (en) * 1990-02-16 1998-10-06 Will Bloch Specificity and convenience of the polymerase chain reaction
US5049490A (en) * 1990-02-20 1991-09-17 Eastman Kodak Co. Quantitative determination of a DNA polymerase and a test kit useful in same
CA2076853A1 (en) 1990-02-26 1991-08-27 Stephen H. Hughes Method for the fluorescent detection of a dna sequence in real time
US5200314A (en) * 1990-03-23 1993-04-06 Chiron Corporation Polynucleotide capture assay employing in vitro amplification
US7070776B1 (en) 1990-03-26 2006-07-04 Bristol-Myers Squibb Company Methods for blocking binding of CD28 receptor to B7
US5580756A (en) 1990-03-26 1996-12-03 Bristol-Myers Squibb Co. B7Ig fusion protein
US20030219446A1 (en) * 1990-03-26 2003-11-27 Bristol-Myers Squibb Company Ligand for CD28 receptor on B cells and methods
WO1991015599A1 (en) * 1990-04-05 1991-10-17 Amrad Corporation Limited A method for detecting dna
DK0527815T3 (da) * 1990-04-06 2000-11-06 Genelabs Tech Inc Hepatitis C-virus-epitop
US5198337A (en) * 1990-04-13 1993-03-30 State Of Oregon Assay for gene deletion of GST-1 in human samples based on the polymerase chain reaction
US5322785A (en) 1990-04-26 1994-06-21 New England Biolabs, Inc. Purified thermostable DNA polymerase obtainable from thermococcus litoralis
US5500363A (en) * 1990-04-26 1996-03-19 New England Biolabs, Inc. Recombinant thermostable DNA polymerase from archaebacteria
US5352778A (en) * 1990-04-26 1994-10-04 New England Biolabs, Inc. Recombinant thermostable DNA polymerase from archaebacteria
US5756334A (en) * 1990-04-26 1998-05-26 New England Biolabs, Inc. Thermostable DNA polymerase from 9°N-7 and methods for producing the same
US5407813A (en) * 1990-05-01 1995-04-18 Gold Biotechnology Preparation of nucleic acid deletion fragments
EP1507000B1 (en) 1990-05-03 2010-03-03 Cornell Research Foundation, Inc. A thermostable ligase mediated DNA amplification system for the detection of genetic diseases
US5387505A (en) * 1990-05-04 1995-02-07 Eastman Kodak Company Preparation and isolation of single-stranded biotinylated nucleic acids by heat avidin-biotin cleavage
US5494810A (en) * 1990-05-03 1996-02-27 Cornell Research Foundation, Inc. Thermostable ligase-mediated DNA amplifications system for the detection of genetic disease
CA2116215C (en) * 1990-05-07 1998-12-22 Tapestry Pharmaceuticals, Inc. Diagnostic applications of double d-loop formation
US5223414A (en) * 1990-05-07 1993-06-29 Sri International Process for nucleic acid hybridization and amplification
US5273881A (en) * 1990-05-07 1993-12-28 Daikin Industries, Ltd. Diagnostic applications of double D-loop formation
US7585512B1 (en) 1990-05-08 2009-09-08 Thomas Jefferson University Composition and method of using tumor cells
US5348857A (en) * 1990-05-22 1994-09-20 Texas A & M University Probes and method for identifying species and biovars of brucella
US5310649A (en) * 1990-05-22 1994-05-10 Texas A & M University System Method for detecting species and biovars of Brucella
US7273749B1 (en) 1990-06-04 2007-09-25 University Of Utah Research Foundation Container for carrying out and monitoring biological processes
US7294712B2 (en) * 1990-06-04 2007-11-13 Aventis Pharma S.A. Nucleotide sequences coding for variable regions of β chains of human T lymphocyte receptors, corresponding peptide segments and the diagnostic and therapeutic uses
US6787338B2 (en) * 1990-06-04 2004-09-07 The University Of Utah Method for rapid thermal cycling of biological samples
US5455175A (en) * 1990-06-04 1995-10-03 University Of Utah Research Foundation Rapid thermal cycling device
US5935522A (en) * 1990-06-04 1999-08-10 University Of Utah Research Foundation On-line DNA analysis system with rapid thermal cycling
US5296349A (en) * 1990-06-14 1994-03-22 Emory University Molecular genetic test for myoclonic epilepsy
US5844108A (en) * 1990-06-22 1998-12-01 Roche Molecular Systems, Inc. Primers targeted to NAT2 gene for detection of poor metabolizers of drugs
US5187084A (en) * 1990-06-22 1993-02-16 The Dow Chemical Company Automatic air temperature cycler and method of use in polymerose chain reaction
DE69126064T2 (de) * 1990-06-22 1997-08-28 Hoffmann La Roche Nachweis von schwachen Metabolisierungsreagentien von Drogen
US5545526A (en) * 1990-06-27 1996-08-13 Blood Center Research Foundation, Inc., The Method for HLA Typing
US5468611A (en) * 1990-06-27 1995-11-21 The Blood Center Research Foundation, Inc. Method for HLA typing
US6503707B1 (en) 1990-06-27 2003-01-07 The Blood Center Research Foundation, Inc. Method for genetic typing
FR2663949A1 (fr) 1990-06-29 1992-01-03 Genset Sa Perfectionnements a un procede d'amplification enzymatique in vitro.
DE4021458C1 (ko) * 1990-07-05 1991-08-29 Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften Ev, 3400 Goettingen, De
US5134063A (en) * 1990-07-06 1992-07-28 Biolog, Inc. Methods for detection, identification and specification of listerias
US5556747A (en) * 1990-07-09 1996-09-17 E. R. Squibb & Sons, Inc. Method for site-directed mutagenesis
US5851762A (en) * 1990-07-11 1998-12-22 Gene Type Ag Genomic mapping method by direct haplotyping using intron sequence analysis
DK0540693T3 (da) * 1990-07-24 1999-09-13 Hoffmann La Roche Reduktion af ikke-specifik amplifikation under in vitro-nukleinsyreamplifikation under anvendelse af modificerede nukleinsy
US5210015A (en) * 1990-08-06 1993-05-11 Hoffman-La Roche Inc. Homogeneous assay system using the nuclease activity of a nucleic acid polymerase
US6395966B1 (en) 1990-08-09 2002-05-28 Dekalb Genetics Corp. Fertile transgenic maize plants containing a gene encoding the pat protein
JP2560160B2 (ja) * 1990-08-20 1996-12-04 社団法人北里研究所 新規なｄｎａ塩基配列およびその用途
JPH06500471A (ja) * 1990-08-24 1994-01-20 ザ・ユニバーシティ・オブ・テネシー・リサーチ・コーポレーション Ｄｎａ増幅フィンガープリント法
US6074818A (en) * 1990-08-24 2000-06-13 The University Of Tennessee Research Corporation Fingerprinting of nucleic acids, products and methods
US5527670A (en) * 1990-09-12 1996-06-18 Scientific Generics Limited Electrochemical denaturation of double-stranded nucleic acid
US5824477A (en) * 1990-09-12 1998-10-20 Scientific Generics Limited Electrochemical denaturation of double-stranded nucleic acid
US6197508B1 (en) 1990-09-12 2001-03-06 Affymetrix, Inc. Electrochemical denaturation and annealing of nucleic acid
AU8740491A (en) * 1990-09-28 1992-04-28 Protein Engineering Corporation Proteinaceous anti-dental plaque agents
US5932414A (en) * 1990-09-28 1999-08-03 University Of Texas Systems Board Of Regents Methods and compositions for the monitoring and quantitation of minimal residual disease in hematopoietic tumors
US5168039A (en) * 1990-09-28 1992-12-01 The Board Of Trustees Of The University Of Arkansas Repetitive DNA sequence specific for mycobacterium tuberculosis to be used for the diagnosis of tuberculosis
US5635348A (en) * 1990-10-05 1997-06-03 Hoffmann-La Roche Inc. Method and probes for identifying bacteria found in blood
US5965364A (en) 1990-10-09 1999-10-12 Benner; Steven Albert Method for selecting functional deoxyribonucleotide derivatives
WO1992007095A1 (en) 1990-10-15 1992-04-30 Stratagene Arbitrarily primed polymerase chain reaction method for fingerprinting genomes
JPH04152899A (ja) * 1990-10-17 1992-05-26 Shionogi & Co Ltd ２段階ｐｃｒ法によるｈｉｖ―１ゲノムの検出法およびオリゴヌクレオチド
US5846710A (en) * 1990-11-02 1998-12-08 St. Louis University Method for the detection of genetic diseases and gene sequence variations by single nucleotide primer extension
US5474895A (en) * 1990-11-14 1995-12-12 Siska Diagnostics Inc. Non-isotopic detection of nucleic acids using a polystyrene support-based sandwich hybridization assay and compositions useful therefor
US5654179A (en) * 1990-11-14 1997-08-05 Hri Research, Inc. Nucleic acid preparation methods
US5284940A (en) * 1990-11-14 1994-02-08 Hri Research, Inc. Preparation for nucleic acid samples
US5620852A (en) * 1990-11-14 1997-04-15 Hri Research, Inc. Nucleic acid preparation methods
ES2109336T3 (es) 1990-11-26 1998-01-16 Genetics Inst Expresion de pace en celulas huesped y metodos de utilizacion de la misma.
KR100236506B1 (ko) * 1990-11-29 2000-01-15 퍼킨-엘머시터스인스트루먼츠 폴리머라제 연쇄 반응 수행 장치
EP0488243A1 (en) * 1990-11-30 1992-06-03 Sanwa Kagaku Kenkyusho Co., Ltd. Method of extracting virus genome from sample derived from living body infected with the virus and detecting the genome
DK0834576T3 (da) 1990-12-06 2002-04-22 Affymetrix Inc A Delaware Corp Påvisning af nukleinsyresekvenser
US5569601A (en) 1990-12-07 1996-10-29 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education On Behalf Of The Oregon Health Sciences University Human dopamine receptor and its uses
JP3298879B2 (ja) * 1990-12-20 2002-07-08 イグジス，インコーポレイテッド 結合タンパク質の最適化
US5162209A (en) * 1991-01-18 1992-11-10 Beth Israel Hospital Association Synthesis of full-length, double-stranded dna from a single-stranded linear dna template
US5714326A (en) * 1991-01-24 1998-02-03 Dawson; Elliott P. Method for the multiplexed preparation of nucleic acid molecular weight markers and resultant products
US5455166A (en) * 1991-01-31 1995-10-03 Becton, Dickinson And Company Strand displacement amplification
EP0528007A1 (fr) * 1991-02-12 1993-02-24 Roussel Uclaf SEQUENCES NUCLEOTIDIQUES CODANT POUR DES REGIONS VARIABLES DE CHAINES $g(b) DES RECEPTEURS DES LYMPHOCYTES T HUMAINS, SEGMENTS PEPTIDIQUES CORRESPONDANTS ET LES APPLICATIONS DIAGNOSTIQUES ET THERAPEUTIQUES
US5491068A (en) * 1991-02-14 1996-02-13 Vicam, L.P. Assay method for detecting the presence of bacteria
US5461032A (en) * 1991-03-01 1995-10-24 Fmc Corporation Insecticidally effective peptides
DK1279731T3 (da) 1991-03-01 2007-09-24 Dyax Corp Fremgangsmåde til udvikling af bindende miniproteiner
US5888819A (en) * 1991-03-05 1999-03-30 Molecular Tool, Inc. Method for determining nucleotide identity through primer extension
US5578443A (en) * 1991-03-06 1996-11-26 Regents Of The University Of Minnesota DNA sequence-based HLA typing method
WO1992015711A1 (en) * 1991-03-06 1992-09-17 Regents Of The University Of Minnesota Dna sequence-based hla typing method
US5856457A (en) * 1991-03-29 1999-01-05 Genentech, Inc. Nucleic acids encoding a human IL-8 receptor
US5436144A (en) * 1991-04-08 1995-07-25 Health Research, Inc. Process for performing PCR in mammalian cells
WO1992018521A1 (en) * 1991-04-10 1992-10-29 Life Technologies, Inc. Method for amplifying and altering an rna sequence
CA2084405A1 (en) * 1991-04-11 1992-10-12 Chao-Huei Jeffrey Wang Detection of dna/rna by fluorescence polarization
AU1970892A (en) * 1991-04-18 1992-11-17 United States Of America, Represented By The Secretary, Department Of Health And Human Services, The Identification of a new ehrlichia species from a patient suffering from ehrlichiosis
CA2065719A1 (en) 1991-04-30 1992-10-31 John B. Findlay Nucleic acid amplification and detection methods using rapid polymerase chain reaction cycle
US5525462A (en) * 1991-05-02 1996-06-11 Toyo Boseki Kabushiki Kaisha Nucleic acid sequence amplification method, detection method, and reagent kit therefor
US5994056A (en) 1991-05-02 1999-11-30 Roche Molecular Systems, Inc. Homogeneous methods for nucleic acid amplification and detection
US5424184A (en) * 1991-05-08 1995-06-13 Regents Of The University Of Minnesota DNA sequence-based HLA class I typing method
US5571690A (en) * 1991-05-08 1996-11-05 The University Of Virginia Patents Foundation Method for the cell-free synthesis of proteins
US6190864B1 (en) * 1991-05-08 2001-02-20 Chiron Corporation HCV genomic sequences for diagnostics and therapeutics
EP0584238A1 (en) * 1991-05-17 1994-03-02 Chiron Corporation INHIBITOR OF NF-$g(k)B TRANSCRIPTIONAL ACTIVATOR AND USES THEREOF
US5703221A (en) * 1991-05-23 1997-12-30 Martin; William John Stealth virus nucleic acids and related methods
US5756281A (en) * 1991-05-23 1998-05-26 Martin; William John Stealth virus detection in the chronic fatigue syndrome
US5753488A (en) * 1991-05-23 1998-05-19 Martin; William John Isolated stealth viruses and related vaccines
US5861504A (en) * 1991-05-29 1999-01-19 The United States Of America As Represented By The Department Of Health And Human Services Eleven highly informative microsatelite repeat polymorphic DNA markers
US5468610A (en) * 1991-05-29 1995-11-21 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Three highly informative microsatellite repeat polymorphic DNA markers
US5378602A (en) * 1991-05-29 1995-01-03 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Highly informative microsatellite repeat polymorphic DNA markers twenty-[seven]six
US5658728A (en) * 1991-06-19 1997-08-19 Gosney, Jr.; William Milton Templates for nucleic acid molecules
ES2091976T3 (es) * 1991-06-20 1996-11-16 Hoffmann La Roche Metodos perfeccionados para la amplificacion del acido nucleico.
US5851795A (en) * 1991-06-27 1998-12-22 Bristol-Myers Squibb Company Soluble CTLA4 molecules and uses thereof
US6887471B1 (en) 1991-06-27 2005-05-03 Bristol-Myers Squibb Company Method to inhibit T cell interactions with soluble B7
US6090914A (en) * 1991-06-27 2000-07-18 Bristol-Myers Squibb Company CTLA4/CD28Ig hybrid fusion proteins and uses thereof
US5770197A (en) * 1991-06-27 1998-06-23 Bristol-Myers Squibb Company Methods for regulating the immune response using B7 binding molecules and IL4-binding molecules
WO1993000431A1 (en) * 1991-06-27 1993-01-07 Bristol-Myers Squibb Company Ctl4a receptor, fusion proteins containing it and uses thereof
US5569582A (en) * 1991-07-15 1996-10-29 Institute Of Molecular Biology & Technology Rapid amplification and detection of nucleic acids
US5260199A (en) * 1991-07-30 1993-11-09 Wisconsin Alumni Research Foundation Method of producing 1,25-dihydroxyvitamin D3 receptor protein
US5437976A (en) * 1991-08-08 1995-08-01 Arizona Board Of Regents, The University Of Arizona Multi-domain DNA ligands bound to a solid matrix for protein and nucleic acid affinity chromatography and processing of solid-phase DNA
US5478724A (en) * 1991-08-16 1995-12-26 The Rockefeller University Lentivirus-specific nucleotide probes and methods of use
US5506098A (en) * 1991-09-04 1996-04-09 Daikin Industries, Ltd. In situ hybridization method
DE4129653A1 (de) * 1991-09-06 1993-03-11 Boehringer Mannheim Gmbh Verfahren zum nachweis aehnlicher nukleinsaeuren
US6872816B1 (en) * 1996-01-24 2005-03-29 Third Wave Technologies, Inc. Nucleic acid detection kits
US5846717A (en) * 1996-01-24 1998-12-08 Third Wave Technologies, Inc. Detection of nucleic acid sequences by invader-directed cleavage
US5994069A (en) 1996-01-24 1999-11-30 Third Wave Technologies, Inc. Detection of nucleic acids by multiple sequential invasive cleavages
EP0648281A4 (en) * 1991-09-10 1997-06-04 Jack D Love TARGETED AMPLIFICATION OF DNA AND RNA AND SIGNAL AMPLIFICATION.
EP0534640B1 (en) * 1991-09-23 1996-10-02 Pfizer Inc. Process for detecting specific mRNA and DNA in cells
WO1993007161A1 (en) * 1991-10-04 1993-04-15 Cornell Research Foundation, Inc. Molecular cloning and transformation of cyclodiene resistance
DE69223755T2 (de) 1991-10-11 1998-04-23 Behringwerke Ag Verfahren zur Herstellung eines Polynukleotids zum Gebrauch in "single-primer" Amplifizierung und Phosphorothioat-enthaltende Oligonukleotide als Primer in Nukleinsäureamplifizierung
US5612199A (en) * 1991-10-11 1997-03-18 Behringwerke Ag Method for producing a polynucleotide for use in single primer amplification
US5411875A (en) * 1991-11-01 1995-05-02 University Of Iowa Research Foundation Method for retrieval of unknown flanking DNA sequence
US5350835A (en) * 1991-11-05 1994-09-27 Board Of Regents, University Of Texas Cellular nucleic acid binding protein and uses thereof in regulating gene expression and in the treatment of aids
US6265157B1 (en) 1991-12-03 2001-07-24 Allegheny University Of The Health Sciences Compositions and methods for detecting altered COL1A1 gene sequences
US5939524A (en) * 1991-12-09 1999-08-17 The Scripps Research Institute Platelet GPIII P1A1 and P1A2 epitopes, their preparation and use
US6033854A (en) * 1991-12-16 2000-03-07 Biotronics Corporation Quantitative PCR using blocking oligonucleotides
US5567583A (en) * 1991-12-16 1996-10-22 Biotronics Corporation Methods for reducing non-specific priming in DNA detection
US5348853A (en) * 1991-12-16 1994-09-20 Biotronics Corporation Method for reducing non-specific priming in DNA amplification
US5256555A (en) 1991-12-20 1993-10-26 Ambion, Inc. Compositions and methods for increasing the yields of in vitro RNA transcription and other polynucleotide synthetic reactions
AU3428493A (en) * 1991-12-31 1993-07-28 Zymogenetics Inc. Novel human transglutaminases
USH1985H1 (en) 1992-01-09 2001-08-07 The United States Of America As Represented By The Secretary Of The Navy Method for detecting biological toxins
US5656467A (en) * 1992-01-09 1997-08-12 The Trustees Of The University Of Pennsylvania Methods and materials for producing gene libraries
WO1993014217A1 (en) * 1992-01-10 1993-07-22 Life Technologies, Inc. Use of predetermined nucleotides having altered base pairing characteristics in the amplification of nucleic acid molecules
GB9201481D0 (en) * 1992-01-23 1992-03-11 Scient Generics Ltd Treatment of nucleic acid material
IL104419A0 (en) * 1992-01-24 1993-05-13 Fmc Corp Insecticidally effective peptides
US5372929A (en) * 1992-01-27 1994-12-13 Cimino; George D. Methods for measuring the inactivation of pathogens
US6200747B1 (en) 1992-01-28 2001-03-13 North Shore University Hospital Research Corp. Method and kits for detection of fragile X specific, GC-rich DNA sequences
US5859219A (en) * 1992-02-26 1999-01-12 Vanderbilt University Purified vacuolating toxin from Helicobacter pylori and methods to use same
US5856097A (en) * 1992-03-04 1999-01-05 The Regents Of The University Of California Comparative genomic hybridization (CGH)
US7534567B2 (en) * 1992-03-04 2009-05-19 The Regents Of The University Of California Detection of nucleic acid sequence differences by comparative genomic hybridization
ATE205542T1 (de) * 1992-03-04 2001-09-15 Univ California Vergleichende genomhybridisierung
US5420009A (en) * 1992-03-23 1995-05-30 The United States Of America As Represented By The Secretary Of Agriculture Detection of Xanthomonas campestris pv. citri by hybridization and polymerase chain reaction assays
JPH05260980A (ja) * 1992-03-23 1993-10-12 Tokyo Met Gov Shinkei Kagaku Sogo Kenkyusho ヒト・アリルアミンｎ−アセチル転移酵素遺伝子
DE69207580T2 (de) * 1992-03-23 1996-08-08 Hoffmann La Roche Verfahren zum DNS-Nachweis
WO1993020234A1 (en) * 1992-03-31 1993-10-14 E.I. Du Pont De Nemours And Company A rapid, high capacity nucleic acid based assay
ATE173767T1 (de) * 1992-04-03 1998-12-15 Perkin Elmer Corp Proben zusammensetzung und verfahren
US5470705A (en) * 1992-04-03 1995-11-28 Applied Biosystems, Inc. Probe composition containing a binding domain and polymer chain and methods of use
US5532347A (en) * 1992-04-10 1996-07-02 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education On Behalf Of The Oregon Health Sciences University, A Non-Profit Organization DNA encoding α melanocyte stimulating hormone receptor
US5280112A (en) * 1992-04-10 1994-01-18 State Of Oregon, Oregon Health Sciences University DNA sequence encoding bovine and human adrenocorticotropic hormone receptors
US6100048A (en) * 1992-04-10 2000-08-08 Oregon Health Sciences University Methods and reagents for discovering and using mammalian melanocortin receptor agonists and antagonists to modulate feeding behavior in animals
US6110742A (en) * 1992-04-15 2000-08-29 Yissum Research Development Company Of The Hebrew University Of Jerusalem Synthetic antisense oligodeoxynucleotides targeted to AChE
USRE39031E1 (en) * 1992-04-29 2006-03-21 Biomerieux RNA amplification method requiring only one manipulation step
FR2690691B1 (fr) * 1992-04-29 1999-02-12 Bio Merieux Procede d'amplification d'arn necessitant une seule etape de manipulation.
US5792632A (en) 1992-05-05 1998-08-11 Institut Pasteur Nucleotide sequence encoding the enzyme I-SceI and the uses thereof
KR100249110B1 (ko) * 1992-05-06 2000-04-01 다니엘 엘. 캐시앙 핵산 서열 증폭 방법, 이에 이용되는 조성물 및 키트
US6063764A (en) * 1992-06-01 2000-05-16 Washington University & Chiron Corp. Method for using lipoprotein associated coagulation inhibitor to treat sepsis
US20030171292A1 (en) * 1992-06-01 2003-09-11 Creasey Abla A. Method for using lipoprotein associated coagulation inhibitor to treat sepsis
CA2137563C (en) * 1992-06-08 2005-06-28 Thomas B. Ryder Preparation of nucleic acid from mononuclear cells
ES2044784B1 (es) * 1992-06-12 1994-09-01 Inia Procedimiento para la deteccion e identificacion de patogenos virales y subvirales.
US5843640A (en) * 1992-06-19 1998-12-01 Northwestern University Method of simultaneously detecting amplified nucleic acid sequences and cellular antigens in cells
WO1994000598A1 (en) * 1992-06-19 1994-01-06 Northwestern University Method of detecting amplified nucleic acid sequences in cells by flow cytometry
US5612200A (en) * 1992-06-24 1997-03-18 Gen-Probe Incorporated Method and kit for destroying ability of nucleic acid to be amplified
US5397703A (en) * 1992-07-09 1995-03-14 Cetus Oncology Corporation Method for generation of antibodies to cell surface molecules
US5747034A (en) * 1992-07-09 1998-05-05 Chiron Corporation Methods and materials for the induction of T cell anergy
WO1994001585A1 (en) * 1992-07-14 1994-01-20 Worcester Polytechnic Institute Method of selecting genetically superior shrimp
WO1994003637A1 (en) * 1992-07-31 1994-02-17 Syntex (Usa) Inc. Method for introducing defined sequences at the 3' end of polynucleotides
CA2141300C (en) * 1992-07-31 2006-03-14 Nigel Alexander Morrison Assessment of vitamin d receptors allelic variation
US6207368B1 (en) 1992-08-04 2001-03-27 Beckman Coulter, Inc. Methods and reagents for controlling chain extension and ligation chain reactions
US6261808B1 (en) 1992-08-04 2001-07-17 Replicon, Inc. Amplification of nucleic acid molecules via circular replicons
US5834202A (en) * 1992-08-04 1998-11-10 Replicon, Inc. Methods for the isothermal amplification of nucleic acid molecules
US5733733A (en) * 1992-08-04 1998-03-31 Replicon, Inc. Methods for the isothermal amplification of nucleic acid molecules
WO1994003624A1 (en) * 1992-08-04 1994-02-17 Auerbach Jeffrey I Methods for the isothermal amplification of nucleic acid molecules
US6180338B1 (en) 1992-08-04 2001-01-30 Beckman Coulter, Inc. Method, reagent and kit for the detection and amplification of nucleic acid sequences
US5464945A (en) * 1992-08-28 1995-11-07 Hoffmann-La Roche Inc. Oligonucleotide probes specific for the human alpha satellite locus
US6264915B1 (en) 1992-09-13 2001-07-24 The President And Fellows Of Harvard College Process for detecting potential carcinogens
US5389515A (en) * 1992-09-15 1995-02-14 Boehringer Mannheim Corporation Isolated nucleotide sequences for identifying Neisseria gonorrhoeae
JP3292387B2 (ja) * 1992-09-29 2002-06-17 株式会社エスアールエル 新規ｄｎａ、それがコ−ドするポリペプチド及びそれらの検出方法
WO1994009138A1 (en) * 1992-10-20 1994-04-28 Cetus Oncology Corporation Interleukin-6 receptor antagonists
GB9223035D0 (en) * 1992-11-03 1992-12-16 Kiessling Cooper Ann A Preservation of peripheral blood & semen in fixatives that inactivate human pathogens
WO1994012881A2 (en) * 1992-12-02 1994-06-09 Hochstrasser Denis F A METHOD FOR DETECTING GROWING CELLS USING TRANSLATIONALLY CONTROLLED TUMOR PROTEIN p21
US5888780A (en) * 1992-12-07 1999-03-30 Third Wave Technologies, Inc. Rapid detection and identification of nucleic acid variants
US6372424B1 (en) * 1995-08-30 2002-04-16 Third Wave Technologies, Inc Rapid detection and identification of pathogens
WO1994013837A1 (en) * 1992-12-07 1994-06-23 Lionel Resnick Method for detecting a virus
US5541311A (en) * 1992-12-07 1996-07-30 Third Wave Technologies, Inc. Nucleic acid encoding synthesis-deficient thermostable DNA polymerase
US5719028A (en) * 1992-12-07 1998-02-17 Third Wave Technologies Inc. Cleavase fragment length polymorphism
US5843654A (en) * 1992-12-07 1998-12-01 Third Wave Technologies, Inc. Rapid detection of mutations in the p53 gene
US7691573B2 (en) * 1992-12-07 2010-04-06 Third Wave Technologies, Inc. Cleavage of nucleic acids
US5614402A (en) * 1992-12-07 1997-03-25 Third Wave Technologies, Inc. 5' nucleases derived from thermostable DNA polymerase
US6673616B1 (en) * 1992-12-07 2004-01-06 Third Wave Technologies, Inc. Methods and compositions for characterizing nucleic acids
US5340728A (en) * 1992-12-09 1994-08-23 E. I. Du Pont De Nemours And Company Method for amplification of targeted segments of nucleic acid using nested polymerase chain reaction
US20060084092A1 (en) * 1993-01-05 2006-04-20 Gelfand David H Homogeneous assay system
US5605798A (en) * 1993-01-07 1997-02-25 Sequenom, Inc. DNA diagnostic based on mass spectrometry
AU6031094A (en) * 1993-01-15 1994-08-15 Public Health Research Institute Of The City Of New York, Inc., The Sensitive nucleic acid sandwich hybridization assays and kits
US5773253A (en) * 1993-01-22 1998-06-30 Bristol-Myers Squibb Company MYPPPY variants of CTL A4 and uses thereof
DE4301693A1 (de) * 1993-01-22 1994-07-28 Cytech Biomedical Inc Verfahren zur Amplifikation und Verfahren zum Nachweis von Polynucleotidsequenzen an fester Phase
US5593840A (en) * 1993-01-27 1997-01-14 Oncor, Inc. Amplification of nucleic acid sequences
DE4302459A1 (de) * 1993-01-29 1994-08-04 Bayer Ag Sulfocumarinhaltige Nukleotide und deren Verwendung in Nachweisverfahren für Nukleinsäuren
IL108497A0 (en) * 1993-02-01 1994-05-30 Seq Ltd Methods and apparatus for dna sequencing
US5364790A (en) * 1993-02-16 1994-11-15 The Perkin-Elmer Corporation In situ PCR amplification system
WO1994019491A1 (en) * 1993-02-17 1994-09-01 Genetic Therapy, Inc. Detection of replication competent viruses
US6410277B1 (en) 1993-02-19 2002-06-25 Takara Shuzo Co., Ltd. DNA polymersases with enhanced length of primer extension
US5436149A (en) * 1993-02-19 1995-07-25 Barnes; Wayne M. Thermostable DNA polymerase with enhanced thermostability and enhanced length and efficiency of primer extension
US7465539B1 (en) 1993-02-19 2008-12-16 Takara Bio, Inc. DNA polymerases with enhanced length of primer extension
US5583210A (en) * 1993-03-18 1996-12-10 Pioneer Hi-Bred International, Inc. Methods and compositions for controlling plant development
US5395752A (en) * 1993-03-19 1995-03-07 Ciba Corning Diagnostics Corp. Long emission wavelength chemiluminescent compounds and their use in test assays
US5643765A (en) * 1993-04-06 1997-07-01 University Of Rochester Method for quantitative measurement of gene expression using multiplex competitive reverse transcriptase-polymerase chain reaction
US5639606A (en) * 1993-04-06 1997-06-17 The University Of Rochester Method for quantitative measurement of gene expression using multiplex competitive reverse transcriptase-polymerase chain reaction
US5736334A (en) * 1993-04-12 1998-04-07 Abbott Laboratories Nucleotide sequences and process for amplifying and detection of hepatitis B viral DNA
US6294323B1 (en) 1993-04-14 2001-09-25 Behringwerke Ag Self initiating single primer amplification of nucleic acids
US5462854A (en) * 1993-04-19 1995-10-31 Beckman Instruments, Inc. Inverse linkage oligonucleotides for chemical and enzymatic processes
US5470723A (en) * 1993-05-05 1995-11-28 Becton, Dickinson And Company Detection of mycobacteria by multiplex nucleic acid amplification
DE69433160T2 (de) 1993-05-12 2004-07-08 Chiron Corp. (N.D.Ges.D. Staates Delaware), Emeryville Konserviertes Motiv der Hepatitis C Virus E2/NS1 Region
US6709813B1 (en) 1993-05-14 2004-03-23 Ortho-Clinical Diagnostics, Inc. Diagnostic compositions, elements, methods and test kits for amplification and detection of human CMV DNA using primers having matched melting temperatures
US6174668B1 (en) * 1993-05-14 2001-01-16 Johnson & Johnson Clinical Diagnostics, Inc. Diagnostic compositions, elements, methods and test kits for amplification and detection of two or more target DNA's using primers having matched melting temperatures
US5491086A (en) * 1993-05-14 1996-02-13 Hoffmann-La Roche Inc. Purified thermostable nucleic acid polymerase and DNA coding sequences from pyrodictium species
US5403707A (en) * 1993-05-14 1995-04-04 Eastman Kodak Company Diagnostic compositions, elements, methods and test kits for amplification and detection of retroviral DNA using primers having matched melting temperatures
US6774227B1 (en) * 1993-05-17 2004-08-10 Cytokine Pharmasciences, Inc. Therapeutic uses of factors which inhibit or neutralize MIF activity
US6080407A (en) 1993-05-17 2000-06-27 The Picower Institute For Medical Research Diagnostic assays for MIF
JPH08510649A (ja) * 1993-05-28 1996-11-12 マウント シナイ スクール オブ メディシン オブ ザ シティー ユニバーシティー オブ ニューヨーク Ｂｃ２００ｒｎａ、それに対するプローブ及びその使用
DE4344742A1 (de) * 1993-06-09 1994-12-15 Boehringer Mannheim Gmbh Verfahren zur Immobilisierung von Nukleinsäuren
US5550040A (en) 1993-06-23 1996-08-27 Hoffman-La Roche Inc. Method, reagents and kits for the detection of Neisseria gonorrhoeae
US5593823A (en) * 1993-06-28 1997-01-14 Cerus Corporation Method for inactivating pathogens in blood using photoactivation of 4'-primary amino-substituted psoralens
US6004742A (en) * 1993-06-28 1999-12-21 Cerus Corporation Method for inactivation of pathogens in platelets using 4' and 5' primary amino-substituted psoralens
US6420570B1 (en) 1993-06-28 2002-07-16 Cerus Corporation Psoralen compounds
US5556993A (en) * 1993-06-28 1996-09-17 Steritech, Inc. Compounds for the photodecontamination of pathogens in blood
US5871900A (en) * 1993-06-28 1999-02-16 Cerus Corporation Method of inactivating pathogens in biological fluids using photoactivated 5-primaryamino psoralens
US5399719A (en) * 1993-06-28 1995-03-21 Steritech, Inc. Compounds for the photodecontamination of pathogens in blood
US6406841B1 (en) 1993-07-01 2002-06-18 Abbott Laboratories Methods for the detection of HTLV-II antibodies employing novel HTLV-II NRA envelope peptides
US5457178A (en) * 1993-07-07 1995-10-10 Fmc Corporation Insecticidally effective spider toxin
US5512430A (en) * 1993-07-13 1996-04-30 Hri Research, Inc. Diagnostic array for virus infection
WO1995003430A1 (en) * 1993-07-23 1995-02-02 Gen-Probe Incorporated Methods for enhancing nucleic acid amplification
DE69429038T2 (de) * 1993-07-28 2002-03-21 Pe Corp Ny Norwalk Vorrichtung und Verfahren zur Nukleinsäurevervielfältigung
CA2168245A1 (en) 1993-07-29 1995-02-09 C. Anthony Hunt Polynucleotide decoys that inhibit mhc-ii expression and uses thereof
AU7551594A (en) * 1993-07-29 1995-02-28 MURASHIGE, Kate H. Method for recognition of the nucleotide sequence of a purified dna segment
US6118047A (en) 1993-08-25 2000-09-12 Dekalb Genetic Corporation Anthranilate synthase gene and method of use thereof for conferring tryptophan overproduction
US5780709A (en) * 1993-08-25 1998-07-14 Dekalb Genetics Corporation Transgenic maize with increased mannitol content
US6326527B1 (en) 1993-08-25 2001-12-04 Dekalb Genetics Corporation Method for altering the nutritional content of plant seed
US6281411B1 (en) 1993-08-25 2001-08-28 Dekalb Genetics Corporation Transgenic monocots plants with increased glycine-betaine content
US6376178B1 (en) 1993-09-03 2002-04-23 Duke University Method of nucleic acid sequencing
AU7679394A (en) * 1993-09-03 1995-03-22 Duke University A method of nucleic acid sequencing
US5426039A (en) * 1993-09-08 1995-06-20 Bio-Rad Laboratories, Inc. Direct molecular cloning of primer extended DNA containing an alkane diol
ATE215989T1 (de) 1993-09-15 2002-04-15 Chiron Corp Rekombinanter alphavirus vektor
US5597694A (en) * 1993-10-07 1997-01-28 Massachusetts Institute Of Technology Interspersed repetitive element-bubble amplification of nucleic acids
US5658782A (en) * 1993-10-20 1997-08-19 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education On Behalf Of The Oregon Health Sciences University A Non-Profit Organization Amino acid transporters and uses
US5912171A (en) 1993-10-20 1999-06-15 Oregon Health Science University Amino acid transporters and uses
US5882926A (en) 1993-10-20 1999-03-16 Oregon Health Sciences University Excitatory amino acid transporter gene and uses
US5601990A (en) * 1994-09-13 1997-02-11 Thomas Jefferson University Methods of diagnosing colorectal tumors and metastasis thereof
US7097839B1 (en) 1993-10-26 2006-08-29 Thomas Jefferson University ST receptor binding compounds and methods of using the same
CA2174928C (en) * 1993-10-26 2011-08-16 Scott A. Waldman Compositions that specifically bind to colorectal cancer cells and methods of using the same
US5879656A (en) * 1993-10-26 1999-03-09 Thomas Jefferson University Methods of treating metastatic colorectal cancer with ST receptor binding compounds
US7375198B2 (en) 1993-10-26 2008-05-20 Affymetrix, Inc. Modified nucleic acid probes
US6680378B1 (en) * 1993-10-28 2004-01-20 Invitrogen Corporation Nucleic acid marker ladder for estimating mass
FR2711672B1 (fr) * 1993-10-29 1995-12-08 France Etat Armement Procédé de sélection et/ou d'obtention de sondes capables de détecter de nouvelles régions à nombre variable de répétitions en tandem, sondes pouvant être ainsi obtenues et leurs utilisations.
DE4337295A1 (de) * 1993-11-02 1995-05-04 Merck Patent Gmbh Oligonukleotide für den Nachweis von Enterobacteriaceae
ES2240970T3 (es) * 1993-11-03 2005-10-16 Orchid Biosciences, Inc. Polimorfismos de nucleotido simple y su uso en analisis geneticos.
US5658783A (en) * 1993-11-08 1997-08-19 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education On Behalf Of The Oregon Health Sciences University, A Non-Profit Organization Mammalian methadone-specific opioid receptor gene and uses
US6235470B1 (en) 1993-11-12 2001-05-22 The Johns Hopkins University School Of Medicine Detection of neoplasia by analysis of saliva
US5589329A (en) * 1993-11-15 1996-12-31 Ambion, Inc. Methods and compositions for detecting base pair mismatches
WO1995014106A2 (en) * 1993-11-17 1995-05-26 Id Biomedical Corporation Cycling probe cleavage detection of nucleic acid sequences
CA2176805A1 (en) * 1993-11-23 1995-06-01 Douglas N. Ludtke Use of antisense oligomers in a process for controlling contamination in nucleic acid amplification reactions
US5474920A (en) * 1993-11-23 1995-12-12 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education On Behalf Of The Oregon Health Sciences University Modified thermo-resistant DNA polymerases
US5556772A (en) * 1993-12-08 1996-09-17 Stratagene Polymerase compositions and uses thereof
US7312052B1 (en) * 1993-12-08 2007-12-25 Stratagene California Polymerase compositions and uses thereof
US5523204A (en) * 1993-12-10 1996-06-04 Becton Dickinson And Company Detection of nucleic acids in cells by strand displacement amplification
US6071699A (en) 1996-06-07 2000-06-06 California Institute Of Technology Nucleic acid mediated electron transfer
ES2078174B1 (es) * 1993-12-16 1996-08-16 Univ Cantabria Metodo de diagnostico molecular para la deteccion de brucella abortus y en diferenciacion de la cepa vacunal b19.
WO1995018236A1 (fr) * 1993-12-28 1995-07-06 Daikin Industries, Ltd. PROCEDE D'HYBRIDATION IN SITU AU MOYEN D'UNE PROTEINE RecA, ET PROTEINE RecA COMPRENANT UN MARQUEUR OU UN LIGAND UTILISEE POUR METTRE EN ×UVRE LEDIT PROCEDE
US6057299A (en) * 1994-01-13 2000-05-02 Calydon, Inc. Tissue-specific enhancer active in prostate
US5830686A (en) * 1994-01-13 1998-11-03 Calydon Tissue-specific enhancer active in prostate
US5840573A (en) * 1994-02-01 1998-11-24 Fields; Robert E. Molecular analyzer and method of use
DE69531542T2 (de) * 1994-02-07 2004-06-24 Beckman Coulter, Inc., Fullerton Ligase/polymerase-vermittelte analyse genetischer elemente von einzelnukleotid-polymorphismen und ihre verwendung in der genetischen analyse
US5543026A (en) * 1994-02-07 1996-08-06 The Perkin-Elmer Corporation Real-time scanning fluorescence electrophoresis apparatus for the analysis of polynucleotide fragments
FR2716263B1 (fr) * 1994-02-11 1997-01-17 Pasteur Institut Procédé d'alignement de macromolécules par passage d'un ménisque et applications dans un procédé de mise en évidence, séparation et/ou dosage d'une macromolécule dans un échantillon.
US5605793A (en) 1994-02-17 1997-02-25 Affymax Technologies N.V. Methods for in vitro recombination
US6995017B1 (en) 1994-02-17 2006-02-07 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
US6395547B1 (en) 1994-02-17 2002-05-28 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
US20060257890A1 (en) 1996-05-20 2006-11-16 Maxygen, Inc. Methods and compositions for cellular and metabolic engineering
US6117679A (en) 1994-02-17 2000-09-12 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
US5834252A (en) * 1995-04-18 1998-11-10 Glaxo Group Limited End-complementary polymerase reaction
US5837458A (en) 1994-02-17 1998-11-17 Maxygen, Inc. Methods and compositions for cellular and metabolic engineering
US6309883B1 (en) 1994-02-17 2001-10-30 Maxygen, Inc. Methods and compositions for cellular and metabolic engineering
US6165793A (en) * 1996-03-25 2000-12-26 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
US5928905A (en) * 1995-04-18 1999-07-27 Glaxo Group Limited End-complementary polymerase reaction
US6335160B1 (en) 1995-02-17 2002-01-01 Maxygen, Inc. Methods and compositions for polypeptide engineering
US5491069A (en) * 1994-02-18 1996-02-13 The Regents Of The University Of California Biomarkers of cell senescence
DE4405810A1 (de) 1994-02-23 1995-08-24 Behringwerke Ag Von einem Retrovirus aus der HIV-Gruppe abgeleitete Peptide und deren Verwendung
US5639940A (en) 1994-03-03 1997-06-17 Pharmaceutical Proteins Ltd. Production of fibrinogen in transgenic animals
EP0749494A1 (en) 1994-03-07 1996-12-27 Chiron Corporation Compositions for the inhibition of tnf formation and uses thereof
US5648271A (en) * 1994-03-11 1997-07-15 Barrskogen, Inc. Method for evaporating solvent using filter
ATE175723T1 (de) 1994-03-15 1999-01-15 Scient Generics Ltd Elektrochemische denatusierung von doppelsträngiger nukleinsäure
KR100230718B1 (ko) * 1994-03-16 1999-11-15 다니엘 엘. 캐시앙, 헨리 엘. 노르호프 등온 가닥 변위 핵산 증폭법
AU2187295A (en) * 1994-03-18 1995-10-09 General Hospital Corporation, The Cleaved amplified rflp detection methods
US6110709A (en) * 1994-03-18 2000-08-29 The General Hospital Corporation Cleaved amplified modified polymorphic sequence detection methods
US5698517A (en) * 1994-03-21 1997-12-16 University Of Hawaii, Office Of Technology Transfer And Economic Development Thyroxin-binding HSA fragments
MX196038B (es) 1994-03-29 2000-04-14 Novo Nordisk As Amilasa de bacillus alcalino.
US7252989B1 (en) 1994-04-04 2007-08-07 Board Of Regents, The University Of Texas System Adenovirus supervector system
US5714330A (en) * 1994-04-04 1998-02-03 Lynx Therapeutics, Inc. DNA sequencing by stepwise ligation and cleavage
US5831065A (en) * 1994-04-04 1998-11-03 Lynx Therapeutics, Inc. Kits for DNA sequencing by stepwise ligation and cleavage
US5552278A (en) * 1994-04-04 1996-09-03 Spectragen, Inc. DNA sequencing by stepwise ligation and cleavage
US5863724A (en) * 1994-04-13 1999-01-26 Baylor College Of Medicine Methods of screening for persistent hyperinsulinemic hypoglycemia of infancy
US5629167A (en) 1994-04-19 1997-05-13 Biocine S.P.A. Detection of antibodies against Chlamydia trachomatis pgp3 antigen in patient sera by enzyme-linked immunosorbent assay
US5705332A (en) * 1994-04-25 1998-01-06 University Of Hawaii Detection and identification of Salmonella and Shigella
JPH09512428A (ja) * 1994-04-25 1997-12-16 アビテック ディアゴノスティックス インク リゾルベース開裂による突然変異の検出
US5585238A (en) * 1994-04-25 1996-12-17 Ciba-Geigy Corporation Detection of fungal pathogens using the polymerase chain reaction
ES2078185B1 (es) * 1994-05-06 1996-08-16 Inia Procedimiento para la tipificacion molecular de patogenos virales con genoma rna y de patogenos subvirales mediante sintesis aleatoria de cdna.
JP4303315B2 (ja) 1994-05-09 2009-07-29 オックスフォード バイオメディカ（ユーケー）リミテッド 非交差性レトロウイルスベクター
US6013517A (en) * 1994-05-09 2000-01-11 Chiron Corporation Crossless retroviral vectors
WO1995031574A1 (en) * 1994-05-16 1995-11-23 Brigham And Women's Hospital Processes, apparatus and compositions for characterizing nucleotide sequences
WO1995033075A1 (en) * 1994-05-31 1995-12-07 Cornell Research Foundation, Inc. A method for the identification of nucleic acid samples from dna-containing organisms
US5698394A (en) * 1994-06-01 1997-12-16 Board Of Regents Of The University Of Nebraska Nucleotide sequences and methods for detection of Serpulina hyodysenteriae
US5658729A (en) 1994-10-11 1997-08-19 The University Of British Columbia Method, reagent and kit for evaluating susceptibility to premature atherosclerosis
US5766889A (en) 1994-06-08 1998-06-16 The Perkin-Elmer Corporation Method for determining the characteristics of the concentration growth of target nucleic acid molecules in polymerase chain reaction sample
US5814442A (en) * 1994-06-10 1998-09-29 Georgetown University Internally controlled virion nucleic acid amplification reaction for quantitation of virion and virion nucleic acid
AU2635295A (en) * 1994-06-13 1996-01-05 Henry Ford Health System A novel neuronal-neonatal gene: neuronatin
US5807522A (en) * 1994-06-17 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods for fabricating microarrays of biological samples
CA2150986C (en) 1994-06-17 1999-11-02 Mary Kathryn Meyer Oligonucleotide primers and probes for detection of bacteria
US7323298B1 (en) 1994-06-17 2008-01-29 The Board Of Trustees Of The Leland Stanford Junior University Microarray for determining the relative abundances of polynuceotide sequences
DE4421901A1 (de) 1994-06-23 1996-01-04 Bayer Ag Ein DNA-Schnelltest zum Nachweis von chinolonresistenten Staphylococcus aureus Erregern in klinischem Probenmaterial
US6306657B1 (en) * 1994-06-28 2001-10-23 Kalyx Biosciences, Inc. Polynucleotide probe and kit for amplifying signal detection in hybridization assays
US6576236B1 (en) 1994-07-01 2003-06-10 Dana Farber Cancer Institute Methods for stimulating T cell responses by manipulating a common cytokine receptor γ chain
US5545527A (en) 1994-07-08 1996-08-13 Visible Genetics Inc. Method for testing for mutations in DNA from a patient sample
US5550020A (en) * 1994-07-08 1996-08-27 Visible Genetics Inc. Method, reagents and kit for diagnosis and targeted screening for retinoblastoma
SE9403953D0 (sv) * 1994-07-15 1994-11-16 Pharmacia Biotech Ab Sequence-based diagnosis
US5605796A (en) * 1994-07-19 1997-02-25 Behringwerke Ag Method for preventing amplification of nucleic acid contaminants in amplification mixtures using nuclease-receptor conjugates
NZ291621A (en) 1994-08-12 1998-09-24 Myriad Genetics Inc Isolation and detection of human breast cancer and ovarian cancer predisposing gene, brca1
NZ291624A (en) 1994-08-12 1998-07-28 Myriad Genetics Inc Method of diagnosis of a predisposition to breast cancer
CA2195562A1 (en) * 1994-08-19 1996-02-29 Pe Corporation (Ny) Coupled amplification and ligation method
ES2533860T3 (es) 1994-08-31 2015-04-15 E.I. Du Pont De Nemours And Company Secuencias de nucleótidos de genes de palmitoil-ACP tioesterasa de canola y soja y su uso en la regulación del contenido de ácidos grasos de los aceites de las plantas de soja y canola
US6455251B1 (en) 1994-09-13 2002-09-24 Thomas Jefferson University Methods of and kits and compositions for diagnosing colorectal tumors and metastasis thereof
US5582988A (en) * 1994-09-15 1996-12-10 Johnson & Johnson Clinical Diagnostics, Inc. Methods for capture and selective release of nucleic acids using weakly basic polymer and amplification of same
US5705366A (en) 1994-09-15 1998-01-06 Johnson & Johnson Clinical Diagnostics, Inc. Coamplification of target nucleic acids using volume exclusion agent in reaction composition, test kit and test device useful therefor
US5500341A (en) 1994-09-19 1996-03-19 Becton, Dickinson And Company Species-specific detection of Mycobacterium kansasii
US5538870A (en) * 1994-09-21 1996-07-23 Boehringer Mannheim Corporation Method for preparing nucleic acids for analysis and kits useful therefor
AT401270B (de) * 1994-09-26 1996-07-25 Immuno Ag Verfahren zur quantifizierung von genomischer dna
US7008771B1 (en) 1994-09-30 2006-03-07 Promega Corporation Multiplex amplification of short tandem repeat loci
CA2118048C (en) * 1994-09-30 2003-04-08 James W. Schumm Multiplex amplification of short tandem repeat loci
US6479235B1 (en) 1994-09-30 2002-11-12 Promega Corporation Multiplex amplification of short tandem repeat loci
US5843660A (en) * 1994-09-30 1998-12-01 Promega Corporation Multiplex amplification of short tandem repeat loci
US6013445A (en) * 1996-06-06 2000-01-11 Lynx Therapeutics, Inc. Massively parallel signature sequencing by ligation of encoded adaptors
US6613560B1 (en) 1994-10-19 2003-09-02 Agilent Technologies, Inc. PCR microreactor for amplifying DNA using microquantities of sample fluid
US6635226B1 (en) 1994-10-19 2003-10-21 Agilent Technologies, Inc. Microanalytical device and use thereof for conducting chemical processes
US8236493B2 (en) * 1994-10-21 2012-08-07 Affymetrix, Inc. Methods of enzymatic discrimination enhancement and surface-bound double-stranded DNA
US6309843B1 (en) 1994-10-25 2001-10-30 The Curators Of The University Of Missouri Glycoprotein for use in determining endometrial receptivity
FR2726277B1 (fr) 1994-10-28 1996-12-27 Bio Merieux Oligonucleotide utilisable comme amorce dans une methode d'amplification basee sur une replication avec deplacement de brin
DE69535830D1 (de) 1994-11-02 2008-10-16 Trophix Pharm Inc Natrium-ionenkanäle spezifisch für das periphäre nervensystem, dna welche diese kodiert, wirkstoff-suche und methoden zu deren herstellung und verwendung
US6410223B1 (en) 1994-11-04 2002-06-25 The United States Of America As Represented By The Secretary Of Agriculture Direct polymerase chain reaction assay, or bio-PCR
US5691132A (en) * 1994-11-14 1997-11-25 Cerus Corporation Method for inactivating pathogens in red cell compositions using quinacrine mustard
US5512441A (en) * 1994-11-15 1996-04-30 American Health Foundation Quantative method for early detection of mutant alleles and diagnostic kits for carrying out the method
US20030152909A1 (en) * 1994-11-16 2003-08-14 Mitrani Eduardo N. In vitro micro-organs, and uses related thereto
US5521299A (en) * 1994-11-22 1996-05-28 National Science Council Oligonucleotides for detection of baculovirus infection
DE4441626A1 (de) * 1994-11-23 1996-05-30 Boehringer Mannheim Gmbh Verfahren zum besonders sensitiven Nachweis von Nukleinsäuren
US6001610A (en) * 1994-11-23 1999-12-14 Roche Diagnostics, Gmbh Method for the particularly sensitive detection of nucleic acids
US5665545A (en) * 1994-11-28 1997-09-09 Akzo Nobel N.V. Terminal repeat amplification method
US5876940A (en) * 1994-11-30 1999-03-02 University Of Utah Research Foundation Alleles
US5652102A (en) * 1994-12-05 1997-07-29 The United States Of America As Represented By The Secretary Of Agriculture Assay for enterohemorrhagic Escherichia coli 0157:H7 by the polymerase chain reaction
US5830645A (en) 1994-12-09 1998-11-03 The Regents Of The University Of California Comparative fluorescence hybridization to nucleic acid arrays
EP0799888B1 (en) * 1994-12-09 2005-05-18 Wakunaga Seiyaku Kabushiki Kaisha Method of inhibiting non specific hybridization in primer extension
GB9425138D0 (en) 1994-12-12 1995-02-08 Dynal As Isolation of nucleic acid
IL114615A0 (en) 1995-07-16 1995-11-27 Yeda Res & Dev Modulators of the function of fas receptors and other proteins
CA2139070C (en) * 1994-12-23 2010-03-30 Burton W. Blais Method for enhancing detection ability of nucleic acid assays employing polymerase chain reaction
EP1260593A3 (en) * 1994-12-23 2003-12-03 Dade Behring Inc. Detection of nucleic acids by nuclease-catalyzed product formation
US6787304B1 (en) 1994-12-28 2004-09-07 Georgetown University Fluorometric assay for detecting nucleic acid cleavage
WO1996021144A1 (en) * 1994-12-30 1996-07-11 Georgetown University Fluorometric assay for detecting nucleic acid cleavage
US20030165908A1 (en) * 1994-12-30 2003-09-04 Georgetown University Fluorometric assay for detecting nucleic acid cleavage
US6015660A (en) * 1995-01-06 2000-01-18 The Regents Of The University Of California Borna disease viral sequences, diagnostics and therapeutics for nervous system diseases
US6077510A (en) * 1995-01-06 2000-06-20 Regents Of The University Of California Borna disease viral sequences, diagnostics and therapeutics for nervous system diseases
US5891629A (en) * 1995-09-28 1999-04-06 Ambion, Inc. Compositions for improving RNase cleavage of base pair mismatches in double-stranded nucleic acids
US5602011A (en) * 1995-01-18 1997-02-11 Pharmacia Biotech Inc. Purified Thermococcus barossii DNA polymerase
EP0805873B1 (en) * 1995-01-27 1999-09-01 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by The Secretary, Department of Health and Human Services Methods for sensitive detection of reverse transcriptase
US6949244B1 (en) 1995-12-20 2005-09-27 The Board Of Trustees Of The University Of Kentucky Murine monoclonal anti-idiotype antibody 11D10 and methods of use thereof
AR000862A1 (es) 1995-02-03 1997-08-06 Novozymes As Variantes de una ó-amilasa madre, un metodo para producir la misma, una estructura de adn y un vector de expresion, una celula transformada por dichaestructura de adn y vector, un aditivo para detergente, composicion detergente, una composicion para lavado de ropa y una composicion para la eliminacion del
US6015665A (en) * 1995-02-13 2000-01-18 The Regents Of The University Of Michigan Method and composition for regulating apoptosis
US6060238A (en) * 1995-02-13 2000-05-09 The Regents Of The University Of Michigan Method and composition for regulating apoptosis
US7097972B1 (en) 1995-02-13 2006-08-29 Regents Of The University Of Michigan Method and composition for regulating apoptosis
US6103465A (en) * 1995-02-14 2000-08-15 The Perkin-Elmer Corporation Methods and reagents for typing HLA class I genes
US5700683A (en) * 1995-02-17 1997-12-23 Pathogenesis Corporation Virulence-attenuating genetic deletions deleted from mycobacterium BCG
US5759783A (en) * 1995-03-14 1998-06-02 Ludwig Institute For Cancer Research Method of screening for cancer by detecting messenger RNA for a MAGE-XP gene
CN101173263A (zh) 1995-03-17 2008-05-07 诺沃奇梅兹有限公司 新的内切葡聚糖酶
US5837693A (en) * 1995-03-24 1998-11-17 The Regents Of The University Of California Intravenous hormone polypeptide delivery by salivary gland expression
US5885971A (en) * 1995-03-24 1999-03-23 The Regents Of The University Of California Gene therapy by secretory gland expression
US6531455B1 (en) 1995-03-24 2003-03-11 The Regents Of The University Of California Delivery of polynucleotides by secretory gland expression
US6653134B2 (en) * 1995-03-28 2003-11-25 Cp Hahnemann University Isolated stromal cells for use in the treatment of diseases of the central nervous system
US7807783B1 (en) 1995-04-03 2010-10-05 The Regents Of The University Of Michigan Methods and compositions for regulating FAS-associated apoptosis
US6312894B1 (en) 1995-04-03 2001-11-06 Epoch Pharmaceuticals, Inc. Hybridization and mismatch discrimination using oligonucleotides conjugated to minor groove binders
US5801155A (en) * 1995-04-03 1998-09-01 Epoch Pharmaceuticals, Inc. Covalently linked oligonucleotide minor grove binder conjugates
US5780222A (en) * 1995-04-10 1998-07-14 Alpha Therapeutic Corporation Method of PCR testing of pooled blood samples
US6416714B1 (en) 1995-04-25 2002-07-09 Discovery Partners International, Inc. Remotely programmable matrices with memories
US6017496A (en) * 1995-06-07 2000-01-25 Irori Matrices with memories and uses thereof
US5751629A (en) * 1995-04-25 1998-05-12 Irori Remotely programmable matrices with memories
US6329139B1 (en) 1995-04-25 2001-12-11 Discovery Partners International Automated sorting system for matrices with memory
US5874214A (en) * 1995-04-25 1999-02-23 Irori Remotely programmable matrices with memories
US6331273B1 (en) 1995-04-25 2001-12-18 Discovery Partners International Remotely programmable matrices with memories
US6221615B1 (en) * 1995-05-12 2001-04-24 Apoptosis Technology, Inc. Peptides and compositions which modulate apoptosis
US5629314A (en) * 1995-05-15 1997-05-13 Gaskin; Frances C. Methods and compositions for reducing pyrimidine photoproducts
US5777093A (en) 1995-05-16 1998-07-07 Ramot-University Authority For Applied Research & Industrial Development Ltd. cDNAs associated with ataxia-telangiectasia
US6586250B1 (en) 1995-05-16 2003-07-01 Washington University Method of PCR-based gene targeting
US5693467A (en) * 1995-05-19 1997-12-02 The American Type Culture Collection Mycoplasma polymerase chain reaction testing system using a set of mixed and single sequence primers
US5876949A (en) * 1995-05-31 1999-03-02 The Trustees Of The University Of Pennsylvania Antibodies specific for fragile X related proteins and method of using the same
US6177441B1 (en) 1995-06-05 2001-01-23 Cerus Corporation Treating red blood cell solutions with anti-viral agents
US5759776A (en) * 1995-06-05 1998-06-02 California Pacific Medical Center Targets for breast cancer diagnosis and treatment
US20040254101A1 (en) * 1995-06-06 2004-12-16 Human Genome Sciences, Inc. Colon specific gene and protein and cancer
US5861494A (en) 1995-06-06 1999-01-19 Human Genome Sciences, Inc. Colon specific gene and protein
US5916777A (en) * 1995-06-07 1999-06-29 Gen-Probe Incorporated Enzymatic synthesis of oligonucleotides using 3'-ribonucleotide primers
JPH11506605A (ja) * 1995-06-07 1999-06-15 アボツト・ラボラトリーズ 増幅反応におけるバックグラウンドを減少させるためにプローブをマスキングする方法
US5882867A (en) * 1995-06-07 1999-03-16 Dade Behring Marburg Gmbh Detection of nucleic acids by formation of template-dependent product
US6720140B1 (en) 1995-06-07 2004-04-13 Invitrogen Corporation Recombinational cloning using engineered recombination sites
US5710002A (en) * 1995-06-07 1998-01-20 Oregon State University Detection of Clavibacter michiganensis subsp. sepedonicus
ZA964896B (en) * 1995-06-07 1997-01-08 Connaught Lab Expression of lipoproteins
US5756459A (en) * 1995-06-07 1998-05-26 Fmc Corporation Insecticidally effective peptides isolatable from phidippus spider venom
US6001645A (en) * 1995-06-07 1999-12-14 Promega Corporation Thermophilic DNA polymerases from thermotoga neapolitana
US6077664A (en) * 1995-06-07 2000-06-20 Promega Corporation Thermophilic DNA polymerases from Thermotoga neapolitana
US7670823B1 (en) 1999-03-02 2010-03-02 Life Technologies Corp. Compositions for use in recombinational cloning of nucleic acids
US6143557A (en) * 1995-06-07 2000-11-07 Life Technologies, Inc. Recombination cloning using engineered recombination sites
US5932450A (en) * 1995-06-07 1999-08-03 Gen-Probe Incorporated Enzymatic synthesis of oligonucleotides using digestible templates
US5652126A (en) * 1995-06-07 1997-07-29 Gen-Probe Incorporated Use of restriction endonuclease sequences for cleaving phosphorothioate oligonucleotides
US5767376A (en) * 1995-06-07 1998-06-16 University Of Hawaii At Manoa Nucleic acids encoding a papaya ACC synthase gene
US5728526A (en) * 1995-06-07 1998-03-17 Oncor, Inc. Method for analyzing a nucleotide sequence
US5840490A (en) * 1995-06-07 1998-11-24 Mcmaster University Telomerase activity associated with hematological and colorectal malignancies
KR100463475B1 (ko) 1995-06-08 2005-06-22 로셰 디아그노스틱스 게엠베하 자기성피그먼트
DE19520398B4 (de) * 1995-06-08 2009-04-16 Roche Diagnostics Gmbh Magnetisches Pigment
AT402203B (de) * 1995-06-13 1997-03-25 Himmler Gottfried Dipl Ing Dr Verfahren zur transkriptionsfreien amplifizierung von nucleinsäuren
AU6113396A (en) 1995-06-14 1997-01-15 Regents Of The University Of California, The Novel high affinity human antibodies to tumor antigens
US6361951B1 (en) 1995-06-27 2002-03-26 The University Of North Carolina At Chapel Hill Electrochemical detection of nucleic acid hybridization
US6127127A (en) * 1995-06-27 2000-10-03 The University Of North Carolina At Chapel Hill Monolayer and electrode for detecting a label-bearing target and method of use thereof
US6132971A (en) * 1995-06-27 2000-10-17 The University Of North Carolina At Chapel Hill Microelectronic device
US6346387B1 (en) * 1995-06-27 2002-02-12 Xanthon, Inc. Detection of binding reactions using labels detected by mediated catalytic electrochemistry
DK0861261T3 (da) 1995-06-28 2009-12-14 Imp Cancer Res Tech Nukleotid- og proteinsekvenser af hvirveldyrs-Delta-gener og fremgangsmåder baseret derpå
WO1997003196A1 (en) 1995-07-11 1997-01-30 Magainin Pharmaceuticals Inc. CLONING, TISSUE DISTRIBUTION, AND FUNCTIONAL ANALYSIS OF Na+/H+ EXCHANGER ISOFORM, NHE3
US5989813A (en) * 1995-07-13 1999-11-23 Molecular Innovations, Inc. Detection of amplified nucleic acid sequences using bifunctional haptenization and dyed microparticles
WO1997003348A1 (en) * 1995-07-13 1997-01-30 Immunological Associates Of Denver Self-contained device integrating nucleic acid extraction, amplification and detection
US5821219A (en) * 1995-08-11 1998-10-13 Oregon Health Sciences University Opioid antagonists and methods of their use
US5759779A (en) * 1995-08-29 1998-06-02 Dehlinger; Peter J. Polynucleotide-array assay and methods
US6248555B1 (en) 1995-08-31 2001-06-19 The General Hospital Corporation Genetic alterations related to familial alzheimer's disease
CA2227306A1 (en) * 1995-09-01 1997-03-27 Ramot-University Authority For Applied Research And Industrial Developme Nt Ltd. Manipulation and detection of protein phosphatase 2c - pp2c.alpha. - expression in tumor cells for cancer therapy, prevention and detection
DE19533354C2 (de) * 1995-09-08 1999-07-01 Derya Dr Ozkan Verfahren und ihre Anwendungen um Nucleinsäuren sequenzspezifisch nachzuweisen und zu quantifizieren
US5750363A (en) * 1995-09-14 1998-05-12 Infectech, Inc. Method for determining the antimicrobial agent sensitivity of a nonparaffinophilic microorganism and an associated apparatus
US5663056A (en) * 1995-09-14 1997-09-02 Infectech, Inc. Method for determining the antimicrobial agent sensitivity of a nonparaffinophilic microorganism and an associated apparatus
US5854013A (en) * 1995-09-14 1998-12-29 Infectech, Inc. Method of determining the presence or absence of a nonparaffinophilic microorganism in a specimen
US5721112A (en) * 1995-09-14 1998-02-24 Infectech, Inc. Method of determining the presence or absence of a nonparaffinophilic microoganism in a specimen and an associated apparatus
US6911183B1 (en) * 1995-09-15 2005-06-28 The Regents Of The University Of Michigan Moving microdroplets
US6048734A (en) * 1995-09-15 2000-04-11 The Regents Of The University Of Michigan Thermal microvalves in a fluid flow method
US6130098A (en) * 1995-09-15 2000-10-10 The Regents Of The University Of Michigan Moving microdroplets
US6057149A (en) 1995-09-15 2000-05-02 The University Of Michigan Microscale devices and reactions in microscale devices
US7485440B2 (en) * 1995-09-27 2009-02-03 The United States Of America As Represented By The Department Of Health And Human Services Production of attenuated respiratory syncytial virus vaccines involving modification of M2 ORF2
US5637501A (en) * 1995-09-28 1997-06-10 Infectech, Inc. Apparatus for automatically testing the antibiotic sensitivity of a paraffinophilic microorganism
US5994062A (en) * 1995-10-02 1999-11-30 The United States Of America As Represented By The Department Of Health And Human Services Epithelial protein and DNA thereof for use in early cancer detection
US6165765A (en) 1995-10-18 2000-12-26 Shanghai Institute Of Biochemistry, Chinese Academy Of Sciences DNA polymerase having ability to reduce innate selective discrimination against fluorescent dye-labeled dideoxynucleotides
US6818431B1 (en) 1995-10-18 2004-11-16 Shanghai Mendel Dna Center Co. Ltd. DNA polymerase having ability to reduce innate selective discrimination against fluorescent dye-labeled dideoxynucleotides
US7455964B1 (en) 1996-07-15 2008-11-25 The Hospital For Sick Children Genes from the 20q13 amplicon and their uses
EP0864002A4 (en) * 1995-10-27 1999-07-28 Elliot R Ramberg METHODS AND COMPOSITIONS FOR DETECTION OF SPECIFIC NUCLEOTIDE SEQUENCES
US6015664A (en) * 1995-11-03 2000-01-18 Mcw Research Foundation Multiplex PCR assay using unequal primer concentrations to detect HPIV 1,2,3 and RSV A,B and influenza virus A, B
US5639675A (en) * 1995-11-09 1997-06-17 Infectech, Inc. Method of identifying a nonparaffinophilic microorganism using various milieus and an associated apparatus
DE19543065C2 (de) * 1995-11-09 2002-10-31 Gag Bioscience Gmbh Zentrum Fu Verfahren zur Genomanalyse und Mittel zur Durchführung des Verfahrens
US5641645A (en) * 1995-11-09 1997-06-24 Infectech, Inc. Method for determining the antimicrobial agent sensitivity of a nonparaffinophilic microorganism using various milieus and an associated apparatus
US5707824A (en) * 1995-11-09 1998-01-13 Infectech, Inc. Method of determining the presence or absence of a paraffinophilic microorganism
ZA962161B (en) * 1995-11-09 1996-09-26 Infectech Inc Method for determining the antimicrobial agent sensitivity of a paraffinophilic microorganism using various milieus and an associated apparatus
US5772889A (en) * 1995-11-13 1998-06-30 Transgenomic, Inc. System and method for performing nucleic acid separations using liquid chromatography
US6066258A (en) * 1997-12-05 2000-05-23 Transgenomic, Inc. Polynucleotide separations on polymeric separation media
US6355791B1 (en) 1995-11-13 2002-03-12 Transgenomic, Inc. Polynucleotide separations on polymeric separation media
AU1867397A (en) 1995-11-16 1997-06-05 Michael W. Dahm Method of quantifying tumour cells in a body fluid and a suitable test kit
WO1997019193A2 (en) 1995-11-21 1997-05-29 Yale University Unimolecular segment amplification and detection
US5854033A (en) 1995-11-21 1998-12-29 Yale University Rolling circle replication reporter systems
US5763263A (en) * 1995-11-27 1998-06-09 Dehlinger; Peter J. Method and apparatus for producing position addressable combinatorial libraries
US5837442A (en) 1995-11-29 1998-11-17 Roche Molecular Systems, Inc. Oligonucleotide primers for amplifying HCV nucleic acid
US6136530A (en) * 1995-11-29 2000-10-24 Texas Tech University Health Sciences Center Compositions and methods for assessing risk factors in Alzheimer's disease
US5801064A (en) * 1995-12-04 1998-09-01 Foresman; Mark D. Assay methods and reagents for detecting autoantibodies
DK0868530T3 (da) 1995-12-05 2003-07-21 Jorn Erland Koch Kaskade-nucleinsyreamplificeringsreaktion
US20020164580A1 (en) * 1995-12-07 2002-11-07 Diversa Corporation Combinatorial screening of mixed populations of organisms
US6713279B1 (en) 1995-12-07 2004-03-30 Diversa Corporation Non-stochastic generation of genetic vaccines and enzymes
US6939689B2 (en) 1995-12-07 2005-09-06 Diversa Corporation Exonuclease-mediated nucleic acid reassembly in directed evolution
US6740506B2 (en) 1995-12-07 2004-05-25 Diversa Corporation End selection in directed evolution
US6537776B1 (en) 1999-06-14 2003-03-25 Diversa Corporation Synthetic ligation reassembly in directed evolution
US20020028443A1 (en) * 1999-09-27 2002-03-07 Jay M. Short Method of dna shuffling with polynucleotides produced by blocking or interrupting a synthesis or amplification process
US6358709B1 (en) 1995-12-07 2002-03-19 Diversa Corporation End selection in directed evolution
US5965408A (en) 1996-07-09 1999-10-12 Diversa Corporation Method of DNA reassembly by interrupting synthesis
US6361974B1 (en) * 1995-12-07 2002-03-26 Diversa Corporation Exonuclease-mediated nucleic acid reassembly in directed evolution
US7018793B1 (en) * 1995-12-07 2006-03-28 Diversa Corporation Combinatorial screening of mixed populations of organisms
US5910434A (en) 1995-12-15 1999-06-08 Systemix, Inc. Method for obtaining retroviral packaging cell lines producing high transducing efficiency retroviral supernatant
US6048688A (en) * 1996-11-12 2000-04-11 Kimberly-Clark Corporation Method for detection of Pseudomonas aeruginosa using polymerase chain reaction
US5837492A (en) 1995-12-18 1998-11-17 Myriad Genetics, Inc. Chromosome 13-linked breast cancer susceptibility gene
IL124620A0 (en) 1995-12-18 1998-12-06 Myriad Genetics Inc Chromosome 13-linked breast cancer susceptibility gene
US5888736A (en) * 1995-12-22 1999-03-30 Visible Genetics, Inc. Method, compositions and kit for detection and identification of microorganisms
US5795722A (en) * 1997-03-18 1998-08-18 Visible Genetics Inc. Method and kit for quantitation and nucleic acid sequencing of nucleic acid analytes in a sample
US6007983A (en) * 1995-12-22 1999-12-28 Visible Genetics Inc. Method and kit for evaluation of HIV mutations
US6265152B1 (en) 1995-12-22 2001-07-24 Visible Genetics Inc. Method and kit for evaluation of HIV mutations
US5710003A (en) * 1996-01-18 1998-01-20 Thomas Jefferson University Diagnostic test to determine the malignancy of smooth muscle tumors
US6613508B1 (en) 1996-01-23 2003-09-02 Qiagen Genomics, Inc. Methods and compositions for analyzing nucleic acid molecules utilizing sizing techniques
US6027890A (en) * 1996-01-23 2000-02-22 Rapigene, Inc. Methods and compositions for enhancing sensitivity in the analysis of biological-based assays
US6312893B1 (en) * 1996-01-23 2001-11-06 Qiagen Genomics, Inc. Methods and compositions for determining the sequence of nucleic acid molecules
EP0880598A4 (en) 1996-01-23 2005-02-23 Affymetrix Inc RAPID EVALUATION OF NUCLEIC ACID ABUNDANCE DIFFERENCE, WITH A HIGH-DENSITY OLIGONUCLEOTIDE SYSTEM
US7256020B2 (en) * 1996-11-29 2007-08-14 Third Wave Technologies, Inc. Methods and compositions for detecting target sequences
US7195871B2 (en) * 1996-01-24 2007-03-27 Third Wave Technologies, Inc Methods and compositions for detecting target sequences
US6875572B2 (en) 1996-01-24 2005-04-05 Third Wave Technologies, Inc. Nucleic acid detection assays
US6706471B1 (en) * 1996-01-24 2004-03-16 Third Wave Technologies, Inc. Detection of nucleic acid sequences by invader-directed cleavage
US6562611B1 (en) 1996-11-29 2003-05-13 Third Wave Technologies, Ins. FEN-1 endonucleases, mixtures and cleavage methods
US7122364B1 (en) 1998-03-24 2006-10-17 Third Wave Technologies, Inc. FEN endonucleases
US20080160524A1 (en) * 1996-01-24 2008-07-03 Third Wave Technologies, Inc. Methods and Compositions for Detecting Target Sequences
US5985557A (en) 1996-01-24 1999-11-16 Third Wave Technologies, Inc. Invasive cleavage of nucleic acids
US6090606A (en) * 1996-01-24 2000-07-18 Third Wave Technologies, Inc. Cleavage agents
US5763184A (en) 1996-01-30 1998-06-09 Roche Molecular Systems, Inc. Nucleotide sequence variation in the ABO glycosyltransferase gene
US5994143A (en) * 1996-02-01 1999-11-30 Abbott Laboratories Polymeric fluorophores enhanced by moieties providing a hydrophobic and conformationally restrictive microenvironment
US7070962B1 (en) * 1996-02-01 2006-07-04 Aventis Pharmaceuticals Inc. Positive controls in polynucleotide amplification
US5955322A (en) * 1996-02-07 1999-09-21 Mount Sinai School Of Medicine Of The City University Of New York DNA-based computer
US6852487B1 (en) 1996-02-09 2005-02-08 Cornell Research Foundation, Inc. Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays
EP2573101B1 (en) 1996-02-09 2016-04-20 Cornell Research Foundation, Inc. Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays
US20020150921A1 (en) * 1996-02-09 2002-10-17 Francis Barany Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays
US20030022184A1 (en) * 1996-02-12 2003-01-30 Oncormed. Inc. Coding sequences of the human BRCA1 gene
US5789201A (en) * 1996-02-23 1998-08-04 Cocensys, Inc. Genes coding for bcl-y a bcl-2 homologue
US6255064B1 (en) 1996-03-01 2001-07-03 The Procter & Gamble Company Disintegrin metalloprotease and its use
CA2246238A1 (en) * 1996-03-01 1997-09-04 E.I. Du Pont De Nemours And Company A method for the amplification and detection of a nucleic acid fragment of interest
DE69717092T2 (de) 1996-03-01 2003-07-24 Novo Nordisk As Gebrauch einer pharmazeutischen Zusammensetzung, enthaltend ein appetitzügelndes Peptid
CA2199213C (en) 1996-03-11 2007-04-17 John Wesley Backus Amplifying and detecting target nucleic acids using a post amplification incubation step
AU723678B2 (en) * 1996-03-18 2000-08-31 Molecular Biology Resources, Inc. Target nucleic acid sequence amplification
US5882644A (en) * 1996-03-22 1999-03-16 Protein Design Labs, Inc. Monoclonal antibodies specific for the platelet derived growth factor β receptor and methods of use thereof
US6777217B1 (en) * 1996-03-26 2004-08-17 President And Fellows Of Harvard College Histone deacetylases, and uses related thereto
US6140305A (en) * 1996-04-04 2000-10-31 Bio-Rad Laboratories, Inc. Hereditary hemochromatosis gene products
US7026116B1 (en) 1996-04-04 2006-04-11 Bio-Rad Laboratories, Inc. Polymorphisms in the region of the human hemochromatosis gene
US6458530B1 (en) * 1996-04-04 2002-10-01 Affymetrix Inc. Selecting tag nucleic acids
EP1997900A3 (en) 1996-04-05 2010-10-06 Novartis Vaccines and Diagnostics, Inc. Recombinant alphavirus-based vectors with reduced inhibition of cellular macromolecular synthesis
US5919901A (en) * 1996-04-08 1999-07-06 Bayer Corporation Neuropeptide Y receptor Y5 and nucleic acid sequences
US5965392A (en) 1996-04-08 1999-10-12 Bayer Corporation Neuropeptide Y receptor Y5 and nucleic acid sequences
US5776683A (en) * 1996-07-11 1998-07-07 California Pacific Medical Center Methods for identifying genes amplified in cancer cells
US7223535B2 (en) * 1996-04-19 2007-05-29 Centers For Disease Control Synthetic peptides immunoreactive with hepatitis A virus antibodies
ZA973367B (en) * 1996-04-19 1997-11-18 Innogenetics Nv Method for typing and detecting HBV.
US5712127A (en) 1996-04-29 1998-01-27 Genescape Inc. Subtractive amplification
CN1246455C (zh) 1996-04-30 2006-03-22 诺沃奇梅兹有限公司 α－淀粉酶变体
US6413718B1 (en) 1996-05-01 2002-07-02 Visible Genetics Inc. Method for sequencing of nucleic acid polymers
US5776746A (en) * 1996-05-01 1998-07-07 Genitope Corporation Gene amplification methods
WO1997042506A1 (en) 1996-05-03 1997-11-13 Thomas Jefferson University Methods of and kits and compositions for diagnosing colorectal tumors and metastasis thereof
HU224827B1 (hu) 1996-05-03 2006-02-28 Abbott Lab Új antiangiogén peptidek, azokat kódoló polinukleotidok, és eljárások angiogenezis gátlására
EP0953052B1 (en) 1996-05-06 2009-03-04 Oxford BioMedica (UK) Limited Crossless retroviral vectors
US6436638B1 (en) 1996-05-09 2002-08-20 Metropolitan Water District Of Southern California Cryptosporidium detection method
US5811239A (en) * 1996-05-13 1998-09-22 Frayne Consultants Method for single base-pair DNA sequence variation detection
WO1997043448A2 (en) * 1996-05-13 1997-11-20 G.D. Searle & Co. Analysis of expression of rat cytochrome p450 isoenzymes and phase ii conjugating enzymes
US6455248B1 (en) 1996-05-20 2002-09-24 Miami University Reagents and kits for detecting fungal pathogens in a biological sample
US5910409A (en) * 1996-05-20 1999-06-08 Miami University Methods and reagents for detecting fungal pathogens in a biological sample
US5948889A (en) 1996-05-21 1999-09-07 Case Western Reserve University Compositions and methods for screening antimicrobials
US6207153B1 (en) * 1996-05-22 2001-03-27 Viventia Biotech, Inc. Antigen binding fragments that specifically detect cancer cells, nucleotides encoding the fragments, and use thereof for the prophylaxis and detection of cancers
US6849399B1 (en) 1996-05-23 2005-02-01 Bio-Rad Laboratories, Inc. Methods and compositions for diagnosis and treatment of iron misregulation diseases
WO1997045559A1 (en) 1996-05-29 1997-12-04 Cornell Research Foundation, Inc. Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions
AU736742B2 (en) 1996-06-03 2001-08-02 Governors Of The University Of Alberta, The Methods for detection of rearranged DNA
CA2591550C (en) 1996-06-04 2009-04-28 University Of Utah Research Foundation Monitoring hybridization during pcr
US20020115585A1 (en) * 1996-06-07 2002-08-22 Hei Derek J. Method and devices for the removal of psoralens from blood products
US6780982B2 (en) * 1996-07-12 2004-08-24 Third Wave Technologies, Inc. Charge tags and the separation of nucleic acid molecules
CN101012454B (zh) 1996-07-15 2011-11-16 美国政府健康及人类服务部 从克隆的核苷酸序列制备减毒呼吸道合胞病毒疫苗的方法
US6117635A (en) * 1996-07-16 2000-09-12 Intergen Company Nucleic acid amplification oligonucleotides with molecular energy transfer labels and methods based thereon
US5866336A (en) * 1996-07-16 1999-02-02 Oncor, Inc. Nucleic acid amplification oligonucleotides with molecular energy transfer labels and methods based thereon
US6312892B1 (en) * 1996-07-19 2001-11-06 Cornell Research Foundation, Inc. High fidelity detection of nucleic acid differences by ligase detection reaction
US20020106647A1 (en) * 1996-07-24 2002-08-08 Segal Andrew H. Nucleic acid compositions and methods of introducing nucleic acids into cells
US20020137917A1 (en) * 1996-07-26 2002-09-26 University Of Maryland Biotechnology Institute Assay for perkinsus in shellfish
US5853990A (en) * 1996-07-26 1998-12-29 Edward E. Winger Real time homogeneous nucleotide assay
US6277592B1 (en) 1996-07-31 2001-08-21 Purina Mills, Inc. Porcine leptin protein, nucleic acid sequences coding therefor and uses thereof
US6297027B1 (en) 1996-07-31 2001-10-02 Purina Mills, Inc. Bovine leptin protein, nucleic acid sequences coding therefor and uses thereof
AU4065397A (en) 1996-08-14 1998-03-06 Life Technologies, Inc. Stable compositions for nucleic acid amplification and sequencing
US6132954A (en) * 1996-08-20 2000-10-17 Baylor College Of Medicine Methods of screening for agents that delay a cell cycle and compositions comprising era and an analogue of wild-type era
US20050064439A1 (en) * 1996-08-22 2005-03-24 Johanna Bergmann Agents for pre-symptomatic detection and therapeutic targeting of alzheimer's disease and down syndrome in humans
DE122009000079I2 (de) 1996-08-30 2011-06-16 Novo Nordisk As Novo Alle Glp-1 derivate
DE19637339A1 (de) * 1996-09-13 1998-03-19 Hoechst Ag Verfahren zur Amplifikation von Nukleinsäuren
US6312930B1 (en) 1996-09-16 2001-11-06 E. I. Du Pont De Nemours And Company Method for detecting bacteria using PCR
WO1998012332A1 (en) 1996-09-17 1998-03-26 Chiron Corporation Compositions and methods for treating intracellular diseases
US5981274A (en) * 1996-09-18 1999-11-09 Tyrrell; D. Lorne J. Recombinant hepatitis virus vectors
US5965703A (en) * 1996-09-20 1999-10-12 Idun Pharmaceuticals Human bad polypeptides, encoding nucleic acids and methods of use
US6071493A (en) 1996-09-20 2000-06-06 Baylor College Of Medicine Method of screening for an agent that inhibits mononuclear phagocyte-plaque component complex formation
US6361940B1 (en) 1996-09-24 2002-03-26 Qiagen Genomics, Inc. Compositions and methods for enhancing hybridization and priming specificity
US5989873A (en) * 1996-09-24 1999-11-23 Vinayagamoorthy; Thuraiayah Method of detecting gene expression and/or of preventing such expression in cells
US6093695A (en) 1996-09-26 2000-07-25 Monsanto Company Bacillus thuringiensis CryET29 compositions toxic to coleopteran insects and ctenocephalides SPP
US6218437B1 (en) 1996-09-30 2001-04-17 The Regents Of The University Of California Treatment and prevention of hepatic disorders
US6475789B1 (en) 1996-10-01 2002-11-05 University Technology Corporation Human telomerase catalytic subunit: diagnostic and therapeutic methods
US6093809A (en) 1996-10-01 2000-07-25 University Technology Corporation Telomerase
US6261836B1 (en) 1996-10-01 2001-07-17 Geron Corporation Telomerase
US7585622B1 (en) 1996-10-01 2009-09-08 Geron Corporation Increasing the proliferative capacity of cells using telomerase reverse transcriptase
JP3869092B2 (ja) 1996-10-01 2007-01-17 ジェロン・コーポレーション ヒトテロメラーゼ触媒性サブユニット
US6610839B1 (en) * 1997-08-14 2003-08-26 Geron Corporation Promoter for telomerase reverse transcriptase
US6808880B2 (en) 1996-10-01 2004-10-26 Geron Corporation Method for detecting polynucleotides encoding telomerase
EP0834569A1 (en) 1996-10-03 1998-04-08 Roche Diagnostics GmbH Thermostable DNA polymerase from carboxydothermus hydrogenoformans
EP0834571A1 (en) * 1996-10-03 1998-04-08 Roche Diagnostics GmbH Thermostable nucleic acid polymerase from Thermococcus gorgonarius
US6855545B1 (en) 1996-10-04 2005-02-15 Lexicon Genetics Inc. Indexed library of cells containing genomic modifications and methods of making and utilizing the same
US6207371B1 (en) 1996-10-04 2001-03-27 Lexicon Genetics Incorporated Indexed library of cells containing genomic modifications and methods of making and utilizing the same
US6139833A (en) * 1997-08-08 2000-10-31 Lexicon Genetics Incorporated Targeted gene discovery
US6136566A (en) * 1996-10-04 2000-10-24 Lexicon Graphics Incorporated Indexed library of cells containing genomic modifications and methods of making and utilizing the same
US7332338B2 (en) 1996-10-04 2008-02-19 Lexicon Pharmaceuticals, Inc. Vectors for making genomic modifications
US5919638A (en) * 1996-10-08 1999-07-06 Abbott Laboratories Reagents and methods useful for detecting prostate tumors
US20040072243A1 (en) * 1996-10-11 2004-04-15 Lexicon Genetics Incorporated Indexed library of cells containing genomic modifications and methods of making and utilizing the same
US5814453A (en) * 1996-10-15 1998-09-29 Novartis Finance Corporation Detection of fungal pathogens using the polymerase chain reaction
ATE318906T1 (de) 1996-10-16 2006-03-15 Zymogenetics Inc Fibroblasten-wachstumsfaktoren homologefibroblasten-wachstumsfaktoren homologe
US6242669B1 (en) 1996-10-30 2001-06-05 Mycogen Corporation Pesticidal toxins and nucleotide sequences which encode these toxins
US20030165971A1 (en) * 1996-10-31 2003-09-04 Billing-Medel Patricia A. Reagents and methods useful for detecting diseases of the breast
US20050153373A1 (en) * 1996-10-31 2005-07-14 Billing-Medel Patricia A. Reagents and methods useful for detecting diseases of the breast
US20050202499A1 (en) 1996-10-31 2005-09-15 Billing-Medel Patricia A. Reagents and methods useful for detecting diseases of the breast
US5863731A (en) * 1996-11-01 1999-01-26 The Penn State Research Foundation Polymerase chain reaction-based diagnostic test for the detection of Xanthomonas campestris pathovar pelargonii
US5800997A (en) * 1996-11-01 1998-09-01 Novartis Finance Corporation Detection of maize fungal pathogens using the polymerase chain reaction
US6096273A (en) * 1996-11-05 2000-08-01 Clinical Micro Sensors Electrodes linked via conductive oligomers to nucleic acids
US7381525B1 (en) * 1997-03-07 2008-06-03 Clinical Micro Sensors, Inc. AC/DC voltage apparatus for detection of nucleic acids
US6066778A (en) * 1996-11-06 2000-05-23 The Regents Of The University Of Michigan Transgenic mice expressing APC resistant factor V
US20030129589A1 (en) * 1996-11-06 2003-07-10 Hubert Koster Dna diagnostics based on mass spectrometry
US6287822B1 (en) 1997-08-05 2001-09-11 Transgenomic, Inc. Mutation detection method
US6030527A (en) * 1996-11-13 2000-02-29 Transgenomic, Inc. Apparatus for performing polynucleotide separations using liquid chromatography
US5997742A (en) * 1996-11-13 1999-12-07 Transgenomic, Inc. Method for performing polynucleotide separations using liquid chromatography
US6372142B1 (en) 1996-11-13 2002-04-16 Transgenomic, Inc. Column for DNA separation by matched ion polynucleotide chromatography
US6482317B2 (en) 1996-11-13 2002-11-19 Transgenomic, Inc. Polynucleotide separations on polymeric separation media
US6174441B1 (en) 1996-11-13 2001-01-16 Transgenomic, Inc. Method for performing polynucleotide separations using liquid chromatography
US7138518B1 (en) 1996-11-13 2006-11-21 Transgenomic, Inc. Liquid chromatographic separation of polynucleotides
US6471866B1 (en) 1996-11-13 2002-10-29 Transgenomic, Inc. Process for performing polynucleotide separations
US6017457A (en) * 1996-11-13 2000-01-25 Transgenomic, Inc. Method for performing polynucleotide separations using liquid chromatography
US5972222A (en) * 1996-11-13 1999-10-26 Transgenomic, Inc. Process for performing polynucleotide separations
US6291164B1 (en) * 1996-11-22 2001-09-18 Invitrogen Corporation Methods for preventing inhibition of nucleic acid synthesis by pyrophosphate
US6077680A (en) * 1996-11-27 2000-06-20 The University Of Florida ShK toxin compositions and methods of use
EP0963443B1 (en) 1996-12-10 2006-03-08 Sequenom, Inc. Releasable nonvolatile mass-label molecules
US6495692B1 (en) * 1996-12-10 2002-12-17 Abbott Laboratories Helium-neon excitable reticulocyte dyes derivable from halolepidines
EP0951536B1 (en) * 1996-12-12 2007-01-24 Yissum Research Development Company Of The Hebrew University Of Jerusalem Synthetic antisense oligodeoxynucleotides and pharmaceutical compositions containing them
US6017701A (en) * 1996-12-13 2000-01-25 Stratgene Methods and adaptors for generating specific nucleic acid populations
WO1998029569A1 (en) * 1996-12-13 1998-07-09 Stratagene Methods and adaptors for generating specific nucleic acid populations
US20070009930A1 (en) * 1996-12-18 2007-01-11 Maxygen, Inc. Methods and compositions for polypeptide engineering
US6605428B2 (en) * 1996-12-20 2003-08-12 Roche Diagnostics Gmbh Method for the direct, exponential amplification and sequencing of DNA molecules and its application
DE19653494A1 (de) * 1996-12-20 1998-06-25 Svante Dr Paeaebo Verfahren zur entkoppelten, direkten, exponentiellen Amplifikation und Sequenzierung von DNA Molekülen unter Zugabe einer zweiten thermostabilen DNA Polymerase und dessen Anwendung
DE19653439A1 (de) * 1996-12-20 1998-07-02 Svante Dr Paeaebo Verfahren zur direkten, exponentiellen Amplifikation und Sequenzierung von DNA Molekülen und dessen Anwendung
US5861295A (en) * 1997-01-02 1999-01-19 Life Technologies, Inc. Nucleic acid-free thermostable enzymes and methods of production thereof
US5851805A (en) * 1997-01-16 1998-12-22 Board Of Trustees Operating Michigan State University Method for producing DNA from mRNA
US20050287583A1 (en) * 1997-01-21 2005-12-29 Promega Corporation Methods and kits for isolating biological target materials using silica magnetic particles
US6027945A (en) 1997-01-21 2000-02-22 Promega Corporation Methods of isolating biological target materials using silica magnetic particles
US6171788B1 (en) 1997-01-28 2001-01-09 The Regents Of The University Of California Methods for the diagnosis, prognosis and treatment of glaucoma and related disorders
US7138511B1 (en) 1997-01-28 2006-11-21 The Regents Of The University Of California Nucleic acids, kits and methods for the diagnosis, prognosis and treatment of glaucoma and related disorders
US6475724B1 (en) * 1997-01-28 2002-11-05 The Regents Of The University Of California Nucleic acids, kits, and methods for the diagnosis, prognosis and treatment of glaucoma and related disorders
US6262242B1 (en) 1997-01-30 2001-07-17 Board Of Regents, The University Of Texas System Tumor suppressor designated TS10Q23.3
AU752985B2 (en) 1997-01-31 2002-10-03 Xy, Llc. Optical apparatus
US5952200A (en) * 1997-02-06 1999-09-14 University Of South Carolina Method of diagnosing cancer in human cells using a reverse transcriptase-polymerase chain reaction for identifying the presence of stromelysin-3
CA2279231C (en) 1997-02-07 2013-11-26 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Activity dependent neurotrophic factor iii (adnf iii)
IL131332A (en) 1997-02-12 2003-07-31 Eugene Y Chan Methods and products for analyzing polymers
US6187536B1 (en) 1997-02-18 2001-02-13 Thomas Jefferson University Methods of identifying and detecting pancreatic cancer
US6713300B1 (en) * 1997-02-27 2004-03-30 University Of Utah Research Foundation Nucleic acid and amino acid sequences for ATP-binding cassette transporter and methods of screening for agents that modify ATP-binding cassette transporter
US5851808A (en) * 1997-02-28 1998-12-22 Baylor College Of Medicine Rapid subcloning using site-specific recombination
US6524795B1 (en) 1997-03-10 2003-02-25 Interleukin Genetics, Inc. Diagnostics for cardiovascular disorders
WO1998039967A1 (en) * 1997-03-12 1998-09-17 The General Hospital Corporation A method for treating or preventing alzheimer's disease
US6830887B2 (en) 1997-03-18 2004-12-14 Bayer Healthcare Llc Method and kit for quantitation and nucleic acid sequencing of nucleic acid analytes in a sample
US6268165B1 (en) 1997-03-19 2001-07-31 The Board Of Trustees Of The University Of Arkansas Methods for the early diagnosis of ovarian cancer
DE69838724T2 (de) 1997-03-21 2008-10-30 Stratagene California, La Jolla Polymerase-verbessernder faktor (pef)-enthaltende extrakte, pef proteinkomplexe, isoliertes pef protein und verfahren zur reinigung und identifizierung
US5958738A (en) 1997-03-24 1999-09-28 Roche Diagnostics Corporation Procedure for subtractive hybridization and difference analysis
US6153410A (en) * 1997-03-25 2000-11-28 California Institute Of Technology Recombination of polynucleotide sequences using random or defined primers
US5939316A (en) * 1997-03-27 1999-08-17 Millennium Pharmaceuticals, Inc. Chromosome 18 marker
US5866412A (en) * 1997-03-27 1999-02-02 Millennium Pharmaceuticals, Inc. Chromosome 18 marker
US5955355A (en) * 1997-03-27 1999-09-21 Millennium Pharmaceuticals, Inc. Chromosome 18 marker
US6048689A (en) * 1997-03-28 2000-04-11 Gene Logic, Inc. Method for identifying variations in polynucleotide sequences
US20020137904A1 (en) * 1998-03-27 2002-09-26 Patricia A. Billing-Medel Reagents and methods useful for detecting diseases of the gastrointestinal tract
EP2354251B1 (en) 1997-04-03 2014-10-15 Life Technologies Corporation Compositons and methods for reverse transcriptase-Polymerase chain reaction (RT-PCR)
EP0972082A4 (en) 1997-04-04 2007-04-25 Caliper Life Sciences Inc BIOCHEMICAL ANALYZERS OPERATING IN CLOSED LOOP
ATE220502T1 (de) * 1997-04-09 2002-08-15 Danisco Verbessertes verfahren zur herstellung von mehlteigwaren sowie produkte hergestellt aus solchen teigwaren unter verwendung von glyzerinoxidase
EP2060630B1 (en) 1997-04-10 2012-10-24 Stichting Katholieke Universiteit University Medical Centre Nijmegen PCA3, PCA3 genes, and methods of use
US6054567A (en) 1997-04-11 2000-04-25 The United States Of America As Represented By The Department Of Health And Human Services Recombinant proteins of a pakistani strain of hepatitis E and their use in diagnostic methods and vaccines
US6387615B2 (en) * 1997-04-11 2002-05-14 Isis Innovation Limited Methods and materials for the diagnosis or prognosis of asthma
US6080911A (en) * 1997-04-15 2000-06-27 Ohio University Mice models of growth hormone insensitivity
WO1998046260A1 (en) 1997-04-15 1998-10-22 Baylor College Of Medicine Pasteurella haemolytica vaccine
US6716625B1 (en) 1997-04-16 2004-04-06 Claude Selitrennikoff Histidine kinases of Aspergillus and other fungal species, related compositions, and methods of use
US5939306A (en) * 1997-04-16 1999-08-17 University Technology Corporation Osmosensing histidine kinases
EP0975755B2 (en) 1997-04-16 2011-08-03 Millennium Pharmaceuticals, Inc. Crsp protein (cysteine-rich secreted proteins), nucleic acid molecules encoding them and uses therefor
US7413864B2 (en) * 1997-04-18 2008-08-19 Geron Corporation Treating cancer using a telomerase vaccine
US7622549B2 (en) 1997-04-18 2009-11-24 Geron Corporation Human telomerase reverse transcriptase polypeptides
CA2287542A1 (en) 1997-04-22 1998-10-29 Life Technologies, Inc. Methods for the production of aslv reverse transcriptases composed of multiple subunits
JP2001522244A (ja) 1997-04-24 2001-11-13 ユニバーシティ オブ ワシントン パルボウイルスベクターによる標的化した遺伝子改変
US20050208567A1 (en) * 1997-04-25 2005-09-22 Billing-Medel Patricia A Reagents and methods useful for detecting diseases of the prostate
AU7265298A (en) * 1997-04-29 1998-11-24 Trustees Of Boston University Methods and compositions for targeted dna differential display
EP1905357B1 (en) 1997-04-30 2012-11-28 The Board Of Trustees Of The Leland Stanford Junior University Method of imaging cell death in vivo
US6551814B1 (en) 1997-05-05 2003-04-22 Ohio University Methods for bioremediation by degrading toluene
US6395539B1 (en) 1997-05-05 2002-05-28 Ohio University Composition and methods for bioremediation
US7115722B1 (en) 1997-05-22 2006-10-03 Viventia Biotech, Inc. Antigen binding fragments that specifically detect cancer cells, nucleotides encoding the fragments, and use thereof for the prophylaxis and detection of cancers
US7632508B2 (en) * 1997-05-23 2009-12-15 The United States Of America Attenuated human-bovine chimeric parainfluenza virus (PIV) vaccines
US20030082209A1 (en) * 2000-07-05 2003-05-01 Skiadopoulos Mario H. Attenuated human-bovine chimeric parainfluenza virus (PIV) vaccines
US7951383B2 (en) * 1997-05-23 2011-05-31 The United States Of America As Represented By The Department Of Health And Human Services Attenuated parainfluenza virus (PIV) vaccines
DE69835519T2 (de) 1997-06-13 2007-04-05 Bio-Rad Laboratories, Inc., Hercules Verfahren und zusammensetzungen für die diagnose und die behandlung von krankheiten, die mit eisenüberschuss oder eisenmangel assoziiert sind.
US20020098190A1 (en) * 1997-06-13 2002-07-25 Malaya Chatterjee Compositions and methods for treating tumors bearing HMFG and CEA antigens
US6406857B1 (en) 1997-06-16 2002-06-18 Exact Sciences Corporation Methods for stool sample preparation
US5962665A (en) * 1997-06-16 1999-10-05 Abbott Laboratories Nucleic acid primers and probes for detecting HIV-1 and HIV-2
US6046165A (en) * 1997-06-23 2000-04-04 Ophidian Pharmaceuticals, Inc. Compositions and methods for identifying and testing TGF-β pathway agonists and antagonists
AU8162598A (en) * 1997-06-25 1999-01-04 Life Technologies, Inc. Improved method for isolating and recovering target dna or rna molecules having a desired nucleotide sequence
US6258534B1 (en) 1998-03-02 2001-07-10 Bbi Bioseq, Inc. Pressure-controlled nucleic acid hybridization
TR200000443T2 (tr) * 1997-07-09 2000-09-21 Akzo Nobel N.V. Çelatlama maddeleri ve manganik çelatları.
US20040005542A1 (en) 2001-06-22 2004-01-08 Krempl Christine D Respiratory syncytial virus vaccines expressing protective antigens from promotor- proximal genes
US20030157642A1 (en) 1997-07-15 2003-08-21 Caldwell Robert M. Increasing production of proteins in gram-positive microorganisms
US7662397B2 (en) * 1997-07-15 2010-02-16 The United States Of America As Represented By The Department Of Health And Human Services Respiratory syncytial virus vaccines expressing protective antigens from promoter-proximal genes
US5874589A (en) * 1997-07-18 1999-02-23 Glaxo Wellcome, Inc. Methods for synthesizing diverse collections of tetramic acids and derivatives thereof
US6548642B1 (en) * 1997-07-21 2003-04-15 Ohio University Synthetic genes for plant gums
US7378506B2 (en) * 1997-07-21 2008-05-27 Ohio University Synthetic genes for plant gums and other hydroxyproline-rich glycoproteins
US6639050B1 (en) 1997-07-21 2003-10-28 Ohio University Synthetic genes for plant gums and other hydroxyproline-rich glycoproteins
US6570062B1 (en) * 1997-07-21 2003-05-27 Ohio University Synthetic genes for plant gums and other hydroxyproline-rich glycoproteins
US6420108B2 (en) 1998-02-09 2002-07-16 Affymetrix, Inc. Computer-aided display for comparative gene expression
US20040161409A1 (en) * 1997-07-25 2004-08-19 Kurtzman Gary J. Induction of immune response to antigens expressed by recombinant adeno-associated virus
US6826296B2 (en) 1997-07-25 2004-11-30 Affymetrix, Inc. Method and system for providing a probe array chip design database
WO1999005591A2 (en) 1997-07-25 1999-02-04 Affymetrix, Inc. Method and apparatus for providing a bioinformatics database
US7068830B2 (en) * 1997-07-25 2006-06-27 Affymetrix, Inc. Method and system for providing a probe array chip design database
US6710036B2 (en) 1997-07-25 2004-03-23 Avigen, Inc. Induction of immune response to antigens expressed by recombinant adeno-associated virus
DE69838584T2 (de) 1997-08-04 2008-06-26 Cell Genesys, Inc., Foster City Enhancer des menschlichen glandulären kallikreingens, vektoren die ihn enthalten und methoden für seine verwendung
US5827695A (en) * 1997-08-04 1998-10-27 Novartis Finance Corporation Detection of wheat fungal pathogens using the polymerase chain reaction
CA2298019A1 (en) * 1997-08-05 1999-02-18 Transgenomic, Inc. Denaturing multi ion polynucleotide chromatography for detecting mutations
US7056703B2 (en) 1997-08-06 2006-06-06 Diversa Corporation Polypeptides having polymerase activity and methods of use thereof
US7049101B1 (en) * 1997-08-06 2006-05-23 Diversa Corporation Enzymes having high temperature polymerase activity and methods of use thereof
US6120995A (en) * 1997-08-07 2000-09-19 Thomas Jefferson University Compositions that specifically bind to colorectal cancer cells and methods of using the same
US7135333B1 (en) 1997-08-07 2006-11-14 Thomas Jefferson University Compositions that specifically bind to colorectal cancer cells and methods of using the same
DE1002138T1 (de) 1997-08-08 2001-06-07 Akzo Nobel Nv Nukleinsäuresequenzen als primer und sonden zur amplifizierung und erkennung von allen hiv-1 subtypen
US20090269814A1 (en) * 1998-05-22 2009-10-29 Murphy Patricia D Method of Analyzing a BRCA2 Gene in a Human Subject
EP1009753B1 (en) * 1997-08-21 2005-04-20 Quark Biotech, Inc. Hypoxia-regulated genes
US7973156B2 (en) 1997-08-21 2011-07-05 Quark Pharmaceuticals Inc. Hypoxia-regulated genes
US20030104973A1 (en) * 1997-08-21 2003-06-05 Quark Biotech, Inc. Hypoxia-regulated genes
US5916776A (en) * 1997-08-27 1999-06-29 Sarnoff Corporation Amplification method for a polynucleotide
US6030619A (en) 1997-08-27 2000-02-29 Chiron Corporation Molecular mimetics of meningococcal B epitopes
US5965410A (en) * 1997-09-02 1999-10-12 Caliper Technologies Corp. Electrical current for controlling fluid parameters in microchannels
US6238905B1 (en) 1997-09-12 2001-05-29 University Technology Corporation Thermophilic polymerase III holoenzyme
US6013486A (en) * 1997-09-17 2000-01-11 Yale University Method for selection of insertion mutants
WO1999014375A2 (en) * 1997-09-19 1999-03-25 Genetrace Systems, Inc. Dna typing by mass spectrometry with polymorphic dna repeat markers
US6764822B1 (en) 1997-09-19 2004-07-20 Sequenom, Inc. DNA typing by mass spectrometry with polymorphic DNA repeat markers
US6492109B1 (en) 1997-09-23 2002-12-10 Gene Logic, Inc. Susceptibility mutation 6495delGC of BRCA2
ES2245042T3 (es) 1997-09-24 2005-12-16 The Regents Of The University Of California Vectores de lentivirus de no primates y sistemas de empaquetamiento.
US6355415B1 (en) 1997-09-29 2002-03-12 Ohio University Compositions and methods for the use of ribozymes to determine gene function
DE19743518A1 (de) * 1997-10-01 1999-04-15 Roche Diagnostics Gmbh Automatisierbare universell anwendbare Probenvorbereitungsmethode
US7378244B2 (en) * 1997-10-01 2008-05-27 Geron Corporation Telomerase promoters sequences for screening telomerase modulators
US6344554B1 (en) 1997-10-02 2002-02-05 Regents Of The University Of California Polynucleotide sequences from Candida albicans encoding polypeptides associated with filamentous growth
US6284496B1 (en) 1997-10-03 2001-09-04 University Of South Florida DNA vector for determining the presence of out-of-reading-frame mutations
US6103468A (en) * 1997-10-07 2000-08-15 Labatt Brewing Company Limited Rapid two-stage polymerase chain reaction method for detection of lactic acid bacteria in beer
WO1999019517A1 (en) 1997-10-14 1999-04-22 Transgenomic, Inc. Analysis of nicked dna by matched ion polynucleotide chromatography
US6573094B1 (en) 1997-10-16 2003-06-03 Baylor College Of Medicine F-box genes and proteins
US6051385A (en) * 1997-10-22 2000-04-18 The Regents Of The University Of Michigan Compositions and methods for identifying and testing therapeutics against HSV infection
US6875606B1 (en) 1997-10-23 2005-04-05 The United States Of America As Represented By The Department Of Veterans Affairs Human α-7 nicotinic receptor promoter
NZ504214A (en) * 1997-10-24 2003-06-30 Invitrogen Corp Recombination cloning using nucleic acids having recombination sites
US7351578B2 (en) * 1999-12-10 2008-04-01 Invitrogen Corp. Use of multiple recombination sites with unique specificity in recombinational cloning
CN1163597C (zh) 1997-10-30 2004-08-25 诺维信公司 α-淀粉酶突变体
US6395470B2 (en) * 1997-10-31 2002-05-28 Cenetron Diagnostics, Llc Method for monitoring nucleic acid assays using synthetic internal controls with reversed nucleotide sequences
EP1042503A4 (en) * 1997-10-31 2002-01-16 Transgenomic Inc METHOD FOR DETECTING MUTANT DNA BY MIPC AND PCR
JP2002509694A (ja) 1997-11-04 2002-04-02 ロシュ ダイアグノスティックス ゲーエムベーハー 特異的かつ高感度な核酸検出方法
DE69841807D1 (de) 1997-11-06 2010-09-16 Novartis Vaccines & Diagnostic Neisseriale antigene
US6294326B1 (en) 1997-11-07 2001-09-25 Abbott Laboratories Analyte detection process using dual labeled probes
US6197502B1 (en) 1997-11-17 2001-03-06 Cytos Biotechnology Ag Expression cloning processes for the discovery characterization, and isolation of genes encoding polypeptides with a predetermined property
DE29720432U1 (de) * 1997-11-19 1999-03-25 Mwg Biotech Gmbh Roboter
US6060310A (en) * 1997-11-24 2000-05-09 The United States Of America As Represented By The Department Of Health And Human Services Transcription factor decoy and tumor growth inhibitor
US6117643A (en) * 1997-11-25 2000-09-12 Ut Battelle, Llc Bioluminescent bioreporter integrated circuit
US6174675B1 (en) 1997-11-25 2001-01-16 Caliper Technologies Corp. Electrical current for controlling fluid parameters in microchannels
US8182991B1 (en) 1997-11-26 2012-05-22 Third Wave Technologies, Inc. FEN-1 endonucleases, mixtures and cleavage methods
US6258264B1 (en) 1998-04-10 2001-07-10 Transgenomic, Inc. Non-polar media for polynucleotide separations
US6372130B1 (en) 1997-12-05 2002-04-16 Transgenomic, Inc. Non-polar media for polynucleotide separations
US6503397B2 (en) * 1997-12-05 2003-01-07 Transgenomic, Inc. Non-polar media for polynucleotide separations
CA2313380C (en) * 1997-12-08 2008-12-30 California Institute Of Technology Method for creating polynucleotide and polypeptide sequences
US6046316A (en) 1997-12-09 2000-04-04 Wayne State University Nucleic acid encoding truncated integrins
CN100340666C (zh) 1997-12-18 2007-10-03 孟山都技术有限公司 抗昆虫的转基因植物以及用于改善δ－内毒素抵抗目标昆虫活性的方法
DK1041890T3 (da) 1997-12-22 2005-07-18 Novozymes As Carbohydrat-oxydase og anvendelse deraf til bagning
EP1141281A2 (en) 1997-12-23 2001-10-10 THE UNITED STATES GOVERNMENT as represented by THE DEPARTMENT OF HEALTH AND HUMAN SERVICES The protein tyrosine kinase substrate lat and its uses in the identification of (ant)agonists of the kinase
US20020177144A1 (en) * 1997-12-30 2002-11-28 Jose Remacle Detection and/or quantification method of a target molecule by a binding with a capture molecule fixed on the surface of a disc
US6149867A (en) 1997-12-31 2000-11-21 Xy, Inc. Sheath fluids and collection systems for sex-specific cytometer sorting of sperm
US7687057B2 (en) 1998-01-09 2010-03-30 Yissum Research Development Company Of The Hebrew University Of Jerusalem In vitro micro-organs, and uses related thereto
US6893877B2 (en) 1998-01-12 2005-05-17 Massachusetts Institute Of Technology Methods for screening substances in a microwell array
US6780609B1 (en) 1998-10-23 2004-08-24 Genome Therapeutics Corporation High bone mass gene of 1.1q13.3
DK1047784T4 (en) 1998-01-14 2015-06-15 Novartis Vaccines & Diagnostic NEISSERA meningitidis ANTIGENS
US6426185B1 (en) 1998-01-16 2002-07-30 Large Scale Biology Corporation Method of compiling a functional gene profile in a plant by transfecting a nucleic acid sequence of a donor plant into a different host plant in an anti-sense orientation
US6303848B1 (en) 1998-01-16 2001-10-16 Large Scale Biology Corporation Method for conferring herbicide, pest, or disease resistance in plant hosts
US20030166169A1 (en) * 1998-01-16 2003-09-04 Padgett Hal S. Method for constructing viral nucleic acids in a cell-free manner
US20030027173A1 (en) * 1998-01-16 2003-02-06 Della-Cioppa Guy Method of determining the function of nucleotide sequences and the proteins they encode by transfecting the same into a host
US20020164585A1 (en) * 1998-01-16 2002-11-07 Sean Chapman Method for enhancing RNA or protein production using non-native 5' untranslated sequences in recombinant viral nucleic acids
US6214581B1 (en) 1998-01-16 2001-04-10 Abbott Laboratories Nucleic acids encoding a functional human purinoreceptor P2X3 and P2X6, and methods of production and use thereof
US6764830B1 (en) 1998-01-23 2004-07-20 The Regents Of The University Of California Thermomyces lanuginosus kinesin motor protein and methods of screening for modulators of kinesin proteins
US6686150B1 (en) 1998-01-27 2004-02-03 Clinical Micro Sensors, Inc. Amplification of nucleic acids with electronic detection
AU764926B2 (en) 1998-01-27 2003-09-04 Clinical Micro Sensors, Inc. Amplification of nucleic acids with electronic detection
US20010055809A1 (en) 1998-01-30 2001-12-27 Harpal S. Mangat Extending tissue preservation
CA2319710A1 (en) 1998-01-30 1999-08-05 Jim A. Wright Oligonucleotide sequences complementary to thioredoxin or thioredoxin reductase genes and methods of using same to modulate cell growth
US6287776B1 (en) 1998-02-02 2001-09-11 Signature Bioscience, Inc. Method for detecting and classifying nucleic acid hybridization
EP1058688A4 (en) 1998-02-03 2004-10-06 Xy Inc USE OF SPECIFIC OLIGONUCLEOTIDE PRIMERS TO DETECT THE PRESENCE OF MALE BOVINE CHROMOSOME BY CHAIN AMPLIFICATION BY POLYMERASE
US6238863B1 (en) 1998-02-04 2001-05-29 Promega Corporation Materials and methods for indentifying and analyzing intermediate tandem repeat DNA markers
DE19804372A1 (de) 1998-02-04 1999-08-05 Michael W Dr Dr Dahm Verfahren zur quantitativen Bestimmung von Tumorzellen in einer Körperflüssigkeit und dazu geeignete Testkits
WO1999040208A1 (en) * 1998-02-05 1999-08-12 The General Hospital Corporation In vivo construction of dna libraries
US6420143B1 (en) 1998-02-13 2002-07-16 Caliper Technologies Corp. Methods and systems for performing superheated reactions in microscale fluidic systems
US5962296A (en) * 1998-02-24 1999-10-05 New England Biolabs, Inc. Method for cloning and producing Thermomicrobium roseum DNA polymerase I in E. coli
EP1060191B1 (en) 1998-02-27 2010-04-28 Novo Nordisk A/S Derivatives of glp-1 analogs
EP1062240B1 (en) 1998-02-27 2010-04-28 Novo Nordisk A/S N-terminally modified glp-1 derivatives
CA2759907A1 (en) 1998-02-27 1999-09-02 Novozymes A/S Maltogenic alpha-amylase variants
EP1840134B1 (en) 1998-02-27 2016-04-13 Novo Nordisk A/S GLP-1 derivatives
US5912129A (en) * 1998-03-05 1999-06-15 Vinayagamoorthy; Thuraiayah Multi-zone polymerase/ligase chain reaction
ATE414169T1 (de) * 1998-03-05 2008-11-15 Johnson & Johnson Res Pty Ltd Methoden zur detektion von nukleinsäuren unter verwendung von zymogenen und dazugehörige kits
WO1999046598A1 (en) 1998-03-10 1999-09-16 The Regents Of The University Of California Methods and tools for identifying compounds which modulate atherosclerosis by impacting ldl-proteoglycan binding
US20040058873A1 (en) * 1998-03-12 2004-03-25 Esmond Robert W. Method for treating or preventing Alzheimer's disease
US6235480B1 (en) 1998-03-13 2001-05-22 Promega Corporation Detection of nucleic acid hybrids
US6312902B1 (en) 1998-03-13 2001-11-06 Promega Corporation Nucleic acid detection
US6270974B1 (en) 1998-03-13 2001-08-07 Promega Corporation Exogenous nucleic acid detection
US6268146B1 (en) 1998-03-13 2001-07-31 Promega Corporation Analytical methods and materials for nucleic acid detection
US7090975B2 (en) 1998-03-13 2006-08-15 Promega Corporation Pyrophosphorolysis and incorporation of nucleotide method for nucleic acid detection
US6270973B1 (en) 1998-03-13 2001-08-07 Promega Corporation Multiplex method for nucleic acid detection
US6787305B1 (en) 1998-03-13 2004-09-07 Invitrogen Corporation Compositions and methods for enhanced synthesis of nucleic acid molecules
US6391551B1 (en) 1998-03-13 2002-05-21 Promega Corporation Detection of nucleic acid hybrids
US6277578B1 (en) 1998-03-13 2001-08-21 Promega Corporation Deploymerization method for nucleic acid detection of an amplified nucleic acid target
US6071737A (en) * 1998-03-16 2000-06-06 The Regents Of The University Of California Equine Neospora isolate and its uses
US20040176572A1 (en) * 1998-03-16 2004-09-09 Freimer Nelson B. Methods of compositions for diagnosing and treating chromosome-18p related disorders
WO1999047535A1 (en) 1998-03-16 1999-09-23 Millennium Pharmaceuticals, Inc. METHODS AND COMPOSITIONS FOR DIAGNOSING AND TREATING CHROMOSOME-18p RELATED DISORDERS
US6686513B1 (en) 1998-03-19 2004-02-03 The United States Of America As Represented By The Secretary Of Agriculture Sugarcane ubi9 gene promoter sequence and methods of use thereof
US6706948B1 (en) 1998-03-19 2004-03-16 The United States Of America As Represented By The Secretary Of Agriculture Sugarcane UBI9 gene promoter and methods of use thereof
CA2323812C (en) 1998-03-20 2011-05-10 The Curators Of The University Of Missouri Early pregnancy diagnosis using pags (pregnancy-associated glycoproteins)
US6436707B1 (en) * 1998-03-27 2002-08-20 Lexicon Genetics Incorporated Vectors for gene mutagenesis and gene discovery
US6500637B1 (en) * 1998-03-31 2002-12-31 The Institute Of Physical And Chemical Research Neurogenesis inducing genes
JPH11341989A (ja) 1998-03-31 1999-12-14 Sanyo Electric Co Ltd Ｄｎａ断片増幅方法、ｄｎａ断片増幅装置、微生物群測定方法、微生物群分析方法および汚染物質測定方法
US6337200B1 (en) * 1998-03-31 2002-01-08 Geron Corporation Human telomerase catalytic subunit variants
US6022952A (en) * 1998-04-01 2000-02-08 University Of Alberta Compositions and methods for protein secretion
US6949367B1 (en) 1998-04-03 2005-09-27 Epoch Pharmaceuticals, Inc. Modified oligonucleotides for mismatch discrimination
US7715989B2 (en) * 1998-04-03 2010-05-11 Elitech Holding B.V. Systems and methods for predicting oligonucleotide melting temperature (TmS)
US6683173B2 (en) * 1998-04-03 2004-01-27 Epoch Biosciences, Inc. Tm leveling methods
US7045610B2 (en) * 1998-04-03 2006-05-16 Epoch Biosciences, Inc. Modified oligonucleotides for mismatch discrimination
US6127121A (en) * 1998-04-03 2000-10-03 Epoch Pharmaceuticals, Inc. Oligonucleotides containing pyrazolo[3,4-D]pyrimidines for hybridization and mismatch discrimination
ATE419013T1 (de) 1998-04-15 2009-01-15 Hutchinson Fred Cancer Res Methoden und vektorenkonstrukte zur erzeugung von transgene nagetieren, welche ein heterologes gen ubiquitär exprimieren
US6733967B1 (en) 1998-04-21 2004-05-11 Interleukin Genetics, Inc. Fetal testing for prediction of low birth weight
EP2267127A1 (en) 1998-04-28 2010-12-29 Ortho-Clinical Diagnostics, Inc. Improved methods for extracting nucleic acids from tissue samples and paraffin-embedded tissues
US6068974A (en) * 1998-04-29 2000-05-30 Klann; Richard Chris Specific, highly sensitive, nested PCR detection scheme for the pseudorabies virus
US7875440B2 (en) 1998-05-01 2011-01-25 Arizona Board Of Regents Method of determining the nucleotide sequence of oligonucleotides and DNA molecules
US8337753B2 (en) 1998-05-01 2012-12-25 Gen-Probe Incorporated Temperature-controlled incubator having a receptacle mixing mechanism
EP2261351A3 (en) 1998-05-01 2012-01-11 Novartis Vaccines and Diagnostics, Inc. Neisseria meningitidis antigens and compositions
DE10011529T1 (de) 1998-05-01 2011-09-01 Gen-Probe Incorporated Automatisches Diagnoseanalysegerät und Verfahren
US6232065B1 (en) 1998-05-06 2001-05-15 Case Western Reserve University Analysis of gene family expression
US6686163B2 (en) 1998-05-06 2004-02-03 Gene Logic Inc. Coding sequence haplotype of the human BRCA1 gene
US20080206206A1 (en) 1998-05-07 2008-08-28 University Of South Florida Bone marrow-derived neuronal cells
US6225456B1 (en) 1998-05-07 2001-05-01 University Technololy Corporation Ras suppressor SUR-5
US6391544B1 (en) 1998-05-15 2002-05-21 Abbott Laboratories Method for using unequal primer concentrations for generating nucleic acid amplification products
US7498164B2 (en) 1998-05-16 2009-03-03 Applied Biosystems, Llc Instrument for monitoring nucleic acid sequence amplification reaction
US6818437B1 (en) * 1998-05-16 2004-11-16 Applera Corporation Instrument for monitoring polymerase chain reaction of DNA
WO1999060381A1 (en) 1998-05-16 1999-11-25 The Perkin-Elmer Corporation Instrument for monitoring polymerase chain reaction of dna
US6468743B1 (en) 1998-05-18 2002-10-22 Conagra Grocery Products Company PCR techniques for detecting microbial contaminants in foodstuffs
US6485648B1 (en) 1998-05-18 2002-11-26 Transgenomic, Inc. MIPC column cleaning system and process
US6506889B1 (en) 1998-05-19 2003-01-14 University Technology Corporation Ras suppressor SUR-8 and related compositions and methods
US6225063B1 (en) 1998-05-22 2001-05-01 University Technology Corporation RNA channels in biological membranes
DE19824900B4 (de) * 1998-06-04 2006-05-04 Roche Diagnostics Gmbh DNA-Nachweis über einen Strangreassoziationskomplex
AU755850B2 (en) 1998-06-10 2002-12-19 Novozymes A/S Novel mannanases
US6489095B2 (en) * 1998-06-15 2002-12-03 Mitokor Diagnostic method based on quantification of extramitochondrial DNA
US6441149B1 (en) 1998-06-15 2002-08-27 Mitokor Diagnostic method based on quantification of extramitochondrial DNA
US7153655B2 (en) 1998-06-16 2006-12-26 Alligator Bioscience Ab Method for in vitro molecular evolution of protein function involving the use of exonuclease enzyme and two populations of parent polynucleotide sequence
US6214187B1 (en) 1998-06-18 2001-04-10 Mosaic Technologies Denaturing gradient affinity electrophoresis and methods of use thereof
US6365408B1 (en) 1998-06-19 2002-04-02 Maxygen, Inc. Methods of evolving a polynucleotides by mutagenesis and recombination
WO1999067426A1 (en) * 1998-06-23 1999-12-29 Board Of Regents, The University Of Texas System Absorptive hypercalciuria locus on human chromosome 1
US20050244954A1 (en) * 1998-06-23 2005-11-03 Blackburn Gary F Binding acceleration techniques for the detection of analytes
US8445664B2 (en) * 1998-06-24 2013-05-21 Enzo Diagnostics, Inc. Kits for amplifying and detecting nucleic acid sequences
US6242235B1 (en) 1998-06-24 2001-06-05 Promega Corp. Polymerase stabilization by polyethoxylated amine surfactants
US6835867B1 (en) 1998-06-24 2004-12-28 Richard P. Woychik Allelic series of genomic modifications in cells
US20040229363A1 (en) * 1998-06-24 2004-11-18 Ed Nolan High efficiency transfection based on low electric field strength, long pulse length
US6743605B1 (en) * 1998-06-24 2004-06-01 Enzo Life Sciences, Inc. Linear amplification of specific nucleic acid sequences
US6344443B1 (en) 1998-07-08 2002-02-05 University Of South Florida Peptide antagonists of tumor necrosis factor alpha
US7052696B2 (en) 1998-07-10 2006-05-30 The United States Of America As Represented By The Department Of Health And Human Services Antigenic epitopes and mosaic polypeptides of hepatitis C virus proteins
US6908770B1 (en) 1998-07-16 2005-06-21 Board Of Regents, The University Of Texas System Fluid based analysis of multiple analytes by a sensor array
US6316229B1 (en) 1998-07-20 2001-11-13 Yale University Single molecule analysis target-mediated ligation of bipartite primers
US6277337B1 (en) 1998-07-21 2001-08-21 Gambro, Inc. Method and apparatus for inactivation of biological contaminants using photosensitizers
US7498156B2 (en) 1998-07-21 2009-03-03 Caridianbct Biotechnologies, Llc Use of visible light at wavelengths of 500 to 550 nm to reduce the number of pathogens in blood and blood components
US7049110B2 (en) 1998-07-21 2006-05-23 Gambro, Inc. Inactivation of West Nile virus and malaria using photosensitizers
US6258577B1 (en) 1998-07-21 2001-07-10 Gambro, Inc. Method and apparatus for inactivation of biological contaminants using endogenous alloxazine or isoalloxazine photosensitizers
WO2000005396A1 (en) * 1998-07-21 2000-02-03 Danisco A/S Foodstuff
US7700353B2 (en) * 1998-07-22 2010-04-20 E-P Therapeutics, Inc. Compositions and methods for inducing apoptosis in tumor cells
EP1806362B1 (en) 1998-07-28 2010-07-21 The Regents of the University of California Nucleic acids encoding a G-protein coupled receptor involved in sensory transduction
US7402400B2 (en) 2001-07-03 2008-07-22 Regents Of The University Of California Mammalian sweet taste receptors
NZ509434A (en) 1998-07-30 2004-03-26 Univ Colorado State Res Found Equine system for non-surgical artificial insemination
AU5329599A (en) * 1998-07-30 2000-02-21 University Of South Florida Method for the modulation of function of transcription factors
JP2002521070A (ja) * 1998-07-31 2002-07-16 ジェン−プローブ・インコーポレーテッド 可逆的阻害プローブ
US6699986B2 (en) 1998-08-04 2004-03-02 Ortho-Clinical Diagnostics, Inc. Electrophoretic separation of nucleic acids from proteins at low ph
US6455692B1 (en) 1998-08-04 2002-09-24 Transgenomic, Inc. Method of concentrating polynucleotides using MIPC
US20070161010A1 (en) * 1998-08-04 2007-07-12 Gjerde Douglas T Methods and compositions for mutation analysis
RU2290439C2 (ru) 1998-08-06 2006-12-27 Дьюк Юниверсити Рекомбинантный белок уриказы млекопитающего для конъюгирования с пэг, молекула нуклеиновой кислоты, кодирующая его, вектор для его экспрессии, способ его получения и применение
DK2272859T3 (en) 1998-08-07 2015-01-19 Univ Washington Immunological herpes simplex virus antigens and methods for their use
WO2000010579A1 (en) 1998-08-18 2000-03-02 California Skin Research Institute Method for detection of biological factors in epidermis
CZ2001584A3 (cs) 1998-08-18 2002-06-12 The Regents Of The University Of California Prevence tvorby hlenu v dýchacích cestách podáváním antagonistů EGF-R
CZ301915B6 (cs) 1998-08-19 2010-07-28 Monsanto Technology Llc Rekombinantní molekula DNA, transformovaná bunka, rostlina a zpusob zlepšení genové exprese
US6180408B1 (en) 1998-08-21 2001-01-30 Washington University Fluorescence polarization in nucleic acid analysis
US6207379B1 (en) 1998-09-11 2001-03-27 One Lambda Method for amplification of DNA
US7029861B1 (en) 1998-09-15 2006-04-18 Board Of Regents, The University Of Texas System LPS-response gene compositions and methods
AU763890B2 (en) 1998-09-15 2003-07-31 Yale University Artificial long terminal repeat vectors
US6287824B1 (en) 1998-09-15 2001-09-11 Yale University Molecular cloning using rolling circle amplification
US6185561B1 (en) 1998-09-17 2001-02-06 Affymetrix, Inc. Method and apparatus for providing and expression data mining database
US20040199544A1 (en) * 2000-11-02 2004-10-07 Affymetrix, Inc. Method and apparatus for providing an expression data mining database
EP1114188A2 (en) 1998-09-18 2001-07-11 University of Nebraska-Lincoln High resolution genome scanning
EA201001190A1 (ru) 1998-09-23 2011-04-29 Займодженетикс, Инк. Выделенное антитело, специфически связанное с полипептидом, состоящее из последовательности аминокислотных остатков
US6703228B1 (en) * 1998-09-25 2004-03-09 Massachusetts Institute Of Technology Methods and products related to genotyping and DNA analysis
EP1117762A4 (en) 1998-09-29 2004-02-25 Gamida Cell Ltd METHOD FOR CONTROLLING PROLIFERATION AND DIFFERENTIATION OF STEM CELLS AND PRECELLER CELLS
US6197510B1 (en) 1998-10-01 2001-03-06 Bio-Id Diagnostic Inc. Multi-loci genomic analysis
US6743906B1 (en) 1998-10-02 2004-06-01 Board Of Regents, The University Of Texas PPP2R1B is a tumor suppressor
WO2000021358A1 (en) 1998-10-14 2000-04-20 Agriculture And Agri-Food Canada Hybrid alfalfa (medicago sativa)
US6413780B1 (en) * 1998-10-14 2002-07-02 Abbott Laboratories Structure and method for performing a determination of an item of interest in a sample
US6489096B1 (en) 1998-10-15 2002-12-03 Princeton University Quantitative analysis of hybridization patterns and intensities in oligonucleotide arrays
GB9822777D0 (en) 1998-10-20 1998-12-16 Tepnel Medical Ltd Template chain reaction
ATE290012T1 (de) * 1998-10-21 2005-03-15 Univ Kansas Ct For Res Inc Methode für die herstellung von gereinigtem invasinprotein und seine anwendung
US6667176B1 (en) 2000-01-11 2003-12-23 Geron Corporation cDNA libraries reflecting gene expression during growth and differentiation of human pluripotent stem cells
AU2144000A (en) 1998-10-27 2000-05-15 Affymetrix, Inc. Complexity management and analysis of genomic dna
US6348643B1 (en) 1998-10-29 2002-02-19 American Cyanamid Company DNA sequences encoding the arabidopsis acetohydroxy-acid synthase small subunit and methods of use
US6949370B1 (en) 1998-10-30 2005-09-27 Cornell Research Foundation, Inc. High fidelity thermostable ligase and uses thereof
US6153411A (en) 1998-10-30 2000-11-28 American Water Works Company, Inc. Methods and kits for detection of Cryptosporidium parvum using immunomagnetic separation and amplification
US6545264B1 (en) 1998-10-30 2003-04-08 Affymetrix, Inc. Systems and methods for high performance scanning
US20060205034A1 (en) * 1998-10-30 2006-09-14 Millennium Pharmaceuticals, Inc. Novel genes encoding proteins having prognostic, diagnostic, preventive, therapeutic, and other uses
US6313373B1 (en) 1998-10-30 2001-11-06 Case Western Reserve University Tissue specific promoters and transgenic mouse for the screening of pharmaceuticals
US20030027998A1 (en) * 1998-10-30 2003-02-06 Holtzman Douglas A. Novel genes encoding proteins having prognostic, diagnostic, preventive, therapeutic, and other uses
US6489542B1 (en) 1998-11-04 2002-12-03 Monsanto Technology Llc Methods for transforming plants to express Cry2Ab δ-endotoxins targeted to the plastids
ES2320814T3 (es) 1998-11-09 2009-05-28 Eiken Kagaku Kabushiki Kaisha Procedimiento de sintesis de acido nucleico.
WO2000028018A1 (en) 1998-11-10 2000-05-18 Maxygen, Inc. Modified adp-glucose pyrophosphorylase for improvement and optimization of plant phenotypes
AU772847B2 (en) 1998-11-12 2004-05-06 Invitrogen Corporation Transfection reagents
WO2000029008A2 (en) 1998-11-16 2000-05-25 Board Of Regents, The University Of Texas System Hiv-specific t-cell induction
DK1135511T3 (da) 1998-11-17 2009-07-27 Monsanto Technology Llc Phosphonatmetaboliserende planter
US6191154B1 (en) 1998-11-27 2001-02-20 Case Western Reserve University Compositions and methods for the treatment of Alzheimer's disease, central nervous system injury, and inflammatory diseases
DE19854946C2 (de) 1998-11-27 2002-01-03 Guenter Von Kiedrowski Klonieren und Kopieren an Oberflächen
JP4723087B2 (ja) 1998-11-27 2011-07-13 ノボザイムス アクティーゼルスカブ 脂質分解酵素変異体
CA2255850C (en) 1998-12-07 2000-10-17 Her Majesty The Queen In Right Of Canada As Represented By The Minister Of Agriculture And Agri-Food Rotary thermocycling apparatus
DK1137773T3 (da) 1998-12-07 2008-12-08 Zymogenetics Inc Væsktfaktorhomolog ZVEGF3
US6242666B1 (en) 1998-12-16 2001-06-05 The Scripps Research Institute Animal model for identifying a common stem/progenitor to liver cells and pancreatic cells
EE05627B1 (et) * 1998-12-23 2013-02-15 Pfizer Inc. CTLA-4 vastased inimese monoklonaalsed antikehad
US7109003B2 (en) 1998-12-23 2006-09-19 Abgenix, Inc. Methods for expressing and recovering human monoclonal antibodies to CTLA-4
KR100849443B1 (ko) 1998-12-23 2008-07-31 화이자 인크. Ｃｔｌａ－４에 대한 인간 단일클론 항체
US20030180789A1 (en) * 1998-12-30 2003-09-25 Dale Roderic M.K. Arrays with modified oligonucleotide and polynucleotide compositions
US6441156B1 (en) * 1998-12-30 2002-08-27 The United States Of America As Represented By The Department Of Health And Human Services Calcium channel compositions and methods of use thereof
US6087112A (en) * 1998-12-30 2000-07-11 Oligos Etc. Inc. Arrays with modified oligonucleotide and polynucleotide compositions
AU2221600A (en) 1998-12-31 2000-07-31 Chiron Corporation Improved expression of hiv polypeptides and production of virus-like particles
US7935805B1 (en) 1998-12-31 2011-05-03 Novartis Vaccines & Diagnostics, Inc Polynucleotides encoding antigenic HIV Type C polypeptides, polypeptides and uses thereof
US20010034438A1 (en) * 2000-01-12 2001-10-25 Walke D. Wade Novel human membrane protein and polynucleotides encoding the same
US20020031802A1 (en) * 2000-05-12 2002-03-14 Yi Hu Novel seven transmembrane proteins and polynucleotides encoding the same
US20040005673A1 (en) * 2001-06-29 2004-01-08 Kevin Jarrell System for manipulating nucleic acids
EP1141275B1 (en) * 1999-01-05 2009-08-12 Trustees Of Boston University Improved nucleic acid cloning
EP1108781A3 (en) 1999-01-19 2001-09-12 Maxygen, Inc. Method for making character strings, polynucleotides and polypeptides
AU777909B2 (en) 1999-01-19 2004-11-04 Lexicon Genetics Incorporated Mammalian cortexin-like proteins and polynucleotides encoding the same
US20040235107A1 (en) * 1999-01-29 2004-11-25 Ramot At Tel Aviv University Ltd. Biosynthesis of TA antibiotic
KR100294374B1 (ko) * 1999-01-30 2001-07-03 김재종 Ｄｎａ 함유 잉크 및 그의 제조방법
US6355271B1 (en) * 1999-02-03 2002-03-12 Biosante Pharmaceuticals, Inc. Therapeutic calcium phosphate particles and methods of manufacture and use
MXPA01007820A (es) 1999-02-04 2003-06-19 Technion Res & Dev Foundation Metodo y aparato para mantenimiento y expansion de celulas de tallo hemopoyeticas y/o celulas progenitoras.
US20090130718A1 (en) * 1999-02-04 2009-05-21 Diversa Corporation Gene site saturation mutagenesis
US6605432B1 (en) 1999-02-05 2003-08-12 Curators Of The University Of Missouri High-throughput methods for detecting DNA methylation
US6395472B1 (en) 1999-02-05 2002-05-28 Abbott Laboratories Methods of utilizing the TT virus
US7135284B1 (en) 1999-02-05 2006-11-14 Integrated Dna Technologies, Inc. Primer extension methods for production of high specific activity nucleic acid probes
EP1153037A1 (en) * 1999-02-09 2001-11-14 Lexicon Genetics Incorporated Human uncoupling proteins and polynucleotides encoding the same
US6156515A (en) * 1999-02-09 2000-12-05 Urocor, Inc. Prostate-specific gene for diagnosis, prognosis and management of prostate cancer
ES2353728T3 (es) 1999-02-10 2011-03-04 Curis, Inc. Péptido yy (pyy) para tratar trastornos metabólicos de la glucosa.
US7745216B2 (en) * 1999-02-10 2010-06-29 Curis, Inc. Methods and reagents for treating glucose metabolic disorders
KR20010102069A (ko) 1999-02-11 2001-11-15 추후제출 고효율 질량 분석
JP5007003B2 (ja) 1999-02-12 2012-08-22 ステムセルズ・カリフォルニア・インコーポレイテッド 富化された中枢神経系の幹細胞および始原細胞の集団、ならびにこのような集団を同定、単離、および富化するための方法
US20030068635A1 (en) * 1999-02-16 2003-04-10 Boehringer Mannheim Gmbh Determination of an analyte using two labels
US6153389A (en) * 1999-02-22 2000-11-28 Haarer; Brian K. DNA additives as a mechanism for unambiguously marking biological samples
AU3382800A (en) 1999-02-26 2000-09-14 Millennium Pharmaceuticals, Inc. Secreted proteins and uses thereof
US6221595B1 (en) 1999-03-01 2001-04-24 Syngenta Participations Ag Detection of Monilinia spp. using the polymerase chain reaction
US6187566B1 (en) 1999-03-09 2001-02-13 Applied Gene Technologies, Inc. Method of labeling a nucleic acid amplicon with simultaneous contamination prevention
CN101575377B (zh) 1999-03-09 2012-12-26 津莫吉尼蒂克斯公司 作为zalpha受体之配体的人细胞因子及其用途
DE60042883D1 (de) * 1999-03-11 2009-10-15 Arborgen Llc Zusammensetzungen und verfahren zur veränderung der gentranskription
US20040259145A1 (en) * 1999-03-11 2004-12-23 Marion Wood Compositions and methods for the modification of gene expression
US20110047644A1 (en) * 1999-03-11 2011-02-24 Marion Wood Compositions and methods for the modification of gene transcription
US6440715B1 (en) 1999-03-12 2002-08-27 New England Biolabs, Inc. Method for cloning and expression of Rhodothermus Obamensis DNA polymerase I large fragment in E. coli
CA2365263A1 (en) * 1999-03-12 2000-09-21 Mcgill University A method for increasing the processivity of a dna- or rna-dependent polymerase and compositions therefor
US6451987B1 (en) 1999-03-15 2002-09-17 Novo Nordisk A/S Ion exchange chromatography of proteins and peptides
CA2367906A1 (en) * 1999-03-15 2000-09-21 Thomas Jefferson University Tcl-1b gene and protein and related methods and compositions
WO2000055203A1 (en) 1999-03-15 2000-09-21 Novo Nordisk A/S Ion exchange chromatographic separation of glp-1 and related peptides
EP1165771A2 (en) * 1999-03-17 2002-01-02 The University Of Tennessee Research Corporation Rt-pcr of clonal neurospheres
KR20020007331A (ko) 1999-03-18 2002-01-26 추후제출 특이 ｌｎａ 프라이머에 의한 유전자중의 돌연변이 검출
NZ513390A (en) 1999-03-19 2003-01-31 Genencor Int Multi-through hole testing plate for high throughput screening
US6506594B1 (en) * 1999-03-19 2003-01-14 Cornell Res Foundation Inc Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays
US7014994B1 (en) 1999-03-19 2006-03-21 Cornell Research Foundation,Inc. Coupled polymerase chain reaction-restriction-endonuclease digestion-ligase detection reaction process
US6630333B1 (en) * 1999-03-23 2003-10-07 Invitrogen Corporation Substantially pure reverse transriptases and methods of production thereof
US6303305B1 (en) 1999-03-30 2001-10-16 Roche Diagnostics, Gmbh Method for quantification of an analyte
BRPI0009362B8 (pt) 1999-03-30 2019-08-20 Novozymes As variante de uma alfa-amilase precursora, e, uso de uma variante de alfa-amilase
JP4745503B2 (ja) 1999-03-31 2011-08-10 ノボザイムス アクティーゼルスカブ アルカリα−アミラーゼ活性を有するポリペプチド及びそれらをコードする核酸
AU3419200A (en) 1999-03-31 2000-10-23 Novozymes A/S Polypeptides having alkaline alpha-amylase activity and nucleic acids encoding same
US6383753B1 (en) 1999-03-31 2002-05-07 Regents Of The University Of Michigan Yeast mammalian regulators of cell proliferation
AU775950B2 (en) * 1999-03-31 2004-08-19 Government of the United States of America, as Represented by the Secretary, Department of Health and Human Services, Centers for Disease Control and Prevention, The Typing of human enteroviruses
AU767983B2 (en) 1999-04-09 2003-11-27 Esoterix Genetic Laboratories, Llc Methods for detecting nucleic acids indicative of cancer
JP2002543767A (ja) * 1999-04-09 2002-12-24 マクギル ユニバーシティー 生殖細胞と体細胞が４ｅ−ｂｐ１をコードするｄｎａにノックアウト突然変異を含有する非ヒトトランスジェニック動物
US6326173B1 (en) * 1999-04-12 2001-12-04 Nanogen/Becton Dickinson Partnership Electronically mediated nucleic acid amplification in NASBA
EP1177423A4 (en) * 1999-04-12 2004-10-27 Nanogen Becton Dickinson Partn REINFORCEMENT AND SEPARATION OF NUCLEIC ACID SEQUENCES BY MEANS OF STRAND SHIFT REINFORCEMENT AND BIOELECTRONIC
US6531302B1 (en) 1999-04-12 2003-03-11 Nanogen/Becton Dickinson Partnership Anchored strand displacement amplification on an electronically addressable microchip
US6309833B1 (en) 1999-04-12 2001-10-30 Nanogen/Becton Dickinson Partnership Multiplex amplification and separation of nucleic acid sequences on a bioelectronic microchip using asymmetric structures
US6238868B1 (en) 1999-04-12 2001-05-29 Nanogen/Becton Dickinson Partnership Multiplex amplification and separation of nucleic acid sequences using ligation-dependant strand displacement amplification and bioelectronic chip technology
US6235479B1 (en) 1999-04-13 2001-05-22 Bio Merieux, Inc. Methods and devices for performing analysis of a nucleic acid sample
EP1196630B2 (en) 1999-04-20 2018-10-17 Illumina, Inc. Detection of nucleic acid reactions on bead arrays
US20060275782A1 (en) 1999-04-20 2006-12-07 Illumina, Inc. Detection of nucleic acid reactions on bead arrays
US20030207295A1 (en) * 1999-04-20 2003-11-06 Kevin Gunderson Detection of nucleic acid reactions on bead arrays
WO2000066780A2 (en) 1999-04-30 2000-11-09 University Of Florida Adeno-associated virus-delivered ribozyme compositions and methods of use
US20020110809A1 (en) * 1999-04-30 2002-08-15 Nehls Michael C. Novel human polynucleotides and polypeptides encoded thereby
EP1181050A4 (en) 1999-04-30 2005-05-18 Jolla Inst Allergy Immunolog METHODS FOR PREVENTING THE REACTIVATION OF LATENT VIRUSES AND CONTROLLING VIRUS REPLICATION
PT1206571E (pt) 1999-05-04 2004-12-31 Ortho Clinical Diagnostics Inc Captura rapida e eficaz de adn a partir duma amostra sem recurso a um reagente de lise celular
US20050169896A1 (en) * 1999-05-14 2005-08-04 Henry Ford Health System Bone marrow transplantation for treatment of stroke
US6310199B1 (en) 1999-05-14 2001-10-30 Promega Corporation pH dependent ion exchange matrix and method of use in the isolation of nucleic acids
US7332326B1 (en) 1999-05-14 2008-02-19 Tecan Trading Ag Centripetally-motivated microfluidics system for performing in vitro hybridization and amplification of nucleic acids
EP1183035B1 (en) * 1999-05-14 2014-12-03 Henry Ford Health System Bone marrow transplantation for treatment of stroke
US8017112B2 (en) * 1999-05-14 2011-09-13 Henry Ford Health System Transplantation of bone marrow stromal cells for treatment of neurodegenerative diseases
US6974684B2 (en) * 2001-08-08 2005-12-13 Curagen Corporation Therapeutic polypeptides, nucleic acids encoding same, and methods of use
US20040229779A1 (en) * 1999-05-14 2004-11-18 Ramesh Kekuda Therapeutic polypeptides, nucleic acids encoding same, and methods of use
US6270970B1 (en) 1999-05-14 2001-08-07 Promega Corporation Mixed-bed solid phase and its use in the isolation of nucleic acids
US7423750B2 (en) * 2001-11-29 2008-09-09 Applera Corporation Configurations, systems, and methods for optical scanning with at least one first relative angular motion and at least one second angular motion or at least one linear motion
US20050279949A1 (en) 1999-05-17 2005-12-22 Applera Corporation Temperature control for light-emitting diode stabilization
US7410793B2 (en) * 1999-05-17 2008-08-12 Applera Corporation Optical instrument including excitation source
US7387891B2 (en) * 1999-05-17 2008-06-17 Applera Corporation Optical instrument including excitation source
ATE421976T1 (de) 1999-05-18 2009-02-15 Dyax Corp Fab fragmentbibliotheken und verfahren für deren verwendung
US20030096321A1 (en) * 1999-05-19 2003-05-22 Jose Remacle Method for the identification and/or the quantification of a target compound obtained from a biological sample upon chips
US8080380B2 (en) * 1999-05-21 2011-12-20 Illumina, Inc. Use of microfluidic systems in the detection of target analytes using microsphere arrays
WO2000071757A1 (en) * 1999-05-21 2000-11-30 Invitrogen Corporation Compositions and methods for labeling of nucleic acid molecules
US6346382B1 (en) 1999-06-01 2002-02-12 Vanderbilt University Human carbamyl phosphate synthetase I polymorphism and diagnostic methods related thereto
US6787318B1 (en) * 1999-06-01 2004-09-07 Roskamp Research Institute, Llc Assay for evaluating the therapeutic effectiveness of agents in reducing Alzheimer's disease pathology
US9486429B2 (en) 1999-06-01 2016-11-08 Vanderbilt University Therapeutic methods employing nitric oxide precursors
US20040067490A1 (en) * 2001-09-07 2004-04-08 Mei Zhong Therapeutic polypeptides, nucleic acids encoding same, and methods of use
US7534605B2 (en) 1999-06-08 2009-05-19 Yissum Research Development Company Of The Hebrew University Of Jerusalem CD44 polypeptides, polynucleotides encoding same, antibodies directed thereagainst and method of using same for diagnosing and treating inflammatory diseases
US6610906B1 (en) 1999-06-09 2003-08-26 The Regents Of The University Of Michigan Nucleotide sequences for gene regulation and methods of use thereof
US6869767B1 (en) 1999-06-11 2005-03-22 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Detection of Streptococcus pneumoniae and immunization against Streptococcus pneumoniae infection
DE60040299D1 (de) 1999-06-14 2008-10-30 Ford Henry Health System Stickstoffmonoxid-donoren zum induzieren von neurogenese
US7655423B2 (en) * 1999-06-14 2010-02-02 Henry Ford Health System Nitric oxide donors for inducing neurogenesis
US7135498B1 (en) 1999-06-14 2006-11-14 Henry Ford Health System Nitric oxide donors for inducing neurogenesis
JP2004529312A (ja) 1999-06-18 2004-09-24 ガメラ バイオサイエンス コーポレイション 小型化均一アッセイ用のデバイスおよび方法
WO2000079009A2 (en) 1999-06-22 2000-12-28 Invitrogen Corporation Improved primers and methods for the detection and discrimination of nucleic acids
US6200781B1 (en) 1999-06-25 2001-03-13 Integrated Genetic Devices, Ltd. Apparatus, system and method for automated execution and analysis of biological and chemical reactions
US6750357B1 (en) 1999-06-25 2004-06-15 Syngen, Inc. Rhodamine-based fluorophores useful as labeling reagents
CA2377541A1 (en) * 1999-06-25 2001-01-04 Eduardo N. Mitrani Method of inducing angiogenesis by micro-organs
US7183405B2 (en) 1999-06-25 2007-02-27 Syn Gen, Inc. Compositions and methods for labeling oligonucleotides
US6818395B1 (en) 1999-06-28 2004-11-16 California Institute Of Technology Methods and apparatus for analyzing polynucleotide sequences
IL147182A0 (en) 1999-06-30 2002-08-14 Interleukin Genetics Inc Diagnostics and therapeutics for diseases associated with an il-1 inflammatory haplorype
US7291714B1 (en) 1999-06-30 2007-11-06 Millennium Pharmaceuticals, Inc. Glycoprotein VI and uses thereof
US6297014B1 (en) 1999-07-02 2001-10-02 Cedars-Sinai Medical Center Genetic test to determine non-responsiveness to statin drug treatment
US6830902B1 (en) 1999-07-02 2004-12-14 Invitrogen Corporation Compositions and methods for enhanced sensitivity and specificity of nucleic acid synthesis
US6455290B1 (en) 1999-07-09 2002-09-24 Pharmacia Italia S.P.A. Tankyrase homolog protein (THP), nucleic acids, and methods related to the same
CA2378552A1 (en) * 1999-07-09 2001-01-18 The Government Of The United States Of America Production of attenuated, human-bovine chimeric respiratory syncytial virus vaccines
CN100510067C (zh) 1999-07-09 2009-07-08 诺维信公司 葡糖淀粉酶变体
MXPA02000490A (es) * 1999-07-13 2004-09-27 Us Gov Health & Human Serv Produccion de virus sincitiales respiratorios recombinantes, que expresan moleculas inmunomoduladoras.
US6533912B2 (en) 1999-07-13 2003-03-18 Molecular Dynamics, Inc. Increased throughput analysis of small compounds using multiple temporally spaced injections
WO2001006253A2 (en) 1999-07-16 2001-01-25 Board Of Regents, The University Of Texas System Detection system based on an analyte reactive particle
US7022517B1 (en) 1999-07-16 2006-04-04 Board Of Regents, The University Of Texas System Method and apparatus for the delivery of samples to a chemical sensor array
US6458536B1 (en) * 1999-07-23 2002-10-01 The Regents Of The University Of California Modified SSCP method using sequential electrophoresis of multiple nucleic acid segments
US7935481B1 (en) 1999-07-26 2011-05-03 Osmetech Technology Inc. Sequence determination of nucleic acids using electronic detection
US6379930B1 (en) 1999-07-30 2002-04-30 Applied Gene Technologies, Inc. Stabilization of nucleic acid amplification cocktails
US6242188B1 (en) 1999-07-30 2001-06-05 Applied Gene Technologies, Inc. Sample processing to release nucleic acids for direct detection
EP1210358A4 (en) * 1999-08-13 2005-01-05 Univ Brandeis PROOF OF NUCLEIC ACIDS
US6232104B1 (en) 1999-08-17 2001-05-15 Dade Behring Inc. Detection of differences in nucleic acids by inhibition of spontaneous DNA branch migration
US6875582B1 (en) 1999-08-19 2005-04-05 Omniscience Pharmaceuticals, Inc. Methods and targets of antibiotic resistance
AT410218B (de) 1999-08-20 2003-03-25 Baxter Ag Verfahren zur herstellung eines qualitätsgesicherten pools biologischer proben
PT1210428E (pt) 1999-08-23 2015-07-21 Genetics Inst Llc Pd-1, um recetor para b7-4 e suas utilizações
US7605238B2 (en) * 1999-08-24 2009-10-20 Medarex, Inc. Human CTLA-4 antibodies and their uses
US7740868B2 (en) 1999-08-25 2010-06-22 Allergan, Inc. Activatable clostridial toxins
US20080032931A1 (en) * 1999-08-25 2008-02-07 Steward Lance E Activatable clostridial toxins
US6599701B1 (en) 1999-08-25 2003-07-29 Clarity Biosciences, Inc. Identifying organisms by detecting intronic nucleic acids
US20090018081A1 (en) * 1999-08-25 2009-01-15 Allergan, Inc. Activatable clostridial toxins
DE60032367T3 (de) * 1999-08-25 2011-03-10 Allergan, Inc., Irvine Aktivierbare rekombinante neurotoxine
US6492118B1 (en) 1999-08-27 2002-12-10 Matrix Technologies Corporation Methods of immobilizing ligands on solid supports
CA2384407C (en) 1999-08-30 2009-10-20 Roche Diagnostics Gmbh 2-azapurine compounds and their use
US6633785B1 (en) 1999-08-31 2003-10-14 Kabushiki Kaisha Toshiba Thermal cycler and DNA amplifier method
EP1214426A2 (en) 1999-08-31 2002-06-19 Novozymes A/S Novel proteases and variants thereof
US6846626B1 (en) * 1999-09-01 2005-01-25 Genome Technologies, Llc Method for amplifying sequences from unknown DNA
US20010034437A1 (en) * 2000-01-06 2001-10-25 Walke D. Wade Novel human proteases and polynucleotides encoding the same
US6716614B1 (en) 1999-09-02 2004-04-06 Lexicon Genetics Incorporated Human calcium dependent proteases, polynucleotides encoding the same, and uses thereof
US6225093B1 (en) 1999-09-07 2001-05-01 Decode Genetics Ehf. Detection of C4A deletion by long range PCR
US6849403B1 (en) 1999-09-08 2005-02-01 Exact Sciences Corporation Apparatus and method for drug screening
AU783968B2 (en) * 1999-09-08 2006-01-05 Lexicon Genetics Incorporated Human G-protein coupled 7 transmembrane receptor and polynucleotides encoding the same
US6586177B1 (en) * 1999-09-08 2003-07-01 Exact Sciences Corporation Methods for disease detection
AU767646B2 (en) 1999-09-10 2003-11-20 Geron Corporation Oligonucleotide N3'-P5' thiophosphoramidates: their synthesis and use
NZ517121A (en) 1999-09-13 2004-05-28 Nugen Technologies Inc Methods and compositions for linear isothermal amplification of polynucleotide sequences
US6692918B2 (en) 1999-09-13 2004-02-17 Nugen Technologies, Inc. Methods and compositions for linear isothermal amplification of polynucleotide sequences
US7211390B2 (en) * 1999-09-16 2007-05-01 454 Life Sciences Corporation Method of sequencing a nucleic acid
US7244559B2 (en) * 1999-09-16 2007-07-17 454 Life Sciences Corporation Method of sequencing a nucleic acid
US6998232B1 (en) 1999-09-27 2006-02-14 Quark Biotech, Inc. Methods of diagnosing bladder cancer
US6541252B1 (en) 2000-05-19 2003-04-01 Lexicon Genetics Incorporated Human kinases and polynucleotides encoding the same
DE60027027T2 (de) * 1999-09-29 2006-11-30 Diagnocure Inc. Pca3 mrna in gutartigen und bösartigen prostatageweben
US6271002B1 (en) 1999-10-04 2001-08-07 Rosetta Inpharmatics, Inc. RNA amplification method
WO2001027327A2 (en) 1999-10-08 2001-04-19 Protogene Laboratories, Inc. Method and apparatus for performing large numbers of reactions using array assembly
CA2387479A1 (en) 1999-10-11 2001-04-19 Lexicon Genetics Incorporated Human ldl receptor family proteins and polynucleotides encoding the same
US7332275B2 (en) 1999-10-13 2008-02-19 Sequenom, Inc. Methods for detecting methylated nucleotides
US20030207297A1 (en) * 1999-10-13 2003-11-06 Hubert Koster Methods for generating databases and databases for identifying polymorphic genetic markers
WO2001027275A1 (en) * 1999-10-13 2001-04-19 Lexicon Genetics Incorporated Novel human membrane proteins
KR20020064298A (ko) 1999-10-13 2002-08-07 시쿼넘, 인코포레이티드 다형성 유전 마커를 동정하기 위한 데이타베이스 및 이의제조 방법
EP1305412A2 (en) 1999-10-14 2003-05-02 Clontech Laboratories Inc. Anthozoa derived chromo/fluoroproteins and methods for using the same
US6297226B1 (en) 1999-10-15 2001-10-02 Neotherapeutics, Inc. Synthesis and methods of use of 9-substituted guanine derivatives
US6855806B1 (en) * 1999-10-15 2005-02-15 Curagen Corporation Thymosin beta 10-like proteins and nucleic acids encoding same
ATE402953T1 (de) * 1999-10-18 2008-08-15 Lexicon Pharmaceuticals Inc Menschliches chordin und polynukleotiden die dafür kodieren
US6268120B1 (en) 1999-10-19 2001-07-31 Gambro, Inc. Isoalloxazine derivatives to neutralize biological contaminants
AU784861B2 (en) 1999-10-21 2006-07-06 Case Western Reserve University Gene expression profiling of inflammatory bowel disease
US7364866B2 (en) * 1999-10-22 2008-04-29 Pharmacia & Upjohn Company Drosophila G protein coupled receptors, nucleic acids, and methods related to the same
US6436633B1 (en) 1999-10-22 2002-08-20 The Pennsylvania State University Human xenografts for microbicide testing and anatomical modeling
CA2388599A1 (en) 1999-10-22 2001-05-03 Pharmacia & Upjohn Company Drosophila g protein coupled receptors, nucleic acids, and methods related to the same
US20030162223A1 (en) * 1999-10-22 2003-08-28 Lowery David E. Drosophila G protein coupled receptors, nucleic acids, and methods related to the same
US6958225B2 (en) * 1999-10-27 2005-10-25 Affymetrix, Inc. Complexity management of genomic DNA
US7534568B2 (en) 1999-10-29 2009-05-19 Hologic Inc. Methods for detection of a target nucleic acid by forming a cleavage structure with a cleavage resistant probe
US7381532B2 (en) * 1999-10-29 2008-06-03 Stratagene California Compositions and methods for the detection of a nucleic acid using a cleavage reaction
US7838225B2 (en) 1999-10-29 2010-11-23 Hologic, Inc. Methods for detection of a target nucleic acid by forming a cleavage structure using a reverse transcriptase
CN1796404A (zh) 1999-10-29 2006-07-05 启龙有限公司 奈瑟球菌的抗原性肽
US7824859B2 (en) * 1999-10-29 2010-11-02 Cytyc Corporation Methods for detection of a target nucleic acid by forming a cleavage structure using an RNA polymerase
US6893819B1 (en) * 2000-11-21 2005-05-17 Stratagene California Methods for detection of a nucleic acid by sequential amplification
US6528254B1 (en) 1999-10-29 2003-03-04 Stratagene Methods for detection of a target nucleic acid sequence
US7118860B2 (en) 1999-10-29 2006-10-10 Stratagene California Methods for detection of a target nucleic acid by capture
BR0015367A (pt) * 1999-11-05 2002-07-23 Gerigene Medical Corp Aumento e reparo de defeitos nos tecidos moles relacionados com a idade
US20090074729A2 (en) * 1999-11-05 2009-03-19 Donald Kleinsek Augmentation and repair of spincter defects with cells including fibroblasts
JP4721603B2 (ja) * 1999-11-08 2011-07-13 栄研化学株式会社 変異および／または多型の検出方法
ES2258027T3 (es) 1999-11-08 2006-08-16 Eiken Kagaku Kabushiki Kaisha Metodo para detectar mutaciones y polimorfismos.
CA2389990C (en) 1999-11-10 2007-05-29 The University Of Washington Compositions and methods for modulation of plant cell division
CN1654641A (zh) 1999-11-10 2005-08-17 诺维信公司 Fungamyl样α－淀粉酶变体
EP2264439A3 (en) 1999-11-12 2011-01-19 E.I. Du Pont De Nemours And Company Fluorometer with low heat-generating light source
EP1921440A3 (en) 1999-11-12 2008-06-04 E.I. Dupont De Nemours And Company Fluorometer with low heat-generating light source
US6852986B1 (en) * 1999-11-12 2005-02-08 E. I. Du Pont De Nemours And Company Fluorometer with low heat-generating light source
US7030228B1 (en) 1999-11-15 2006-04-18 Miltenyi Biotec Gmbh Antigen-binding fragments specific for dendritic cells, compositions and methods of use thereof antigens recognized thereby and cells obtained thereby
US20030082534A1 (en) * 1999-11-16 2003-05-01 Peter Lind Novel G protein-coupled receptors
WO2001036473A2 (en) * 1999-11-16 2001-05-25 Pharmacia & Upjohn Company Human g protein-coupled receptors
SK287932B6 (sk) * 1999-11-17 2012-05-03 Roche Diagnostics Gmbh Magnetic glass particles, method for their preparation and uses thereof
US6649654B1 (en) 1999-11-23 2003-11-18 The Regents Of The University Of California Methods for identifying and using IKK inhibitors
US7208265B1 (en) 1999-11-24 2007-04-24 Xy, Inc. Method of cryopreserving selected sperm cells
US7115712B1 (en) 1999-12-02 2006-10-03 Maxygen, Inc. Cytokine polypeptides
CA2393447A1 (en) * 1999-12-07 2001-06-14 Lexicon Genetics Incorporated Novel human membrane proteins and polynucleotides encoding the same
CA2394921A1 (en) * 1999-12-07 2001-06-14 Anthony P. Shuber Supracolonic aerodigestive neoplasm detection
US6919174B1 (en) 1999-12-07 2005-07-19 Exact Sciences Corporation Methods for disease detection
US7205105B2 (en) * 1999-12-08 2007-04-17 Epoch Biosciences, Inc. Real-time linear detection probes: sensitive 5′-minor groove binder-containing probes for PCR analysis
US20030148301A1 (en) * 1999-12-10 2003-08-07 Toshiya Aono Method of detecting nucleotide polymorphism
US20020110831A1 (en) * 1999-12-10 2002-08-15 Schlag Edward William Method and apparatus for controlling an electric current through bio-molecules
NZ530816A (en) 1999-12-10 2005-10-28 Invitrogen Corp Use of multiple recombination sites with unique specificity in recombinational cloning
US6458538B1 (en) 1999-12-14 2002-10-01 Ptc Therapeutics, Inc. Methods of assaying for compounds that inhibit premature translation termination and nonsense-mediated RNA decay
CA2640686A1 (en) 1999-12-16 2001-06-21 Monsanto Technology Llc Novel plant expression constructs
US6582938B1 (en) 2001-05-11 2003-06-24 Affymetrix, Inc. Amplification of nucleic acids
US7521202B2 (en) * 1999-12-17 2009-04-21 The Board Of Regents Of The University Of Oklahoma Method and apparatus for the production of soluble MHC antigens and uses thereof
US6489114B2 (en) 1999-12-17 2002-12-03 Bio Merieux Process for labeling a ribonucleic acid, and labeled RNA fragments which are obtained thereby
US6902891B2 (en) 1999-12-17 2005-06-07 Bio Merieux Process for labeling a nucleic acid
US20060035338A1 (en) * 1999-12-17 2006-02-16 Pure Protein Llc Method and apparatus for the production of soluble MHC antigens and uses thereof
US20030166057A1 (en) * 1999-12-17 2003-09-04 Hildebrand William H. Method and apparatus for the production of soluble MHC antigens and uses thereof
US20060276629A9 (en) * 1999-12-17 2006-12-07 Hildebrand William H Purification and characterization of soluble human HLA proteins
CA2395247A1 (en) * 1999-12-22 2001-06-28 Lexicon Genetics Incorporated Novel human membrane proteins and polynucleotides encoding the same
AT409382B (de) 1999-12-22 2002-07-25 Baxter Ag Verfahren zur detektion, unterscheidung und quantifizierung von freien und eingekapselten nukleinsäuren in einer probe
ATE459716T1 (de) 1999-12-23 2010-03-15 Zymogenetics Inc Zytokin zcyt018
JP4860869B2 (ja) 1999-12-29 2012-01-25 オックスフォード ジーン テクノロジー アイピー リミティド 固相支持体上の複数のポリヌクレオチドを増幅し、検出する方法
US7250252B2 (en) 1999-12-30 2007-07-31 David Aaron Katz Amplification based polymorphism detection
US6544506B2 (en) 2000-01-05 2003-04-08 Yeda Research & Development Co. Ltd. Veto cells effective in preventing graft rejection and devoid of graft versus host potential
AU2001230912A1 (en) * 2000-01-11 2001-07-24 The Board Of Regents Of The University Of Nebraska Identification of virulence determinants
US6350599B1 (en) 2000-01-12 2002-02-26 Novozymes A/S Pullulanase variants and methods for preparing such variants with predetermined properties
US6329178B1 (en) 2000-01-14 2001-12-11 University Of Washington DNA polymerase mutant having one or more mutations in the active site
US6287779B1 (en) 2000-01-20 2001-09-11 E. & J. Gallo Winery Detection of fermentation-related microorganisms
WO2001053323A2 (en) 2000-01-24 2001-07-26 Ramot University Authority For Applied Research & Industrial Development Ltd. Plants tolerant of environmental stress conditions, methods of generating same and novel polynucleotide sequence utilized thereby
WO2001053537A2 (en) * 2000-01-24 2001-07-26 Dzgenes, Llc Nitric oxide synthase gene diagnostic polymorphisms
US20030022318A1 (en) * 2000-01-25 2003-01-30 Epiclone, Inc. Method for thermocycling amplification of nucleic acid sequences and the generation of related peptides thereof
US6541225B1 (en) * 2000-01-26 2003-04-01 Raven Biotechnologies, Inc. Methods and compositions for generating human monoclonal antibodies
US6618679B2 (en) 2000-01-28 2003-09-09 Althea Technologies, Inc. Methods for analysis of gene expression
AU2001238011A1 (en) 2000-01-31 2001-08-07 Board Of Regents, The University Of Texas System System for transferring fluid samples through a sensor array
US6844321B2 (en) 2000-01-31 2005-01-18 Novo Nordisk A/S Crystallization of a GLP-1 analogue
EP1257579B1 (en) * 2000-02-04 2009-08-05 Lexicon Pharmaceuticals, Inc. Novel human g protein coupled receptor proteins and polynucleotides encoding the same
US8076063B2 (en) 2000-02-07 2011-12-13 Illumina, Inc. Multiplexed methylation detection methods
US7955794B2 (en) 2000-09-21 2011-06-07 Illumina, Inc. Multiplex nucleic acid reactions
US7582420B2 (en) 2001-07-12 2009-09-01 Illumina, Inc. Multiplex nucleic acid reactions
WO2001060393A1 (en) * 2000-02-16 2001-08-23 Bechtel Bwxt Idaho, Llc Selective destruction of cells infected with human immunodeficiency virus
EP1259624B1 (en) 2000-02-17 2008-05-14 Qiagen GmbH Thermostable chimeric nucleic acid polymerases and uses thereof
US20020151040A1 (en) 2000-02-18 2002-10-17 Matthew O' Keefe Apparatus and methods for parallel processing of microvolume liquid reactions
GB0004312D0 (en) 2000-02-23 2000-04-12 Oxagen Limited Test and model for inflammatory disease
US6498026B2 (en) 2000-02-25 2002-12-24 Hercules Incorporated Variant galactose oxidase, nucleic acid encoding same, and methods of using same
AU2001243345A1 (en) 2000-02-29 2001-09-12 Millennium Pharmaceuticals, Inc. 1983, 52881, 2398, 45449, 50289, and 52872, g protein-coupled receptors and uses therefor
US6872552B2 (en) * 2000-02-29 2005-03-29 Burt D. Ensley Method of reconstituting nucleic acid molecules
EP1944310A3 (en) 2000-03-01 2008-08-06 Epoch Biosciences, Inc. Modified oligonucleotides for mismatch discrimination
US20040002068A1 (en) 2000-03-01 2004-01-01 Corixa Corporation Compositions and methods for the detection, diagnosis and therapy of hematological malignancies
JP2003525292A (ja) 2000-03-01 2003-08-26 エポック・バイオサイエンシーズ・インコーポレイテッド ミスマッチ識別のための修飾オリゴヌクレオチド
US6436677B1 (en) 2000-03-02 2002-08-20 Promega Corporation Method of reverse transcription
US6632645B1 (en) * 2000-03-02 2003-10-14 Promega Corporation Thermophilic DNA polymerases from Thermoactinomyces vulgaris
US20030129724A1 (en) 2000-03-03 2003-07-10 Grozinger Christina M. Class II human histone deacetylases, and uses related thereto
US20030065155A1 (en) * 2000-03-06 2003-04-03 Nassim Usman Nucleic acid sensor molecules
US7087383B2 (en) 2000-03-07 2006-08-08 Hisamitsu Pharmaceutical Co., Inc. Nucleic acid sequences showing enhanced expression in benign neuroblastoma compared with acritical human neuroblastoma
TW201006846A (en) 2000-03-07 2010-02-16 Senomyx Inc T1R taste receptor and genes encidung same
WO2001066801A2 (en) 2000-03-08 2001-09-13 Complexe Hospitalier De La Sagamie Very low density lipoprotein receptor polymorphisms and uses therefor
CN101532001A (zh) 2000-03-08 2009-09-16 诺维信公司 具有改变的特性的变体
US7060467B2 (en) * 2000-03-13 2006-06-13 Monsanto Technology Llc Recombinant proteins containing repeating units
US6528060B1 (en) 2000-03-16 2003-03-04 Genzyme Corporation Therapeutic compounds
US20020012971A1 (en) * 2000-03-20 2002-01-31 Mehta Tammy Burd PCR compatible nucleic acid sieving medium
WO2001070767A2 (en) * 2000-03-20 2001-09-27 Genzyme Corporation Therapeutic anti-melanoma compounds
ES2254387T3 (es) * 2000-03-21 2006-06-16 Genzyme Corporation Compuestos anticitomegalovirus terapeuticos.
US6686461B1 (en) 2000-03-22 2004-02-03 Solulink Bioscience, Inc. Triphosphate oligonucleotide modification reagents and uses thereof
US7102024B1 (en) 2000-08-01 2006-09-05 Schwartz David A Functional biopolymer modification reagents and uses thereof
WO2001073128A1 (en) * 2000-03-24 2001-10-04 Dzgenes, Llc DIAGNOSTIC POLYMORPHISMS OF TGF-β-RII PROMOTER
US7829313B2 (en) * 2000-03-24 2010-11-09 Eppendorf Array Technologies Identification and quantification of a plurality of biological (micro)organisms or their components
US7875442B2 (en) 2000-03-24 2011-01-25 Eppendorf Array Technologies Identification and quantification of a plurality of biological (micro)organisms or their components
ATE472601T1 (de) 2000-03-27 2010-07-15 Technion Res And Dev Of Founda Einkettige haupthistokompatibilitätskomplexe der klasse i (mhc-i), kodierende konstrukte und methoden ihrer erzeugung
EP1950313A3 (en) 2000-03-27 2010-12-08 GlaxoSmithKline LLC Detection of viable agents
ES2548381T3 (es) 2000-03-27 2015-10-16 Thomas Jefferson University Composiciones para el tratamiento e imágenes de células de cáncer estomacales y de esófago
US6677146B1 (en) * 2000-03-28 2004-01-13 Replidyne, Inc. Thermophilic polymerase III holoenzyme
JP3628232B2 (ja) * 2000-03-31 2005-03-09 三洋電機株式会社 微生物識別方法、微生物識別装置、微生物識別用データベースの作成方法および微生物識別プログラムを記録した記録媒体
WO2001075139A1 (en) * 2000-04-03 2001-10-11 Biolink Partners, Inc. Reversible chemical modification of nucleic acids and improved method for nucleic acid hybridization
JP4726381B2 (ja) * 2000-04-07 2011-07-20 栄研化学株式会社 ２本鎖核酸を鋳型とする核酸の増幅方法
CA2405715C (en) * 2000-04-14 2011-11-15 Genencor International, Inc. Methods for selective targeting
AU2001293366A1 (en) 2000-04-14 2001-10-30 Cornell Research Foundation, Inc. Method of designing addressable array for detection of nucleic acid sequence differences using ligase detection reaction
US7129326B2 (en) * 2000-04-14 2006-10-31 Genencor International, Inc. Methods for selective targeting
AU2001253594A1 (en) * 2000-04-17 2001-10-30 Pharmacia And Upjohn Company Novel g protein-coupled receptors
US6248567B1 (en) 2000-04-24 2001-06-19 Wisconsin Alumni Research Foundation Template-specific termination in a polymerase chain reaction
IL135884A (en) * 2000-04-30 2005-08-31 Yissum Res Dev Co Method for measuring non-transferrin bound iron
US7262006B1 (en) 2000-05-01 2007-08-28 Ortho-Clinical Diagnostics, Inc. Rapid and efficient capture of DNA from sample without using cell lysing reagent
WO2001083828A1 (en) * 2000-05-04 2001-11-08 Dzgenes, Llc TGFβ-RII PROMOTER POLYMORPHISMS
US20030219786A1 (en) * 2000-08-11 2003-11-27 Applied Research Systems Ars Holding N.V. Novel glycoproteins and methods of use thereof
AU5961201A (en) * 2000-05-08 2001-11-20 Upjohn Co Novel g protein-coupled receptors
US20040005554A1 (en) * 2000-05-08 2004-01-08 Tayar Nabil El Novel glycoproteins and methods of use thereof
AU2001263039B2 (en) 2000-05-09 2006-07-13 Xy, Llc. High purity x-chromosome bearing and y-chromosome bearing populations of spermatozoa
US6680172B1 (en) 2000-05-16 2004-01-20 Regents Of The University Of Michigan Treatments and markers for cancers of the central nervous system
EP1349954B1 (en) * 2000-05-19 2011-01-26 Eragen Biosciences, Inc. Materials and methods for detection of nucleic acids
US6573370B1 (en) 2000-05-19 2003-06-03 Regents Of The University Of Michigan PON3 and uses thereof
US20020120409A1 (en) * 2000-05-19 2002-08-29 Affymetrix, Inc. Methods for gene expression analysis
US7244560B2 (en) * 2000-05-21 2007-07-17 Invitrogen Corporation Methods and compositions for synthesis of nucleic acid molecules using multiple recognition sites
US6734005B2 (en) * 2000-05-22 2004-05-11 Pharmacia & Upjohn Company Matrix metalloproteinases
CA2408574A1 (en) * 2000-05-24 2001-11-29 Micronics, Inc. Microfluidic concentration gradient loop
US20030009016A1 (en) * 2000-05-25 2003-01-09 Shimkets Richard A. Nucleic acids containing single nucleotide polymorphisms and methods of use thereof
US7078208B2 (en) 2000-05-26 2006-07-18 Invitrogen Corporation Thermostable reverse transcriptases and uses thereof
US6790667B1 (en) * 2000-05-30 2004-09-14 Lexicon Genetics Incorporated Human mitochondrial proteins and polynucleotides encoding the same
US20020155471A1 (en) * 2000-05-31 2002-10-24 Nicolette Charles A. Compounds for therapy and diagnosis and methods for using same
ATE292640T1 (de) * 2000-05-31 2005-04-15 Genzyme Corp Therapeutische verbindungen gegen eierstockkrebs
US7648699B2 (en) 2000-06-02 2010-01-19 Caridianbct Biotechnologies, Llc Preventing transfusion related complications in a recipient of a blood transfusion
US7700359B2 (en) 2000-06-02 2010-04-20 Novartis Vaccines And Diagnostics, Inc. Gene products differentially expressed in cancerous cells
TW590780B (en) 2000-06-02 2004-06-11 Gambro Inc Additive solutions containing riboflavin
US20020039736A1 (en) 2000-06-05 2002-04-04 Byrne Michael C. Compositions, kits, and methods for identification and modulation of type I diabetes
EP2351853A1 (en) 2000-06-06 2011-08-03 Life Technologies Corporation Method and devices for multiplexing amplification reactions
US6214557B1 (en) 2000-06-06 2001-04-10 Washington University Cold sensitive mutant DNA polymerases
JP2003535599A (ja) 2000-06-06 2003-12-02 ティーエム バイオサイエンス コーポレイション 核酸の捕捉部とその使用
US7087414B2 (en) 2000-06-06 2006-08-08 Applera Corporation Methods and devices for multiplexing amplification reactions
US6605451B1 (en) 2000-06-06 2003-08-12 Xtrana, Inc. Methods and devices for multiplexing amplification reactions
US6887664B2 (en) 2000-06-06 2005-05-03 Applera Corporation Asynchronous primed PCR
EP1286682B1 (en) 2000-06-08 2010-03-03 Immune Disease Institute, Inc. Methods and compositions for inhibiting immunoglobulin-mediated-reperfusion injury
WO2001094417A2 (en) * 2000-06-09 2001-12-13 Lexicon Genetics Incorporated Novel human seven transmembrane proteins and polynucleotides encoding the same
EP1734050A3 (en) 2000-06-12 2012-12-05 University Of Saskatchewan Immunization of dairy cattle with GapC protein against streptococcus infection
US9044523B2 (en) 2000-06-15 2015-06-02 Terumo Bct, Inc. Reduction of contaminants in blood and blood products using photosensitizers and peak wavelengths of light
US7259244B2 (en) 2000-06-16 2007-08-21 Nerviano Medical Sciences S.R.L. Human homologue of the DBF4/ASK1 protein, nucleic acids, and methods related to the same
BRPI0100752B1 (pt) 2000-06-22 2015-10-13 Monsanto Co moléculas e pares de moléculas de dna, processos para detectar molécula de dna e para criar um traço tolerante a glifosato em plantas de milho, bem como kit de detecção de dna
AU2001265835A1 (en) 2000-06-23 2002-01-08 Novozymes A/S Method for stable chromosomal multi-copy integration of genes
DK1325115T3 (en) 2000-06-26 2016-11-21 Zymogenetics Inc CYTOKINRECEPTOR ZCYTOR17
CA2412721A1 (en) 2000-06-26 2002-01-03 Nugen Technologies, Inc. Methods and compositions for transcription-based nucleic acid amplification
US7846733B2 (en) 2000-06-26 2010-12-07 Nugen Technologies, Inc. Methods and compositions for transcription-based nucleic acid amplification
AU7309601A (en) 2000-06-28 2002-01-08 Genetics Inst Pd-l2 molecules: novel pd-1 ligands and uses therefor
US6420144B1 (en) 2000-06-28 2002-07-16 Salus Therapeutics, Inc. Method for automated molecular cloning
US6686157B2 (en) 2000-06-30 2004-02-03 Molecular Staging Inc. Signal amplification with lollipop probes
ES2311253T3 (es) 2000-06-30 2009-02-01 Zymogenetics, Inc. Variante alelico de una proteina zcyt021 de tipo interferon.
US20040023230A1 (en) * 2000-06-30 2004-02-05 Alexander Olek Method and nucleic acids for pharmacogenomic methylation analysis
GB0016516D0 (en) * 2000-07-06 2000-08-23 Owen Mumford Ltd Improvements relating to needle protection devices
US7488576B2 (en) * 2000-07-06 2009-02-10 The Regents Of The University Of California Methods for diagnosis and treatment of psychiatric disorders
FR2811323B1 (fr) * 2000-07-07 2006-10-06 Fuma Tech Gmbh Materiau hybride, utilisation dudit materiau hybride et procede de sa fabrication
CA2415422C (en) 2000-07-10 2014-07-08 Board Of Regents, The University Of Texas System Chromosome 3p21.3 genes are tumor suppressors
US6958214B2 (en) 2000-07-10 2005-10-25 Sequenom, Inc. Polymorphic kinase anchor proteins and nucleic acids encoding the same
JP2004514418A (ja) * 2000-07-11 2004-05-20 ホーガン　カーク 周術期ゲノムプロファイリングの方法および組成物
US20050226845A1 (en) * 2004-03-10 2005-10-13 Chih-Ping Liu Method of treatment using interferon-tau
US20040247565A1 (en) * 2000-07-19 2004-12-09 Chih-Ping Liu Method of treatment using interferon-tau
US7431920B2 (en) * 2000-07-19 2008-10-07 Pepgen Corporation Method of treating IL-10 deficiency
JP2006213597A (ja) * 2000-07-19 2006-08-17 Pepgen Corp インターフェロン−タウを用いるｃ型肝炎ウイルスの処置のための組成物およびモニタリングの方法
US7105154B2 (en) * 2000-07-19 2006-09-12 Pepgen Corporation Method of treatment using interferon-tau
US20050201981A1 (en) * 2004-03-10 2005-09-15 Chih-Ping Liu Method of optimizing treatment with interferon-tau
HUP0300810A2 (hu) 2000-07-20 2003-08-28 M.G.V.S. Ltd. Mesterséges értranszplantátum, valamint ennek létrehozása és alkalmazása
US6878861B2 (en) * 2000-07-21 2005-04-12 Washington State University Research Foundation Acyl coenzyme A thioesterases
AU2001280752A1 (en) * 2000-07-25 2002-02-05 Dzgenes, L.L.C. Diagnostic polymorphisms for the ecnos promoter
US20040023259A1 (en) * 2000-07-26 2004-02-05 Luca Rastelli Therapeutic polypeptides, nucleic acids encoding same, and methods of use
US20040037828A1 (en) 2002-07-09 2004-02-26 Bar-Ilan University Methods and pharmaceutical compositions for healing wounds
US6602707B2 (en) 2000-08-01 2003-08-05 Oregon Health & Science University Mammalian cell surface DNA receptor-encoding nucleic acid
AU2001278415A1 (en) 2000-08-01 2002-02-13 Novozymes A/S Alpha-amylase mutants with altered stability
US7662791B2 (en) 2000-08-02 2010-02-16 University Of Southern California Gene silencing using mRNA-cDNA hybrids
US20080242627A1 (en) * 2000-08-02 2008-10-02 University Of Southern California Novel rna interference methods using dna-rna duplex constructs
ATE384731T1 (de) 2000-08-03 2008-02-15 Hoffmann La Roche Nukleinsäurebindende verbindungen mit pyrazolo 3, 4-d pyrimidinanalogen von purin-2,6-diamin und ihre verwendung
US7288390B2 (en) 2000-08-07 2007-10-30 Centocor, Inc. Anti-dual integrin antibodies, compositions, methods and uses
UA81743C2 (uk) 2000-08-07 2008-02-11 Центокор, Инк. МОНОКЛОНАЛЬНЕ АНТИТІЛО ЛЮДИНИ, ЩО СПЕЦИФІЧНО ЗВ'ЯЗУЄТЬСЯ З ФАКТОРОМ НЕКРОЗУ ПУХЛИН АЛЬФА (ФНПα), ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ, ЩО ЙОГО МІСТИТЬ, ТА СПОСІБ ЛІКУВАННЯ РЕВМАТОЇДНОГО АРТРИТУ
US6902734B2 (en) 2000-08-07 2005-06-07 Centocor, Inc. Anti-IL-12 antibodies and compositions thereof
US20030114410A1 (en) * 2000-08-08 2003-06-19 Technion Research And Development Foundation Ltd. Pharmaceutical compositions and methods useful for modulating angiogenesis and inhibiting metastasis and tumor fibrosis
EP1315519B1 (en) 2000-08-08 2010-12-29 Technion Research And Development Foundation Ltd. Pharmaceutical compositions and methods useful for treating cancer or liver fibrosis
EP1311686A2 (en) 2000-08-14 2003-05-21 THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES Modifications of hiv env, gag, and pol enhance immunogenicity for genetic immunization
US20030032019A1 (en) * 2000-08-15 2003-02-13 Peter Lind Novel G protein-coupled receptors
US6545758B1 (en) * 2000-08-17 2003-04-08 Perry Sandstrom Microarray detector and synthesizer
US6680059B2 (en) * 2000-08-29 2004-01-20 Tripep Ab Vaccines containing ribavirin and methods of use thereof
US6858590B2 (en) * 2000-08-17 2005-02-22 Tripep Ab Vaccines containing ribavirin and methods of use thereof
US6567163B1 (en) 2000-08-17 2003-05-20 Able Signal Company Llc Microarray detector and synthesizer
US7022830B2 (en) * 2000-08-17 2006-04-04 Tripep Ab Hepatitis C virus codon optimized non-structural NS3/4A fusion gene
US7198924B2 (en) 2000-12-11 2007-04-03 Invitrogen Corporation Methods and compositions for synthesis of nucleic acid molecules using multiple recognition sites
JP2004506447A (ja) * 2000-08-22 2004-03-04 レキシコン・ジェネティクス・インコーポレーテッド 新規ヒト７ｔｍタンパクおよびそれをコードするポリヌクレオチド
US6803211B2 (en) 2000-08-25 2004-10-12 Pfizer Inc. Methods and compositions for diagnosing and treating disorders involving angiogenesis
EP1197550A3 (en) * 2000-08-25 2002-11-20 Pfizer Products Inc. Methods and compositions for diagnosing and treating disorders involving angiogenesis
US7214485B2 (en) 2000-08-25 2007-05-08 Lovelace Respiratory Research Institute Nested methylation-specific polymerase chain reaction cancer detection method
US6759525B2 (en) 2000-08-25 2004-07-06 The United States Of America As Represented By The Department Of Health And Human Services Protein kinase A and carney complex
EP1683874A3 (en) 2000-08-29 2006-10-11 YEDA RESEARCH AND DEVELOPMENT Co. LTD. Methods of isolating genes encoding proteins of specific function and of screening for pharmaceutically active agents
GB0021286D0 (en) * 2000-08-30 2000-10-18 Gemini Genomics Ab Identification of drug metabolic capacity
US6849407B2 (en) 2000-08-31 2005-02-01 Mayo Foundation For Medical Education And Research Detection of varicella-zoster virus
ATE414794T1 (de) 2000-09-01 2008-12-15 Gen Probe Inc Amplifizierung von hiv-1 sequenzen zur detektion von sequenzen, die mit wirkstoff-resistenz mutationen einhergehen
US6640891B1 (en) 2000-09-05 2003-11-04 Kevin R. Oldenburg Rapid thermal cycling device
US7025120B2 (en) * 2000-09-05 2006-04-11 Oldenburg Kevin R Rapid thermal cycling device
US20020058265A1 (en) 2000-09-15 2002-05-16 Promega Corporation Detection of microsatellite instability and its use in diagnosis of tumors
US6844152B1 (en) * 2000-09-15 2005-01-18 Promega Corporation Detection of microsatellite instability and its use in diagnosis of tumors
JP2004513332A (ja) * 2000-09-18 2004-04-30 ジェンザイム、コーポレーション 質量分析法（ｍａｌｄｉ−ｔｏｆ）に基づいて抗体標的を同定するための方法
AU2001292728A1 (en) * 2000-09-18 2002-03-26 Thomas Jefferson University Compositions and methods for identifying and targeting stomach and esophageal cancer cells
UA83458C2 (uk) 2000-09-18 2008-07-25 Байоджен Айдек Ма Інк. Виділений поліпептид baff-r (рецептор фактора активації в-клітин сімейства tnf)
ES2394481T3 (es) * 2000-09-21 2013-02-01 Basf Se Xilanasa de talaromyces
US20020086313A1 (en) * 2000-09-25 2002-07-04 Kilbane John J. Application of bioinformatics for direct study of unculturable microorganisms
US6916635B2 (en) * 2000-10-02 2005-07-12 The Research Foundation Of State University Of New York Hybrid adenovirus/adeno-associated virus vectors and methods of use thereof
US20040209303A1 (en) 2000-10-03 2004-10-21 Martin Mark T. Methods and compositions for directed microwave chemistry
US7348182B2 (en) * 2000-10-03 2008-03-25 Mirari Biosciences, Inc. Directed microwave chemistry
AU2002211477A1 (en) * 2000-10-05 2002-04-15 Case Western Reserve University Suppressor of human breast cancer cell growth
DE10049211A1 (de) * 2000-10-05 2002-04-18 Qiagen Gmbh Thermostabile Polymerase aus Thermococcus pacificus
JP2004537257A (ja) 2000-10-06 2004-12-16 ニューゲン テクノロジーズ， インコーポレイテッド 核酸配列の検出および／または定量のための、方法およびプローブ
US20090062512A1 (en) * 2000-10-10 2009-03-05 Hildebrand William H Comparative ligand mapping from MHC class I positive cells
US20050003483A1 (en) * 2000-10-10 2005-01-06 Hildebrand William H. Comparative ligand mapping from MHC class 1 positive cells
US20070099182A1 (en) * 2000-10-10 2007-05-03 Hildebrand William H Comparative ligand mapping from MHC class I positive cells
IL155307A0 (en) * 2000-10-10 2003-11-23 Univ Oklahoma Methods for isolating, identifying and purifying peptide ligands and peptide ligands produced thereby
WO2002031197A1 (en) 2000-10-10 2002-04-18 Wunderink Richard G Method for identifying increased risk of death from community acquired pneumonia
US6951739B2 (en) 2000-10-12 2005-10-04 Marical, Inc. Polyvalent cation-sensing receptor in atlantic salmon
US6979559B2 (en) * 2000-10-12 2005-12-27 Marical, Inc. Polyvalent cation-sensing receptor in atlantic salmon
US7101988B2 (en) * 2000-10-12 2006-09-05 Marical, Inc. Polyvalent cation-sensing receptor in Atlantic salmon
US6979558B2 (en) 2000-10-12 2005-12-27 Marical, Inc. Polyvalent cation-sensing receptor in Atlantic salmon
EP1358352B1 (en) * 2000-10-14 2009-02-11 Eragen Biosciences, Inc. Solid support assay systems and methods utilizing non-standard bases
NZ525336A (en) * 2000-10-20 2006-03-31 Expression Diagnostics Inc Leukocyte expression profiling
WO2002070705A2 (en) * 2000-10-27 2002-09-12 Lexicon Genetics Incorporated Human 7tm proteins and polynucleotides encoding them
AU2002214127B2 (en) 2000-10-27 2007-06-07 J. Craig Venter Institute, Inc. Nucleic acids and proteins from streptococcus groups A and B
JP2004531209A (ja) * 2000-10-30 2004-10-14 レキシコン・ジェネティクス・インコーポレーテッド 新規ヒト７ｔｍタンパクおよびそれをコードするポリヌクレオチド
US7060442B2 (en) 2000-10-30 2006-06-13 Regents Of The University Of Michigan Modulators on Nod2 signaling
US6902933B2 (en) * 2000-11-03 2005-06-07 Regents Of The University Of Michigan Surface transfection and expression procedure
US6897067B2 (en) 2000-11-03 2005-05-24 Regents Of The University Of Michigan Surface transfection and expression procedure
JP2005505231A (ja) * 2000-11-03 2005-02-24 リージェンツ オブ ザ ユニバーシティ オブ ミシガン 表面トランスフェクションおよび発現法
US7226764B1 (en) 2000-11-08 2007-06-05 The Board Of Trustees Operating Michigan State University Compositions and methods for the synthesis and subsequent modification of uridine-5′-diphosphosulfoquinovose (UDP-SQ)
US6544782B1 (en) 2000-11-13 2003-04-08 Synthegen Systems pREM: a positive selection vector system for direct PCR cloning
US7575924B2 (en) 2000-11-13 2009-08-18 Research Development Foundation Methods and compositions relating to improved lentiviral vectors and their applications
CA2428798C (en) * 2000-11-15 2013-09-03 Third Wave Technologies, Inc. Fen-1 endonucleases from archaeoglobus veneficus
AU2002230524A1 (en) * 2000-11-16 2002-05-27 California Institute Of Technology Apparatus and methods for conducting assays and high throughput screening
US7858559B2 (en) 2000-11-17 2010-12-28 University Of Rochester In vitro methods of producing and identifying immunoglobulin molecules in eukaryotic cells
US8071740B2 (en) 2000-11-17 2011-12-06 Vascular Biogenics Ltd. Promoters exhibiting endothelial cell specificity and methods of using same for regulation of angiogenesis
US20030119094A1 (en) * 2001-09-24 2003-06-26 Irm Llc Solubility reporter gene constructs
US7309573B2 (en) * 2000-11-21 2007-12-18 Stratagene California Methods for detection of a nucleic acid by sequential amplification
EP1356108A2 (en) 2000-11-28 2003-10-29 Wyeth Expression analysis of fkbp nucleic acids and polypeptides useful in the diagnosis and treatment of prostate cancer
HUP0303905A3 (en) 2000-11-28 2005-11-28 Wyeth Corp Expression analysis of kiaa nucleic acids and polypeptides useful in the diagnosis and treatment of prostate cancer
WO2002059366A2 (en) * 2000-11-28 2002-08-01 Promega Corporation Rna polymers and uses thereof
US20040082068A1 (en) * 2000-11-28 2004-04-29 Lawrence Kleiman Incorporation and priming function of trnalys in hiv and related viruses
US7713687B2 (en) 2000-11-29 2010-05-11 Xy, Inc. System to separate frozen-thawed spermatozoa into x-chromosome bearing and y-chromosome bearing populations
BRPI0115791B1 (pt) 2000-11-29 2020-05-05 Colorado State Univ sistema para fertilização in vitro com espematozóides separados em populações portadoras de cromossoma x e cromossoma y
US20080261220A1 (en) * 2000-11-30 2008-10-23 Third Wave Technologies, Inc. Nucleic Acid Detection Assays
AU2002221013A1 (en) * 2000-11-30 2002-06-11 Yeda Research And Development Co..Ltd. Methods of utilizing cultured non-gvhd inducing t lymphocytes to treat disease
EP1354064A2 (en) 2000-12-01 2003-10-22 Visigen Biotechnologies, Inc. Enzymatic nucleic acid synthesis: compositions and methods for altering monomer incorporation fidelity
CA2429769C (en) * 2000-12-07 2016-04-26 Board Of Regents, The University Of Texas System Methods of treatment involving human mda-7
WO2002046477A2 (en) 2000-12-07 2002-06-13 Chiron Corporation Endogenous retroviruses up-regulated in prostate cancer
AR031640A1 (es) 2000-12-08 2003-09-24 Applied Research Systems Amplificacion isotermica de acidos nucleicos en un soporte solido
WO2002046372A1 (en) 2000-12-08 2002-06-13 Invitrogen Corporation Methods and compositions for synthesis of nucleic acid molecules using multiple recognition sites
AU2002230788A1 (en) * 2000-12-11 2002-06-24 Hk Pharmaceuticals, Inc. Multiplexed protein expression and activity assay
CA2436693A1 (en) 2000-12-11 2002-06-20 Alexion Pharmaceuticals, Inc. Nested oligonucleotides containing hairpin for nucleic acid amplification
US6958213B2 (en) 2000-12-12 2005-10-25 Alligator Bioscience Ab Method for in vitro molecular evolution of protein function
ATE475720T1 (de) 2000-12-13 2010-08-15 Nugen Technologies Inc Methoden und zusammensetzungen zur generierung einer vielzahl von kopien von nukleinsäuresequenzen und methoden zur detektion derselben
MXPA03005388A (es) * 2000-12-14 2003-09-25 Amylin Pharmaceuticals Inc Peptido yy y agonistas de peptido yy para el tratamiento de desordenes metabolicos.
US20030215813A1 (en) * 2000-12-14 2003-11-20 Roberds Steven L. Human ion channels
CA2436857A1 (en) * 2000-12-14 2002-06-20 Gen-Probe Incorporated Method and kit for enhancing the association rates of polynucleotides
US20070026433A1 (en) * 2001-03-09 2007-02-01 Hildebrand William H Epitope testing using soluble HLA
CN1288247C (zh) 2000-12-18 2006-12-06 孟山都技术公司 Arcelin－5启动子及其应用
US6706867B1 (en) 2000-12-19 2004-03-16 The United States Of America As Represented By The Department Of Health And Human Services DNA array sequence selection
US20040053839A1 (en) * 2000-12-21 2004-03-18 Andrea Leblanc Method of protecting cells against apoptosis and assays to identify agents which modulate apoptosis
US20020086292A1 (en) 2000-12-22 2002-07-04 Shigeaki Harayama Synthesis of hybrid polynucleotide molecules using single-stranded polynucleotide molecules
US6794141B2 (en) 2000-12-22 2004-09-21 Arcturus Bioscience, Inc. Nucleic acid amplification
ATE519783T1 (de) * 2000-12-22 2011-08-15 Grad Carole Legal Representative Of Kaplan Howard ßPHAGE DISPLAYß BIBLIOTHEKE VON MENSCHLICHEN VH FRAGMENTEN
TW201022287A (en) 2001-01-03 2010-06-16 Senomyx Inc T1R taste receptors and genes encoding same
EP1390530A2 (en) * 2001-01-05 2004-02-25 Genomicfx, Inc. Method for relative quantification of attached nucleic acids
US6964849B2 (en) 2001-01-11 2005-11-15 Curagen Corporation Proteins and nucleic acids encoding same
US20020122820A1 (en) * 2001-01-16 2002-09-05 Hildebrand William H. Soluble MHC artificial antigen presenting cells
JP2004526431A (ja) * 2001-01-17 2004-09-02 ラモト アット テル アヴィヴ ユニヴァーシティ リミテッド 食虫植物に由来するキチナーゼ、該キチナーゼをコードするポリヌクレオチド配列、ならびに該キチナーゼを単離および使用する方法
ES2185472B1 (es) 2001-01-23 2004-10-16 Universidad De Salamanca (O.T.R.I.) Empleo del gen slug, o de sus productos de transcripcion o expresion, en la deteccion y/o tratamiento de celulas cancerosas.
US20040043928A1 (en) * 2001-08-02 2004-03-04 Ramesh Kekuda Therapeutic polypeptides, nucleic acids encoding same, and methods of use
US6635451B2 (en) * 2001-01-25 2003-10-21 Abbott Laboratories Desaturase genes and uses thereof
US7054758B2 (en) * 2001-01-30 2006-05-30 Sciona Limited Computer-assisted means for assessing lifestyle risk factors
US20050202098A1 (en) 2001-01-31 2005-09-15 Tolaren Disease therapy using dying or dead cells
AU2002230061A1 (en) * 2001-01-31 2002-08-12 Tolaren Induction of tolerance by apoptotic and/or necrotic cells
EP1364063B1 (en) * 2001-01-31 2010-04-21 Mayo Foundation For Medical Education And Research Detection of herpes simplex virus
WO2002061392A2 (en) * 2001-01-31 2002-08-08 Board Of Regents, The University Of Texas System Method and apparatus for the confinement of materials in a micromachined chemical sensor array
IL141392A0 (en) * 2001-02-12 2002-03-10 Gene Bio Applic Ltd Orientation-directed construction of plasmids
EP1387887A2 (en) 2001-02-13 2004-02-11 Children's Hospital Research Foundation Quantitative epstein barr virus pcr rapid assay
US20030113263A1 (en) * 2001-02-13 2003-06-19 Oregon Health And Sciences University, A Non-Profit Organization Methods and reagents for using mammalian melanocortin receptor antagonists to treat cachexia
US20050069976A1 (en) * 2001-02-14 2005-03-31 Peter Lind Protein-coupled receptor
US6566067B2 (en) * 2001-02-14 2003-05-20 Synthegen Systems, Inc. High fidelity PCR cloning
US6692700B2 (en) 2001-02-14 2004-02-17 Handylab, Inc. Heat-reduction methods and systems related to microfluidic devices
WO2002065136A2 (en) 2001-02-15 2002-08-22 University Of Chicago Yeast screens for agents affecting protein folding
CN100351393C (zh) 2001-02-15 2007-11-28 宝生物工程株式会社 核苷酸多态性的检测方法
US6867021B2 (en) 2001-02-20 2005-03-15 Board Of Trustees Of Michigan State University Multiplex RT-PCR/PCR for simultaneous detection of bovine coronavirus, bovine rotavirus, Cryptosporidium parvum, and Escherichia coli
US6620586B2 (en) * 2001-02-20 2003-09-16 Applied Gene Technologies, Inc. Methods and compositions for analyzing nucleic acids
US20020156773A1 (en) * 2001-02-21 2002-10-24 William Hildebrand Soluble HLA ligand database utilizing predictive algorithms and methods of making and using same
US20030091987A1 (en) * 2001-02-22 2003-05-15 Yamamoto Janet K. Materials and methods for detecting, preventing, and treating retroviral infection
US20040067511A1 (en) 2001-02-27 2004-04-08 Thomas David C. Circular probe amplification (cpa) using energy-transfer primers
US6849449B2 (en) * 2001-03-01 2005-02-01 Regents Of The University Of Michigan Orphanin FQ receptor nucleic acids
US7226739B2 (en) 2001-03-02 2007-06-05 Isis Pharmaceuticals, Inc Methods for rapid detection and identification of bioagents in epidemiological and forensic investigations
EP1236804A1 (en) * 2001-03-02 2002-09-04 Boehringer Mannheim Gmbh A method for determination of a nucleic acid using a control
US20040121313A1 (en) * 2002-12-06 2004-06-24 Ecker David J. Methods for rapid detection and identification of bioagents in organs for transplantation
US7666588B2 (en) 2001-03-02 2010-02-23 Ibis Biosciences, Inc. Methods for rapid forensic analysis of mitochondrial DNA and characterization of mitochondrial DNA heteroplasmy
US20030027135A1 (en) 2001-03-02 2003-02-06 Ecker David J. Method for rapid detection and identification of bioagents
US7718354B2 (en) 2001-03-02 2010-05-18 Ibis Biosciences, Inc. Methods for rapid identification of pathogens in humans and animals
ZA200210369B (en) 2001-03-09 2004-07-08 Nugen Technologies Inc Methods and compositions for amplification or RNA sequences.
US6645720B2 (en) * 2001-03-09 2003-11-11 Syngenta Participations Ag Detection of fungal pathogens using the polymerase chain reaction
EP1417487B1 (en) * 2001-03-09 2007-10-17 The Board Of Regents Of The University Of Oklahoma Epitope testing using hla
CA2439750A1 (en) 2001-03-09 2002-09-19 Boston Probes, Inc. Methods, kits and compositions pertaining to combination oligomers and libraries for their preparation
US6573051B2 (en) 2001-03-09 2003-06-03 Molecular Staging, Inc. Open circle probes with intramolecular stem structures
ES2180416B1 (es) 2001-03-12 2004-06-01 BIOTOOLS BIOTECHNOLOGICAL & MEDICAL LABORATORIES, S.A. Procedimiento para la preparacion de mezclas de reaccion estabilizadas, total o parcialmente desecadas, que comprenden, al menos, una enzima, mezclas de reaccion y kits que las contienen.
JP2004523243A (ja) * 2001-03-12 2004-08-05 カリフォルニア インスティチュート オブ テクノロジー 非同期性塩基伸長によってポリヌクレオチド配列を分析するための方法および装置
JP4413495B2 (ja) 2001-03-13 2010-02-10 ノバルティス アクチエンゲゼルシャフト レンチウィルスパッケージング構築物
US20030092157A1 (en) * 2001-03-16 2003-05-15 Hayden Michael R. Compositions, screening systems and methods for modulating HDL cholesterol and triglyceride levels
IL158000A0 (en) * 2001-03-19 2004-03-28 Harvard College Evolving new molecular function
US6528309B2 (en) 2001-03-19 2003-03-04 The Regents Of The University Of California Vacuum-mediated desiccation protection of cells
CA2342376C (en) * 2001-03-20 2013-11-12 Marco Colonna A receptor trem (triggering receptor expressed on myeloid cells) and uses thereof
US20090081199A1 (en) * 2001-03-20 2009-03-26 Bioxell S.P.A. Novel receptor trem (triggering receptor expressed on myeloid cells) and uses thereof
US8231878B2 (en) * 2001-03-20 2012-07-31 Cosmo Research & Development S.P.A. Receptor trem (triggering receptor expressed on myeloid cells) and uses thereof
IL142118A0 (en) * 2001-03-20 2002-03-10 Prochon Biotech Ltd Method and composition for treatment of skeletal dysplasias
US8981061B2 (en) 2001-03-20 2015-03-17 Novo Nordisk A/S Receptor TREM (triggering receptor expressed on myeloid cells) and uses thereof
ES2432967T3 (es) 2001-03-22 2013-12-05 Novo Nordisk Health Care Ag Derivados del Factor VII de coagulación
GB0107661D0 (en) 2001-03-27 2001-05-16 Chiron Spa Staphylococcus aureus
GB0107658D0 (en) 2001-03-27 2001-05-16 Chiron Spa Streptococcus pneumoniae
US7010391B2 (en) 2001-03-28 2006-03-07 Handylab, Inc. Methods and systems for control of microfluidic devices
US6852287B2 (en) 2001-09-12 2005-02-08 Handylab, Inc. Microfluidic devices having a reduced number of input and output connections
US6949340B2 (en) 2001-03-28 2005-09-27 Creative Mines Llc Optical phase modulator
US7323140B2 (en) 2001-03-28 2008-01-29 Handylab, Inc. Moving microdroplets in a microfluidic device
US8895311B1 (en) 2001-03-28 2014-11-25 Handylab, Inc. Methods and systems for control of general purpose microfluidic devices
US7829025B2 (en) * 2001-03-28 2010-11-09 Venture Lending & Leasing Iv, Inc. Systems and methods for thermal actuation of microfluidic devices
JP3945993B2 (ja) * 2001-03-29 2007-07-18 富士通株式会社 半導体記憶装置
US7115726B2 (en) * 2001-03-30 2006-10-03 Perlegen Sciences, Inc. Haplotype structures of chromosome 21
US6596489B2 (en) 2001-03-30 2003-07-22 Applied Gene Technologies Methods and compositions for analyzing nucleotide sequence mismatches using RNase H
AU785425B2 (en) * 2001-03-30 2007-05-17 Genetic Technologies Limited Methods of genomic analysis
CA2442066C (en) 2001-04-02 2005-11-01 Wyeth Pd-1, a receptor for b7-4, and uses therefor
US20030143556A1 (en) * 2001-04-03 2003-07-31 Gary Blackburn Nucleic acid reactions using labels with different redox potentials
AU2002256053A1 (en) * 2001-04-04 2002-10-21 Genzyme Corporation Novel bgp compounds for therapy and diagnosis and methods for using same
US20050196860A1 (en) * 2001-04-04 2005-09-08 Nicolette Charles A. Novel EPS8 compounds for therapy and diagnosis and methods for using same
FR2823064B1 (fr) * 2001-04-04 2004-05-28 Biogemma Fr Procede d'obtention de plantes c4 a metabolisme carbone modifie
WO2002081715A1 (en) * 2001-04-04 2002-10-17 Mcgill University A transgenic non-human animal having a disruption of at least one allele to the ceacam1 gene and method of making same
US7883856B2 (en) 2001-04-05 2011-02-08 Senomyx Inc. Identification of bitter ligands that specifically activate human T2R receptors and related assays for identifying human bitter taste modulators
US7169597B2 (en) * 2001-04-13 2007-01-30 Michigan State University Compositions and methods for the production of betaine lipids
US7241935B2 (en) * 2001-04-13 2007-07-10 The Board Of Trustees Operating Michigan State University Compositions and methods for the production of betaine lipids
KR100886095B1 (ko) 2001-04-16 2009-02-27 와이어쓰 홀딩스 코포레이션 폴리펩티드 항원을 암호화하는 신규한 스트렙토코쿠스 뉴모니애 개방형 판독 프레임 및 이를 포함하는 조성물
AUPR446701A0 (en) 2001-04-18 2001-05-17 Gene Stream Pty Ltd Transgenic mammals for pharmacological and toxicological studies
EP1390394A4 (en) * 2001-04-19 2004-05-26 Invitrogen Corp COMPOSITIONS AND METHODS FOR RECOMBINANT CLONING OF NUCLEIC ACID MOLECULES
AR035832A1 (es) * 2001-04-23 2004-07-14 Monsanto Technology Llc Monitoreo basado en pcr en sistemas de biotratamiento de agua de desecho
EP1470245A4 (en) * 2001-04-24 2005-08-31 Pharmacia & Upjohn Co Llc SINGLE NUCLEOTIDE POLYMORPHISMS IN THE DIAGNOSIS OF SCHIZOPHRENIA
US20030044409A1 (en) * 2001-05-01 2003-03-06 Carson Dennis A. Immunologic compositions and methods for studying and treating cancers expressing frizzled antigens
AU2002308557A1 (en) * 2001-05-01 2002-11-11 The Regents Of The University Of California Wnt and frizzled receptors as targets for immunotherapy in head and neck squamous cell carcinomas
US20030017159A1 (en) * 2001-05-02 2003-01-23 Jerome Ritz Immunogenic tumor antigens: nucleic acids and polypeptides encoding the same and methods of use thereof
JP2004535794A (ja) * 2001-05-03 2004-12-02 チルドレンズ・メディカル・センター・コーポレイション 精子特異的カチオンチャネルおよびその使用
US7338805B2 (en) 2001-05-04 2008-03-04 Bio Merieux Labeling reagents, methods for synthesizing such reagents and methods for detecting biological molecules
US7060441B2 (en) * 2001-05-04 2006-06-13 Biomerieux Method for fragmenting and labeling DNA involving abasic sites and phosphate labeling
ATE408710T1 (de) 2001-05-07 2008-10-15 Mayo Foundation Nachweis von legionella durch ein pcr und fret verwendendes verfahren
DE60228477D1 (de) 2001-05-08 2008-10-02 Darwin Molecular Corp Verfahren zur regulierung der immunfunktion in primaten unter verwendung des foxp3-proteins
AU2002311897A1 (en) * 2001-05-09 2002-11-18 Third Wave Technologies, Inc. Nucleic acid detection in pooled samples
CA2446788A1 (en) 2001-05-09 2002-11-14 Corixa Corporation Compositions and methods for the therapy and diagnosis of prostate cancer
WO2002090506A2 (en) 2001-05-09 2002-11-14 Monsanto Technology Llc Metabolite transporters
EP1950305A1 (en) 2001-05-09 2008-07-30 Monsanto Technology, LLC Tyr a genes and uses thereof
US7244853B2 (en) 2001-05-09 2007-07-17 President And Fellows Of Harvard College Dioxanes and uses thereof
EP3000881A3 (en) 2001-05-15 2016-07-20 Novozymes A/S Alpha-amylase variant with altered properties
BR0209154A (pt) 2001-05-18 2004-07-20 Danisco Processo de preparação de uma massa com uma enzima
WO2002095055A2 (en) * 2001-05-21 2002-11-28 Invitrogen Corporation Compositions and methods for use in isolation of nucleic acid molecules
MY140679A (en) * 2001-05-24 2010-01-15 Avanir Pharmaceuticals Inhibitors of macrohage migration inhibitory factor and methods for identifying the same
MXPA03010706A (es) * 2001-05-24 2004-05-27 Cephalon Inc Nuevo polipeptido de quinasa (7) (mlk7) de linaje mezclado polinucleotidos que codifican al mismo y metodos para su uso.
WO2002097123A2 (en) * 2001-05-25 2002-12-05 Xenon Genetics, Inc. Diagnostic methods for cardiovascular disease, low hdl-cholesterol levels, and high triglyceride levels
US20030129607A1 (en) * 2001-05-25 2003-07-10 Invitrogen Corporation Compositions and methods for extension of nucleic acids
AU2002259316A1 (en) 2001-05-30 2002-12-09 The United States Of America, As Represented By The Secretary Of The Navy Protein arrays and methods and systems for producing the same
CA2348042A1 (en) * 2001-06-04 2002-12-04 Ann Huletsky Sequences for detection and identification of methicillin-resistant staphylococcus aureus
JP4242761B2 (ja) 2001-06-06 2009-03-25 ノボザイムス アクティーゼルスカブ エンド−β−１，４−グルカナーゼ
MXPA03011260A (es) * 2001-06-07 2004-02-27 Wyeth Corp Receptor acoplado a proteina g y usos del mismo.
US20020187490A1 (en) * 2001-06-07 2002-12-12 Michigan State University Microbial identification chip based on DNA-DNA hybridization
US7026121B1 (en) * 2001-06-08 2006-04-11 Expression Diagnostics, Inc. Methods and compositions for diagnosing and monitoring transplant rejection
US6905827B2 (en) * 2001-06-08 2005-06-14 Expression Diagnostics, Inc. Methods and compositions for diagnosing or monitoring auto immune and chronic inflammatory diseases
US7235358B2 (en) * 2001-06-08 2007-06-26 Expression Diagnostics, Inc. Methods and compositions for diagnosing and monitoring transplant rejection
US6770622B2 (en) 2001-06-08 2004-08-03 Gary A. Jarvis N-terminally truncated galectin-3 for use in treating cancer
US7291490B2 (en) * 2001-06-11 2007-11-06 Ecopia Biosciences Inc. Nucleic acid fragment encoding an NRPS for the biosynthesis of anthramycin
WO2002101051A2 (en) 2001-06-11 2002-12-19 Ecopia Biosciences Inc. Genes and proteins for the biosynthesis of anthramycin
AU2002311183B2 (en) * 2001-06-12 2007-03-01 Takara Bio Inc. Method of stabilizing reagent for amplifying or detecting nucleic acid and storage method
US20030165895A1 (en) * 2001-06-12 2003-09-04 Bogdan Czerniak Methods of detecting, diagnosing and treating cancer and identifying neoplastic progression
WO2003000932A1 (en) * 2001-06-20 2003-01-03 Dahlia Minc-Golomb Method for identifying genes that are upstream regulators of other genes of interest
DK1402024T3 (da) 2001-06-20 2007-12-27 Nuevolution As Fremgangsmåde til syntese af et template-molekyle
US7491506B2 (en) * 2001-06-21 2009-02-17 The Regents Of The University Of California Inhibition of B-cell maturation and antibody production
CA2451317C (en) 2001-06-26 2016-03-29 Senomyx, Inc. T1r hetero-oligomeric taste receptors and cell lines that express said receptors and use thereof for identification of taste compounds
US8073627B2 (en) 2001-06-26 2011-12-06 Ibis Biosciences, Inc. System for indentification of pathogens
US7217510B2 (en) 2001-06-26 2007-05-15 Isis Pharmaceuticals, Inc. Methods for providing bacterial bioagent characterizing information
US20030096377A1 (en) * 2001-06-28 2003-05-22 Virginia Tech Intellectual Properties, Inc. Differential PCR-RFLP assay for detecting and distinguishing between nonpathogenic PCV-1 and pathogenic PCV-2
CA2450985A1 (en) * 2001-06-28 2003-01-09 Mountain View Pharmaceuticals, Inc. Polymer stabilized proteinases
US9261460B2 (en) 2002-03-12 2016-02-16 Enzo Life Sciences, Inc. Real-time nucleic acid detection processes and compositions
US20040029790A1 (en) * 2001-07-05 2004-02-12 Meera Patturajan Novel human proteins, polynucleotides encoding them and methods of using the same
US20030087274A1 (en) * 2001-07-05 2003-05-08 Anderson David W. Therapeutic polypeptides, nucleic acids encoding same, and methods of use
US7211659B2 (en) 2001-07-05 2007-05-01 Chiron Corporation Polynucleotides encoding antigenic HIV type C polypeptides, polypeptides and uses thereof
CA2453207A1 (en) * 2001-07-06 2003-01-16 454 Corporation Method for isolation of independent, parallel chemical micro-reactions using a porous filter
IL159640A0 (en) 2001-07-10 2004-06-01 Senomyx Inc Use of specific t2r taste receptors to identify compounds that block bitter taste
EP1481076A4 (en) 2001-07-12 2005-05-11 Illumina Inc MULTIPLEX NUCLEIC REACTIONS
US7226732B2 (en) 2001-07-16 2007-06-05 Cepheid Methods, apparatus, and computer programs for verifying the integrity of a probe
US20030082720A1 (en) * 2001-07-17 2003-05-01 Lifton Richard P. Compositions methods and kits relating to treating and diagnosing hypertension
US6884619B2 (en) 2001-07-17 2005-04-26 Yale University Inhibition of BEHAB cleavage and primary central nervous system (CNS) tumors
EP1414838A4 (en) * 2001-07-19 2005-12-14 Yissum Res Dev Co POLYPEPTIDES HAVING CATALYTIC ACTIVITY OF CAROTENOID ISOMERASE, NUCLEIC ACIDS ENCODING THESE POLYPEPTIDES AND APPLICATIONS THEREOF
US6632611B2 (en) * 2001-07-20 2003-10-14 Affymetrix, Inc. Method of target enrichment and amplification
US20030170661A1 (en) * 2001-07-23 2003-09-11 Yi Liu Method for identifying a nucleic acid sequence
US6872529B2 (en) * 2001-07-25 2005-03-29 Affymetrix, Inc. Complexity management of genomic DNA
US7858762B2 (en) 2001-07-30 2010-12-28 Genencor International, Inc. Phosphate limited inducible promoter and a Bacillus expression system
EP1420821B8 (en) 2001-07-31 2011-02-02 University of Washington Immunologically significant herpes simplex virus antigens and methods for using same
ATE481497T1 (de) * 2001-08-01 2010-10-15 Univ Utah Am n-terminus trunkierte isoformen von zyklischen phosphodiesterasen pde3a
US7229774B2 (en) 2001-08-02 2007-06-12 Regents Of The University Of Michigan Expression profile of prostate cancer
US7629153B2 (en) * 2001-08-02 2009-12-08 Research Development Foundation Methods and compositions relating to improved lentiviral vector production systems
US20030027258A1 (en) * 2001-08-02 2003-02-06 Chang Fang-Tseh Frank Methods and compositions for pearl oyster cultivation
US6403341B1 (en) 2001-08-02 2002-06-11 Wayne M. Barnes Magnesium precipitate hot start method for PCR
US20030027196A1 (en) * 2001-08-02 2003-02-06 Barnes Wayne M. Magnesium precipitate methods for magnesium dependent enzymes
US20040006033A1 (en) * 2001-08-06 2004-01-08 Zhu York Yuan-Yuan Methods for identifying low-abundance polynucleotides and related compositions
US20040166491A1 (en) * 2001-08-09 2004-08-26 Henderson Lee A Vhl promoter diagnostic polymorphism
US7809710B2 (en) 2001-08-14 2010-10-05 Quigo Technologies Llc System and method for extracting content for submission to a search engine
IL160396A0 (en) 2001-08-14 2004-07-25 Sentigen Corp Nucleic acids and proteins of insect or83b odorant receptor genes and uses thereof
US20060073530A1 (en) * 2001-08-15 2006-04-06 Olaf Schneewind Methods and compositions involving sortase B
CA2457164A1 (en) 2001-08-17 2003-02-27 Enkam Pharmaceuticals A/S Compounds capable of affecting differentiation, proliferation, regeneration, plasticity and survival of cells
US20080026367A9 (en) * 2001-08-17 2008-01-31 Perlegen Sciences, Inc. Methods for genomic analysis
CA2458127A1 (en) * 2001-08-20 2003-02-27 Takara Bio Inc. Nucleic acid amplification methods
US6995841B2 (en) 2001-08-28 2006-02-07 Rice University Pulsed-multiline excitation for color-blind fluorescence detection
US20030170667A1 (en) * 2001-08-28 2003-09-11 Kaytes Paul S. Single nucleotide polymorphisms diagnostic for schizophrenia
US20040115699A1 (en) * 2001-08-28 2004-06-17 Kaytes Paul S. Single nucleotide polymorphisms diagnostic for schizophrenia
CA2356540A1 (en) * 2001-08-30 2003-02-28 Emory University Expressed dna sequences involved in mitochondrial functions
US7176278B2 (en) 2001-08-30 2007-02-13 Biorexis Technology, Inc. Modified transferrin fusion proteins
US20050032060A1 (en) * 2001-08-31 2005-02-10 Shishir Shah Arrays comprising pre-labeled biological molecules and methods for making and using these arrays
US20050147984A1 (en) * 2001-08-31 2005-07-07 Clondiag Chip Technologies Gmbh Interaction detection on several probe arrays
US20120077196A9 (en) * 2001-09-03 2012-03-29 Guido Krupp Universal method for selective amplification of mRNAs
DE10143106C1 (de) * 2001-09-03 2002-10-10 Artus Ges Fuer Molekularbiolog Vermehrung von Ribonukleinsäuren
US6852491B2 (en) 2001-09-04 2005-02-08 Abbott Laboratories Amplification and detection reagents for HIV-1
US6898531B2 (en) 2001-09-05 2005-05-24 Perlegen Sciences, Inc. Algorithms for selection of primer pairs
US6740510B2 (en) 2001-09-05 2004-05-25 Perlegen Sciences, Inc. Methods for amplification of nucleic acids
US20030054396A1 (en) * 2001-09-07 2003-03-20 Weiner Michael P. Enzymatic light amplification
US20040191774A1 (en) * 2001-09-11 2004-09-30 Moskowitz David W Endothelin-1 promoter polymorphism
US6974671B1 (en) 2001-09-12 2005-12-13 Salk Institute For Biological Studies Methods for indentifying compounds that modulate gluconeogenesis through the binding of CREB to the PGC-1 promoter
WO2003023014A2 (en) * 2001-09-12 2003-03-20 Pharmacia & Upjohn Company Human ion channels
FR2829774B1 (fr) 2001-09-14 2004-09-03 Pasteur Institut N-desoxyribosyltransferases de lactobacilles, sequences nucleotidiques correspondantes et leurs applications
US20060068405A1 (en) * 2004-01-27 2006-03-30 Alex Diber Methods and systems for annotating biomolecular sequences
US20050042629A1 (en) 2002-09-13 2005-02-24 Applera Corporation Thermus scotoductus nucleic acid polymerases
US20040142325A1 (en) 2001-09-14 2004-07-22 Liat Mintz Methods and systems for annotating biomolecular sequences
EP1436385A4 (en) * 2001-09-14 2005-12-14 Invitrogen Corp DNA POLYMERASES AND MUTANTS CORRESPONDING
AU2005243741B2 (en) * 2001-09-18 2010-01-28 Bioexpertise Llc Methods for delivering MBD peptide- linked agent into cells under conditions of cellular stress
US20060188875A1 (en) * 2001-09-18 2006-08-24 Perlegen Sciences, Inc. Human genomic polymorphisms
JP2005532780A (ja) 2001-09-19 2005-11-04 インタージェネティックス インコーポレイテッド 発癌リスク層別化のための遺伝的解析
EP1435977A4 (en) * 2001-09-19 2005-06-08 Ford Henry Health System HEART TRANSPLANTATION OF STEM CELLS FOR THE TREATMENT OF HEART FAILURE
EP1908851A3 (en) 2001-09-19 2008-06-25 Intergenetics Incorporated Genetic analysis for stratification of cancer risk
JP4439262B2 (ja) 2001-09-19 2010-03-24 アレクシオン ファーマシューティカルズ， インコーポレイテッド 操作されたテンプレートおよび単一プライマー増幅におけるそれらの使用
US7414111B2 (en) 2001-09-19 2008-08-19 Alexion Pharmaceuticals, Inc. Engineered templates and their use in single primer amplification
US6846631B2 (en) * 2001-09-24 2005-01-25 Syngenta Participations Ag Detection of Fusarium species infecting corn using the polymerase chain reaction
US8512953B2 (en) 2001-09-24 2013-08-20 One Lambda Diagnostic probe detection system
US7202028B2 (en) * 2001-09-24 2007-04-10 The University Of North Carolina At Chapel Hill Methods for the electrochemical detection of multiple target compounds
US6852492B2 (en) * 2001-09-24 2005-02-08 Intel Corporation Nucleic acid sequencing by raman monitoring of uptake of precursors during molecular replication
US7238477B2 (en) * 2001-09-24 2007-07-03 Intel Corporation Methods to increase nucleotide signals by Raman scattering
US6972173B2 (en) * 2002-03-14 2005-12-06 Intel Corporation Methods to increase nucleotide signals by raman scattering
BR0212818A (pt) 2001-09-27 2004-10-05 Novo Nordisk Healthcare Ag Polipeptìdeo de fator vii, construção de polionucletìdeo, célula hospedeira, animal transgênico, planta transgênica, método para produzir o polipeptìdeo de fator vii composição farmacêutica, uso de um polipeptìdeo de fator vii, e, método para o tratamento de distúrbios do sangramento em um sujeito ou para o aprimoramento do sistema hemostático normal
EP1961293A3 (en) 2001-09-27 2009-01-28 Pioneer Hi-Bred International, Inc. Phytate polynucleotides and methods of use
US6902914B2 (en) * 2001-09-28 2005-06-07 Sigma-Aldrich, Co. Recombinant DNA processes using a dNTP mixture containing modified nucleotides
US20040106109A1 (en) * 2001-10-02 2004-06-03 Belly Robert T Detection of ras mutations
KR20040054699A (ko) 2001-10-02 2004-06-25 엥스띠뛰 끌레이톤 드 라 러쉐르쉬 제한된 발현의 렌티바이러스 벡터 및 이의 적용과 관련된방법 및 조성물
US20040053232A1 (en) * 2001-10-05 2004-03-18 Perlegen Sciences, Inc. Haplotype structures of chromosome 21
GB0123856D0 (en) * 2001-10-05 2001-11-28 Amersham Pharm Biotech Uk Ltd Method for determining cell cycle position
WO2003031591A2 (en) * 2001-10-10 2003-04-17 Superarray Bioscience Corporation Detecting targets by unique identifier nucleotide tags
ES2606840T3 (es) 2001-10-10 2017-03-28 Ratiopharm Gmbh Remodelación y glicoconjugación de factor estimulante de colonias de granulocitos (G-CSF)
DK2279755T3 (da) 2001-10-10 2014-05-26 Ratiopharm Gmbh Remodellering og glycokonjugering af fibroblastvækstfaktor (FGF)
DK1434482T3 (da) * 2001-10-11 2006-08-14 Marical Inc Fremgangsmåder til dyrkning og prægning af fisk ved anvendelse af et lugtstof
US20040014067A1 (en) * 2001-10-12 2004-01-22 Third Wave Technologies, Inc. Amplification methods and compositions
US7439346B2 (en) 2001-10-12 2008-10-21 Perkinelmer Las Inc. Nucleic acids arrays and methods of use therefor
JP2005522187A (ja) * 2001-10-12 2005-07-28 ザ レジェンツ オブ ザ ユニバーシティー オブ カリフォルニア サン ディエゴ 胃腸化学感覚受容体
AU2002367886B8 (en) 2001-10-12 2008-08-14 Perkinelmer Las, Inc. Compilations of nucleic acids and arrays and methods of using them
US20030082563A1 (en) * 2001-10-15 2003-05-01 Bell Constance A. Detection of bacillus anthracis
HUP0501111A2 (en) * 2001-10-15 2007-12-28 Chiron Corp Treatment of severe pneumonia by administration of tissue factor pathway inhibitor
US7297485B2 (en) * 2001-10-15 2007-11-20 Qiagen Gmbh Method for nucleic acid amplification that results in low amplification bias
JP4173446B2 (ja) 2001-10-19 2008-10-29 ヴァスキュラー バイオジェニックス リミテッド 血管形成の標的化されたダウンレギュレーションおよび抗ガン治療のためのポリヌクレオチド構築物および薬学的組成物および方法
US8729248B2 (en) * 2001-10-22 2014-05-20 Children's Medical Center Corporation Sperm-specific cation channel, CATSPER2, and uses therefor
US20030165859A1 (en) * 2001-10-23 2003-09-04 Invitrogen Corporation Primers and methods for the detection and discrimination of nucleic acids
US20040126762A1 (en) * 2002-12-17 2004-07-01 Morris David W. Novel compositions and methods in cancer
US20040166490A1 (en) * 2002-12-17 2004-08-26 Morris David W. Novel therapeutic targets in cancer
US20030124592A1 (en) * 2001-10-24 2003-07-03 Bioprofile, Llc Methods for detecting genetic haplotypes by interaction with probes
US6942972B2 (en) 2001-10-24 2005-09-13 Beckman Coulter, Inc. Efficient synthesis of protein-oligonucleotide conjugates
AU2002334950A1 (en) * 2001-10-26 2003-05-12 Genencor International, Inc. T. reesei phytase enzymes, polynucleides encoding the enzymes, vectors and host cells thereof, and methods of using
AU2002356855A1 (en) 2001-10-26 2003-05-12 Genencor International, Inc. Phytase enzymes, nucleic acid sequences encoding phytase enzymes and vectors and host cells incorporating same
US20050124022A1 (en) * 2001-10-30 2005-06-09 Maithreyan Srinivasan Novel sulfurylase-luciferase fusion proteins and thermostable sulfurylase
WO2003038127A1 (en) * 2001-10-30 2003-05-08 Ahram Biosystems Inc. Method and apparatus for amplification of nucleic acid sequences using immobilized dna polymerase
US6956114B2 (en) 2001-10-30 2005-10-18 '454 Corporation Sulfurylase-luciferase fusion proteins and thermostable sulfurylase
US6902921B2 (en) 2001-10-30 2005-06-07 454 Corporation Sulfurylase-luciferase fusion proteins and thermostable sulfurylase
AU2002343607A1 (en) * 2001-11-01 2003-05-12 The Penn State Research Foundation Enzymatic manipulation of metal particle-bound dna
WO2003040690A2 (en) 2001-11-02 2003-05-15 Rice University Recycling system for manipulation of intracellular nadh availability
US20040029105A1 (en) * 2001-11-02 2004-02-12 Smith Thomas F. Detection of variola virus
US20030119000A1 (en) * 2001-11-05 2003-06-26 Jon Polansky Methods to screen and treat individuals with glaucoma or the propensity to develop glaucoma
MXPA04004291A (es) * 2001-11-09 2004-08-11 Upjohn Co Polimorfismos de un unico nucleotido en la gh-1.
AU2002364894A1 (en) * 2001-11-09 2003-06-30 Neurogenetics, Inc. Single nucleotide polymorphisms and mutations on alpha-2-macroglobulin
US20040067512A1 (en) * 2001-11-09 2004-04-08 Neurogenetics, Inc. Single nucleotide polymorphisms and mutations on Alpha-2-Macroglobulin
US7222059B2 (en) 2001-11-15 2007-05-22 Siemens Medical Solutions Diagnostics Electrophoretic trace simulator
US7166463B2 (en) 2001-11-16 2007-01-23 The Regents Of The University Of Colorado Nucleic acids encoding modified olfactory cyclic nucleotide gated ion channels
KR101019131B1 (ko) * 2001-11-19 2011-03-07 인터레우킨 제네틱스, 인코포레이티드 염증성 질환 및 감염성 질환에 대한 감수성 및 전사에영향을 미치는 인터루킨-1 좌의 기능적 다형성
US20080311581A1 (en) * 2001-11-19 2008-12-18 David Wyllie Functional polymorphisms of the interleukin-1 locus affecting transcription and susceptibility to inflammatory and infectious diseases
US6696254B2 (en) 2001-11-21 2004-02-24 Kimberly-Clark Worldwide, Inc. Detection and identification of enteric bacteria
US7635588B2 (en) * 2001-11-29 2009-12-22 Applied Biosystems, Llc Apparatus and method for differentiating multiple fluorescence signals by excitation wavelength
US20040197778A1 (en) * 2002-12-26 2004-10-07 Sagres Discovery, Inc. Novel compositions and methods in cancer
US20060040262A1 (en) * 2002-12-27 2006-02-23 Morris David W Novel compositions and methods in cancer
US20040180344A1 (en) * 2003-03-14 2004-09-16 Morris David W. Novel therapeutic targets in cancer
US7052877B2 (en) 2001-11-30 2006-05-30 Applera Corporation Thermus brockianus nucleic acid polymerases
JP2005511043A (ja) 2001-11-30 2005-04-28 アプレラ コーポレイション Ｔｈｅｒｍｕｓｔｈｅｒｍｏｐｈｉｌｕｓ核酸ポリメラーゼ
US6635428B2 (en) * 2001-12-04 2003-10-21 Quest Diagnostics Investments Incorporated Oligonucleotides and methods for detecting hepatitis B viral nucleic acids
AU2002358947A1 (en) * 2001-12-05 2003-06-17 Yissum Research Development Company Of The Hebrew University Of Jerusalem Nanoparticles containing polymeric nucleic acid homologs, pharmaceutical compositions and articles of manufacture containing same and methods of use thereof
CN1630514A (zh) 2001-12-05 2005-06-22 贝勒医学院 通过调节交感神经紧张性控制骨形成的方法和组合物
AU2002351332A1 (en) * 2001-12-07 2003-06-23 Chiron Corporation Endogenous retrovirus polypeptides linked to oncogenic transformation
US20060275747A1 (en) * 2001-12-07 2006-12-07 Hardy Stephen F Endogenous retrovirus up-regulated in prostate cancer
US20030175749A1 (en) * 2001-12-08 2003-09-18 Jong-Yoon Chun Annealing control primer and its uses
BRPI0214821B8 (pt) * 2001-12-10 2021-07-27 Novartis Ag método para determinar a responsividade de indivíduo com distúrbio psicótico ao tratamento com loperidona
EP1465654B1 (en) 2001-12-11 2015-02-25 Inovio Pharmaceuticals, Inc. Plasmid mediated supplementation for treating chronically ill subjects
EP2335724A1 (en) 2001-12-12 2011-06-22 Novartis Vaccines and Diagnostics S.r.l. Immunisation against chlamydia trachomatis
US20030148462A1 (en) * 2001-12-14 2003-08-07 President And Fellows Of Harvard College Dual inhibition of sister chromatid separation at metaphase
CA2476755C (en) 2001-12-17 2014-08-26 Corixa Corporation Compositions and methods for the therapy and diagnosis of inflammatory bowel disease
ES2337989T3 (es) * 2001-12-18 2010-05-03 Endocube Sas Nuevas proteinas asociadas a la muerte de la familia thap y rutas par4 relacionadas implicadas en el control de la apoptosis.
US20040126829A1 (en) * 2001-12-18 2004-07-01 Hildebrand William H. Anti-HLA assay and methods
KR100446621B1 (ko) * 2001-12-18 2004-09-07 삼성전자주식회사 다중 중합효소 연쇄반응에 의한 ｍｏｄｙ３유전자의 증폭을 위한 프라이머 세트
US7858297B2 (en) 2001-12-18 2010-12-28 Centre National De La Recherche Scientifique Cnrs Chemokine-binding protein and methods of use
CA2467383C (en) * 2001-12-19 2012-08-28 The University Of Chicago Rapidly maturing fluorescent proteins and methods for using the same
EP1455815A4 (en) * 2001-12-19 2006-11-02 Millennium Pharm Inc MEMBERS OF THE DIACYLGLYCEROL-ACYLTRANSFERASES FAMILY 2 (DGAT2) AND USES THEREOF
US20030180741A1 (en) 2001-12-21 2003-09-25 Holly Hogrefe High fidelity DNA polymerase compositions and uses therefor
US20050106568A1 (en) * 2001-12-28 2005-05-19 Makoto Kobayashi Method of quantifying nucleic acid and kit for quantifying nucleic acid
US20050118688A1 (en) * 2001-12-28 2005-06-02 Hudson Freeze Novel ligand involved in the transmigration of leukocytes across the endothelium and uses therefor
US6578724B1 (en) * 2001-12-29 2003-06-17 United States Can Company Connector for use in packaging aerosol containers
US7135174B2 (en) * 2002-01-07 2006-11-14 Amgen Fremont, Inc. Antibodies directed to PDGFD and uses thereof
US20050064423A1 (en) * 2002-01-08 2005-03-24 Toshiro Higuchi Pcr method by electrostatic transportation, hybridization method for electrostatic transportation and devices therefor
US7373968B2 (en) * 2002-01-08 2008-05-20 Kevin R. Oldenburg Method and apparatus for manipulating an organic liquid sample
US7614444B2 (en) 2002-01-08 2009-11-10 Oldenburg Kevin R Rapid thermal cycling device
FR2834521B1 (fr) * 2002-01-10 2004-12-17 Bio Merieux Procede de detection et/ou d'identification de l'espece animale d'origine de la matiere animale contenue dans un echantillon
US6900017B2 (en) * 2002-01-10 2005-05-31 The Board Of Trustees Of The University Of Illinois Human hematopoietic growth regulatory gene and uses
WO2003057179A2 (en) 2002-01-11 2003-07-17 Biomarin Pharmaceutical, Inc. Use of p97 as an enzyme delivery system for the delivery of therapeutic lysosomal enzymes
ES2351678T3 (es) 2002-01-18 2011-02-09 Zymogenetics, Inc. Ligando de citocina para el tratamiento de asma e hiper-sensibilidad de las vías respiratorias .
EP2840089A1 (en) 2002-01-18 2015-02-25 ZymoGenetics, Inc. Cytokine receptor zcytor17 multimers
US7125478B2 (en) * 2002-01-18 2006-10-24 The Regents Of The University Of Michigan Microscale electrophoresis devices for biomolecule separation and detection
IL152904A0 (en) * 2002-01-24 2003-06-24 Gamida Cell Ltd Utilization of retinoid and vitamin d receptor antagonists for expansion of renewable stem cell populations
WO2003062404A1 (en) 2002-01-25 2003-07-31 Gamida-Cell Ltd. Methods of expanding stem and progenitor cells and expanded cell populations obtained thereby
US20070264645A1 (en) * 2002-01-25 2007-11-15 Kenneth Kornman IL-1 gene cluster and associated inflammatory polymorphisms and haplotypes
US20040116668A1 (en) * 2002-01-29 2004-06-17 Robert Day Zis-sr nucleic acid and amino acid sequences involved in the regulated secretory pathway and/or the regulation of the neuroendocrine phenotype (nep)
US7211656B2 (en) * 2002-01-30 2007-05-01 Abbott Laboratories Desaturase genes, enzymes encoded thereby, and uses thereof
US20040096826A1 (en) * 2002-01-30 2004-05-20 Evans Glen A. Methods for creating recombination products between nucleotide sequences
US7255986B2 (en) * 2002-01-31 2007-08-14 The Board Of Trustees Operating Michigan State University Compositions for the diagnosis and treatment of epizootic catarrhal enteritis in ferrets
US20040052928A1 (en) * 2002-09-06 2004-03-18 Ehud Gazit Peptides and methods using same for diagnosing and treating amyloid-associated diseases
US7781396B2 (en) * 2002-01-31 2010-08-24 Tel Aviv University Future Technology Development L.P. Peptides directed for diagnosis and treatment of amyloid-associated disease
EP2213737B1 (en) 2002-02-01 2012-11-07 Life Technologies Corporation Double-stranded oligonucleotides
US20040053264A1 (en) * 2002-02-01 2004-03-18 Park Sung Sup Clinical panel assay using DNA chips
US20060009409A1 (en) 2002-02-01 2006-01-12 Woolf Tod M Double-stranded oligonucleotides
US20030166282A1 (en) 2002-02-01 2003-09-04 David Brown High potency siRNAS for reducing the expression of target genes
US20040166492A1 (en) * 2002-02-05 2004-08-26 Engel Stacia R. Quantitative detection of dekkera and saccharomyces
WO2003066836A2 (en) * 2002-02-07 2003-08-14 E. I. Du Pont De Nemours And Company Udp-glucosyltransferases
US6992176B2 (en) 2002-02-13 2006-01-31 Technion Research & Development Foundation Ltd. Antibody having a T-cell receptor-like specificity, yet higher affinity, and the use of same in the detection and treatment of cancer, viral infection and autoimmune disease
WO2003071252A2 (en) 2002-02-15 2003-08-28 Exact Sciences Corporation Methods for analysis of molecular events
AU2003217421A1 (en) * 2002-02-19 2003-09-09 Idec Pharmaceuticals Corporation Prostate specific genes and the use thereof in design or therapeutics
US6593093B1 (en) 2002-02-20 2003-07-15 Mayo Foundation For Medical Education And Research Detection of group a Streptococcus
US7354742B2 (en) 2002-02-22 2008-04-08 Ortho-Mcneil Pharmaceutical, Inc. Method for generating amplified RNA
EP1485712A2 (en) * 2002-02-26 2004-12-15 Pharmacia Corporation Sequence detection system calculator
DK2315145T3 (en) 2002-03-01 2016-01-25 Codexis Mayflower Holdings Llc Methods, systems, and software for identifying the functional biomolecules
JP2006523082A (ja) * 2002-03-01 2006-10-12 ラブジェン， インコーポレイテッド ゲノム内の変異の迅速分析
US6977162B2 (en) * 2002-03-01 2005-12-20 Ravgen, Inc. Rapid analysis of variations in a genome
US20040043959A1 (en) * 2002-03-04 2004-03-04 Bloom Laura A. Combination therapies for treating methylthioadenosine phosphorylase deficient cells
ES2253461T3 (es) * 2002-03-05 2006-06-01 Epigenomics Ag Procedimiento y dispositivo para la determinacion de la especificidad del tejido y del adn que flota libre en tejidos corporales.
US7179639B2 (en) * 2002-03-05 2007-02-20 Raveendran Pottathil Thermal strip thermocycler
CA2477780A1 (en) * 2002-03-05 2003-09-18 Board Of Regents, The University Of Texas System Methods of enhancing immune induction involving mda-7
GB0205455D0 (en) 2002-03-07 2002-04-24 Molecular Sensing Plc Nucleic acid probes, their synthesis and use
US7620500B2 (en) 2002-03-09 2009-11-17 Maxygen, Inc. Optimization of crossover points for directed evolution
ATE556084T1 (de) 2002-03-11 2012-05-15 Lab 21 Ltd Verfahren und zusammensetzungen zur identifizierung und charakterisierung von hepatitis c
US7166478B2 (en) * 2002-03-12 2007-01-23 Enzo Life Sciences, Inc., C/O Enzo Biochem, Inc. Labeling reagents and labeled targets, target labeling processes and other processes for using same in nucleic acid determinations and analyses
US9353405B2 (en) 2002-03-12 2016-05-31 Enzo Life Sciences, Inc. Optimized real time nucleic acid detection processes
US20030228596A1 (en) * 2002-03-14 2003-12-11 Qiang Liu Template-driven nucleic acid amplifications
HUP0200981A3 (en) * 2002-03-14 2004-06-28 Genoid Kft Pcr reactions with hybridizing probes using primers with broad genotype-specificity for detection of human papilloma-viruses and typing amplificates by using specifically hybridizing oligonucleotides
US20040241723A1 (en) * 2002-03-18 2004-12-02 Marquess Foley Leigh Shaw Systems and methods for improving protein and milk production of dairy herds
EP1485464A4 (en) * 2002-03-18 2006-11-29 Gamida Cell Ltd METHODS OF INDUCING DIFFERENTIATION IN EX VIVO EXPANDED STEM CELLS
US7897842B2 (en) 2002-03-19 2011-03-01 Plant Research International B.V. GnTIII expression in plants
US20040023267A1 (en) * 2002-03-21 2004-02-05 Morris David W. Novel compositions and methods in cancer
US20040110208A1 (en) * 2002-03-26 2004-06-10 Selena Chan Methods and device for DNA sequencing using surface enhanced Raman scattering (SERS)
US7476501B2 (en) * 2002-03-26 2009-01-13 Intel Corporation Methods and device for DNA sequencing using surface enhanced raman scattering (SERS)
EP1578354A4 (en) 2002-03-26 2008-04-09 Massachusetts Inst Technology TARGETS, METHODS AND REAGENTS FOR THE DIAGNOSIS AND TREATMENT OF SCHIZOPHRENIA
US6916621B2 (en) * 2002-03-27 2005-07-12 Spectral Genomics, Inc. Methods for array-based comparitive binding assays
US20030186246A1 (en) * 2002-03-28 2003-10-02 Willey James C. Multiplex standardized reverse transcriptase-polymerase chain reacton method for assessment of gene expression in small biological samples
DK1495128T3 (da) * 2002-03-29 2014-08-11 Genencor Int Forstærket proteinekspression i Bacillus
EP2275126A3 (en) 2002-04-02 2011-04-27 Ben-Gurion University Of The Negev Research And Development Authority Protein-based streptococcus pneumoniae vaccines
US7148049B2 (en) 2002-04-02 2006-12-12 Roche Molecular Systems, Inc. Thermostable or thermoactive DNA polymerase molecules with attenuated 3′-5′ exonuclease activity
US7052840B2 (en) * 2002-04-03 2006-05-30 Capitol Genomix, Inc. Reversible association of nucleic acid with a carboxylated substrate
AU2003239129A1 (en) * 2002-04-12 2003-10-27 New England Biolabs, Inc. Methods and compositions for dna manipulation
US7452535B2 (en) * 2002-04-12 2008-11-18 Medarex, Inc. Methods of treatment using CTLA-4 antibodies
US7563567B1 (en) 2002-04-12 2009-07-21 The Curators of the Univeristy of Missouri of Columbia Use of ECIST microarrays in an integrated method for assessing DNA methylation, gene expression and histone acetylation
EP1497434A4 (en) * 2002-04-15 2005-08-24 Merck & Co Inc MATRIX ANALYSIS OF GENE EXPRESSION IN CELLS
US7026120B2 (en) 2002-04-15 2006-04-11 Abbott Laboratories Probes for detecting tumor cells
CN101676728A (zh) 2002-04-19 2010-03-24 津莫吉尼蒂克斯公司 细胞因子受体
BR0309391A (pt) 2002-04-19 2005-10-25 Diversa Corp Fosfolipases, ácidos nucléicos codificando-as e métodos para preparar e usá-las
DK1499733T3 (da) 2002-04-22 2010-07-12 Novozymes Inc Fremgangsmåder til fremstilling af varianter af en DNA-sekvens i trådformige svampe
DE60322210D1 (de) * 2002-04-22 2008-08-28 Genencor Int Verfahren zur erzeugung einer bibliothek aus bakterienklonen mit unterschiedlichen genexpressionsniveaus
US20080076678A1 (en) * 2005-06-15 2008-03-27 Philippe Soucaille Method of creating a library of bacterial clones with varying levels of gene expression
AU2003226598A1 (en) * 2002-04-26 2003-11-10 Institut Clayton De La Recherche Improved chimeric glycoproteins and pseudotyped lentiviral vectors
US8257967B2 (en) 2002-04-26 2012-09-04 Board Of Regents, The University Of Texas System Method and system for the detection of cardiac risk factors
EP1578772B1 (en) * 2002-05-01 2010-05-12 Danisco US Inc. Cytokines and cytokine receptors with reduced immunogenicity
AU2003228751A1 (en) 2002-05-01 2003-11-17 Cell Genesys, Inc. Lentiviral vector particles resistant to complement inactivation
EP2216405A1 (en) 2002-05-03 2010-08-11 Monsanto Technology LLC Speed specific USP promoters for expressing genes in plants
US20040121442A1 (en) * 2002-05-05 2004-06-24 Ilan Chet Fungal chitinase, polynucleotide sequences encoding same, promoters of same, and uses thereof
WO2003093303A1 (en) 2002-05-06 2003-11-13 Board Of Regents, The University Of Texas System Targeting proteins to deliver therapeutic or diagnostic reagents
US7579147B2 (en) 2002-05-07 2009-08-25 Wake Forest University Health Sciences Mutations in the macrophage scavenger receptor 1 gene alter risk of prostate cancer, asthma, and cardiovascular disease
US20070178478A1 (en) * 2002-05-08 2007-08-02 Dhallan Ravinder S Methods for detection of genetic disorders
US7727720B2 (en) * 2002-05-08 2010-06-01 Ravgen, Inc. Methods for detection of genetic disorders
US7442506B2 (en) * 2002-05-08 2008-10-28 Ravgen, Inc. Methods for detection of genetic disorders
IL149562A0 (en) 2002-05-09 2002-11-10 Prochon Ltd Fgf variants and methods for use thereof
US7825227B2 (en) * 2002-05-09 2010-11-02 Prolexys Pharmaceuticals, Inc. Method for purification of a protein complex and identification of its components
US20030210489A1 (en) * 2002-05-13 2003-11-13 Yec Co., Ltd. Data eraser and data erasing program
WO2003096797A2 (en) 2002-05-15 2003-11-27 Monsanto Technology Llc Method of increasing plant organ and seed size in a plant
ES2285118T5 (es) * 2002-05-17 2012-09-21 Alligator Bioscience Ab Un método para el desarrollo molecular in vitro de una función proteica.
EP3312594B1 (en) 2002-05-17 2019-07-24 Life Technologies Corporation Apparatus for differentiating multiple fluorescence signals by excitation wavelength
US20030215814A1 (en) * 2002-05-17 2003-11-20 Cockerill Franklin R. Detection of Shiga toxin- or Shiga-like toxin-producing organisms
CN1653338A (zh) 2002-05-17 2005-08-10 贝克顿·迪金森公司 用于分离、放大和检测目标核酸序列的自动化系统
US20030215816A1 (en) * 2002-05-20 2003-11-20 Narayan Sundararajan Method for sequencing nucleic acids by observing the uptake of nucleotides modified with bulky groups
EP1365034A3 (en) 2002-05-21 2004-02-18 Bayer HealthCare AG Methods and compositions for the prediction, diagnosis, prognosis, prevention and treatment of malignant neoplasia
US7033769B2 (en) 2002-05-23 2006-04-25 The United States Of America As Represented By The Secretary Of The Army Method for discovering one or more peptides adapted for specific binding to a microorganism of interest
IL149820A0 (en) 2002-05-23 2002-11-10 Curetech Ltd Humanized immunomodulatory monoclonal antibodies for the treatment of neoplastic disease or immunodeficiency
US20030219754A1 (en) * 2002-05-23 2003-11-27 Oleksy Jerome E. Fluorescence polarization detection of nucleic acids
US20040072208A1 (en) * 2002-05-23 2004-04-15 Peter Warthoe Surface acoustic wave sensors and method for detecting target analytes
US20030219755A1 (en) * 2002-05-24 2003-11-27 Nanibhushan Dattagupta Compositions and methods for performing hybridization assays using target enhanced signal amplification (TESA)
AU2003240795A1 (en) * 2002-05-24 2003-12-12 Invitrogen Corporation Nested pcr employing degradable primers
US7291460B2 (en) * 2002-05-31 2007-11-06 Verenium Corporation Multiplexed systems for nucleic acid sequencing
DE10224200C1 (de) * 2002-05-31 2003-08-21 Artus Ges Fuer Molekularbiolog Vermehrung von Ribonukleinsäuren
US7700571B2 (en) 2002-06-05 2010-04-20 Genentech, Inc. Compositions and methods for liver growth and liver protection
US20040248094A1 (en) * 2002-06-12 2004-12-09 Ford Lance P. Methods and compositions relating to labeled RNA molecules that reduce gene expression
WO2003106630A2 (en) * 2002-06-12 2003-12-24 Ambion, Inc. Methods and compositions relating to polypeptides with rnase iii domains that mediate rna interference
AU2003231912A1 (en) * 2002-06-12 2003-12-31 Tel Aviv Medical Center Research Development Fund Methods of detecting and treating prostate cancer
AU2003276679A1 (en) * 2002-06-13 2003-12-31 Chiron Corporation Vectors for expression of hml-2 polypeptides
AU2003243545A1 (en) * 2002-06-14 2003-12-31 Amylin Pharmaceuticals, Inc. Prevention and/or treatment of inflammatory bowel disease using pyy or agonists thereof
US8178294B2 (en) * 2002-06-14 2012-05-15 Cedars-Sinai Medical Center Method of haplotype-based genetic analysis for determining risk for developing insulin resistance, coronary artery disease and other phenotypes
US7585501B2 (en) 2002-06-14 2009-09-08 Stowers Institute For Medical Research Compositions and methods for treating kidney disease
WO2003106652A2 (en) * 2002-06-14 2003-12-24 Cedars-Sinai Medical Center Method of haplotype-based genetic analysis for determining risk for developing insulin resistance, coronary artery disease and other phenotypes
BR0312121A (pt) 2002-06-14 2007-04-03 Diversa Corp xinalases, ácidos nucléicos codificando-as e métodos para preparar e empregá-las
US7667099B2 (en) * 2002-06-20 2010-02-23 Board Of Trustees Of Michigan State University Plastid division and related genes and proteins, and methods of use
EP1522853A4 (en) * 2002-06-24 2005-10-19 Canon Kk DNA MICROARRAY WITH STANDARD PROBE AND KIT CONTAINING THE MICROARRAY
ATE489477T1 (de) 2002-06-28 2010-12-15 Primeradx Inc Verfahren zum nachweis von sequenzunterschieden
US9321832B2 (en) 2002-06-28 2016-04-26 Domantis Limited Ligand
ES2311731T3 (es) 2002-06-28 2009-02-16 Dow Agrosciences Llc Proteinas de accion pesticida y polinucleotidos que se pueden obtener a partir de especies de paenibacillus.
AU2003256460A1 (en) * 2002-07-01 2004-01-19 Virologic, Inc. Compositions and methods for determining the susceptibility of a pathogenic virus to protease inhibitors
WO2004003144A2 (en) * 2002-07-01 2004-01-08 Human Genome Sciences, Inc. Antibodies that specifically bind to reg iv
JP4013671B2 (ja) * 2002-07-05 2007-11-28 松下電器産業株式会社 ポリメラーゼ連鎖反応容器及びその製造方法
US20040009574A1 (en) * 2002-07-09 2004-01-15 Nanibhushan Dattagupta Compositions and methods for detecting streptococcus agalactiae capsular polysaccharide synthesis genes
US20040009482A1 (en) * 2002-07-09 2004-01-15 Nanibhushan Dattagupta Compositions and methods for detecting streptococcus agalactiae surface immunogenic protein genes
KR100442832B1 (ko) * 2002-07-10 2004-08-02 삼성전자주식회사 다중 중합효소 연쇄반응에 의한 ｍｏｄｙ２ 유전자의증폭을 위한 프라이머 세트
JP2005533102A (ja) * 2002-07-12 2005-11-04 イッサム リサーチ ディベロップメント カンパニー オブ ザ ヘブリュー ユニバーシティー オブ エルサレム 微小器官によって生物学的プロセスを誘発する方法と装置
ATE497774T1 (de) 2002-07-15 2011-02-15 Univ Texas Screening kombinatorischer proteinbibliotheken mittels periplasmatischer expression
US20040204953A1 (en) * 2002-07-17 2004-10-14 Lincoln Muir Subscription based systems, methods and components for providing genomic and proteomic products and services
US20040091945A1 (en) * 2002-07-17 2004-05-13 Cheryl Fitzer-Attas Peptides and methods of screening immunogenic peptide vaccines against Alzheimer's Disease
ATE414176T1 (de) 2002-07-18 2008-11-15 Univ Washington Schnelle, effiziente reinigung von hsv- spezifischen t-lymphozyten und damit identifizierte hsv-antigene
CA2851035C (en) 2002-07-18 2018-05-29 Stanislaw Flasinski Methods for using artificial polynucleotides and compositions thereof to reduce transgene silencing
US20060264610A1 (en) * 2002-07-19 2006-11-23 Cellzome Ag Protein complexes of the tip60 transcriptional activator protein
AU2003254128A1 (en) * 2002-07-19 2004-02-09 Arizona Board Of Regents A high resolution typing system for pathogenic mycobacterium tuberculosum
US7057087B2 (en) 2002-07-26 2006-06-06 Board Of Control Of Michigan Technological University Application of aspen MADS-box genes to alter reproduction and development in trees
US6933377B2 (en) * 2002-07-29 2005-08-23 Qun Chen Compositions comprising multiple immunodeficiency virus subunits for inducing an immune response
EP2385137A1 (en) 2002-07-31 2011-11-09 University of Southern California Polymorphisms for predicting disease and treatment outcome
DK2283724T3 (en) 2002-08-01 2016-04-04 Xy Llc Heterospermic insemination to assess sperm function
EP2436774A3 (en) 2002-08-01 2012-06-13 The Regents of The University of California Therapeutic monoclonal antibodies that neutralize botulinum neurotoxins
US8486618B2 (en) 2002-08-01 2013-07-16 Xy, Llc Heterogeneous inseminate system
ES2449115T3 (es) 2002-08-01 2014-03-18 Yeda Research And Development Co., Ltd. Método y composición para proteger el tejido neuronal de lesiones inducidas por niveles de glutamato elevados
US20040078852A1 (en) * 2002-08-02 2004-04-22 Thomashow Michael F. Transcription factors to improve plant stress tolerance
EP1546392A4 (en) 2002-08-02 2006-05-24 Stratatech Corp DETECTION OF SPECIFIC DNA FROM SPECIES
US20050255086A1 (en) * 2002-08-05 2005-11-17 Davidson Beverly L Nucleic acid silencing of Huntington's Disease gene
US20040023390A1 (en) * 2002-08-05 2004-02-05 Davidson Beverly L. SiRNA-mediated gene silencing with viral vectors
US20080274989A1 (en) 2002-08-05 2008-11-06 University Of Iowa Research Foundation Rna Interference Suppression of Neurodegenerative Diseases and Methods of Use Thereof
US20040241854A1 (en) 2002-08-05 2004-12-02 Davidson Beverly L. siRNA-mediated gene silencing
US20050106731A1 (en) * 2002-08-05 2005-05-19 Davidson Beverly L. siRNA-mediated gene silencing with viral vectors
US20050042646A1 (en) * 2002-08-05 2005-02-24 Davidson Beverly L. RNA interference suppresion of neurodegenerative diseases and methods of use thereof
WO2004013305A2 (en) 2002-08-05 2004-02-12 Quanta Biosciences, Inc. Improved compositions for in vitro amplification of nucleic acids
BR0313281A (pt) 2002-08-06 2007-07-24 Verdia Inc variantes de ap1 amina oxidase
AU2003258056A1 (en) * 2002-08-07 2004-02-25 Children's Medical Center Corporation Sperm-specific cation channel, catsper-3, and uses therefor
AU2003263981A1 (en) 2002-08-07 2004-02-25 Children's Medical Center Corporation Sperm-specific cation channel, catsper-4, and uses therefor
ES2545736T3 (es) 2002-08-08 2015-09-15 Baylor College Of Medicine Aislamiento e identificación de células T
US20060073475A1 (en) * 2002-08-09 2006-04-06 Nanibhushan Dattagupta Compositions and methods for detecting pathogenic bacteria expressing chaperonin proteins
JP4796299B2 (ja) 2002-08-12 2011-10-19 ジェンネレックス インコーポレイティッド ポックスウイルスおよび癌に関する方法および組成物
WO2004020582A2 (en) * 2002-08-15 2004-03-11 Functional Genetics, Inc. Mammalian genes involved in rapamycin resistance and tumorgenesis: rapr6 genes
AU2003265525A1 (en) * 2002-08-15 2004-03-19 Functional Genetics, Inc. Mammalian genes involved in rapamycin resistance and tumorgenesis: rapr7 genes
WO2004017041A2 (en) 2002-08-15 2004-02-26 Xy, Inc. High resolution flow cytometer
US20050118616A1 (en) * 2002-08-16 2005-06-02 Kawashima Tadashi R. Amplification of target nucleotide sequence without polymerase chain reaction
JP4657919B2 (ja) * 2002-08-19 2011-03-23 プレジデント アンド フェローズ オブ ハーバード カレッジ 進化する新しい分子機能
RS20050834A (en) 2002-08-19 2007-12-31 Abgenix Inc., Antibodies directed to monocyte chemo-attractant protein-1 (mcp-1) and uses thereof
EP2311980A1 (en) 2002-08-20 2011-04-20 Millennium Pharmaceuticals, Inc. Compositions, kits, and methods for identification, assessment, prevention, and therapy of cervical cancer
AU2002950977A0 (en) * 2002-08-22 2002-09-12 Genetype Pty Ltd High resolution analysis of genetic variation within cryptosporidium parvum
US8277753B2 (en) 2002-08-23 2012-10-02 Life Technologies Corporation Microfluidic transfer pin
US7381561B2 (en) * 2002-08-27 2008-06-03 Stemcells California, Inc. Enriched central nervous system stem cell and progenitor cell populations, and methods for identifying, isolating and enriching for such populations
AU2003236461B2 (en) 2002-08-29 2009-05-28 Epigenomics Ag Improved method for bisulfite treatment
EP2143803B1 (en) 2002-09-03 2016-04-13 Quanta Biosciences, Inc. Improved compositions and methods for cDNA synthesis
AU2003270310A1 (en) * 2002-09-05 2004-03-29 Invitrogen Corporation Compositions and methods for synthesizing nucleic acids
US20040109853A1 (en) * 2002-09-09 2004-06-10 Reactive Surfaces, Ltd. Biological active coating components, coatings, and coated surfaces
US7563600B2 (en) 2002-09-12 2009-07-21 Combimatrix Corporation Microarray synthesis and assembly of gene-length polynucleotides
JP4634799B2 (ja) 2002-09-13 2011-02-16 ライフ テクノロジーズ コーポレーション 耐熱性逆転写酵素およびその使用法
US7169548B2 (en) 2002-09-13 2007-01-30 Xy, Inc. Sperm cell processing and preservation systems
AU2002951411A0 (en) * 2002-09-16 2002-09-26 The University Of Sydney Genotype screen
AU2003270824B2 (en) * 2002-09-18 2009-02-19 The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services Recovery of recombinant human parainfluenza virus type 2 (HPIV2) from cDNA and use of recombinant HPIV2 in immunogenic compositions and as vectors to elicit immune responses against PIV and other human pathogens
CA2498764C (en) 2002-09-20 2015-11-10 New England Biolabs, Inc. Helicase dependent amplification of nucleic acids
JP2006500030A (ja) * 2002-09-20 2006-01-05 イェール ユニバーシティ リボスイッチ、その使用方法、ならびにリボスイッチとともに用いるための組成物
US7662594B2 (en) * 2002-09-20 2010-02-16 New England Biolabs, Inc. Helicase-dependent amplification of RNA
US7361821B2 (en) * 2002-09-20 2008-04-22 Intel Corporation Controlled alignment of nanobarcodes encoding specific information for scanning probe microscopy (SPM) reading
WO2004026804A1 (en) * 2002-09-20 2004-04-01 Integrated Dna Technologies, Inc. Anthraquinone quencher dyes, their methods of preparation and use
JP4520857B2 (ja) * 2002-09-20 2010-08-11 インテル・コーポレーション 走査型プローブ顕微鏡検査（ｓｐｍ）読取用の特定の情報をエンコードするナノバーコードの制御された整列
EP2380900A1 (en) 2002-09-23 2011-10-26 E. I. du Pont de Nemours and Company Isolation and use of ryanodine receptors
EP1403379A1 (en) * 2002-09-24 2004-03-31 QIAGEN GmbH Enhanced coamplification of nucleic acids
US7074598B2 (en) * 2002-09-25 2006-07-11 Mayo Foundation For Medical Education And Research Detection of vancomycin-resistant enterococcus spp.
US7365176B2 (en) * 2002-09-26 2008-04-29 Mayo Foundation For Medical Education And Research Detection of Epstein-Barr virus
US7074599B2 (en) * 2002-09-27 2006-07-11 Mayo Foundation For Medical Education And Research Detection of mecA-containing Staphylococcus spp.
US20050009051A1 (en) * 2002-09-27 2005-01-13 Board Of Regents, The University Of Texas Diagnosis of mould infection
US7534872B2 (en) * 2002-09-27 2009-05-19 Syngen, Inc. Compositions and methods for the use of FMOC derivatives in DNA/RNA synthesis
US7094879B2 (en) 2002-10-02 2006-08-22 Abbott Laboratories Genetically engineered P30 antigen, improved antigen cocktail, and uses thereof
CA2499891A1 (en) * 2002-10-03 2004-04-15 Large Scale Biology Corporation Multimeric protein engineering
CA2501238A1 (en) * 2002-10-04 2004-04-22 Regents Of The University Of Minnesota Nucleic acid and polypeptide sequences from lawsonia intracellularis and methods of using
EP1546304B1 (en) * 2002-10-04 2013-05-08 Danisco US Inc. Improved production of bacterial strains
US20050079617A1 (en) 2003-10-03 2005-04-14 Cervin Marguerite A. Glucose transport mutants for production of biomaterial
PL211654B1 (pl) * 2002-10-08 2012-06-29 Rinat Neuroscience Corp Przeciwciało skierowane przeciwko NGF do zastosowania w leczeniu bólu pooperacyjnego, zastosowanie tego przeciwciała do wytwarzania leku do leczenia bólu pooperacyjnego i kompozycja farmaceutyczna zawierająca przeciwciało skierowane przeciwko NGF do zastosowania w leczeniu bólu pooperacyjnego
AU2003304238A1 (en) 2002-10-08 2005-01-13 Rinat Neuroscience Corp. Methods for treating post-surgical pain by administering an anti-nerve growth factor antagonist antibody and compositions containing the same
UA80447C2 (en) * 2002-10-08 2007-09-25 Methods for treating pain by administering nerve growth factor antagonist and opioid analgesic
JP2006519762A (ja) * 2002-10-09 2006-08-31 ライナット ニューロサイエンス コーポレイション アミロイドβペプチド及びその組成物に対する抗体を使用して、アルツハイマー病を治療する方法
US20080293750A1 (en) * 2002-10-17 2008-11-27 Anna Helgadottir Susceptibility Gene for Myocardial Infarction, Stroke, Paod and Methods of Treatment
US7606403B2 (en) * 2002-10-17 2009-10-20 Intel Corporation Model-based fusion of scanning probe microscopic images for detection and identification of molecular structures
US20070059692A1 (en) 2002-10-28 2007-03-15 Xiaolian Gao Array oligomer synthesis and use
PL210988B1 (pl) * 2002-10-29 2012-03-30 Monsanto Canada Inc Sposoby oznaczania u roślin Brassica tolerancji na herbicyd imidazolinonowy uwarunkowanej przez mutację PM1 i PM2 oraz sposób hodowania roślin z rodzaju Brassica z wykorzystaniem znacznika
EP1564301A4 (en) * 2002-10-29 2007-07-11 Riken METHOD FOR AMPLIFYING NUCLEIC ACID
US20050037369A1 (en) * 2002-10-31 2005-02-17 Neote Kuldeep Singh Panels of molecular targets differentially expressed during CD8+ T cell priming, and methods for therapy and diagnosis utilizing the same
US7427469B2 (en) * 2002-11-05 2008-09-23 Institut Pasteur Method of treating cytomegalovirus with DC-SIGN blockers
AU2003301804A1 (en) 2002-11-05 2004-06-07 Institut National De La Sante Et De La Recherche Medicale Dc-sign blockers and their use for preventing or treating viral infections.
US20040086892A1 (en) * 2002-11-06 2004-05-06 Crothers Donald M. Universal tag assay
EP1629090B1 (en) * 2002-11-06 2014-03-05 iBio, Inc. Expression of foreign sequences in plants using trans-activation system
US7807802B2 (en) 2002-11-12 2010-10-05 Abbott Lab Polynucleotides for the amplification and detection of Chlamydia trachomatis and Neisseria gonorrhoeae
US7683238B2 (en) * 2002-11-12 2010-03-23 iBio, Inc. and Fraunhofer USA, Inc. Production of pharmaceutically active proteins in sprouted seedlings
WO2004044247A2 (en) * 2002-11-12 2004-05-27 Genolife One step real-time rt pcr kits for the universal detection of organisms in industrial products
KR100858080B1 (ko) * 2002-11-12 2008-09-10 삼성전자주식회사 전기적 신호를 측정하는 ｐｃｒ 증폭 산물을 검출하는 방법
CA2505839A1 (en) * 2002-11-12 2004-05-27 Wyeth A novel pth responsive gene
US8148608B2 (en) * 2004-02-20 2012-04-03 Fraunhofer Usa, Inc Systems and methods for clonal expression in plants
US7692063B2 (en) * 2002-11-12 2010-04-06 Ibio, Inc. Production of foreign nucleic acids and polypeptides in sprout systems
AU2003288660A1 (en) 2002-11-15 2004-06-15 Chiron Srl Unexpected surface proteins in neisseria meningitidis
US20050054097A1 (en) * 2002-11-17 2005-03-10 Tony Peled EX-VIVO expansion of hematopoietic system cell populations in mononuclear cell cultures
FR2847263B1 (fr) 2002-11-18 2006-01-13 Commissariat Energie Atomique Polynucleotide specifique de la cellule pancreatique beta des ilots de langerhans
AU2003298672A1 (en) * 2002-11-19 2005-01-28 Singulex, Inc. Detection of target molecules through interaction with probes
AU2003293013A1 (en) * 2002-11-21 2004-06-18 University Of Massachusets Diagnosing and treating hematopoietic cancers
EP2112229A3 (en) 2002-11-25 2009-12-02 Sequenom, Inc. Methods for identifying risk of breast cancer and treatments thereof
CN102584951A (zh) * 2002-11-25 2012-07-18 金克克国际有限公司 皮肤或毛发结合肽
NZ540889A (en) * 2002-11-25 2008-09-26 Attenuon Llc Peptides which inhibit angiogenesis, cell migration, cell invasion and cell proliferation, compositions and uses thereof
AU2003293015A1 (en) * 2002-11-26 2004-06-18 University Of Utah Research Foundation Microporous materials, methods, and articles for localizing and quantifying analytes
US7829694B2 (en) * 2002-11-26 2010-11-09 Medtronic, Inc. Treatment of neurodegenerative disease through intracranial delivery of siRNA
US7597936B2 (en) 2002-11-26 2009-10-06 University Of Utah Research Foundation Method of producing a pigmented composite microporous material
US7605249B2 (en) * 2002-11-26 2009-10-20 Medtronic, Inc. Treatment of neurodegenerative disease through intracranial delivery of siRNA
US7618948B2 (en) 2002-11-26 2009-11-17 Medtronic, Inc. Devices, systems and methods for improving and/or cognitive function through brain delivery of siRNA
CN1774511B (zh) * 2002-11-27 2013-08-21 斯昆诺有限公司 用于序列变异检测和发现的基于断裂的方法和系统
US20040259226A1 (en) * 2003-05-30 2004-12-23 Robey W. Wade Monitoring for and detecting microbes used in bioterrorism
US20040101860A1 (en) * 2002-11-27 2004-05-27 Jones Alison M. Predicting animal performance
US7947499B2 (en) * 2002-11-29 2011-05-24 Technion Research & Development Foundation Ltd. Method of dynamically culturing embryonic stem cells
US20040248085A1 (en) * 2002-11-29 2004-12-09 Sang-Wha Lee General primers and process for detecting diverse genotypes of human papillomavirus by PCR
EP1594975A4 (en) 2002-12-04 2006-08-02 Applera Corp MULTIPLEX AMPLIFICATION OF POLYNUCLEOTIDES
US7718361B2 (en) 2002-12-06 2010-05-18 Roche Molecular Systems, Inc. Quantitative test for bacterial pathogens
WO2004052085A1 (en) 2002-12-06 2004-06-24 Del Monte Fresh Produce Company Transgenic pineapple plants with modified carotenoid levels and methods of their production
ATE474933T1 (de) 2002-12-06 2010-08-15 Hoffmann La Roche Verfahren zum nachweis von pathogenen organismen
ES2542328T3 (es) 2002-12-06 2015-08-04 Millennium Pharmaceuticals, Inc. Métodos para la identificación, evaluación y tratamiento de pacientes con terapia de inhibición del proteasoma
JP2006516193A (ja) 2002-12-06 2006-06-29 アイシス・ファーマシューティカルス・インコーポレーテッド ヒトおよび動物における病原体の迅速な同定方法
US7491699B2 (en) 2002-12-09 2009-02-17 Ramot At Tel Aviv University Ltd. Peptide nanostructures and methods of generating and using the same
CN1230531C (zh) 2002-12-09 2005-12-07 清华大学 从样品中分离细胞粒子的方法
CN1223680C (zh) * 2002-12-10 2005-10-19 清华大学 扩增靶细胞或病毒的核酸的方法
JP4185763B2 (ja) * 2002-12-12 2008-11-26 富士フイルム株式会社 ターゲット核酸の定量方法
DE60334846D1 (de) 2002-12-12 2010-12-16 R B T Rakuto Bio Technologies VERWENDUNG von LIGNINPEROXIDASE ZUR HAUT- UND HAARAUFHELLUNG
US20050026168A1 (en) 2002-12-13 2005-02-03 Genesis Group Inc. Method for the detection of risk factors associated with myocardial infarction
EP1579002B1 (en) * 2002-12-13 2014-02-12 Geneohm Sciences Canada, Inc. Methods to verify the efficiency of sample preparation and nucleic acid amplification and/or detection
JP4613069B2 (ja) 2002-12-16 2011-01-12 テクニオン リサーチ アンド ディベロップメント ファウンデーション リミテッド 支持細胞非含有、異種非含有のヒト胚性幹細胞の調製方法およびこれらを使用して調製された幹細胞培養物
US8206904B2 (en) 2002-12-18 2012-06-26 Third Wave Technologies, Inc. Detection of nucleic acids
US7851150B2 (en) 2002-12-18 2010-12-14 Third Wave Technologies, Inc. Detection of small nucleic acids
AU2003299441A1 (en) * 2002-12-19 2004-07-14 Centre National De La Recherche Scientifique - Cnrs Nf-hev compositions and methods of use
EP2500440B1 (en) 2002-12-20 2015-12-16 Celera Corporation Genetic polymorphisms associated with myocardial infarction, methods of detection and uses thereof
EP1608952B1 (en) 2002-12-20 2016-08-10 Life Technologies Corporation Assay apparatus and method using microfluidic arrays
US9487823B2 (en) 2002-12-20 2016-11-08 Qiagen Gmbh Nucleic acid amplification
NZ587852A (en) 2002-12-24 2012-02-24 Rinat Neuroscience Corp Anti-NGF antibodies and methods using same
US9498530B2 (en) 2002-12-24 2016-11-22 Rinat Neuroscience Corp. Methods for treating osteoarthritis pain by administering a nerve growth factor antagonist and compositions containing the same
US7569364B2 (en) 2002-12-24 2009-08-04 Pfizer Inc. Anti-NGF antibodies and methods using same
US20060204495A1 (en) * 2002-12-31 2006-09-14 Zang Jingwu Z Isolation and identification of cross-reactive t cells
JP2006512079A (ja) 2003-01-02 2006-04-13 ラッパポート・ファミリー・インスティチュート・フォー・リサーチ・イン・ザ・メディカル・サイエンシズ 高血糖性患者の心疾患を予防するための抗酸化治療の有効性を予測する方法
US7960522B2 (en) 2003-01-06 2011-06-14 Corixa Corporation Certain aminoalkyl glucosaminide phosphate compounds and their use
CA2512108C (en) 2003-01-06 2013-04-02 Corixa Corporation Certain aminoalkyl glucosaminide phosphate compounds and their use
US7297780B2 (en) 2003-01-06 2007-11-20 Third Wave Technologies, Inc. Reactive functional groups for preparation of modified nucleic acid
EP2058275A1 (en) 2003-01-07 2009-05-13 Ramot at Tel-Aviv University Ltd. Peptide nanostructures encapsulating a foreign material and method of manufacturing same
US20040224330A1 (en) * 2003-01-15 2004-11-11 Liyan He Nucleic acid indexing
US20050196766A1 (en) * 2003-12-24 2005-09-08 Soe Jorn B. Proteins
DE602004030000D1 (de) 2003-01-17 2010-12-23 Danisco Verfahren zur in-situ-herstellung eines emulgators in einem nahrungsmittel
DE602004018270D1 (de) * 2003-01-17 2009-01-22 Eragen Biosciences Inc Nukleinsäureamplifikation mit nichtstandardbasen
ES2375492T3 (es) 2003-01-17 2012-03-01 Danisco A/S Procedimiento para la producción in situ de un emulsionante en un alimento.
US7955814B2 (en) * 2003-01-17 2011-06-07 Danisco A/S Method
US9068234B2 (en) 2003-01-21 2015-06-30 Ptc Therapeutics, Inc. Methods and agents for screening for compounds capable of modulating gene expression
US8426194B2 (en) 2003-01-21 2013-04-23 Ptc Therapeutics, Inc. Methods and agents for screening for compounds capable of modulating VEGF expression
WO2004083806A2 (en) 2003-01-22 2004-09-30 University Of South Florida Autonomous genosensor apparatus and methods for use
EP3351919A1 (en) 2003-01-24 2018-07-25 University of Utah Methods of predicting mortality risk by determining telomere length
US7575865B2 (en) * 2003-01-29 2009-08-18 454 Life Sciences Corporation Methods of amplifying and sequencing nucleic acids
EP2261372B1 (en) * 2003-01-29 2012-08-22 454 Life Sciences Corporation Methods of amplifying and sequencing nucleic acids
DE602004009038T3 (de) * 2003-01-29 2015-06-25 Roche Diagnostics Gmbh Verbessertes Verfahren zur Behandlung durch Bisulfit
US20040265320A1 (en) * 2003-01-29 2004-12-30 Karl Salzwedel Inhibition of HIV-1 replication by disruption of the processing of the viral capsid-spacer peptide 1 protein
US7537765B2 (en) * 2003-01-29 2009-05-26 Panacos Pharmaceuticals, Inc. Inhibition of HIV-1 replication by disruption of the processing of the viral capsid-spacer peptide 1 protein
DE10303974A1 (de) 2003-01-31 2004-08-05 Abbott Gmbh & Co. Kg Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung
MX336070B (es) 2003-01-31 2016-01-07 Monsanto Technology Llc Eventos de alfalfa tolerantes a glifosato y metodos para su deteccion.
WO2004069174A2 (en) * 2003-01-31 2004-08-19 Slil Biomedical Corporation Monitoring and treatment of amyotrophic lateral sclerosis
CA2514841A1 (en) * 2003-02-02 2004-08-19 Palo Alto Institute Of Molecular Medicine Cell-killing molecules and methods of use thereof
EP1594956A4 (en) 2003-02-03 2007-08-01 Fraunhofer Usa Inc SYSTEM FOR EXPRESSION OF GENES IN PLANTS
US7732591B2 (en) * 2003-11-25 2010-06-08 Medtronic, Inc. Compositions, devices and methods for treatment of huntington's disease through intracranial delivery of sirna
US7994149B2 (en) 2003-02-03 2011-08-09 Medtronic, Inc. Method for treatment of Huntington's disease through intracranial delivery of sirna
JP4824540B2 (ja) 2003-02-07 2011-11-30 ダイアノキュアー インク． サンプル中の前立腺癌を検出する方法
US20040157220A1 (en) 2003-02-10 2004-08-12 Purnima Kurnool Methods and apparatus for sample tracking
CA2457607A1 (en) * 2003-02-12 2004-08-12 Agroterra Biotech Inc. Method of mutagenic chain reaction
EP1596828B1 (en) 2003-02-14 2011-12-28 Children's Hospital & Research Center at Oakland Lipophilic drug delivery vehicle and methods of use thereof
US20040170982A1 (en) 2003-02-14 2004-09-02 Morris David W. Novel therapeutic targets in cancer
EP1592708A2 (en) 2003-02-14 2005-11-09 Sagres Discovery, Inc. Therapeutic gpcr targets in cancer
US20070218071A1 (en) * 2003-09-15 2007-09-20 Morris David W Novel therapeutic targets in cancer
EP2241330A1 (en) 2003-02-14 2010-10-20 The Curators Of The University Of Missouri Contraceptive methods and compositions related to proteasomal interference
TW200418829A (en) * 2003-02-14 2004-10-01 Avanir Pharmaceutics Inhibitors of macrophage migration inhibitory factor and methods for identifying the same
US7767387B2 (en) * 2003-06-13 2010-08-03 Sagres Discovery, Inc. Therapeutic targets in cancer
US7312202B2 (en) 2003-02-18 2007-12-25 Board Of Regents, The University Of Texas System Rationally designed and chemically synthesized promoter for genetic vaccine and gene therapy
AU2004213044A1 (en) * 2003-02-19 2004-09-02 Rinat Neuroscience Corp. Methods for treating pain by administering a nerve growth factor antagonist and an NSAID and compositions containing the same
US20070025974A1 (en) * 2003-02-26 2007-02-01 Hardings Fiona A Amylases producing an altered immunogenic response and methods of making and using the same
KR20060002793A (ko) * 2003-03-03 2006-01-09 더 보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템 Ｍｄａ-7을 포함하는 방법 및 조성물
EP2319857A3 (en) 2003-03-04 2012-06-27 Yeda Research And Development Co., Ltd. Pon polypeptides, polynucleotides encoding same and compositions and methods utilizing same
US7250296B2 (en) * 2003-03-05 2007-07-31 University Of Florida Research Foundation, Inc. Nucleotide sequences of 2S albumin gene and its promoter from grape and uses thereof
US20040235019A1 (en) * 2003-03-06 2004-11-25 Agouron Pharmaceuticals, Inc. Diagnostics and therapeutics for the gene expression signature of PPAR-gamma receptor ligand
ES2713024T3 (es) 2003-03-06 2019-05-17 Basf Enzymes Llc Amilasas, ácidos nucleicos que las codifican y métodos para su fabricación y uso
US20040175704A1 (en) 2003-03-06 2004-09-09 Stratagene Compositions and methods for polynucleotide sequence detection
US8298799B2 (en) 2003-03-07 2012-10-30 Dsm Ip Assets B. V. Hydrolases, nucleic acids encoding them and methods for making and using them
US8017113B2 (en) 2003-03-12 2011-09-13 Rappaport Family Institute For Research In The Medical Sciences Compositions and methods for diagnosing and treating an inflammation
WO2004081040A2 (en) 2003-03-12 2004-09-23 Advisys, Inc. Insulin-like growth factor (igf-i) plasmid-mediated supplementation for therapeutic applications
CA2519092C (en) 2003-03-14 2014-08-05 Neose Technologies, Inc. Branched water-soluble polymers and their conjugates
EP1604013A4 (en) * 2003-03-17 2009-02-11 Univ Johns Hopkins METHYL GENES ABERRANTY IN PANCREATIC CANCER
US20040185446A1 (en) * 2003-03-18 2004-09-23 Jones Alison M. Cpn60 targets for quantification of microbial species
JP2007525434A (ja) 2003-03-19 2007-09-06 アブジェニックス インコーポレイテッド Ｔ細胞、免疫グロブリンドメインおよびムチンドメイン１（ｔｉｍ−１）抗原に対する抗体およびその使用。
US20040185454A1 (en) * 2003-03-21 2004-09-23 Jones Alison M. Identification and quantification of microbial species in a sample
US20040185434A1 (en) * 2003-03-21 2004-09-23 Robey W. Wade Detecting microbial contamination in animal by-products
US20060192960A1 (en) * 2003-03-24 2006-08-31 Rencs Erik V Polarization detection
AU2004225520A1 (en) 2003-03-25 2004-10-14 Stratagene DNA polymerase fusions and uses thereof
US8017323B2 (en) * 2003-03-26 2011-09-13 President And Fellows Of Harvard College Free reactant use in nucleic acid-templated synthesis
DK2305172T3 (en) 2003-03-28 2016-08-22 Inguran Llc DEVICE AND PROCEDURES TO PROVIDE SEXUAL ANIMAL SEED
GB0307403D0 (en) 2003-03-31 2003-05-07 Medical Res Council Selection by compartmentalised screening
US7067298B2 (en) * 2003-03-31 2006-06-27 Ambion, Inc. Compositions and methods of using a synthetic Dnase I
US20060078893A1 (en) 2004-10-12 2006-04-13 Medical Research Council Compartmentalised combinatorial chemistry by microfluidic control
US8043834B2 (en) 2003-03-31 2011-10-25 Qiagen Gmbh Universal reagents for rolling circle amplification and methods of use
AU2004227353B2 (en) * 2003-04-01 2010-02-25 Luminex Corporation Polymerase inhibitor and method of using same
US7294701B2 (en) * 2003-04-02 2007-11-13 Technion Research & Development Foundation Ltd. Antibody fragment capable of modulating multidrug resistance and compositions and kits and methods using same
DE10315640A1 (de) 2003-04-04 2004-10-14 Ignatov, Konstantin Verfahren zur kontrollierten Freisetzung von Komponenten in eine Lösung
CA2521402C (en) 2003-04-04 2015-01-13 Diversa Corporation Pectate lyases, nucleic acids encoding them and methods for making and using them
ES2369498T3 (es) 2003-04-04 2011-12-01 Yeda Research And Development Co., Ltd. Anticuerpos para inhibir la actividad de mmp-2 y mmp-9.
ES2559053T3 (es) 2003-04-08 2016-02-10 Yeda Research And Development Co., Ltd. Células madre con aumento de sensibilidad a SDF-1 y procedimientos de generación y utilización de las mismas
WO2004092331A2 (en) * 2003-04-08 2004-10-28 Li-Cor, Inc. Composition and method for nucleic acid sequencing
US20070026485A1 (en) 2003-04-09 2007-02-01 Neose Technologies, Inc. Glycopegylation methods and proteins/peptides produced by the methods
US20050233390A1 (en) * 2003-04-09 2005-10-20 Allen John W Device including a proteinaceous factor, a recombinant proteinaceous factor, and a nucleotide sequence encoding the proteinaceous factor
GB0308198D0 (en) 2003-04-09 2003-05-14 Chiron Srl ADP-ribosylating bacterial toxin
FR2853551B1 (fr) 2003-04-09 2006-08-04 Lab Francais Du Fractionnement Formulation stabilisante pour compositions d'immunoglobulines g sous forme liquide et sous forme lyophilisee
WO2004092214A2 (en) * 2003-04-10 2004-10-28 Aristex Affinity purification system using troponin molecules as affinity ligands
US20050095610A1 (en) * 2003-04-11 2005-05-05 Kuo Sophia S. Method of generating size standard nucleic acids
US20040241732A1 (en) * 2003-04-11 2004-12-02 Chu-An Chang Method of generating long nucleic acid molecules of defined sequence
WO2004092418A2 (en) 2003-04-14 2004-10-28 Nugen Technologies, Inc. Global amplification using a randomly primed composite primer
US8046171B2 (en) 2003-04-18 2011-10-25 Ibis Biosciences, Inc. Methods and apparatus for genetic evaluation
JP5117719B2 (ja) * 2003-04-18 2013-01-16 ベクトン・ディキンソン・アンド・カンパニー 免疫増幅
US20070248978A1 (en) * 2006-04-07 2007-10-25 Expression Diagnostics, Inc. Steroid responsive nucleic acid expression and prediction of disease activity
WO2004096985A2 (en) * 2003-04-24 2004-11-11 Mayo Foundation For Medical Education And Research Methods for assessing biologic diversity
US7892745B2 (en) * 2003-04-24 2011-02-22 Xdx, Inc. Methods and compositions for diagnosing and monitoring transplant rejection
AU2004235331B2 (en) * 2003-04-25 2008-12-18 Sequenom, Inc. Fragmentation-based methods and systems for De Novo sequencing
US8057993B2 (en) 2003-04-26 2011-11-15 Ibis Biosciences, Inc. Methods for identification of coronaviruses
US7897744B2 (en) * 2003-04-28 2011-03-01 The Public Health Agency Of Canada SARS virus nucleotide and amino acid sequences and uses thereof
WO2004098497A2 (en) * 2003-04-28 2004-11-18 Genencor International, Inc. Cd4+ human papillomavirus (hpv) epitopes
US7067123B2 (en) 2003-04-29 2006-06-27 Musculoskeletal Transplant Foundation Glue for cartilage repair
EP2322629A3 (en) 2003-04-29 2011-11-02 Pioneer Hi-Bred International Inc. Novel glyphosate-n-acetyltransferase (GAT) genes
US7413888B2 (en) 2003-05-02 2008-08-19 Novozymes, Inc. Variants of beta-glucosidases
EP2942402A1 (en) 2003-05-02 2015-11-11 Dow AgroSciences LLC Corn event tc1507 and methods for detection thereof
DK2298347T3 (en) 2003-05-06 2016-01-11 Biogen Hemophilia Inc COAGULATION FACTOR CHEMICAL PROTEINS FOR TREATING A HEMOSTATIC DISORDER
TWI353991B (en) 2003-05-06 2011-12-11 Syntonix Pharmaceuticals Inc Immunoglobulin chimeric monomer-dimer hybrids
US20060252120A1 (en) * 2003-05-09 2006-11-09 Kieliszewski Marcia J Synthetic genes for plant gums and other hydroxyproline-rich glycoproteins
AU2003229474A1 (en) * 2003-05-09 2004-11-26 Capital Biochip Company, Ltd. Methods and compositions for detecting sars virus
US8158354B2 (en) 2003-05-13 2012-04-17 Ibis Biosciences, Inc. Methods for rapid purification of nucleic acids for subsequent analysis by mass spectrometry by solution capture
US7964343B2 (en) 2003-05-13 2011-06-21 Ibis Biosciences, Inc. Method for rapid purification of nucleic acids for subsequent analysis by mass spectrometry by solution capture
ES2541121T3 (es) 2003-05-15 2015-07-16 Xy, Llc Clasificación eficiente de células haploides por sistemas de citometría de flujo
US7901457B2 (en) 2003-05-16 2011-03-08 Musculoskeletal Transplant Foundation Cartilage allograft plug
JP2007525188A (ja) 2003-05-16 2007-09-06 インターミューン インコーポレイテッド 合成ケモカイン受容体リガンドおよびその使用方法
US20040235032A1 (en) * 2003-05-19 2004-11-25 Canon Kabushiki Kaisha PCR amplification method, PCR primer set, PCR amplification product, and method for detection of nucleic acid using the amplification method
US7173010B2 (en) * 2003-05-19 2007-02-06 Regents Of The University Of Michigan Orphanin FQ receptor
JP4836795B2 (ja) * 2003-05-19 2011-12-14 ブランデイズ ユニバーシティー 核酸プロセシング方法、キット、及び装置
EP1633893B1 (en) 2003-05-19 2012-01-25 Gen-Probe Incorporated Compositions, methods and kits for determining the presence of trichomonas vaginalis in a test sample
EP1625148B1 (en) 2003-05-21 2012-09-26 Biotech Tools S.A. Peptide complex
US7554007B2 (en) 2003-05-22 2009-06-30 Evogene Ltd. Methods of increasing abiotic stress tolerance and/or biomass in plants
CN100591770C (zh) 2003-05-22 2010-02-24 伊沃基因有限公司 提高植物非生物胁迫耐受性和/或生物量的方法及用该方法所产生的植物
AU2005234725B2 (en) * 2003-05-22 2012-02-23 Evogene Ltd. Methods of Increasing Abiotic Stress Tolerance and/or Biomass in Plants and Plants Generated Thereby
US20050020499A1 (en) * 2003-05-27 2005-01-27 Bar Ilan University Methods of attenuating cocaine seeking behavior employing glial cell-derived neurotrophic factor (GDNF) and pharmaceutical compositions and articles of manufacture suited for use in practice of the method
US7655833B2 (en) 2003-05-29 2010-02-02 Brookhaven Science Associates, Llc ADS genes for reducing saturated fatty acid levels in seed oils
US9708410B2 (en) 2003-05-30 2017-07-18 Janssen Biotech, Inc. Anti-tissue factor antibodies and compositions
WO2004108965A1 (en) * 2003-05-30 2004-12-16 Georgia Tech Research Corporation Methods and reagents for quantitative analysis of dehalococcoides species
US20040241662A1 (en) * 2003-05-30 2004-12-02 Robey W. Wade Detecting microbial contamination in grain and related products
FR2855832B1 (fr) * 2003-06-03 2007-09-14 Biomerieux Sa Procede de diagnostic et/ou de pronostic d'un syndrome septique
WO2005001129A2 (en) * 2003-06-06 2005-01-06 Applera Corporation Mobility cassettes
CN1279056C (zh) * 2003-06-06 2006-10-11 马菁 肿瘤相关抗原sm5－1的特异性抗体及其应用
US20050232926A1 (en) * 2003-06-06 2005-10-20 Oncomax Acquisition Corp. Antibodies specific for cancer associated antigen SM5-1 and uses thereof
BRPI0411247A (pt) 2003-06-09 2006-07-25 Wyeth Corp processo melhorado para a recuperação de vìrus de rna de filamento negativo não segmentado partindo do cdna
EP2316973A1 (en) 2003-06-10 2011-05-04 The Trustees Of Boston University Detection methods for disorders of the lung
PL1654355T3 (pl) 2003-06-13 2010-09-30 Dupont Nutrition Biosci Aps Warianty polipeptydów Pseudomonas o aktywności niemaltogennej egzoamylazy i ich zastosowanie do wytwarzania produktów żywnościowych
US7498428B2 (en) * 2003-06-19 2009-03-03 Evogene Ltd. Nucleotide sequences for regulating gene expression in plant trichomes and constructs and methods utilizing same
US8129514B2 (en) * 2003-06-19 2012-03-06 Evogene Ltd. Nucleotide sequences for regulating gene expression in plant trichomes and constructs and methods utilizing same
EP1663466B1 (en) 2003-06-23 2017-10-11 Pioneer Hi-Bred International Inc. Engineering single-gene-controlled staygreen potential into plants
EP1675941B1 (en) 2003-06-25 2013-05-22 Novozymes A/S Polypeptides having alpha-amylase activity and polynucleotides encoding same
ES2383366T3 (es) 2003-06-25 2012-06-20 Novozymes A/S Enzimas para el tratamiento de almidón
WO2005028615A2 (en) * 2003-06-26 2005-03-31 Invitrogen Corporation Methods and compositions for detecting promoter activity and expressing fusion proteins
US20050158733A1 (en) * 2003-06-30 2005-07-21 Gerber David J. EGR genes as targets for the diagnosis and treatment of schizophrenia
US20070077629A1 (en) * 2003-06-30 2007-04-05 Shigeki Joko Method for modifying nucleotide chain
CN100494399C (zh) * 2003-06-30 2009-06-03 清华大学 一种基于dna芯片的基因分型方法及其应用
CN101415724B (zh) 2003-06-30 2015-12-02 特拉维夫大学未来科技开发有限公司 肽、抗肽抗体以及用它们来诊断和治疗淀粉样蛋白相关疾病的方法
AU2004254640B2 (en) 2003-07-02 2010-08-26 Bp Corporation North America Inc. Glucanases, nucleic acids encoding them and methods for making and using them
TWI372050B (en) 2003-07-03 2012-09-11 Astex Therapeutics Ltd (morpholin-4-ylmethyl-1h-benzimidazol-2-yl)-1h-pyrazoles
DE602004016658D1 (de) * 2003-07-07 2008-10-30 Danisco As Danisco Intellectua Varianten der nicht maltogenen exoamylase aus pseudomonas umfassender lebensmittelzusatz
US8143048B2 (en) * 2003-07-07 2012-03-27 Danisco A/S Exo-specific amylase polypeptides, nucleic acids encoding those polypeptides and uses thereof
US20060057766A1 (en) * 2003-07-08 2006-03-16 Quanxi Jia Method for preparation of semiconductive films
US20070224615A1 (en) * 2003-07-09 2007-09-27 Invitrogen Corporation Methods for assaying protein-protein interactions
FR2857375B1 (fr) * 2003-07-10 2007-11-09 Biomerieux Sa Procede de detection et/ou d'identification de bacteries de genre staphylococcus
AU2004257373B2 (en) 2003-07-16 2011-03-24 Arbutus Biopharma Corporation Lipid encapsulated interfering RNA
PL1651612T3 (pl) 2003-07-22 2012-09-28 Astex Therapeutics Ltd Związki 3,4-pochodne 1h-pirazolu i ich zastosowanie jako kinazy zależne od cyklin (cdk) i modulatory kinazy syntazy glikogenu-3 (gsk-3)
US20050059024A1 (en) 2003-07-25 2005-03-17 Ambion, Inc. Methods and compositions for isolating small RNA molecules
KR101176191B1 (ko) * 2003-07-29 2012-08-22 오츠카 세이야쿠 가부시키가이샤 약제 기인성 과립구 감소증 발증 리스크 판정법
CA2533910A1 (en) * 2003-07-29 2005-02-24 Sigma-Aldrich Co. Methods and compositions for amplification of dna
US7320795B2 (en) * 2003-07-30 2008-01-22 Vaccine Research Institute Of San Diego Rodent hepatitis B virus core proteins as vaccine platforms and methods of use thereof
CA2534060C (en) * 2003-07-30 2012-06-12 Vaccine Research Institute Of San Diego Hepatitis virus core proteins as vaccine platforms and methods of use thereof
US7144712B2 (en) * 2003-07-30 2006-12-05 Vaccine Research Institute Of San Diego Human hepatitis B virus core proteins as vaccine platforms and methods of use thereof
EP2402089A1 (en) 2003-07-31 2012-01-04 Handylab, Inc. Processing particle-containing samples
US20090088982A1 (en) * 2003-07-31 2009-04-02 Fukushima Noelle H Co-detection of single polypeptide and polynucleotide molecules
EP1660632B1 (en) 2003-08-01 2014-02-19 Stratatech Corporation Human skin equivalents expressing exogenous polypeptides
US20050054847A1 (en) * 2003-08-01 2005-03-10 Invitrogen Corporation Compositions and methods for preparing short RNA molecules and other nucleic acids
CA2534382C (en) 2003-08-04 2018-12-11 The Hospital For Sick Children Epm2b gene mutations associated with lafora's disease
NZ545747A (en) 2003-08-06 2010-06-25 Senomyx Inc T1R hetero-oligomeric taste receptors, cell lines that express said receptors, and taste compounds
CA2535029C (en) 2003-08-07 2013-07-16 Healor Ltd. Pharmaceutical compositions and methods for accelerating wound healing
AU2004203649B2 (en) 2003-08-12 2006-01-12 F. Hoffmann-La Roche Ag Thermostable Taq polymerase fragment
CN1839133A (zh) * 2003-08-22 2006-09-27 阿文尼尔药品公司 作为巨噬细胞移动抑制因子的抑制剂的取代的二氮杂萘衍生物及其在治疗人类疾病中的应用
EP1660637A4 (en) 2003-08-25 2009-10-21 Novozymes Inc VARIANTS OF GLYCOSIDE HYDROLASES
EP1670932B1 (en) * 2003-08-27 2011-03-30 Proterec Ltd Libraries of recombinant chimeric proteins
US20100069264A1 (en) * 2003-08-27 2010-03-18 Gil Sharon Libraries of recombinant chimeric proteins
AU2004269395A1 (en) * 2003-08-27 2005-03-10 Stemcells California, Inc. Enriched pancreatic stem cell and progenitor cell populations, and methods for identifying, isolating and enriching for these populations
WO2005074417A2 (en) * 2003-09-03 2005-08-18 Salk Institute For Biological Studies Multiple antigen detection assays and reagents
CA2537796C (en) * 2003-09-03 2013-12-03 Life Patch International, Inc. Personal diagnostic devices and related methods
ES2291917T3 (es) * 2003-09-05 2008-03-01 Cellzome Ag Tratamiento de enfermedades neurodegenerativas.
AU2004271951B2 (en) * 2003-09-05 2008-08-21 Genencor International, Inc. HPV CD8+ T-cell epitopes
US9394565B2 (en) * 2003-09-05 2016-07-19 Agena Bioscience, Inc. Allele-specific sequence variation analysis
JP4824559B2 (ja) 2003-09-09 2011-11-30 ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト 凝固因子ｖｉｉポリペプチド
US7956175B2 (en) 2003-09-11 2011-06-07 Ibis Biosciences, Inc. Compositions for use in identification of bacteria
US8546082B2 (en) 2003-09-11 2013-10-01 Ibis Biosciences, Inc. Methods for identification of sepsis-causing bacteria
US20070243595A1 (en) * 2006-04-14 2007-10-18 Clarkson Kathleen A Modified enzymes, methods to produce modified enzymes and uses thereof
CA2538837C (en) * 2003-09-15 2016-02-09 Genencor International, Inc. Modified xylanases having increased thermostability and alkaline stability
TWI333977B (en) * 2003-09-18 2010-12-01 Symphogen As Method for linking sequences of interest
WO2005027978A2 (en) 2003-09-19 2005-03-31 Novo Nordisk A/S Albumin-binding derivatives of therapeutic peptides
US7570443B2 (en) 2003-09-19 2009-08-04 Applied Biosystems, Llc Optical camera alignment
KR100571817B1 (ko) * 2003-09-19 2006-04-17 삼성전자주식회사 태그 서열에 혼성화하는 검출 프로브를 이용하는 표적핵산의 검출방법
WO2005028629A2 (en) * 2003-09-19 2005-03-31 Applera Corporation Whole genome expression analysis system
US20060024690A1 (en) * 2003-09-19 2006-02-02 Kao H P Normalization of data using controls
US20050064435A1 (en) * 2003-09-24 2005-03-24 Xing Su Programmable molecular barcodes
US7788039B2 (en) * 2003-09-25 2010-08-31 Roche Molecular Systems, Inc. Quantitation of nucleic acids using growth curves
US20070281896A1 (en) * 2003-09-30 2007-12-06 Morris David W Novel compositions and methods in cancer
US7074567B2 (en) * 2003-09-30 2006-07-11 Reliagene Technologies Inc. Assay for human DNA for gender determination
US7432362B2 (en) * 2003-09-30 2008-10-07 Reliagene Technologies Inc. Assay for human DNA for gender determination
US7537889B2 (en) * 2003-09-30 2009-05-26 Life Genetics Lab, Llc. Assay for quantitation of human DNA using Alu elements
CA2540244A1 (en) * 2003-09-30 2005-04-14 Lexicon Genetics Incorporated Methods and compositions for defining gene function
FR2860518B1 (fr) * 2003-10-01 2006-02-17 Biomerieux Sa Procede pour le diagnostic/pronostic du neuroblastome
US7348146B2 (en) * 2003-10-02 2008-03-25 Epoch Biosciences, Inc. Single nucleotide polymorphism analysis of highly polymorphic target sequences
US7625707B2 (en) 2003-10-02 2009-12-01 Ramot At Tel Aviv University Ltd. Antibacterial agents and methods of identifying and utilizing same
US7537890B2 (en) * 2003-10-03 2009-05-26 The Regents Of The University Of Michigan Methods of performing biochemical reactions in a convective flow field
EP1522594A3 (en) * 2003-10-06 2005-06-22 Bayer HealthCare AG Methods and kits for investigating cancer
MXPA06003402A (es) 2003-10-07 2006-06-27 Millennium Pharm Inc Moleculas de acidos nucleicos y proteinas para la identificacion, evaluacion, prevencion y tratamiento de cancer de ovario.
WO2005033145A1 (en) 2003-10-07 2005-04-14 Yeda Research And Development Co. Ltd. Antibodies to nik, their preparation and use
IL158287A0 (en) 2003-10-07 2004-05-12 Yeda Res & Dev Antibodies to nik, their preparation and use
EP1670950A2 (en) * 2003-10-10 2006-06-21 Yissum Research Development Company, of The Hebrew University of Jerusalem Method and kit for assessing anxiety or disposition thereto in a subject
WO2005038039A2 (en) * 2003-10-13 2005-04-28 Genaco Biomedical Products, Inc. Method for multiplex primer based amplification of nucleic acids
US20050186588A1 (en) * 2003-10-16 2005-08-25 Third Wave Technologies, Inc. Direct nucleic acid detection in bodily fluids
DK1677735T3 (da) 2003-10-17 2014-10-27 Joslin Diabetes Center Inc Fremgangsmåder og sammensætninger til modulering af adipocytfunktion
US7910296B2 (en) 2003-10-21 2011-03-22 Orion Genomics Llc Methods for quantitative determination of methylation density in a DNA locus
AU2004283294B2 (en) 2003-10-23 2011-03-17 Kineta Two, Llc Detection of mutations in a gene associated with resistance to viral infection, OAS1
PT1687609E (pt) * 2003-10-28 2015-03-02 Epoch Biosciences Inc Sondas fluorescentes para a detecção de adn por hibridação com uma maior sensibilidade e menor ruído de fundo
EP1692158B1 (en) * 2003-11-06 2011-10-26 Danisco US Inc. Vegf binding and supported peptides for treating skin diseases
JP2007512811A (ja) * 2003-11-10 2007-05-24 インベスチゲン， インコーポレイテッド 検出のための核酸を調製する方法
AU2004290052B2 (en) 2003-11-12 2008-12-04 Corteva Agriscience Llc Delta-15 desaturases suitable for altering levels of polyunsaturated fatty acids in oleaginous plants and yeast
MXPA06005219A (es) 2003-11-12 2007-01-19 Univ Colorado Regents Composiciones y metodos para la regulacion del factor-alfa de necrosis tumoral.
US7169560B2 (en) 2003-11-12 2007-01-30 Helicos Biosciences Corporation Short cycle methods for sequencing polynucleotides
WO2005048938A2 (en) * 2003-11-13 2005-06-02 California Pacific Medical Center Anti-pecam therapy for metastasis suppression
WO2005049849A2 (en) 2003-11-14 2005-06-02 Integrated Dna Technologies, Inc. Fluorescence quenching azo dyes, their methods of preparation and use
JP4675330B2 (ja) 2003-11-14 2011-04-20 デューク ユニバーシティ シャルコー・マリー・ツース病２ａ型の検出方法
JP4581380B2 (ja) * 2003-11-17 2010-11-17 パナソニック株式会社 核酸増幅反応容器およびその製造方法
US20050125914A1 (en) * 2003-11-18 2005-06-16 Gerard Malle Hair shaping composition comprising at least one- non-hydroxide base
US20060094064A1 (en) 2003-11-19 2006-05-04 Sandip Ray Methods and compositions for diagnosis, stratification, and monitoring of alzheimer's disease and other neurological disorders in body fluids
US7985569B2 (en) 2003-11-19 2011-07-26 Danisco Us Inc. Cellulomonas 69B4 serine protease variants
EP1692520A2 (en) * 2003-11-19 2006-08-23 Satoris, Inc. Method for diagnosis, stratification and monitoring of alzheimer's disease
AU2004294547A1 (en) * 2003-11-26 2005-06-16 The Ohio State University Research Foundation Polymorphic CD24 genotypes that are predictive of multiple sclerosis risk and progression
CA2832293C (en) 2003-11-26 2015-08-04 Celera Corporation Single nucleotide polymorphisms associated with cardiovascular disorders and statin response, methods of detection and uses thereof
EP1709198B1 (en) 2003-11-26 2013-08-14 AdvanDx, Inc. Peptide nucleic acid probes for analysis of certain staphylococcus species
US20050244847A1 (en) * 2003-11-26 2005-11-03 Eppendorf Ag Methods and compositions for in vitro amplification of extrachromosomal nucleic acid
EP1697534B1 (en) 2003-12-01 2010-06-02 Life Technologies Corporation Nucleic acid molecules containing recombination sites and methods of using the same
US8034790B2 (en) * 2003-12-01 2011-10-11 Introgen Therapeutics Use of MDA-7 to inhibit pathogenic infectious organisms
JP4435174B2 (ja) 2003-12-02 2010-03-17 エフ．ホフマン−ラ ロシュ アーゲー 重亜硫酸塩処理の改良された方法
EP2664670B1 (en) 2003-12-03 2015-05-06 Danisco US Inc. Perhydrolase
US20060182742A1 (en) * 2004-08-24 2006-08-17 Ishikawa Muriel Y System and method for magnifying a humoral immune response
US20060047436A1 (en) * 2004-08-25 2006-03-02 Ishikawa Muriel Y System and method for magnifying an immune response
US20060116824A1 (en) * 2004-12-01 2006-06-01 Ishikawa Muriel Y System and method for modulating a humoral immune response
US20060047437A1 (en) * 2004-08-25 2006-03-02 Ishikawa Muriel Y System and method for heightening an immune response
US20060122784A1 (en) * 2004-12-03 2006-06-08 Ishikawa Muriel Y System and method for augmenting a humoral immune response
US20060095211A1 (en) * 2003-12-05 2006-05-04 Searete Llc, A Limited Liability Corporation Of The State Of Delaware System and method for modulating a cell mediated immune response
US20060047434A1 (en) * 2004-08-24 2006-03-02 Ishikawa Muriel Y System and method related to improving an immune system
US20060122783A1 (en) * 2004-08-24 2006-06-08 Ishikawa Muriel Y System and method for heightening a humoral immune response
US20060047435A1 (en) * 2004-08-24 2006-03-02 Ishikawa Muriel Y System and method related to augmenting an immune system
EP1699926B1 (en) 2003-12-10 2014-06-18 Monsanto Technology, LLC Stress tolerant plants and methods thereof
AU2004300168A1 (en) * 2003-12-11 2005-06-30 Board Of Regents, The University Of Texas System Method and system for the analysis of saliva using a sensor array
US20050130897A1 (en) * 2003-12-11 2005-06-16 Ma Jian-Xing Compounds useful in inhibiting vascular leakage, inflammation and fibrosis and methods of making and using same
WO2005059100A2 (en) * 2003-12-12 2005-06-30 New York University Methods and compositions relating to cystatin c
US20100221233A1 (en) * 2003-12-15 2010-09-02 University Of South Florida Compositions and methods for enhancing neuroprotection via administration of stem cells and blood brain barrier permeabilizers
US8212113B2 (en) 2003-12-15 2012-07-03 Monsanto Technology Llc Corn plant Mon88017 and compositions and methods for detection thereof
CN1898257B (zh) 2003-12-17 2010-06-23 普雷西斯药品公司 合成编码文库的方法
EP2289567A3 (en) 2003-12-22 2011-06-22 Regentis Biomaterials Ltd. Matrix comprising naturally-occurring crosslinked protein backbone
US7129049B2 (en) 2003-12-22 2006-10-31 Regents Of The University Of Minnesota Method of detecting equine glycogen storage disease IV
CA2551097A1 (en) 2003-12-23 2005-07-14 Rinat Neuroscience Corp. Agonist anti-trkc antibodies and methods using same
US7541185B2 (en) 2003-12-23 2009-06-02 Cythera, Inc. Methods for identifying factors for differentiating definitive endoderm
US7704738B2 (en) * 2003-12-23 2010-04-27 Cythera, Inc. Definitive endoderm
US7625753B2 (en) * 2003-12-23 2009-12-01 Cythera, Inc. Expansion of definitive endoderm cells
US7985585B2 (en) 2004-07-09 2011-07-26 Viacyte, Inc. Preprimitive streak and mesendoderm cells
US20050266554A1 (en) * 2004-04-27 2005-12-01 D Amour Kevin A PDX1 expressing endoderm
US8586357B2 (en) * 2003-12-23 2013-11-19 Viacyte, Inc. Markers of definitive endoderm
US8247576B2 (en) 2003-12-23 2012-08-21 Astex Therapeutics Limited Pyrazole derivatives as protein kinase modulators
US8647873B2 (en) 2004-04-27 2014-02-11 Viacyte, Inc. PDX1 expressing endoderm
US7718408B2 (en) 2003-12-24 2010-05-18 Danisco A/S Method
EP1862554B1 (en) 2003-12-24 2010-03-24 Danisco A/S Enzymatic removal of diglycerides from edible oils
US7906307B2 (en) 2003-12-24 2011-03-15 Danisco A/S Variant lipid acyltransferases and methods of making
GB0716126D0 (en) 2007-08-17 2007-09-26 Danisco Process
WO2008090395A1 (en) * 2007-01-25 2008-07-31 Danisco A/S Production of a lipid acyltransferase from transformed bacillus licheniformis cells
WO2005063977A1 (ja) 2003-12-25 2005-07-14 Riken 核酸の増幅法およびこれを利用した変異核酸の検出法
US20050147979A1 (en) * 2003-12-30 2005-07-07 Intel Corporation Nucleic acid sequencing by Raman monitoring of uptake of nucleotides during molecular replication
US20050147980A1 (en) * 2003-12-30 2005-07-07 Intel Corporation Nucleic acid sequencing by Raman monitoring of uptake of nucleotides during molecular replication
UA86605C2 (ru) 2004-01-12 2009-05-12 Аплайд Молекьюлер Иволюшн, Инк. Антитело, которое содержит вариант исходного человеческого fс-участка
US8007847B2 (en) * 2004-01-13 2011-08-30 Eytan Biderman Feeding formula appliance
EP2133427B1 (en) * 2004-01-14 2013-12-11 Ohio University Methods of producing peptides/proteins in plants and peptides/proteins produced thereby
US20050158710A1 (en) * 2004-01-16 2005-07-21 Shirley Tsang Detection of enterovirus nucleic acid
US7423139B2 (en) * 2004-01-20 2008-09-09 Insight Biopharmaceuticals Ltd. High level expression of recombinant human erythropoietin having a modified 5′-UTR
JP4782700B2 (ja) 2004-01-20 2011-09-28 カロバイオス ファーマシューティカルズ インコーポレイティッド 最低限必須な結合決定基を用いた抗体特異性の移入
CA2553745A1 (en) 2004-01-21 2005-08-04 University Of Utah Research Foundation Mutant sodium channel nav1.7 and methods related thereto
US20060141487A1 (en) * 2004-01-26 2006-06-29 Applera Corporation Methods, compositions, and kits for amplifying and sequencing polynucleotides
AU2005206389A1 (en) * 2004-01-27 2005-08-04 Compugen Ltd. Methods of identifying putative gene products by interspecies sequence comparison and biomolecular sequences uncovered thereby
US8293471B2 (en) * 2004-01-28 2012-10-23 Marshall University Research Corporation Apparatus and method for a continuous rapid thermal cycle system
US20050227563A1 (en) * 2004-01-30 2005-10-13 Bond Eric B Shaped fiber fabrics
US7432057B2 (en) * 2004-01-30 2008-10-07 Michigan State University Genetic test for PSE-susceptible turkeys
US20100216863A1 (en) * 2004-01-30 2010-08-26 Decode Genetics Ehf. Susceptibility Gene for Myocardial Infarction, Stroke, and PAOD; Methods of Treatment
EP1758998B1 (en) 2004-01-30 2010-12-15 Quark Pharmaceuticals, Inc. Oligoribonucleotides and methods of use thereof for treatment of fibrotic conditions and other diseases
DE102004004882A1 (de) * 2004-01-30 2005-08-18 Dade Behring Marburg Gmbh Testsystem und Verfahren zum Nachweis von Analyten
US8158362B2 (en) * 2005-03-30 2012-04-17 Decode Genetics Ehf. Methods of diagnosing susceptibility to myocardial infarction and screening for an LTA4H haplotype
ATE516349T1 (de) 2004-02-04 2011-07-15 Novo Nordisk As Verfahren zur rückfaltung von säuger- glycosyltransferasen
EP1725680B1 (en) * 2004-02-04 2009-12-23 QIAGEN North American Holdings, Inc. Dutp based compositions for reducing primer-aggregate formation during nucleic acid amplification
US20050186606A1 (en) * 2004-02-11 2005-08-25 Schroeder Benjamin G. Methods and compositions for detecting nucleic acids
AU2005211776B2 (en) * 2004-02-11 2012-02-02 Amylin Pharmaceuticals, Llc Pancreatic polypeptide family motifs and polypeptides comprising the same
US7360327B2 (en) * 2004-02-12 2008-04-22 Ralph L. Osgood, Inc. Material moving pusher/bucket
FR2866349B1 (fr) * 2004-02-12 2008-05-16 Biomerieux Sa Procede de diagnostic/pronostic d'une thrombose
EP1564306B1 (en) 2004-02-17 2013-08-07 Affymetrix, Inc. Methods for fragmenting and labeling DNA
WO2005079474A2 (en) 2004-02-17 2005-09-01 The Regents Of The University Of California Detection of nucleic acid sequence differences by comparative genomic hybridization
US7666592B2 (en) 2004-02-18 2010-02-23 Ibis Biosciences, Inc. Methods for concurrent identification and quantification of an unknown bioagent
WO2005080605A2 (en) 2004-02-19 2005-09-01 Helicos Biosciences Corporation Methods and kits for analyzing polynucleotide sequences
EP1716404A4 (en) 2004-02-20 2010-05-05 Univ New York State Res Found METHOD AND DEVICE FOR HANDLING LIQUIDS IN MICROFLUIDIC SYSTEMS
SE0400441D0 (sv) * 2004-02-25 2004-02-25 Active Biotech Ab Novel Benzofurans and Indols
DK1730276T3 (da) * 2004-02-26 2010-09-20 Delta Dansk Elektronik Lys Og Fremgangsmåde, chip, indretning og system til ekstraktion af biologiske materialer
US7932024B2 (en) * 2004-02-26 2011-04-26 Delta, Dansk Elektronik, Lys & Akustik Method, chip, device and system for collection of biological particles
US7892794B2 (en) 2004-02-26 2011-02-22 Delta, Dansk Elektronik, Lys & Akustik Method, chip, device and integrated system for detection biological particles
US8105849B2 (en) 2004-02-27 2012-01-31 Board Of Regents, The University Of Texas System Integration of fluids and reagents into self-contained cartridges containing sensor elements
EP2208797A3 (en) 2004-03-01 2010-11-24 Applied Biosystems, LLC Methods, compositions and kits for use in polynucleotide amplification
US7456149B2 (en) 2004-03-02 2008-11-25 Acceleron Pharma, Inc. ALK7 and myostatin inhibitors and uses thereof
US20070281041A1 (en) * 2004-03-02 2007-12-06 Introgen Therapeutics, Inc. Compositions and Methods Involving MDA-7 for the Treatment of Cancer
US8119336B2 (en) 2004-03-03 2012-02-21 Ibis Biosciences, Inc. Compositions for use in identification of alphaviruses
WO2005087951A2 (en) 2004-03-05 2005-09-22 Gen-Probe Incorporated Reagents, methods and kits for use in deactivating nucleic acids
US8338578B1 (en) 2004-03-05 2012-12-25 Quest Diagnostics Investments Incorporated Cystic fibrosis gene mutations
US20090087854A1 (en) 2007-09-27 2009-04-02 Perlegen Sciences, Inc. Methods for genetic analysis
EP1574583A1 (en) * 2004-03-10 2005-09-14 Roche Diagnostics GmbH Methods for isolation of bacteria from biological samples
US20080025948A1 (en) * 2004-03-10 2008-01-31 Chih-Ping Liu Methods of Treatment Using Interferon-Tau
US20060078942A1 (en) * 2004-03-10 2006-04-13 Pepgen Corporation Method of treatment using interferon-tau
GB0405637D0 (en) 2004-03-12 2004-04-21 Danisco Protein
AU2005222618A1 (en) 2004-03-12 2005-09-29 Biotrove, Inc. Nanoliter array loading
RU2006136267A (ru) * 2004-03-17 2008-04-27 Чирон Корпорейшн (Us) Лечение тяжелой внебольничной пневмонии путем введения ингибитора пути тканевого фактора (tfpi)
US20050208090A1 (en) * 2004-03-18 2005-09-22 Medtronic, Inc. Methods and systems for treatment of neurological diseases of the central nervous system
KR100882249B1 (ko) 2004-03-24 2009-02-06 트리패스 이미징, 인코포레이티드 자궁경부 질환의 검사 방법 및 조성물
FR2868071B1 (fr) * 2004-03-26 2006-06-09 Biomerieux Sa Reactifs de marquage, procedes de synthese de tels reactifs et procedes de detection de molecules biologiques
EP1727911B1 (en) * 2004-03-26 2013-01-23 Sequenom, Inc. Base specific cleavage of methylation-specific amplification products in combination with mass analysis
HUE047016T2 (hu) 2004-03-26 2020-04-28 Dow Agrosciences Llc CRY1F és CRY1AC transzgenikus gyapotvonalak és eseményspecifikus azonosításuk
US20070148749A1 (en) * 2004-03-26 2007-06-28 Shinzo Yasuda Process for producting 1,3-propanediol and or/3-hydroxypropionic acid
EP1730266A2 (en) 2004-03-29 2006-12-13 Monsanto Technology, LLC Sperm suspensions for sorting into x or y chromosome-bearing enriched populations
US20050221339A1 (en) 2004-03-31 2005-10-06 Medical Research Council Harvard University Compartmentalised screening by microfluidic control
FR2868433B1 (fr) 2004-04-06 2008-01-18 Biomerieux Sa Procede pour le pronostic et/ou le diagnostic d'un cancer
US7250298B2 (en) * 2004-04-07 2007-07-31 The University Of Chicago Monomeric red fluorescent proteins
JP5301152B2 (ja) 2004-04-07 2013-09-25 ライナット ニューロサイエンス コーポレイション 神経成長因子アンタゴニストを投与することによって骨癌の疼痛を処置するための方法
EP1735339A2 (en) * 2004-04-09 2006-12-27 Genencor International, Inc. Pcka modifications and enhanced protein expression in bacillus
US7229800B2 (en) * 2004-04-16 2007-06-12 Becton, Dickinson And Company Neisseria gonorrhoeae assay
EP1751177A4 (en) * 2004-04-19 2008-07-16 Univ Ohio NETWORKABLE GLYCOPROTEINS AND METHOD FOR THEIR PRODUCTION
US7595179B2 (en) 2004-04-19 2009-09-29 Applied Biosystems, Llc Recombinant reverse transcriptases
WO2005102309A2 (en) * 2004-04-26 2005-11-03 Ltb4 Sweden Ab In vivo release of endogenous anti-microbial mediators by leukotriene b4 (ltb4) administration
US20080248465A1 (en) * 2004-04-26 2008-10-09 Uab Research Foundation Polymorphisms in the Fcgr2b Promoter and Uses Thereof
US7462451B2 (en) * 2004-04-26 2008-12-09 Third Wave Technologies, Inc. Compositions for modifying nucleic acids
US7919277B2 (en) 2004-04-28 2011-04-05 Danisco A/S Detection and typing of bacterial strains
CA2563433C (en) * 2004-04-30 2010-07-13 Bas Medical, Inc. Methods and compositions for control of fetal growth via modulation of relaxin
ES2407857T5 (es) 2004-04-30 2017-07-31 Dow Agrosciences Llc Nuevo gen de resistencia a los herbicidas
ES2553097T3 (es) 2004-05-03 2015-12-04 Handylab, Inc. Procesamiento de muestras que contienen polinucleótidos
US8852862B2 (en) 2004-05-03 2014-10-07 Handylab, Inc. Method for processing polynucleotide-containing samples
EP1751279A4 (en) * 2004-05-05 2008-03-19 Univ Minnesota NUCLEIC ACIDS AND POLYPEPTIDES INVOLVED IN THE PREPARATION OF CRYPTOPHYCIN
US7939251B2 (en) 2004-05-06 2011-05-10 Roche Molecular Systems, Inc. SENP1 as a marker for cancer
CA2992180C (en) 2004-05-07 2021-02-23 The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. Methods of diagnosing or treating prostate cancer using the erg gene, alone or in combination with other over or under expressed genes in prostate cancer
CA2852855C (en) 2004-05-07 2016-07-05 Celera Corporation Genetic polymorphisms associated with liver fibrosis methods of detection and uses thereof
NZ582558A (en) 2004-05-13 2012-06-29 Anita Goel Nano-PCR: Methods and devices for nucleic acid amplification and detection
WO2005113769A1 (en) * 2004-05-14 2005-12-01 Exact Sciences Corporation Method for stabilizing biological samples for nucleic acid analysis
US20050255485A1 (en) * 2004-05-14 2005-11-17 Livak Kenneth J Detection of gene duplications
GB0410866D0 (en) 2004-05-14 2004-06-16 Chiron Srl Haemophilius influenzae
SI1765085T1 (sl) 2004-05-17 2015-11-30 The General Hospital Corporation Sestavki, ki vsebujejo ženske zarodne matične celice in postopki njihove uporabe
US20060292554A1 (en) * 2004-05-18 2006-12-28 Genentech, Inc. Major coat protein variants for C-terminal and bi-terminal display
JP2007538236A (ja) 2004-05-21 2007-12-27 アトノミックス アクティーゼルスカブ ヒドロゲルを含む表面弾性波センサ
ES2529044T3 (es) 2004-05-21 2015-02-16 Mo Bio Laboratories, Inc. Kits y procedimientos para eliminar contaminantes de ácidos nucleicos en muestras ambientales y biológicas
HUE025727T2 (en) 2004-05-24 2016-04-28 Medimmune Llc Multi-plasmid system for producing influenza virus
CA2567839C (en) 2004-05-24 2011-06-28 Isis Pharmaceuticals, Inc. Mass spectrometry with selective ion filtration by digital thresholding
ATE507305T1 (de) 2004-05-25 2011-05-15 Helicos Biosciences Corp Verfahren zur nukleinsäureimmobilisierung
US7476734B2 (en) 2005-12-06 2009-01-13 Helicos Biosciences Corporation Nucleotide analogs
US20050266411A1 (en) 2004-05-25 2005-12-01 Hofstadler Steven A Methods for rapid forensic analysis of mitochondrial DNA
US7575864B2 (en) * 2004-05-27 2009-08-18 E.I. Du Pont De Nemours And Company Method for the direct detection of diagnostic RNA
EP1758981A4 (en) * 2004-05-28 2013-01-16 Wafergen Inc APPARATUS AND METHODS FOR PERFORMING MULTIPLEX ANALYZES
US7575863B2 (en) 2004-05-28 2009-08-18 Applied Biosystems, Llc Methods, compositions, and kits comprising linker probes for quantifying polynucleotides
CA2572450A1 (en) 2004-05-28 2005-12-15 Ambion, Inc. Methods and compositions involving microrna
CN101133157A (zh) 2004-06-03 2008-02-27 阿什洛米克斯控股有限公司 诊断应激的药物和方法
US7858763B2 (en) * 2004-06-04 2010-12-28 Council Of Scientific And Industrial Research Transforming growth factor beta 1 (TGFβ1) haplotypes and prediction of susceptibility for immunological disorders
PT1766023E (pt) * 2004-06-04 2010-12-09 Fluxome Sciences As Células metabolicamente manipuladas para a produção de ácidos gordos poliinsaturados
CN101793826B (zh) 2004-06-07 2016-04-13 先锋生物科技股份有限公司 用于微流体器件的光学透镜系统和方法
US7604947B2 (en) 2004-06-09 2009-10-20 Cornell Research Foundation, Inc. Detection and modulation of cancer stem cells
WO2005121168A2 (en) * 2004-06-10 2005-12-22 Enkam Pharmaceuticals A/S Heparin binding peptide
ES2665463T3 (es) 2004-06-14 2018-04-25 Evogene Ltd. Polinucleótidos y polipéptidos implicados en el desarrollo de fibra vegetal y métodos de uso de los mismos
AU2005264938B2 (en) 2004-06-16 2011-11-24 Verenium Corporation Compositions and methods for enzymatic decolorization of chlorophyll
US20080311627A1 (en) * 2004-06-17 2008-12-18 Epigenomics Ag Compositions and Methods for Preventing Carry-Over Contamination in Nucleic Acid Amplification Reactions
US20060008844A1 (en) 2004-06-17 2006-01-12 Avidia Research Institute c-Met kinase binding proteins
EP1609871A1 (en) * 2004-06-21 2005-12-28 Biolytix AG Methods and kits for the detection, identification and quantification of bacteria and yeast in food and beverages
CA2571243A1 (en) 2004-06-21 2006-01-05 The Board Of Trustees Of The Leland Stanford Junior University Genes and pathways differentially expressed in bipolar disorder and/or major depressive disorder
JP2008503590A (ja) * 2004-06-21 2008-02-07 メドトロニック・インコーポレーテッド 組成物を細胞にデリバリーするための医学用システム及び方法
US7776530B2 (en) * 2004-06-29 2010-08-17 Wallac Oy Integrated nucleic acid analysis
US20060003337A1 (en) * 2004-06-30 2006-01-05 John Brandis Detection of small RNAS
US7217523B2 (en) * 2004-07-02 2007-05-15 Regents Of The University Of Minnesota Nucleoside phosphoramidates and nucleoside phosphoramidases
US7566532B1 (en) 2004-07-02 2009-07-28 Quest Diagnostics Investments Incorporated Methods for detecting retroviruses
WO2006014292A2 (en) * 2004-07-02 2006-02-09 Dattwyler Raymond J Oral vaccine for borrelia
BRPI0512776A (pt) 2004-07-05 2008-04-08 Novozymes As variante de uma alfa-amilase tipo termamil originária, construto de dna, vetor de expressão recombinante, célula, composição, aditivo de detergente, composição detergente, composição de lavagem de roupa manual ou automática, uso de uma variante de alfa-amilase ou composição, e, método de produzir uma variante
US8680062B2 (en) 2004-07-06 2014-03-25 Deliversir Ltd. System for delivering therapeutic agents into living cells and cells nuclei
EP1767655A4 (en) 2004-07-13 2007-08-01 Takeda Pharmaceutical METHOD FOR CONTROLLING CELL FUCTIONS
AU2005262317B2 (en) 2004-07-13 2009-07-16 Gen-Probe Incorporated Compositions and methods for detection of hepatitis A virus nucleic acid
US7811753B2 (en) 2004-07-14 2010-10-12 Ibis Biosciences, Inc. Methods for repairing degraded DNA
EP2275522A3 (en) * 2004-07-16 2011-09-21 Danisco A/S Enzymatic oil-degumming method
CN101437834B (zh) 2004-07-19 2012-06-06 贝勒医学院 细胞因子信号转导调节剂的调节和用于免疫治疗的应用
US20060024677A1 (en) 2004-07-20 2006-02-02 Morris David W Novel therapeutic targets in cancer
GB2416352B (en) * 2004-07-21 2009-01-28 Bioline Ltd A method for performing the hot start of enzymatic reactions
WO2006007664A1 (en) * 2004-07-22 2006-01-26 Genomics Research Partners Pty Ltd Agents and methods for diagnosing osteoarthritis
CA2574499C (en) 2004-07-22 2016-11-29 Monsanto Technology Llc Process for enriching a population of sperm cells
WO2006022628A1 (en) * 2004-07-22 2006-03-02 Sequenom, Inc. Methods for identifying risk of type ii diabetes and treatments thereof
EP1771466B1 (en) * 2004-07-23 2010-05-26 GE Healthcare UK Limited Cell cycle phase markers
FR2873388B1 (fr) * 2004-07-23 2012-04-06 Biomerieux Sa Procede de marquage et de purification d'acides nucleiques d'interet presents dans un echantillon biologique a traiter dans un unique recipient reactionnel
WO2006025995A2 (en) * 2004-07-27 2006-03-09 The Regents Of The University Of California Compositions and methods using md-2 mutants and chimeric proteins
EP1789437A4 (en) * 2004-07-30 2008-11-05 Sinai School Medicine INHIBITORS OF NPC1L1 AND NPC1L1 AND METHODS OF USE THEREOF
US7943294B2 (en) 2004-07-30 2011-05-17 Hologic, Inc. Methods for detecting oncofetal fibronectin
EA016357B1 (ru) 2004-07-30 2012-04-30 Ринат Ньюросайенс Корп. Антитела, направленные против бета-амилоидного пептида, и способы их применения
US20060024204A1 (en) * 2004-08-02 2006-02-02 Oldenburg Kevin R Well plate sealing apparatus and method
WO2006013926A1 (ja) 2004-08-05 2006-02-09 Universal Bio Research Co., Ltd. 反応容器、反応容器液導入装置、液導入反応測定装置、および液導入装置
EP1623996A1 (en) * 2004-08-06 2006-02-08 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Improved method of selecting a desired protein from a library
JP2008513356A (ja) * 2004-08-09 2008-05-01 アリオス バイオファーマ インク． 合成高度糖鎖付加プロテアーゼ耐性ポリペプチド変異体、それを使用する経口製剤および方法
US7597884B2 (en) 2004-08-09 2009-10-06 Alios Biopharma, Inc. Hyperglycosylated polypeptide variants and methods of use
US20060073168A1 (en) * 2004-08-11 2006-04-06 Stephens David S Neisseria meningitidis serogroup a capsular polysaccharide acetyltransferase, methods and compositions
US7732479B2 (en) 2004-08-19 2010-06-08 Tel Aviv University Future Technology Development L.P. Compositions for treating amyloid associated diseases
US7585626B1 (en) 2004-08-19 2009-09-08 Quest Diagnostics Investments Incorporated Methods for nucleic acid amplification
US20060047439A1 (en) * 2004-08-24 2006-03-02 Searete Llc, A Limited Liability Corporation Of The State Of Delaware System and method for improving a humoral immune response
US20070265788A1 (en) * 2004-08-24 2007-11-15 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Computational methods and systems for augmenting cell-mediated immune response
US20070265818A1 (en) * 2004-08-24 2007-11-15 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Computational methods and systems for heightening cell-mediated immune response
WO2006135400A2 (en) 2004-08-24 2006-12-21 Isis Pharmaceuticals, Inc. Methods for rapid identification of recombinant organisms
US20070265817A1 (en) * 2004-08-24 2007-11-15 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Computational systems and methods relating to fortifying an immune system
US20070207492A1 (en) * 2004-08-24 2007-09-06 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Computational methods and systems to adjust a humoral immune response
US20070265787A1 (en) * 2004-08-24 2007-11-15 Searete Llc,A Limited Liability Corporation Of The State Of Delaware Computational methods and systems for magnifying cell-mediated immune response
US20070288173A1 (en) * 2004-08-24 2007-12-13 Searete Llc, A Limited Liability Corporation Of The State Of Delware Computational methods and systems to reinforce a humoral immune response
US20070198196A1 (en) * 2004-08-24 2007-08-23 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Computational systems and methods relating to ameliorating an immune system
JP4861324B2 (ja) 2004-08-27 2012-01-25 ジェン−プロウブ インコーポレイテッド 単一プライマー核酸増幅法
US20070087376A1 (en) * 2004-08-30 2007-04-19 Potashkin Judith A Splice variants of pre-mRNA transcripts as biomarkers in idiopathic neurodegenerative diseases
US20060057624A1 (en) * 2004-08-30 2006-03-16 Potashkin Judith A Alternatively spliced pre-mRNA transcripts in neurodegenerative disease
JP4440857B2 (ja) 2004-09-01 2010-03-24 三星電子株式会社 リアルタイム核酸増幅データから初期核酸濃度を定量化する方法
KR100738073B1 (ko) 2004-09-01 2007-07-12 삼성전자주식회사 실시간 핵산 증폭 데이터로부터 초기 핵산 농도를정량화하는 방법
US7456270B2 (en) * 2004-09-01 2008-11-25 Abbott Laboratories Δ6-desaturase genes and uses thereof
EP1632578A1 (en) * 2004-09-03 2006-03-08 Roche Diagnostics GmbH DNA decontamination method
US7645575B2 (en) * 2004-09-08 2010-01-12 Xdx, Inc. Genes useful for diagnosing and monitoring inflammation related disorders
US20060057627A1 (en) * 2004-09-08 2006-03-16 Board Of Regents, The University Of Texas System Selection scheme for enzymatic function
AU2005284980A1 (en) * 2004-09-10 2006-03-23 Sequenom, Inc. Methods for long-range sequence analysis of nucleic acids
WO2006031870A2 (en) 2004-09-14 2006-03-23 Argos Therapeutics, Inc. Strain independent amplification of pathogens and vaccines thereto
ES2345993T3 (es) 2004-09-14 2010-10-07 The Regents Of The University Of Colorado, A Body Corporate Metodo para el tratamiento con bucindolol basado en direccionamiento genetico.
EP2412829A1 (en) 2004-09-14 2012-02-01 John Wayne Cancer Institute Detection of cancer cells in body fluids
US20060063187A1 (en) * 2004-09-15 2006-03-23 Hotamisligil Gokhan S Modulation of XBP-1 activity for treatment of metabolic disorders
FI20041204A0 (fi) 2004-09-16 2004-09-16 Riikka Lund Menetelmät immuunivälitteisiin sairauksiin liittyvien uusien kohdegeenien hyödyntämiseksi
EP1799812A4 (en) 2004-09-16 2009-09-09 Gamida Cell Ltd EX VIVO CULTIVATION METHODS OF STEM CELLS AND PRECURSOR BY CO-CULTURE WITH MESENCHYMAL CELLS
US20060073506A1 (en) 2004-09-17 2006-04-06 Affymetrix, Inc. Methods for identifying biological samples
WO2006034009A2 (en) * 2004-09-20 2006-03-30 Sigma-Aldrich Co. Purification of biomolecules from contaminating intact nucleic acids
US7987056B2 (en) 2004-09-20 2011-07-26 The Regents Of The University Of Colorado, A Body Corporate Mixed-library parallel gene mapping quantitative micro-array technique for genome-wide identification of trait conferring genes
EP2186908A1 (en) * 2004-09-21 2010-05-19 Applied Biosystems, LLC Two-color real-time/end-point quantitation of microRNAs (miRNAs)
AU2005288522B2 (en) 2004-09-28 2012-06-28 Quark Pharmaceuticals, Inc. Oligoribonucleotides and methods of use thereof for treatment of alopecia, acute renal failure and other diseases
NZ554787A (en) 2004-09-29 2009-05-31 Collplant Ltd Collagen producing plants and methods of generating and using same
FR2876116B1 (fr) * 2004-10-01 2007-04-06 Biomerieux Sa Methode pour generer des transcrits
GB0422052D0 (en) 2004-10-04 2004-11-03 Dansico As Enzymes
US20060073489A1 (en) 2004-10-05 2006-04-06 Gangqiang Li Nanopore separation devices and methods of using same
JPWO2006038643A1 (ja) 2004-10-06 2008-08-07 ユニバーサル・バイオ・リサーチ株式会社 反応容器、および反応制御装置
US7968287B2 (en) 2004-10-08 2011-06-28 Medical Research Council Harvard University In vitro evolution in microfluidic systems
US7837740B2 (en) * 2007-01-24 2010-11-23 Musculoskeletal Transplant Foundation Two piece cancellous construct for cartilage repair
EP1809374A4 (en) * 2004-10-12 2008-09-10 Closed Loop Therapies Ltd IMPLANTABLE METHODS AND DEVICES FOR TREATING SUPRAVENTRICULAR ARRHYTHMIAS
US20060078894A1 (en) * 2004-10-12 2006-04-13 Winkler Matthew M Methods and compositions for analyzing nucleic acids
GB0423139D0 (en) * 2004-10-18 2004-11-17 Danisco Enzymes
JP5165376B2 (ja) * 2004-10-18 2013-03-21 ブランデイズ ユニバーシティー Ｐｃｒ増幅での再現性の改善およびミスプライミングの低減のための試薬および方法
US7445896B2 (en) * 2004-10-18 2008-11-04 University Of Washington Methods and compositions for detecting VKORC1 single nucleotide polymorphisms
RU2460804C2 (ru) * 2004-10-18 2012-09-10 Брандейс Юнивесити Способ гомогенной детекции по меньшей мере одного продукта одноцепочечной амплификации
US20060188937A1 (en) * 2004-10-19 2006-08-24 Board Of Regents, The University Of Texas System G-protein estrogen membrane receptor
AU2005333603A1 (en) 2004-10-21 2007-01-04 Wyeth Immunogenic compositions of Staphylococcus epidermidis polypeptide antigens
MY179032A (en) 2004-10-25 2020-10-26 Cancer Research Tech Ltd Ortho-condensed pyridine and pyrimidine derivatives (e.g.purines) as protein kinase inhibitors
UY29177A1 (es) 2004-10-25 2006-05-31 Astex Therapeutics Ltd Derivados sustituidos de purina, purinona y deazapurina, composiciones que los contienen métodos para su preparación y sus usos
AU2005299590B2 (en) 2004-10-27 2010-09-16 Cepheid Closed-system multi-stage nucleic acid amplification reactions
JP2008520191A (ja) 2004-10-27 2008-06-19 バンダービルト・ユニバーシティ 感染に関与する哺乳動物遺伝子
US7682782B2 (en) 2004-10-29 2010-03-23 Affymetrix, Inc. System, method, and product for multiple wavelength detection using single source excitation
CA2524964A1 (en) 2004-10-29 2006-04-29 Affymetrix, Inc. Automated method of manufacturing polymer arrays
EP1814583A2 (en) 2004-11-01 2007-08-08 Novartis Vaccines and Diagnostics, Inc. Combination approaches for generating immune responses
WO2006050499A2 (en) * 2004-11-03 2006-05-11 Third Wave Technologies, Inc. Single step detection assay
CN101137758B (zh) 2004-11-03 2012-10-10 意力速分子诊断股份有限公司 均相分析物检测
GB0424940D0 (en) 2004-11-11 2004-12-15 Danisco Transcription factors
DK2302055T3 (da) 2004-11-12 2014-10-13 Asuragen Inc Fremgangsmåder og sammensætninger involverende miRNA og miRNA-inhibitormolekyler
US7051536B1 (en) * 2004-11-12 2006-05-30 Bio-Rad Laboratories, Inc. Thermal cycler with protection from atmospheric moisture
US20060105348A1 (en) * 2004-11-15 2006-05-18 Lee Jun E Compositions and methods for the detection and discrimination of nucleic acids
US20060275792A1 (en) * 2004-11-15 2006-12-07 Lee Jun E Enhancement of nucleic acid amplification using double-stranded DNA binding proteins
EP1666150B1 (en) 2004-11-20 2015-01-07 Roche Diagnostics GmbH Nucleic acid preparation
WO2006058202A2 (en) * 2004-11-24 2006-06-01 The Regents Of The University Of Colorado Mer diagnostic and therapeutic agents
GB0426146D0 (en) 2004-11-29 2004-12-29 Bioxell Spa Therapeutic peptides and method
GB2420560A (en) 2004-11-30 2006-05-31 Bioline Ltd A method for increasing the specificity of enzymatic DNA synthesis
US7842794B2 (en) 2004-12-17 2010-11-30 Roche Molecular Systems, Inc. Reagents and methods for detecting Neisseria gonorrhoeae
JP4534138B2 (ja) * 2004-12-21 2010-09-01 アイシン精機株式会社 核酸増幅反応における高度好熱菌由来タンパク質の活性化方法およびその利用
CA2592104C (en) 2004-12-22 2016-05-10 Novozymes A/S Enzymes for starch processing
GB0428082D0 (en) 2004-12-22 2005-01-26 Welcome Trust The Ltd Therapeutic compounds
DK1926753T3 (da) 2004-12-22 2011-03-14 Novozymes As Hybridenzymer, der består af en endoamylase som første aminosyresekvens og et kulhydratbindingsmodul som anden aminosyresekvens
US20060142228A1 (en) * 2004-12-23 2006-06-29 Ambion, Inc. Methods and compositions concerning siRNA's as mediators of RNA interference
CA2591221A1 (en) * 2004-12-23 2006-07-06 Genencor International, Inc. Neutral cellulase catalytic core and method of producing same
DE602005020691D1 (de) 2004-12-23 2010-05-27 Ge Healthcare Bio Sciences Rna-amplifikation auf ligationsbasis
CA2491067A1 (en) 2004-12-24 2006-06-24 Stichting Katholieke Universiteit Mrna rations in urinary sediments and/or urine as a prognostic marker for prostate cancer
US7736818B2 (en) 2004-12-27 2010-06-15 Inphase Technologies, Inc. Holographic recording medium and method of making it
US7220549B2 (en) 2004-12-30 2007-05-22 Helicos Biosciences Corporation Stabilizing a nucleic acid for nucleic acid sequencing
MX2007008008A (es) 2004-12-30 2007-11-12 Astex Therapeutics Ltd Compuestos de pirazol que modulan la actividad de las cinasas cdk, gsk y aurora.
US20060228726A1 (en) * 2005-01-06 2006-10-12 Martin Patrick K Polypeptides having nucleic acid binding activity and compositions and methods for nucleic acid amplification
ES2589582T3 (es) * 2005-01-07 2016-11-15 Monsanto Invest B.V. Virus de plantas denominado virus del torrado del tomate
CA2593282C (en) 2005-01-10 2016-03-15 Novozymes A/S Production of fatty acid alkyl esters by use of two lipolytic enzymes
US8375327B2 (en) 2005-01-16 2013-02-12 Zlango Ltd. Iconic communication
JP2008529325A (ja) * 2005-01-16 2008-07-31 ズランゴー リミテッド 通信ネットワークシステムおよびそれを使用するための方法
EP1851332A4 (en) * 2005-01-21 2010-05-26 Gene Express Inc METHOD AND COMPOSITIONS FOR THE EVALUATION OF NUCLEIC ACIDS
BRPI0606480A (pt) 2005-01-21 2008-03-11 Astex Therapeutics Ltd compostos farmacêuticos
AU2006332045A1 (en) 2005-01-27 2007-08-16 The Regents Of The University Of California Therapeutic monoclonal antibodies that neutralize botulinum neurotoxins
US9505846B2 (en) 2005-01-28 2016-11-29 Life Technologies Corporation Multi-component inhibitors of nucleic acid polymerases
US7482120B2 (en) 2005-01-28 2009-01-27 Helicos Biosciences Corporation Methods and compositions for improving fidelity in a nucleic acid synthesis reaction
FR2881437B1 (fr) 2005-01-31 2010-11-19 Biomerieux Sa Procede pour le diagnostic/pronostic d'un syndrome septique
ES2562406T3 (es) 2005-01-31 2016-03-04 Realbio Technologies Ltd. Dispositivo capilar de flujo lateral de reacción multietapa
EP2272983A1 (en) 2005-02-01 2011-01-12 AB Advanced Genetic Analysis Corporation Reagents, methods and libraries for bead-based sequencing
EP2241637A1 (en) 2005-02-01 2010-10-20 AB Advanced Genetic Analysis Corporation Nucleic acid sequencing by performing successive cycles of duplex extension
EP1846446B1 (en) 2005-02-02 2013-06-26 Novo Nordisk A/S Insulin derivatives
ES2490243T3 (es) 2005-02-02 2014-09-03 Novo Nordisk A/S Derivados de insulina
US7524631B2 (en) 2005-02-02 2009-04-28 Patterson Bruce K HPV E6, E7 mRNA assay and methods of use thereof
US7790363B2 (en) 2005-02-07 2010-09-07 Abbott Laboratories Inc. Diagnostic test for vitamin B12
KR101379364B1 (ko) * 2005-02-08 2014-03-31 보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템 암 치료를 위한 ｍｄａ-7을 포함하는 조성물
CA2597065C (en) 2005-02-08 2014-10-14 Research Development Foundation Compositions and methods related to soluble g-protein coupled receptors (sgpcrs)
US7393665B2 (en) 2005-02-10 2008-07-01 Population Genetics Technologies Ltd Methods and compositions for tagging and identifying polynucleotides
US20090068650A1 (en) * 2005-02-11 2009-03-12 Southern Illinois University Metabolic Primers for the Detection of (Per) Chlorate-Reducing Bacteria and Methods of Use Thereof
CA2597673C (en) 2005-02-11 2014-07-08 Harold Varmus Methods and compositions for detecting a drug resistant egfr mutant
WO2006091517A2 (en) 2005-02-18 2006-08-31 Novartis Vaccines And Diagnostics Inc. Immunogens from uropathogenic escherichia coli
US20060205081A1 (en) * 2005-02-18 2006-09-14 Linhong Li Use of methyltransferase inhibitors to enhance transgene expression
EP1856298B1 (en) 2005-02-18 2017-09-27 Monogram BioSciences, Inc. Methods and compositions for determining anti-hiv drug susceptibility and replication capacity of hiv
PL2351772T3 (pl) 2005-02-18 2017-01-31 Glaxosmithkline Biologicals Sa Białka i kwasy nukleinowe z bakterii Escherichia coli związanej z zapaleniem opon mózgowo-rdzeniowych/posocznicą
US8178291B2 (en) 2005-02-18 2012-05-15 Monogram Biosciences, Inc. Methods and compositions for determining hypersusceptibility of HIV-1 to non-nucleoside reverse transcriptase inhibitors
GB0503546D0 (en) * 2005-02-21 2005-03-30 Hellenic Pasteur Inst Antibody
US8216801B2 (en) 2005-02-25 2012-07-10 The State Of Israel, Ministry Of Agriculture & Rural Development, Agricultural Research Organization, (A.R.O.), The Volcani Center Methods for treating inflammatory disorders
KR100746372B1 (ko) * 2005-02-28 2007-08-03 바이오퀘스트(주) 핵산 분자가 포함되는 직접 효소 반응 방법
US8182992B2 (en) * 2005-03-03 2012-05-22 Ibis Biosciences, Inc. Compositions for use in identification of adventitious viruses
US8084207B2 (en) 2005-03-03 2011-12-27 Ibis Bioscience, Inc. Compositions for use in identification of papillomavirus
PT1856257E (pt) 2005-03-05 2012-01-02 Seegene Inc Processos utilizando um oligonucleótido de especificidade dual e oligonucleótido de especificidade dual utilizado
WO2006095941A1 (en) 2005-03-05 2006-09-14 Seegene, Inc. Processes using dual specificity oligonucleotide and dual specificity oligonucleotide
CA2614769A1 (en) 2005-03-10 2006-09-21 Verenium Corporation Lyase enzymes, nucleic acids encoding them and methods for making and using them
US8008066B2 (en) 2005-03-10 2011-08-30 Gen-Probe Incorporated System for performing multi-formatted assays
WO2006099365A2 (en) 2005-03-11 2006-09-21 Applera Corporation Genetic polymorphisms associated with coronary heart disease, methods of detection and uses thereof
EP1861506B1 (en) 2005-03-15 2015-04-15 BP Corporation North America Inc. Cellulases, nucleic acids encoding them and methods for making and using them
US20070026423A1 (en) * 2005-03-16 2007-02-01 Thomas Koehler Method and test kit for the detection of target nucleic acids
WO2006101913A2 (en) * 2005-03-18 2006-09-28 Eragen Biosciences, Inc. Methods for detecting multiple species and subspecies of neiserria
WO2007059082A1 (en) 2005-11-10 2007-05-24 Curagen Corporation Method of treating ovarian and renal cancer using antibodies against t cell immunoglobulin domain and mucin domain 1 (tim-1) antigen
EA201201550A1 (ru) 2005-03-21 2013-08-30 Вайробей, Инк. Производные альфа-кетоамидов в качестве ингибиторов цистеинпротеаз
EP3354265A1 (en) 2005-03-22 2018-08-01 President and Fellows of Harvard College Treatment of solid tumors
WO2006102497A2 (en) * 2005-03-22 2006-09-28 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for diagnosis, monitoring and development of therapeutics for treatment of atherosclerotic disease
EA015584B1 (ru) 2005-03-23 2011-10-31 Генмаб А/С Антитело к cd38 человека и его применение
US20060229314A1 (en) * 2005-03-24 2006-10-12 Jagadish Sircar Thienopyridinone derivatives as macrophage migration inhibitory factor inhibitors
WO2006104677A2 (en) 2005-03-24 2006-10-05 Millennium Pharmaceuticals, Inc. Antibodies that bind ov064 and methods of use therefor
DK1866339T3 (da) 2005-03-25 2013-09-02 Gitr Inc GTR-bindende molekyler og anvendelser heraf
US20060257902A1 (en) * 2005-03-25 2006-11-16 Ambion, Inc. Methods and compositions for depleting abundant RNA transcripts
US7964557B2 (en) * 2005-03-28 2011-06-21 University Of Louisville Research Foundation, Inc. Inhibition of wet type age related macular degeneration (AMD) by adiponectin or acrp 30
US8715988B2 (en) 2005-03-28 2014-05-06 California Institute Of Technology Alkane oxidation by modified hydroxylases
EP1863519B1 (en) 2005-03-31 2013-09-25 The General Hospital Corporation Modulating hgf/hgfr activity for treating lymphodema
EP1863908B1 (de) 2005-04-01 2010-11-17 Qiagen GmbH Reverse transkription und amplifikation von rna bei simultaner degradierung von dna
US20060223071A1 (en) * 2005-04-01 2006-10-05 Wisniewski Michele E Methods, compositions, and kits for detecting nucleic acids in a single vessel
US20060275798A1 (en) * 2005-04-04 2006-12-07 Steichen John C Detection of organisms using a media sachet and primer directed nucleic acid amplification
US20060246493A1 (en) 2005-04-04 2006-11-02 Caliper Life Sciences, Inc. Method and apparatus for use in temperature controlled processing of microfluidic samples
EP2083088A3 (en) 2005-04-07 2009-10-14 Novartis Vaccines and Diagnostics, Inc. Cancer-related genes
EP2062591A1 (en) 2005-04-07 2009-05-27 Novartis Vaccines and Diagnostics, Inc. CACNA1E in cancer diagnosis detection and treatment
US20070154992A1 (en) 2005-04-08 2007-07-05 Neose Technologies, Inc. Compositions and methods for the preparation of protease resistant human growth hormone glycosylation mutants
ES2374419T3 (es) 2005-04-11 2012-02-16 National Research Council Of Canada Identificación de una beta-1,3-n-acetilgalactosaminiltranferasa (cgte) de campylobacter jejuni lio87.
EP1877576B1 (en) 2005-04-12 2013-01-23 454 Life Sciences Corporation Methods for determining sequence variants using ultra-deep sequencing
CN101146907B (zh) 2005-04-12 2015-04-08 金克克国际有限公司 蛋白质生产被改变的基因失活突变体
CN101238221B (zh) * 2005-04-12 2011-11-16 Novia公司名下的现场Rcp公司 新型环形探针及其在鉴定生物分子中的用途
US8080393B2 (en) * 2005-04-12 2011-12-20 Olink Ab Methods for production of oligonucleotides
US20060228721A1 (en) * 2005-04-12 2006-10-12 Leamon John H Methods for determining sequence variants using ultra-deep sequencing
DK1889920T3 (da) 2005-04-13 2010-05-10 Consejo Superior Investigacion In vitro fremgangsmåde atil identifikation af forbindelse atil cancerterapi
WO2006109085A1 (en) 2005-04-13 2006-10-19 Astex Therapeutics Limited Hydroxybenzamide derivatives and their use as inhibitors of hsp90
CA2605158A1 (en) 2005-04-14 2006-10-26 The Trustees Of Boston University Diagnostic for lung disorders using class prediction
WO2006113709A2 (en) 2005-04-15 2006-10-26 Del Monte Fresh Produce Company Plant promoters, terminators, genes, vectors and related transformed plants
CA2604580A1 (en) 2005-04-15 2006-10-26 President And Fellows Of Harvard College Methods for modulating bone formation and mineralization by modulating krc activity
EP2360181B1 (en) 2005-04-18 2013-09-18 Novo Nordisk A/S IL-21 variants
US7959929B2 (en) 2005-04-21 2011-06-14 University Of Florida Research Foundation, Inc. Materials and methods for respiratory disease control in canines
US11865172B2 (en) 2005-04-21 2024-01-09 University Of Florida Research Foundation, Inc. Materials and methods for respiratory disease control in canines
AU2006240038B2 (en) 2005-04-21 2012-07-05 Cornell Research Foundation, Inc. Materials and methods for respiratory disease control in canines
PA8672101A1 (es) 2005-04-29 2006-12-07 Centocor Inc Anticuerpos anti-il-6, composiciones, métodos y usos
MY148086A (en) * 2005-04-29 2013-02-28 Rinat Neuroscience Corp Antibodies directed against amyloid-beta peptide and methods using same
WO2006119292A2 (en) * 2005-04-29 2006-11-09 Henkin, Robert Methods for detection of biological substances
US8506934B2 (en) 2005-04-29 2013-08-13 Robert I. Henkin Methods for detection of biological substances
WO2006119280A2 (en) * 2005-05-03 2006-11-09 Handylab, Inc. Lyophilized pellets
UA95446C2 (ru) * 2005-05-04 2011-08-10 Іллюміджен Байосайєнсіз, Інк. Мутаци в генах oas1
WO2006119466A2 (en) * 2005-05-04 2006-11-09 Immunotrex Corporation Methods for microorganism detection and identification
US7524660B2 (en) 2005-05-05 2009-04-28 E.I. Du Pont De Nemours And Company Utilization of fructose in microbial production strains
EP1880007A2 (en) 2005-05-05 2008-01-23 Genencor International, Inc. Personal care compositions and methods for their use
US7902352B2 (en) * 2005-05-06 2011-03-08 Medtronic, Inc. Isolated nucleic acid duplex for reducing huntington gene expression
US20060257912A1 (en) * 2005-05-06 2006-11-16 Medtronic, Inc. Methods and sequences to suppress primate huntington gene expression
AU2006244460B2 (en) 2005-05-06 2010-04-08 Gen-Probe Incorporated Compositions and assays to detect influenza virus A and B nucleic acids
EP2385061A3 (en) 2005-05-10 2012-02-22 Neoloch Aps Neuritogenic peptides
US8624027B2 (en) 2005-05-12 2014-01-07 Abbvie Inc. Combination therapy for treating cancer and diagnostic assays for use therein
US20060286584A1 (en) * 2005-05-12 2006-12-21 Board Of Regents, The University Of Texas System Compositions and methods for the regulation of cell proliferation and apoptosis
WO2006122401A1 (en) * 2005-05-16 2006-11-23 Institut De Recherches Cliniques De Montreal/I.R.C.M. Negative regulation of nk cell functions by eat-2, a sap-related adaptor expressed in innate immune cells
AU2006246975B2 (en) 2005-05-17 2011-08-11 Ozgene Pty Ltd Sequential cloning system
EP3805245A1 (en) 2005-05-17 2021-04-14 University of Connecticut Compositions and methods for immunomodulation in an organism
AU2006251637B2 (en) * 2005-05-20 2012-06-14 Integrated Dna Technologies, Inc. Compounds and methods for labeling oligonucleotides
CA2618429A1 (en) * 2005-05-25 2007-03-22 Tripep Ab A hepatitis c virus non-structural ns3/4a fusion gene
EP1888034A2 (en) 2005-05-26 2008-02-20 Yissum Research Development Company, of The Hebrew University of Jerusalem Compositions and methods using same for delivering agents into a target organ protected by a blood barrier
PT1885176T (pt) 2005-05-27 2016-11-28 Monsanto Technology Llc Evento mon89788 de soja e métodos para a sua deteção
US20090087841A1 (en) * 2005-05-27 2009-04-02 Monogram Biosciences, Inc. Methods and compositions for determining resistance of hiv-1 to protease inhibitors
US20090130666A1 (en) * 2005-05-27 2009-05-21 Applera Corporation Cytometric system including nucleic acid sequence amplification, and method
FR2886735B1 (fr) * 2005-06-01 2015-09-11 Biomerieux Sa Procede de marquage ou de traitement d'un echantillon biologique contenant des molecules biologiques d'interet, notamment des acides nucleiques
WO2006133266A2 (en) 2005-06-06 2006-12-14 Monogram Biosciences, Inc. Methods for determining resistance or susceptibility to hiv entry inhibitors
WO2006133267A2 (en) 2005-06-06 2006-12-14 Monogram Biosciences, Inc. Methods and compositions for determining altered susceptibility of hiv-1 to anti-hiv drugs
EP1893777B1 (en) 2005-06-07 2014-10-01 Luminex Corporation Methods for detection and typing of nucleic acids
ES2401485T3 (es) 2005-06-09 2013-04-22 Glaxosmithkline Llc Método de identificación de compuestos que se unen a una molécula diana biológica
CA2611743C (en) 2005-06-15 2019-12-31 Callida Genomics, Inc. Nucleic acid analysis by forming and tracking aliquoted fragments of a target polynucleotide
ES2524996T3 (es) 2005-06-16 2014-12-16 Ramot At Tel Aviv University Ltd. Células aisladas y poblaciones que comprenden a las mismas para el tratamiento de enfermedades del SNC
WO2006136621A1 (es) 2005-06-16 2006-12-28 Biotools Biotechnological & Medical Laboratories, S.A. Método de detección de ácidos nucleicos mediante generación directa de una señal medible
BRPI0612301A2 (pt) * 2005-06-20 2009-01-27 Decode Genetics Ehf mÉtodo para diagnosticar uma suscetibilidade para a diabete tipo ii em um indivÍduo, kit, e, mÉtodo para avaliar um indivÍduo quanto a probabilidade de resposta a um agente terapÊutico de tcf7l2
US20070225242A1 (en) * 2005-06-21 2007-09-27 The Board Of Trustees Of The Leland Stanford Junior University Method and composition for treating and preventing tumor metastasis in vivo
US20060286006A1 (en) * 2005-06-21 2006-12-21 Mcdaniel C S Method and apparatus for the treatment of fluid waste streams
US20060292559A1 (en) * 2005-06-23 2006-12-28 Beckman Coulter, Inc. Cell-based microarrays, and methods for their preparation and use
US20110045991A1 (en) * 2005-06-23 2011-02-24 Sadanand Gite Methods for the Detection of Colorectal Cancer
US7868159B2 (en) 2005-06-23 2011-01-11 Baylor College Of Medicine Modulation of negative immune regulators and applications for immunotherapy
US9133517B2 (en) * 2005-06-28 2015-09-15 Medtronics, Inc. Methods and sequences to preferentially suppress expression of mutated huntingtin
WO2007002904A2 (en) * 2005-06-28 2007-01-04 Medtronic, Inc. Methods and sequences to preferentially suppress expression of mutated huntingtin
US7645866B2 (en) * 2005-06-28 2010-01-12 Life Technologies Corporation Methods of producing and sequencing modified polynucleotides
EP1896073B1 (en) 2005-06-30 2013-03-06 Janssen Biotech, Inc. Anti-il-23 antibodies, compositions, methods and uses
US20070015191A1 (en) * 2005-07-01 2007-01-18 Promega Corporation Network of buoyant particles for biomolecule purification and use of buoyant particles or network of buoyant particles for biomolecule purification
WO2007007317A1 (en) * 2005-07-07 2007-01-18 Yissum Research Development Company Of The Hebrew University Of Jerusalem Nucleic acid agents for downregulating h19, and methods of using same
US8785130B2 (en) * 2005-07-07 2014-07-22 Bio-Id Diagnostic Inc. Use of markers including nucleotide sequence based codes to monitor methods of detection and identification of genetic material
WO2007006091A1 (en) 2005-07-07 2007-01-18 Athlomics Pty Ltd Polynucleotide marker genes and their expression, for diagnosis of endotoxemia
RU2008104637A (ru) * 2005-07-07 2009-08-20 Даниско А/С (Dk) Модифицированная амилаза из pseudomonas saccharophilia
JP5086254B2 (ja) 2005-07-07 2012-11-28 フルクルム エスピー リミテッド Ｓｐ１ポリペプチド、変性ｓｐ１ポリペプチドおよびそれらの使用
US8030050B2 (en) * 2005-07-07 2011-10-04 Danisco A/S Modified amylases from Pseudomonas species
WO2007008708A2 (en) * 2005-07-08 2007-01-18 Ohio University Methods of predicting hyp-glycosylation sites for proteins expressed and secreted in plant cells, and related methods and products
US7815926B2 (en) 2005-07-11 2010-10-19 Musculoskeletal Transplant Foundation Implant for articular cartilage repair
US7494788B2 (en) 2005-07-11 2009-02-24 Molecular Kinetics, Inc. Entropic bristle domain sequences and their use in recombinant protein production
WO2007011722A2 (en) 2005-07-15 2007-01-25 President And Fellows Of Harvard College Reaction discovery system
CN101278052A (zh) 2005-07-18 2008-10-01 普罗塔里克斯有限公司 生物活性大分子的粘膜或肠给药
GB0514910D0 (en) 2005-07-20 2005-08-24 Solexa Ltd Method for sequencing a polynucleotide template
GB0514935D0 (en) 2005-07-20 2005-08-24 Solexa Ltd Methods for sequencing a polynucleotide template
AU2006272776B2 (en) 2005-07-21 2012-01-19 Ibis Biosciences, Inc. Methods for rapid identification and quantitation of nucleic acid variants
US20070026444A1 (en) * 2005-07-27 2007-02-01 Allan Heff Thermal cycling in polymerase chain reactions by thermodynamic methods
EP1748081A1 (en) 2005-07-28 2007-01-31 Roche Diagnostics GmbH Analytical method and device
US7892795B2 (en) 2005-08-02 2011-02-22 Focus Diagnostics, Inc. Methods and compositions for detecting BK virus
CN1908189A (zh) * 2005-08-02 2007-02-07 博奥生物有限公司 体外辅助鉴定肠型胃癌及其分化程度的方法与专用试剂盒
KR101446025B1 (ko) * 2005-08-03 2014-10-01 아이바이오, 인크. 면역글로불린의 생산을 위한 조성물 및 방법
CA2615460A1 (en) * 2005-08-08 2007-02-15 Onconon, Llc Antibody compositions, methods for treating neoplastic disease and methods for regulating fertility
AU2006279420B2 (en) * 2005-08-16 2010-12-16 Merlogen, Llc Methods for identification of merle gene
WO2007020256A1 (en) 2005-08-16 2007-02-22 Novo Nordisk A/S Method for making mature insulin polypeptides
US7838646B2 (en) * 2005-08-18 2010-11-23 Quest Diagnostics Investments Incorporated Cystic fibrosis transmembrane conductance regulator gene mutations
US20070202512A1 (en) * 2005-08-19 2007-08-30 Bristol-Myers Squibb Company Human single nucleotide polymorphisms associated with dose-dependent weight gain and methods of use thereof
EP1917347B1 (en) 2005-08-22 2015-10-07 Cornell Research Foundation, Inc. Compositions and methods for analyzing protein interactions
EP1928479B1 (en) 2005-08-24 2016-06-08 Yeda Research And Development Co., Ltd. Universal donor-derived tolerogenic cells for inducing non-syngeneic transplantation tolerance
US7666593B2 (en) 2005-08-26 2010-02-23 Helicos Biosciences Corporation Single molecule sequencing of captured nucleic acids
EP2325332B1 (en) 2005-08-26 2012-10-31 DuPont Nutrition Biosciences ApS Use of CRISPR associated genes (CAS)
PT1917276T (pt) 2005-08-26 2018-06-11 Ares Trading Sa Processo para a preparação de interferão beta glicosilado
US8476070B2 (en) 2005-08-29 2013-07-02 Technion Research & Development Foundation Limited Media for culturing stem cells
JP4891580B2 (ja) * 2005-08-31 2012-03-07 株式会社東芝 不揮発性半導体記憶装置
WO2007028147A2 (en) * 2005-09-01 2007-03-08 Philadelphia Health & Education Corporation D.B.A. Drexel University College Of Medicin Identification of a prostatic intraepithelial neoplasia (pin)-specific gene and protein (pin-1) useful as a diagnostic treatment for prostate cancer
JP2009506759A (ja) * 2005-09-01 2009-02-19 コーベット ライフ サイエンス ピーティーワイ リミテッド 核酸の増幅、定量化、及び同定の方法。
CA2621146A1 (en) * 2005-09-06 2007-03-15 Gen-Probe Incorporated Methods, compositions and kits for isothermal amplification of nucleic acids
KR20090004839A (ko) * 2005-09-07 2009-01-12 제네렉스, 인코포레이티드 Ｇｍ-ｃｓｆ를 발현하는 폭스바이러스를 사용한 전이성및/또는 전신 파종성 암의 전신 치료법
US8980246B2 (en) 2005-09-07 2015-03-17 Sillajen Biotherapeutics, Inc. Oncolytic vaccinia virus cancer therapy
US7569367B2 (en) 2005-09-07 2009-08-04 Roche Diagnostics Operations, Inc. Nucleic acid preparation from whole blood for use in diagnosis of transmissible spongiform encephalopathy
CA2621267A1 (en) 2005-09-07 2007-03-15 Nugen Technologies, Inc. Improved nucleic acid amplification procedure
US8193328B2 (en) * 2005-09-08 2012-06-05 Philadelphia Health & Education Corporation Identification of modulators of serine protease inhibitor Kazal and their use as anti-cancer and anti-viral agents
EP1762627A1 (de) * 2005-09-09 2007-03-14 Qiagen GmbH Verfahren zur Aktivierung einer Nukleinsäure für eine Polymerase-Reaktion
US20070059713A1 (en) * 2005-09-09 2007-03-15 Lee Jun E SSB-DNA polymerase fusion proteins
CA2622295C (en) 2005-09-12 2019-01-15 The Regents Of The University Of Michigan Recurrent gene fusions in prostate cancer
US9957569B2 (en) * 2005-09-12 2018-05-01 The Regents Of The University Of Michigan Recurrent gene fusions in prostate cancer
US20090055942A1 (en) 2005-09-14 2009-02-26 Novo Nordisk Healthcare A/G Human Coagulation Factor VII Polypeptides
US7608395B2 (en) 2005-09-15 2009-10-27 Baylor Research Institute Systemic lupus erythematosus diagnostic assay
US20070065834A1 (en) * 2005-09-19 2007-03-22 Hillis William D Method and sequences for determinate nucleic acid hybridization
AU2006292224B2 (en) 2005-09-19 2013-08-01 Histogenics Corporation Cell-support matrix and a method for preparation thereof
ES2374450T3 (es) 2005-09-20 2012-02-16 OSI Pharmaceuticals, LLC Marcadores biológicos predictivos de respuesta anticancerígena para inhibidores de cinasa del receptor del factor de crecimiento 1 similar a insulina.
DE602006014009D1 (de) 2005-09-22 2010-06-10 Yissum Res Dev Co Nukleinsäure konstrukten, pharmazeutische kompositionen und methoden für die behandlung von krebs
US7799530B2 (en) 2005-09-23 2010-09-21 Celera Corporation Genetic polymorphisms associated with cardiovascular disorders and drug response, methods of detection and uses thereof
US9297028B2 (en) 2005-09-29 2016-03-29 Butamax Advanced Biofuels Llc Fermentive production of four carbon alcohols
IL172297A (en) 2005-10-03 2016-03-31 Compugen Ltd Soluble vegfr-1 variants for the diagnosis of preeclampsia
AU2006302022A1 (en) * 2005-10-06 2007-04-19 University Of Delaware G-rich polynucleotides for the treatment of Huntington's Disease
EP1934339B1 (en) 2005-10-06 2011-12-14 Lucigen Corporation Thermostable viral polymerases and methods of use
CA2625263C (en) 2005-10-07 2016-12-13 Johnson & Johnson Research Pty Limited Multicomponent nucleic acid enzymes and methods for their use
EP1951900B1 (en) 2005-10-07 2016-06-15 Callida Genomics, Inc. Self-assembled single molecule arrays and uses thereof
US7838221B2 (en) 2005-10-11 2010-11-23 Geneohm Sciences, Inc. Sequences for detection and identification of methicillin-resistant Staphylococcus aureus (MRSA)
US11834720B2 (en) 2005-10-11 2023-12-05 Geneohm Sciences, Inc. Sequences for detection and identification of methicillin-resistant Staphylococcus aureus (MRSA) of MREJ types xi to xx
US8831887B2 (en) 2005-10-12 2014-09-09 The Research Foundation For The State University Of New York Absolute PCR quantification
US20080293610A1 (en) * 2005-10-12 2008-11-27 Andrew Shaw Use and production of storage-stable neutral metalloprotease
EP1945778B1 (en) * 2005-10-17 2012-12-26 MedImmune, LLC Methods of increasing influenza virus replication
JP2009511086A (ja) 2005-10-17 2009-03-19 ジェン−プローブ・インコーポレーテッド レジオネラ・ニューモフィラ核酸を検出するための組成物及び方法
EP1777523A1 (en) 2005-10-19 2007-04-25 INSERM (Institut National de la Santé et de la Recherche Médicale) An in vitro method for the prognosis of progression of a cancer and of the outcome in a patient and means for performing said method
MX2007015931A (es) 2005-10-20 2008-04-22 Senomyx Inc Receptores de sabor dulce-umami y umami-dulce humanos quimericos.
BRPI0618965B1 (pt) 2005-10-24 2021-01-12 Evogene Ltd método para aumentar a tolerância de uma planta a uma condição de estresse abiótico, método para aumentar a biomassa, vigor e/ou rendimento de uma planta, método para aumentar a eficiência do uso de fertilizante e/ou absorção de uma planta
EP1951903A2 (en) * 2005-10-25 2008-08-06 Interleukin Genetics, Inc. The il-1 gene cluster and associated inflammatory polymorphisms and haplotypes
NZ593809A (en) 2005-10-26 2013-01-25 Butamax Tm Advanced Biofuels Fermentive production of four carbon alcohols
US20080274526A1 (en) 2007-05-02 2008-11-06 Bramucci Michael G Method for the production of isobutanol
US8945899B2 (en) 2007-12-20 2015-02-03 Butamax Advanced Biofuels Llc Ketol-acid reductoisomerase using NADH
US7695911B2 (en) 2005-10-26 2010-04-13 Celera Corporation Genetic polymorphisms associated with Alzheimer's Disease, methods of detection and uses thereof
US8956850B2 (en) 2008-06-05 2015-02-17 Butamax Advanced Biofuels Llc Enhanced pyruvate to acetolactate conversion in yeast
US8273558B2 (en) 2005-10-26 2012-09-25 Butamax(Tm) Advanced Biofuels Llc Fermentive production of four carbon alcohols
WO2007053358A2 (en) 2005-10-28 2007-05-10 Praecis Pharmaceuticals, Inc. Methods for identifying compounds of interest using encoded libraries
DK2484202T3 (en) 2005-10-28 2017-09-11 Dow Agrosciences Llc NEW HERBICID RESISTANCE GENES
GB0522310D0 (en) 2005-11-01 2005-12-07 Solexa Ltd Methods of preparing libraries of template polynucleotides
BRPI0618085A2 (pt) 2005-11-01 2011-08-16 Abbott Biotech Ltd processos e kits para diagnóstico de espondilite ancilosante usando biomarcadores
AU2006308765B2 (en) 2005-11-02 2013-09-05 Arbutus Biopharma Corporation Modified siRNA molecules and uses thereof
JP2009514549A (ja) 2005-11-07 2009-04-09 シーメンス・ヘルスケア・ダイアグノスティックス・インコーポレーテッド Ｃｈｌａｍｙｄｉａｔｒａｃｈｏｍａｔｉｓ特異的オリゴヌクレオチド配列
US20080039393A1 (en) * 2005-11-09 2008-02-14 Desmond Mascarenhas Metal-binding therapeutic peptides
US7662624B2 (en) 2005-11-09 2010-02-16 Ontherix, Inc. Metal-binding therapeutic peptides
US7611893B2 (en) 2005-11-09 2009-11-03 Ontherix, Inc. Metal-binding therapeutic peptides
EP1945263A4 (en) * 2005-11-09 2012-09-26 Ontherix Inc THERAPEUTIC PEPTIDES BINDING TO METALS
AU2006315562C1 (en) 2005-11-12 2013-10-03 The Board Of Trustees Of The Leland Stanford Junior University Methods for treating depression using NCAM peptide mimetics
SI3045182T1 (en) 2005-11-14 2018-08-31 Teva Pharmaceuticals International Gmbh An antibody to a peptide-associated peptide antagonist to calcitonin for treating a headache in aggregates
WO2007120208A2 (en) * 2005-11-14 2007-10-25 President And Fellows Of Harvard College Nanogrid rolling circle dna sequencing
US8936945B2 (en) * 2005-11-17 2015-01-20 The Regents Of The University Of Michigan Compositions and methods for liquid metering in microchannels
US20080280328A1 (en) 2005-11-18 2008-11-13 Novozymes A/S Glucoamylase Variants
EP1960538A2 (en) * 2005-11-18 2008-08-27 Bioline Limited A method for enhancing enzymatic dna polymerase reactions
GB2432366B (en) * 2005-11-19 2007-11-21 Alligator Bioscience Ab A method for in vitro molecular evolution of protein function
EP1957541A2 (en) * 2005-11-21 2008-08-20 Laboratoires Serono SA Compositions and methods of producing hybrid antigen binding molecules and uses thereof
EP1969137B1 (en) 2005-11-22 2011-10-05 Stichting Dienst Landbouwkundig Onderzoek Multiplex nucleic acid detection
EP1957641A2 (en) 2005-11-23 2008-08-20 E.I. Du Pont De Nemours And Company Delta-9 elongases and their use in making polyunsaturated fatty acids
US20090068643A1 (en) * 2005-11-23 2009-03-12 Integrated Dna Technologies, Inc. Dual Function Primers for Amplifying DNA and Methods of Use
GB0524069D0 (en) 2005-11-25 2006-01-04 Solexa Ltd Preparation of templates for solid phase amplification
FR2902430B1 (fr) 2005-11-25 2012-11-02 Biomerieux Sa Oligonucleotides, utilisation, methode de detection et kit permettant de diagnostiquer la presence des genes h5 et n1 du virus d'influenza a
US7579005B2 (en) * 2005-11-28 2009-08-25 E. I. Du Pont De Nemours And Company Process for recombinant expression and purification of antimicrobial peptides using periplasmic targeting signals as precipitable hydrophobic tags
CN103710430B (zh) 2005-11-29 2016-03-30 剑桥企业有限公司 乳腺癌标志物
US8846393B2 (en) 2005-11-29 2014-09-30 Gamida-Cell Ltd. Methods of improving stem cell homing and engraftment
EP1954718B1 (en) 2005-11-30 2014-09-03 AbbVie Inc. Anti-a globulomer antibodies, antigen-binding moieties thereof, corresponding hybridomas, nucleic acids, vectors, host cells, methods of producing said antibodies, compositions comprising said antibodies, uses of said antibodies and methods of using said antibodies
US20070237716A1 (en) * 2005-11-30 2007-10-11 Mason Andrew L Compositions and methods for reverse transcriptase-polymerase chain reaction (rt-pcr) of human b-retrovirus
PT1976877E (pt) 2005-11-30 2014-04-29 Abbvie Inc Anticorpos monoclonais contra proteína beta-amilóide e suas utilizações
ES2901551T3 (es) 2005-12-01 2022-03-22 Nuevolution As Métodos de codificación enzimática para la síntesis eficiente de bibliotecas grandes
NZ568016A (en) 2005-12-07 2011-12-22 Medarex Inc CTLA-4 antibody dosage escalation regimens
CN101365808B (zh) * 2005-12-07 2012-04-25 泰博特克药品有限公司 用于评估hiv病毒适应度的方法、质粒载体和引物
WO2007070381A2 (en) 2005-12-09 2007-06-21 Promega Corporation Nucleic acid purification with a binding matrix
WO2007070642A2 (en) * 2005-12-15 2007-06-21 Helicos Biosciences Corporation Methods for increasing accuracy of nucleic acid sequencing
EP2674440B1 (en) 2005-12-16 2019-07-03 IBC Pharmaceuticals, Inc. Multivalent immunoglobulin-based bioactive assemblies
EP1798650A1 (en) 2005-12-19 2007-06-20 Roche Diagnostics GmbH Analytical method and instrument
EP1798542A1 (en) 2005-12-19 2007-06-20 Roche Diagnostics GmbH Analytical method and instrument
KR100652903B1 (ko) * 2005-12-21 2006-12-04 한국과학기술연구원 초흡수성 고분자를 함유한 제습제의 제조 방법 및 그 제조장치
US8313901B2 (en) * 2005-12-21 2012-11-20 Yale University Methods and compositions related to the modulation of riboswitches
US7981606B2 (en) * 2005-12-21 2011-07-19 Roche Molecular Systems, Inc. Control for nucleic acid testing
WO2007076493A2 (en) 2005-12-23 2007-07-05 Siemens Healthcare Diagnostics Inc. Methods and reagents for genotyping hcv
EP1976567B1 (en) 2005-12-28 2020-05-13 The Scripps Research Institute Natural antisense and non-coding rna transcripts as drug targets
EP1969004B1 (en) 2005-12-28 2011-08-10 Novo Nordisk A/S Compositions comprising an acylated insulin and zinc and method of making the said compositions
HUE049832T2 (hu) 2005-12-29 2020-10-28 Janssen Biotech Inc Humán anti-IL-23 ellenanyagok, készítmények, eljárás és alkalmazások
US20080118914A1 (en) * 2006-01-04 2008-05-22 Charlotte Dawn Blowe Follistatin gene as a genetic marker for first parity litter size in pigs
WO2007081841A2 (en) 2006-01-06 2007-07-19 Stratagene California Reaction buffer composition for nucleic acid replication with packed dna polymerases
GB0600228D0 (en) 2006-01-06 2006-02-15 Fermentas Uab Inactivation method
WO2007081385A2 (en) 2006-01-11 2007-07-19 Raindance Technologies, Inc. Microfluidic devices and methods of use in the formation and control of nanoreactors
WO2007080129A1 (en) 2006-01-13 2007-07-19 A Chan Holding B.V. Treatment and diagnosis of abnormal bone density with an inhibitor of the glypican-sclerostin interaction
EP1982450A2 (en) * 2006-01-16 2008-10-22 Zlango Ltd. Communications network system and methods for using same
EP1973945A4 (en) 2006-01-16 2009-11-18 Compugen Ltd NEW NUCLEOTIDE AND AMINO ACID SEQUENCES AND METHOD FOR THEIR APPLICATION IN DIAGNOSIS
CA2637600A1 (en) 2006-01-17 2007-07-26 Health Research, Inc. Heteroduplex tracking assay
WO2008019162A2 (en) 2006-01-18 2008-02-14 University Of Chicago Compositions and methods related to staphylococcal bacterium proteins
AU2007282135C1 (en) * 2006-01-18 2012-05-24 Coimmune, Inc. Systems and methods for processing samples in a closed container, and related devices
US20100070184A1 (en) * 2006-01-19 2010-03-18 Monogram Biosciences, Inc. Method for determining resistance of hiv to protease inhibitor treatment
KR20080094803A (ko) 2006-01-27 2008-10-24 트리패스 이미징, 인코포레이티드 난소암의 발병 가능성이 높은 환자를 확인하는 방법 및 그의 조성물
EP1987142A4 (en) 2006-02-02 2009-07-15 Verenium Corp ESTERASES AND ASSOCIATED NUCLEIC ACIDS AND METHODS
CN101517417B (zh) * 2006-02-02 2012-07-18 考贝特生命科学控股有限公司 热循环器和加样口
US9249407B2 (en) 2006-02-03 2016-02-02 Opko Biologics Ltd. Long-acting coagulation factors and methods of producing same
US8759292B2 (en) 2006-02-03 2014-06-24 Prolor Biotech, Llc Long-acting coagulation factors and methods of producing same
US8048849B2 (en) 2006-02-03 2011-11-01 Modigene, Inc. Long-acting polypeptides and methods of producing same
US20140113860A1 (en) 2006-02-03 2014-04-24 Prolor Biotech Ltd. Long-acting polypeptides and methods of producing and administering same
US9458444B2 (en) 2006-02-03 2016-10-04 Opko Biologics Ltd. Long-acting coagulation factors and methods of producing same
US8048848B2 (en) 2006-02-03 2011-11-01 Prolor Biotech Ltd. Long-acting interferons and derivatives thereof and methods thereof
US10351615B2 (en) 2006-02-03 2019-07-16 Opko Biologics Ltd. Methods of treatment with long-acting growth hormone
WO2007092252A2 (en) 2006-02-03 2007-08-16 Modigene Inc Long-acting polypeptides and methods of producing same
US10221228B2 (en) 2006-02-03 2019-03-05 Opko Biologics Ltd. Long-acting polypeptides and methods of producing and administering same
US8946155B2 (en) 2006-02-03 2015-02-03 Opko Biologics Ltd. Long-acting polypeptides and methods of producing and administering same
US8450269B2 (en) 2006-02-03 2013-05-28 Prolor Biotech Ltd. Long-acting growth hormone and methods of producing same
US20150038413A1 (en) 2006-02-03 2015-02-05 Opko Biologics Ltd. Long-acting polypeptides and methods of producing and administering same
US8476234B2 (en) 2006-02-03 2013-07-02 Prolor Biotech Inc. Long-acting coagulation factors and methods of producing same
JP2009526219A (ja) 2006-02-06 2009-07-16 ラパポート ファミリー インスティテュート フォー リサーチ イン ザ メディカル サイエンシーズ Ｔ１ｄｍを診断するための方法及びキット
WO2007092538A2 (en) 2006-02-07 2007-08-16 President And Fellows Of Harvard College Methods for making nucleotide probes for sequencing and synthesis
WO2007092944A2 (en) * 2006-02-08 2007-08-16 Introgen Therapeutics, Inc. Compositions and methods involving gene therapy and proteasome modulation
DK1987159T4 (da) 2006-02-08 2020-11-16 Illumina Cambridge Ltd Fremgangsmåde til sekventering af en polynukleotidtemplate
US20070190828A1 (en) * 2006-02-10 2007-08-16 Bio-Rad Laboratories, Inc. Method for substantially preventing contamination of electrical contacts
NZ595499A (en) 2006-02-10 2013-05-31 Verenium Corp Cellulolytic enzymes, nucleic acids encoding them and methods for making and using them
EP3018215B1 (en) 2006-02-13 2019-01-30 Fluidigm Canada Inc. Gene expression assays conducted by elemental analysis
US8277816B2 (en) * 2006-02-13 2012-10-02 Fraunhofer Usa, Inc. Bacillus anthracis antigens, vaccine compositions, and related methods
EP1989228B1 (en) 2006-02-14 2015-04-29 University Of Tasmania Through The Menzies Research Institute Metallothionein-derived peptide fragments
US8043839B2 (en) 2006-02-14 2011-10-25 Verenium Corporation Xylanases, nucleic acids encoding them and methods for making and using them
JP5441416B2 (ja) * 2006-02-14 2014-03-12 プレジデント アンド フェロウズ オブ ハーバード カレッジ 二官能性ヒストンデアセチラーゼインヒビター
US20090221072A1 (en) * 2006-02-15 2009-09-03 Chen Thomas T Compositions and methods for modulating cell differentiation
CN107446033B (zh) 2006-02-22 2022-04-01 朱正崙 发育相关疾病的治疗
WO2007096182A1 (en) * 2006-02-27 2007-08-30 Roche Diagnostics Gmbh Pcr hot start by magnesium sequestration
US8198040B2 (en) 2006-02-28 2012-06-12 Montana State University Use of phenanthridium derivatives for distinguishing between live and dead cells
CA2644475A1 (en) * 2006-03-01 2007-09-07 Perlegen Sciences, Inc. Markers for addiction
CA2641954C (en) 2006-03-06 2016-04-26 Zetiq Technologies Ltd. Methods and compositions for identifying a cell phenotype
EA029538B1 (ru) 2006-03-07 2018-04-30 Басф Энзаймс Ллк Полипептид, обладающий активностью альдолазы, полинуклеотид, кодирующий этот полипептид, и способы получения и применения полинуклеотида и полипептида
CN101437954B (zh) 2006-03-07 2015-09-09 嘉吉公司 醛缩酶和编码醛缩酶的核酸以及它们的制备和使用方法
US20090061454A1 (en) 2006-03-09 2009-03-05 Brody Jerome S Diagnostic and prognostic methods for lung disorders using gene expression profiles from nose epithelial cells
US20090061450A1 (en) * 2006-03-14 2009-03-05 Micronics, Inc. System and method for diagnosis of infectious diseases
EP2007905B1 (en) * 2006-03-15 2012-08-22 Micronics, Inc. Integrated nucleic acid assays
GB0605689D0 (en) * 2006-03-21 2006-05-03 Novartis Ag Organic compounds
CA2647107A1 (en) 2006-03-23 2007-09-27 Novartis Ag Anti-tumor cell antigen antibody therapeutics
SG170761A1 (en) 2006-03-23 2011-05-30 Pluristem Ltd Methods for cell expansion and uses of cells and conditioned media produced thereby for therapy
US10900066B2 (en) 2006-03-24 2021-01-26 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
EP2001990B1 (en) 2006-03-24 2016-06-29 Handylab, Inc. Integrated system for processing microfluidic samples, and method of using same
US8883490B2 (en) 2006-03-24 2014-11-11 Handylab, Inc. Fluorescence detector for microfluidic diagnostic system
US7998708B2 (en) 2006-03-24 2011-08-16 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
WO2007110869A2 (en) 2006-03-28 2007-10-04 Tel Hashomer Medical Research Infrastructure And Services Ltd. Methods and kits for determining predisposition to warfarin resistance
EP3167900B1 (en) 2006-03-29 2018-11-21 Merial Limited Vaccine against streptococci
WO2007126975A2 (en) 2006-03-31 2007-11-08 The Govt. Of The Usa, As Represented By The Secretary, Dept. Of Health & Human Services, A newly discovered bacterium in the family acetobacteraceae
US20070231805A1 (en) * 2006-03-31 2007-10-04 Baynes Brian M Nucleic acid assembly optimization using clamped mismatch binding proteins
US7537917B2 (en) * 2006-03-31 2009-05-26 Collins Michael J Microwave assisted PCR amplification of DNA
WO2008051285A2 (en) * 2006-04-01 2008-05-02 Medical Service Consultation International, Llc Methods and compositions for detecting fungi and mycotoxins
EP2002013A4 (en) 2006-04-04 2010-05-05 Labonnet Ltd ASSESSMENT OF REACTION KINETICS COMPATIBILITY BETWEEN POLYMERASE CHAIN REACTIONS
US7741469B2 (en) * 2006-04-05 2010-06-22 University Of Iowa Research Foundation Compositions for treating hearing loss and methods of use thereof
CA2638782C (en) 2006-04-07 2020-08-25 Siemens Healthcare Diagnostics Inc. Neisseria gonorrhoeae pivng gene specific oligonucleotide sequences
US20070264694A1 (en) * 2006-04-07 2007-11-15 Eragen Biosciences, Inc. Use of non-standard bases and proximity effects for gene assembly and conversion of non-standard bases to standard bases during dna synthesis
US7285388B1 (en) * 2006-04-07 2007-10-23 Merlogen, Llc Methods for identification of alport syndrome
KR20090029184A (ko) * 2006-04-07 2009-03-20 더 가브먼트 오브 더 유나이티드 스테이츠 오브 아메리카, 리프리젠티드 바이 더 세크러테리, 디파트먼트 오브 헬쓰 앤드 휴먼 서비씨즈 항체 조성물 및 신생물성 질병의 치료 방법
EP2010226B1 (en) 2006-04-07 2014-01-15 The Research Foundation of State University of New York Transcobalamin receptor polypeptides, nucleic acids, and modulators thereof, and related methods of use in modulating cell growth and treating cancer and cobalamin deficiency
US20070238095A1 (en) * 2006-04-11 2007-10-11 Mayo Foundation For Medical Education And Research , A Minnesota Corporation Detection of Influenza A Virus
US20070238093A1 (en) * 2006-04-11 2007-10-11 Espy Mark J Detection of influenza A virus
AU2007240448B8 (en) 2006-04-19 2014-03-06 Medimmune Llc. Methods and compositions for expressing negative-sense viral RNA in canine cells
JP2009538123A (ja) * 2006-04-19 2009-11-05 アプライド バイオシステムズ， エルエルシー ゲル非含有ビーズベースの配列決定のための試薬、方法およびライブラリー
US7465793B2 (en) 2006-04-20 2008-12-16 E.I. Du Pont De Nemours And Company Synthetic Δ17 desaturase derived from Phytophthora ramourum and its use in making polyunsaturated fatty acids
CA2649535A1 (en) 2006-04-20 2007-11-01 Becton, Dickinson And Company Thermostable proteins and methods of making and using thereof
CA2646309C (en) 2006-04-21 2016-07-26 Nanobiosym, Inc. Single-molecule platform for drug discovery: methods and apparatuses for drug discovery, including discovery of anticancer and antiviral agents
KR101387563B1 (ko) 2006-04-21 2014-04-25 세노믹스, 인코포레이티드 고효능의 조미용 향료를 포함하는 식품 조성물 및 이의 제조 방법
EP2020449B1 (en) 2006-04-24 2012-09-26 Sigma Alimentos, S.A. De C.V. Method for detection and multiple, simultaneous quantification of pathogens by means of real-time polymerase chain reaction
US8492097B2 (en) 2006-04-24 2013-07-23 Diagnostic Hybrids, Inc. Compositions and methods for human metapneumovirus monoclonal antibodies
ES2878130T3 (es) 2006-04-25 2021-11-18 Astex Therapeutics Ltd Derivados de purina y deazapurina como compuestos farmacéuticos
FR2900158A1 (fr) 2006-04-25 2007-10-26 Biomerieux Sa Nouvelle sonde de detection agissant par reconnaissance moleculaire
US8933209B2 (en) * 2006-04-26 2015-01-13 Abbvie Inc. Dep2 and its uses in major depressive disorder and other related disorders
US20070256148A1 (en) * 2006-04-26 2007-11-01 Katz David A DEP2 and its uses in major depressive disorder and other related disorders
WO2007125330A1 (en) 2006-04-26 2007-11-08 Cancer Research Technology Limited Imidazo[4, 5-b]pyridin-2-one and oxazolo[4, 5-b]pyridin-2-one compounds and analogs thereof as cancer therapeutic compounds
US9121056B2 (en) * 2006-04-28 2015-09-01 Igor Kutyavin Use of products of PCR amplification carrying elements of secondary structure to improve PCR-based nucleic acid detection
US8298818B2 (en) * 2006-04-28 2012-10-30 University Of Florida Research Foundation, Inc. Self-complementary adeno-associated virus having a truncated CMV-chicken β-actin promoter
US8900828B2 (en) * 2006-05-01 2014-12-02 Cepheid Methods and apparatus for sequential amplification reactions
US8206970B2 (en) 2006-05-02 2012-06-26 Butamax(Tm) Advanced Biofuels Llc Production of 2-butanol and 2-butanone employing aminobutanol phosphate phospholyase
EP2019674B1 (en) * 2006-05-03 2016-11-23 The President and Fellows of Harvard College Histone deacetylase and tubulin deacetylase inhibitors
EP2024390B1 (en) 2006-05-09 2015-08-19 Novo Nordisk A/S Insulin derivative
BRPI0712041A2 (pt) 2006-05-09 2011-12-27 Novo Nordisk As derivado de insulina
EP2016199A4 (en) * 2006-05-11 2009-12-30 Geneohm Sciences Inc METHODS OF 100% DETECTION OF THE IDENTITY OF A SEQUENCE FOR VARIOUS GENOMES
EP2530168B1 (en) 2006-05-11 2015-09-16 Raindance Technologies, Inc. Microfluidic Devices
US9562837B2 (en) 2006-05-11 2017-02-07 Raindance Technologies, Inc. Systems for handling microfludic droplets
US9074242B2 (en) 2010-02-12 2015-07-07 Raindance Technologies, Inc. Digital analyte analysis
AU2007249286B2 (en) * 2006-05-12 2013-06-13 Gen-Probe Incorporated Compositions and methods to detect enterococci nucleic acid
US8232091B2 (en) * 2006-05-17 2012-07-31 California Institute Of Technology Thermal cycling system
US8106013B2 (en) 2006-05-19 2012-01-31 Georgia Tech Research Corporation ABC transporter ligand GATX1
US7674924B2 (en) * 2006-05-22 2010-03-09 Third Wave Technologies, Inc. Compositions, probes, and conjugates and uses thereof
US20100196336A1 (en) 2006-05-23 2010-08-05 Dongsu Park Modified dendritic cells having enhanced survival and immunogenicity and related compositions and methods
US9273356B2 (en) 2006-05-24 2016-03-01 Medtronic, Inc. Methods and kits for linking polymorphic sequences to expanded repeat mutations
RU2008145084A (ru) 2006-05-24 2010-06-27 Ново Нордиск Хелс Кеа Аг (Ch) Аналоги фактора ix, имеющие пролонгированное время полужизни in vivo
CA2740917C (en) 2006-05-25 2013-01-08 Monsanto Technology Llc A method to identify disease resistant quantitative trait loci in soybean and compositions thereof
US7897747B2 (en) * 2006-05-25 2011-03-01 The Board Of Trustees Of The Leland Stanford Junior University Method to produce single stranded DNA of defined length and sequence and DNA probes produced thereby
MY146612A (en) 2006-05-26 2012-09-14 Amyris Inc Production of isoprenoids
CA2653338C (en) 2006-05-26 2018-04-24 Monsanto Technology, Llc Corn plant and seed corresponding to transgenic event mon89034 and methods for detection and use thereof
EP1862538A1 (en) * 2006-05-29 2007-12-05 IMBA-Institut für Molekulare Biotechnologie GmbH siRNA kinase and methods of use
US20080125333A1 (en) * 2006-05-31 2008-05-29 Antara Biosciences Inc. Devices and kits for detecting one or more target agents
EP3260556B1 (en) * 2006-05-31 2019-07-31 Sequenom, Inc. Methods for the extraction of nucleic acid from a sample
JP5558811B2 (ja) 2006-06-01 2014-07-23 トリリンク バイオテクノロジーズ 核酸増幅のための化学的に修飾されたオリゴヌクレオチドプライマー
US7479550B2 (en) * 2006-06-02 2009-01-20 The Board Of Regents Of The University Of Texas System Amyloid β gene vaccines
KR100785017B1 (ko) 2006-06-05 2007-12-12 삼성전자주식회사 혈액으로부터 핵산을 증폭하는 방법
US11001881B2 (en) 2006-08-24 2021-05-11 California Institute Of Technology Methods for detecting analytes
US20070281883A1 (en) * 2006-06-05 2007-12-06 Hanna Rosenfeld Development of follicle stimulating hormone agonists and antagonists in fish
AU2007257162A1 (en) 2006-06-05 2007-12-13 Cancer Care Ontario Assessment of risk for colorectal cancer
EP1945821B1 (en) 2006-06-06 2011-01-19 Gen-Probe Incorporated Tagged oligonucleotides and their use in nucleic acid amplification methods
NZ572561A (en) * 2006-06-07 2012-05-25 Bioalliance Cv Antibodies recognizing a carbohydrate containing epitope on cd-43 and cea expressed on cancer cells and methods using same
US20080004185A1 (en) * 2006-06-12 2008-01-03 Antara Biosciences Inc. Three dimensional array
WO2007146443A2 (en) * 2006-06-14 2007-12-21 Oldenburg Kevin R Ph D Thermal-cycling devices and methods of using the same
EP2589668A1 (en) 2006-06-14 2013-05-08 Verinata Health, Inc Rare cell analysis using sample splitting and DNA tags
EP2029779A4 (en) 2006-06-14 2010-01-20 Living Microsystems Inc HIGHLY PARALLEL SNP GENOTYPING UTILIZATION FOR FETAL DIAGNOSIS
US8137912B2 (en) 2006-06-14 2012-03-20 The General Hospital Corporation Methods for the diagnosis of fetal abnormalities
US20080050739A1 (en) 2006-06-14 2008-02-28 Roland Stoughton Diagnosis of fetal abnormalities using polymorphisms including short tandem repeats
CA2656313C (en) * 2006-06-19 2018-07-03 Danisco A/S Ps4 exoamylase h307k/r variant
US8119352B2 (en) * 2006-06-20 2012-02-21 Cepheld Multi-stage amplification reactions by control of sequence replication times
KR101486087B1 (ko) * 2006-06-23 2015-01-26 다니스코 유에스 인크. 다수의 특성들을 조작하는 부위 평가 라이브러리를 사용한 서열 및 활성 관계에 대한 체계적 평가
US9150906B2 (en) 2006-06-28 2015-10-06 Bio-Id Diagnostic Inc. Determination of variants produced upon replication or transcription of nucleic acid sequences
US7951995B2 (en) 2006-06-28 2011-05-31 Pioneer Hi-Bred International, Inc. Soybean event 3560.4.3.5 and compositions and methods for the identification and detection thereof
NZ573931A (en) 2006-06-29 2012-03-30 Craig J Venter Inst Inc Polypeptides from neisseria meningitidis
US20080004410A1 (en) * 2006-06-30 2008-01-03 Yu-Chin Lai Hydrophilic macromonomers having alpha,beta-conjugated carboxylic terminal group and medical devices incorporating same
US7642049B2 (en) 2006-06-30 2010-01-05 Bristol-Myers Squibb Company Method for identifying HIV-1 protease inhibitors with reduced metabolic affects through detection of human resistin polymorphisms
KR100790880B1 (ko) * 2006-07-05 2008-01-02 삼성전자주식회사 자성 비드가 결합되어 있는 소수성 다공성 중합체가 벽면에결합되어 있는 마이크로채널 또는 마이크로챔버를포함하는 미세유동장치 및 그를 이용하는 방법
US7972786B2 (en) * 2006-07-07 2011-07-05 Brandeis University Detection and analysis of influenza virus
EP1878803A1 (en) * 2006-07-10 2008-01-16 Wageningen Universiteit Methods of detecting root knot nematodes
EP2471815B1 (en) 2006-07-11 2016-03-30 University Of Medicine And Dentistry Of New Jersey Proteins, nucleic acids encoding the same and associated methods of use
US20080026394A1 (en) * 2006-07-11 2008-01-31 Antara Biosciences Inc. Methods of detecting one or more cancer markers
WO2008008873A2 (en) * 2006-07-14 2008-01-17 Georgia Tech Research Corporation Clc channel ligand
EP1886727A1 (en) 2006-07-14 2008-02-13 Roche Diagnostics GmbH Analytical device
JP2009543862A (ja) 2006-07-14 2009-12-10 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア ガンのバイオマーカーおよびその使用方法
US20080038742A1 (en) * 2006-07-14 2008-02-14 Porter Tom E Genetic polymorphisms associated with body fat
US7915014B2 (en) 2006-07-17 2011-03-29 Brandeis University Specialized oligonucleotides and their use in nucleic acid amplification and detection
CN104232365A (zh) * 2006-07-18 2014-12-24 丹尼斯科美国公司 在宽温度范围内具有活性的蛋白酶变体
US20080027505A1 (en) * 2006-07-26 2008-01-31 G&L Consulting, Llc System and method for treatment of headaches
JP4918409B2 (ja) 2006-07-26 2012-04-18 西川ゴム工業株式会社 核酸配列の増幅方法
US7700756B2 (en) * 2006-07-27 2010-04-20 Southern Illinois University Metabolic primers for the detection of perchlorate-reducing bacteria and methods of use thereof
WO2008014485A2 (en) 2006-07-28 2008-01-31 California Institute Of Technology Multiplex q-pcr arrays
US11525156B2 (en) 2006-07-28 2022-12-13 California Institute Of Technology Multiplex Q-PCR arrays
US7566558B2 (en) 2006-07-28 2009-07-28 Regents Of The University Of Michigan Nucleic acids and polypeptides involved in the production of cryptophycin
JP5635772B2 (ja) 2006-08-01 2014-12-03 ジェン−プロウブ インコーポレイテッド 核酸の非特異的標的の捕捉方法
BRPI0714876B1 (pt) 2006-08-04 2022-04-19 Verenium Corporation Ácido nucleico isolado, sintético ou recombinante, cassete de expressão, vetor ou veículo de clonagem, célula bacteriana, fúngica ou de levedura transformada, polipeptídeo isolado, sintético ou recombinante, composição, bem como métodos de produção e de usos dos mesmos
US9012390B2 (en) 2006-08-07 2015-04-21 Raindance Technologies, Inc. Fluorocarbon emulsion stabilizing surfactants
CA2660286A1 (en) 2006-08-09 2008-02-21 Homestead Clinical Corporation Organ-specific proteins and methods of their use
US20080039415A1 (en) * 2006-08-11 2008-02-14 Gregory Robert Stewart Retrograde transport of sirna and therapeutic uses to treat neurologic disorders
WO2008021431A2 (en) * 2006-08-14 2008-02-21 Xdx, Inc. Methods and compositions for diagnosing and monitoring the status of transplant rejection and immune disorders
AU2007285484B2 (en) 2006-08-16 2013-05-02 Novartis Ag Immunogens from uropathogenic Escherichia coli
US8980561B1 (en) 2006-08-22 2015-03-17 Los Alamos National Security, Llc. Nucleic acid detection system and method for detecting influenza
WO2008105814A2 (en) 2006-08-22 2008-09-04 Los Alamos National Security, Llc Miniturized lateral flow device for rapid and sensitive detection of proteins or nucleic acids
US20080047835A1 (en) * 2006-08-22 2008-02-28 Macconnell William P Genomic DNA Purifier
US11560588B2 (en) 2006-08-24 2023-01-24 California Institute Of Technology Multiplex Q-PCR arrays
BRPI0714538A2 (pt) * 2006-08-24 2013-11-26 Du Pont Sequências de primers de diagnóstico de ihhnv isolada, par de diferentes sequências de primers de diagnóstico de ihhnv, kit de detecção de ihhnv, métodos de detecção da presença de ihhnv em amostras e método de determinação da qualidade de ihhnv em uma amostra
CN101522919B (zh) 2006-08-24 2013-08-07 纳幕尔杜邦公司 用于诊断虾病原体的序列
WO2008024292A1 (en) 2006-08-24 2008-02-28 E. I. Du Pont De Nemours And Company Sequences diagnostic for shrimp pathogens
WO2008026198A2 (en) 2006-08-28 2008-03-06 Yeda Research And Development Co. Ltd. Methods of generating glial and neuronal cells and use of same for the treatment of medical conditions of the cns
CA2696603A1 (en) 2006-08-31 2008-07-31 Baylor Research Institute Jc virus vaccine
US20100137440A1 (en) * 2006-09-11 2010-06-03 Yale University Lysine riboswitches, structure-based compound design with lysine riboswitches, and methods and compositions for use of and with lysine riboswitches
US8097419B2 (en) 2006-09-12 2012-01-17 Longhorn Vaccines & Diagnostics Llc Compositions and method for rapid, real-time detection of influenza A virus (H1N1) swine 2009
US8652782B2 (en) 2006-09-12 2014-02-18 Longhorn Vaccines & Diagnostics, Llc Compositions and methods for detecting, identifying and quantitating mycobacterial-specific nucleic acids
US9481912B2 (en) 2006-09-12 2016-11-01 Longhorn Vaccines And Diagnostics, Llc Compositions and methods for detecting and identifying nucleic acid sequences in biological samples
WO2008033936A2 (en) 2006-09-12 2008-03-20 Sierra Molecular Corporation Removal of molecular assay interferences for nucleic acids employing buffered solutions of chaotropes
US8080645B2 (en) 2007-10-01 2011-12-20 Longhorn Vaccines & Diagnostics Llc Biological specimen collection/transport compositions and methods
EP2064332B1 (en) 2006-09-14 2012-07-18 Ibis Biosciences, Inc. Targeted whole genome amplification method for identification of pathogens
CA2921048C (en) 2006-09-15 2018-06-05 Ottawa Hospital Research Institute Oncolytic rhabdovirus
US8216593B2 (en) * 2006-09-16 2012-07-10 Board Of Regents, The University Of Texas System Parasite vaccine
WO2008036765A2 (en) 2006-09-19 2008-03-27 Asuragen, Inc. Micrornas differentially expressed in pancreatic diseases and uses thereof
WO2008048410A2 (en) * 2006-09-19 2008-04-24 Human Biomolecular Research Institute Diagnostic methods and genetic markers for alzheimer disease
EP2617814B1 (en) 2006-09-21 2015-11-18 BASF Enzymes LLC Phytases, nucleic acids encoding them and methods for making and using them
JP2010504360A (ja) * 2006-09-22 2010-02-12 ベイラー リサーチ インスティテュート インスリン産生細胞への膵腺房細胞のインビボでの形質転換
WO2008094316A2 (en) * 2006-09-22 2008-08-07 Stowers Institute Of Medical Research Novel branchiostoma derived fluorescent proteins
EP2069502B1 (en) 2006-09-27 2014-02-26 Novo Nordisk A/S Method for making maturated insulin polypeptides
WO2008038287A2 (en) 2006-09-28 2008-04-03 Hepacore Ltd. N-terminal fgf variants having increased receptor selectivity and uses thereof
FR2906537A1 (fr) 2006-09-28 2008-04-04 Biomerieux Sa Procede de diagnostic in vitro du cancer broncho-pulmonaire par detection des transcrits majoritaires alternatifs du gene klk8 codant la kallicreine 8 et son utilisation pour le pronostic de survie
EP2067041A2 (en) 2006-10-03 2009-06-10 Biogen Idec MA, Inc. Biomarkers and assays for the treatment of cancer
WO2008041183A2 (en) 2006-10-05 2008-04-10 Technion Research & Development Foundation Ltd. Microtubes and methods of producing same
US7888059B2 (en) * 2006-10-05 2011-02-15 Yeda Research And Development Co. Ltd. Highly purified and stabilized Na,K-ATPase isoforms and methods of producing same
ZA200901742B (en) * 2006-10-06 2010-06-30 Johnson & Johnson Res Pty Ltd Moleculor switches and methods for their use
US7754429B2 (en) 2006-10-06 2010-07-13 Illumina Cambridge Limited Method for pair-wise sequencing a plurity of target polynucleotides
EP1914303A1 (en) * 2006-10-09 2008-04-23 Qiagen GmbH Thermus eggertssonii DNA polymerases
US9163229B2 (en) 2006-10-10 2015-10-20 Trovagene, Inc. Compositions, methods and kits for isolating nucleic acids from body fluids using anion exchange media
US20080149655A1 (en) * 2006-10-11 2008-06-26 Imi Cornelius Inc. Variable capacity refrigeration system
GB0620259D0 (en) 2006-10-12 2006-11-22 Astex Therapeutics Ltd Pharmaceutical compounds
WO2008044045A1 (en) 2006-10-12 2008-04-17 Astex Therapeutics Limited Pharmaceutical combinations
WO2008043847A1 (en) 2006-10-13 2008-04-17 Novo Nordisk Health Care Ag Processing enzymes fused to basic protein tags
US20080206758A1 (en) * 2006-10-17 2008-08-28 Lcm Technologies, Inc. Polynucleic acid-attached particles and their use in genomic analysis
US9845494B2 (en) 2006-10-18 2017-12-19 Affymetrix, Inc. Enzymatic methods for genotyping on arrays
US7777877B2 (en) * 2006-10-20 2010-08-17 California Institute Of Technology High efficiency coupling optics for pumping and detection of fluorescence
WO2008130437A2 (en) * 2006-10-20 2008-10-30 Arizona Board Of Regents For And On Behalf Of Arizona State University Modified cyanobacteria
EP2431483B1 (en) 2006-10-20 2015-04-01 Celera Corporation Genetic polymorphisms associated with venous thrombosis, methods of detection and uses thereof
US7709203B2 (en) 2006-10-20 2010-05-04 E.I. Du Pont De Nemours And Company Sequences diagnostic for shrimp pathogens
PL2390339T3 (pl) 2006-10-23 2013-12-31 Du Pont Delta-8 desaturazy i ich zastosowanie w wytwarzaniu polinienasyconych kwasów tłuszczowych
JP2010507387A (ja) 2006-10-25 2010-03-11 クアーク・ファーマスーティカルス、インコーポレイテッド 新規のｓｉＲＮＡおよびその使用方法
US20080124768A1 (en) * 2006-10-31 2008-05-29 Sigma Aldrich Co. Methods and Compositions for Amplification of DNA
EP2078089B1 (en) 2006-10-31 2016-05-04 E. I. du Pont de Nemours and Company Soybean event dp-305423-1 and compositions and methods for the identification and/or detection thereof
EP2088926A4 (en) * 2006-11-02 2011-07-13 Immunivest Corp IMAGING AN ACTIVATED VASCULAR ENDOTHELIUM BY IMMUNOMAGNETIC MRI CONTRASTANT
WO2008066655A2 (en) 2006-11-02 2008-06-05 Yale University Assessment of oocyte competence
KR100803055B1 (ko) * 2006-11-03 2008-02-18 한국과학기술원 구면베어링 조립체의 제조장치 및 그 제조방법
US20100076691A1 (en) 2006-11-03 2010-03-25 Baylor Research Institute Diagnosis of Metastatic Melanoma and Monitoring Indicators of Immunosuppression Through Blood Leukocyte Microarray Analysis
US9375440B2 (en) * 2006-11-03 2016-06-28 Medtronic, Inc. Compositions and methods for making therapies delivered by viral vectors reversible for safety and allele-specificity
US8324367B2 (en) 2006-11-03 2012-12-04 Medtronic, Inc. Compositions and methods for making therapies delivered by viral vectors reversible for safety and allele-specificity
WO2008061165A2 (en) 2006-11-14 2008-05-22 Handylab, Inc. Microfluidic cartridge and method of making same
US7492312B2 (en) * 2006-11-14 2009-02-17 Fam Adly T Multiplicative mismatched filters for optimum range sidelobe suppression in barker code reception
AU2007321678B2 (en) 2006-11-15 2014-03-20 The University Of British Columbia Polymorphisms predictive of anthracycline-induced cardiotoxicity
US7988668B2 (en) * 2006-11-21 2011-08-02 Medtronic, Inc. Microsyringe for pre-packaged delivery of pharmaceuticals
US7819842B2 (en) * 2006-11-21 2010-10-26 Medtronic, Inc. Chronically implantable guide tube for repeated intermittent delivery of materials or fluids to targeted tissue sites
US20080131880A1 (en) * 2006-11-22 2008-06-05 Bortolin Laura T PNA-DNA oligomers and methods of use thereof
CA2670967C (en) 2006-11-29 2016-05-10 University Of Iowa Research Foundation Alternative export pathways for vector expressed rna interference
US8455626B2 (en) 2006-11-30 2013-06-04 Abbott Laboratories Aβ conformer selective anti-aβ globulomer monoclonal antibodies
US8133701B2 (en) * 2006-12-05 2012-03-13 Sequenom, Inc. Detection and quantification of biomolecules using mass spectrometry
US7902345B2 (en) 2006-12-05 2011-03-08 Sequenom, Inc. Detection and quantification of biomolecules using mass spectrometry
ES2553331T3 (es) 2006-12-07 2015-12-07 Dow Agrosciences Llc Nuevos genes marcadores seleccionables
EP2104734A2 (en) * 2006-12-08 2009-09-30 Asuragen, INC. Mir-20 regulated genes and pathways as targets for therapeutic intervention
CN101675165A (zh) 2006-12-08 2010-03-17 奥斯瑞根公司 Let-7微小rna的功能和靶标
KR20090098880A (ko) 2006-12-12 2009-09-17 바이오렉시스 파마슈티칼 코포레이션 트랜스페린 융합 단백질 라이브러리
UA108733C2 (uk) 2006-12-12 2015-06-10 Толерантна до гербіциду рослина соняшника
CN102851369B (zh) 2006-12-13 2015-01-21 卢米耐克斯公司 用于实时pcr多重分析的系统和方法
US7972828B2 (en) * 2006-12-19 2011-07-05 Sigma-Aldrich Co. Stabilized compositions of thermostable DNA polymerase and anionic or zwitterionic detergent
JP2010514692A (ja) 2006-12-20 2010-05-06 バイエル ヘルスケア リミティド ライアビリティ カンパニー 癌の治療に有用なヒドロキシメチルフェニルピラゾリル尿素化合物
BRPI0719602B1 (pt) * 2006-12-20 2021-05-18 Evogene Ltd construção de ácido nucléicos, e, métodos para aumentar biomassa de uma planta, para aumentar o vigor de uma planta, para aumentar o rendimento de uma planta, para aumentar a tolerância de uma planta ao stress abiótico, para aprimorar a qualidade de fibra e/ou rendimento de uma planta que produz fibra e para produzir fibras de algodão
EP2479266B1 (en) 2006-12-21 2016-03-09 BASF Enzymes LLC Amylases and glucoamylases, nucleic acids encoding them and methods for making and using them
JP5340167B2 (ja) 2006-12-21 2013-11-13 ジェン−プロウブ インコーポレイテッド 核酸増幅のための方法および組成物
EP2121687B1 (en) 2006-12-22 2015-10-14 Astex Therapeutics Limited Tricyclic amine derivatives as protein tyrosine kinase inhibitors
US7794937B2 (en) * 2006-12-22 2010-09-14 Quest Diagnostics Investments Incorporated Cystic fibrosis transmembrane conductance regulator gene mutations
JP5442448B2 (ja) 2006-12-22 2014-03-12 アステックス、セラピューティックス、リミテッド Ｆｇｆｒインヒビターとしての二環式ヘテロ環式化合物
EP1939303A1 (en) * 2006-12-27 2008-07-02 Wageningen Universiteit Method for detecting cyst nematodes
EP2069525A1 (en) * 2006-12-29 2009-06-17 Applied Biosystems, LLC Systems and methods for detecting nucleic acids
EP2118310B1 (en) * 2006-12-29 2013-03-06 Applied Biosystems, LLC Systems and methods for detecting nucleic acids
US8535888B2 (en) * 2006-12-29 2013-09-17 Mayo Foundation For Medical Education And Research Compositions and methods for detecting methicillin-resistant S. aureus
US20080167198A1 (en) * 2007-01-04 2008-07-10 Christopher Gerard Cooney Filter based detection system
US7820389B2 (en) * 2007-01-10 2010-10-26 Geneohm Sciences, Inc. Inhibition of mismatch hybridization by a universal competitor DNA
JP5690068B2 (ja) 2007-01-11 2015-03-25 エラスムス ユニバーシティ メディカル センター 環状染色体コンホメーション捕捉（４ｃ）
US20100004134A1 (en) * 2007-01-12 2010-01-07 Lawrence Horowitz Combinatorial libraries of conformationally constrained polypeptide sequences
US20080171906A1 (en) * 2007-01-16 2008-07-17 Everaerts Frank J L Tissue performance via hydrolysis and cross-linking
CA2675967A1 (en) * 2007-01-16 2008-07-24 Yissum Research Development Company Of The Hebrew University Of Jerusale M Nucleic acid constructs and methods for specific silencing of h19
US8247195B2 (en) 2007-01-16 2012-08-21 The University Of Washington Methods and host cells for recombinant protein expression
AU2008205457A1 (en) * 2007-01-18 2008-07-24 University Of Southern California Gene polymorphisms predictive for dual TKI therapy
EP2132341A2 (en) 2007-01-18 2009-12-16 University Of Southern California Polymorphisms in the egfr pathway as markers for cancer treatment
CN101711257A (zh) 2007-01-22 2010-05-19 瓦弗根公司 用于高通量化学反应的装置
US20100196403A1 (en) * 2007-01-29 2010-08-05 Jacob Hochman Antibody conjugates for circumventing multi-drug resistance
NZ598285A (en) 2007-01-30 2013-10-25 Syngenta Participations Ag Enzymes for the treatment of lignocellulosics, nucleic acids encoding them and methods for making and using them
EP2129789B1 (en) 2007-01-31 2013-03-06 Celera Corporation Method of determining risk associated with breast cancer metastasis by the determination of a molecular prognostic signature.
PT2118123E (pt) 2007-01-31 2016-02-10 Harvard College Péptidos de p53 estabilizados e suas utilizações
EP2117616A2 (en) 2007-01-31 2009-11-18 Technion Research & Development Foundation Ltd. Electrospun scaffolds and methods of generating and using same
US8293489B2 (en) * 2007-01-31 2012-10-23 Henkin Robert I Methods for detection of biological substances
CA2676932C (en) 2007-02-01 2015-11-24 Technion Research & Development Foundation Ltd. Albumin fibers and fabrics and methods of generating and using same
NZ589179A (en) 2007-02-02 2011-01-28 Genera Biosystems Ltd Generation of nucleic acid molecules using solid phase amplification
EP2121983A2 (en) 2007-02-02 2009-11-25 Illumina Cambridge Limited Methods for indexing samples and sequencing multiple nucleotide templates
US8772046B2 (en) 2007-02-06 2014-07-08 Brandeis University Manipulation of fluids and reactions in microfluidic systems
EP1956097A1 (en) * 2007-02-06 2008-08-13 bioMerieux B.V. Method for discriminating single nucleotide polymorphisms (SNPs)
US8143046B2 (en) * 2007-02-07 2012-03-27 Danisco Us Inc., Genencor Division Variant Buttiauxella sp. phytases having altered properties
US20080220498A1 (en) 2007-03-06 2008-09-11 Cervin Marguerite A Variant Buttiauxella sp. phytases having altered properties
EP2114983B8 (en) * 2007-02-07 2015-02-18 The Regents of the University of Colorado, A Body Corporate Axl tyrosine kinase inhibitors and methods of making and using the same
AU2008213634B2 (en) * 2007-02-08 2013-09-05 Sequenom, Inc. Nucleic acid-based tests for RhD typing, gender determination and nucleic acid quantification
US20110020797A1 (en) * 2007-02-09 2011-01-27 Bristol-Myers Squibb Company Methods For Identifying Patients With An Increased Likelihood Of Responding To DPP-IV Inhibitors
CA2678261A1 (en) 2007-02-09 2008-08-14 The Regents Of The University Of California Biofuel production by recombinant microorganisms
US20090258360A1 (en) * 2007-02-14 2009-10-15 Valberg Stephanie J Method of detecting equine polysaccharide storage myopathy
US8268557B2 (en) 2007-02-14 2012-09-18 Valberg Stephanie J Method of detecting equine polysaccharide storage myopathy
CA2678451A1 (en) 2007-02-20 2008-08-28 Robert A. Horlick Somatic hypermutation systems
WO2008103770A2 (en) 2007-02-20 2008-08-28 Applera Corporation Multiplex compositions and methods for quantification of human nuclear dna and human male dna and detection of pcr inhibitors
NL1033431C2 (nl) 2007-02-20 2008-08-21 Expressive Res Bv Bepaling van kwaliteitskenmerken bij land- of tuinbouwproducten.
MX2009008878A (es) * 2007-02-21 2009-08-28 Decode Genetics Ehf Variantes de susceptibilidad genetica asociada con la enfermedad cardiovascular.
EP1962084A1 (en) 2007-02-21 2008-08-27 Roche Diagnostics GmbH Apparatus for emitting and detecting beams of light
WO2008104002A2 (en) 2007-02-23 2008-08-28 Ibis Biosciences, Inc. Methods for rapid forensic dna analysis
EP1961825A1 (en) 2007-02-26 2008-08-27 INSERM (Institut National de la Santé et de la Recherche Medicale) Method for predicting the occurrence of metastasis in breast cancer patients
WO2008106115A2 (en) 2007-02-26 2008-09-04 Monogram Biosciences, Inc. Compositions and methods for determining whether a subject would benefit from co-receptor inhibitor therapy
US20100311767A1 (en) 2007-02-27 2010-12-09 Abbott Gmbh & Co. Kg Method for the treatment of amyloidoses
ES2662036T3 (es) 2007-02-28 2018-04-05 Yeda Research And Development Company Limited Secuencias que se dirigen al núcleo
CA2677771A1 (en) 2007-03-01 2008-09-04 Symphogen A/S Method for cloning cognate antibodies
US20100086990A1 (en) * 2007-03-02 2010-04-08 Corbett Research Pty Ltd Apparatus and method for nucleic acid amplification
EP2079839A4 (en) 2007-03-05 2009-11-18 Cancer Care Ontario ASSESSMENT OF COLORECTAL CARCINOMA RISK
US8435551B2 (en) 2007-03-06 2013-05-07 Musculoskeletal Transplant Foundation Cancellous construct with support ring for repair of osteochondral defects
AU2008225859B2 (en) 2007-03-09 2014-06-26 Novozymes A/S Thermostable asparaginases
BRPI0808513A2 (pt) 2007-03-09 2014-08-19 Danisco Us Inc Genencor Div Variantes de alfa-amilase de espécies de bacillus alcalifílico, composições compreendendo variantes de alfa-amilase e métodos de uso
GB0704932D0 (en) 2007-03-14 2007-04-25 Astex Therapeutics Ltd Pharmaceutical compounds
KR20080084528A (ko) 2007-03-15 2008-09-19 제네렉스 바이오테라퓨틱스 인크. 종양살상형 백시니아 바이러스 암 치료
EP2121984A2 (en) * 2007-03-16 2009-11-25 454 Life Sciences Corporation System and method for detection of hiv drug resistant variants
WO2008116032A1 (en) 2007-03-21 2008-09-25 Effat Emamian Compositions and methods for inhibiting tumor cell growth
WO2008116184A1 (en) 2007-03-21 2008-09-25 Applera Corporation Adaptive thermal block temperature control method and system
WO2008116186A1 (en) 2007-03-22 2008-09-25 Keck Graduate Institute Systems and devices for isothermal biochemical reactions and/or analysis
EP2140031A4 (en) 2007-03-26 2011-04-20 Sequenom Inc RESTRICTION ENDONUCLEASE REINFORCED POLYMORPHIC SEQUENCE DETECTION
WO2008118324A2 (en) 2007-03-26 2008-10-02 Macrogenics, Inc. Composition and method of treating cancer with an anti-uroplakin ib antibody
KR101540822B1 (ko) 2007-03-27 2015-07-30 씨 레인 바이오테크놀로지스, 엘엘씨 항체 대용물 경쇄 서열을 포함하는 구축물 및 라이브러리
US7892739B2 (en) * 2007-03-27 2011-02-22 Lehigh University Systems, compositions and methods for nucleic acid detection
EP2508531B1 (en) 2007-03-28 2016-10-19 President and Fellows of Harvard College Stitched polypeptides
EP2134870B1 (en) * 2007-03-28 2014-02-26 Monsanto Technology, LLC Utility of snp markers associated with major soybean plant maturity and growth habit genomic regions
CA2682093A1 (en) 2007-03-29 2008-10-09 Technion Research & Development Foundation Ltd. Antibodies, methods and kits for diagnosing and treating melanoma
WO2008121802A2 (en) * 2007-03-30 2008-10-09 Cedars-Sinai Medical Center Lipoprotein lipase and its effect on statin treatments
EP1978111B1 (en) 2007-04-02 2013-03-27 Gen-Probe Incorporated Compositions, kits and related methods for the detection and/or monitoring of Pseudomonas aeruginosa
US10017827B2 (en) 2007-04-04 2018-07-10 Nidera S.A. Herbicide-resistant sunflower plants with multiple herbicide resistant alleles of AHASL1 and methods of use
EP2142673B1 (en) * 2007-04-05 2013-05-22 Johnson & Johnson Research Pty Limited Nucleic acid enzymes and complexes and methods for their use
EP2145949A4 (en) 2007-04-06 2013-07-03 Universal Bio Research Co Ltd DEVICE AND METHOD FOR CONTROLLING TEMPERATURE
CN101854798B (zh) 2007-04-09 2013-04-03 伊沃基因有限公司 用于增加植物的油含量、生长速率和/或产量的多核苷酸、多肽和方法
ES2599632T3 (es) 2007-04-09 2017-02-02 University Of Florida Research Foundation, Inc. Composiciones de vectores rAAV que tienen proteínas de la cápside modificadas en tirosina y métodos para su uso
US7794701B2 (en) 2007-04-16 2010-09-14 E.I. Du Pont De Nemours And Company Δ-9 elongases and their use in making polyunsaturated fatty acids
US7910342B2 (en) 2007-04-18 2011-03-22 Butamax(Tm) Advanced Biofuels Llc Fermentive production of isobutanol using highly active ketol-acid reductoisomerase enzymes
US8592221B2 (en) 2007-04-19 2013-11-26 Brandeis University Manipulation of fluids, fluid components and reactions in microfluidic systems
CA2684570A1 (en) 2007-04-19 2008-10-30 Molecular Detection Inc. Methods, compositions and kits for detection and analysis of antibiotic-resistant bacteria
WO2008131348A2 (en) * 2007-04-20 2008-10-30 Immunotrex Corporation Compositions and methods for treatment of uncontrolled cell growth
PL2144633T3 (pl) * 2007-04-23 2015-02-27 Sabag Rfa Ltd Układ do transportu czynników terapeutycznych do żywych komórek i jąder komórkowych
US9156865B2 (en) 2007-04-23 2015-10-13 Deliversir Ltd System for delivering therapeutic agents into living cells and cells nuclei
US9556210B2 (en) 2007-04-23 2017-01-31 Sabag-Rfa Ltd. System for delivering therapeutic agents into living cells and cells nuclei
ES2564312T3 (es) 2007-05-01 2016-03-21 Tel Hashomer Medical Research Infrastructure And Services Ltd. Métodos y kits para detectar células fetales en la sangre materna
US20080274458A1 (en) * 2007-05-01 2008-11-06 Latham Gary J Nucleic acid quantitation methods
WO2008137586A1 (en) * 2007-05-01 2008-11-13 University Of Miami Transcriptomic biomarkers for individual risk assessment in new onset heart failure
CA2685675C (en) 2007-05-01 2016-02-16 Research Development Foundation Immunoglobulin fc libraries
KR20100058420A (ko) 2007-05-01 2010-06-03 유니버시티 오브 마이애미 심근염 전사체 바이오마커
US20090124508A1 (en) * 2007-05-02 2009-05-14 Anthony Peter Caruso Computational diagnostic methods for identifying organisms and applications thereof
CA2587198A1 (en) * 2007-05-02 2008-11-02 Spartan Bioscience Inc. Method for increasing the speed of nucleic acid amplification reactions
US7943365B2 (en) 2007-05-03 2011-05-17 E.I. Du Pont De Nemours And Company Δ-5 desaturases and their use in making polyunsaturated fatty acids
DK3360571T3 (da) 2007-05-03 2021-01-04 Agency For Science Tech And Research Astarstar Antistoffer, der binder til et intracellulært PRL-1- eller PRL-3-polypeptid
ATE524566T1 (de) * 2007-05-04 2011-09-15 Myconostica Ltd Nachweis von triazolresistenz bei aspergillus
SG187447A1 (en) 2007-05-07 2013-02-28 Protalix Ltd Large scale disposable bioreactor
EP2158333A4 (en) * 2007-05-14 2010-12-29 Synvista Therapeutics Inc USE OF HAPTOGLOBIN ENTYPIZATION FOR DIAGNOSIS AND TREATMENT OF INCORRECT REVERSE CHOLESTER INTRANSPORT
WO2008141514A1 (en) * 2007-05-17 2008-11-27 Wondergen Bio-Medicine Technology Co., Ltd. System substitute pcr
EP2147104B1 (en) * 2007-05-21 2015-09-09 Danisco US Inc. Use of an aspartic protease (nsp24) signal sequence for heterologous protein expression
EP2164994A4 (en) * 2007-05-29 2010-07-21 Univ Yale Inc METHODS AND COMPOSITIONS RELATED TO RIBOINTERRUPTERS THAT REGULATE ALTERNATIVE SPLICE AND RNA PROCESSING
AU2008255641B2 (en) 2007-05-31 2014-03-13 Board Of Regents Of The University Of Texas System Diagnostic markers for ankylosing spondylitis and uses thereof
AU2008260029B2 (en) 2007-05-31 2015-02-12 Yale University A genetic lesion associated with cancer
EP2615175B1 (en) 2007-05-31 2018-08-08 Genmab A/S Monovalent human antibodies
BRPI0811967B1 (pt) 2007-06-01 2023-01-17 Terravia Holdings, Inc Microalga chlorella ou prototheca e método para produção de lipídios microbianos
US9598724B2 (en) 2007-06-01 2017-03-21 Ibis Biosciences, Inc. Methods and compositions for multiple displacement amplification of nucleic acids
PT2152663E (pt) 2007-06-04 2014-06-03 Univ Ben Gurion Compostos de triarilo e composições que compreendem os mesmos
FR2917090B1 (fr) * 2007-06-11 2012-06-15 Biomerieux Sa Reactifs de marquage portant des fonctions diazo et nitro, procedes de synthese de tels reactifs et procedes de detection de molecules biologiques
CA2689557C (en) 2007-06-15 2018-08-14 National Research Council Of Canada Engineered versions of polysialyltransferases with enhanced enzymatic properties
CN101715487A (zh) 2007-06-18 2010-05-26 米迪缪尼有限公司 血凝素多肽中有变化的b型流感病毒
JP2010530975A (ja) 2007-06-21 2010-09-16 モメンタ ファーマシューティカルズ インコーポレイテッド コポリマーアッセイ
US20090324596A1 (en) * 2008-06-30 2009-12-31 The Trustees Of Princeton University Methods of identifying and treating poor-prognosis cancers
WO2009031054A2 (en) 2007-06-29 2009-03-12 Population Genetics Technologies Ltd. Methods and compositions for isolating nucleic acid sequence variants
EP2170384B1 (en) 2007-07-02 2016-04-13 Etubics Corporation Methods and compositions for producing an adenovirus vector for use with multiple vaccinations
US20090054984A1 (en) 2007-08-20 2009-02-26 Histogenics Corporation Method For Use Of A Double-Structured Tissue Implant For Treatment Of Tissue Defects
CA2692793C (en) 2007-07-06 2014-05-20 The Regents Of The University Of Michigan Mipol1-etv1 gene rearrangements
EP2167689B1 (en) 2007-07-06 2012-10-31 The Regents Of The University Of Michigan Recurrent gene fusions in prostate cancer
WO2009009493A2 (en) * 2007-07-09 2009-01-15 THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTEMENT OF HEALTH AND HUMAN SERVICES Aegyptin and uses thereof
WO2009009759A2 (en) 2007-07-11 2009-01-15 Fraunhofer Usa, Inc. Yersinia pestis antigens, vaccine compositions, and related methods
ES2591281T3 (es) 2007-07-12 2016-11-25 Gitr, Inc. Terapias de combinación que emplean moléculas de enlazamiento a GITR
WO2009012185A1 (en) 2007-07-13 2009-01-22 Handylab, Inc. Polynucleotide capture materials, and methods of using same
USD621060S1 (en) 2008-07-14 2010-08-03 Handylab, Inc. Microfluidic cartridge
US9186677B2 (en) 2007-07-13 2015-11-17 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US8287820B2 (en) 2007-07-13 2012-10-16 Handylab, Inc. Automated pipetting apparatus having a combined liquid pump and pipette head system
US8105783B2 (en) 2007-07-13 2012-01-31 Handylab, Inc. Microfluidic cartridge
US9618139B2 (en) 2007-07-13 2017-04-11 Handylab, Inc. Integrated heater and magnetic separator
US8182763B2 (en) 2007-07-13 2012-05-22 Handylab, Inc. Rack for sample tubes and reagent holders
US8133671B2 (en) 2007-07-13 2012-03-13 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US20090136385A1 (en) 2007-07-13 2009-05-28 Handylab, Inc. Reagent Tube
CA2696833A1 (en) 2007-07-15 2009-01-22 Yitzchak Hillman Disease treatment via antimicrobial peptides or their inhibitors
IL184627A0 (en) 2007-07-15 2008-12-29 Technion Res & Dev Foundation Agents for diagnosing and modulating metastasis and fibrosis as well as inflammation in a mammalian tissue
US20090023138A1 (en) * 2007-07-17 2009-01-22 Zila Biotechnology, Inc. Oral cancer markers and their detection
EP2182943B1 (en) 2007-07-23 2016-10-26 Janssen Biotech, Inc. Methods and compositions for treating fibrosis related disorders using il-17 antagonists
WO2009013750A2 (en) 2007-07-24 2009-01-29 Evogene Ltd. Polynucleotides, polypeptides encoded thereby, and methods of using same for increasing abiotic stress tolerance and/or biomass and/or yield in plants expressing same
AU2008279868B2 (en) 2007-07-26 2014-03-20 Monsanto Holland B.V. Novel polygalacturonases and their uses
US8221981B2 (en) * 2007-07-30 2012-07-17 Argos Therapeutics, Inc. Primers and probes for the amplification and detection of HIV Gag, Rev and Nef polynucleotides
CA2693102C (en) * 2007-07-31 2020-03-10 Verenium Corporation Tailored multi-site combinatorial assembly
CA2694718A1 (en) * 2007-07-31 2009-02-05 University Of Saskatchewan Genetic variation in pro-melanin-concentrating hormone gene affects carcass traits in cattle
JP5852781B2 (ja) * 2007-07-31 2016-02-03 マイクロニクス， インコーポレイテッド 衛生的スワブ採取システム、マイクロ流体アッセイデバイスおよび診断アッセイのための方法
US8455190B2 (en) * 2007-08-01 2013-06-04 Dana-Farber Cancer Institute, Inc. Enrichment of a target sequence
WO2009017833A2 (en) 2007-08-02 2009-02-05 Arresto Biosciences Methods and compositions for treatment and diagnosis of fibrosis, tumor invasion, angiogenesis, and metastasis
WO2009042291A2 (en) * 2007-08-03 2009-04-02 Igor Kutyavin Accelerated cascade amplification (aca) of nucleic acids comprising strand and sequence specific dna nicking
CA2694832A1 (en) 2007-08-06 2009-02-12 Orion Genomics Llc Novel single nucleotide polymorphisms and combinations of novel and known polymorphisms for determining the allele-specific expression of the igf2 gene
CN101361968B (zh) 2007-08-06 2011-08-03 健能隆医药技术（上海）有限公司 白介素-22在治疗脂肪肝中的应用
MX2010001657A (es) 2007-08-15 2010-03-15 Yeda Res & Dev Reguladores de mmp-9 y usos de los mismos.
US8071561B2 (en) 2007-08-16 2011-12-06 Chrontech Pharma Ab Immunogen platform
US20110123481A1 (en) 2007-08-16 2011-05-26 Remedor Biomed Ltd. Erythropoietin and fibronectin compositions for therapeutic and cosmetic applications
US7897139B2 (en) * 2007-08-17 2011-03-01 Biochrom Pharma, Inc. PTHrP, its isoforms and antagonist thereto in the diagnosis and treatment of disease
US8501929B2 (en) 2007-08-17 2013-08-06 Biochrom Pharma Inc. PTHrP, its isoforms and antagonist thereto in the diagnosis and treatment of disease
EP2195656A4 (en) 2007-08-21 2011-10-19 Senomyx Inc HUMAN T2R BITTERITY RECEPTORS AND USES THEREOF
US20090055243A1 (en) 2007-08-21 2009-02-26 Jayson Lee Lusk Systems and methods for predicting a livestock marketing method
WO2009026502A1 (en) * 2007-08-22 2009-02-26 Wyeth Nested pcr-based method for specific genotyping of the fc-gamma receptor iiia gene
US11041215B2 (en) 2007-08-24 2021-06-22 Longhorn Vaccines And Diagnostics, Llc PCR ready compositions and methods for detecting and identifying nucleic acid sequences
US10004799B2 (en) 2007-08-27 2018-06-26 Longhorn Vaccines And Diagnostics, Llc Composite antigenic sequences and vaccines
JP2010537637A (ja) 2007-08-27 2010-12-09 アプライド バイオシステムズ インコーポレイテッド Ｐｃｒのための方法および組成物
CA2697373C (en) 2007-08-27 2019-05-21 Longhorn Vaccines & Diagnostics, Llc Immunogenic compositions and methods
CN101801514A (zh) 2007-08-28 2010-08-11 考贝特研究控股公司 带有可选择性的打开的试样端口的热循环装置
AR071243A1 (es) 2007-08-29 2010-06-09 Monsanto Technology Llc Metodos y composiciones para usar plantas haploides en el mapeo genetico de caracteristicas, como resistencia a enfermedades
JP2009055815A (ja) * 2007-08-30 2009-03-19 Olympus Corp プライマーキット
CN101868476B (zh) 2007-09-05 2015-02-25 诺沃-诺迪斯克有限公司 胰高血糖素样肽-1衍生物及其制药用途
US9388457B2 (en) * 2007-09-14 2016-07-12 Affymetrix, Inc. Locus specific amplification using array probes
EP2195005B1 (en) 2007-09-14 2015-05-27 University of South Florida Gene signature for the prediction of radiation therapy response
US8361714B2 (en) 2007-09-14 2013-01-29 Asuragen, Inc. Micrornas differentially expressed in cervical cancer and uses thereof
CN102308206A (zh) * 2007-09-17 2012-01-04 红象牙有限责任公司 自作用信号产生检测设备和方法
EP2201134B1 (en) 2007-09-19 2018-11-21 The Research Foundation of State University of New York Gene expression signatures in enriched tumor cell samples
CN107050057B (zh) 2007-09-19 2021-04-20 普拉里斯坦有限公司 来自脂肪或胎盘组织的粘附细胞及其在治疗中的用途
WO2009039466A1 (en) 2007-09-20 2009-03-26 Vanderbilt University Free solution measurement of molecular interactions by backscattering interferometry
US7695963B2 (en) * 2007-09-24 2010-04-13 Cythera, Inc. Methods for increasing definitive endoderm production
NZ583944A (en) 2007-09-28 2012-06-29 Portola Pharm Inc Antidotes for factor xa inhibitors and methods of using the same
WO2009085355A2 (en) 2007-10-01 2009-07-09 Longhorn Vaccines & Diagnostics Llc Biological specimen collection and transport system and methods of use
US11041216B2 (en) 2007-10-01 2021-06-22 Longhorn Vaccines And Diagnostics, Llc Compositions and methods for detecting and quantifying nucleic acid sequences in blood samples
EP2205744B1 (en) 2007-10-03 2015-01-14 BP Corporation North America Inc. Xylanases, nucleic acids encoding them and methods for making and using them
KR101110013B1 (ko) * 2007-10-05 2012-02-29 (주)바이오니아 서열 내에 어베이직 부분을 포함하는 ｐｃｒ 증폭용프라이머
US9273310B2 (en) 2007-10-08 2016-03-01 Synthetic Genomics, Inc. Methods for cloning and manipulating genomes
GB0720041D0 (en) 2007-10-12 2007-11-21 Astex Therapeutics Ltd New Compounds
CN101903104B (zh) 2007-10-12 2014-06-25 瑞昂尼克公司 综合微流体装置及其方法
GB0720038D0 (en) 2007-10-12 2007-11-21 Astex Therapeutics Ltd New compounds
US8450106B2 (en) * 2007-10-17 2013-05-28 The Ohio State University Research Foundation Oncolytic virus
WO2009052386A1 (en) * 2007-10-18 2009-04-23 Asuragen, Inc. Micrornas differentially expressed in lung diseases and uses thereof
ES2505440T3 (es) 2007-10-19 2014-10-09 Rappaport Family Institute For Research In The Medical Sciences Composiciones que comprenden semaforinas para el tratamiento de las enfermedades relacionadas con la angiogénesis y los procedimientos de selección de las mismas
CN101903035A (zh) * 2007-10-23 2010-12-01 阿勒根公司 使用经修饰的梭菌毒素治疗慢性神经源性炎症的方法
US20090112482A1 (en) * 2007-10-26 2009-04-30 Sandstrom Perry L Microarray detector and synthesizer
CA2739011A1 (en) * 2007-10-29 2009-05-07 The Regents Of The University Of California Osteoarthritis gene therapy
CA2704048A1 (en) 2007-10-29 2009-05-07 Eisai R & D Management Co., Ltd. Methods for prognosing the ability of a zearalenone analog compound to treat cancer
WO2009059022A1 (en) 2007-10-30 2009-05-07 Complete Genomics, Inc. Apparatus for high throughput sequencing of nucleic acids
TW200930818A (en) 2007-10-30 2009-07-16 Applied Biosystems Method and kits for multiplex amplification of short tandem repeat loci
WO2009059170A2 (en) 2007-10-31 2009-05-07 Idexx Laboratories, Inc. Ehrlichia canis diva (differentiate infection from vaccinated animals)
WO2009058564A2 (en) 2007-11-01 2009-05-07 Maxygen, Inc. Immunosuppressive polypeptides and nucleic acids
CN101868538B (zh) 2007-11-01 2013-07-10 丹尼斯科美国公司 嗜热菌蛋白酶及其变体的生产和在液体洗涤剂中的用途
WO2009059319A1 (en) 2007-11-01 2009-05-07 University Of Iowa Research Foundation Assessing susceptibility to vascular disorders
WO2009059305A2 (en) * 2007-11-01 2009-05-07 The University Of Chicago Red fluorescent proteins with enhanced bacterial expression, increased brightness and reduced aggregation
KR20100088675A (ko) * 2007-11-05 2010-08-10 다니스코 유에스 인크. 변경된 특성을 지닌 바실러스 종 ｔｓ-23 알파-아밀라아제의 변이체
AR069167A1 (es) * 2007-11-05 2010-01-06 Danisco Us Inc Genencor Div Variantes de alfa- amilasa de bacillus licheniformis con termoestabilidad aumentada y/o dependencia de calcio disminuida
US8039212B2 (en) 2007-11-05 2011-10-18 Celera Corporation Genetic polymorphisms associated with liver fibrosis, methods of detection and uses thereof
AR069168A1 (es) * 2007-11-05 2010-01-06 Danisco Us Inc Genencor Div Variantes de alfa -amilasas con propiedades alteradas
US9273100B2 (en) 2007-11-09 2016-03-01 Board Of Trustees Of Michigan State University Use of Galerina marginata genes and proteins for peptide production
US9518097B2 (en) * 2007-11-09 2016-12-13 Board Of Trustees Of Michigan State University Identification and use of genes encoding amatoxin and phallotoxin
KR20100097691A (ko) 2007-11-12 2010-09-03 테라클론 사이언시스, 아이엔씨. 인플루엔자의 치료 및 진단을 위한 조성물 및 방법
US20110033476A1 (en) * 2007-11-12 2011-02-10 Theraclone Sciences Inc. Compositions and methods for the therapy and diagnosis of influenza
WO2010135521A2 (en) 2009-05-20 2010-11-25 Theraclone Sciences, Inc. Compositions and methods for the therapy and diagnosis of influenza
EP2220247A4 (en) 2007-11-16 2011-10-26 Nuvelo Inc ANTIBODIES DIRECTED AGAINST LRP6
EP2728017B1 (en) 2007-11-19 2016-08-24 Celera Corporation Lung cancer markers and uses thereof
WO2009069123A2 (en) 2007-11-26 2009-06-04 Yissum Research Development Company Of The Hebrew University Of Jerusalem Compositions comprising fibrous polypeptides and polysaccharides
WO2015164330A1 (en) 2014-04-21 2015-10-29 Millennium Pharmaceuticals, Inc. Anti-psyk antibody molecules and use of same for syk-targeted therapy
JP5769420B2 (ja) * 2007-11-28 2015-08-26 エンカム ファーマシューティカルズ アクティーゼルスカブ Ｎｃａｍ由来の新規ペプチド（ｆｇｌｓ）
EP2227559B1 (en) 2007-11-30 2018-08-29 QIAGEN Instruments AG Thermal cycling device
US8324369B2 (en) * 2007-11-30 2012-12-04 Baylor College Of Medicine Dendritic cell vaccine compositions and uses of same
WO2009070805A2 (en) 2007-12-01 2009-06-04 Asuragen, Inc. Mir-124 regulated genes and pathways as targets for therapeutic intervention
US9551026B2 (en) 2007-12-03 2017-01-24 Complete Genomincs, Inc. Method for nucleic acid detection using voltage enhancement
EP2067787A1 (en) 2007-12-06 2009-06-10 Boehringer Ingelheim International GmbH Method for controlling insect populations
EP2071034A1 (en) 2007-12-12 2009-06-17 bioMérieux Method for treating a solution in order to destroy any ribonucleic acid after amplification
JP6049982B2 (ja) * 2007-12-13 2016-12-21 ダニスコ・ユーエス・インク イソプレンを産出する組成物及び方法
RU2570559C2 (ru) 2007-12-17 2015-12-10 Пфайзер Лимитед Лечение интерстициального цистита
ES2550757T3 (es) 2007-12-18 2015-11-12 Bioalliance C.V. Anticuerpos que reconocen un epítopo que contiene carbohidratos en CD43 y ACE expresados en células cancerosas y métodos de uso de los mismos
WO2009077766A1 (en) 2007-12-19 2009-06-25 Cancer Research Technology Limited Pyrido[2,3-b]pyrazine-8-substituted compounds and their use
ES2553726T3 (es) 2007-12-20 2015-12-11 Butamax (Tm) Advanced Biofuels Llc Cetol-ácido reductoisomerasa que utiliza NADH
US9228211B2 (en) 2007-12-21 2016-01-05 Dupont Nutrition Biosciences Aps Process of water degumming an edible oil
WO2009085221A2 (en) 2007-12-21 2009-07-09 Biomerieux Sa Detection of methicillin-resistant staphylococcus aureus
CN101952411B (zh) * 2007-12-24 2014-10-29 霍尼韦尔国际公司 用于核酸定量分析的反应器
US9005931B2 (en) * 2007-12-24 2015-04-14 Honeywell International Inc. Programmable oligonucleotide micro array
EP2235214B1 (en) * 2007-12-26 2014-07-09 Gen Probe Inc COMPOSITIONS AND METHODS FOR DETECTING CANDIDA ALBICANS NUCLEIC ACID
WO2009085333A1 (en) 2007-12-27 2009-07-09 Ge Healthcare Bio-Sciences Corp. A single enzyme system for fast, ultra long pcr
EP2238251B1 (en) 2007-12-27 2015-02-11 Protiva Biotherapeutics Inc. Silencing of polo-like kinase expression using interfering rna
DE102007063102B4 (de) * 2007-12-28 2022-02-10 Robert Bosch Gmbh Verfahren zur Erfassung eines periodisch pulsierenden Betriebsparameters
US8367899B2 (en) 2007-12-31 2013-02-05 E I Du Pont De Neumours And Company Gray leaf spot tolerant maize and methods of production
EP2570501A3 (en) 2008-01-02 2013-04-10 Suregene Llc Genetic markers of mental illness
JP5563990B2 (ja) 2008-01-03 2014-07-30 ヴェレニウム コーポレイション トランスフェラーゼおよびオキシドレダクターゼ、それらをコードする核酸並びにそれらを製造および使用する方法
WO2009089466A2 (en) * 2008-01-09 2009-07-16 Keck Graduate Institute System, apparatus and method for material preparation and/or handling
KR101588736B1 (ko) 2008-01-10 2016-01-26 리서치 디벨롭먼트 파운데이션 얼리키아 샤피엔시스에 대한 백신 및 진단제
EP2581453A3 (en) 2008-01-17 2013-07-10 Suregene Llc Genetic Markers of Mental Illness
WO2009092035A2 (en) 2008-01-17 2009-07-23 Sequenom, Inc. Methods and compositions for the analysis of biological molecules
GB0800938D0 (en) * 2008-01-18 2008-02-27 Ge Healthcare Uk Ltd Multiplex cell signalling assay
WO2009092068A1 (en) 2008-01-18 2009-07-23 President And Fellows Of Harvard College Methods of detecting signatures of disease or conditions in bodily fluids
FR2926560A1 (fr) * 2008-01-21 2009-07-24 Millipore Corp Procede d'extraction et de purification d'acides nucleiques sur membrane
US9170060B2 (en) * 2008-01-22 2015-10-27 Lawrence Livermore National Security, Llc Rapid microfluidic thermal cycler for nucleic acid amplification
US20090186344A1 (en) * 2008-01-23 2009-07-23 Caliper Life Sciences, Inc. Devices and methods for detecting and quantitating nucleic acids using size separation of amplicons
MX356866B (es) 2008-01-25 2018-06-18 Multivir Inc Biomarcadores p53.
JP2011511006A (ja) * 2008-01-31 2011-04-07 バンダービルト・ユニバーシティ 肺病態に対する治療
HUE045571T2 (hu) 2008-01-31 2020-01-28 Univ Vanderbilt Koronáriás és artériás aneurizmás szubarachnoideális vérzés kezelésére szolgáló eljárások és készítmények
AU2009208607B2 (en) * 2008-01-31 2013-08-01 Compugen Ltd. Polypeptides and polynucleotides, and uses thereof as a drug target for producing drugs and biologics
CA2713582C (en) * 2008-02-04 2017-02-21 Danisco Us Inc. Ts23 alpha-amylase variants with altered properties
EP2242856A2 (en) * 2008-02-06 2010-10-27 University of Massachusetts Detection of human immunodeficiency virus co-receptor tropism in aviremic subjects
JP5665548B2 (ja) 2008-02-08 2015-02-04 メイヨ・ファウンデーション・フォー・メディカル・エデュケーション・アンド・リサーチ クロストリジウム・ディフィシレの検出
US20090203531A1 (en) 2008-02-12 2009-08-13 Nurith Kurn Method for Archiving and Clonal Expansion
KR101597376B1 (ko) 2008-02-15 2016-02-26 몬산토 테크놀로지 엘엘씨 트랜스제닉 계통 ｍｏｎ８７７６９에 상응하는 대두 식물 및 종자, 및 그의 검출 방법
US20090221620A1 (en) 2008-02-20 2009-09-03 Celera Corporation Gentic polymorphisms associated with stroke, methods of detection and uses thereof
CA2716337C (en) * 2008-02-20 2017-11-14 Streck, Inc. Thermocycler and sample vessel for rapid amplification of dna
BR122018010813B1 (pt) 2008-02-29 2023-12-19 Monsanto Technology Llc Cromossomo, alimento processado ou produto alimentício de milho processado, métodos de detecção da presença de sequências em uma amostra de tecido de milho e para obtenção de uma planta de milho tolerante a déficit de água que carece de um gene marcador selecionável e polinucleotídeo
US20110112186A1 (en) * 2008-02-29 2011-05-12 Isis Innovation Limited Diagnostic methods
WO2009111475A2 (en) 2008-03-03 2009-09-11 Heatflow Technologies, Inc. Heat flow polymerase chain reaction systems and methods
CA2717725A1 (en) 2008-03-05 2009-09-11 Musculoskeletal Transplant Foundation Cancellous constructs, cartilage particles and combinations of cancellous constructs and cartilage particles
US8268981B2 (en) * 2008-03-06 2012-09-18 Abbott Laboratories Plasmodium malariae and plasmodium ovale genes and uses thereof
US8030471B2 (en) 2008-03-06 2011-10-04 Abbott Laboratories Plasmodium malariae and Plasmodium ovale genes and uses thereof
WO2011025477A1 (en) 2009-08-25 2011-03-03 Illumina, Inc. Methods for selecting and amplifying polynucleotides
MX2010009885A (es) * 2008-03-10 2010-11-30 Theraclone Sciences Inc Composiciones y métodos para la terapia y diagnóstico de citomegalovirus.
AU2009224170B2 (en) 2008-03-11 2012-03-29 National Cancer Center Method for measuring chromosome, gene or specific nucleotide sequence copy numbers using SNP array
US9074244B2 (en) * 2008-03-11 2015-07-07 Affymetrix, Inc. Array-based translocation and rearrangement assays
US8709726B2 (en) 2008-03-11 2014-04-29 Sequenom, Inc. Nucleic acid-based tests for prenatal gender determination
GB0804662D0 (en) * 2008-03-13 2008-04-16 Guy S & St Thomas S Nhs Founda Drug response marker
WO2009117327A2 (en) * 2008-03-15 2009-09-24 Hologic, Inc. Compositions and methods for analysis of nucleic acid molecules during amplification reactions
US9695469B2 (en) 2008-03-17 2017-07-04 Stichting Genetwister Ip Expression-linked gene discovery
US8536135B2 (en) * 2008-03-19 2013-09-17 Ontherix, Inc. Adaptive biochemical signatures
US8153370B2 (en) * 2008-03-19 2012-04-10 The Board Of Trustees Of The University Of Illinois RNA from cytology samples to diagnose disease
GB2470672B (en) 2008-03-21 2012-09-12 Nugen Technologies Inc Methods of RNA amplification in the presence of DNA
EP2259787B1 (en) * 2008-03-25 2015-12-23 The Regents of the University of Michigan Ikki inhibitor therapies and screening methods, and related ikki diagnostics
WO2009120808A2 (en) 2008-03-26 2009-10-01 Sequenom, Inc. Restriction endonuclease enhanced polymorphic sequence detection
CA2716585C (en) * 2008-03-27 2017-05-09 E.I. Du Pont De Nemours And Company Zymomonas recombinant for substituted glyceraldehyde-3-phosphate dehydrogenase promoter and xylose isomerase gene for improved xylose utilization
GB0809069D0 (en) 2008-05-19 2008-06-25 Univ Leuven Kath Gene signatures
US20090258928A1 (en) * 2008-04-08 2009-10-15 Asuragen, Inc. Methods and compositions for diagnosing and modulating human papillomavirus (hpv)
US20090253173A1 (en) * 2008-04-08 2009-10-08 Danisco Us Inc., Genencor Division Filamentous fungi with inactivated protease genes for altered protein production
EP2276859B1 (en) 2008-04-08 2011-12-14 Roche Diagnostics GmbH Detection of pcr products in gel electrophoresis
WO2009126789A2 (en) 2008-04-09 2009-10-15 Maxcyte, Inc. Engineering and delivery of therapeutic compositions of freshly isolated cells
CA2693962C (en) * 2008-04-09 2013-08-06 James R. Mickelson Method of detecting canine exercise-induced collapse
EP2108451A1 (de) 2008-04-11 2009-10-14 Eppendorf AG Vorrichtung zum Durchführen von Reaktionen in Proben
GB0806527D0 (en) 2008-04-11 2008-05-14 Astex Therapeutics Ltd Pharmaceutical compounds
CA2721380A1 (en) 2008-04-15 2009-10-22 Protiva Biotherapeutics, Inc. Silencing of csn5 gene expression using interfering rna
NZ588583A (en) 2008-04-15 2012-08-31 Protiva Biotherapeutics Inc Novel lipid formulations for nucleic acid delivery
DK2283124T3 (en) 2008-04-18 2016-09-05 Danisco Us Inc BUTTIAUXELLA SP. PHYTASE VARIANTS
US9249455B2 (en) 2008-04-18 2016-02-02 Luminex Corporation Methods for detection and quantification of small RNA
ES2565185T3 (es) 2008-04-18 2016-04-01 Collplant Ltd. Métodos de generación y de uso del procolágeno
GB0807161D0 (en) * 2008-04-18 2008-05-21 Danisco Process
US10150990B2 (en) 2008-04-21 2018-12-11 Roche Molecular Systems, Inc. Ribonucleotide tag nucleic acid detection
EP2444491B1 (en) 2008-04-21 2016-11-16 Novo Nordisk Healthcare Ag Hyperglycosylated human coagulation factor IX
WO2009130588A2 (en) * 2008-04-22 2009-10-29 Tripep Ab Immunogen platform
ZA201007564B (en) 2008-04-23 2012-01-25 Goodyear Tire & Rubber Isoprene synthase variants for improved microbial production of isoprene
BRPI0911551B8 (pt) 2008-04-24 2023-10-03 Monsanto Technology Llc Método para produzir planta de soja resistente a ferrugem asiática da soja (asr)
GB0807609D0 (en) * 2008-04-25 2008-06-04 Cancer Rec Tech Ltd Therapeutic compounds and their use
EP2281882A4 (en) 2008-04-25 2012-03-21 Toray Industries NUCLEIC ACID CONTAINING A CHIMERIC GENE FROM HEPATITIS TYPE C VIRUS
EP2113574A1 (en) 2008-04-28 2009-11-04 Biotype AG Substances and methods for a DNA based profiling assay
US8911948B2 (en) * 2008-04-30 2014-12-16 Integrated Dna Technologies, Inc. RNase H-based assays utilizing modified RNA monomers
US10227641B2 (en) 2008-04-30 2019-03-12 Integrated Dna Technologies, Inc. RNase H-based assays utilizing modified RNA monomers
EP2644709B1 (en) 2008-04-30 2014-12-17 Integrated Dna Technologies, Inc. RNase-H-based assays utilizing modified RNA monomers
WO2009137369A1 (en) * 2008-05-03 2009-11-12 Tufts Medical Center, Inc. Neonatal salivary genomics
EP3067694A1 (en) 2008-05-05 2016-09-14 Los Alamos National Security, LLC Lateral flow-based nucleic acid sample preparation device, integrated with passive fluid flow control
WO2009137807A2 (en) 2008-05-08 2009-11-12 Asuragen, Inc. Compositions and methods related to mirna modulation of neovascularization or angiogenesis
WO2009138877A2 (en) 2008-05-11 2009-11-19 Universiteit Stellenbosch Heterologous expression of fungal cellobiohydrolases in yeast
CA2723726C (en) 2008-05-13 2017-09-12 Michael M. Becker Inactivatable target capture oligomers for use in the selective hybridization and capture of target nucleic acid sequences
FI20085450A0 (fi) 2008-05-14 2008-05-14 Arto Orpana Menetelmä DNA-juosteen syntetisoimiseksi
CN102089444A (zh) 2008-05-14 2011-06-08 德玛泰克国际公司 利用核酸分析方法来诊断黑素瘤和太阳能雀斑
WO2010096036A2 (en) 2008-05-14 2010-08-26 Millennium Pharmaceuticals, Inc. Methods and kits for monitoring the effects of immunomodulators on adaptive immunity
WO2009140685A2 (en) * 2008-05-16 2009-11-19 Bristol-Myers Squibb Company Methods for identifying subjects with an increased likelihood of responding to dpp-iv inhibitors
EP2127751B1 (en) 2008-05-19 2012-05-16 Roche Diagnostics GmbH Improved cooler / heater arrangement with solid film lubricant
US8895240B2 (en) * 2008-05-19 2014-11-25 E I Du Pont De Nemours And Company Method, kit and system for collecting and processing samples for DNA and RNA detection
BRPI0908666B1 (pt) 2008-05-22 2021-06-15 Evogene Ltd Método de aumento do teor do óleo, do rendimento de sementes, da taxa de crescimento e/ou da biomassa de uma planta quando comparada a uma planta nativa, e, construção de ácido nucleico isolado
EP2163239A1 (de) * 2008-05-27 2010-03-17 Qiagen GmbH Produkte, die Biopartikel enthalten, Verfahren zu ihrer Herstellung
US9817001B2 (en) 2008-05-27 2017-11-14 Boston Heart Diagnostics Corporation Methods for determining LDL cholesterol treatment
EP2303293A1 (en) 2008-05-27 2011-04-06 Pluristem Ltd. Methods of treating inflammatory colon diseases
DE102008025328B4 (de) 2008-05-27 2013-10-17 DRK-Blutspendedienst Baden-Württemberg-Hessen gGmbH Zusammensetzungen und Verfahren zur Amplifikation von HI-Viren mittels Multiplex-PCR in multiplen Genombereichen
CA2725239C (en) 2008-05-27 2019-02-26 Trilink Biotechnologies Chemically modified nucleoside 5'-triphosphates for thermally initiated amplification of nucleic acid
US8722348B2 (en) 2008-05-28 2014-05-13 Wayne State University Method and composition for a protein transduction technology and its applications
AU2009253675A1 (en) 2008-05-28 2009-12-03 Genomedx Biosciences, Inc. Systems and methods for expression-based discrimination of distinct clinical disease states in prostate cancer
WO2009144718A1 (en) 2008-05-28 2009-12-03 Ramot At Tel Aviv University Ltd. Mesenchymal stem cells for the treatment of cns diseases
US20110212021A1 (en) 2008-05-30 2011-09-01 Slack Frank J Targeted oligonucleotide compositions for modifying gene expression
EP2297358A2 (en) 2008-05-30 2011-03-23 Gen-Probe Incorporated Compositions, kits and related methods for the detection and/or monitoring of salmonella
JP5740302B2 (ja) 2008-05-30 2015-06-24 ザ ユニバーシティー オブ ノースカロライナ アット チャペル ヒル 乳癌の予後を予測するための遺伝子発現プロフィール
US8208909B2 (en) 2008-06-02 2012-06-26 West Corporation System, apparatus and method for availing a mobile call of address information
JP2011522540A (ja) 2008-06-04 2011-08-04 セルラー ダイナミクス インターナショナル， インコーポレイテッド 非ウイルスアプローチを用いたｉＰＳ細胞の産生のための方法
EP2402462A1 (en) 2008-06-06 2012-01-04 F. Hoffmann-La Roche AG Internally controlled multiplex detection and quantification of microbial nucleic acids
EP2293800B1 (en) 2008-06-06 2016-10-05 Quark Pharmaceuticals, Inc. Compositions and methods for treatment of ear disorders
JP5492879B2 (ja) * 2008-06-06 2014-05-14 ダニスコ・ユーエス・インク 改善された性質を有するゲオバチルスステアロセレモフィリス（Ｇｅｏｂａｃｉｌｌｕｓｓｔｅａｒｏｔｈｅｒｍｏｐｈｉｌｕｓ）アルファアミラーゼ（ＡｍｙＳ）変異体
CA2726370A1 (en) 2008-06-06 2009-12-10 Danisco Us Inc. Compositions and methods comprising variant microbial proteases
EP3249056B1 (en) 2008-06-11 2019-04-10 GeneForm Technologies Limited Method of atp regeneration in a recombinase reaction
US9297046B2 (en) 2008-06-12 2016-03-29 Assistance Publique—Hopitaux de Paris TET2 as a new diagnostic and pronostic marker in hematopoietic neoplasms
WO2009150229A1 (en) 2008-06-12 2009-12-17 Institut National De La Sante Et De La Recherche Medicale (Inserm) Tet2 as a new diagnostic and pronostic marker in hematopoietic neoplasms
US20090311677A1 (en) * 2008-06-13 2009-12-17 Andrew Reeves Identification of contaminating bacteria in industrial ethanol fermentations
GB0810902D0 (en) 2008-06-13 2008-07-23 Astex Therapeutics Ltd New compounds
EP2235177B1 (en) * 2008-06-13 2012-07-18 RiboxX GmbH Method for enzymatic synthesis of chemically modified rna
WO2009155271A1 (en) * 2008-06-17 2009-12-23 Sigma-Aldrich Co. Real time polymerase chain reaction process using a universal detection system
WO2010033285A2 (en) 2008-06-26 2010-03-25 Spectrum Health Method for treating and preventing radiation damage using genetically modified mesenchymal stem cells
US20110082191A1 (en) * 2008-06-26 2011-04-07 Spectrum Health Innovations, LLC Method for treating or preventing radiation damage by in vivo gene therapy
WO2009158678A1 (en) 2008-06-27 2009-12-30 Children's Hospital & Research Center At Oakland Lipophilic nucleic acid delivery vehicle and methods of use therefor
EP2297357B1 (en) 2008-06-27 2012-10-31 Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute For Biomedical Research Prediction of antiviral therapy response
EP2623112B1 (en) 2008-06-27 2015-03-04 Zymogenetics, Inc. Soluble hybrid Fc gamma receptors and related methods
US9952211B2 (en) 2008-06-29 2018-04-24 Realbio Technologies Ltd. Liquid-transfer device particularly useful as a capturing device in a biological assay process
MX318543B (es) 2008-07-02 2014-03-18 Danisco Us Inc Composiciones y metodos para producir isopreno libre de hidrocarburos de c5 bajo condicion de desacoplamiento y/o intervalos de operacion seguros.
US20100120034A1 (en) * 2008-07-03 2010-05-13 Life Technologies Corporation Methylation analysis of mate pairs
US8216786B2 (en) 2008-07-09 2012-07-10 Celera Corporation Genetic polymorphisms associated with cardiovascular diseases, methods of detection and uses thereof
USD618820S1 (en) 2008-07-11 2010-06-29 Handylab, Inc. Reagent holder
US8097412B2 (en) * 2008-07-12 2012-01-17 Biodiagnostics, Inc. DNA-based test for detection of annual and intermediate ryegrass
USD787087S1 (en) 2008-07-14 2017-05-16 Handylab, Inc. Housing
EP4047367A1 (en) 2008-07-18 2022-08-24 Bio-Rad Laboratories, Inc. Method for detecting target analytes with droplet libraries
WO2010011281A2 (en) * 2008-07-22 2010-01-28 The Research Foundation Of State University Of New York Methods and compositions for the diagnosis and treatment of cancer
RU2515611C2 (ru) 2008-07-23 2014-05-20 Президент Энд Феллоуз Оф Гарвард Колледж Ингибиторы деацетилазы и их применение
US8580801B2 (en) * 2008-07-23 2013-11-12 Robert I. Henkin Phosphodiesterase inhibitor treatment
FR2934595B1 (fr) * 2008-07-29 2013-04-05 Biomerieux Sa Reactifs de marquage ayant un noyau pyridine portant une fonction diazomethyle, procedes de synthese de tels reactifs et procedes de detection de molecules biologiques
CA2638458A1 (en) * 2008-07-31 2010-01-31 Spartan Bioscience Inc. Thermal recycling by positioning relative to fixed-temperature source
CN102112157B (zh) * 2008-08-06 2013-05-29 诺沃-诺迪斯克保健股份有限公司 具有延长的体内效能的缀合蛋白
KR20100019220A (ko) * 2008-08-08 2010-02-18 삼성전자주식회사 열순환을 포함하는 다중 치환 증폭에 의하여 표적 핵산 서열을 증폭하는 방법
EP2320953B1 (en) 2008-08-08 2015-07-15 Genisphere, LLC Long-acting dna dendrimers and methods thereof
KR20110052681A (ko) * 2008-08-08 2011-05-18 스미스 디텍션 인크. Ｐｃｒ 검정을 위한 검출 알고리즘
EP2789695B1 (en) 2008-08-12 2019-10-30 Zinfandel Pharmaceuticals, Inc. Anti-Alzheimer's disease treatment of subjects identified by detecting the presence of a genetic variant in the TOMM40 gene at rs 10524523
CA2733642A1 (en) 2008-08-14 2010-02-18 Cephalon Australia Pty Ltd Anti-il-12/il-23 antibodies
EP3072972B1 (en) * 2008-08-18 2019-10-23 Evogene Ltd. Isolated polypeptides and polynucleotides useful for increasing nitrogen use efficiency, abiotic stress tolerance, yield and biomass in plants
ES2546732T3 (es) 2008-08-20 2015-09-28 Brainco Biopharma, S.L. STXBP1 como biomarcador psiquiátrico en un sistema de modelo murino y sus usos
US8912387B2 (en) * 2008-08-21 2014-12-16 E. I. Du Pont De Nemours And Company Genetic loci associated with head smut resistance in maize
EP2331547B1 (en) 2008-08-22 2014-07-30 Novartis AG Pyrrolopyrimidine compounds as cdk inhibitors
US20100068718A1 (en) 2008-08-22 2010-03-18 Hooper Dennis G Methods and Compositions for Identifying Yeast
EP2161345A1 (fr) 2008-08-25 2010-03-10 Institut National de la Recherche Agronomique Marqueurs génétiques pour la coloration de la viande
CN102203287B (zh) * 2008-08-26 2017-09-19 弗卢迪格姆公司 增加样本和/或靶通量的测定方法
US8198062B2 (en) 2008-08-29 2012-06-12 Dsm Ip Assets B.V. Hydrolases, nucleic acids encoding them and methods for making and using them
US8153391B2 (en) 2008-08-29 2012-04-10 Bunge Oils, Inc. Hydrolases, nucleic acids encoding them and methods for making and using them
US8357503B2 (en) 2008-08-29 2013-01-22 Bunge Oils, Inc. Hydrolases, nucleic acids encoding them and methods for making and using them
AU2009287165A1 (en) * 2008-08-29 2010-03-04 Symphogen A/S Method for cloning avian-derived antibodies
ES2581774T3 (es) 2008-08-29 2016-09-07 Janssen Biotech, Inc. Marcadores y métodos de evaluación y tratamiento de colitis ulcerosa y trastornos relacionados mediante un panel de 20 genes
MX2011002328A (es) 2008-09-02 2011-05-19 Pluristem Ltd Celulas adherentes del tejido de placenta y su uso en terapia.
US8367392B2 (en) * 2008-09-05 2013-02-05 Transalgae Ltd. Genetic transformation of algal and cyanobacteria cells by microporation
WO2010030716A1 (en) * 2008-09-10 2010-03-18 Igor Kutyavin Detection of nucleic acids by oligonucleotide probes cleaved in presence of endonuclease v
WO2010029545A2 (en) 2008-09-11 2010-03-18 Ben Gurion University Of The Negev Research And Development Authority Compositions and methods for treating s. pneumoniae infection
TWI516501B (zh) 2008-09-12 2016-01-11 禮納特神經系統科學公司 Ｐｃｓｋ９拮抗劑類
EP2331703A2 (en) * 2008-09-12 2011-06-15 Promega Corporation Assessing expression of endogenous and exogenous genes
RU2535966C2 (ru) 2008-09-12 2014-12-20 Криопрашис Криобиоложия Лтда. Клеточная терапия ишемической ткани
EP3323881A1 (en) 2008-09-15 2018-05-23 Danisco US Inc. Systems using cell culture for production of isoprene
MY156562A (en) * 2008-09-15 2016-02-26 Danisco Us Inc Increased isoprene production using the archaeal lower mevalonate pathway
US20100184178A1 (en) * 2008-09-15 2010-07-22 Zachary Quinn Beck Increased isoprene production using mevalonate kinase and isoprene synthase
SG169614A1 (en) 2008-09-15 2011-04-29 Goodyear Tire & Rubber Conversion of prenyl derivatives to isoprene
EP2347254A2 (en) 2008-09-16 2011-07-27 Ibis Biosciences, Inc. Sample processing units, systems, and related methods
US8962247B2 (en) 2008-09-16 2015-02-24 Sequenom, Inc. Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non invasive prenatal diagnoses
US8476013B2 (en) * 2008-09-16 2013-07-02 Sequenom, Inc. Processes and compositions for methylation-based acid enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses
EP2344893B1 (en) 2008-09-16 2014-10-15 Ibis Biosciences, Inc. Microplate handling systems and methods
WO2010033604A2 (en) * 2008-09-18 2010-03-25 X-Bar Diagnostic System, Inc. Fully automated portable dna detection system
US20110159499A1 (en) * 2009-11-25 2011-06-30 Quantalife, Inc. Methods and compositions for detecting genetic material
EP3670524A1 (en) 2008-09-24 2020-06-24 Tel HaShomer Medical Research Infrastructure and Services Ltd. Peptides and compositions for prevention of cell adhesion and methods of using same
EP2172563A1 (en) 2008-09-24 2010-04-07 bioMérieux S.A. Method for lowering the dependency towards sequence variation of a nucleic acid target in a diagnostic hybridization assay
BRPI0920891B1 (pt) 2008-09-25 2023-01-10 Danisco Us Inc Mistura de alfa-amilase e método para produção de um açúcar fermentável
EP2344672B8 (en) 2008-09-25 2014-12-24 SureGene LLC Genetic markers for optimizing treatment for schizophrenia
EP2346995B1 (en) 2008-09-26 2018-11-07 Tocagen Inc. Gene therapy vectors and cytosine deaminases
US8470541B1 (en) 2008-09-27 2013-06-25 Boston Heart Diagnostics Corporation Methods for separation and immuno-detection of biomolecules, and apparatus related thereto
CA2738474C (en) 2008-09-29 2020-05-12 Monsanto Technology Llc Soybean transgenic event mon87705 and methods for detection thereof
JP5846912B2 (ja) 2008-09-29 2016-01-20 ビュータマックス・アドバンスド・バイオフューエルズ・エルエルシー 細菌性［２Ｆｅ−２Ｓ］ジヒドロキシ酸デヒドラターゼの同定および使用
EP2337869B1 (en) 2008-09-29 2015-08-19 Butamax Advanced Biofuels Llc Enhanced pyruvate to 2,3-butanediol conversion in lactic acid bacteria
MX2011003313A (es) * 2008-09-29 2011-06-16 Butamax Tm Advanced Biofuels Actividad enzimatica de fe-s heterologa aumentada en levadura.
CA2736729A1 (en) 2008-09-29 2010-04-01 Ben Gurion University Of The Negev Research And Development Authority Amyloid beta-peptides and methods of use thereof
US8637281B2 (en) * 2008-09-29 2014-01-28 Butamax(Tm) Advanced Biofuels Llc Enhanced dihydroxy-acid dehydratase activity in lactic acid bacteria
US9090948B2 (en) 2008-09-30 2015-07-28 Abbott Molecular Inc. Primers and probes for detecting human papillomavirus and human beta globin sequences in test samples
US20100082438A1 (en) * 2008-10-01 2010-04-01 Ronnie Jack Garmon Methods and systems for customer performance scoring
BRPI0913818A2 (pt) 2008-10-03 2017-03-28 Agrisoma Biosciences Inc método de produção de plantas transgênicas, planta transgênica e método de produção de óleo
WO2010037208A1 (en) * 2008-10-03 2010-04-08 Dow Agrosciences Llc Production of products of pharmaceutical interest in plant cell cultures
MX2011003700A (es) 2008-10-06 2011-11-29 Abbott Lab Genes de delta-8 desaturasa, enzimas codificadas por los mismos y usos de los mismos.
BRPI0920041A2 (pt) 2008-10-06 2017-06-27 Univ Chicago composições e processos relacionados às proteínas eap, emp e/ou adsa bacterianas
IL194617A0 (en) * 2008-10-07 2009-11-18 Opticul Diagnostics Ltd Device and method for spectrometric identification of antibiotic resistance microbes
US20100124756A1 (en) * 2008-10-10 2010-05-20 Sandip Ray Collection of biomarkers for diagnosis and monitoring of alzheimer's disease in body fluids
US9234226B2 (en) 2008-10-14 2016-01-12 Wayne M. Barnes In vitro recombination methods using 5′ exonuclease
US9458472B2 (en) * 2008-10-15 2016-10-04 Massachusetts Institute Of Technology Detection and destruction of cancer cells using programmed genetic vectors
EP2177271B8 (en) 2008-10-15 2019-12-18 F. Hoffmann-La Roche AG Magnetic separation system comprising flexible magnetic pins and corresponding method
US20100301398A1 (en) 2009-05-29 2010-12-02 Ion Torrent Systems Incorporated Methods and apparatus for measuring analytes
US8017327B2 (en) 2008-10-23 2011-09-13 Honeywell International Inc. Single nucleotide polymorphism genotyping detection via the real-time invader assay microarray platform
US20100105032A1 (en) 2008-10-23 2010-04-29 Tao Pan Highly sensitive multiplex single nucleotide polymorphism and mutation detection using real time ligase chain reaction microarray
US8058005B2 (en) 2008-10-23 2011-11-15 Honeywell International Inc. Method for single nucleotide polymorphism and mutation detection using real time polymerase chain reaction microarray
US20100120105A1 (en) * 2008-10-27 2010-05-13 Butamax (Tm) Advanced Biofuels Llc Carbon pathway optimized production hosts for the production of isobutanol
MX2011003575A (es) 2008-10-30 2011-04-21 Evogene Ltd Polinucleotidos y polipeptidos aislados y metodos para utilizarlos para aumentar el rendimiento de la planta, biomasa, tasa de crecimiento, vigor, contenido de aceite, tolerancia al estres abiotico de las plantas y eficacia en el uso de nitrogeno.
BRPI0919881B1 (pt) 2008-10-31 2021-09-08 Centocor Ortho Biotech Inc Proteína de arcabouço e seu método de geração, biblioteca e seu método de construção, molécula de ácido nucleico, vetor de ácido nucleico, célula hospedeira, composição, dispositivo médico e artigo de fabricação
CA2739461A1 (en) * 2008-10-31 2010-05-06 Abbott Laboratories Genomic classification of malignant melanoma based on patterns of gene copy number alterations
JP5391279B2 (ja) * 2008-10-31 2014-01-15 アッヴィ・インコーポレイテッド １種以上の医薬組成物の有効性を試験することに使用する癌細胞系のパネルを構築するための方法
US8498822B2 (en) * 2008-10-31 2013-07-30 Abbvie Inc. Genomic classification of colorectal cancer based on patterns of gene copy number alterations
JP5632382B2 (ja) * 2008-10-31 2014-11-26 アッヴィ・インコーポレイテッド 遺伝子コピー数変化のパターンに基づいた非小細胞肺癌のゲノム分類
US9023633B2 (en) 2008-11-03 2015-05-05 Kapa Biosystems Chimeric DNA polymerases
US10457968B2 (en) 2008-11-03 2019-10-29 Kapa Biosystems, Inc. Modified type A DNA polymerases
US8628927B2 (en) 2008-11-07 2014-01-14 Sequenta, Inc. Monitoring health and disease status using clonotype profiles
US9365901B2 (en) 2008-11-07 2016-06-14 Adaptive Biotechnologies Corp. Monitoring immunoglobulin heavy chain evolution in B-cell acute lymphoblastic leukemia
US8748103B2 (en) 2008-11-07 2014-06-10 Sequenta, Inc. Monitoring health and disease status using clonotype profiles
US8236503B2 (en) 2008-11-07 2012-08-07 Sequenta, Inc. Methods of monitoring conditions by sequence analysis
US9506119B2 (en) 2008-11-07 2016-11-29 Adaptive Biotechnologies Corp. Method of sequence determination using sequence tags
US9394567B2 (en) 2008-11-07 2016-07-19 Adaptive Biotechnologies Corporation Detection and quantification of sample contamination in immune repertoire analysis
US9095592B2 (en) 2008-11-07 2015-08-04 The Research Foundation For The State University Of New York Bruton's tyrosine kinase as anti-cancer drug target
US9528160B2 (en) 2008-11-07 2016-12-27 Adaptive Biotechnolgies Corp. Rare clonotypes and uses thereof
JP5805538B2 (ja) 2008-11-07 2015-11-04 リサーチ ディベロップメント ファウンデーション Ｃｒｉｐｔｏ／ＧＳＰ７８複合体形成およびシグナル伝達を阻害するための組成物および方法
US8710104B2 (en) * 2008-11-07 2014-04-29 Triact Therapeutics, Inc. Catecholic butanes and use thereof for cancer therapy
BR122013014156A2 (pt) 2008-11-11 2015-07-14 Danisco Us Inc Composição de limpeza compreendendo variantes de subtilisina, bem como processo de limpeza
CN102209777B (zh) 2008-11-11 2014-02-12 丹尼斯科美国公司 包含枯草蛋白酶变体的组合物和方法
WO2010056634A1 (en) 2008-11-11 2010-05-20 Danisco Us Inc. Compositions and methods comprising a subtilisin variant
BR122013014157A2 (pt) 2008-11-11 2018-11-13 Danisco Us Inc. composições de limpeza compreendendo variantes de subtilisina de bacillus, bem como processo de limpeza
US8828694B2 (en) * 2008-11-13 2014-09-09 Butamax Advanced Biofuels Llc Production of isobutanol in yeast mitochondria
US8465964B2 (en) 2008-11-13 2013-06-18 Butamax (TM) Advanced Biofules LLC Increased production of isobutanol in yeast with reduced mitochondrial amino acid biosynthesis
US20110229892A1 (en) 2008-11-17 2011-09-22 Yehuda G Assaraf Method for predicting a patient's responsiveness to anti-folate therapy
US8288124B2 (en) 2008-11-20 2012-10-16 Abbott Laboratories Cloning, expression and purification of recombinant porcine intrinsic factor for use in diagnostic assay
US8346485B2 (en) 2008-11-25 2013-01-01 Quest Diagnostics Investments Incorporated Methods and apparatuses for estimating initial target nucleic acid concentration in a sample by modeling background signal and cycle-dependent amplification efficiency of a polymerase chain reaction
US9133475B2 (en) 2008-11-26 2015-09-15 Board Of Trustees Of Michigan State University Aphid resistant soybean plants
WO2010061393A1 (en) 2008-11-30 2010-06-03 Compugen Ltd. He4 variant nucleotide and amino acid sequences, and methods of use thereof
WO2010064231A1 (en) 2008-12-02 2010-06-10 Tel Hashomer Medical Research Infrastructure And Services Ltd. Methods of analyzing a-i rna editing and nucleic acid constructs capable of same
US8652823B2 (en) * 2008-12-03 2014-02-18 Butamax(Tm) Advanced Biofuels Llc Strain for butanol production with increased membrane unsaturated trans fatty acids
WO2010064247A1 (en) 2008-12-03 2010-06-10 Tel Hashomer Medical Research Infrastructure And Services Ltd. Methods and kits for determining predisposition to cancer
US8367340B2 (en) * 2008-12-03 2013-02-05 University Of Maryland, Baltimore Prognostic tools to predict the efficacy of drug treatment targeting chromatin DNA or enzymes acting on DNA
ES2629630T3 (es) 2008-12-04 2017-08-11 Curna, Inc. Tratamiento de enfermedades relacionadas con eritropoyetina (EPO) mediante inhibición del transcrito antisentido natural a EPO
EP2370582B1 (en) 2008-12-04 2017-05-10 CuRNA, Inc. Treatment of tumor suppressor gene related diseases by inhibition of natural antisense transcript to the gene
US8927511B2 (en) * 2008-12-04 2015-01-06 Curna, Inc. Treatment of vascular endothelial growth factor (VEGF) related diseases by inhibition of natural antisense transcript to VEGF
WO2010064248A2 (en) 2008-12-05 2010-06-10 Yeda Research And Development Co. Ltd. Methods of diagnosing and treating motor neuron diseases
JP5651125B2 (ja) 2008-12-10 2015-01-07 デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド Ｍｅｋ阻害剤に対する耐性を付与するｍｅｋ突然変異
WO2010068702A2 (en) * 2008-12-10 2010-06-17 Illumina, Inc. Methods and compositions for hybridizing nucleic acids
WO2010068102A1 (en) 2008-12-10 2010-06-17 Monsanto Invest N.V. Novel plant virus
EP2356198B1 (en) 2008-12-12 2016-03-16 E. I. du Pont de Nemours and Company Process for making linear dicarboxylic acids from renewable resources
WO2010070366A1 (en) 2008-12-15 2010-06-24 Debreceni Egyetem Cytometric method for the comparative analysis of the length of pcr products and uses of this method
EP2358862B1 (en) 2008-12-18 2017-08-02 E. I. du Pont de Nemours and Company Reducing byproduction of malonates in a fermentation process
US8362318B2 (en) * 2008-12-18 2013-01-29 Board Of Trustees Of Michigan State University Enzyme directed oil biosynthesis in microalgae
WO2010071610A1 (en) 2008-12-19 2010-06-24 Agency For Science, Technology And Research (A*Star) Severe chikungunya biomarkers
US8388904B1 (en) 2008-12-22 2013-03-05 Reactive Surfaces, Ltd., Llp Equipment decontamination system and method
WO2010075441A1 (en) 2008-12-22 2010-07-01 Trustees Of Boston University Modular nucleic acid-based circuits for counters, binary operations, memory, and logic
CN102439171B (zh) 2008-12-22 2017-07-14 犹他大学研究基金会 单色多重定量pcr
US8795992B2 (en) 2008-12-29 2014-08-05 Butamax Advanced Biofuels Llc Yeast with increased butanol tolerance involving cell wall integrity pathway
CA2748121C (en) 2008-12-29 2017-12-12 Tel Hashomer Medical Research, Infrastructure And Services Ltd. Peptides and compositions for prevention of cell adhesion and methods of using same
US20120009148A1 (en) 2008-12-29 2012-01-12 Yissum Research Development Company Of The Hebrew University Of Jerusalem, Ltd. Methods of predicting responsiveness to interferon treatment and treating hepatitis c infection
US8455225B2 (en) * 2008-12-29 2013-06-04 Butamax Advanced Biofuels Llc Yeast with increased butanol tolerance involving high osmolarity/glycerol response pathway
US8557562B2 (en) * 2008-12-29 2013-10-15 Butamax(Tm) Advanced Biofuels Llc Yeast with increased butanol tolerance involving filamentous growth response
EP2373792B1 (en) 2008-12-29 2016-11-02 Evogene Ltd. Polynucleotides, polypeptides encoded thereby, and methods of using same for increasing abiotic stress tolerance, biomass and/or yield in plants expressing same
EP2910647A1 (en) 2008-12-30 2015-08-26 Gen-Probe Incorporated Compositions, kits and related methods for the detection and/or monitoring of listeria
CN102333866B (zh) 2008-12-30 2015-04-29 丹尼斯科美国公司 生产异戊二烯和共同产物的方法
WO2010076794A1 (en) 2008-12-31 2010-07-08 Technion Research & Development Foundation Ltd. Method of denitrifying brine and systems capable of same
FR2940805B1 (fr) 2009-01-05 2015-10-16 Biomerieux Sa Procede d'amplification et/ou de detection d'acides nucleiques, kits et utilisations de ce procede
WO2010080769A2 (en) 2009-01-06 2010-07-15 Arresto Biosciences, Inc. Chemotherapeutic methods and compositions
EP2894226B1 (en) 2009-01-08 2021-04-14 Bio-Rad Laboratories, Inc. Methods and compositions for improving efficiency of nucleic acids amplification reactions
EP2382328A2 (en) 2009-01-09 2011-11-02 The Regents of the University of Michigan Recurrent gene fusions in cancer
ES2726702T3 (es) 2009-01-15 2019-10-08 Adaptive Biotechnologies Corp Perfilado de la inmunidad adaptativa y métodos para la generación de anticuerpos monoclonales
JP5816097B2 (ja) 2009-01-22 2015-11-18 ノヴォ・ノルディスク・ヘルス・ケア・アーゲー 安定な成長ホルモン化合物
EP2391635B1 (en) 2009-01-28 2017-04-26 Epimmune Inc. Pan-dr binding polypeptides and uses thereof
CA2749945A1 (en) * 2009-01-31 2010-08-05 Abbott Laboratories Markers to predict and monitor response to aurora kinase b inhibitor therapy
IL196820A0 (en) 2009-02-01 2009-11-18 Yissum Res Dev Co Devitalized, acellular scaffold matrices derived from micro-organs seeded with various cells
US8691760B2 (en) 2009-02-02 2014-04-08 Ramot At Tel-Aviv University Peptides, pharmaceutical compositions comprising same and uses thereof
WO2010086828A2 (en) 2009-02-02 2010-08-05 Rinat Neuroscience Corporation Agonist anti-trkb monoclonal antibodies
US8685648B2 (en) 2009-02-03 2014-04-01 Biohelix Corporation Endonuclease-enhanced helicase-dependent amplification
WO2010089707A1 (en) 2009-02-04 2010-08-12 Yeda Research And Development Co. Ltd. Methods and kits for determining sensitivity or resistance of prostate cancer to radiation therapy
US20100267092A1 (en) * 2009-02-09 2010-10-21 Frederic Zenhausern Components
ES2544265T3 (es) 2009-02-11 2015-08-28 Orion Genomics, Llc Combinaciones de polimorfismos para determinar la expresión específica de alelo de IGF2
CA2751293A1 (en) 2009-02-11 2010-08-19 Abbott Laboratories Methods and compositions for identifying, classifying and monitoring subject having bcl-2 family inhibitor-resistant tumors and cancers
JP2012517238A (ja) 2009-02-11 2012-08-02 カリス エムピーアイ インコーポレイテッド 腫瘍の分子プロファイリング法
EP2396803A4 (en) 2009-02-12 2016-10-26 Ibis Biosciences Inc IONIZATION PROBE ASSEMBLIES
EP2396011B1 (en) 2009-02-12 2016-04-13 Janssen Biotech, Inc. Fibronectin type iii domain based scaffold compositions, methods and uses
ES2560107T3 (es) 2009-02-12 2016-02-17 Curna, Inc. Tratamiento de enfermedades relacionadas con el factor neurotrófico derivado de cerebro (BDNF) por inhibición de transcrito antisentido natural para BDNF
US9399219B2 (en) 2009-02-13 2016-07-26 Frank Leo Spangler Thermal Array
EP2218794A1 (en) 2009-02-13 2010-08-18 Alphagenics International SA Detection of instability in regions of genomic DNA containing simple tandem repeats
US20120094288A1 (en) 2009-02-17 2012-04-19 Murdoch Childrens Research Institute Assay for determining epigenetic profiles of markers of fragile x alleles
CA2752818A1 (en) 2009-02-26 2010-09-02 Codexis, Inc. Beta-glucosidase variant enzymes and related polynucleotides
WO2010099378A2 (en) 2009-02-26 2010-09-02 Gen-Probe Incorporated Assay for detection of human parvovirus nucleic acid
US20110311494A1 (en) 2009-02-26 2011-12-22 Tel Hashomer Medical Research Infrastructure And Services Ltd. Methods of reprogramming renal cells
US8614085B2 (en) 2009-02-27 2013-12-24 Butamax(Tm) Advanced Biofuels Llc Yeast with increased butanol tolerance involving a multidrug efflux pump gene
US8642834B2 (en) 2009-02-27 2014-02-04 OSI Pharmaceuticals, LLC Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation
WO2010099138A2 (en) 2009-02-27 2010-09-02 Osi Pharmaceuticals, Inc. Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation
EP2401613A2 (en) 2009-02-27 2012-01-04 OSI Pharmaceuticals, LLC Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation
WO2010100595A2 (en) 2009-03-02 2010-09-10 Evogene Ltd. Isolated polynucleotides and polypeptides, and methods of using same for increasing plant yield and/or agricultural characteristics
US20110171749A1 (en) * 2009-03-02 2011-07-14 Board Of Trustees Of Michigan State University Nanoparticle tracer-based electrochemical dna sensor for detection of pathogens-amplification by a universal nano-tracer (aunt)
ES2564265T3 (es) 2009-03-09 2016-03-21 Ramot At Tel-Aviv University Ltd. Composiciones para prevención y tratamiento de enfermedades neurodegenerativas
US8039215B2 (en) 2009-03-10 2011-10-18 Roche Molecular Systems, Inc. Multiplex quantitative nucleic acid amplification and melting assay
US20120107267A1 (en) 2009-03-11 2012-05-03 Novo Nordisk A/S Interleukin-21 variants having antagonistic binding to the il-21 receptor
WO2010103517A1 (en) 2009-03-12 2010-09-16 Rappaport Family Institute For Research In The Medical Sciences Soluble compositions for the treatment of cxcr3-ligand associated diseases
US9034605B2 (en) 2009-03-12 2015-05-19 Brandeis University Reagents and methods for PCR
US8404242B2 (en) 2009-03-16 2013-03-26 Atyr Pharma, Inc. Compositions and methods comprising histidyl-tRNA synthetase splice variants having non-canonical biological activities
CA2755409C (en) 2009-03-16 2019-04-30 Joseph Collard Treatment of nuclear factor (erythroid-derived 2)-like 2 (nrf2) related diseases by inhibition of natural antisense transcript to nrf2
EP2408863B1 (en) 2009-03-16 2018-01-10 Promega Corporation Nucleic acid binding dyes and uses therefor
SI3260136T1 (sl) 2009-03-17 2021-05-31 Theraclone Sciences, Inc. Humani imunodeficientni virus (HIV)-nevtralizirajoča protitelesa
JP5904935B2 (ja) 2009-03-17 2016-04-20 クルナ・インコーポレーテッド デルタ様１ホモログ（ｄｌｋ１）に対する天然アンチセンス転写物の抑制によるｄｌｋ１関連疾患の治療
EP2408908B1 (en) 2009-03-17 2015-05-27 Codexis, Inc. Variant endoglucanases and related polynucleotides
EP2408936A4 (en) * 2009-03-18 2013-01-30 Sequenom Inc USE OF HEAT-STAINED ENDONUCLEASES FOR THE PREPARATION OF REPORTER MOLECULES
US8481698B2 (en) * 2009-03-19 2013-07-09 The President And Fellows Of Harvard College Parallel proximity ligation event analysis
CA2755639C (en) 2009-03-19 2018-09-25 Martek Biosciences Corporation Polyunsaturated fatty acid synthase nucleic acid molecules and polypeptides, compositions, and methods of making and uses thereof
CN104922676B (zh) 2009-03-20 2019-03-12 Clsn实验室股份有限公司 聚胺衍生物
GB0904957D0 (en) 2009-03-23 2009-05-06 Univ Erasmus Medical Ct Tumour gene profile
EP3415235A1 (en) 2009-03-23 2018-12-19 Raindance Technologies Inc. Manipulation of microfluidic droplets
CN102449171B (zh) * 2009-03-24 2015-12-02 奥斯瑞根公司 对fmr1和fmr2基因5’非翻译区进行表征的pcr方法
US20100248239A1 (en) * 2009-03-24 2010-09-30 Mayo Foundation For Medical Education And Research Methods and materials for detecting fragile x mutations
US8063193B2 (en) 2009-03-27 2011-11-22 Abbott Laboratories Nucleotide and amino acid sequences encoding an exported protein 1 derived from Plasmodium vivax and uses thereof
CN107375919B (zh) 2009-03-27 2022-07-29 台湾地区“中央研究院” 抗病毒免疫的方法和组合物
TW201039841A (en) 2009-03-27 2010-11-16 Gojo Ind Inc Compositions and methods for screening and using compounds antagonizing spore-surface interactions
GB0905325D0 (en) 2009-03-30 2009-05-13 Selex Sensors & Airborne Sys Detection system
EP3604510A1 (en) 2009-03-30 2020-02-05 Portola Pharmaceuticals, Inc. Antidotes for factor xa inhibitors and methods of using the same
EP2414542B1 (en) 2009-03-30 2017-08-30 Tel HaShomer Medical Research Infrastructure and Services Ltd. Methods of predicting clinical course and treating multiple sclerosis
US9393564B2 (en) 2009-03-30 2016-07-19 Ibis Biosciences, Inc. Bioagent detection systems, devices, and methods
DK3495498T3 (da) 2009-03-30 2022-01-17 Illumina Inc Genekspressionsanalyse i enkeltceller
BRPI1010239A2 (pt) 2009-03-31 2016-10-11 Codexis Inc endoglucanases aprimoradas, derivados e seus usos
MX2011010041A (es) 2009-04-01 2011-11-18 Danisco Us Inc Composiciones y metodos que comprenden variantes de alfa-amilasa con propiedades alteradas.
CN102439177B (zh) * 2009-04-02 2014-10-01 弗卢伊蒂格姆公司 用于对目标核酸进行条形码化的多引物扩增方法
CN202830041U (zh) * 2009-04-03 2013-03-27 Illumina公司 用于加热生物样本的设备
EP3964586A1 (en) 2009-04-03 2022-03-09 Sequenom, Inc. Nucleic acid preparation compositions and methods
PL3281947T3 (pl) 2009-04-03 2020-07-27 The University Of Chicago Kompozycje i sposoby związane z wariantami białka A (SpA)
US20100272824A1 (en) * 2009-04-16 2010-10-28 The Texas A&M University System Compositions and methods for preventing and monitoring disease
EP2272327A1 (en) 2009-04-16 2011-01-12 Schillinger Genetics, Inc. Soybeans having high germination rates and ultra-low raffinose and stachyose content
KR101815716B1 (ko) 2009-04-22 2018-01-05 인디애나 유니버시티 리서치 앤드 테크놀로지 코퍼레이션 만성 폐쇄성 폐 질환 및 천식의 치료에 사용하기 위한 조성물
EP2421966A2 (en) 2009-04-23 2012-02-29 Danisco US Inc. Three-dimensional structure of isoprene synthase and its use thereof for generating variants
CA2759681C (en) 2009-04-24 2019-09-17 Kathleen M. Tatti Selective detection of bordetella species
WO2010123626A1 (en) 2009-04-24 2010-10-28 University Of Southern California Cd133 polymorphisms and expression predict clinical outcome in patients with cancer
GB0908770D0 (en) 2009-04-24 2009-07-01 Danisco Method
EP2256215A1 (en) 2009-04-30 2010-12-01 Steffen Mergemeier Assay system using a nuclease activity of a nucleic acid polymerase
KR20180077322A (ko) 2009-04-30 2018-07-06 텔 하쇼머 메디컬 리서치 인프라스트럭쳐 앤드 서비시스 리미티드． 항-ｃｅａｃａｍ1 항체들과 이를 이용하는 방법들
CA2760439A1 (en) 2009-04-30 2010-11-04 Good Start Genetics, Inc. Methods and compositions for evaluating genetic markers
EP2427205A2 (en) 2009-05-04 2012-03-14 INSERM - Institut National de la Santé et de la Recherche Médicale Par2 agonists for use in the treatment or prevention of influenza virus type a infections
EP2427203B1 (en) 2009-05-05 2018-10-17 Novimmune S.A. Anti-il-17f antibodies and use thereof
CN102459596B (zh) 2009-05-06 2016-09-07 库尔纳公司 通过针对脂质转运和代谢基因的天然反义转录物的抑制治疗脂质转运和代谢基因相关疾病
KR101722541B1 (ko) 2009-05-06 2017-04-04 큐알엔에이, 인크. Ｔｔｐ에 대한 천연 안티센스 전사체의 억제에 의한 트리스테트라프롤린 관련된 질환의 치료
EP2249140B1 (en) 2009-05-07 2018-06-27 F. Hoffmann-La Roche AG Method for excising biological samples on a solid support
CA2761248C (en) 2009-05-08 2023-03-14 Joseph Collard Treatment of dystrophin family related diseases by inhibition of natural antisense transcript to dmd family
CN102482345A (zh) 2009-05-13 2012-05-30 航道生物技术有限责任公司 针对流感病毒的中和分子
US20100291606A1 (en) * 2009-05-13 2010-11-18 Board Of Regents, The University Of Texas System SCREENING SYSTEM FOR DETECTING INHIBITORS OF HIV INTEGRASE-LEDGF/p-75 INTERACTION
CA2761943A1 (en) * 2009-05-14 2010-11-18 Streck, Inc. Sample processing cassette, system, and method
ES2507145T3 (es) 2009-05-14 2014-10-14 Arizona Board Of Regents On Behalf Of University Of Arizona Diagnóstico y tratamientos del carcinoma, basado en el genotipo de ODC1
US20120208713A1 (en) 2009-05-15 2012-08-16 Josh Nickols Methods and compositions relating to fusions of alk for diagnosing and treating cancer
ES2664590T3 (es) 2009-05-18 2018-04-20 Curna, Inc. Tratamiento de enfermedades relacionadas con factores de reprogramación por inhibición del tránscrito antisentido natural a un factor de reprogramación
US20120058222A1 (en) 2009-05-19 2012-03-08 Danisco A/S Use
WO2010134073A1 (en) 2009-05-19 2010-11-25 Zetiq Technologies Ltd. Kits for and methods of differential staining of cervical cancer cells and/or tissues
US20100299773A1 (en) * 2009-05-20 2010-11-25 Monsanto Technology Llc Methods and compositions for selecting an improved plant
US9695403B2 (en) 2009-05-21 2017-07-04 Syngenta Participations Ag Phytases, nucleic acids encoding them and methods for making and using them
US8895527B2 (en) 2009-05-22 2014-11-25 Curna, Inc. Treatment of transcription factor E3 (TFE3) and insulin receptor substrate 2(IRS2) related diseases by inhibition of natural antisense transcript to TFE3
GB0908905D0 (en) 2009-05-26 2009-07-01 Sentinel Oncology Ltd Pharmaceutical compounds
WO2010137021A2 (en) 2009-05-27 2010-12-02 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Method of generating connective tissue
WO2010137013A1 (en) 2009-05-27 2010-12-02 Ramot At Tel Aviv University Ltd. Crystallized photosystem i units from the pea plant and their use in solid state devices
WO2010136232A1 (en) 2009-05-28 2010-12-02 Fundació Institut De Recerca De L´Hospital Universitari Vall D'hebron In vitro method suitable for patients suffering from cis for the early diagnosis or prognosis of multiple sclerosis
WO2010138806A2 (en) 2009-05-28 2010-12-02 Curna, Inc. Treatment of antiviral gene related diseases by inhibition of natural antisense transcript to an antiviral gene
WO2010138187A1 (en) 2009-05-29 2010-12-02 Ion Torrent Systems Incorporated Scaffolded nucleic acid polymer particles and methods of making and using
US20120261274A1 (en) 2009-05-29 2012-10-18 Life Technologies Corporation Methods and apparatus for measuring analytes
US8776573B2 (en) 2009-05-29 2014-07-15 Life Technologies Corporation Methods and apparatus for measuring analytes
WO2010141546A1 (en) 2009-06-02 2010-12-09 University Of Miami Diagnostic transcriptomic biomakers in inflammatory cardiomyopathies
KR101252507B1 (ko) * 2009-06-05 2013-04-09 가톨릭대학교 산학협력단 실시간 중합효소연쇄반응을 이용한 ｈｌａ 대립유전자 자동검사 키트
KR101772860B1 (ko) 2009-06-05 2017-08-30 셀룰러 다이내믹스 인터내셔널, 인코포레이티드 Ｔ 세포 및 조혈 세포의 재프로그래밍
EP2440214A4 (en) 2009-06-08 2013-07-31 Quark Pharmaceuticals Inc METHODS OF TREATING CHRONIC RENAL DISEASE
PT2264183T (pt) 2009-06-09 2017-03-14 Gendiag Exe Sl Marcadores de risco para doença cardiovascular
EP2261242A1 (en) 2009-06-10 2010-12-15 Universite Catholique De Louvain Aspartate-N-acetyltransferase enzyme, diagnostic method and therapeutic method
ES2773985T3 (es) 2009-06-10 2020-07-16 Evogene Ltd Polinucleótidos y polipéptidos aislados, y métodos para usar los mismos para incrementar la eficiencia en el uso de nitrógeno, rendimiento, tasa de crecimiento, vigor, biomasa, contenido de aceite, y/o tolerancia al estrés abiótico
EP2440922B1 (en) 2009-06-12 2016-08-10 Vaccine Technologies, Incorporated Methods for diagnostic assays for measuring cell mediated immune response
AR077042A1 (es) 2009-06-12 2011-07-27 Danisco Metodo para tratar una composicion que contiene pirofiofitina
CN102573883A (zh) 2009-06-12 2012-07-11 疫苗技术公司 用于促进细胞-介导的免疫应答的方法和组合物
CA2707296A1 (en) * 2009-06-12 2010-12-12 Richard T. Scott, Jr. Method for relative quantitation of chromosomal dna copy number in a single or few cells
EP2443256A1 (en) 2009-06-15 2012-04-25 BG Research Ltd Nucleic acid detection
JP5944311B2 (ja) 2009-06-16 2016-07-05 クルナ・インコーポレーテッド コラーゲン遺伝子に対する天然アンチセンス転写物の抑制によるコラーゲン遺伝子関連疾患の治療
US8951981B2 (en) 2009-06-16 2015-02-10 Curna, Inc. Treatment of paraoxonase 1 (PON1) related diseases by inhibition of natural antisense transcript to PON1
US9050276B2 (en) 2009-06-16 2015-06-09 The Trustees Of Columbia University In The City Of New York Autism-associated biomarkers and uses thereof
EP2443235A4 (en) 2009-06-16 2013-07-31 Codexis Inc ß-glucosidase VARIANTS
EP2443139B1 (en) 2009-06-16 2016-08-10 Codexis, Inc. Beta-glucosidase variant enzymes and related polynucleotides
WO2010146511A1 (en) 2009-06-17 2010-12-23 Pfizer Limited Treatment of overactive bladder
TW201120213A (en) 2009-06-17 2011-06-16 Danisco Us Inc Polymerization of isoprene from renewable resources
TWI434921B (zh) 2009-06-17 2014-04-21 Danisco Us Inc 從生物異戊二烯組合物製造燃料成分之方法及系統
TWI427149B (zh) * 2009-06-17 2014-02-21 Danisco Us Inc 使用ｄｘｐ及ｍｖａ途徑之改良之異戊二烯製造
CN102686610A (zh) 2009-06-18 2012-09-19 辉瑞公司 抗刻缺蛋白-1抗体
EP2444493A4 (en) 2009-06-19 2013-02-20 Kirin Holdings Kk PROTEIN OF NOVEL PRENYLATIONENZYM ACTIVITY AND THIS CODING GEN
EP2264184A1 (de) 2009-06-22 2010-12-22 Qiagen GmbH Verfahren zur Amplifikation von DNA unter Verwendung von Tetraethylenglykol, Kit-of-parts dafür und dessen Verwendung
US9212397B2 (en) 2009-06-23 2015-12-15 Gen-Probe Incorporated Compositions and methods for detecting nucleic acid from mollicutes
WO2011005598A1 (en) 2009-06-24 2011-01-13 University Of Southern California Compositions and methods for the rapid biosynthesis and in vivo screening of biologically relevant peptides
JP6073133B2 (ja) 2009-06-24 2017-02-01 クルナ・インコーポレーテッド 腫瘍壊死因子受容体２（ｔｎｆｒ２）に対する天然アンチセンス転写物の抑制によるｔｎｆｒ２関連疾患の治療
IN2012DN00715A (ko) 2009-06-24 2015-06-19 Health Corp Rambam
EP2446027A1 (en) 2009-06-25 2012-05-02 Danisco A/S Protein
KR101829073B1 (ko) 2009-06-26 2018-02-13 아이2 파마슈티컬스, 인크. 대리 경쇄의 발현
WO2010151705A2 (en) 2009-06-26 2010-12-29 Claremont Biosolutions Llc Capture and elution of bio-analytes via beads that are used to disrupt specimens
EP2446037B1 (en) 2009-06-26 2016-04-20 CuRNA, Inc. Treatment of down syndrome gene related diseases by inhibition of natural antisense transcript to a down syndrome gene
EP2789689B1 (en) 2009-06-29 2016-04-27 Luminex Corporation Chimeric primers with hairpin conformations and methods of using same
CA2766798A1 (en) 2009-06-30 2011-01-06 Abbott Laboratories Markers of xmrv infection and uses thereof
WO2011000107A1 (en) 2009-07-01 2011-01-06 Protiva Biotherapeutics, Inc. Novel lipid formulations for delivery of therapeutic agents to solid tumors
US9169512B2 (en) 2009-07-01 2015-10-27 Gen-Probe Incorporated Methods and compositions for nucleic acid amplification
SG176970A1 (en) 2009-07-02 2012-02-28 Verdezyne Inc Biological methods for preparing adipic acid
CN102625852A (zh) 2009-07-07 2012-08-01 南加利福尼亚大学 用于自身免疫疾病早期检测的生物标记
EP2272980A1 (en) 2009-07-09 2011-01-12 Bioesplora SRL Molecular probes for target nucleic acid detection and quantification
US9663778B2 (en) 2009-07-09 2017-05-30 OPKO Biologies Ltd. Long-acting coagulation factors and methods of producing same
WO2011006136A2 (en) * 2009-07-09 2011-01-13 Verdezyne, Inc. Engineered microorganisms with enhanced fermentation activity
WO2011004379A1 (en) 2009-07-10 2011-01-13 Tel Hashomer Medical Research Infrastructure And Services Ltd. Compositions and methods for treating cancer
EP2454372B1 (en) 2009-07-15 2018-10-03 Zhenglun Zhu Managing the treatment of inflammatory or autoimmune disorders using hom-1 expression
ES2605801T3 (es) 2009-07-15 2017-03-16 Portola Pharmaceuticals, Inc. Formulación de dosis unitaria de antídoto para inhibidores del factor Xa para su uso en la prevención de la hemorragia
WO2011008972A1 (en) 2009-07-17 2011-01-20 Ibis Biosciences, Inc. Systems for bioagent identification
WO2011006982A2 (en) 2009-07-17 2011-01-20 Rigshospitalet Inhibitors of complement activation
US8950604B2 (en) 2009-07-17 2015-02-10 Ibis Biosciences, Inc. Lift and mount apparatus
US8188335B2 (en) 2009-07-17 2012-05-29 Abbott Laboratories Δ9-elongase for production of polyunsaturated fatty acid-enriched oils
CN107090031A (zh) 2009-07-17 2017-08-25 生物蛋白有限公司 在生产宿主中同时整合抗体/蛋白的性能和表达的筛选和演化的方法
US8716464B2 (en) 2009-07-20 2014-05-06 Thomas W. Geisbert Compositions and methods for silencing Ebola virus gene expression
AU2010274581B2 (en) 2009-07-21 2014-05-01 Tel Hashomer Medical Research Infrastructure And Services Ltd. A method of diagnosing cancer
US8628924B2 (en) 2009-07-21 2014-01-14 Gen-Probe Incorporated Methods and compositions for quantitative amplification and detection over a wide dynamic range
WO2011011391A1 (en) 2009-07-22 2011-01-27 E.I. Dupont De Nemours And Company Sequences and their use for detection and characterization of e. coli o157:h7
WO2011009883A1 (en) 2009-07-23 2011-01-27 INSERM (Institut National de la Santé et de la Recherche Médicale) Selective cb2 receptor agonists for use in the prevention or treatment of alcoholic liver disease
US9409983B2 (en) 2009-07-23 2016-08-09 The Board Of Trustess Of The University Of Illinois Methods and compositions involving PBEF inhibitors for lung inflammation conditions and diseases
GB0913442D0 (en) 2009-07-31 2009-09-16 Univ Ramot Cell-targeting nanoparticles comprising polynucleotide agents and uses thereof
CN102762731B (zh) 2009-08-05 2018-06-22 库尔纳公司 通过抑制针对胰岛素基因(ins)的天然反义转录物来治疗胰岛素基因(ins)相关的疾病
US20110035843A1 (en) 2009-08-05 2011-02-10 Pioneer Hi-Bred International, Inc. Novel eto1 genes and use of same for reduced ethylene and improved stress tolerance in plants
WO2011017567A1 (en) 2009-08-05 2011-02-10 Life Technologies Corporation Methods for the analysis of proximity binding assay data
EP2461831B1 (en) 2009-08-06 2018-11-21 Novo Nordisk Health Care AG Growth hormones with prolonged in-vivo efficacy
CN104313027B (zh) 2009-08-11 2018-11-20 库尔纳公司 通过抑制脂连蛋白(adipoq)的天然反义转录物治疗脂连蛋白(adipoq)相关疾病
WO2011019393A2 (en) 2009-08-11 2011-02-17 President And Fellows Of Harvard College Class- and isoform-specific hdac inhibitors and uses thereof
EP2464754B1 (en) 2009-08-13 2014-03-12 Life Technologies Corporation Amelogenin snp on chromosome x
EP2467470A2 (en) 2009-08-17 2012-06-27 Technion Research & Development Foundation Ltd. Pericyte progenitor cells and methods of generating and using same
US8221753B2 (en) 2009-09-30 2012-07-17 Tracon Pharmaceuticals, Inc. Endoglin antibodies
US20110045053A1 (en) * 2009-08-18 2011-02-24 Shen Michael M Isolated population of luminal stem cells that give rise to prostate cancer and methods of using same
WO2011021102A2 (en) 2009-08-20 2011-02-24 Population Genetics Technologies Ltd Compositions and methods for intramolecular nucleic acid rearrangement
EP2467159A1 (en) 2009-08-20 2012-06-27 INSERM (Institut National de la Santé et de la Recherche Médicale) Vla-4 as a biomarker for prognosis and target for therapy in duchenne muscular dystrophy
KR101805213B1 (ko) 2009-08-21 2017-12-06 큐알엔에이, 인크. Ｃｈｉｐ에 대한 천연 안티센스 전사체의 억제에 의한 “ｈｓｐ70-상호작용 단백질(ｃｈｉｐ)의 ｃ-말단” 관련된 질환의 치료
AU2010284000A1 (en) * 2009-08-21 2012-03-22 Gilead Biologics, Inc. In vitro screening assays
WO2011022670A1 (en) * 2009-08-21 2011-02-24 Arresto Biosciences, Inc In vivo screening assays
AU2010286111A1 (en) 2009-08-21 2012-02-16 Beeologics Inc. Preventing and curing beneficial insect diseases via plant transcribed molecules
KR20120063488A (ko) * 2009-08-21 2012-06-15 길리아드 바이오로직스, 인크. 리실 옥시다제 및 ｌｏｘｌ２로부터의 촉매 도메인
US8481267B2 (en) 2009-08-21 2013-07-09 E. I. Du Pont De Nemours And Company Genetic fingerprinting and identification method
BR112012008084A2 (pt) * 2009-08-21 2019-09-24 Gilead Biologics Inc método terapêuticos e composições.
CA2771699C (en) 2009-08-21 2022-03-29 Smithkline Beecham (Cork) Limited Use of lapatinib for treating cancer
US20110059453A1 (en) * 2009-08-23 2011-03-10 Affymetrix, Inc. Poly(A) Tail Length Measurement by PCR
JP5813641B2 (ja) 2009-08-24 2015-11-17 アムニクス オペレーティング インコーポレイテッド 凝固第ｉｘ因子組成物ならびにそれを製造および使用する方法
WO2011031482A2 (en) 2009-08-25 2011-03-17 Curna, Inc. Treatment of 'iq motif containing gtpase activating protein' (iqgap) related diseases by inhibition of natural antisense transcript to iqgap
EP2470653A1 (en) 2009-08-26 2012-07-04 Research Development Foundation Methods for creating antibody libraries
US9642817B2 (en) 2009-08-27 2017-05-09 Technion Research & Development Foundation Limited Liposomal compositions and uses of same
US8222397B2 (en) * 2009-08-28 2012-07-17 Promega Corporation Methods of optimal purification of nucleic acids and kit for use in performing such methods
WO2011025905A1 (en) 2009-08-28 2011-03-03 Research Development Foundation Urocortin 2 analogs and uses thereof
EP2471927B1 (en) 2009-08-28 2015-12-23 Kirin Holdings Kabushiki Kaisha Protein having glycoalkaloid biosynthase activity, and gene encoding same
US8039613B2 (en) 2009-08-28 2011-10-18 Promega Corporation Methods of purifying a nucleic acid and formulation and kit for use in performing such methods
JP6057460B2 (ja) 2009-08-31 2017-01-11 ジェン−プローブ・インコーポレーテッド デングウイルスアッセイ
US8697435B2 (en) * 2009-08-31 2014-04-15 Mbio Diagnostics, Inc. Integrated sample preparation and analyte detection
WO2011022820A1 (en) 2009-08-31 2011-03-03 The Governors Of The University Of Alberta Binding-induced hairpin detection system
WO2011027966A2 (en) 2009-09-03 2011-03-10 Seegene, Inc. Td probe and its uses
US8785170B2 (en) 2009-09-04 2014-07-22 Codexis, Inc. Variant CBH2 cellulases and related polynucleotides
EP2294912A1 (en) 2009-09-04 2011-03-16 Wageningen Universiteit Method for increasing the level of zeaxanthin in a plant line, method for selecting a plant or part thereof, including a seed and tuber, and use thereof
US8889394B2 (en) * 2009-09-07 2014-11-18 Empire Technology Development Llc Multiple domain proteins
WO2011030332A2 (en) 2009-09-08 2011-03-17 Yeda Research And Development Co. Ltd. Methods for hematopoietic precursor mobilization
EP2475784A1 (en) 2009-09-08 2012-07-18 Ramot at Tel-Aviv University Ltd. Methods of diagnosing amyotrophic lateral sclerosis (als)
DE202010010523U1 (de) * 2009-09-09 2010-11-18 Helixis, Inc., Carlsbad Optisches System für Mehrfachreaktionen
WO2011030329A1 (en) 2009-09-10 2011-03-17 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Method of treating tumors
US10174368B2 (en) 2009-09-10 2019-01-08 Centrillion Technology Holdings Corporation Methods and systems for sequencing long nucleic acids
US9512481B2 (en) 2009-09-11 2016-12-06 The Regents Of The University Of Colorado, A Body Corporate Polymorphisms in the PDE3A gene
KR101759888B1 (ko) 2009-09-14 2017-07-20 신라젠(주) 종양 용해 백시니아 바이러스 병용 암 치료요법
AU2010295689B2 (en) 2009-09-17 2014-02-13 The Regents Of The University Of Michigan Recurrent gene fusions in prostate cancer
WO2011033506A2 (en) 2009-09-17 2011-03-24 Yeda Research And Development Co. Ltd. Isolated pon1 polypeptides, polynucleotides encoding same and uses thereof in treating or preventing organophosphate exposure associated damage
US8735124B2 (en) 2009-09-17 2014-05-27 Yeda Research And Development Co. Ltd. Isolated PON1 polypeptides, polynucleotides encoding same and uses thereof in treating or preventing organophosphate exposure associated damage
EP2478009B1 (en) 2009-09-17 2016-06-01 Ramot at Tel-Aviv University Ltd. Peptides for the treatment of oxidative stress related disorders
FR2950358B1 (fr) 2009-09-18 2015-09-11 Biomerieux Sa Dispositif d'amplification d'acides nucleiques simplifie et son procede de mise en oeuvre
US9932554B2 (en) 2009-09-18 2018-04-03 Phycoil Biotechnology International, Inc. Microalgae fermentation using controlled Illumination
US20110070590A1 (en) 2009-09-22 2011-03-24 Jan Rohozinski Primers and Methods for Determining RhD Zygosity
CA2775092A1 (en) 2009-09-23 2011-03-31 Protiva Biotherapeutics, Inc. Compositions and methods for silencing genes expressed in cancer
BR112012008381A2 (pt) 2009-09-24 2017-06-13 Inserm (Institut Nat De La Santé Et De La Rech Médicale) interação fkbp52-tau como novo alvo terapêutico para tratar os distúrbios neurológicos envolvendo disfunção da tau
CN102630250A (zh) * 2009-09-25 2012-08-08 基因诊断测试公司 用于检测与癌症和其他疾病相关的染色体异常的多重(+/-)链阵列和测试
CN102791861B (zh) 2009-09-25 2018-08-07 库尔纳公司 通过调节聚丝蛋白(flg)的表达和活性而治疗flg相关疾病
WO2011037802A2 (en) 2009-09-28 2011-03-31 Igor Kutyavin Methods and compositions for detection of nucleic acids based on stabilized oligonucleotide probe complexes
JP2013505739A (ja) 2009-09-29 2013-02-21 ビュータマックス・アドバンスド・バイオフューエルズ・エルエルシー 乳酸菌におけるアセト乳酸誘導生成物への改善されたフラックス
BR112012006939A2 (pt) 2009-09-29 2015-09-08 Butamax Tm Advanced Biofuels célula hospedeira de produção de levedura recombinante e método para a produção de um produto selecionado do grupo que consiste em 2,3-butanodiol, isobutanol, 2-butanol, 1-butanol, 2-butanona, valina, leucina, ácido lático, ácido málico, álcool, isoampilico e isoprenoides
DK2483415T3 (en) 2009-09-30 2015-02-09 Codexis Inc RECOMBINANT C1 B-glucosidase FOR MANUFACTURE OF sugars from cellulosic BIOMASS
EP3375791A1 (en) 2009-09-30 2018-09-19 Memorial Sloan Kettering Cancer Center Combination immunotherapy for the treatment of cancer
BR112012009381A2 (pt) 2009-10-02 2017-03-01 Syngenta Participations Ag "proteínas inseticidas"
US8962251B2 (en) * 2009-10-08 2015-02-24 Medical Service Consultation International, Llc Methods and compositions for identifying sulfur and iron modifying bacteria
WO2011044541A2 (en) * 2009-10-09 2011-04-14 Baylor Research Institute Identification of micrornas (mirnas) in fecal samples as biomarkers for gastroenterological cancers
WO2011042564A1 (en) 2009-10-09 2011-04-14 Universite De Strasbourg Labelled silica-based nanomaterial with enhanced properties and uses thereof
US8962584B2 (en) 2009-10-14 2015-02-24 Yissum Research Development Company Of The Hebrew University Of Jerusalem, Ltd. Compositions for controlling Varroa mites in bees
WO2011045796A1 (en) 2009-10-14 2011-04-21 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Compositions for controlling varroa mites in bees
EP2488668B1 (en) 2009-10-15 2023-07-26 Life Technologies Corporation Novel human single nucleotide polymorphisms
EP3225695A1 (en) 2009-10-15 2017-10-04 Ibis Biosciences, Inc. Multiple displacement amplification
UA109884C2 (uk) 2009-10-16 2015-10-26 Поліпептид, що має активність ферменту фосфатидилінозитол-специфічної фосфоліпази с, нуклеїнова кислота, що його кодує, та спосіб його виробництва і застосування
UA111708C2 (uk) 2009-10-16 2016-06-10 Бандж Ойлз, Інк. Спосіб рафінування олії
US8975019B2 (en) 2009-10-19 2015-03-10 University Of Massachusetts Deducing exon connectivity by RNA-templated DNA ligation/sequencing
WO2011049439A1 (en) 2009-10-19 2011-04-28 Universiteit Twente Method for selecting bone forming mesenchymal stem cells
WO2011048070A1 (en) 2009-10-20 2011-04-28 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment of disorders of glucose homeostasis
US9476060B2 (en) 2009-10-21 2016-10-25 Danziger Innovations Ltd. Generating genotypic variations in plant genomes by gamete infection
WO2011050096A2 (en) 2009-10-21 2011-04-28 Retinal Solutions Llc Methods and compositions for diagnosis and treatment of genetic and retinal disease
CA2775273A1 (en) 2009-10-22 2011-04-28 Biotools Biotechnological & Medical Laboratories, S.A. Composition, method and kit for detecting bacteria by means of sequencing
JP5938348B2 (ja) 2009-10-23 2016-06-22 ルミネックス コーポレーション 反応特異性の増加のための非標準塩基を含む増幅プライマー
TWI483736B (zh) 2009-10-23 2015-05-11 Millennium Pharm Inc 抗－ｇｃｃ抗體分子及其相關之組合物及方法
JP2013507987A (ja) * 2009-10-26 2013-03-07 アボット・ラボラトリーズ 非小細胞肺癌の予後を決定するための診断方法
CN102666849A (zh) 2009-10-26 2012-09-12 斯泰伦博斯大学 真菌纤维二糖水解酶2基因在酵母中的异源表达
WO2011056490A1 (en) 2009-10-26 2011-05-12 Abbott Laboratories Diagnostic methods for determining prognosis of non-small cell lung cancer
AU2010315400B2 (en) 2009-10-27 2016-07-21 Caris Mpi, Inc. Molecular profiling for personalized medicine
PL2496691T3 (pl) 2009-11-02 2017-09-29 University Of Washington Terapeutyczne kompozycje nukleazy i sposoby
WO2011055232A2 (en) 2009-11-04 2011-05-12 Population Genetics Technologies Ltd. Base-by-base mutation screening
US7972793B2 (en) 2009-11-04 2011-07-05 Suregene, Llc Methods and compositions for the treatment of psychotic disorders through the identification of the SULT4A1-1 haplotype
US20120282276A1 (en) 2009-11-05 2012-11-08 The Regents Of The University Of Michigan Biomarkers predictive of progression of fibrosis
WO2011057119A1 (en) 2009-11-06 2011-05-12 Enzymatics, Inc. Composition and method for synthesizing a deoxyribonucleotide chain using a double stranded nucleic acid complex with a thermostable polymerase
EP2501398A1 (en) 2009-11-06 2012-09-26 INSERM - Institut National de la Santé et de la Recherche Médicale Methods and pharmaceutical composition for the treatment of atherosclerosis
KR20110050327A (ko) 2009-11-07 2011-05-13 주식회사 씨젠 Ｔｈｄ 프라이머 타겟 검출
IL201999A (en) 2009-11-08 2017-10-31 Medical Res & Development Fund For Health Services Bnai Zion Medical Center The State Of Israel A knockout mouse of the 1 – mo gene, a gene associated with morbidly extreme obesity
GB0919690D0 (en) 2009-11-10 2009-12-23 Guy S And St Thomas S Nhs Foun compositions for immunising against staphylococcus aureus
WO2011058555A1 (en) 2009-11-12 2011-05-19 Yeda Research And Development Co. Ltd. A method of editing dna in a cell and constructs capable of same
EP3633025B1 (en) 2009-11-12 2022-09-14 Technion Research & Development Foundation Ltd. Culture media, cell cultures and methods of culturing pluripotent stem cells in an undifferentiated state
EP2498806B1 (en) 2009-11-12 2014-12-31 Ramot at Tel-Aviv University Ltd. Compositions comprising pedf and uses of same in the treatment and prevention of ovary-related syndromes
US20110117559A1 (en) * 2009-11-13 2011-05-19 Integrated Dna Technologies, Inc. Small rna detection assays
US8968740B2 (en) 2009-11-13 2015-03-03 Dana-Farber Cancer Institute, Inc. Compositions, kits, and methods for the diagnosis, prognosis, monitoring, treatment and modulation of post-transplant lymphoproliferative disorders and hypoxia associated angiogenesis disorders using galectin-1
EP2335717A1 (en) 2009-11-16 2011-06-22 Institut National De La Recherche Agronomique PAR-1 antagonists for use in the treatment or prevention of influenza virus type a infections
WO2011061736A1 (en) 2009-11-17 2011-05-26 Protalix Ltd. Alkaline alpha galactosidase for the treatment of fabry disease
GB0920089D0 (en) 2009-11-17 2009-12-30 Danisco Method
EP2905332B1 (en) 2009-11-19 2018-09-12 Solis BioDyne OÜ Compositions for increasing polypeptide stability and activity, and related methods
WO2011063198A2 (en) 2009-11-20 2011-05-26 St. Jude Children's Research Hospital Methods and compositions for modulating the activity of the interleukin-35 receptor complex
US20110154541A1 (en) * 2009-11-24 2011-06-23 Technion Research And Development Foundation Ltd. Bio-engineered photosystems
EP2504472A1 (en) 2009-11-24 2012-10-03 Collplant Ltd. Method of generating collagen fibers
US9216414B2 (en) 2009-11-25 2015-12-22 Gen9, Inc. Microfluidic devices and methods for gene synthesis
CN102639559B (zh) 2009-11-25 2015-04-29 诺沃—诺迪斯克有限公司 用于制备多肽的方法
WO2011066457A2 (en) 2009-11-25 2011-06-03 Codexis, Inc. Recombinant beta-glucosidase variants for production of soluble sugars from cellulosic biomass
WO2011066475A1 (en) 2009-11-26 2011-06-03 Quark Pharmaceuticals, Inc. Sirna compounds comprising terminal substitutions
IL288647B2 (en) 2009-11-30 2023-12-01 Pluri Biotech Ltd Adherent cells of placental origin and their use for the treatment of heart failure
EP2506861A1 (en) 2009-12-02 2012-10-10 Amgen Inc. Binding proteins that bind to human fgfr1c, human b-klotho and both human fgfr1c and human b-klotho
EP2507220B1 (en) * 2009-12-04 2016-10-05 Biotium Inc. Heterocycle-substituted xanthene dyes
US20110136190A1 (en) 2009-12-04 2011-06-09 E. I. Du Pont De Nemours And Company Recombinant bacteria for producing glycerol and glycerol-derived products from sucrose
WO2011067745A2 (en) 2009-12-06 2011-06-09 Rosetta Green Ltd. Compositions and methods for enhancing plants resistance to abiotic stress
CN102648295B (zh) 2009-12-07 2017-08-08 伊鲁米那股份有限公司 用于多重基因分型的多样品索引
WO2011071829A2 (en) 2009-12-07 2011-06-16 Mascoma Corporation Heterologous expression of urease in anaerobic, thermophilic hosts
US8501122B2 (en) 2009-12-08 2013-08-06 Affymetrix, Inc. Manufacturing and processing polymer arrays
US9121054B2 (en) * 2009-12-08 2015-09-01 Biohelix Corporation Detection of nucleic acid amplification products in the presence of an internal control sequence on an immunochromatographic strip
EP2510098B1 (en) 2009-12-09 2015-02-11 Quark Pharmaceuticals, Inc. Methods and compositions for treating diseases, disorders or injury of the cns
CN102762222B (zh) 2009-12-09 2015-11-25 丹尼斯科美国公司 包含蛋白酶变体的组合物和方法
EP2510088B1 (en) 2009-12-10 2016-10-05 Ottawa Hospital Research Institute Oncolytic rhabdovirus
US8614071B2 (en) 2009-12-11 2013-12-24 Roche Molecular Systems, Inc. Preferential amplification of mRNA over DNA using chemically modified primers
US8835358B2 (en) 2009-12-15 2014-09-16 Cellular Research, Inc. Digital counting of individual molecules by stochastic attachment of diverse labels
ES2661813T3 (es) 2009-12-16 2018-04-04 Curna, Inc. Tratamiento de enfermedades relacionadas con la peptidasa del factor de transcripción de membrana, sitio 1 (mbtps1) mediante inhibición del transcrito antisentido natural al gen mbtps1
US20110154525A1 (en) 2009-12-17 2011-06-23 Pioneer Hi-Bred International, Inc. Maize event DP-040416-8 and methods for detection thereof
US20110154524A1 (en) 2009-12-17 2011-06-23 Pioneer Hi-Bred International, Inc. Maize event DP-032316-8 and methods for detection thereof
EP2512226B1 (en) 2009-12-17 2019-05-01 Pioneer Hi-Bred International, Inc. Maize event dp-004114-3 and methods for detection thereof
US8431346B2 (en) * 2009-12-18 2013-04-30 Agrigenomics, Inc. Screening for arthrogryposis multiplex in bovines
AU2010336137B2 (en) 2009-12-21 2015-08-06 Seegene, Inc. TSG primer target detection
US20110151457A1 (en) 2009-12-22 2011-06-23 Elitech Holding B.V. Hypertheromostable endonuclease iv substrate probe
WO2011076897A1 (en) 2009-12-22 2011-06-30 Novozymes A/S Use of amylase variants at low temperature
EP2516680B1 (en) 2009-12-22 2016-04-06 Sequenom, Inc. Processes and kits for identifying aneuploidy
JP5934106B2 (ja) 2009-12-23 2016-06-15 カッパーアールエヌエー，インコーポレイテッド 肝細胞増殖因子（ｈｇｆ）に対する天然アンチセンス転写物の阻害によるｈｇｆ関連性疾患の治療
WO2011079283A1 (en) * 2009-12-23 2011-06-30 Bioalliance C.V. Anti-epcam antibodies that induce apoptosis of cancer cells and methods using same
CA2782375C (en) 2009-12-23 2023-10-31 Opko Curna, Llc Treatment of uncoupling protein 2 (ucp2) related diseases by inhibition of natural antisense transcript to ucp2
WO2011079273A2 (en) 2009-12-23 2011-06-30 Arca Biopharma, Inc. Methods and compositions for cardiovascular diseases and conditions
EP2517025B1 (en) 2009-12-23 2019-11-27 Bio-Rad Laboratories, Inc. Methods for reducing the exchange of molecules between droplets
US9493785B2 (en) 2009-12-28 2016-11-15 Evogene Ltd. Isolated polynucleotides and polypeptides and methods of using same for increasing plant yield, biomass, growth rate, vigor, oil content, abiotic stress tolerance of plants and nitrogen use efficiency
WO2011090690A1 (en) 2009-12-28 2011-07-28 Pioneer Hi-Bred International, Inc. Sorghum fertility restorer genotypes and methods of marker-assisted selection
EP2519634B1 (en) 2009-12-29 2016-06-01 CuRNA, Inc. TREATMENT OF TUMOR PROTEIN 63 (p63) RELATED DISEASES BY INHIBITION OF NATURAL ANTISENSE TRANSCRIPT TO p63
US8921334B2 (en) 2009-12-29 2014-12-30 Curna, Inc. Treatment of nuclear respiratory factor 1 (NRF1) related diseases by inhibition of natural antisense transcript to NRF1
EP3785712A1 (en) 2009-12-29 2021-03-03 Gamida-Cell Ltd. Methods for enhancing natural killer cell proliferation and activity
WO2011082325A2 (en) 2009-12-31 2011-07-07 Life Technologies Corporation Sequences of e.coli 055:h7 genome
WO2011082281A2 (en) 2009-12-31 2011-07-07 Curna, Inc. Treatment of insulin receptor substrate 2 (irs2) related diseases by inhibition of natural antisense transcript to irs2 and transcription factor e3 (tfe3)
KR101878501B1 (ko) 2010-01-04 2018-08-07 큐알엔에이, 인크. 인터페론 조절 인자 8 (ｉｒｆ8)에 대한 자연 안티센스 전사체의 저해에 의한 인터페론 조절 인자 8 (ｉｒｆ8) 관련된 질환의 치료
EP2521772A1 (en) 2010-01-04 2012-11-14 Novozymes A/S Alpha-amylases
KR101853509B1 (ko) 2010-01-06 2018-04-30 큐알엔에이, 인크. 췌장 발달 유전자에 대한 천연 안티센스 전사체의 억제에 의한 췌장 발달 유전자와 관련된 질환의 치료
WO2011084193A1 (en) 2010-01-07 2011-07-14 Quark Pharmaceuticals, Inc. Oligonucleotide compounds comprising non-nucleotide overhangs
US8735327B2 (en) 2010-01-07 2014-05-27 Jeansee, Llc Combinatorial DNA taggants and methods of preparation and use thereof
US9217144B2 (en) 2010-01-07 2015-12-22 Gen9, Inc. Assembly of high fidelity polynucleotides
WO2011085334A1 (en) 2010-01-11 2011-07-14 University Of Southern California Cd44 polymorphisms predict clinical outcome in patients with gastric cancer
ES2664866T3 (es) 2010-01-11 2018-04-23 Curna, Inc. Tratamiento de enfermedades relacionadas con la globulina fijadora de hormonas sexuales (shbg) mediante inhibición del transcrito antisentido natural a shbg
WO2011086497A2 (en) 2010-01-12 2011-07-21 Ahram Biosystems, Inc. Three-stage thermal convection apparatus and uses thereof
KR102032523B1 (ko) 2010-01-12 2019-10-15 아람 바이오시스템 주식회사 2단 열대류 장치 및 그 사용법
US20110173569A1 (en) 2010-01-13 2011-07-14 Rockmelt, Inc. Preview Functionality for Increased Browsing Speed
US9745589B2 (en) 2010-01-14 2017-08-29 Cornell University Methods for modulating skeletal remodeling and patterning by modulating SHN2 activity, SHN3 activity, or SHN2 and SHN3 activity in combination
WO2011088425A2 (en) 2010-01-15 2011-07-21 The Regents Of The University Of California Electro-autotrophic synthesis of higher alcohols
JP5828152B6 (ja) 2010-01-20 2018-09-19 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル 血管内皮細胞バリアの完全性の保存ための方法及び医薬的組成物
ES2543634T3 (es) 2010-01-22 2015-08-20 Novo Nordisk A/S Proceso para preparación de FGF-21 con grado de O-glicosilación bajo
JP2013520162A (ja) 2010-01-22 2013-06-06 デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド 代謝障害の同定、査定、予防および治療のための組成物、キットおよび方法
JP5980689B2 (ja) 2010-01-22 2016-08-31 ノヴォ・ノルディスク・ヘルス・ケア・アーゲー 安定な成長ホルモン化合物
SI2525834T1 (sl) 2010-01-22 2019-10-30 Novo Nordisk Healthcare Ag Rastni hormoni s podaljšano in vivo učinkovitostjo
JP2011147411A (ja) * 2010-01-25 2011-08-04 Seiko Epson Corp 核酸増幅方法および核酸増幅装置、ならびに核酸増幅用チップ
CN102782135A (zh) 2010-01-25 2012-11-14 库尔纳公司 通过抑制rna酶h1的天然反义转录物而治疗rna酶h1相关疾病
EP2528949A1 (en) 2010-01-27 2012-12-05 Yeda Research And Development Co. Ltd. Antibodies that inhibit metalloproteins
JP5791634B2 (ja) 2010-01-29 2015-10-07 マイクロニクス， インコーポレイテッド サンプル−回答型のマイクロ流体カートリッジ
AU2011209586B2 (en) 2010-02-01 2016-01-21 Cancer Research Technology Limited 1-(5-tert-butyl-2-phenyl-2h-pyrazol-3-yl)-3-[2-fluoro- 4-(1-methyl-2-oxo-2,3-dihydro-1h-imidazo [4,5-b]pyridin-7-yloxy)-phenyl] -urea and related compounds and their use in therapy
US8574832B2 (en) 2010-02-03 2013-11-05 Massachusetts Institute Of Technology Methods for preparing sequencing libraries
TWI518325B (zh) 2010-02-04 2016-01-21 自治醫科大學 對ａｌｋ抑制劑具有先抗性或後抗性癌症的識別、判斷和治療
JP6134142B2 (ja) 2010-02-04 2017-05-24 ギリアド バイオロジクス, インク.Gilead Biologics, Inc. リシルオキシダーゼ様２（ｌｏｘｌ２）に結合する抗体及びその使用方法
EP2353716A1 (en) 2010-02-05 2011-08-10 Ludwig-Maximilians-Universität München Method and apparatus for amplifying nucleic acid sequences
US20110202284A1 (en) * 2010-02-10 2011-08-18 Mcreynolds Cristopher Novel groups of biomarkers for diagnosing alzheimer's disease
EP3404087A1 (en) 2010-02-10 2018-11-21 Novozymes A/S Alpha-amylase variants with high stability in presence of a chelating agent
KR20120125357A (ko) 2010-02-10 2012-11-14 노파르티스 아게 근육 성장을 위한 방법 및 화합물
EP2357220A1 (en) 2010-02-10 2011-08-17 The Procter & Gamble Company Cleaning composition comprising amylase variants with high stability in the presence of a chelating agent
WO2011099006A2 (en) 2010-02-11 2011-08-18 Yeda Research And Development Co. Ltd. Enzymatic systems for carbon fixation and methods of generating same
AU2011215753B2 (en) * 2010-02-11 2015-09-03 Nanostring Technologies, Inc. Compositions and methods for the detection of small RNAs
ES2647611T3 (es) 2010-02-11 2017-12-22 Cj Cheiljedang Corporation Procedimiento para producir un acrilato de alquilo inferior y 2-buteno a partir de una biomasa genéticamente modificada de poli-3-hidroxibutirato
US9399797B2 (en) 2010-02-12 2016-07-26 Raindance Technologies, Inc. Digital analyte analysis
US9366632B2 (en) 2010-02-12 2016-06-14 Raindance Technologies, Inc. Digital analyte analysis
US20130078614A1 (en) 2010-02-12 2013-03-28 Yonsei University Wonju Industry-Academic Cooperation Foundation Probe for hpv genotype diagnosis and analysis method thereof
US10351905B2 (en) 2010-02-12 2019-07-16 Bio-Rad Laboratories, Inc. Digital analyte analysis
WO2011099015A1 (en) 2010-02-15 2011-08-18 Yeda Research And Development Co. Ltd. Bio-engineered multi-enzyme complexes comprising xylanases and uses thereof
US9181593B2 (en) 2010-02-17 2015-11-10 Gen-Probe Incorporated Compositions and methods to detect Atopobium vaginae nucleic acid
US9499860B2 (en) 2010-02-19 2016-11-22 The Ohio State University Primers and methods for nucleic acid amplification
US10030045B2 (en) 2010-02-19 2018-07-24 Ohio State Innovation Foundation Primers and methods for nucleic acid amplification
US8962586B2 (en) 2010-02-22 2015-02-24 Curna, Inc. Treatment of pyrroline-5-carboxylate reductase 1 (PYCR1) related diseases by inhibition of natural antisense transcript to PYCR1
US8298535B2 (en) 2010-02-24 2012-10-30 Rinat Neuroscience Corp. Anti-IL-7 receptor antibodies
CA2791058A1 (en) 2010-02-24 2011-09-01 Ben Gurion University Of The Negev Research And Development Authority Methods for inhibiting necrosis
RU2571930C2 (ru) 2010-02-25 2015-12-27 Дана-Фарбер Кэнсер Инститьют, Инк. Мутации braf, обеспечивающие резистентность к ингибиторам braf
WO2011106696A2 (en) 2010-02-26 2011-09-01 The Regents Of The University Of California Compositions and methods for the production of l-homoalanine
WO2011107939A1 (en) 2010-03-01 2011-09-09 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Methods of predicting efficacy of an anti-vegfa treatment for solid tumors
WO2011107887A2 (en) 2010-03-02 2011-09-09 Population Genetic Technologies Ltd. Methods for replicating polynucleotides with secondary structure
US20110275644A1 (en) 2010-03-03 2011-11-10 Buck Elizabeth A Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors
ES2631458T3 (es) 2010-03-04 2017-08-31 Interna Technologies B.V. Molécula de ARNmi definida por su fuente y sus usos terapéuticos en el cáncer asociado a la EMT
FR2957090A1 (fr) 2010-03-05 2011-09-09 Immunosearch Methode d'evaluation du potentiel irritant d'un compose test
FR2957089A1 (fr) 2010-03-05 2011-09-09 Immunosearch Methode d'evaluation du potentiel sensibilisant d'un compose test
CN102939380A (zh) 2010-03-05 2013-02-20 合成基因组股份有限公司 用于克隆和操作基因组的方法
FR2957088A1 (fr) 2010-03-05 2011-09-09 Immunosearch Methode d'evaluation du potentiel sensibilisant et/ou irritant d'un compose test
JP6148013B2 (ja) 2010-03-05 2017-06-14 リグショスピタレト 補体活性化のキメラ抑制分子
EP2545176B1 (en) 2010-03-08 2016-05-11 Yeda Research and Development Co. Ltd. Recombinant protein production in heterologous systems
KR20150067398A (ko) 2010-03-08 2015-06-17 다나-파버 캔서 인스티튜트 인크. 기준 차단 서열을 이용한 완전 ｃｏｌｄ－ｐｃｒ 풍부화
KR101982126B1 (ko) 2010-03-08 2019-05-27 몬산토 테크놀로지 엘엘씨 식물에서 유전자 조절을 위한 폴리뉴클레오타이드 분자
CN103038364A (zh) 2010-03-09 2013-04-10 达纳－法伯癌症研究所公司 诊断和治疗具有或发展对于第一种癌症治疗的抗性的患者中的癌症的方法
KR20120138241A (ko) 2010-03-11 2012-12-24 화이자 인코포레이티드 ｐＨ 의존성 항원 결합을 갖는 항체
US20120329089A1 (en) 2010-03-11 2012-12-27 Jacob Edrei Methods of generating hydrogen
EP2369325A1 (en) 2010-03-12 2011-09-28 Eppendorf Ag Array analysis for online detection
GB201004292D0 (en) * 2010-03-15 2010-04-28 Olink Ab Assay for localised detection of analytes
US20130045871A1 (en) 2010-03-18 2013-02-21 Cornell University Engineering correctly folded antibodies using inner membrane display of twin-arginine translocation intermediates
WO2011114251A1 (en) 2010-03-18 2011-09-22 Danisco A/S Foodstuff
US20130011831A1 (en) 2010-03-25 2013-01-10 Jing Luo Compositions And Methods For The Rapid Detection Of Legionella pneumophila
EP3153521B1 (en) 2010-03-26 2019-09-04 Trustees of Dartmouth College Vista regulatory t cell mediator protein, vista binding agents and use thereof
WO2011119934A2 (en) 2010-03-26 2011-09-29 Mayo Foundation For Medical Education And Research Methods and materials for detecting colorectal neoplasm
AU2011230496B2 (en) 2010-03-26 2015-09-17 Integrated Dna Technologies, Inc. Methods for enhancing nucleic acid hybridization
US20150231215A1 (en) 2012-06-22 2015-08-20 Randolph J. Noelle VISTA Antagonist and Methods of Use
US9506057B2 (en) 2010-03-26 2016-11-29 Integrated Dna Technologies, Inc. Modifications for antisense compounds
US20120108799A1 (en) 2010-09-07 2012-05-03 Integrated Dna Technologies, Inc. Modifications for Antisense Compounds
WO2011123246A2 (en) 2010-04-01 2011-10-06 Illumina, Inc. Solid-phase clonal amplification and related methods
ES2545188T3 (es) 2010-04-01 2015-09-09 Novartis Tiergesundheit Ag Marcador de resistencia a lactona macrocíclica para Dirofilaria immitis
KR101877065B1 (ko) 2010-04-02 2018-07-10 큐알엔에이, 인크. 집락 자극 인자 3 (ｃｓｆ3)에 대한 자연 안티센스 전사체의 저해에 의한 집락 자극 인자 3 (ｃｓｆ3) 관련된 질환의 치료
US20190300945A1 (en) 2010-04-05 2019-10-03 Prognosys Biosciences, Inc. Spatially Encoded Biological Assays
CA2794522C (en) 2010-04-05 2019-11-26 Prognosys Biosciences, Inc. Spatially encoded biological assays
US10787701B2 (en) 2010-04-05 2020-09-29 Prognosys Biosciences, Inc. Spatially encoded biological assays
JP2013523818A (ja) 2010-04-05 2013-06-17 ザ・ユニバーシティー・オブ・シカゴ 免疫反応のエンハンサーとしてのプロテインＡ（ＳｐＡ）抗体に関連する組成物および方法
CN103168118A (zh) 2010-04-06 2013-06-19 麻省理工学院 用减少数量的转录物测量进行的基因表达概况分析
CN102858979B (zh) 2010-04-09 2018-01-26 库尔纳公司 通过抑制成纤维细胞生长因子21(fgf21)的天然反义转录物而治疗fgf21相关疾病
EP2557913B1 (en) 2010-04-12 2016-08-03 Ben Gurion University Of The Negev Research And Development Authority Sulfotransferase of a red microalga and uses thereof
WO2011128897A1 (en) 2010-04-12 2011-10-20 Technion Research & Development Foundation Ltd. Populations of pancreatic progenitor cells and methods of isolating and using same
JP2013523182A (ja) 2010-04-15 2013-06-17 アボット・ラボラトリーズ アミロイドベータ結合タンパク質
JP6018044B2 (ja) 2010-04-15 2016-11-02 ダニスコ・ユーエス・インク プロテアーゼ変異体を含む組成物及び方法
WO2011127933A1 (en) 2010-04-16 2011-10-20 Nuevolution A/S Bi-functional complexes and methods for making and using such complexes
NZ701866A (en) 2010-04-16 2016-07-29 Zeus Scientific Inc Methods for measuring enzyme activity useful in determining cell viability in non-purified samples
WO2011130728A1 (en) 2010-04-17 2011-10-20 Bayer Healthcare Llc Synthetic metabolites of fluoro substituted omega-carboxyaryl diphenyl urea for the treatment and prevention diseases and conditions
RU2012148398A (ru) 2010-04-18 2014-05-27 Иеда Рисеч Энд Девелопмент Ко. Лтд. МОЛЕКУЛЫ И СПОСОБЫ ПРИМЕНЕНИЯ МОЛЕКУЛ ДЛЯ ЛЕЧЕНИЯ БОЛЕЗНЕЙ, АССОЦИИРОВАННЫХ С ErbB/ErbB ЛИГАНДАМИ
WO2011133512A1 (en) 2010-04-19 2011-10-27 Research Development Foundation Rtef-1 variants and uses thereof
US20110269735A1 (en) 2010-04-19 2011-11-03 Celera Corporation Genetic polymorphisms associated with statin response and cardiovascular diseases, methods of detection and uses thereof
BR112012026945B1 (pt) 2010-04-20 2021-05-25 Qiagen Gmbh método e aparelho para controlar a temperatura de um líquido
WO2011133811A2 (en) 2010-04-21 2011-10-27 Gen-Probe Incorporated Compositions, methods and kits to detect herpes simplex virus nucleic acid
US8841104B2 (en) 2010-04-21 2014-09-23 Nanomr, Inc. Methods for isolating a target analyte from a heterogeneous sample
US20110262989A1 (en) 2010-04-21 2011-10-27 Nanomr, Inc. Isolating a target analyte from a body fluid
US9476812B2 (en) 2010-04-21 2016-10-25 Dna Electronics, Inc. Methods for isolating a target analyte from a heterogeneous sample
ES2911185T3 (es) 2010-04-23 2022-05-18 Univ Florida Composiciones de rAAV-guanilato ciclasa y métodos para tratar la amaurosis congénita de Leber 1 (LCA1)
JP6066900B2 (ja) 2010-04-26 2017-01-25 エータイアー ファーマ， インコーポレイテッド システイニルｔＲＮＡ合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見
AU2011248614B2 (en) 2010-04-27 2017-02-16 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of isoleucyl tRNA synthetases
WO2011137192A1 (en) 2010-04-27 2011-11-03 The Regents Of The University Of California Production of 1,4-butanediol by recombinant microorganisms
EP2383572A1 (en) 2010-04-28 2011-11-02 Assistance Publique Hôpitaux de Marseille Cellular humoral activation test (CHAT)
CA2797271C (en) 2010-04-28 2021-05-25 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of alanyl trna synthetases
BR122021002337B1 (pt) 2010-04-28 2022-03-22 Evogene Ltd Método de aumento de produção, biomassa, taxa de crescimento, vigor, teor de óleo, produção de fibra qualidade de fibra, tolerância ao estresse abiótico e/ou eficiência de uso de nitrogênio de uma planta, e construto de ácido nucleico isolado
JP5454338B2 (ja) 2010-04-28 2014-03-26 株式会社島津製作所 液滴操作によるリアルタイム核酸増幅法
WO2011139854A2 (en) 2010-04-29 2011-11-10 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of asparaginyl trna synthetases
EP2563383B1 (en) 2010-04-29 2017-03-01 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of valyl trna synthetases
WO2011137369A1 (en) 2010-04-29 2011-11-03 The Regents Of The University Of California Production of gamma-aminobutyric acid by recombinant microorganisms
US8774494B2 (en) 2010-04-30 2014-07-08 Complete Genomics, Inc. Method and system for accurate alignment and registration of array for DNA sequencing
GB201007286D0 (en) 2010-04-30 2010-06-16 Astex Therapeutics Ltd New compounds
US9034321B2 (en) 2010-05-03 2015-05-19 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of phenylalanyl-alpha-tRNA synthetases
CN103140233B (zh) 2010-05-03 2017-04-05 Atyr 医药公司 与甲硫氨酰‑tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的发现
WO2011139387A1 (en) 2010-05-03 2011-11-10 Opko Curna, Llc Treatment of sirtuin (sirt) related diseases by inhibition of natural antisense transcript to a sirtuin (sirt)
CN102985103A (zh) 2010-05-04 2013-03-20 Atyr医药公司 与p38多-tRNA合成酶复合物相关的治疗、诊断和抗体组合物的创新发现
US9352000B2 (en) 2010-05-05 2016-05-31 Rappaport Family Institute For Research In The Medical Sciences Use of CCL1 in therapy
HUE045202T2 (hu) 2010-05-06 2019-12-30 Procter & Gamble Fogyasztási cikkek proteáz variánsokkal
JP6085249B2 (ja) 2010-05-06 2017-02-22 アダプティヴ バイオテクノロジーズ コーポレーション 複雑なアンプリコンの配列解析
US20120135912A1 (en) 2010-05-10 2012-05-31 Perseid Therapeutics Llc Polypeptide inhibitors of vla4
AU2011250904A1 (en) 2010-05-11 2012-11-08 Dow Agrosciences Llc spnK strains
WO2011141704A1 (en) 2010-05-12 2011-11-17 Protiva Biotherapeutics, Inc Novel cyclic cationic lipids and methods of use
CA2799307C (en) 2010-05-13 2019-07-02 Tel Hashomer Medical Research Infrastructure And Services Ltd. Isolated populations of adult renal cells and methods of isolating and using same
JP6396656B2 (ja) 2010-05-14 2018-09-26 エータイアー ファーマ， インコーポレイテッド フェニルアラニルβｔＲＮＡ合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見
TWI586356B (zh) 2010-05-14 2017-06-11 可娜公司 藉由抑制ｐａｒ４天然反股轉錄本治療ｐａｒ４相關疾病
US9309565B2 (en) 2010-05-14 2016-04-12 Life Technologies Corporation Karyotyping assay
US9163242B2 (en) 2010-05-14 2015-10-20 University Of Iowa Research Foundation HER2 nucleic acid aptamers
US20130217743A1 (en) 2010-05-14 2013-08-22 Cancer Prevention Pharmaceuticals, Inc. Cancer prevention and treatment methods based on dietary polyamine content
TW201144442A (en) 2010-05-17 2011-12-16 Dow Agrosciences Llc Production of DHA and other LC-PUFAs in plants
WO2011146725A1 (en) 2010-05-19 2011-11-24 Bayer Healthcare Llc Biomarkers for a multikinase inhibitor
KR101176139B1 (ko) 2010-05-20 2012-08-22 광주과학기술원 관절염 동물모델로서 연골 특이적 ＨＩＦ?２α 형질전환 마우스 및 이의 용도
KR101223660B1 (ko) 2010-05-20 2013-01-17 광주과학기술원 ＨＩＦ－２α 억제제를 유효성분으로 포함하는 관절염 예방 또는 치료용 약제학적 조성물
GB201008727D0 (en) 2010-05-25 2010-07-07 Glaxo Group Ltd Biomarkers
US8618253B2 (en) 2010-05-25 2013-12-31 Samsung Techwin Co., Ltd. Modified RNAse H and detection of nucleic acid amplification
RU2620978C2 (ru) 2010-05-26 2017-05-30 Курна, Инк. Лечение заболеваний, связанных с метионинсульфоксидредуктазой а (msra), путем ингибирования природного антисмыслового транскрипта гена msra
JPWO2011149032A1 (ja) 2010-05-26 2013-07-25 東ソー株式会社 生体試料固定装置
NO2576783T3 (ko) 2010-05-26 2018-04-28
CN103096913B (zh) 2010-05-27 2017-07-18 Atyr 医药公司 与谷氨酰胺酰‑tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现
SG10201504197SA (en) 2010-05-28 2015-06-29 Solazyme Inc Food Compositions Comprising Tailored Oils
EP2576577B1 (en) 2010-05-28 2015-03-18 Life Technologies Corporation Synthesis of 2', 3'-dideoxynucleosides for automated dna synthesis and pyrophosphorolysis activated polymerization
CN102884086B (zh) 2010-06-01 2015-11-25 加州理工学院 稳定的功能嵌合纤维二糖水解酶i类酶
AU2011261486B2 (en) 2010-06-01 2017-02-23 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of lysyl-tRNA synthetases
US8435737B2 (en) 2010-06-02 2013-05-07 Cal Poly Corporation Primers for the rapid and specific detection of propane-oxidizing and butane-oxidizing microorganisms and methods of using same
EP2575859B1 (en) 2010-06-03 2018-09-19 Ramot at Tel Aviv University, Ltd. Methods of treating diabetes and compositions capable of same
MX2020004501A (es) 2010-06-03 2021-11-09 Pharmacyclics Llc El uso de inhibidores de la tirosina quinasa de bruton (btk).
US9422598B2 (en) 2010-06-04 2016-08-23 Biomerieux Method and kit for the prognosis of colorectal cancer
JP2013529089A (ja) 2010-06-07 2013-07-18 エフ．ホフマン−ラ ロシュ アーゲー インターロイキン−６受容体を阻害するモノクローナル抗体による薬剤治療に対する応答を予測するための遺伝子発現マーカー
EP2576829A1 (en) 2010-06-07 2013-04-10 Osnat Ashur-Fabian Methods and kits for diagnosing conditions related to hypoxia
BR112012031295A2 (pt) 2010-06-07 2016-02-16 Yeda Res & Dev celulases modificadas com uma maior termoestabilidade
CA2799790A1 (en) 2010-06-09 2011-12-15 Dana-Farber Cancer Institute, Inc. A mek1 mutation conferring resistance to raf and mek inhibitors
WO2011156356A1 (en) 2010-06-09 2011-12-15 Zymogenetics, Inc. Dimeric vstm3 fusion proteins and related compositions and methods
WO2011156707A2 (en) 2010-06-11 2011-12-15 Life Technologies Corporation Alternative nucleotide flows in sequencing-by-synthesis methods
US9638632B2 (en) 2010-06-11 2017-05-02 Vanderbilt University Multiplexed interferometric detection system and method
EP2582794B2 (en) 2010-06-15 2024-04-24 FUJIFILM Cellular Dynamics, Inc. Generation of induced pluripotent stem cells from small volumes of peripheral blood
BR112012032126A2 (pt) 2010-06-16 2017-10-17 Futuragene Israel Ltd Empresa Isralense polinucleotídeo isolado, estrutura de ácido nucléico, sistema de estrutura de ácido nucléico, polipeptídeo isolado, planta, composição inseticida, e método para controlar ou exterminar um inseto
WO2011158243A2 (en) 2010-06-16 2011-12-22 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Method of diagnosing and treating cancer
US20120149080A1 (en) 2010-06-17 2012-06-14 Butamax(Tm) Advanced Biofuels Llc Yeast production culture for the production of butanol
WO2011157432A1 (en) 2010-06-18 2011-12-22 Roche Diagnostics Gmbh Dna polymerases with increased 3'-mismatch discrimination
JP5841136B2 (ja) 2010-06-18 2016-01-13 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 増大した３’末端ミスマッチ識別能を有するｄｎａポリメラーゼ
JP5926246B2 (ja) 2010-06-18 2016-05-25 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 増大した３’末端ミスマッチ識別能を有するｄｎａポリメラーゼ
CN103025869B (zh) 2010-06-18 2015-07-01 霍夫曼-拉罗奇有限公司 具有增强的3’-错配辨别力的dna聚合酶
JP5876479B2 (ja) 2010-06-18 2016-03-02 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 増大した３’末端ミスマッチ識別を有するｄｎａポリメラーゼ
EP2582802B1 (en) 2010-06-18 2016-01-13 Roche Diagnostics GmbH Dna polymerases with increased 3'-mismatch discrimination
CA2802304C (en) 2010-06-18 2016-01-12 F.Hoffman-La Roche Ag Dna polymerases with increased 3'-mismatch discrimination
US8871488B2 (en) 2010-06-18 2014-10-28 Butamax Advanced Biofuels Llc Recombinant host cells comprising phosphoketolases
WO2011163249A2 (en) 2010-06-21 2011-12-29 Life Technologies Corporation Compositions, kits, and methods for synthesis and/or detection of nucleic acids
IT1405994B1 (it) 2010-06-22 2014-02-06 Euroclone Spa Metodo ad elevata sensibilita' per rilevare un acido nucleico target in un campione
WO2011163401A2 (en) 2010-06-22 2011-12-29 Neogenix Oncology, Inc. Colon and pancreas cancer specific antigens and antibodies
ES2569220T3 (es) 2010-06-22 2016-05-09 F. Hoffmann-La Roche Ag Envase de suspensión para partículas de unión para el aislamiento de material biológico
JP6023705B2 (ja) 2010-06-23 2016-11-09 カッパーアールエヌエー，インコーポレイテッド ナトリウムチャネル、電位依存性、αサブユニット（ＳＣＮＡ）に対する天然アンチセンス転写物の阻害によるＳＣＮＡ関連疾患の治療
KR101553753B1 (ko) 2010-06-24 2015-09-16 쿠아크 파마수티칼스 인코퍼레이티드 Ｒｈｏａ에 대한 이중 가닥 ｒｎａ 및 그의 용도
EP2585593B1 (en) 2010-06-24 2017-03-01 Population Genetics Technologies Ltd. Methods for polynucleotide library production, immortalization and region of interest extraction
WO2011162612A1 (en) 2010-06-25 2011-12-29 Wageningen Universiteit Method for modulating the level of phosphorylation of starch in a plant line, method for selecting a plant or part thereof, including a seed and tuber, and use thereof
CA2804019A1 (en) 2010-06-28 2012-01-12 Codexis, Inc. Fatty alcohol forming acyl reductases (fars) and methods of use thereof
US8679822B2 (en) 2010-06-29 2014-03-25 E I Du Pont De Nemours And Company Xylose utilization in recombinant zymomonas
US8623623B2 (en) 2010-06-29 2014-01-07 E I Du Pont De Nemours And Company Xylose utilization in recombinant Zymomonas
CN102985566B (zh) 2010-06-30 2015-06-17 简.探针公司 使用分析物和过程控制信号的单次读取确定而鉴定含分析物的样品的方法和设备
JP6002128B2 (ja) 2010-07-02 2016-10-05 ザ・ユニバーシティ・オブ・シカゴＴｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｃｈｉｃａｇｏ プロテインＡ（ＳｐＡ）変種に関連する組成物および方法
NZ719520A (en) 2010-07-06 2017-07-28 Int Tech Bv Mirna and its diagnostic and therapeutic uses in diseases or conditions associated with melanoma, or in diseases or conditions associated with activated braf pathway
JP5951603B2 (ja) 2010-07-07 2016-07-13 ザ・リージェンツ・オブ・ザ・ユニバーシティ・オブ・ミシガンＴｈｅ Ｒｅｇｅｎｔｓ Ｏｆ Ｔｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｍｉｃｈｉｇａｎ 乳がんの診断および治療
GB201011513D0 (en) 2010-07-08 2010-08-25 Danisco Method
NZ605400A (en) 2010-07-09 2015-05-29 Biogen Idec Hemophilia Inc Chimeric clotting factors
JP6116479B2 (ja) 2010-07-12 2017-04-19 エータイアー ファーマ， インコーポレイテッド グリシルｔＲＮＡ合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見
US9234249B2 (en) 2010-07-12 2016-01-12 Gen-Probe Incorporated Compositions and assays to detect swine H1N1 influenza A virus, seasonal H1 influenza A virus and seasonal H3 influenza A virus nucleic acids
US9512188B2 (en) 2010-07-12 2016-12-06 The State Of Israel, Ministry Of Agriculture & Rural Development, Agricultural Research Organization (Aro) (Volcani Center) Isolated polynucleotides and methods and plants using same for regulating plant acidity
US8980860B2 (en) 2010-07-14 2015-03-17 Curna, Inc. Treatment of discs large homolog (DLG) related diseases by inhibition of natural antisense transcript to DLG
WO2012007951A1 (en) 2010-07-15 2012-01-19 Technion Research & Development Foundation Ltd. Isolated high affinity entities with t-cell receptor like specificity towards native complexes of mhc class ii and glutamic acid decarboxylase (gad) autoantigenic peptides
JP2013535963A (ja) 2010-07-15 2013-09-19 テクニオン リサーチ アンド ディベロップメント ファウンデーション リミテッド Ｍｈｃクラスｉｉと糖尿病関連自己抗原性ペプチドとの天然型複合体に対するｔ細胞受容体様特異性を有する単離された高親和性実体
EP2593554A2 (en) 2010-07-15 2013-05-22 Technion Research And Development Foundation Ltd. Nucleic acid construct for increasing abiotic stress tolerance in plants
GB201011971D0 (en) 2010-07-15 2010-09-01 Olink Ab Methods and product
SG10201902596TA (en) 2010-07-16 2019-04-29 Bioatla Llc Novel methods of protein evolution
MX351242B (es) 2010-07-16 2017-10-05 Stichting Vu Vumc Star Un metodo para analizar una muestra de sangre de un sujeto por la presencia de un marcador de enfermedad.
US9624469B2 (en) 2010-07-22 2017-04-18 Cellect Biotherapeutics Ltd. Regulatory immune cells with enhanced targeted cell death effect
WO2012010516A1 (en) 2010-07-22 2012-01-26 Novo Nordisk Health Care Ag Growth hormone conjugates
AU2011280936A1 (en) 2010-07-23 2013-02-28 President And Fellows Of Harvard College Methods of detecting prenatal or pregnancy-related diseases or conditions
EP2749887A3 (en) 2010-07-23 2014-10-01 Beckman Coulter, Inc. System Or Method Of Including Analytical Units
WO2012012725A2 (en) 2010-07-23 2012-01-26 President And Fellows Of Harvard College Methods of detecting diseases or conditions using phagocytic cells
US20130266940A1 (en) 2010-07-23 2013-10-10 President And Fellows Of Harvard College Methods of Detecting Kidney-Associated Diseases or Conditions
AU2011281012A1 (en) 2010-07-23 2013-02-28 President And Fellows Of Harvard College Methods of detecting cardiovascular diseases or conditions
EP2598660B1 (en) 2010-07-26 2017-03-15 Biomatrica, INC. Compositions for stabilizing dna, rna and proteins in blood and other biological samples during shipping and storage at ambient temperatures
EP2598661B1 (en) 2010-07-26 2017-09-27 Biomatrica, INC. Compositions for stabilizing dna, rna and proteins in saliva and other biological samples during shipping and storage at ambient temperatures
WO2012014205A1 (en) 2010-07-27 2012-02-02 Technion Research & Development Foundation Ltd. Isolated mesenchymal progenitor cells and extracellular matrix produced thereby
JP2013535966A (ja) 2010-07-27 2013-09-19 テクニオン リサーチ アンド ディベロップメント ファウンデーション リミテッド 引き抜かれた毛包由来のケラチン生成細胞から誘導多能性幹細胞を生成させる方法
US20130130311A1 (en) 2010-07-27 2013-05-23 Yeda Research And Development Co., Ltd. Methods and systems for assessing clonality of cell cultures
CN103069007A (zh) 2010-07-29 2013-04-24 霍夫曼-拉罗奇有限公司 微生物核酸的定性和定量检测
EP2759604B1 (en) 2010-07-29 2016-09-21 F. Hoffmann-La Roche AG Control nucleic acids for multiple parameters
CA2802550C (en) 2010-07-29 2019-01-15 F. Hoffmann-La Roche Ag Generic pcr
CN103025891A (zh) 2010-07-29 2013-04-03 霍夫曼-拉罗奇有限公司 通用样品制备
US9175354B2 (en) 2010-08-03 2015-11-03 Life Technologies Corporation Detection of Salmonella enterica subspecies enterica serovar Enteritidis in food and environmental samples, methods and compositions therefor
EP2600885A2 (en) 2010-08-04 2013-06-12 Ramot at Tel Aviv University, Ltd. Methods of treating autoimmune diseases of the central nervous system (cns) and neurodegenerative diseases
CA2806858C (en) 2010-08-04 2021-06-15 Cellular Dynamics International, Inc. Reprogramming immortalized b cells
US20120034603A1 (en) 2010-08-06 2012-02-09 Tandem Diagnostics, Inc. Ligation-based detection of genetic variants
EP2601307A4 (en) 2010-08-06 2014-01-01 Capitalbio Corp MICROARRAY TEST WITH PARTICLES FOR THE ANALYSIS OF MOLECULAR INTERACTIONS
EP2418286A1 (en) 2010-08-10 2012-02-15 QIAGEN GmbH Improved method for isothermal amplification of nucleic acids
CA2807685C (en) 2010-08-13 2020-10-06 Aileron Therapeutics, Inc. P53 derived peptidomimetic macrocycle
EP2603524A1 (en) 2010-08-14 2013-06-19 AbbVie Inc. Amyloid-beta binding proteins
CN111426533A (zh) 2010-08-18 2020-07-17 压力生物科技公司 流通式高静压的微流样本的预处理设备及其相关方法
US20120058461A1 (en) 2010-08-18 2012-03-08 Abbott Laboratories Molecular detection of xmrv infection
CN106198656B (zh) 2010-08-18 2018-12-11 生命科技股份有限公司 用于电化学检测装置的微孔的化学涂层
WO2012024518A1 (en) 2010-08-18 2012-02-23 Abbott Laboratories Molecular detection of xmrv infection
CN103154263A (zh) 2010-08-19 2013-06-12 诺维信公司 诱导的孢子形成筛选方法
SG187830A1 (en) 2010-08-22 2013-03-28 Univ Ramot Induced pluripotent stem cells derived from human pancreatic beta cells
WO2012027611A2 (en) 2010-08-25 2012-03-01 Atyr Pharma, Inc. INNOVATIVE DISCOVERY OF THERAPEUTIC, DIAGNOSTIC, AND ANTIBODY COMPOSITIONS RELATED TO PROTEIN FRAGMENTS OF TYROSYL-tRNA SYNTHETASES
AR082530A1 (es) 2010-08-30 2012-12-12 Evogene Ltd Polinucleotidos y polipeptidos aislados, y metodos para utilizarlos para aumentar la eficacia en el uso de nitrogeno, rendimiento, tasa de crecimiento, vigor, biomasa, contenido de aceite y/o tolerancia al estres abiotico
EP2611932A2 (en) 2010-08-30 2013-07-10 Gen-Probe Incorporated Compositions, methods and reaction mixtures for the detection of xenotropic murine leukemia virus-related virus
JP5794770B2 (ja) 2010-08-31 2015-10-14 キリンホールディングス株式会社 グリコアルカロイド生合成酵素活性を有するタンパク質とそれをコードする遺伝子
CA3201524A1 (en) 2010-08-31 2012-03-08 Theraclone Sciences, Inc. Human immunodeficiency virus (hiv)-neutralizing antibodies
KR101907434B1 (ko) 2010-09-03 2018-10-12 발네바 오스트리아 게엠베하 C. 디피실의 a 독소 및 b 독소 단백질의 분리된 폴리펩타이드 및 이의 용도
EP2426222A1 (en) 2010-09-07 2012-03-07 F. Hoffmann-La Roche AG Generic buffer for amplification
WO2012032519A2 (en) 2010-09-07 2012-03-15 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Methods of diagnosing parkinson's disease
WO2012032510A1 (en) 2010-09-07 2012-03-15 Yeda Research And Development Co. Ltd. Primers for amplifying dna and methods of selecting same
EP3572501A1 (en) 2010-09-07 2019-11-27 Technion Research & Development Foundation Limited Novel methods and culture media for culturing pluripotent stem cells
EP2614138B1 (en) 2010-09-07 2017-08-30 Butamax (TM) Advanced Biofuels LLC Integration of a polynucleotide encoding a polypeptide that catalyzes pyruvate to acetolactate conversion
BR112013005711A2 (pt) 2010-09-08 2017-06-13 Univ Texas método para tratar um tumor, mutante, molécula de ácido nucleico isolada, construção de expressão, composição, e, método para administrar uma terapia
JP2013540731A (ja) 2010-09-08 2013-11-07 イェダ リサーチ アンド デベロップメント カンパニー リミテッド 安定かつ長期間の生着のための免疫抑制薬物組合せ
SG188473A1 (en) 2010-09-08 2013-05-31 Yeda Res & Dev Use of anti third party central memory t cells for anti-leukemia/lymphoma treatment
WO2012034067A1 (en) 2010-09-09 2012-03-15 The University Of Chicago Methods and compositions involving protective staphylococcal antigens
EP2616539A1 (en) 2010-09-15 2013-07-24 Ramot at Tel-Aviv University Ltd. Methods of expanding and redifferentiating islet beta cells
CA2811333C (en) 2010-09-16 2020-05-12 Gen-Probe Incorporated Capture probes immobilizable via l-nucleotide tail
WO2012038956A1 (en) 2010-09-20 2012-03-29 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Method of treating neurodegenerative diseases
US9090946B2 (en) 2010-09-21 2015-07-28 Life Technologies Corporation SE33 mutations impacting genotype concordance
CN110878345A (zh) 2010-09-21 2020-03-13 安捷伦科技有限公司 通过分子计数提高等位基因调用的置信度
WO2012038049A2 (en) 2010-09-22 2012-03-29 Roche Diagnostics Gmbh Amplification of distant nucleic acid targets using engineered primers
WO2012040619A2 (en) 2010-09-24 2012-03-29 Massachusetts Eye And Ear Infirmary Methods and compositions for prognosing and/or detecting age-related macular degeneration
KR20130113447A (ko) 2010-09-24 2013-10-15 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 고정된 프라이머들을 이용하여 표적 dna의 직접적인 캡쳐, 증폭 및 서열화
DK3399035T3 (da) 2010-09-27 2021-05-17 Vipergen Aps Fremgangsmåde til fremstilling af et beriget bibliotek
EP2621511A1 (en) 2010-09-28 2013-08-07 INSERM - Institut National de la Santé et de la Recherche Médicale Methods and pharmaceutical compositions for the treatment of bone density related diseases
US9110079B2 (en) 2010-09-29 2015-08-18 Biomerieux Method and kit for establishing an in vitro prognosis on a patient exhibiting SIRS
WO2012045012A2 (en) 2010-09-30 2012-04-05 Raindance Technologies, Inc. Sandwich assays in droplets
JP2013541951A (ja) 2010-10-01 2013-11-21 アメリカ合衆国 ｐ５３アイソフォームによる幹細胞機能の操作
GB2497495B (en) 2010-10-04 2018-06-06 Gen Probe Prodesse Inc Compositions, methods and kits to detect adenovirus nucleic acids
US8993533B2 (en) 2010-10-06 2015-03-31 Curna, Inc. Treatment of sialidase 4 (NEU4) related diseases by inhibition of natural antisense transcript to NEU4
EP3561073A1 (en) 2010-10-08 2019-10-30 President and Fellows of Harvard College High-throughput immune sequencing
US9902950B2 (en) 2010-10-08 2018-02-27 President And Fellows Of Harvard College High-throughput single cell barcoding
US10479969B2 (en) 2010-10-11 2019-11-19 Phycoil Biotechnology International. Inc. Utilization of wastewater for microalgal cultivation
WO2012051301A1 (en) 2010-10-12 2012-04-19 President And Fellows Of Harvard College Methods for identifying modulators of triglyceride metabolism, for modulating triglyceride metabolism and for identifying subjects at risk for abnormal triglyceride metabolism
US8725422B2 (en) 2010-10-13 2014-05-13 Complete Genomics, Inc. Methods for estimating genome-wide copy number variations
WO2012049279A1 (en) 2010-10-14 2012-04-19 Universitaet Des Saarlandes MEANS AND METHODS APPLYING SINGLE NUCLEOTIDE PRIMER EXTENSION WITH ION PAIR-, REVERSED-PHASE HPLC (SIRPH) FOR THE DIAGNOSIS OF SNPs
KR101852646B1 (ko) 2010-10-15 2018-04-26 유니바사루 바이오 리사치 가부시키가이샤 다기능 분주 유닛을 이용한 핵산 자동 처리장치 및 그 방법
WO2012051567A2 (en) 2010-10-15 2012-04-19 The Trustees Of Columbia University In The City Of New York Obesity-related genes and their proteins and uses thereof
US10669569B2 (en) 2010-10-15 2020-06-02 Navinci Diagnostics Ab Dynamic range methods
EP3075396A1 (en) 2010-10-17 2016-10-05 Yeda Research and Development Co. Ltd. Methods and compositions for the treatment of insulin-associated medical conditions
WO2012052878A1 (en) 2010-10-19 2012-04-26 Vascular Biogenics Ltd. Isolated polynucleotides and nucleic acid constructs for directing expression of a gene-of-interest in cells
US8409807B2 (en) 2010-10-22 2013-04-02 T2 Biosystems, Inc. NMR systems and methods for the rapid detection of analytes
US8563298B2 (en) 2010-10-22 2013-10-22 T2 Biosystems, Inc. NMR systems and methods for the rapid detection of analytes
EP2630517B1 (en) 2010-10-22 2016-03-16 T2 Biosystems, Inc. Nmr systems and methods for the rapid detection of analytes
CA2815212A1 (en) 2010-10-22 2012-04-26 Curna, Inc. Treatment of alpha-l-iduronidase (idua) related diseases by inhibition of natural antisense transcript to idua
WO2012058303A2 (en) 2010-10-26 2012-05-03 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services, Centers For Disease Control And Prevention Rapid salmonella serotyping assay
US9115408B2 (en) 2010-10-26 2015-08-25 The United States Of America As Represented By The Secretary, Department Of Health And Human Services, Centers For Disease Control And Prevention Rapid Salmonella serotyping assay
CN103443271A (zh) 2010-10-27 2013-12-11 丹尼斯科美国公司 用于增加异戊二烯产量的异戊二烯合酶变体
WO2012058072A1 (en) 2010-10-27 2012-05-03 Harrisvaccines, Inc Method of rapidly producing vaccines for animals
US9310375B2 (en) 2010-10-27 2016-04-12 Capitalbio Corporation Luminophore-labeled molecules coupled with particles for microarray-based assays
WO2012056452A2 (en) 2010-10-27 2012-05-03 Nanocyte (Israel) Ltd. Pharmaceutical compositions and delivery devices comprising stinging cells or capsules
WO2012056455A1 (en) 2010-10-28 2012-05-03 Yeda Research And Development Co. Ltd. Methods of generating antibodies to metalloenzymes
EP2632494A4 (en) 2010-10-28 2016-04-20 Univ Yale Inc METHOD AND COMPOSITIONS FOR THE STUDY AND TREATMENT OF CANCER
US20130295571A1 (en) 2010-10-29 2013-11-07 Institut National De La Santee Et De La Recherche Medicale ( Inserm) Marker of breast tumors from the luminal-b subtype
WO2012061225A2 (en) 2010-11-01 2012-05-10 Becton, Dickinson And Company Gardnerella vaginalis assay
EP3388532B1 (en) 2010-11-01 2021-03-10 Gen-Probe Incorporated Integrated capture and amplification of target nucleic acid for sequencing
US20120108651A1 (en) 2010-11-02 2012-05-03 Leiden University Medical Center (LUMC) Acting on Behalf of Academic Hospital Leiden (AZL) Genetic polymorphisms associated with venous thrombosis and statin response, methods of detection and uses thereof
JP5948337B2 (ja) 2010-11-02 2016-07-06 ザ トラスティース オブ コロンビア ユニバーシティ インザ シティ オブ ニューヨーク 脱毛症の治療方法
HUE028981T2 (en) 2010-11-02 2017-02-28 Codexis Inc Preparations and methods for preparing fermentable sugars
EP2447721B1 (en) 2010-11-02 2017-03-15 F. Hoffmann-La Roche AG Instrument and method for automatically heat-sealing a microplate
DK2635671T3 (en) 2010-11-02 2016-10-24 Codexis Inc Improved fungi strains
US9284566B2 (en) 2010-11-03 2016-03-15 The Regents Of The University Of California Biofuel and chemical production by recombinant microorganisms via fermentation of proteinaceous biomass
US9410132B2 (en) 2010-11-04 2016-08-09 Ben-Gurion University Of The Negev Research And Development Authority Acyl-CoA: diacylglycerol acyltransferase 1-like gene (PtDGAT1) and uses thereof
WO2012064975A1 (en) 2010-11-12 2012-05-18 Gen9, Inc. Protein arrays and methods of using and making the same
CA3132011A1 (en) 2010-11-12 2012-06-14 Gen9, Inc. Methods and devices for nucleic acids synthesis
AR083885A1 (es) 2010-11-15 2013-03-27 Univ Ramot Analogos de dipeptidos para el tratamiento de afecciones asociadas con la formacion de fibrillas amiloides
CN103561751A (zh) 2010-11-15 2014-02-05 李昭男 由人类滋养层干细胞生成神经干细胞
CN103298954A (zh) 2010-11-15 2013-09-11 生命技术公司 用于多重扩增短串联重复基因座的方法和试剂盒
EP2641201B1 (en) 2010-11-16 2018-12-26 Life Technologies Corporation Systems and methods for the analysis of proximity binding assay data
WO2012066495A2 (en) 2010-11-17 2012-05-24 Ben Gurion University Of The Negev Research And Development Authority T-cell therapy to neurodegenerative diseases
US10000752B2 (en) 2010-11-18 2018-06-19 Curna, Inc. Antagonat compositions and methods of use
AU2011329753B2 (en) 2010-11-19 2015-07-23 The Regents Of The University Of Michigan ncRNA and uses thereof
US8945556B2 (en) 2010-11-19 2015-02-03 The Regents Of The University Of Michigan RAF gene fusions
KR102010598B1 (ko) 2010-11-23 2019-08-13 큐알엔에이, 인크. Nanog에 대한 자연 안티센스 전사체의 저해에 의한 nanog 관련된 질환의 치료
CA2818918A1 (en) 2010-11-24 2012-05-31 Pioneer Hi-Bred International, Inc. Brassica gat event dp-061061-7 and compositions and methods for the identification and/or detection thereof
CA2810180C (en) 2010-11-24 2015-07-28 Pioneer Hi-Bred International, Inc. Brassica gat event dp-073496-4 and compositions and methods for the identification and/or detection thereof
EP3081651A1 (en) 2010-11-24 2016-10-19 Yale University Compositions and methods for diagnosing and treating diseases and disorders associated with d-dt
EP2643454A4 (en) 2010-11-24 2014-05-21 Hong Gao EXPANSION OF HEMATOPOETIC STEM CELLS
GB201020179D0 (en) 2010-11-29 2011-01-12 Astex Therapeutics Ltd New compounds
US20130324436A1 (en) 2010-11-30 2013-12-05 Diagon Kft Procedure for nucleic acid-based diagnostic determination of bacterial germ counts and kit for this purpose
US9574171B2 (en) 2010-12-02 2017-02-21 Technion Research & Development Foundation Ltd. Methods of generating corneal cells and cell populations comprising same
WO2012075231A1 (en) 2010-12-03 2012-06-07 Brandeis University Methods and kits for detecting nucleic acid mutants in wild-type populations
JP6111200B2 (ja) 2010-12-03 2017-04-05 ダウ アグロサイエンシィズ エルエルシー 除草剤耐性イベント８２６４．４４．０６．１のスタック、関連するトランスジェニックダイズ系統、およびその検出
US8129170B1 (en) 2010-12-06 2012-03-06 E.I. Du Pont De Nemours And Company Recombinant bacteria having the ability to metabolize sucrose
US20120183960A1 (en) 2010-12-07 2012-07-19 Enterologics, Inc. Method for identifying e. coli m-17
JP6126381B2 (ja) 2010-12-10 2017-05-10 国立大学法人東京工業大学 標的核酸の検出方法及びキット
GB201020982D0 (en) 2010-12-10 2011-01-26 Stiftung Offentlichen Rechts Polymorphism
EP2652152A4 (en) 2010-12-13 2014-06-25 Life Technologies Corp POLYMERIZATION OF NUCLEIC ACIDS BY ACTIVATION BY POLYPHOSPHOROLYSIS REACTIONS (APP)
TWI667347B (zh) 2010-12-15 2019-08-01 瑞士商先正達合夥公司 大豆品種ｓｙｈｔ０ｈ２及偵測其之組合物及方法
EP2465945A1 (en) 2010-12-17 2012-06-20 F. Hoffmann-La Roche AG Generic matrix for control nucleic acids
WO2012085165A1 (en) 2010-12-21 2012-06-28 Recopharma Ab Tear substitutes
CN103269787B9 (zh) 2010-12-21 2016-07-20 株式会社岛津制作所 用于在管内操作对象成分的器件和方法
BR122021002251B1 (pt) 2010-12-22 2021-09-14 Evogene Ltd Método para aumentar a tolerância ao estresse abiótico, rendimento, biomassa, taxa de crescimento, vigor, conteúdo de óleo, rendimento de fibras, qualidade de fibras e/ou eficiência de utilização de nitrogênio de uma planta, e, construção de ácido nucleico isolado
SG191235A1 (en) 2010-12-22 2013-07-31 Danisco Us Inc Compositions and methods for improved isoprene production using two types of ispg enzymes
AU2011349148C1 (en) 2010-12-22 2017-08-24 Pioneer Hi-Bred International, Inc. QTLs associated with and methods for identifying whole plant field resistance to Sclerotinia
US9163281B2 (en) 2010-12-23 2015-10-20 Good Start Genetics, Inc. Methods for maintaining the integrity and identification of a nucleic acid template in a multiplex sequencing reaction
AR084358A1 (es) 2010-12-27 2013-05-08 Lilly Co Eli Composiciones y metodos para identificar y diferenciar componentes virales de vacunas multivalentes de la “fiebre de embarque” (complejo de enfermedad respiratoria bovina (brdc))
RU2595873C2 (ru) 2010-12-27 2016-08-27 Эли Лилли Энд Компани Вакцинные композиции, содержащие вирус бычьей вирусной диареи 1в типа, и способы их получения и применения
AU2011350620B2 (en) 2010-12-28 2017-03-02 Kamedis Ltd. Plant extracts for the treatment and prevention of infections
WO2012118555A1 (en) 2010-12-29 2012-09-07 Life Technologies Corporation Time-warped background signal for sequencing-by-synthesis operations
US20120171684A1 (en) 2010-12-29 2012-07-05 Life Technologies Corporation Ddao compounds as fluorescent reference standards
US10146906B2 (en) 2010-12-30 2018-12-04 Life Technologies Corporation Models for analyzing data from sequencing-by-synthesis operations
US10241075B2 (en) 2010-12-30 2019-03-26 Life Technologies Corporation Methods, systems, and computer readable media for nucleic acid sequencing
BR112013015595A2 (pt) 2010-12-30 2017-06-20 Pioneer Hi Bred Int método de identificação de uma primeira planta de feijão soja ou germoplasma que exibe resistência aprimorada a um ou mais biotipos de afídeo de feijão soja, polinucleotídeo isolado, kit para detectar ou selecionar pelo menos uma planta de feijão soja com resistência a afídeo aprimorada
US9683054B2 (en) 2010-12-31 2017-06-20 BioAlta, LLC Express humanization of antibodies
US9919047B2 (en) 2011-01-04 2018-03-20 Sillajen, Inc. Generation of antibodies to tumor antigens and generation of tumor specific complement dependent cytotoxicity by administration of oncolytic vaccinia virus
EP2474617A1 (en) 2011-01-11 2012-07-11 InteRNA Technologies BV Mir for treating neo-angiogenesis
EP3733870A3 (en) 2011-01-14 2021-01-27 Life Technologies Corporation Methods for identification and quantification of mirnas
US9315787B2 (en) 2011-01-14 2016-04-19 Kapa Biosystems, Inc. Modified DNA polymerases for improved amplification
WO2012099896A2 (en) 2011-01-17 2012-07-26 Life Technologies Corporation Workflow for detection of ligands using nucleic acids
WO2012099871A1 (en) 2011-01-17 2012-07-26 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Modulation of lrch4 activity and therapeutic application thereof
LT3272861T (lt) 2011-01-20 2020-03-25 Protalix Ltd. Alfa-galaktozidazės kompozicijos
US10131947B2 (en) 2011-01-25 2018-11-20 Ariosa Diagnostics, Inc. Noninvasive detection of fetal aneuploidy in egg donor pregnancies
US20120190021A1 (en) 2011-01-25 2012-07-26 Aria Diagnostics, Inc. Detection of genetic abnormalities
EP2668299B1 (en) 2011-01-26 2018-03-07 The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services Selective detection of haemophilus influenzae
GB201101621D0 (en) 2011-01-31 2011-03-16 Olink Ab Method and product
US20130316358A1 (en) 2011-01-31 2013-11-28 Yeda Research And Development Co. Ltd. Methods of diagnosing disease using overlap extension pcr
CA2826696C (en) 2011-02-02 2019-12-03 Exact Sciences Corporation Digital sequence analysis of dna methylation
CN105969773A (zh) 2011-02-03 2016-09-28 米尔纳医疗股份有限公司 Mir-124的合成模拟物
BR112013019853A2 (pt) 2011-02-03 2017-03-21 Mirna Therapeutics Inc miméticos sintéticos de mir-34
US8877212B2 (en) 2011-02-07 2014-11-04 Trudeau Institute Use of an IL12 receptor-beta 1 splice variant to diagnose active tuberculosis
WO2012108864A1 (en) 2011-02-08 2012-08-16 Illumina, Inc. Selective enrichment of nucleic acids
EP2673358B1 (en) 2011-02-08 2019-01-09 FUJIFILM Cellular Dynamics, Inc. Hematopoietic precursor cell production by programming
FR2971256A1 (fr) 2011-02-09 2012-08-10 Bio Rad Pasteur Combinaison de biomarqueurs pour la detection et l'evaluation d'une fibrose hepatique
FR2971258B1 (fr) 2011-02-09 2020-12-04 Bio Rad Pasteur Combinaison de biomarqueurs pour le pronostic d'une reponse ou non-reponse a un traitement anti-vhc
CA2826748C (en) 2011-02-09 2020-08-04 Bio-Rad Laboratories, Inc. Method of detecting variations in copy number of a target nucleic acid
FR2971257B1 (fr) 2011-02-09 2020-12-04 Bio Rad Pasteur Combinaison de biomarqueurs pour le pronostic d'une reponse ou non-reponse a un traitement anti-vhc
EP3412778A1 (en) 2011-02-11 2018-12-12 Raindance Technologies, Inc. Methods for forming mixed droplets
EP3301176B1 (en) 2011-02-11 2019-09-25 The Rockefeller University Method for identifying nucleic acids regulating metastasation
US9266104B2 (en) 2011-02-11 2016-02-23 Raindance Technologies, Inc. Thermocycling device for nucleic acid amplification and methods of use
WO2012112489A2 (en) 2011-02-14 2012-08-23 Theraclone Sciences, Inc. Compositions and methods for the therapy and diagnosis of influenza
WO2012112558A1 (en) 2011-02-14 2012-08-23 The Regents Of The University Of Michigan Compositions and methods for the treatment of obesity and related disorders
JP5847201B2 (ja) 2011-02-15 2016-01-20 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 増大した３’末端ミスマッチ識別能を有するｄｎａポリメラーゼ
WO2012110843A1 (en) 2011-02-18 2012-08-23 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for promoting fibrinolysis and thrombolysis
WO2012112804A1 (en) 2011-02-18 2012-08-23 Raindance Technoligies, Inc. Compositions and methods for molecular labeling
GB201102857D0 (en) 2011-02-18 2011-04-06 Danisco Feed additive composition
BR112013021017B1 (pt) 2011-02-18 2020-04-07 Dupont Nutrition Biosci Aps composição de aditivo de ração, seu método de preparo, método para preparar uma ração e pré mistura
US20120214830A1 (en) 2011-02-22 2012-08-23 OSI Pharmaceuticals, LLC Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors in hepatocellular carcinoma
EP2679664B1 (en) 2011-02-22 2019-10-09 Universal Bio Research Co., Ltd. Reaction container and method for producing same
US9562853B2 (en) 2011-02-22 2017-02-07 Vanderbilt University Nonaqueous backscattering interferometric methods
ES2649912T3 (es) 2011-02-23 2018-01-16 Dupont Nutrition Biosciences Aps Tratamiento enzimático de la clorofila en los aceites vegetales
AR085251A1 (es) 2011-02-23 2013-09-18 Danisco Proceso para tratar aceite vegetal
EP2492354A1 (en) 2011-02-23 2012-08-29 Institut National De La Recherche Agronomique (INRA) Method for identifying compounds useful in the treatment of photosensitive reflex epilepsy
WO2012114339A1 (en) 2011-02-23 2012-08-30 Rappaport Family Institute For Research In The Medical Sciences High affinity molecules capable of binding a type a plexin receptor and uses of same
CA2827200A1 (en) 2011-02-24 2012-08-30 Hill's Pet Nutrition, Inc. Compositions and methods for diagnosing and treating kidney disorders in a feline
US8718948B2 (en) 2011-02-24 2014-05-06 Gen-Probe Incorporated Systems and methods for distinguishing optical signals of different modulation frequencies in an optical signal detector
WO2012158238A2 (en) 2011-02-28 2012-11-22 University Of Iowa Research Foundation Anti-müllerian hormone changes in pregnancy and prediction ofadverse pregnancy outcomes and gender
EP2680839A1 (en) 2011-03-02 2014-01-08 Morphotek, Inc. Co -administration of eribulin and farletuzumab for the treatment of breast cancer
ITVT20110002A1 (it) 2011-03-03 2011-06-02 Molecular Digital Diagnostics S R L Metodo di determinazione dell'origine di fluidi o tracce biologiche e kit di reagenti per la loro identificazione in un campione.
SG10201604479YA (en) 2011-03-03 2016-07-28 Quark Pharmaceuticals Inc Oligonucleotide Modulators Of The Toll-Like Receptor Pathway
US9796979B2 (en) 2011-03-03 2017-10-24 Quark Pharmaceuticals Inc. Oligonucleotide modulators of the toll-like receptor pathway
EP2680864B1 (en) 2011-03-03 2019-05-08 Ramot at Tel-Aviv University Ltd. Genetically modified muscle cells which express neurotrophic factors
AU2012226398B9 (en) 2011-03-06 2017-04-13 Merck Serono S.A. Low fucose cell lines and uses thereof
CA2829300A1 (en) 2011-03-08 2012-09-13 King Abdullah University Of Science And Technology Molecular biomarker set for early detection of ovarian cancer
WO2012120518A1 (en) 2011-03-08 2012-09-13 Ramot At Tel-Aviv University Ltd. Compositions and methods for diagnosing and treating phenylketonuria (pku)
PT3270141T (pt) 2011-03-08 2020-08-28 Univ Laval Dispositivo centrípeto fluídico
WO2012122571A1 (en) 2011-03-10 2012-09-13 Gen-Probe Incorporated Methods and compositions for the selection and optimization of oligonucleotide tag sequences
NL2006378C2 (en) 2011-03-11 2012-09-12 Univ Wageningen Tyclv resistance.
WO2012125614A1 (en) 2011-03-15 2012-09-20 Theraclone Sciences, Inc. Compositions and methods for the therapy and diagnosis of influenza
JP5971769B2 (ja) 2011-03-15 2016-08-17 ザ ユニバーシティー オブ ノースカロライナ アット チャペル ヒル アントラサイクリン療法を用いて乳癌を処置する方法
US20140086839A1 (en) 2011-03-17 2014-03-27 Tel Hashomer Medical Research Infrastructure And Services Ltd. Quinolone analogs for treating autoimmune diseases
JP2014509515A (ja) 2011-03-18 2014-04-21 エーザイ・アール・アンド・ディー・マネジメント株式会社 エリブリンに対する応答を予測するための方法及び組成物
EP3483607A1 (en) 2011-03-18 2019-05-15 Stichting VUmc A method of analysing a blood sample of a subject for the presence of a disease marker
KR101835917B1 (ko) 2011-03-22 2018-03-07 플루리스템 리미티드 방사선 또는 화학적 손상을 치료하는 방법들
US8759044B2 (en) 2011-03-23 2014-06-24 Butamax Advanced Biofuels Llc In situ expression of lipase for enzymatic production of alcohol esters during fermentation
US8765425B2 (en) 2011-03-23 2014-07-01 Butamax Advanced Biofuels Llc In situ expression of lipase for enzymatic production of alcohol esters during fermentation
EP2688908B1 (en) 2011-03-23 2017-06-21 Option Pharmaceuticals, LLC Targeted cytokine for treatment of musculoskeletal diseases
KR20140092759A (ko) 2011-03-24 2014-07-24 부타맥스 어드밴스드 바이오퓨얼스 엘엘씨 숙주 세포 및 아이소부탄올의 제조 방법
US9260753B2 (en) 2011-03-24 2016-02-16 President And Fellows Of Harvard College Single cell nucleic acid detection and analysis
WO2012129758A1 (en) 2011-03-25 2012-10-04 Biomerieux Method and kit for determining in vitro probability for individual to suffer from colorectal cancer
WO2012131680A2 (en) 2011-03-28 2012-10-04 Yeda Research And Development Co. Ltd. Compositions and methods for treating inflammation
CN103534358B (zh) 2011-03-29 2015-03-25 Seegene株式会社 基于pto切割以及延伸-依赖性切割的靶核酸序列的检测
CA2830361C (en) 2011-03-31 2021-03-16 Dana-Farber Cancer Institute, Inc. Methods and compositions to enable multiplex cold-pcr
EP2691518A1 (en) 2011-03-31 2014-02-05 E.I. Du Pont De Nemours And Company Yarrowia diacylglycerol acyltransferase promoter regions for gene expression in yeast
US20120252682A1 (en) 2011-04-01 2012-10-04 Maples Corporate Services Limited Methods and systems for sequencing nucleic acids
US20120247066A1 (en) 2011-04-01 2012-10-04 Ice House America, Llc Ice bagging apparatus and methods
EP2694657A1 (en) 2011-04-05 2014-02-12 E. I. Du Pont de Nemours and Company Yarrowia n-alkane-hydroxylating cytochrome p450 promoter regions for gene expression in yeast
CN103476950B (zh) 2011-04-05 2016-05-11 陶氏益农公司 对转基因边界的高通量分析
WO2012137202A1 (en) 2011-04-05 2012-10-11 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Composition comprising an iron indicator attached to a microparticle and uses of same for quantifying non-transferrin bound iron (ntbi) and cellular labile iron (lci)
CA2832031C (en) 2011-04-06 2019-09-17 Ramot At Tel-Aviv University Ltd. Methods of monitoring and analyzing metabolic activity profiles diagnostic and therapeutic uses of same
US9140698B2 (en) 2011-04-06 2015-09-22 The Board Of Regents Of The University Of Texas System Modulating bacterial MAM polypeptides in pathogenic disease
US8609369B2 (en) 2011-04-07 2013-12-17 E I Du Pont De Nemours And Company Yarrowia peroxisomal 2,4-dienoyl-CoA reductase promoter regions for gene expression in yeast
EP2694534B1 (en) 2011-04-08 2018-06-20 Evaxion Biotech ApS Proteins and nucleic acids useful in vaccines targeting staphylococcus aureus
US9428807B2 (en) 2011-04-08 2016-08-30 Life Technologies Corporation Phase-protecting reagent flow orderings for use in sequencing-by-synthesis
US20120328567A1 (en) 2011-04-08 2012-12-27 Steven Bushnell Biomarkers predictive of therapeutic responsiveness to ifnb and uses thereof
MX2013011617A (es) 2011-04-08 2013-11-21 Danisco Us Inc Composiciones.
JP6072766B2 (ja) 2011-04-08 2017-02-01 バイオ−ラッド ラボラトリーズ インコーポレーティッド 非特異的活性が低下したｐｃｒ反応混合物
CA2831180C (en) 2011-04-11 2017-02-14 Keith Bauer Dna polymerases with improved activity
US9150644B2 (en) 2011-04-12 2015-10-06 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Human monoclonal antibodies that bind insulin-like growth factor (IGF) I and II
GB201106254D0 (en) 2011-04-13 2011-05-25 Frisen Jonas Method and product
US20140157443A1 (en) 2011-04-14 2014-06-05 St. Jude Children's Research Hospital Methods and compositions for detecting and modulating a novel mtor complex
BR112013026451B1 (pt) 2011-04-15 2021-02-09 Becton, Dickinson And Company sistema e método para realizar ensaios de diagnóstico molecular em várias amostras em paralelo e simultaneamente amplificação em tempo real em pluralidade de câmaras de reação de amplificação
ES2768296T3 (es) 2011-04-15 2020-06-22 Pluristem Ltd Métodos y sistemas para recoger células
DK2699700T3 (en) 2011-04-20 2016-08-01 Mesa Biotech Inc Integrated device for nukleinsyreregistrering and identification
GB201106814D0 (en) 2011-04-21 2011-06-01 Astex Therapeutics Ltd New compounds
GB201106817D0 (en) 2011-04-21 2011-06-01 Astex Therapeutics Ltd New compound
WO2012145209A2 (en) 2011-04-21 2012-10-26 Rockefeller University (The) Anti-inflammatory agents
US9657352B2 (en) 2011-04-25 2017-05-23 Gen-Probe Incorporated Compositions and methods for detecting BV-associated bacterial nucleic acid
CA3078215A1 (en) 2011-04-28 2012-11-01 Department Of Veterans Affairs Identification of polynucleotides associated with a sample
CN106912197B (zh) 2011-04-28 2022-01-25 生命技术公司 用于多重pcr的方法和组合物
PL2702159T3 (pl) 2011-04-28 2019-03-29 St. Jude Children's Research Hospital Szczepionka i wektor obrazowania zmodyfikowanego wirusa Sendai
WO2012149193A2 (en) 2011-04-29 2012-11-01 Monsanto Technology Llc Diagnostic molecular markers for seed lot purity traits in soybeans
CN103717750B (zh) 2011-04-29 2017-03-08 塞昆纳姆股份有限公司 少数核酸物质的定量
KR102006393B1 (ko) 2011-04-29 2019-08-02 유니버시티 오브 워싱톤 스루 이츠 센터 포 커머셜리제이션 치료적 뉴클레아제 조성물 및 방법
CA2834680A1 (en) 2011-04-29 2012-11-01 Emory University Selecting use of proteasome inhibitors based on nf-kb2 sequence
US8728798B2 (en) 2011-05-03 2014-05-20 Verdezyne, Inc. Biological methods for preparing adipic acid
US8343752B2 (en) 2011-05-03 2013-01-01 Verdezyne, Inc. Biological methods for preparing adipic acid
ES2625504T3 (es) 2011-05-03 2017-07-19 Dow Agrosciences Llc Integración de genes en el cromosoma de Saccharopolyspora spinosa
CA3139245A1 (en) 2011-05-03 2012-11-08 Evogene Ltd. Isolated polynucleotides and polypeptides and methods of using same for increasing plant yield, biomass, growth rate, vigor, oil content, abiotic stress tolerance of plants and nitrogen use efficiency
WO2012150600A2 (en) 2011-05-04 2012-11-08 Ramot At Tel-Aviv University Ltd. Regulation of amyloid beta molecular composition for the treatment of alzheimer's disease
BR112013027963A2 (pt) 2011-05-05 2016-11-29 Danisco Us Inc "variante de subtilisina com atividade proteolítica, ácido nucleico, vetor de expressão, célula hospedeira, composição e método de limpeza".
MX357386B (es) 2011-05-05 2018-07-06 Procter & Gamble Composiciones y metodos que comprenden variantes de proteasa serina.
US8945588B2 (en) 2011-05-06 2015-02-03 The University Of Chicago Methods and compositions involving protective staphylococcal antigens, such as EBH polypeptides
WO2012153333A1 (en) 2011-05-09 2012-11-15 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Regeneration and repair of mesenchymal tissue using amelogenin
WO2012153153A1 (en) 2011-05-11 2012-11-15 Diagon Kft. Procedure for rapid determination of viruses using nucleic acid-based molecular diagnostics, and a kit for this purpose
GB201107863D0 (en) 2011-05-11 2011-06-22 Olink Ab Method and product
US8993341B2 (en) 2011-05-12 2015-03-31 Exact Sciences Corporation Removal of PCR inhibitors
ES2773692T3 (es) 2011-05-12 2020-07-14 Exact Sciences Corp Aislamiento de ácidos nucleicos
WO2012153336A2 (en) 2011-05-12 2012-11-15 Rakuto Bio Technologies Ltd. Methods and device for lightening skin complexion
US8808990B2 (en) 2011-05-12 2014-08-19 Exact Sciences Corporation Serial isolation of multiple DNA targets from stool
WO2012156976A1 (en) 2011-05-16 2012-11-22 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Methods of producing artemisinin in non-host plants and vectors for use in same
WO2012158818A2 (en) 2011-05-16 2012-11-22 Fabion Pharmaceuticals, Inc. Multi-specific fab fusion proteins and methods of use
EP2710146A2 (en) 2011-05-18 2014-03-26 Life Technologies Corporation Chromosome conformation analysis
US9119824B2 (en) 2011-05-18 2015-09-01 Memorial Sloan-Kettering Cancer Center Methods of use for IL-22 promoting rejuvenation of thymic and bone marrow function
US10435743B2 (en) 2011-05-20 2019-10-08 The Regents Of The University Of California Method to estimate age of individual based on epigenetic markers in biological sample
JP6457263B2 (ja) 2011-05-20 2019-01-23 オリゴメリックス インコーポレイテッド タウプロテアーゼ組成物および使用方法
SG194745A1 (en) 2011-05-20 2013-12-30 Fluidigm Corp Nucleic acid encoding reactions
EP3263127B1 (en) 2011-05-23 2019-08-21 Yeda Research and Development Co. Ltd Use of akt phosphorylation as a biomarker for prognosing neurodegenerative diseases and treating same
WO2012160526A2 (en) 2011-05-23 2012-11-29 Ofir Menashe Formulations of microorganism comprising particles and uses of same
EP2714939B1 (en) 2011-05-24 2015-04-15 Elitech Holding B.V. Detection of methicillin-resistant staphylococcus aureus
CA2837184C (en) 2011-05-25 2021-09-21 Innate Pharma, S.A. Anti-kir antibodies for the treatment of inflammatory and autoimmune disorders
US9034581B2 (en) 2011-05-26 2015-05-19 Roche Molecular Systems, Inc. Compositions and methods for detection of Staphylococcus aureus
WO2012165943A1 (en) 2011-05-27 2012-12-06 Vereniging Voor Christelijk Hoger Onderwijs, Wetenschappelijk Onderzoek En Patiëntenzorg A method of analysing a blood sample of a subject for the presence of an infectious disease marker
US9284351B2 (en) 2011-05-31 2016-03-15 Hutchison Biofilm Medical Solutions Ltd. Dispersion and detachment of cell aggregates
US20140113376A1 (en) 2011-06-01 2014-04-24 Rotem Sorek Compositions and methods for downregulating prokaryotic genes
WO2012166913A1 (en) 2011-06-01 2012-12-06 Streck, Inc. Rapid thermocycler system for rapid amplification of nucleic acids and related methods
WO2012167142A2 (en) 2011-06-02 2012-12-06 Raindance Technolgies, Inc. Enzyme quantification
US10166295B2 (en) 2011-06-02 2019-01-01 Opko Biologics Ltd. Pegylated OXM variants
WO2012169887A2 (en) 2011-06-06 2012-12-13 Stichting Katholieke Universiteit, More Particularly The Radboud University Nijmegen Medical Centre Use of new markers in a diagnostic assay for determining severity of rsv infection
DK2718260T3 (en) 2011-06-08 2018-11-19 Life Technologies Corp DESIGN AND DEVELOPMENT OF NEW DETERGENTS FOR USE IN PCR SYSTEMS
US9567628B2 (en) 2011-06-08 2017-02-14 Life Technologies Corporation Polymerization of nucleic acids using proteins having low isoelectric points
EP2718427B1 (en) 2011-06-08 2017-01-11 Children's Hospital of Eastern Ontario Research Institute Inc. Compositions for glioblastoma treatment
WO2012170793A1 (en) 2011-06-08 2012-12-13 Metabolix, Inc. Biorefinery process for thf production
JP6188686B2 (ja) 2011-06-09 2017-08-30 カッパーアールエヌエー，インコーポレイテッド フラタキシン（ｆｘｎ）への天然アンチセンス転写物の阻害によるｆｘｎ関連疾患の治療
ES2670596T3 (es) 2011-06-14 2018-05-31 Yeda Research And Development Co. Ltd. Terapia de combinación para prevenir la formación del DCIS y la progresión hasta cáncer de mama
US10144969B2 (en) 2011-06-15 2018-12-04 Colgate-Palmolive Company Compositions and methods for diagnosing and monitoring hyperthyroidism in a feline
EP2535712A1 (en) 2011-06-15 2012-12-19 F. Hoffmann-La Roche AG Analytical system for the preparation of biological material
ES2547075T3 (es) 2011-06-16 2015-10-01 Gendiag.Exe, S.L. SNP asociados a enfermedad tromboembólica
CN103814135A (zh) 2011-06-17 2014-05-21 布特马斯先进生物燃料有限责任公司 木质纤维素水解产物作为原料用于异丁醇发酵
EP2721170A2 (en) 2011-06-17 2014-04-23 Life Technologies Corporation Compositions and methods for detection of cronobacter spp. and cronobacter species and strains
US8470573B2 (en) 2011-06-21 2013-06-25 Bio-Rad Laboratories, Inc. Hybrid polymerases having the ability to produce long amplicons
EP2723865B1 (en) 2011-06-21 2019-03-27 Alnylam Pharmaceuticals, Inc. METHODS FOR DETERMINING ACTIVITY OF RNAi IN A SUBJECT
JP2014527398A (ja) 2011-06-21 2014-10-16 オンコファクター コーポレイション がんの療法および診断のための組成物および方法
US10125394B2 (en) 2011-06-22 2018-11-13 Yale University Compositions and methods for diagnosing diseases and disorders associated with β cell death
US9988668B2 (en) 2011-06-23 2018-06-05 Anitoa Systems, Llc Apparatus for amplification of nucleic acids
GB201110833D0 (en) 2011-06-24 2011-08-10 Bold Venture Llc Compositions
WO2012177792A2 (en) 2011-06-24 2012-12-27 Sequenom, Inc. Methods and processes for non-invasive assessment of a genetic variation
US9487824B2 (en) 2011-06-28 2016-11-08 Igor Kutyavin Methods and compositions for enrichment of nucleic acids in mixtures of highly homologous sequences
US20150045540A1 (en) 2011-06-28 2015-02-12 Sea Lane Biotechnologies, Llc Multispecific stacked variable domain binding proteins
KR20140056237A (ko) 2011-06-30 2014-05-09 노보자임스 에이/에스 알파-아밀라제 변이체
CN103747807B (zh) 2011-07-05 2016-12-07 比奥阿赛斯技术有限公司 P97‑抗体缀合物和使用方法
CA3051939C (en) 2011-07-06 2023-08-01 Verdezyne, Inc. Genetically modified yeast with increased alcohol dehydrogenase activity for preparing a fatty dicarboxylic acid
KR101264295B1 (ko) 2011-07-13 2013-07-04 연세대학교 산학협력단 타겟 핵산서열의 계층적 제조방법
GB201112091D0 (en) 2011-07-14 2011-08-31 Gt Biolog Ltd Bacterial strains isolated from pigs
WO2013012733A1 (en) 2011-07-15 2013-01-24 Biogen Idec Ma Inc. Heterodimeric fc regions, binding molecules comprising same, and methods relating thereto
EP3536810B1 (en) 2011-07-15 2023-05-10 Gen-Probe Incorporated Compositions and method for detecting human parvovirus nucleic acid and hepatitis a virus nucleic acid
AR087220A1 (es) 2011-07-20 2014-02-26 Kaiima Bio Agritech Ltd Plantas de maiz que tienen un genoma parcial o completamente multiplicado y sus usos
US8658430B2 (en) 2011-07-20 2014-02-25 Raindance Technologies, Inc. Manipulating droplet size
TW201307553A (zh) 2011-07-26 2013-02-16 Dow Agrosciences Llc 在植物中生產二十二碳六烯酸（ｄｈａ）及其他長鏈多元不飽和脂肪酸（ｌｃ－ｐｕｆａ）之技術
EP2550982A1 (en) 2011-07-27 2013-01-30 Technion Research & Development Foundation Ltd. Devices for surgical applications
US10300140B2 (en) 2011-07-28 2019-05-28 I2 Pharmaceuticals, Inc. Sur-binding proteins against ERBB3
EP2737061B1 (en) 2011-07-28 2015-09-16 Roche Diagnostics GmbH Dna polymerases with improved activity
CN103732761A (zh) 2011-08-03 2014-04-16 伯乐实验室公司 使用透化处理的细胞过滤小核酸
WO2013018060A2 (en) 2011-08-04 2013-02-07 Yeda Research And Development Co. Ltd. Micro-rnas and compositions comprising same for the treatment and diagnosis of serotonin-, adrenalin-, noradrenalin-, glutamate-, and corticotropin-releasing hormone- associated medical conditions
DK2554679T3 (en) 2011-08-05 2016-04-04 Gendiag Exe Sl Genetic markers for risk assessment for cardiovascular disease
EP3321281B1 (en) 2011-08-05 2019-11-27 biOasis Technologies Inc P97 fragments with transfer activity
US20140256590A1 (en) 2011-08-09 2014-09-11 Vereniging Voor Christelijk Hoger Onderwijs Method of analysing a blood sample of a subject for the presence of a foetal disease or condition marker
EP2742143A1 (en) 2011-08-10 2014-06-18 Metabolix, Inc. Post process purification for gamma-butyrolactone production
US20140271680A1 (en) 2011-08-12 2014-09-18 Universite Paris-Est Creteil Val De Marne Methods and pharmaceutical compositions for treatment of pulmonary hypertension
WO2013024175A2 (en) 2011-08-17 2013-02-21 Technische Universität München Diagnostic means and methods for type 2 diabetes
EP3624124B1 (en) 2011-08-18 2023-11-22 Life Technologies Corporation Systems for making base calls in nucleic acid sequencing
US20130122505A1 (en) 2011-08-24 2013-05-16 Life Technologies Corporation Compositions and methods for detection of multiple microorganisms
JP2014526899A (ja) 2011-08-26 2014-10-09 ジェン９・インコーポレイテッド 核酸の高忠実度アセンブリのための組成物および方法
US8822651B2 (en) 2011-08-30 2014-09-02 Theraclone Sciences, Inc. Human rhinovirus (HRV) antibodies
PT3517615T (pt) 2011-08-31 2022-08-09 Seminis Vegetable Seeds Inc Métodos e composições para a firmeza da melancia
US10704164B2 (en) 2011-08-31 2020-07-07 Life Technologies Corporation Methods, systems, computer readable media, and kits for sample identification
EP2751291B1 (en) 2011-09-01 2018-08-15 University of Southern California Methods for preparing high throughput peptidomimetics, orally bioavailable drugs and compositions containing same
EP2753714B1 (en) 2011-09-06 2017-04-12 Gen-Probe Incorporated Circularized templates for sequencing
WO2013036685A1 (en) 2011-09-06 2013-03-14 Gen-Probe Incorporated Closed nucleic acid structures
CN108272782B (zh) 2011-09-06 2021-04-23 库尔纳公司 小分子在制备治疗Dravet综合征或全面性癫痫伴热性惊厥附加症的药物中的用途
US20140248293A1 (en) 2011-09-08 2014-09-04 Yeda Research And Development Co., Ltd Novel risk biomarkers for lung cancer
US9586987B2 (en) 2011-09-08 2017-03-07 Kabushiki Kaisha Dnaform Primer set for isothermal amplication of a target nucleic acid sequence
ES2640813T3 (es) 2011-09-08 2017-11-06 Yeda Research And Development Co. Ltd. Linfocitos T de memoria central antiterceros, métodos para producirlos y uso de los mismos en un trasplante y el tratamiento de enfermedades
US9663829B2 (en) 2011-09-08 2017-05-30 Gen-Probe Incorporated Compositions and methods for detecting BV-associated bacterial nucleic acid
US10040853B2 (en) 2011-09-09 2018-08-07 Fred Hutchinson Cancer Research Center Methods and compositions involving NKG2D inhibitors and cancer
US10385475B2 (en) 2011-09-12 2019-08-20 Adaptive Biotechnologies Corp. Random array sequencing of low-complexity libraries
US8969519B2 (en) 2011-09-13 2015-03-03 Dana-Farber Cancer Institute, Inc. Compositions and methods for brown fat induction and activity using FNDC5
MX343071B (es) 2011-09-13 2016-10-21 Monsanto Technology Llc Metodos y composiciones para el control de malezas.
US9644241B2 (en) 2011-09-13 2017-05-09 Interpace Diagnostics, Llc Methods and compositions involving miR-135B for distinguishing pancreatic cancer from benign pancreatic disease
US10806146B2 (en) 2011-09-13 2020-10-20 Monsanto Technology Llc Methods and compositions for weed control
MX343072B (es) 2011-09-13 2016-10-21 Monsanto Technology Llc Metodos y composiciones para controlar malezas.
US10760086B2 (en) 2011-09-13 2020-09-01 Monsanto Technology Llc Methods and compositions for weed control
US10829828B2 (en) 2011-09-13 2020-11-10 Monsanto Technology Llc Methods and compositions for weed control
ES2645927T3 (es) 2011-09-13 2017-12-11 Monsanto Technology Llc Procedimientos y composiciones para el control de malezas
CN103946398B (zh) 2011-09-15 2019-08-13 健能泰格技术公司 探针：反义探针组合物对高特异性dna或rna的检测
AU2012307282B2 (en) 2011-09-16 2018-03-15 Lexogen Gmbh Nucleic acid transcription method
WO2013044097A1 (en) 2011-09-21 2013-03-28 Gen-Probe Incorporated Methods for amplifying nucleic acid using tag-mediated displacement
WO2013041194A1 (en) 2011-09-23 2013-03-28 Roche Diagnostics Gmbh Use of g-clamp for improved allele-specific pcr
AU2012315852B2 (en) 2011-09-28 2018-03-01 Qualicon Diagnostics, Llc Sequences and their use for detection and characterization of STEC bacteria
ES2602072T3 (es) 2011-09-29 2017-02-17 Trovagene, Inc. Mutaciones en SF3B1 y leucemia linfocítica crónica
USD692162S1 (en) 2011-09-30 2013-10-22 Becton, Dickinson And Company Single piece reagent holder
EP2761305B1 (en) 2011-09-30 2017-08-16 Becton, Dickinson and Company Unitized reagent strip
US10196681B2 (en) 2011-10-06 2019-02-05 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US9367663B2 (en) 2011-10-06 2016-06-14 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US9984198B2 (en) 2011-10-06 2018-05-29 Sequenom, Inc. Reducing sequence read count error in assessment of complex genetic variations
WO2013052907A2 (en) 2011-10-06 2013-04-11 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
WO2013050453A1 (en) 2011-10-07 2013-04-11 Baxter Healthcare S.A. Oxmif as a diagnostic marker
US20130090329A1 (en) 2011-10-07 2013-04-11 Suregene, Llc Methods and Compositions for the Treatment of Psychotic Disorders Through the Identification of the Olanzapine Poor Response Predictor Genetic Signature
GB201117313D0 (en) 2011-10-07 2011-11-16 Gt Biolog Ltd Bacterium for use in medicine
US9575073B2 (en) 2011-10-10 2017-02-21 Rutgers, The State University Of New Jersey Detection of high-risk intraductal papillary mucinous neoplasm and pancreatic adenocarcinoma
US9416153B2 (en) 2011-10-11 2016-08-16 Enzo Life Sciences, Inc. Fluorescent dyes
WO2013054320A1 (en) 2011-10-11 2013-04-18 Tel Hashomer Medical Research Infrastructure And Services Ltd. Antibodies to carcinoembryonic antigen-related cell adhesion molecule (ceacam)
US8688388B2 (en) 2011-10-11 2014-04-01 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
AU2012322018B2 (en) 2011-10-13 2017-09-21 Boston Heart Diagnostics Compositions and methods for treating and preventing coronary heart disease
WO2013055911A1 (en) 2011-10-14 2013-04-18 Dana-Farber Cancer Institute, Inc. Znf365/zfp365 biomarker predictive of anti-cancer response
EP2766498B1 (en) 2011-10-14 2019-06-19 President and Fellows of Harvard College Sequencing by structure assembly
CA2852665A1 (en) 2011-10-17 2013-04-25 Good Start Genetics, Inc. Analysis methods
UY34396A (es) 2011-10-18 2013-05-31 Dow Agrosciences Llc Materiales y métodos para la detección del gen dioxigenasa ariloxialcanoato (aad-12) en las plantas
TWI643868B (zh) 2011-10-18 2018-12-11 艾利倫治療公司 擬肽巨環化合物
CA2792804A1 (en) 2011-10-18 2013-04-18 Dow Agrosciences Llc Materials and methods for detecting the aryloxyalkanoate dioxygenase gene (aad-12) containing event pdab4472-1606 in plants
AU2012324791B2 (en) 2011-10-20 2016-04-14 Qiagen Gmbh Method for verifying a temperature measurement in a micro-environment and system for verifying a temperature measurement in a micro-environment
US9663832B2 (en) 2011-10-21 2017-05-30 Dow Agrosciences Llc Method to determine zygosity of the FAD3 gene in canola using end-point taqman® PCR
US9279159B2 (en) 2011-10-21 2016-03-08 Adaptive Biotechnologies Corporation Quantification of adaptive immune cell genomes in a complex mixture of cells
NO3051026T3 (ko) 2011-10-21 2018-07-28
AU2012325988B2 (en) 2011-10-21 2018-04-19 Dow Agrosciences Llc Method to determine zygosity of the fad2 gene in canola using end-point PCR
US9518303B2 (en) 2011-10-25 2016-12-13 The Board Of Regents Of The University Of Texas System Methods and compositions for identifying enterovirus
WO2013063519A1 (en) 2011-10-26 2013-05-02 Asuragen, Inc. Methods and compositions involving mirna expression levels for distinguishing pancreatic cysts
WO2013061328A2 (en) 2011-10-27 2013-05-02 Yeda Research And Development Co. Ltd. Method of treating cancer
GB201118675D0 (en) 2011-10-28 2011-12-14 Astex Therapeutics Ltd New compounds
JP6238900B2 (ja) 2011-10-28 2017-11-29 ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． Ｎａｅ阻害物質に対する応答のバイオマーカー
EP3246404B1 (en) 2011-10-28 2019-02-27 Danisco US Inc. Variant maltohexaose-forming alpha-amylase variants
GB201118654D0 (en) 2011-10-28 2011-12-07 Astex Therapeutics Ltd New compounds
GB201118652D0 (en) 2011-10-28 2011-12-07 Astex Therapeutics Ltd New compounds
US10837879B2 (en) 2011-11-02 2020-11-17 Complete Genomics, Inc. Treatment for stabilizing nucleic acid arrays
AU2012332517B9 (en) 2011-11-03 2017-08-10 Quark Pharmaceuticals, Inc. Methods and compositions for neuroprotection
EP2773772A1 (en) 2011-11-04 2014-09-10 Oslo Universitetssykehus HF Methods and biomarkers for analysis of colorectal cancer
EP3492604B1 (en) 2011-11-04 2021-01-06 Gen-Probe Incorporated Molecular assay reagents and methods
EP2776848B1 (en) 2011-11-07 2019-12-25 Beckman Coulter, Inc. System and method for transporting sample containers
EP2776843B1 (en) 2011-11-07 2019-03-27 Beckman Coulter, Inc. Centrifuge system and workflow
EP3373015A1 (en) 2011-11-07 2018-09-12 Beckman Coulter Inc. Aliquotter system and workflow
JP6062449B2 (ja) 2011-11-07 2017-01-18 ベックマン コールター， インコーポレイテッド 標本コンテナ検出
KR20140091032A (ko) 2011-11-07 2014-07-18 베크만 컬터, 인코포레이티드 검체 수송 시스템의 자기 감쇠
CN104040352B (zh) 2011-11-07 2016-09-07 贝克曼考尔特公司 机械臂
CN103917665B (zh) 2011-11-09 2016-11-16 纳幕尔杜邦公司 用于沙门氏菌检测的序列和它们的用法
WO2013071233A1 (en) 2011-11-10 2013-05-16 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Methods for detecting infectious agents and a novel virus detected thereby
EP2776470A2 (en) 2011-11-11 2014-09-17 Rinat Neuroscience Corporation Antibodies specific for trop-2 and their uses
US8332160B1 (en) 2011-11-17 2012-12-11 Amyris Biotechnologies, Inc. Systems and methods for engineering nucleic acid constructs using scoring techniques
PT3301177T (pt) 2011-11-18 2020-06-29 Alnylam Pharmaceuticals Inc Agentes de arni, composições e métodos de uso destes para o tratamento de doenças associadas à transtirretina (ttr)
WO2013078019A1 (en) 2011-11-22 2013-05-30 Dow Agrosciences Llc Three dimensional matrix analyses for high throughput sequencing
EP2782930B1 (en) 2011-11-27 2018-07-11 Yeda Research and Development Co. Ltd. Methods of regulating angiogenesis and compositions capable of same
EP2785460B1 (en) 2011-11-29 2021-01-27 Caliper Life Sciences, Inc. Systems and methods for sampling of amplification products
WO2013081864A1 (en) 2011-11-29 2013-06-06 Life Technologies Corporation Methods and compositions for multiplex pcr
CN104053786B (zh) 2011-11-29 2017-06-06 生命技术公司 用于多重pcr的方法和组合物
WO2013080050A2 (en) 2011-11-30 2013-06-06 Universitaetsklinikum Erlangen Methods and compositions for determining responsiveness to treatment with a tnf-alpha inhibitor
GB201120711D0 (en) 2011-12-01 2012-01-11 Univ Erasmus Medical Ct Method for classifying tumour cells
US9689029B2 (en) 2011-12-02 2017-06-27 Caliper Life Sciences, Inc. Systems and methods for sampling of amplification products
EP3381456A1 (en) 2011-12-02 2018-10-03 Fate Therapeutics, Inc. Improved methods for treating ischemia
US8748097B1 (en) 2011-12-02 2014-06-10 President And Fellows Of Harvard College Identification of agents for treating calcium disorders and uses thereof
US9452186B2 (en) 2011-12-02 2016-09-27 Fate Therapeutics, Inc. Enhanced stem cell composition
DE102011120550B4 (de) 2011-12-05 2013-11-07 Gen-Probe Prodesse, Inc. Zusammensetzungen, Verfahren und Kits zur Detektion von Adenovirusnukleinsäuren
EP2788481B1 (en) 2011-12-08 2018-03-07 Roche Diagnostics GmbH Dna polymerases with improved activity
JP2015500279A (ja) 2011-12-08 2015-01-05 イェダ リサーチ アンド デベロップメント カンパニー リミテッド 哺乳動物胎児肺細胞および該細胞の治療的使用
ES2569723T3 (es) 2011-12-08 2016-05-12 F. Hoffmann-La Roche Ag Polimerasas de DNA con actividad mejorada
EP2788480B1 (en) 2011-12-08 2019-01-16 Roche Diagnostics GmbH Dna polymerases with improved activity
EP3904536A1 (en) 2011-12-09 2021-11-03 Adaptive Biotechnologies Corporation Diagnosis of lymphoid malignancies and minimal residual disease detection
DK2788491T3 (en) 2011-12-09 2019-04-01 Danisco Us Inc RIBOSOMAL PROMOTERS FROM B. SUBTILIS FOR PROTEIN PRODUCTION IN MICRO-ORGANISMS
UA116097C2 (uk) 2011-12-11 2018-02-12 Зе Стейт Оф Ізраел, Міністрі Оф Агрікалче Енд Руерал Девелопмент, Агрікалчерал Рісьоч Організейшн, (А.Р.О.), Волкані Сентре Спосіб модуляції провідності устячка рослини
US9499865B2 (en) 2011-12-13 2016-11-22 Adaptive Biotechnologies Corp. Detection and measurement of tissue-infiltrating lymphocytes
US9365883B2 (en) 2011-12-19 2016-06-14 Opticul Diagnostics Ltd. Spectroscopic means and methods for identifying microorganisms in culture
US20130189679A1 (en) 2011-12-20 2013-07-25 The Regents Of The University Of Michigan Pseudogenes and uses thereof
WO2013093921A1 (en) 2011-12-20 2013-06-27 Collplant Ltd. Collagen coated synthetic polymer fibers
EP2607904B1 (en) 2011-12-21 2020-01-15 Roche Diagnostics GmbH Method for disposing of a liquid within an automated analytical system, tip rack assembly and analytical system
US9803188B2 (en) 2011-12-22 2017-10-31 Ibis Biosciences, Inc. Systems and methods for isolating nucleic acids
WO2013093693A1 (en) 2011-12-22 2013-06-27 Rinat Neuroscience Corp. Staphylococcus aureus specific antibodies and uses thereof
WO2013096828A1 (en) 2011-12-22 2013-06-27 Sea Lane Biotechnologies, Llc Surrogate binding proteins
WO2013096798A2 (en) 2011-12-22 2013-06-27 Ibis Biosciences, Inc. Amplification of a sequence from a ribonucleic acid
US20130164193A1 (en) 2011-12-22 2013-06-27 Life Technologies Corporation Sequential lateral flow capillary device for analyte determination
IN2014DN03298A (ko) 2011-12-22 2015-06-26 Danisco Us Inc
ES2811529T3 (es) 2011-12-22 2021-03-12 Yeda Res & Dev Una terapia de combinación para un injerto estable y a largo plazo usando protocolos específicos para el agotamiento de los linfocitos T/B
JP5807542B2 (ja) 2011-12-22 2015-11-10 株式会社島津製作所 対象成分を操作するためのチップデバイス及びそれを用いた方法
US9115394B2 (en) 2011-12-22 2015-08-25 Roche Molecular Systems, Inc. Methods and reagents for reducing non-specific amplification
WO2013096799A1 (en) 2011-12-22 2013-06-27 Ibis Biosciences, Inc. Systems and methods for isolating nucleic acids from cellular samples
US9035039B2 (en) 2011-12-22 2015-05-19 Protiva Biotherapeutics, Inc. Compositions and methods for silencing SMAD4
EP3369818B1 (en) 2011-12-22 2021-06-09 InteRNA Technologies B.V. Mirna for treating head and neck cancer
JP2015511116A (ja) 2011-12-23 2015-04-16 ビオメリューＢｉｏｍｅｒｉｅｕｘ メチシリン耐性黄色ブドウ球菌の変異型ｍｅｃＡ株の検出
US9970061B2 (en) 2011-12-27 2018-05-15 Ibis Biosciences, Inc. Bioagent detection oligonucleotides
EP2797405A1 (en) 2011-12-28 2014-11-05 Kaiima Bio Agritech Ltd. Cultivated sorghum plant having a partially or fully multiplied genome and uses of same
WO2013101750A1 (en) 2011-12-29 2013-07-04 Pioneer Hi-Bred International, Inc. Methods of improving aphid resistance in soybeans
CN104321436A (zh) 2011-12-30 2015-01-28 布特马斯先进生物燃料有限责任公司 醇类的发酵生产
US9316647B2 (en) 2011-12-30 2016-04-19 Somalogic, Inc. Aptamers and diagnostic methods for detecting the EGF receptor
CA2862450A1 (en) 2011-12-30 2013-07-04 Butamax Advanced Biofuels Llc Genetic switches for butanol production
CN104080480A (zh) 2012-01-01 2014-10-01 奇比艾企业有限公司 用于选择性递送治疗剂和诊断剂的endo180靶向微粒
SG11201403764XA (en) 2012-01-12 2014-07-30 Biogen Idec Inc Chimeric factor viii polypeptides and uses thereof
WO2013106494A1 (en) 2012-01-12 2013-07-18 Quark Pharmaceuticals, Inc. Combination therapy for treating hearing and balance disorders
WO2013104660A1 (en) 2012-01-13 2013-07-18 Dupont Nutrition Biosciences Aps Process for treating a plant oil comprising hydrolysing chlorophyll or a chlorophyll derivative and involving partial caustic neutralisation
US9194840B2 (en) 2012-01-19 2015-11-24 Life Technologies Corporation Sensor arrays and methods for making same
JP2015505537A (ja) 2012-01-20 2015-02-23 シー レーン バイオテクノロジーズ， エルエルシー 結合分子コンジュゲート
JP6431769B2 (ja) 2012-01-20 2018-11-28 セクエノム， インコーポレイテッド 実験条件を要因として含める診断プロセス
US9605273B2 (en) 2012-01-23 2017-03-28 Dow Agrosciences Llc Herbicide tolerant cotton event pDAB4468.19.10.3
CA2863083C (en) 2012-01-26 2023-09-19 Longhorn Vaccines And Diagnostics, Llc Composite antigenic sequences and vaccines
WO2013114362A1 (en) 2012-01-30 2013-08-08 Yeda Research And Development Co. Ltd. Fusion proteins comprising type-ii cohesin modules, multi- enzyme complexes comprising same and uses thereof
GB201201547D0 (en) 2012-01-30 2012-03-14 Olink Ab Method and product
WO2013114363A2 (en) 2012-01-30 2013-08-08 Yeda Research And Development Co.Ltd. Antimicrobial agents
US9864846B2 (en) 2012-01-31 2018-01-09 Life Technologies Corporation Methods and computer program products for compression of sequencing data
US9515676B2 (en) 2012-01-31 2016-12-06 Life Technologies Corporation Methods and computer program products for compression of sequencing data
EP2809807B1 (en) 2012-02-01 2019-04-10 Gen-Probe Incorporated Asymmetric hairpin target capture oligomers
DE102012201475B4 (de) 2012-02-01 2014-12-18 Gna Biosolutions Gmbh Verfahren zum Vervielfältigen von Nukleinsäuren
WO2013114373A1 (en) 2012-02-01 2013-08-08 Protalix Ltd. Inhalable liquid formulations of dnase i
WO2013113748A1 (en) 2012-02-02 2013-08-08 Primer Design Ltd Method for detecting and genotyping target nucleic acid
CA2861387A1 (en) 2012-02-02 2013-08-08 Invenra, Inc. High throughput screen for biologically active polypeptides
NZ628213A (en) 2012-02-02 2016-10-28 Univ Texas Adenoviruses expressing heterologous tumor-associated antigens
AU2013214849B2 (en) 2012-02-03 2016-09-01 Becton, Dickinson And Company External files for distribution of molecular diagnostic tests and determination of compatibility between tests
CA2863834A1 (en) 2012-02-06 2013-08-15 Inhibrx Llc Cd47 antibodies and methods of use thereof
WO2013118120A2 (en) 2012-02-06 2013-08-15 Rosetta Green Ltd. Isolated polynucleotides expressing or modulating micrornas or targets of same, transgenic plants comprising same and uses thereof in improving nitrogen use efficiency, abiotic stress tolerance, biomass, vigor or yield of a plant
SG11201403988WA (en) 2012-02-09 2014-10-30 Var2 Pharmaceuticals Aps Targeting of chondroitin sulfate glycans
US20130210659A1 (en) 2012-02-10 2013-08-15 Andrew Watson Molecular diagnostic screening assay
SG11201404608WA (en) 2012-02-13 2014-09-26 Gamida Cell Ltd Mesenchymal stem cells conditioned medium and methods of generating and using the same
HUE053068T2 (hu) 2012-02-14 2021-06-28 Opko Biologics Ltd Hosszú hatástartamú koagulációs faktorok és alkalmazásaik
MX362492B (es) 2012-02-15 2019-01-21 Aileron Therapeutics Inc Macrociclos peptidomiméticos.
ES2690786T3 (es) 2012-02-15 2018-11-22 Novo Nordisk A/S Anticuerpos que se unen a la proteína 1 de reconocimiento de peptidoglicano
PL3564260T3 (pl) 2012-02-15 2023-03-06 Bioverativ Therapeutics Inc. Kompozycje czynnika viii oraz sposoby ich wytwarzania i stosowania
HUE043537T2 (hu) 2012-02-15 2019-08-28 Bioverativ Therapeutics Inc Rekombináns VIII faktor fehérjék
US8987414B2 (en) 2012-02-15 2015-03-24 Aileron Therapeutics, Inc. Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles
US9550830B2 (en) 2012-02-15 2017-01-24 Novo Nordisk A/S Antibodies that bind and block triggering receptor expressed on myeloid cells-1 (TREM-1)
WO2013123432A2 (en) 2012-02-16 2013-08-22 Atyr Pharma, Inc. Histidyl-trna synthetases for treating autoimmune and inflammatory diseases
WO2013123409A1 (en) 2012-02-17 2013-08-22 NVS Technologies, Inc. Polymer scaffolds for assay applications
AU2013222414B2 (en) 2012-02-21 2018-02-15 Cytonics Corporation Systems, compositions, and methods for transplantation
WO2013126765A2 (en) 2012-02-22 2013-08-29 Life Technologies Corporation Sample collection devices, kits and methods of use
JP6329911B2 (ja) 2012-02-22 2018-05-23 ブレインステム バイオテック リミテッド 星状膠細胞作製のためのミクロｒｎａ
EP2844745A2 (en) 2012-02-22 2015-03-11 Brainstem Biotec Ltd. Generation of neural stem cells and motor neurons
WO2013124743A1 (en) 2012-02-22 2013-08-29 Population Genetics Technologies Ltd. Compositions and methods for intramolecular nucleic acid rearrangement ii
KR20220045089A (ko) 2012-02-24 2022-04-12 아뷰터스 바이오파마 코포레이션 트리알킬 양이온성 지질 및 그의 사용 방법
CA2865281C (en) 2012-02-24 2021-11-23 Gen-Probe Prodesse, Inc. Detection of shiga toxin genes in bacteria
EP2817418B1 (en) 2012-02-24 2017-10-11 Raindance Technologies, Inc. Labeling and sample preparation for sequencing
EP2820174B1 (en) 2012-02-27 2019-12-25 The University of North Carolina at Chapel Hill Methods and uses for molecular tags
US9677137B2 (en) 2012-02-27 2017-06-13 Mayo Foundation For Medical Education And Research TBL1XR1 and TP63 translocations
EP3287531B1 (en) 2012-02-28 2019-06-19 Agilent Technologies, Inc. Method for attaching a counter sequence to a nucleic acid sample
US20150101074A1 (en) 2012-03-01 2015-04-09 The State of Israel, Ministry of Agriculture & Rural Development, Agriculture Research Male sterile garlic plants, hybrid offspring of same and methods of generating and using same
EP4155401A1 (en) 2012-03-02 2023-03-29 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
EP2823060B1 (en) 2012-03-05 2018-02-14 Adaptive Biotechnologies Corporation Determining paired immune receptor chains from frequency matched subunits
AU2013228226B2 (en) 2012-03-05 2016-06-02 Seegene, Inc. Detection of nucleotide variation on target nucleic acid sequence by PTO cleavage and extension assay
CN109116033A (zh) 2012-03-06 2019-01-01 塞莱克特生物疗法有限公司 用于选择抗细胞凋亡信号传导细胞的装置和方法及其用途
US20150111758A1 (en) 2012-03-06 2015-04-23 Oslo Universitetssykehus Hf Gene signatures associated with efficacy of postmastectomy radiotherapy in breast cancer
JP5951004B2 (ja) 2012-03-07 2016-07-13 キリンホールディングス株式会社 グリコアルカロイド生合成酵素遺伝子の発現が抑制されているか、または該酵素の活性が変化した植物
ES2691931T3 (es) 2012-03-07 2018-11-29 Yeda Research And Development Co. Ltd. Composiciones para inhibición de quiescina sulfhidrilo oxidasa (QSOX1) y usos de las mismas
CN110438125A (zh) 2012-03-15 2019-11-12 科纳公司 通过抑制脑源神经营养因子(bdnf)的天然反义转录物治疗bdnf相关疾病
GB2561425B (en) 2012-03-16 2019-01-16 Cambridge Entpr Ltd Apparatus for obtaining liquid from a solid phase
US10039777B2 (en) 2012-03-20 2018-08-07 Neuro-Lm Sas Methods and pharmaceutical compositions of the treatment of autistic syndrome disorders
CN104736721B (zh) 2012-03-20 2019-02-01 陶氏益农公司 向日葵(Helianthus annuus)低棕榈酸含量的分子标记及其使用方法
WO2013139479A1 (en) 2012-03-21 2013-09-26 Institut Gustave Roussy (Igr) New diagnostic markers of specific chronic myelomonocytic leukemia (cmml)
US9150853B2 (en) 2012-03-21 2015-10-06 Gen9, Inc. Methods for screening proteins using DNA encoded chemical libraries as templates for enzyme catalysis
US9334308B2 (en) 2012-03-22 2016-05-10 Ramot At Tel-Aviv University Ltd. PLIF multimeric peptides and uses thereof
US20130276157A1 (en) 2012-03-23 2013-10-17 Genus, Plc Cyb5 and cyp17 mutations for alteration of 16-androstene steroid synthesis and reduced boar taint in pigs
US9688995B2 (en) 2012-03-23 2017-06-27 Kirin Holdings Kabushiki Kaisha Gene encoding enzyme that reduces position 24 of steroid skeleton and plant in which expression level of the gene is lowered
CA2868805C (en) 2012-03-28 2018-09-04 Longhorn Vaccines And Diagnostics, Llc Compositions and methods for the collection and isolation of nucleic acids from biological specimens
US9803239B2 (en) 2012-03-29 2017-10-31 Complete Genomics, Inc. Flow cells for high density array chips
PL2830662T3 (pl) 2012-03-29 2019-02-28 The Trustees Of Columbia University In The City Of New York Sposoby leczenia zaburzeń utraty włosów
WO2013151647A1 (en) 2012-04-02 2013-10-10 Life Technologies Corporation Compositions and methods for detection of mycobacterium avium paratuberculosis
US9732387B2 (en) 2012-04-03 2017-08-15 The Regents Of The University Of Michigan Biomarker associated with irritable bowel syndrome and Crohn's disease
US8209130B1 (en) 2012-04-04 2012-06-26 Good Start Genetics, Inc. Sequence assembly
EP2834371B1 (en) 2012-04-05 2019-01-09 The Regents of The University of California Gene expression panel for breast cancer prognosis
US8812422B2 (en) 2012-04-09 2014-08-19 Good Start Genetics, Inc. Variant database
WO2013156989A1 (en) 2012-04-18 2013-10-24 Ramot At Tel-Aviv University Ltd. Lipidated glycosaminoglycan particles for the delivery of nucleic acids
EP3461910B1 (en) 2012-04-19 2020-08-26 Life Technologies Corporation Nucleic acid amplification
CN114854832A (zh) 2012-04-19 2022-08-05 生命技术公司 核酸扩增
CN104487082A (zh) 2012-04-19 2015-04-01 奥普科生物制品有限公司 长效胃泌酸调节素变体及其生产方法
EP3524692A1 (en) 2012-04-20 2019-08-14 T2 Biosystems, Inc. Compositions and methods for detection of candida species
AU2013205110B2 (en) 2012-04-24 2016-10-13 Gen-Probe Incorporated Compositions, Methods and Kits to Detect Herpes Simplex Virus Nucleic Acids
WO2013160895A1 (en) 2012-04-24 2013-10-31 Biokine Therapeutics Ltd. Peptides and use thereof in the treatment of large cell lung cancer
EP2842068B1 (en) 2012-04-24 2021-12-08 Laboratory Corporation of America Holdings Methods and systems for identification of a protein binding site
US10081807B2 (en) 2012-04-24 2018-09-25 Gen9, Inc. Methods for sorting nucleic acids and multiplexed preparative in vitro cloning
AR090558A1 (es) 2012-04-24 2014-11-19 Pioneer Hi Bred Int Evento de maiz dp-004114-3 y metodos para su deteccion
DK2844275T3 (da) 2012-04-26 2020-07-13 Univ Chicago Staphylokok-koagulase-antigener og fremgangsmåder til anvendelse af disse
US9156915B2 (en) 2012-04-26 2015-10-13 Thomas Jefferson University Anti-GCC antibody molecules
WO2013160372A1 (en) 2012-04-27 2013-10-31 Dupont Nutrition Biosciences Aps Process for treating plant oil involving addition of serial doses of chlorophyll or chlorophyll derivative degrading enzyme
WO2013160374A1 (en) 2012-04-27 2013-10-31 Dupont Nutrition Biosciences Aps Process for refining crude plant oil involving enzymatic hydrolysis and gum recycling
EP3524693A1 (en) 2012-04-30 2019-08-14 Raindance Technologies, Inc. Digital analyte analysis
US9163263B2 (en) 2012-05-02 2015-10-20 The Goodyear Tire & Rubber Company Identification of isoprene synthase variants with improved properties for the production of isoprene
ES2833524T3 (es) 2012-05-02 2021-06-15 Ibis Biosciences Inc Secuenciación de ADN
SG11201407107VA (en) 2012-05-08 2014-11-27 Adaptive Biotechnologies Corp Compositions and method for measuring and calibrating amplification bias in multiplexed pcr reactions
EP2846819B1 (en) 2012-05-09 2017-05-03 Yeda Research and Development Co. Ltd. Variants of tace pro-domain as tnf-a inhibitor and their medical use
MX362705B (es) 2012-05-10 2019-02-01 Bioatla Llc Anticuerpos monoclonales multiespecíficos.
KR20150014953A (ko) 2012-05-11 2015-02-09 부타맥스 어드밴스드 바이오퓨얼스 엘엘씨 케톨-산 리덕토아이소머라아제 효소 및 사용 방법
US9646132B2 (en) 2012-05-11 2017-05-09 Life Technologies Corporation Models for analyzing data from sequencing-by-synthesis operations
US9133490B2 (en) 2012-05-16 2015-09-15 Transgenomic, Inc. Step-up method for COLD-PCR enrichment
US10504613B2 (en) 2012-12-20 2019-12-10 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
WO2013177220A1 (en) 2012-05-21 2013-11-28 The Scripps Research Institute Methods of sample preparation
WO2013177206A2 (en) 2012-05-21 2013-11-28 Fluidigm Corporation Single-particle analysis of particle populations
GB201208926D0 (en) 2012-05-21 2012-07-04 Vela Operations Pte Ltd Extraction control for DNA
US9920361B2 (en) 2012-05-21 2018-03-20 Sequenom, Inc. Methods and compositions for analyzing nucleic acid
US8865158B2 (en) 2012-05-22 2014-10-21 Ramot At Tel-Aviv University Ltd. Bacteriophages for reducing toxicity of bacteria
US9844582B2 (en) 2012-05-22 2017-12-19 Massachusetts Institute Of Technology Synergistic tumor treatment with extended-PK IL-2 and therapeutic agents
IN2014DN09195A (ko) 2012-05-23 2015-07-10 Du Pont
US10240161B2 (en) 2012-05-24 2019-03-26 A.B. Seeds Ltd. Compositions and methods for silencing gene expression
WO2013174432A1 (en) 2012-05-24 2013-11-28 Fundació Institut D'investigació Biomèdica De Bellvitge (Idibell) Method for the identification of the origin of a cancer of unknown primary origin by methylation analysis
WO2013174997A1 (en) 2012-05-25 2013-11-28 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment of refractory haematological malignancies
WO2013173923A1 (en) 2012-05-25 2013-11-28 Diamedica, Inc. Formulations of human tissue kallikrein-1 for parenteral delivery and related methods
GB201209609D0 (en) 2012-05-30 2012-07-11 Astex Therapeutics Ltd New compounds
GB201209613D0 (en) 2012-05-30 2012-07-11 Astex Therapeutics Ltd New compounds
US9731048B2 (en) 2012-06-03 2017-08-15 Ben-Gurion University Of The Negev Research And Development Authority Functionalized titanium binding peptides and implants coated with same
CN109096387B (zh) 2012-06-04 2021-11-30 奥普科生物制品有限公司 聚乙二醇化的oxm变体
AU2013205064B2 (en) 2012-06-04 2015-07-30 Gen-Probe Incorporated Compositions and Methods for Amplifying and Characterizing HCV Nucleic Acid
SI2854841T1 (sl) 2012-06-04 2017-06-30 Diamedica Inc. Glikozilacijske izooblike humanega tkivnega kalikreina-1
WO2013184754A2 (en) 2012-06-05 2013-12-12 President And Fellows Of Harvard College Spatial sequencing of nucleic acids using dna origami probes
ES2673872T3 (es) 2012-06-05 2018-06-26 The Board Of Trustees Of The Leland Stanford Junior University Mimético del péptido NCAM para su uso en el tratamiento de trastorno de depresión mayor
AU2013271378A1 (en) 2012-06-07 2014-12-18 Beth Israel Deaconess Medical Center, Inc. Methods and compositions for the inhibition of Pin1
US9628676B2 (en) 2012-06-07 2017-04-18 Complete Genomics, Inc. Imaging systems with movable scan mirrors
US9850192B2 (en) 2012-06-08 2017-12-26 Cj Cheiljedang Corporation Renewable acrylic acid production and products made therefrom
EP4026902A1 (en) 2012-06-08 2022-07-13 Danisco US Inc. Variant alpha amylases with enhanced activity on starch polymers
US9085761B1 (en) 2012-06-14 2015-07-21 Affymetrix, Inc. Methods and compositions for amplification of nucleic acids
EP2861757B1 (en) 2012-06-14 2019-11-06 Life Technologies Corporation Novel compositions, methods and kits for polymerase chain reaction (pcr)
US20130337442A1 (en) 2012-06-15 2013-12-19 Pioneer Hi-Bred International, Inc. Genetic loci associated with soybean cyst nematode resistance and methods of use
US9347075B2 (en) 2012-06-19 2016-05-24 E I Du Pont De Nemours And Company Nucleic acids encoding mutant acyl-CoA:lysophosphatidylcholine acyltransferases
WO2013192292A1 (en) 2012-06-21 2013-12-27 Justin Lamb Massively-parallel multiplex locus-specific nucleic acid sequence analysis
US10497461B2 (en) 2012-06-22 2019-12-03 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US9890215B2 (en) 2012-06-22 2018-02-13 King's College London Vista modulators for diagnosis and treatment of cancer
WO2014039983A1 (en) 2012-09-07 2014-03-13 The Trustees Of Dartmouth College Vista modulators for diagnosis and treatment of cancer
WO2014004393A1 (en) 2012-06-25 2014-01-03 Gen9, Inc. Methods for nucleic acid assembly and high throughput sequencing
US20140004105A1 (en) 2012-06-29 2014-01-02 Sequenom, Inc. Age-related macular degeneration diagnostics
US20140005061A1 (en) 2012-06-29 2014-01-02 Life Technologies Corporation Compositions and methods for detection of multiple microorganisms
WO2014005076A2 (en) 2012-06-29 2014-01-03 The Regents Of The University Of Michigan Methods and biomarkers for detection of kidney disorders
US9834823B2 (en) 2012-07-02 2017-12-05 The Translational Genomics Research Institute Primers, assays and methods for detecting an E. coli subtype
EP2870110A1 (en) 2012-07-03 2015-05-13 Nanospun Technologies Ltd. Methods and devices for adsorption and biodegradation of petroleum
US9732144B2 (en) 2012-07-05 2017-08-15 Ohio State Innovation Foundation Infectious bursal disease (IBDV) vaccine compositions
NZ703366A (en) 2012-07-11 2018-03-23 Amunix Operating Inc Factor viii complex with xten and von willebrand factor protein, and uses thereof
CN104619863A (zh) 2012-07-13 2015-05-13 生命技术公司 采用一组snp的人身份识别
WO2014011928A1 (en) 2012-07-13 2014-01-16 Sequenom, Inc. Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses
AU2013205087B2 (en) 2012-07-13 2016-03-03 Gen-Probe Incorporated Method for detecting a minority genotype
EP2872166B1 (en) 2012-07-16 2021-09-08 Yale University Compositions and methods for detecting, treating and preventing diseases and disorders
US9695416B2 (en) 2012-07-18 2017-07-04 Siemens Healthcare Diagnostics Inc. Method of normalizing biological samples
EP2687294A1 (en) 2012-07-18 2014-01-22 Qiagen Instruments AG Rotor for a thermal cycler and thermal cycler
JP6200501B2 (ja) 2012-07-20 2017-09-20 プレジデント アンド フェローズ オブ ハーバード カレッジ 栄養医薬品および医薬品のための細胞ベース品質管理バイオアッセイ
WO2014018375A1 (en) 2012-07-23 2014-01-30 Xenon Pharmaceuticals Inc. Cyp8b1 and uses thereof in therapeutic and diagnostic methods
US9567569B2 (en) 2012-07-23 2017-02-14 Gamida Cell Ltd. Methods of culturing and expanding mesenchymal stem cells
BR112015001690A2 (pt) 2012-07-24 2017-11-07 Pharmacyclics Inc mutações associadas com a resistência a inibidores da tirosina quinase de bruton (btk)
AU2013295770A1 (en) 2012-07-27 2015-01-29 Zoetis Services Llc Tick toxin compositions
EP2880155B1 (en) 2012-07-29 2019-04-17 Yeda Research and Development Co., Ltd. Use of the reductive glycine pathway for generating formatotrophic and autotrophic microorganisms
AU2013202808B2 (en) 2012-07-31 2014-11-13 Gen-Probe Incorporated System and method for performing multiplex thermal melt analysis
CN104919054A (zh) 2012-07-31 2015-09-16 胡安·卡洛斯·海梅 获得并检测待鉴定对象之标志物的方法、相关标志物、认证方法以及验证方法
JP6340366B2 (ja) 2012-07-31 2018-06-06 イェダ リサーチ アンド デベロップメント カンパニー リミテッド 運動ニューロン疾患を診断および処置する方法
WO2014022759A1 (en) 2012-08-03 2014-02-06 Dana-Farber Cancer Institute, Inc. Agents that modulate immune cell activation and methods of use thereof
ES2813407T3 (es) 2012-08-06 2021-03-23 Brainstorm Cell Therapeutics Ltd Métodos para generar células madre mesenquimales que secretan factores neurotróficos
US20150283266A1 (en) 2012-08-09 2015-10-08 The Regents Of The University Of California Cd25 pre-selective combination anti-hiv vectors, targeting vectors, and methods of use
US9139835B2 (en) 2012-08-10 2015-09-22 University Of Iowa Research Foundation Nucleic acid aptamers
WO2014025398A1 (en) 2012-08-10 2014-02-13 Streck, Inc. Real-time optical system for polymerase chain reaction
DK2882496T3 (da) 2012-08-13 2019-11-11 Univ Rockefeller Behandling og diagnosticering af melanom
DK3435084T3 (da) 2012-08-16 2023-05-30 Mayo Found Medical Education & Res Prostatakræftprognose under anvendelse af biomarkører
US9982313B2 (en) 2012-08-17 2018-05-29 Roche Molecular Systems, Inc. Compositions and methods for detection of herpes simplex virus 1 and 2
US9605276B2 (en) 2012-08-24 2017-03-28 Etubics Corporation Replication defective adenovirus vector in vaccination
CA2883219C (en) 2012-08-30 2020-12-29 Gen-Probe Incorporated Multiphase nucleic acid amplification
US20140065110A1 (en) 2012-08-31 2014-03-06 The Regents Of The University Of California Genetically modified msc and therapeutic methods
US20140068814A1 (en) 2012-09-03 2014-03-06 A.B. Seeds Ltd. Method of improving abiotic stress tolerance of plants and plants generated thereby
US9937205B2 (en) 2012-09-04 2018-04-10 The Trustees Of The University Of Pennsylvania Inhibition of diacylglycerol kinase to augment adoptive T cell transfer
EP2893035B1 (en) 2012-09-06 2018-05-02 Life Technologies Corporation Multiplex y-str analysis
US9689042B2 (en) 2012-09-07 2017-06-27 The Regents Of The University Of California Use of glycolytic pathways for inhibiting or measuring oncogenic signaling
EP2895620B1 (en) 2012-09-11 2017-08-02 Life Technologies Corporation Nucleic acid amplification
WO2014043143A1 (en) 2012-09-11 2014-03-20 Life Technologies Corporation Nucleic acid amplification
EP2895197B1 (en) 2012-09-12 2020-02-26 Ramot at Tel-Aviv University Ltd. Immunoparticles and methods of generating and using same
CA2880290C (en) 2012-09-12 2020-10-27 Quark Pharmaceuticals, Inc. Double-stranded oligonucleotide molecules targeting p53 and methods of use thereof
EP2895608B1 (en) 2012-09-12 2018-12-05 Quark Pharmaceuticals, Inc. Double-stranded oligonucleotide molecules to p53 and methods of use thereof
GB201216387D0 (en) 2012-09-13 2012-10-31 Ge Healthcare Uk Ltd Solid matrix for one step nucleic acid amplification
EP2708605A1 (en) 2012-09-17 2014-03-19 Institut Gustave Roussy (IGR) ANKRD26 as a marker for diagnosis of thrombocytopenias
EP2897633B1 (en) 2012-09-18 2020-01-01 UTI Limited Partnership Treatment of pain by inhibition of usp5 de-ubiquitinase
ES2790841T3 (es) 2012-09-23 2020-10-29 Univ Erasmus Med Ct Rotterdam Betacoronavirus humano del Linaje C e identificación de la dipeptidil peptidasa N-terminal como su receptor viral
US9212392B2 (en) 2012-09-25 2015-12-15 Exact Sciences Corporation Normalization of polymerase activity
EP2900811B1 (en) 2012-09-26 2018-12-19 Butamax Advanced Biofuels LLC Polypeptides with ketol-acid reductoisomerase activity
US9914968B2 (en) 2012-09-26 2018-03-13 Cepheid Honeycomb tube
CN105189779B (zh) 2012-10-01 2018-05-11 适应生物技术公司 通过适应性免疫受体多样性和克隆性表征进行的免疫能力评估
US10662477B2 (en) 2012-10-01 2020-05-26 Millennium Pharmaceuticals, Inc. Biomarkers and methods to predict response to inhibitors and uses thereof
US9273330B2 (en) 2012-10-03 2016-03-01 Butamax Advanced Biofuels Llc Butanol tolerance in microorganisms
US20150246095A1 (en) 2012-10-03 2015-09-03 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the prophylactic treatment of bacterial superinfections post-influenza
WO2014055117A1 (en) 2012-10-04 2014-04-10 Asuragen, Inc. Diagnostic mirnas for differential diagnosis of incidental pancreatic cystic lesions
US10482994B2 (en) 2012-10-04 2019-11-19 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
BR112015007606A2 (pt) 2012-10-04 2018-01-30 Univ Leland Stanford Junior métodos e reagentes para a detecção, quantificação e serotipagem de vírus da dengue
CA3120521A1 (en) 2012-10-04 2014-04-10 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
WO2014057490A1 (en) 2012-10-09 2014-04-17 Ramot At Tel-Aviv University Ltd. Methods and kits for predicting prognosis of cancer using soluble mortalin in blood
GB201218195D0 (en) 2012-10-10 2012-11-21 Istituto Zooprofilattico Sperimentale Delle Venezie Composition
WO2014057045A1 (en) 2012-10-10 2014-04-17 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for treatment of gastrointestinal stromal tumors
US10329608B2 (en) 2012-10-10 2019-06-25 Life Technologies Corporation Methods, systems, and computer readable media for repeat sequencing
CN110093330B (zh) 2012-10-12 2023-11-28 丹尼斯科美国公司 包含脂解酶变体的组合物和方法
US20150307865A1 (en) 2012-10-15 2015-10-29 Novo Nordisk Health Care Ag Coagulation factor vii polypeptides
US9133510B2 (en) 2012-10-15 2015-09-15 Life Technologies Corporation Compositions, methods, systems and kits for target nucleic acid enrichment
EP3901280A1 (en) 2012-10-17 2021-10-27 Spatial Transcriptomics AB Methods and product for optimising localised or spatial detection of gene expression in a tissue sample
EP2722399A1 (en) 2012-10-18 2014-04-23 Roche Diagniostics GmbH Method for preventing high molecular weight products during amplification
ES2659747T3 (es) 2012-10-18 2018-03-19 F. Hoffmann-La Roche Ag Ensayo de doble sonda para la detección de poblaciones heterogéneas de amplicón
US9476089B2 (en) 2012-10-18 2016-10-25 President And Fellows Of Harvard College Methods of making oligonucleotide probes
EP2909341A2 (en) 2012-10-18 2015-08-26 Oslo Universitetssykehus HF Biomarkers for cervical cancer
US10226744B2 (en) 2012-10-19 2019-03-12 Danisco Us Inc Stabilization of biomimetic membranes
US9395369B2 (en) 2012-10-19 2016-07-19 Regents Of The University Of Minnesota Guinea pig cytomegalovirus (CIDMTR strain)
AU2013336237A1 (en) 2012-10-22 2015-06-11 Sabag-Rfa Ltd A system for delivering therapeutic agents into living cells and cells nuclei
US9958448B2 (en) 2012-10-23 2018-05-01 Caris Life Sciences Switzerland Holdings Gmbh Aptamers and uses thereof
BR112015009103A2 (pt) 2012-10-23 2017-07-04 Harrisvaccines Inc método para proteger um animal invertebrado aquático contra o vírus da mionecrose infecciosa (imnv), método para produzir um composição e composição
US10942184B2 (en) 2012-10-23 2021-03-09 Caris Science, Inc. Aptamers and uses thereof
WO2014064682A1 (en) 2012-10-24 2014-05-01 Yeda Research And Development Co. Ltd. Combinations of epidermal growth factor receptor targeting antibodies for treating cancer
WO2014068553A1 (en) 2012-10-29 2014-05-08 Yeda Research And Development Co. Ltd. Aptamers, multimeric aptamers and uses thereof
EP2728015A1 (en) 2012-10-31 2014-05-07 INSERM (Institut National de la Santé et de la Recherche Médicale) Method for the Sezary's Syndrome diagnosis
EP2914344B1 (en) 2012-10-31 2020-01-15 The Rockefeller University Treatment of metastatic colon cancer
EP2728013A1 (en) 2012-10-31 2014-05-07 Universitätsspital Basel Method for the simultaneous amplification of a plurality of different nucleic acid target sequences
EP2914256B1 (en) 2012-11-01 2019-07-31 Aileron Therapeutics, Inc. Disubstituted amino acids and methods of preparation and use thereof
DK2914741T3 (da) 2012-11-02 2017-11-20 Life Technologies Corp Hidtil ukendte sammensætninger og fremgangsmåder til forbedring af PCR-specificitet
EP2914618B1 (en) 2012-11-02 2017-07-26 Novartis Tiergesundheit AG Flavivirus associated with theiler's disease
CN104781400A (zh) 2012-11-05 2015-07-15 丹尼斯科美国公司 包含嗜热菌蛋白酶变体的组合物和方法
EP2917348A1 (en) 2012-11-06 2015-09-16 InteRNA Technologies B.V. Combination for use in treating diseases or conditions associated with melanoma, or treating diseases or conditions associated with activated b-raf pathway
EP2917368A1 (en) 2012-11-07 2015-09-16 Good Start Genetics, Inc. Methods and systems for identifying contamination in samples
WO2014074755A1 (en) 2012-11-07 2014-05-15 Yale University Assessing risk of reading and language impairment
JP6445446B2 (ja) 2012-11-08 2018-12-26 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル 骨転移の治療のための方法及び医薬組成物
AU2013342218A1 (en) 2012-11-08 2015-06-04 Wafergen, Inc. Extraction of restrained liquid from wells
CN104955963A (zh) 2012-11-14 2015-09-30 欧凌科公司 Rca报告探针及其用于检测核酸分子的用途
BR122020018510B1 (pt) 2012-11-20 2023-03-14 Opko Biologics Ltd Método para aumentar incrementalmente o tamanho hidrodinâmico de um fator de coagulação ativado viia
US9710596B2 (en) 2012-11-21 2017-07-18 Exact Sciences Corporation Methods for quantifying nucleic acid variations
CA2892361A1 (en) 2012-11-28 2014-06-05 Merck Sharp & Dohme Corp. Use of a wee1 inhibitor for treating a cancer characterized by low pkmyt1 expression levels
BR112015002626A2 (pt) 2012-11-29 2017-09-26 Yeda Res & Dev métodos para prevenção de metástases tumorais, tratamento e prognostico do câncer e identificação dos agentes que são inibidores da metástase putativa
WO2015079413A2 (en) 2013-11-28 2015-06-04 Yeda Research And Development Co. Ltd. Synaptojanin-2 inhibitors and uses thereof
CN103114131B (zh) 2012-11-30 2018-10-02 珠海市坤元农业科技有限公司 一种引物中部序列干扰pcr技术
EP2738263A1 (en) 2012-11-30 2014-06-04 Fundacion para la Investigacion del Hospital Clinico de la Comunidad Valenciana Methods for DNA rearrengements analysis
US9457053B2 (en) 2012-11-30 2016-10-04 Accelerated Biosciences Corp. Methods of differentiating stem cells by modulating MIR-124
US9618428B2 (en) 2012-11-30 2017-04-11 Ge Healthcare Uk Limited Biometric device and means for electronic storage and retrieval of biometric data
US10314253B2 (en) 2012-12-04 2019-06-11 Seminis Vegetable Seeds, Inc. Methods and compositions for watermelon sex expression
LT2929031T (lt) 2012-12-05 2018-02-12 Alnylam Pharmaceuticals, Inc. Pcsk9 irna kompozicijos ir jų naudojimo būdai
AU2013205090B2 (en) 2012-12-07 2016-07-28 Gen-Probe Incorporated Compositions and Methods for Detecting Gastrointestinal Pathogen Nucleic Acid
EP2740805B1 (en) 2012-12-07 2019-02-20 SuppreMol GmbH Stratification and treatment of patients suffering from idiopathic thrombocytopenic purpura
WO2014089536A1 (en) 2012-12-07 2014-06-12 Invitae Corporation Multiplex nucleic acid detection methods
US10036007B2 (en) * 2012-12-11 2018-07-31 Celemics, Inc. Method of synthesis of gene library using codon randomization and mutagenesis
CN114176586A (zh) 2012-12-14 2022-03-15 明德拉公司 用于检测和获取生物标志物的方法和装置
EP2935564A2 (en) 2012-12-19 2015-10-28 Verdezyne, Inc. Biological methods for preparing a fatty dicarboxylic acid
US9551704B2 (en) 2012-12-19 2017-01-24 Dna Electronics, Inc. Target detection
US9939443B2 (en) 2012-12-19 2018-04-10 Caris Life Sciences Switzerland Holdings Gmbh Compositions and methods for aptamer screening
US9804069B2 (en) 2012-12-19 2017-10-31 Dnae Group Holdings Limited Methods for degrading nucleic acid
US9995742B2 (en) 2012-12-19 2018-06-12 Dnae Group Holdings Limited Sample entry
US9599610B2 (en) 2012-12-19 2017-03-21 Dnae Group Holdings Limited Target capture system
US10000557B2 (en) 2012-12-19 2018-06-19 Dnae Group Holdings Limited Methods for raising antibodies
SG11201504837WA (en) 2012-12-19 2015-07-30 Verdezyne Inc Biological methods for preparing a fatty dicarboxylic acid
US9434940B2 (en) 2012-12-19 2016-09-06 Dna Electronics, Inc. Methods for universal target capture
EP2934572A4 (en) 2012-12-20 2016-11-23 Biomatrica Inc FORMULATIONS AND METHODS FOR STABILIZING PCR REAGENTS
EP2934751B1 (en) 2012-12-21 2019-05-29 Micronics, Inc. Low elasticity films for microfluidic use
US10065186B2 (en) 2012-12-21 2018-09-04 Micronics, Inc. Fluidic circuits and related manufacturing methods
CA2896723C (en) 2012-12-28 2024-02-13 Precision Biologics, Inc. Humanized monoclonal antibodies and methods of use for the diagnosis and treatment of colon and pancreas cancer
WO2014105840A1 (en) 2012-12-31 2014-07-03 Butamax Advanced Biofuels Llc Fermentative production of alcohols
US10041068B2 (en) 2013-01-01 2018-08-07 A. B. Seeds Ltd. Isolated dsRNA molecules and methods of using same for silencing target molecules of interest
CA2836403A1 (en) 2013-01-04 2014-07-04 Board Of Trustees Of Michigan State University New sources of aphid resistance in soybean plants
WO2014108854A1 (en) 2013-01-09 2014-07-17 Fusimab Ltd. Monospecific anti-hgf and anti-ang2 antibodies and bispecific anti-hgf/anti-ang2 antibodies
WO2014108850A2 (en) 2013-01-09 2014-07-17 Yeda Research And Development Co. Ltd. High throughput transcriptome analysis
CA2894472C (en) 2013-01-17 2021-08-17 Novellusdx Ltd. Methods and systems for identifying patient specific driver mutations
CN105190656B (zh) 2013-01-17 2018-01-16 佩索纳里斯公司 用于遗传分析的方法和系统
CA2897997A1 (en) 2013-01-21 2014-07-24 Abbvie Inc. Anti-tnf and anti-il17 combination therapy biomarkers for inflammatory disease
US10125373B2 (en) 2013-01-22 2018-11-13 Arizona Board Of Regents On Behalf Of Arizona State University Geminiviral vector for expression of rituximab
WO2014114928A1 (en) 2013-01-23 2014-07-31 Astrazeneca Ab Chemical compounds
EP2948566A4 (en) 2013-01-24 2016-10-05 California Inst Of Techn CHROMOPHORE-BASED CHARACTERIZATION AND DETECTION METHODS
US10077475B2 (en) 2013-01-24 2018-09-18 California Institute Of Technology FRET-based analytes detection and related methods and systems
WO2014116989A1 (en) 2013-01-25 2014-07-31 Pioneer Hi-Bred International, Inc. Maize event dp-032218-9 and methods for detection thereof
US20130309666A1 (en) 2013-01-25 2013-11-21 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
EP2948552A4 (en) 2013-01-28 2016-08-24 Univ Kansas State RIFTTALFIEBERVIRUS GLYCOPROTEINS GN AND GC AND THEIR USE
US9567615B2 (en) 2013-01-29 2017-02-14 Terravia Holdings, Inc. Variant thioesterases and methods of use
US9896728B2 (en) 2013-01-29 2018-02-20 Arcticrx Ltd. Method for determining a therapeutic approach for the treatment of age-related macular degeneration (AMD)
US9816079B2 (en) 2013-01-29 2017-11-14 Terravia Holdings, Inc. Variant thioesterases and methods of use
WO2014118785A1 (en) 2013-02-04 2014-08-07 Ramot At Tel-Aviv University Ltd. Generation of cytotoxic tumor specific cell lines and uses thereof
US8956821B2 (en) 2013-02-06 2015-02-17 Medical Service Consultation International, Llc Methods and compositions for detecting Aspergillus terreus, Aspergillus niger, and mycotoxins
CA2900468A1 (en) 2013-02-06 2014-08-14 Inhibrx Llc Non-platelet depleting and non-red blood cell depleting cd47 antibodies and methods of use thereof
WO2014122199A1 (en) 2013-02-06 2014-08-14 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for treatment of chronic intestinal pseudo-obstruction
PL2956477T3 (pl) 2013-02-15 2021-06-14 Bioverativ Therapeutics Inc. Zoptymalizowany gen czynnika viii
US10351910B2 (en) 2013-02-20 2019-07-16 Pluristem Ltd Gene and protein expression properties of adherent stromal cells cultured in 3D
ES2900102T3 (es) 2013-02-20 2022-03-15 Univ Emory Composiciones para la secuenciación de ácidos nucleicos en mezclas
CA2901501C (en) 2013-02-21 2023-03-07 Children's Hospital Of Eastern Ontario Research Institute Inc. Vaccine composition
EP2959012B1 (en) 2013-02-21 2018-02-14 Qualicon Diagnostics LLC Sequences and their use for detection and characterization of e. coli o157:h7
AU2014200958B2 (en) 2013-02-25 2016-01-14 Seegene, Inc. Detection of nucleotide variation on target nucleic acid sequence
JP6416793B2 (ja) 2013-02-28 2018-10-31 カプリオン プロテオミクス インコーポレーテッド 結核のバイオマーカー及びその使用
US10398661B2 (en) 2013-02-28 2019-09-03 The Board Of Regents Of The University Of Texas System Methods for classifying a cancer as susceptible to TMEPAI-directed therapies and treating such cancers
US9783817B2 (en) 2013-03-04 2017-10-10 Arkansas State University Methods of expressing and detecting activity of expansin in plant cells
AU2014225788B2 (en) 2013-03-05 2018-03-29 Baylor College Of Medicine Engager cells for immunotherapy
JP6622591B2 (ja) 2013-03-06 2019-12-18 プロタリクス リミテッド ＴＮＦαポリペプチド阻害薬を発現する植物細胞の、治療法における使用
US20160017020A1 (en) 2013-03-06 2016-01-21 Protalix Ltd. Chimeric polypeptides, polynucleotides encoding same, cells expressing same and methods of producing same
US9963740B2 (en) 2013-03-07 2018-05-08 APDN (B.V.I.), Inc. Method and device for marking articles
EP3456818B1 (en) 2013-03-07 2020-05-20 Baylor College of Medicine Targeting cd138 in cancer
WO2014135984A2 (en) 2013-03-07 2014-09-12 Recopharma Ab Glycosylated mucin-immunoglobulin fusion protein coated device
EP3385717A3 (en) 2013-03-09 2018-10-24 Harry Stylli Methods of detecting prostate cancer
EP2964764A1 (en) 2013-03-09 2016-01-13 Baylor College Of Medicine Vascular-targeted t-cell therapy
EP4202441A3 (en) 2013-03-09 2023-07-26 Immunis.AI, Inc. Gene expression profile in macrophages for the diagnosis of cancer
EP2971095B1 (en) 2013-03-12 2019-11-20 Life Technologies Corporation Universal reporter-based genotyping methods, reaction mixture and kit
EP2971185A4 (en) 2013-03-13 2017-03-08 Monsanto Technology LLC Methods and compositions for weed control
WO2014168711A1 (en) 2013-03-13 2014-10-16 Sequenom, Inc. Primers for dna methylation analysis
AU2014248958A1 (en) 2013-03-13 2015-10-01 Monsanto Technology Llc Methods and compositions for weed control
US9718858B2 (en) 2013-03-13 2017-08-01 Trustees Of Boston University Tunable control of protein degradation in synthetic and endogenous bacterial systems
US10640808B2 (en) 2013-03-13 2020-05-05 Abbott Molecular Inc. Systems and methods for isolating nucleic acids
BR112015022416A2 (pt) 2013-03-13 2017-10-24 Bioasis Technologies Inc fragmentos de p97 e seus usos
KR101943623B1 (ko) 2013-03-13 2019-01-30 주식회사 씨젠 멜팅 피크 분석을 이용한 타겟 핵산서열의 정량
US9701999B2 (en) 2013-03-14 2017-07-11 Abbott Molecular, Inc. Multiplex methylation-specific amplification systems and methods
US8778609B1 (en) 2013-03-14 2014-07-15 Good Start Genetics, Inc. Methods for analyzing nucleic acids
WO2014159650A2 (en) 2013-03-14 2014-10-02 Mayo Foundation For Medical Education And Research Detecting neoplasm
WO2014140165A1 (en) 2013-03-14 2014-09-18 Dsm Ip Assets B.V. Cell wall deconstruction enzymes of paecilomyces byssochlamydoides and uses thereof
WO2014140167A1 (en) 2013-03-14 2014-09-18 Dsm Ip Assets B.V. Cell wall deconstruction enzymes of malbranchea cinnamomea and uses thereof
US20140296080A1 (en) 2013-03-14 2014-10-02 Life Technologies Corporation Methods, Systems, and Computer Readable Media for Evaluating Variant Likelihood
US20140274736A1 (en) 2013-03-14 2014-09-18 Abbott Molecular Inc. Minimizing errors using uracil-dna-n-glycosylase
US9255290B2 (en) 2013-03-14 2016-02-09 The Regents Of The University Of California Methods and devices for non-therman polymerase chain reaction
WO2014160129A2 (en) 2013-03-14 2014-10-02 Alnylam Pharmaceuticals, Inc. Complement component c5 irna compositions and methods of use thereof
WO2014159850A2 (en) 2013-03-14 2014-10-02 Codexis, Inc. Low-phosphate repressible promoter
JP2016511010A (ja) 2013-03-14 2016-04-14 イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニーＥ．Ｉ．Ｄｕ Ｐｏｎｔ Ｄｅ Ｎｅｍｏｕｒｓ Ａｎｄ Ｃｏｍｐａｎｙ ブタノール製造用のグリセロール３−ホスフェートデヒドロゲナーゼ
AU2013202805B2 (en) 2013-03-14 2015-07-16 Gen-Probe Incorporated System and method for extending the capabilities of a diagnostic analyzer
US9580705B2 (en) 2013-03-15 2017-02-28 Butamax Advanced Biofuels Llc DHAD variants and methods of screening
KR102451570B1 (ko) 2013-03-15 2022-10-06 시버스 유에스 엘엘씨 올리고뉴클레오타이드 매개 유전자 보수를 사용한 표적화된 유전자 변형의 효율을 증가시키기 위한 방법 및 조성물
US9943545B2 (en) 2013-03-15 2018-04-17 Fate Therapeutics, Inc. Stem cell culture media and methods of enhancing cell survival
WO2014145340A2 (en) 2013-03-15 2014-09-18 Trovagene, Inc. Detection of nucleic acids in urine
US9290749B2 (en) 2013-03-15 2016-03-22 Solazyme, Inc. Thioesterases and cells for production of tailored oils
US10294489B2 (en) 2013-03-15 2019-05-21 Board Of Trustees Of Southern Illinois University Soybean resistant to cyst nematodes
US10119134B2 (en) 2013-03-15 2018-11-06 Abvitro Llc Single cell bar-coding for antibody discovery
EP2968551B1 (en) 2013-03-15 2021-05-05 The Trustees of Columbia University in the City of New York Fusion proteins and methods thereof
CN111366434A (zh) 2013-03-15 2020-07-03 赛拉诺斯知识产权有限责任公司 用于使样品中的细胞破裂的自动化测定装置
CN105229141A (zh) 2013-03-15 2016-01-06 拉勒曼德匈牙利流动管理有限责任公司 用于木质纤维素和相关低聚物的水解的β-葡糖苷酶的表达
US9828629B2 (en) 2013-03-15 2017-11-28 Roche Molecular Systems, Inc. Nucleic acid target identification by structure based probe cleavage
US10851412B2 (en) 2013-03-15 2020-12-01 Fate Therapeutics, Inc. Cell potency assay for therapeutic potential
SG11201507273SA (en) 2013-03-15 2015-10-29 Theranos Inc Nucleic acid amplification
US9957515B2 (en) 2013-03-15 2018-05-01 Cibus Us Llc Methods and compositions for targeted gene modification
US10568328B2 (en) 2013-03-15 2020-02-25 Monsanto Technology Llc Methods and compositions for weed control
US10933417B2 (en) 2013-03-15 2021-03-02 Nanobiosym, Inc. Systems and methods for mobile device analysis of nucleic acids and proteins
BR112015022470B1 (pt) 2013-03-15 2021-08-24 Becton, Dickinson And Company Sonda ou iniciador de oligonucleotídeo, método para determinar presença da sequência do gene de proteína externa principal (opca) de neisseria gonorrhoeae e composições para detecção de neisseria gonorrhoeae
WO2014150910A1 (en) 2013-03-15 2014-09-25 Ibis Biosciences, Inc. Dna sequences to assess contamination in dna sequencing
WO2014144666A2 (en) 2013-03-15 2014-09-18 The University Of Chicago Methods and compositions related to t-cell activity
EP2969218A2 (en) 2013-03-15 2016-01-20 Nanobiosym, Inc. Systems and methods for mobile device analysis of nucleic acids and proteins
CA2903874C (en) 2013-03-15 2024-02-20 Theranos, Inc. Nucleic acid amplification
CA2906805A1 (en) 2013-03-15 2014-09-18 Theranos, Inc. Nucleic acid amplification
CA2903873C (en) 2013-03-15 2023-09-05 Theranos, Inc. Thermostable blunt-end ligase and methods of use
US9528137B2 (en) 2013-03-15 2016-12-27 Northwestern University Methods for cell-free protein synthesis
WO2014153408A1 (en) 2013-03-19 2014-09-25 Directed Genomics, Llc Enrichment of target sequences
KR101403507B1 (ko) 2013-03-21 2014-06-09 주식회사 현일바이오 결핵균 및 비결핵 마이코박테리아의 선택적 검출 방법, 그리고 이를 이용한 키트
WO2014147622A1 (en) 2013-03-21 2014-09-25 Collplant Ltd. Compositions comprising collagen and prp for tissue regeneration
WO2014160797A1 (en) 2013-03-26 2014-10-02 Genetag Technology, Inc. Dual probe:antiprobe compositions for dna and rna detection
WO2015060511A1 (ko) 2013-10-22 2015-04-30 주식회사 바이오이즈 생체분자와 핵산의 결합정보를 생성하기 위한 마커, 이의 제조방법, 이를 이용한 생체분자 분석방법 및 장치
EP4187543A1 (en) 2013-04-03 2023-05-31 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
WO2014166836A1 (en) 2013-04-05 2014-10-16 Novo Nordisk A/S Growth hormone compound formulation
GB201306536D0 (en) 2013-04-10 2013-05-22 Gt Biolog Ltd Polypeptide and immune modulation
EP2986627B1 (en) 2013-04-18 2019-04-10 Carmel Haifa University Economic Corporation Ltd. Inhibitors of the eph-a receptor and uses thereof
EP2986762B1 (en) 2013-04-19 2019-11-06 Bio-Rad Laboratories, Inc. Digital analyte analysis
CA2909380A1 (en) 2013-04-21 2014-10-30 Yeda Research And Development Co. Ltd. Agents for downregulation of the activity and/or amount of bcl-xl and/or bcl-w
EP2988773A2 (en) 2013-04-22 2016-03-02 Institut National De La Recherche Agronomique (INRA) Par-4 antagonists for use in the treatment or prevention of influenza virus type a infections
CN105492624B (zh) 2013-04-23 2019-10-18 恩姆菲舍尔科技公司 熔解曲线分析
WO2014174470A1 (en) 2013-04-23 2014-10-30 Yeda Research And Development Co. Ltd. Isolated naive pluripotent stem cells and methods of generating same
US9714268B2 (en) 2013-04-25 2017-07-25 Yeda Research And Development Co. Ltd. Use of inhibitory peptides for the treatment of inflammatory diseases
GB201307577D0 (en) 2013-04-26 2013-06-12 Astex Therapeutics Ltd New compounds
CA2910553A1 (en) 2013-04-30 2014-11-06 Universite De Montreal Novel biomarkers for acute myeloid leukemia
ES2727898T3 (es) 2013-05-02 2019-10-21 Univ Michigan Regents Amlexanox deuterado con estabilidad metabólica mejorada
WO2014182847A1 (en) 2013-05-07 2014-11-13 Micronics, Inc. Device for preparation and analysis of nucleic acids
CA2911303C (en) 2013-05-07 2021-02-16 Micronics, Inc. Methods for preparation of nucleic acid-containing samples using clay minerals and alkaline solutions
CN105189560A (zh) 2013-05-07 2015-12-23 瑞纳神经科学公司 抗胰高血糖素受体抗体和其使用方法
GB201308313D0 (en) 2013-05-09 2013-06-19 Medical Res Council Assay Method
US10072300B2 (en) 2013-05-21 2018-09-11 Biomerieux Kit for the prognosis of colorectal cancer
EP3000896B1 (en) 2013-05-21 2020-09-30 Universal Bio Research Co., Ltd. Device and method for pretreating sequencer
BR112015029139B1 (pt) 2013-05-22 2022-07-12 Alnylam Pharmaceuticals, Inc Agente de rnai de fita dupla para inibição da expressão de serpina1 em uma célula, seus usos, bem como composição farmacêutica e método in vitro de inibição da expressão de serpina1 em uma célula
CN105452463B (zh) 2013-05-22 2019-06-21 阿尔尼拉姆医药品有限公司 Tmprss6 irna组合物及其使用方法
MX2015015891A (es) 2013-05-22 2016-06-02 Telomere Diagnostics Inc Mediciones de abundancia de telomeros cortos.
CA2910205C (en) 2013-05-24 2023-04-04 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
ES2771048T3 (es) 2013-05-27 2020-07-06 Rakuto Bio Tech Ltd Composiciones cosméticas que contienen sistemas enzimáticos
JP6286031B2 (ja) 2013-05-28 2018-02-28 アストラゼネカ アクチボラグ 化合物
EP3005200A2 (en) 2013-06-03 2016-04-13 Good Start Genetics, Inc. Methods and systems for storing sequence read data
US10059999B2 (en) 2013-06-10 2018-08-28 Monsanto Technology Llc Molecular markers associated with soybean tolerance to low iron growth conditions
EP3008211A4 (en) 2013-06-11 2016-12-21 Courtagen Life Sciences Inc METHOD AND KITS FOR TREATMENT AND CLASSIFICATION OF PERSONS WITHOUT THE RISK OF AN EXISTING OR EXISTING TRAP1 FUNCTIONAL CHANGE
WO2014199364A1 (en) 2013-06-13 2014-12-18 Bnai Zion Medical Center Semaphorin 3a for treatment and prognosis of systemic lupus erythematosus
CR20200207A (es) 2013-06-14 2020-07-19 Monsanto Technology Llc EVENTO TRANSGÈNICO DE SOJA MON87751 Y MÈTODOS PARA SU DETECCIÒN Y USO (Divisional 2016-0020)
US9428748B2 (en) 2013-06-17 2016-08-30 Hong Gao Method of expanding hematopoietic stem cells
JP6159161B2 (ja) 2013-06-18 2017-07-05 キリン株式会社 ステロイド骨格の１６位を酸化する酵素をコードする遺伝子および該遺伝子の発現が低下した植物体
ES2728307T3 (es) 2013-06-21 2019-10-23 Danisco Us Inc Composiciones y métodos para la transformación clostridial
US10622094B2 (en) 2013-06-21 2020-04-14 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
ES2938044T3 (es) 2013-06-24 2023-04-04 Univ Ramot Estructura a base de epiplón y sistema de suministro
US9879313B2 (en) 2013-06-25 2018-01-30 Prognosys Biosciences, Inc. Methods and systems for determining spatial patterns of biological targets in a sample
EP3495803A1 (en) 2013-06-28 2019-06-12 Streck, Inc. Devices for real-time polymerase chain reaction
US9708657B2 (en) 2013-07-01 2017-07-18 Adaptive Biotechnologies Corp. Method for generating clonotype profiles using sequence tags
EP4023750A1 (en) 2013-07-01 2022-07-06 Massachusetts Institute of Technology Functionalization of endogenous bacteria
WO2015000014A1 (en) 2013-07-01 2015-01-08 Newsouth Innovations Pty Limited Diagnosis and treatment of autoimmune diseases
WO2015001082A1 (en) 2013-07-05 2015-01-08 INSERM (Institut National de la Santé et de la Recherche Médicale) Novel alternative splice transcripts for mhc class i related chain alpha (mica) and uses thereof
DE102013213279B4 (de) 2013-07-06 2024-03-28 Ist Innuscreen Gmbh Universelles Verfahren zur Detektion von diversen Analyten in Form von Nukleinsäuresequenzen
CA2917961A1 (en) 2013-07-10 2015-01-15 Joseph A. Majzoub Mrap2 knockouts
US9856536B2 (en) 2013-07-15 2018-01-02 The Cleveland Clinic Foundation Method for treating castration-resistant prostate cancer
US9850496B2 (en) 2013-07-19 2017-12-26 Monsanto Technology Llc Compositions and methods for controlling Leptinotarsa
CN105980567B (zh) 2013-07-19 2021-04-16 孟山都技术有限公司 用于控制叶甲属的组合物和方法
JP6620093B2 (ja) 2013-07-23 2019-12-11 アービュートゥス バイオファーマ コーポレイションＡｒｂｕｔｕｓ Ｂｉｏｐｈａｒｍａ Ｃｏｒｐｏｒａｔｉｏｎ メッセンジャーｒｎａを送達するための組成物及び方法
US9828624B2 (en) 2013-07-24 2017-11-28 Boston Heart Diagnostics Corporation Driving patient compliance with therapy
WO2015015489A1 (en) 2013-07-30 2015-02-05 Biolinerx Ltd. Antibody for treating diabetes and autoimmune diseases
EP3027222A1 (en) 2013-07-31 2016-06-08 QBI Enterprises Ltd. Sphingolipid-polyalkylamine-oligonucleotide compounds
WO2015017529A2 (en) 2013-07-31 2015-02-05 Dana-Farber Cancer Institute, Inc. Compositions and methods for modulating thermogenesis using pth-related and egf-related molecules
US20160208247A1 (en) 2013-07-31 2016-07-21 Qbi Enterprises Ltd. Methods of use of sphingolipid polyalkylamine oligonucleotide compounds
TWI623551B (zh) 2013-08-02 2018-05-11 輝瑞大藥廠 抗ｃｘｃｒ４抗體及抗體－藥物結合物
EP3875106A1 (en) 2013-08-08 2021-09-08 Bioverativ Therapeutics Inc. Purification of chimeric fviii molecules
WO2015023892A1 (en) 2013-08-14 2015-02-19 Gen-Probe Incorporated Compositions and methods for detecting hev nucleic acid
TW202003554A (zh) 2013-08-14 2020-01-16 美商百歐維拉提夫治療公司 因子ｖｉｉｉ－ｘｔｅｎ融合物及其用途
WO2015023851A1 (en) 2013-08-14 2015-02-19 The Governing Council Of The University Of Toronto Antibodies against frizzled proteins and methods of use thereof
IL228026B (en) 2013-08-19 2018-05-31 Technion Res & Dev Foundation Discovery of genetic sequences using pna sensors and isotachophoresis
AU2014309047A1 (en) 2013-08-20 2016-02-11 Qualicon Diagnostics, Llc Sequences and their use for detection of Salmonella enteritidis and/or Salmonella typhimurium
US9898575B2 (en) 2013-08-21 2018-02-20 Seven Bridges Genomics Inc. Methods and systems for aligning sequences
CN105658801A (zh) 2013-08-27 2016-06-08 诺沃吉公司 经工程改造以利用非常规的磷或硫源的微生物
BR112016004153A2 (pt) 2013-08-28 2019-09-17 Caris Life Sciences Switzerland Holdings Gmbh "método para caracterizar uma doença ou distúrbio, kit, composição, método para gerar uma biblioteca de entrada, oligonucleotídeo, pluralidade de oligonucleotídeos e método para identificar um aptâmero
AU2014312249A1 (en) 2013-08-28 2016-03-24 Cytonics Corporation Systems, compositions, and methods for transplantation and treating conditions
US9938316B2 (en) 2013-08-29 2018-04-10 Yeda Research And Development Co. Ltd. Selective inhibitors of α2 isoform of Na,K-ATPase and use thereof for reduction of intra-ocular pressure and as cardiotonic agents
GB2534067B (en) 2013-08-30 2021-07-21 Personalis Inc Methods and systems for genomic analysis
IL228284A (en) 2013-09-03 2016-12-29 Technion Res & Dev Foundation Implants from cellular scaffolding and blood vessel stalk
US20160251410A1 (en) 2013-09-03 2016-09-01 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Compositions and methods for expressing recombinant polypeptides
US10760065B2 (en) 2013-09-05 2020-09-01 Massachusetts Institute Of Technology Tuning microbial populations with programmable nucleases
WO2015033344A1 (en) 2013-09-05 2015-03-12 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Methods and kits for inhibiting pathogenicity of group a streptococcus (gas) or group g streptococcus (ggs)
EP3042208A4 (en) 2013-09-06 2017-04-19 Theranos, Inc. Systems and methods for detecting infectious diseases
CA2923667A1 (en) 2013-09-09 2015-03-12 Triact Therapeutics, Inc. Cancer therapy
AU2014317861B2 (en) 2013-09-09 2019-11-28 Figene, Llc Gene therapy for the regeneration of chondrocytes or cartilage type cells
WO2015035377A1 (en) 2013-09-09 2015-03-12 British Columbia Cancer Agency Branch Methods and kits for predicting outcome and methods and kits for treating breast cancer with radiation therapy
EP3044313B1 (en) 2013-09-12 2019-11-06 Danisco US Inc. Compositions and methods comprising lg12-clade protease variants
WO2015037009A1 (en) 2013-09-16 2015-03-19 Plexicure Ltd. Isolated proteins capable of binding plexin-a4 and methods of producing and using same
WO2015040609A1 (en) 2013-09-17 2015-03-26 Yeda Research And Development Co. Ltd. Erk-derived peptides and uses thereof
WO2015042564A1 (en) 2013-09-23 2015-03-26 Alnylam Pharmaceuticals, Inc. Methods for treating or preventing transthyretin (ttr) associated diseases
EP3521431A1 (en) 2013-09-25 2019-08-07 Cornell University Compounds for inducing anti-tumor immunity and methods thereof
EP3757130A1 (en) 2013-09-26 2020-12-30 Costim Pharmaceuticals Inc. Methods for treating hematologic cancers
WO2015049677A1 (en) 2013-10-01 2015-04-09 Kadimastem Ltd. Directed differentiation of astrocytes from human pluripotent stem cells for use in drug screening and the treatment of amyotrophic lateral sclerosis (als)
WO2015049370A1 (en) 2013-10-03 2015-04-09 Novozymes A/S Detergent composition and use of detergent composition
WO2015051275A1 (en) 2013-10-03 2015-04-09 Personalis, Inc. Methods for analyzing genotypes
EP3052193B1 (en) 2013-10-03 2018-01-31 Oklahoma Medical Research Foundation Biomarkers for systemic lupus erythematosus disease activity, and intensity and flare
CN105683980B (zh) 2013-10-04 2018-08-24 生命科技股份有限公司 在使用终止化学物质的测序中建立分阶段效应模型的方法和系统
US11901041B2 (en) 2013-10-04 2024-02-13 Bio-Rad Laboratories, Inc. Digital analysis of nucleic acid modification
CA2926436A1 (en) 2013-10-07 2015-04-16 Judith Murrah Multimode image and spectral reader
CA2925111C (en) 2013-10-07 2024-01-16 Sequenom, Inc. Methods and processes for non-invasive assessment of chromosome alterations
US11041203B2 (en) 2013-10-18 2021-06-22 Molecular Loop Biosolutions, Inc. Methods for assessing a genomic region of a subject
EP3058332B1 (en) 2013-10-18 2019-08-28 Seven Bridges Genomics Inc. Methods and systems for genotyping genetic samples
WO2015058095A1 (en) 2013-10-18 2015-04-23 Seven Bridges Genomics Inc. Methods and systems for quantifying sequence alignment
WO2015058120A1 (en) 2013-10-18 2015-04-23 Seven Bridges Genomics Inc. Methods and systems for aligning sequences in the presence of repeating elements
JP2016533182A (ja) 2013-10-18 2016-10-27 セブン ブリッジズ ジェノミクス インコーポレイテッド 疾患に誘導された変異を同定するための方法およびシステム
US10851414B2 (en) 2013-10-18 2020-12-01 Good Start Genetics, Inc. Methods for determining carrier status
US20150158926A1 (en) 2013-10-21 2015-06-11 Opko Biologics, Ltd. Long-acting polypeptides and methods of producing and administering same
US9063914B2 (en) 2013-10-21 2015-06-23 Seven Bridges Genomics Inc. Systems and methods for transcriptome analysis
JP6325667B2 (ja) 2013-10-21 2018-05-16 キム・ソンチョン オリゴヌクレオチドを用いた生体分子分析方法及び装置
KR102444140B1 (ko) 2013-10-21 2022-09-15 옵코 바이오로직스 리미티드 장시간-작용하는 폴리펩티드, 그의 생산 방법, 및 그의 투여 방법
US10767156B2 (en) 2013-10-24 2020-09-08 Yeda Research And Development Co., Ltd. Polynucleotides encoding BREX system polypeptides and methods of using same
JP6415582B2 (ja) 2013-10-25 2018-10-31 ウェイン ステート ユニバーシティー タンパク質誘導生体内細胞リプログラミングによる細胞転換に関する方法、システム、及び組成物
EP3060682B1 (en) 2013-10-25 2023-08-30 Livestock Improvement Corporation Limited Genetic markers and uses therefor
US20160272997A1 (en) 2013-10-25 2016-09-22 Pioneer Hi-Bred International, Inc. Stem canker tolerant soybeans and methods of use
WO2015061714A1 (en) 2013-10-25 2015-04-30 Life Technologies Corporation Novel compounds for use in pcr systems and applications thereof
CN105722977A (zh) 2013-10-30 2016-06-29 绿色生活生物技术有限责任公司 用于柑橘绿化枯萎病的发病定量系统和治疗方法
WO2015066550A1 (en) 2013-10-31 2015-05-07 Resolve Therapeutics, Llc Therapeutic nuclease-albumin fusions and methods
WO2015063604A2 (en) 2013-11-01 2015-05-07 Imberti Luisa BIOMARKERS PREDICTIVE OF THERAPEUTIC RESPONSIVENESS TO IFNβ AND USES THEREOF
MX2016005778A (es) 2013-11-04 2016-12-20 Monsanto Technology Llc Composiciones y metodos para controlar infestaciones de plagas y parasitos de los artropodos.
WO2015066695A1 (en) 2013-11-04 2015-05-07 Exact Sciences Corporation Multiple-control calibrators for dna quantitation
CN104623637A (zh) 2013-11-07 2015-05-20 健能隆医药技术（上海）有限公司 Il-22二聚体在制备静脉注射药物中的应用
WO2015070050A1 (en) 2013-11-08 2015-05-14 Baylor Research Institute Nuclear loclization of glp-1 stimulates myocardial regeneration and reverses heart failure
US20170002064A1 (en) 2013-11-08 2017-01-05 The Board Of Regents Of The University Of Texas System Vh4 antibodies against gray matter neuron and astrocyte
US10072288B2 (en) 2013-11-11 2018-09-11 Roche Molecular Systems, Inc. Detecting single nucleotide polymorphism using overlapped primer and melting probe
WO2015073580A1 (en) 2013-11-13 2015-05-21 Pfizer Inc. Tumor necrosis factor-like ligand 1a specific antibodies and compositions and uses thereof
CA2930595C (en) 2013-11-14 2023-09-19 Integrated Dna Technologies, Inc. Dna polymerase mutants having enhanced template discrimination activity
CA2928014A1 (en) 2013-11-15 2015-05-21 Institut Pasteur Method for detecting a molecular marker of plasmodium falciparum artemisinin resistance
CN114317461A (zh) 2013-11-22 2022-04-12 德那翠丝有限公司 表达免疫细胞刺激受体激动剂的腺病毒
WO2015075166A1 (en) 2013-11-22 2015-05-28 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for treatment of a bacterial infection
GB201320729D0 (en) 2013-11-25 2014-01-08 Cancer Rec Tech Ltd Therapeutic compounds and their use
GB201320732D0 (en) 2013-11-25 2014-01-08 Cancer Rec Tech Ltd Methods of chemical synthesis
US10801070B2 (en) 2013-11-25 2020-10-13 The Broad Institute, Inc. Compositions and methods for diagnosing, evaluating and treating cancer
WO2015081178A1 (en) 2013-11-26 2015-06-04 Illumina, Inc. Compositions and methods for polynucleotide sequencing
NZ718164A (en) 2013-11-27 2017-04-28 Seminis Vegetable Seeds Inc Disease resistance loci in onion
WO2015079411A1 (en) 2013-11-28 2015-06-04 Tel Hashomer Medical Research Infrastructure And Services Ltd. Rna polymerase i inhibitors and uses thereof
WO2015079446A1 (en) 2013-11-29 2015-06-04 Technion Research & Development Foundation Limited Metod and device for accelerated surface-based reactions
EP2878681B1 (en) 2013-11-29 2020-03-04 Technion Research And Development Foundation, Ltd. Continuous cell detection by isotachophoresis
ES2693217T3 (es) 2013-12-02 2018-12-10 Personal Genome Diagnostics Inc. Método para evaluar variantes minoritarias en una muestra
WO2015082536A1 (en) 2013-12-03 2015-06-11 Evaxion Biotech Aps Proteins and nucleic acids useful in vaccines targeting staphylococcus aureus
WO2015085147A1 (en) 2013-12-05 2015-06-11 The Broad Institute Inc. Polymorphic gene typing and somatic change detection using sequencing data
CN111793640A (zh) 2013-12-06 2020-10-20 奥驰亚客户服务公司 烟草植物及使用此类植物的方法
WO2015085230A1 (en) 2013-12-06 2015-06-11 Bio-Rad Laboratories, Inc. Fusion polymerases
WO2015087187A1 (en) 2013-12-10 2015-06-18 Rinat Neuroscience Corp. Anti-sclerostin antibodies
US9476853B2 (en) 2013-12-10 2016-10-25 Life Technologies Corporation System and method for forming microwells
UA119253C2 (uk) 2013-12-10 2019-05-27 Біолоджикс, Інк. Спосіб боротьби із вірусом у кліща varroa та у бджіл
US9944977B2 (en) 2013-12-12 2018-04-17 Raindance Technologies, Inc. Distinguishing rare variations in a nucleic acid sequence from a sample
AU2014362262B2 (en) 2013-12-12 2021-05-13 Alnylam Pharmaceuticals, Inc. Complement component iRNA compositions and methods of use thereof
WO2015089438A1 (en) 2013-12-13 2015-06-18 Northwestern University Biomarkers for post-traumatic stress states
US10280431B2 (en) 2013-12-18 2019-05-07 Nutech Ventures Acyltransferases and methods of using
EP3084004A4 (en) 2013-12-19 2017-08-16 Exact Sciences Corporation Synthetic nucleic acid control molecules
GB201322574D0 (en) 2013-12-19 2014-02-05 Equigerminal Sa Retroviral peptides
DK3083936T3 (en) 2013-12-19 2018-10-22 Danisco Us Inc USE OF HYDROPHOBINES TO INCREASE GAS TRANSFER IN AEROBE FERMENTATION PROCESSES
KR20160101073A (ko) 2013-12-20 2016-08-24 더 브로드 인스티튜트, 인코퍼레이티드 신생항원 백신과의 병용 요법
US9682123B2 (en) 2013-12-20 2017-06-20 The Trustees Of Columbia University In The City Of New York Methods of treating metabolic disease
CN105829310B (zh) 2013-12-20 2019-04-12 阿斯特克斯治疗有限公司 双环杂环化合物及其治疗用途
US9637791B2 (en) 2013-12-20 2017-05-02 Roche Molecular Systems, Inc. Multiplexed nucleic acid target identification by strucutre based probe cleavage
US9512406B2 (en) 2013-12-20 2016-12-06 The J. David Gladstone Institute, a testamentary trust established under the Will of J. David Gladstone Generating hepatocytes
US9243289B2 (en) 2013-12-23 2016-01-26 Roche Molecular Systems, Inc. Method for screening reagents used in PCR assays
EP3087394A2 (en) 2013-12-27 2016-11-02 Merrimack Pharmaceuticals, Inc. Biomarker profiles for predicting outcomes of cancer therapy with erbb3 inhibitors and/or chemotherapies
JP6608368B2 (ja) 2013-12-30 2019-11-20 アトレカ インコーポレイテッド 核酸バーコードを用いた単一細胞と関連づけられた核酸の分析方法
EP2889382A1 (en) 2013-12-30 2015-07-01 Centrum Badan DNA Sp. z o.o. Oligonucleotides, use thereof, methods and a kit for detection of DNA Borrelia burgdorferi, Bartonella henselae, Babesia divergens, Anaplasma phagocytophilum
UY35928A (es) 2013-12-31 2015-07-31 Dow Agrosciences Llc ?GEN Rf3 RESTAURADOR DE LA ANDROESTERILIDAD CITOPLASMÁTICA (CMS) TIPO S?.
EP3090063B1 (en) 2013-12-31 2019-11-06 Bio-Rad Laboratories, Inc. Method for detection of latent retrovirus
US10287591B2 (en) 2013-12-31 2019-05-14 Danisco Us Inc Enhanced protein expression
DK3447493T3 (da) 2014-01-07 2020-08-17 Bioatla Llc Proteinrettede ortologer
CN117106095A (zh) 2014-01-10 2023-11-24 比奥贝拉蒂治疗公司 因子viii嵌合蛋白及其用途
US9354175B2 (en) 2014-01-10 2016-05-31 Lucigen Corporation Lucigen yellow (LucY), a yellow fluorescent protein
CN105979770B (zh) 2014-01-15 2019-07-05 孟山都技术公司 用于使用epsps多核苷酸的杂草控制的方法和组合物
US10036077B2 (en) 2014-01-15 2018-07-31 Abbott Laboratories Covered sequence conversion DNA and detection methods
WO2015109212A1 (en) 2014-01-17 2015-07-23 Pfizer Inc. Anti-il-2 antibodies and compositions and uses thereof
US10392629B2 (en) 2014-01-17 2019-08-27 Board Of Trustees Of Michigan State University Increased caloric and nutritional content of plant biomass
US9714429B2 (en) 2014-01-28 2017-07-25 Arkansas State University Regulatory sequence of cupin family gene
CN106132992B (zh) 2014-01-29 2020-08-07 达娜-法勃肿瘤研究所公司 针对muc1-c/胞外结构域(muc1-c/ecd)的抗体
US20160340659A1 (en) 2014-01-30 2016-11-24 Yissum Research And Development Company Of The Hebrew University Of Jerusalem Ltd. Actin binding peptides and compositions comprising same for inhibiting angiogenesis and treating medical conditions associated with same
GB201401648D0 (en) 2014-01-31 2014-03-19 Dupont Nutrition Biosci Aps Protein
EP3099808A2 (en) 2014-01-31 2016-12-07 Biogen MA Inc. Methods of increasing protein production in mammalian cells
US20160333332A1 (en) 2014-01-31 2016-11-17 Danisco Us Inc. Methods for Improving By-Products from Fermentation Processes Using Xylanase
JP2017506259A (ja) 2014-02-03 2017-03-02 イッスム・リサーチ・ディベロップメント・カンパニー・オブ・ザ・ヘブルー・ユニバーシティ・オブ・エルサレム・リミテッドＹｉｓｓｕｍ Ｒｅｓｅａｒｃｈ Ｄｅｖｅｌｏｐｍｅｎｔ Ｃｏｍｐａｎｙ Ｏｆ Ｔｈｅ Ｈｅｂｒｅｗ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｊｅｒｕｓａｌｅｍ Ｌｔｄ． 幹細胞を枯渇させるためのカゼインキナーゼｉ阻害剤の使用
CA2935195A1 (en) 2014-02-03 2015-08-06 Bioasis Technologies, Inc. P97 fusion proteins
CN106103713B (zh) 2014-02-03 2021-05-28 赛默飞世尔科技波罗的海封闭股份公司 用于经控制dna片段化的方法
WO2015118537A2 (en) 2014-02-05 2015-08-13 Yeda Research And Development Co. Ltd. Micro-rnas and compositions comprising same for the treatment and diagnosis of serotonin-, adrenalin-, noradrenalin-, glutamate-, and corticotropin-releasing hormone- associated medical conditions
CN106573976B (zh) 2014-02-06 2020-05-05 耶达研究及发展有限公司 抗cd84抗体、包含所述抗体的组合物及其用途
US10287627B2 (en) 2014-02-08 2019-05-14 The Regents Of The University Of Colorado, A Body Corporate Multiplexed linking PCR
WO2015118547A1 (en) 2014-02-10 2015-08-13 Protalix Ltd. Method of maintaining disease stability in a subject having gaucher's disease
BR112016018489A2 (pt) 2014-02-11 2017-08-08 Brainstorm Cell Therapeutics Ltd Método de qualificação de células, população isolada de células-tronco mesenquimais, método de tratamento de uma doença imune ou inflamatória, e uso de células-tronco mesenquimais
CN106029962A (zh) 2014-02-11 2016-10-12 豪夫迈·罗氏有限公司 靶向测序和uid过滤
EP3105254B1 (en) 2014-02-14 2019-11-20 Symvivo Corporation Hybrid proteins and uses thereof
WO2015126729A1 (en) 2014-02-19 2015-08-27 Bioasis Technologies, Inc. P97-ids fusion proteins
CA2939580C (en) 2014-02-21 2020-07-21 Syngenta Participations Ag Genetic loci associated with increased fertility in maize
US9721061B2 (en) 2014-02-21 2017-08-01 President And Fellows Of Harvard College De novo design of allosteric proteins
ES2818823T3 (es) 2014-02-27 2021-04-14 Biogen Ma Inc Método de evaluación del riesgo de LMP
NZ630710A (en) 2014-02-27 2016-03-31 Seminis Vegetable Seeds Inc Compositions and methods for peronospora resistance in spinach
AU2015222944A1 (en) 2014-02-27 2016-09-08 Massachusetts Institute Of Technology T cell balance gene expression, compositions of matters and methods of use thereof
WO2015128836A1 (en) 2014-02-28 2015-09-03 Friedrich Miescher Institute For Biomedical Research Prediction of Preeclampsia using microRNA
WO2015132784A1 (en) 2014-03-03 2015-09-11 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Method and device for detection of pseudomonas aeruginosa
EP3114240B1 (en) 2014-03-05 2019-07-24 Adaptive Biotechnologies Corporation Methods using randomer-containing synthetic molecules
EP3736344A1 (en) 2014-03-13 2020-11-11 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US9951392B2 (en) 2014-03-14 2018-04-24 Northwestern University Substrate replenishment and byproduct removal improve yeast cell-free protein synthesis
RS65213B1 (sr) 2014-03-14 2024-03-29 Cibus Us Llc Postupci i kompozicije za povećanje efikasnosti ciljane modifikacije gena korišćenjem reparacije gena posredovane oligonukleotidima
EP3119610A4 (en) 2014-03-18 2017-12-13 APDN (B.V.I.) Inc. Encrypted optical markers for security applications
US10745825B2 (en) 2014-03-18 2020-08-18 Apdn (B.V.I.) Inc. Encrypted optical markers for security applications
US9885086B2 (en) 2014-03-20 2018-02-06 Pharmacyclics Llc Phospholipase C gamma 2 and resistance associated mutations
AU2015230933B2 (en) 2014-03-21 2020-08-13 Teva Pharmaceuticals International Gmbh Antagonist antibodies directed against calcitonin gene-related peptide and methods using same
US10072046B2 (en) 2014-03-21 2018-09-11 Nutech Ventures Non-naturally occurring porcine reproductive and respiratory syndrome virus (PRRSV) and methods of using
JO3512B1 (ar) 2014-03-26 2020-07-05 Astex Therapeutics Ltd مشتقات كينوكسالين مفيدة كمعدلات لإنزيم fgfr كيناز
MA55696A (fr) 2014-03-26 2022-02-23 Astex Therapeutics Ltd Combinaisons
US10736900B2 (en) 2014-03-26 2020-08-11 Astex Therapeutics Ltd Combinations of an FGFR inhibitor and an IGF1R inhibitor
EP3800267A1 (en) 2014-03-27 2021-04-07 Yale University Circulating micrornas as biomarkers for endometriosis
US20170136102A1 (en) 2014-03-27 2017-05-18 Umender Kumar SHARMA Phage-derived compositions for improved mycobacterial therapy
EP2923709A1 (en) 2014-03-28 2015-09-30 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Multi-component-multistage malaria vaccine
WO2015148960A1 (en) 2014-03-28 2015-10-01 The Board Of Regents Of The University Of Oklahoma Compositions comprising soluble hla/m. tuberculosis-specific ligand complexes and methods of production and use thereof
WO2015147370A1 (en) 2014-03-28 2015-10-01 Seegene, Inc. Detection of target nucleic acid sequences using different detection temperatures
EP3125936B1 (en) 2014-03-31 2019-05-08 Debiopharm International SA Fgfr fusions
WO2015153339A2 (en) 2014-04-01 2015-10-08 Monsanto Technology Llc Compositions and methods for controlling insect pests
US11390921B2 (en) 2014-04-01 2022-07-19 Adaptive Biotechnologies Corporation Determining WT-1 specific T cells and WT-1 specific T cell receptors (TCRs)
EP3126509A1 (en) 2014-04-01 2017-02-08 DuPont Nutrition Biosciences ApS Method for increasing crude palm oil yields
US10066265B2 (en) 2014-04-01 2018-09-04 Adaptive Biotechnologies Corp. Determining antigen-specific t-cells
WO2015153929A2 (en) 2014-04-02 2015-10-08 The Regents Of The University Of California A synthetic biochemistry molecular purge valve module that maintain co-factor balance
US20150322451A1 (en) 2014-04-08 2015-11-12 Altria Client Services Inc. Tobacco having altered leaf properties and methods of making and using
EP3129493B1 (en) 2014-04-09 2021-07-07 The Scripps Research Institute Import of unnatural or modified nucleoside triphosphates into cells via nucleic acid triphosphate transporters
WO2015155777A1 (en) 2014-04-10 2015-10-15 Bonus Therapeutics Ltd. Bone repair compositions
EP3643795B1 (en) 2014-04-14 2022-03-30 Yissum Research and Development Company of the Hebrew University of Jerusalem Ltd. A method for determining the death of cells or tissue by dna methylation analysis
WO2015160975A2 (en) 2014-04-16 2015-10-22 Infinity Pharmaceuticals, Inc. Combination therapies
US20150320754A1 (en) 2014-04-16 2015-11-12 Infinity Pharmaceuticals, Inc. Combination therapies
US9598678B2 (en) 2014-04-17 2017-03-21 Nutech Ventures Microbial strains and methods of making and using
ES2777529T3 (es) 2014-04-17 2020-08-05 Adaptive Biotechnologies Corp Cuantificación de genomas de células inmunitarias adaptativas en una mezcla compleja de células
US10590467B2 (en) 2014-04-17 2020-03-17 Yeda Research And Development Co. Ltd. Methods and kits for analyzing DNA binding moieties attached to DNA
WO2015164228A1 (en) 2014-04-21 2015-10-29 Cellular Dynamics International, Inc. Hepatocyte production via forward programming by combined genetic and chemical engineering
US20160053302A1 (en) 2014-04-22 2016-02-25 Roche Molecular Systems, Inc. Method for visual identification of pcr solutions for accurate reaction setup
EP3134546A4 (en) 2014-04-24 2017-12-06 Dana-Farber Cancer Institute, Inc. Tumor suppressor and oncogene biomarkers predictive of anti-immune checkpoint inhibitor response
MX366359B (es) 2014-04-27 2019-07-05 Ccam Biotherapeutics Ltd Anticuerpos humanizados contra la molecula de adhesion celular relacionada al antigeno carcinoembrionico 1 (ceacam1).
WO2015166492A2 (en) 2014-04-28 2015-11-05 Yeda Research And Development Co. Ltd. Microbiome response to agents
EP3137616B1 (en) 2014-05-01 2023-05-31 Ginkgo Bioworks, Inc. Increasing cellular lipid production by increasingthe activity of diacylglycerol acyltransferase and decreasing the activity of triacylglycerol lipase
CN106413757B (zh) 2014-05-01 2022-01-14 比奥阿赛斯技术有限公司 p97-多核苷酸结合物
MX2016014128A (es) 2014-05-04 2017-05-23 Forrest Innovations Ltd Composiciones y procedimientos para recudir el enverdecimiento de los citricos inducido por patogenos.
WO2015172083A1 (en) 2014-05-08 2015-11-12 Biogen Ma Inc. Dimethylfumarate and prodrugs for treatment of multiple sclerosis
MX2016014558A (es) 2014-05-09 2018-03-12 Biosearch Tech Inc Extinguidores de fluorescencia "cosmic quenchers".
WO2015175576A2 (en) 2014-05-12 2015-11-19 The Board Of Trustees Of The University Of Illinois Higher performance proteases for scarless tag removal
US11053548B2 (en) 2014-05-12 2021-07-06 Good Start Genetics, Inc. Methods for detecting aneuploidy
EP3143399A1 (en) 2014-05-12 2017-03-22 Biogen MA Inc. Biomarkers predictive of lupus progression and uses thereof
EP3143166A4 (en) 2014-05-16 2018-04-18 University of Massachusetts Treating chronic myelogenous leukemia (cml)
US20150329898A1 (en) 2014-05-19 2015-11-19 Amplicon Express Mate-Pair Sequences from Large Inserts
WO2015177800A2 (en) 2014-05-22 2015-11-26 Yeda Research And Development Co. Ltd. Recombinant microorganisms capable of carbon fixation
WO2015183837A1 (en) 2014-05-27 2015-12-03 Brian Haynes Compositions, methods, and uses related to ntrk2-tert fusions
WO2015183836A1 (en) 2014-05-27 2015-12-03 Brian Haynes Compositions, methods, and uses related to ntrk2-tert fusions
US10041120B2 (en) 2014-05-28 2018-08-07 Scripps Health Predictive analysis for myocardial infarction
WO2015184303A1 (en) 2014-05-29 2015-12-03 Novogy, Inc. Increasing lipid production in oleaginous yeast
CN108064268A (zh) 2014-05-29 2018-05-22 诺沃吉公司 增加脂质产生和优化脂质组成
EP3149155B1 (en) 2014-06-02 2020-09-23 Kadimastem Ltd. Methods of inducing myelination and maturation of oligodendrocytes
US9670537B2 (en) 2014-06-06 2017-06-06 Titan Collaborative Kithe, Llc Borrelia Provocation Procedure kit
US10760109B2 (en) 2014-06-06 2020-09-01 The Regents Of The University Of Michigan Compositions and methods for characterizing and diagnosing periodontal disease
EP3942931A1 (en) 2014-06-10 2022-01-26 Biomatrica, INC. Stabilization of thrombocytes at ambient temperatures
US20160000936A1 (en) 2014-06-10 2016-01-07 Abbvie Inc. Biomarkers for inflammatory disease and methods of using same
JP6997619B2 (ja) 2014-06-11 2022-01-17 キャシー・エイ・グリーン 液性免疫の抑制または増進のための、ｖｉｓｔａアゴニスト及びｖｉｓｔａアンタゴニストの使用
WO2015191916A1 (en) 2014-06-11 2015-12-17 Micronics, Inc. Microfluidic cartridges and apparatus with integrated assay controls for analysis of nucleic acids
TWI695011B (zh) 2014-06-18 2020-06-01 美商梅爾莎納醫療公司 抗ｈｅｒ２表位之單株抗體及其使用之方法
WO2015198202A1 (en) 2014-06-23 2015-12-30 Friedrich Miescher Institute For Biomedical Research Methods for triggering de novo formation of heterochromatin and or epigenetic silencing with small rnas
WO2015200541A1 (en) 2014-06-24 2015-12-30 Bio-Rad Laboratories, Inc. Digital pcr barcoding
US9371546B2 (en) 2014-06-24 2016-06-21 E I Du Pont De Nemours And Company Enhancing D-xylose and L-arabinose utilization in Zymomonas cells
EP3161138A4 (en) 2014-06-25 2017-12-06 Monsanto Technology LLC Methods and compositions for delivering nucleic acids to plant cells and regulating gene expression
SG11201610630RA (en) 2014-06-25 2017-01-27 Tel Hashomer Medical Res Infrastructure & Services Ltd Identification of cancer stem cell markers and use of same for diagnosis and treatment
US10640833B2 (en) 2014-06-26 2020-05-05 University Of Florida Research Foundation, Inc. Rapid detection of infectious agents
US10583084B2 (en) 2014-06-26 2020-03-10 Ramot At Tel-Aviv University Ltd. Liposomal formulations for delivery of nucleic acids
US10316369B2 (en) 2014-06-27 2019-06-11 Seminis Vegetable Seeds, Inc. Methods and assays for male sterile watermelon
EP3160478A4 (en) 2014-06-30 2018-05-16 Bioverativ Therapeutics Inc. Optimized factor ix gene
US9737598B2 (en) 2014-06-30 2017-08-22 Regents Of The University Of Minnesota CD200 inhibitors and methods of use thereof
WO2016007632A1 (en) 2014-07-08 2016-01-14 Altria Client Services Llc The genetic locus imparting a low anatabine trait in tobacco and methods of using
WO2016005985A2 (en) 2014-07-09 2016-01-14 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Method for reprogramming cells
CN107001442B (zh) 2014-07-15 2021-04-27 耶路撒冷希伯来大学伊森姆研究发展公司 Cd44的分离的多肽及其应用
EP3169310A1 (en) 2014-07-15 2017-05-24 Life Technologies Corporation Compositions with lipid aggregates and methods for efficient delivery of molecules to cells
EP3169793B1 (en) 2014-07-16 2022-07-06 Tangen Biosciences Inc. Isothermal methods for amplifying nucleic acid samples
US9968579B2 (en) 2014-07-17 2018-05-15 Beth Isreal Deaconess Medical Center, Inc. ATRA for modulating Pin1 activity and stability
US10351914B2 (en) 2014-07-17 2019-07-16 Beth Israel Deaconess Medical Center, Inc. Biomarkers for Pin1-associated disorders
JP2017528430A (ja) 2014-07-17 2017-09-28 ブライアン ジェイ ツェルニキＣＺＥＲＮＩＥＣＫＩ， Ｂｒｉａｎ， Ｊ． 免疫に基づく療法のための、免疫原性ｍｈｃクラスｉｉペプチドの同定
CA2955414A1 (en) 2014-07-21 2016-01-28 Novellusdx Ltd. Methods and systems for determining oncogenic index of patient specific mutations
CA2955411A1 (en) 2014-07-21 2016-01-28 Novellusdx Ltd. Methods for determining drug response of patient specific mutations
WO2016014493A1 (en) 2014-07-22 2016-01-28 Bio-Rad Laboratories, Inc. Buffers for use with polymerases
CN107087416A (zh) 2014-07-24 2017-08-22 泰拉瑞亚控股公司 变体硫酯酶及使用方法
US10378012B2 (en) 2014-07-29 2019-08-13 Monsanto Technology Llc Compositions and methods for controlling insect pests
CN108064274A (zh) 2014-07-30 2018-05-22 耶达研究及发展有限公司 用于培养多能干细胞的培养基
US20170224777A1 (en) 2014-08-12 2017-08-10 Massachusetts Institute Of Technology Synergistic tumor treatment with il-2, a therapeutic antibody, and a cancer vaccine
CN111624346A (zh) 2014-08-14 2020-09-04 米密德诊断学有限公司 用于预测及/或决定预后的套组
ES2644949T3 (es) 2014-08-28 2017-12-01 F. Hoffmann-La Roche Ag Oligonucleótidos para controlar la amplificación de ácidos nucleicos
WO2016030899A1 (en) 2014-08-28 2016-03-03 Yeda Research And Development Co. Ltd. Methods of treating amyotrophic lateral scleroses
US10118950B2 (en) 2014-08-30 2018-11-06 Northwestern University Platforms for cell-free protein synthesis comprising extracts from genomically recoded E. coli strains having genetic knock-out mutations in release factor 1 (RF-1) and endA
MX2017002805A (es) 2014-09-03 2017-12-20 Bioatla Llc Descubrimiento y producción de proteínas biológicas condicionalmente activas en las mismas células hospederas eucariotas de producción.
CA2959716A1 (en) 2014-09-08 2016-03-17 Yeda Research And Development Co. Ltd. Anti-her3 antibodies and uses of same
EP2992895A1 (en) 2014-09-08 2016-03-09 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Three-component-multistage malaria vaccine
EP3191523B1 (en) 2014-09-08 2019-08-07 Yeda Research and Development Co., Ltd. Compositions and methods for treating cancer resistant to a tyrosine kinase inhibitor (tki)
JP2017532024A (ja) 2014-09-09 2017-11-02 ザ・ブロード・インスティテュート・インコーポレイテッド コンポジット単一細胞核酸分析のための液滴ベースの方法および機器
CA2960821A1 (en) 2014-09-09 2016-03-17 Igenomx International Genomics Corporation Methods and compositions for rapid nucleic acid library preparation
WO2016040446A1 (en) 2014-09-10 2016-03-17 Good Start Genetics, Inc. Methods for selectively suppressing non-target sequences
CA2960642A1 (en) 2014-09-10 2016-03-17 Georgetown University Compositions and methods of using interleukin-4 induced gene 1 (il4i1)
WO2016040843A1 (en) 2014-09-11 2016-03-17 Harry Stylli Methods of detecting prostate cancer
EP3191591A1 (en) 2014-09-12 2017-07-19 Alnylam Pharmaceuticals, Inc. Polynucleotide agents targeting complement component c5 and methods of use thereof
IL234638A0 (en) 2014-09-14 2014-12-02 Yeda Res & Dev NMDA receptor antagonists for the treatment of Gaucher disease
KR102541849B1 (ko) 2014-09-15 2023-06-09 에이비비트로, 엘엘씨 고-처리량 뉴클레오티드 라이브러리 서열결정
AU2015317692A1 (en) 2014-09-17 2017-04-06 Hologic, Inc. Method of partial lysis and assay
WO2016044779A2 (en) 2014-09-18 2016-03-24 Solazyme, Inc. Acyl-acp thioesterases and mutants thereof
WO2016042561A2 (en) 2014-09-21 2016-03-24 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Downregulating mir-132 for the treatment of lipid related disorders
EP3224595A4 (en) 2014-09-24 2018-06-13 Good Start Genetics, Inc. Process control for increased robustness of genetic assays
SG10201902594QA (en) 2014-09-24 2019-04-29 Aileron Therapeutics Inc Peptidomimetic macrocycles and uses thereof
US20170281683A1 (en) 2014-09-26 2017-10-05 Baylor College Of Medicine Glypican-3 specific chimeric antigen receptors for adoptive immunotherapy
US20170247756A1 (en) 2014-10-03 2017-08-31 Life Technologies Corporation Genetic sequence verification compositions, methods and kits
EP3204501B1 (en) 2014-10-06 2019-01-09 Altria Client Services LLC Genetic control of axillary bud growth in tobacco plants
CA2963091A1 (en) 2014-10-06 2016-04-14 Dana-Farber Cancer Institute, Inc. Angiopoietin-2 biomarkers predictive of anti-immune checkpoint response
US10774388B2 (en) 2014-10-08 2020-09-15 Novartis Ag Biomarkers predictive of therapeutic responsiveness to chimeric antigen receptor therapy and uses thereof
JP6941561B2 (ja) 2014-10-09 2021-09-29 デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド 免疫障害を処置するための複数の可変ｉｌ−２用量レジメン
EP3005862A1 (en) 2014-10-10 2016-04-13 Seminis Vegetable Seeds, Inc. Melon plants with improved disease tolerance
JOP20200115A1 (ar) 2014-10-10 2017-06-16 Alnylam Pharmaceuticals Inc تركيبات وطرق لتثبيط التعبير الجيني عن hao1 (حمض أوكسيداز هيدروكسيلي 1 (أوكسيداز جليكولات))
WO2016060974A1 (en) 2014-10-13 2016-04-21 Life Technologies Corporation Methods, systems, and computer-readable media for accelerated base calling
EP3207160B1 (en) 2014-10-14 2019-11-20 Abbott Laboratories Sequence conversion and signal amplifier dna having locked nucleic acids and detection methods using same
WO2016061487A1 (en) 2014-10-17 2016-04-21 Alnylam Pharmaceuticals, Inc. Polynucleotide agents targeting aminolevulinic acid synthase-1 (alas1) and uses thereof
DE102015220401B4 (de) 2014-10-20 2022-12-29 Gen-Probe Incorporated Erythrozyten-Lyselösung
US10704104B2 (en) 2014-10-20 2020-07-07 Inserm (Institut National De La Sante Et De La Recherche Medicale) Methods for screening a subject for a cancer
EP3172329A1 (en) 2014-10-24 2017-05-31 Danisco US Inc. Method for producing alcohol by use of a tripeptidyl peptidase
DK3209773T3 (da) 2014-10-24 2020-06-15 Dupont Nutrition Biosci Aps Prolintolerante tripeptidylpeptidaser og anvendelser deraf
EP3212790B1 (en) 2014-10-29 2020-03-25 Adaptive Biotechnologies Corp. Highly-multiplexed simultaneous detection of nucleic acids encoding paired adaptive immune receptor heterodimers from many samples
EP4026913A1 (en) 2014-10-30 2022-07-13 Personalis, Inc. Methods for using mosaicism in nucleic acids sampled distal to their origin
WO2016069694A2 (en) 2014-10-30 2016-05-06 Alnylam Pharmaceuticals, Inc. Polynucleotide agents targeting serpinc1 (at3) and methods of use thereof
US10000799B2 (en) 2014-11-04 2018-06-19 Boreal Genomics, Inc. Methods of sequencing with linked fragments
US10034868B2 (en) 2014-11-04 2018-07-31 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for the prevention and the treatment of rapidly progressive glomerulonephritis
WO2016070945A1 (de) 2014-11-07 2016-05-12 Gna Biosolutions Gmbh Pcr-verfahren zur superamplifikation
WO2016074701A1 (de) 2014-11-10 2016-05-19 Gna Biosolutions Gmbh Verfahren zum vervielfältigen von nukleinsäuren
US20180340174A1 (en) 2014-11-11 2018-11-29 Nanocore Aps Method for identification of molecules with desired characteristics
US9926375B2 (en) 2014-11-12 2018-03-27 Tracon Pharmaceuticals, Inc. Anti-endoglin antibodies and uses thereof
JP2017537084A (ja) 2014-11-12 2017-12-14 トラコン ファーマシューティカルズ、インコーポレイテッド 抗エンドグリン抗体及びその用途
AU2015346969B2 (en) 2014-11-13 2019-03-21 Enzootic Holdings Ltd. Functional sex-reversal of decapod crustacean females
WO2016075305A2 (en) 2014-11-13 2016-05-19 Evaxion Biotech Aps Peptides derived from acinetobacter baumannii and their use in vaccination
US10246701B2 (en) 2014-11-14 2019-04-02 Adaptive Biotechnologies Corp. Multiplexed digital quantitation of rearranged lymphoid receptors in a complex mixture
JP7067926B2 (ja) 2014-11-14 2022-05-16 ビーエーエスエフ プラント サイエンス カンパニー ゲーエムベーハー 種子油においてトコフェロール含量を増加させるための材料および方法
WO2016079736A2 (en) 2014-11-17 2016-05-26 Yeda Research And Development Co. Ltd. Methods of treating diseases related to mitochondrial function
CA2968221A1 (en) 2014-11-17 2016-05-26 Boston Heart Diagnostic Corporation Cardiovascular disease risk assessment
CA2967233A1 (en) 2014-11-17 2016-05-26 Yeda Research And Development Co. Ltd. Method of analyzing microbiome
JP6857603B2 (ja) 2014-11-18 2021-04-14 ヤンセン ファーマシューティカ エヌ．ベー． 抗ｃｄ１４７抗体、方法及び使用
AU2015349782B2 (en) 2014-11-20 2020-08-13 Cytonics Corporation Therapeutic variant alpha-2-macroglobulin compositions
EP3221455B1 (en) 2014-11-20 2020-08-12 Yissum Research and Development Company of the Hebrew University of Jerusalem Ltd. Compositions and methods for producing polypeptides with a modified glycosylation pattern in plant cells
US10889631B2 (en) 2014-11-20 2021-01-12 Cytonics Corporation Therapeutic variant alpha-2-macroglobulin compositions
EP3224359B1 (en) 2014-11-25 2023-10-25 Bio-Rad Laboratories, Inc. Arginine improves polymerase storage stability
WO2016086227A2 (en) 2014-11-26 2016-06-02 The Regents Of The University Of California Therapeutic compositions comprising transcription factors and methods of making and using the same
CN107208070B (zh) 2014-11-26 2021-09-07 技术创新动力基金（以色列）有限合伙公司 细菌基因的靶向消除
CA2968065C (en) 2014-11-26 2024-04-09 Jau-Nan Lee Induced hepatocytes and uses thereof
CA2968808A1 (en) 2014-11-27 2016-06-02 Danziger Innovations Ltd. Nucleic acid constructs for genome editing
US10077420B2 (en) 2014-12-02 2018-09-18 Histogenics Corporation Cell and tissue culture container
US9920381B2 (en) 2014-12-02 2018-03-20 Roche Molecular Systems, Inc. Compositions and methods for detecting MECC-containing methicillin-resistant Staphylococcus aureus
AU2015357463B2 (en) 2014-12-05 2021-10-07 Immunext, Inc. Identification of VSIG8 as the putative vista receptor and its use thereof to produce vista/VSIG8 modulators
EP3227687A4 (en) 2014-12-05 2018-10-24 Prelude, Inc. Dcis recurrence and invasive breast cancer
US11220545B2 (en) 2014-12-08 2022-01-11 Dana-Farber Cancer Institute, Inc. Methods for upregulating immune responses using combinations of anti-RGMb and anti-PD-1 agents
TWI595006B (zh) 2014-12-09 2017-08-11 禮納特神經系統科學公司 抗ｐｄ－１抗體類和使用彼等之方法
WO2016092555A2 (en) 2014-12-11 2016-06-16 Yeda Research And Development Co. Ltd. Isolated phosphotriesterase polypeptides, polynucleotides encoding same and uses thereof in treating or preventing organophosphate exposure associated damage
WO2016093838A1 (en) 2014-12-11 2016-06-16 New England Biolabs, Inc. Enrichment of target sequences
EP3604556A1 (en) 2014-12-12 2020-02-05 Medivation Prostate Therapeutics LLC Method for predicting response to breast cancer therapeutic agents and method of treatment of breast cancer
CN113981057A (zh) 2014-12-12 2022-01-28 精密科学公司 用于进行甲基化检测测定的组合物和方法
JP7012533B2 (ja) 2014-12-16 2022-02-14 ダニスコ・ユーエス・インク タンパク質発現の増強
US9909169B2 (en) 2014-12-17 2018-03-06 Roche Molecular Systems, Inc. Allele-specific amplification of nucleic acids using blocking oligonucleotides for wild type suppression
JP2017538433A (ja) 2014-12-19 2017-12-28 ダニスコ・ユーエス・インク タンパク質の発現増大
US10993997B2 (en) 2014-12-19 2021-05-04 The Broad Institute, Inc. Methods for profiling the t cell repertoire
CN108064251A (zh) 2014-12-19 2018-05-22 达纳－法伯癌症研究所公司 碳酸酐酶ix特异性嵌合抗原受体及其使用方法
US10975442B2 (en) 2014-12-19 2021-04-13 Massachusetts Institute Of Technology Molecular biomarkers for cancer immunotherapy
WO2016106387A2 (en) 2014-12-22 2016-06-30 University Of Iowa Research Foundation Nucleic acid aptamers to treat histone-induced disease states
WO2016103269A1 (en) 2014-12-23 2016-06-30 Ramot At Tel-Aviv University Ltd. Populations of neural progenitor cells and methods of producing and using same
EP3778644A3 (en) 2014-12-23 2021-06-02 The Trustees of Columbia University in the City of New York Fgfr-tacc fusion proteins and methods thereof
PT3065748T (pt) 2014-12-23 2018-02-28 4D Pharma Res Ltd Uma estirpe de bacteroides thetaiotaomicron e o seu uso na redução da inflamação
MX2017008449A (es) 2014-12-23 2017-10-12 4D Pharma Res Ltd Polipeptido de pirina y modulacion inmune.
WO2016103234A1 (en) 2014-12-24 2016-06-30 Abbott Japan Co., Ltd. Detection method based on signal amplifier dna cascade reactions with target extension
ES2880346T3 (es) 2014-12-30 2021-11-24 Cell Cure Neurosciences Ltd Evaluación de poblaciones de células epiteliales de pigmento retiniano
ES2774456T3 (es) 2014-12-30 2020-07-21 Cell Cure Neurosciences Ltd Poblaciones de células del RPE y métodos de generación de las mismas
MX2017008553A (es) 2014-12-30 2018-03-14 Telomere Diagnostics Inc Pcr cuantitativa multiple.
WO2016108244A1 (en) 2015-01-04 2016-07-07 Protalix Ltd. Modified dnase and uses thereof
EP3271480B8 (en) 2015-01-06 2022-09-28 Molecular Loop Biosciences, Inc. Screening for structural variants
JP6944873B2 (ja) 2015-01-09 2021-10-06 ジェン−プローブ・インコーポレーテッド 細菌性膣症を診断するための方法および組成物
EP4279080A3 (en) 2015-01-12 2024-02-21 Evaxion Biotech A/S Treatment and prophylaxis of k. pneumoniae infection
MA41346A (fr) 2015-01-12 2017-11-21 Juno Therapeutics Inc Eléments régulateurs post-transcriptionnels d'hépatite modifiée
US9984201B2 (en) 2015-01-18 2018-05-29 Youhealth Biotech, Limited Method and system for determining cancer status
KR101718800B1 (ko) 2015-01-21 2017-03-24 주식회사 디알나노 약물 및 ｓｉＲＮＡ의 공동―운반용 나노복합체 및 이의 용도
WO2016116935A1 (en) 2015-01-21 2016-07-28 Yeda Research And Development Co. Ltd. Use of rasa2 as a prognostic and therapeutic marker for melanoma
JP6942632B2 (ja) 2015-01-22 2021-09-29 モンサント テクノロジー エルエルシー Ｌｅｐｔｉｎｏｔａｒｓａ防除用組成物及びその方法
EP3247988A4 (en) 2015-01-23 2018-12-19 Vanderbilt University A robust interferometer and methods of using same
US20180112180A1 (en) 2015-01-26 2018-04-26 Fate Therapeutics, Inc. Cells with increased immuno-regulatory properties and methods for their use and manufacture
US20180002656A1 (en) 2015-01-28 2018-01-04 Sabic Global Technologies B.V. Methods and compositions for high-efficiency production of biofuel and/or biomass
US10555467B2 (en) 2015-01-29 2020-02-11 Pioneer Hi-Bred International, Inc. Polynucleotides and kits associated with soybean iron deficiency tolerance and methods of detection and breeding
EP3253793A4 (en) 2015-02-02 2018-11-14 i2 Pharmaceuticals, Inc. Anti-surrogate light chain antibodies
EP3253867B1 (en) 2015-02-02 2020-05-06 H. Hoffnabb-La Roche Ag Polymerase variants
GB201501941D0 (en) 2015-02-05 2015-03-25 British American Tobacco Co Method
AU2016219511B2 (en) 2015-02-09 2020-11-12 Research Development Foundation Engineered immunoglobulin Fc polypeptides displaying improved complement activation
JOP20200201A1 (ar) 2015-02-10 2017-06-16 Astex Therapeutics Ltd تركيبات صيدلانية تشتمل على n-(3.5- ثنائي ميثوكسي فينيل)-n'-(1-ميثيل إيثيل)-n-[3-(ميثيل-1h-بيرازول-4-يل) كينوكسالين-6-يل]إيثان-1.2-ثنائي الأمين
US10421993B2 (en) 2015-02-11 2019-09-24 Paragon Genomics, Inc. Methods and compositions for reducing non-specific amplification products
AU2016219263B2 (en) 2015-02-13 2022-12-01 Alnylam Pharmaceuticals, Inc. Patatin-like phospholipase domain containing 3 (PNPLA3) iRNA compositions and methods of use thereof
WO2016134059A1 (en) 2015-02-17 2016-08-25 Bio-Rad Laboratories, Inc. Small nucleic acid quantification using split cycle amplification
EP3259358A2 (en) 2015-02-19 2017-12-27 Danisco US Inc. Enhanced protein expression
US10208339B2 (en) 2015-02-19 2019-02-19 Takara Bio Usa, Inc. Systems and methods for whole genome amplification
JP6620160B2 (ja) 2015-02-20 2019-12-11 タカラ バイオ ユーエスエー， インコーポレイテッド 単一細胞の迅速かつ正確な分注、視覚化及び解析のための方法
EP3259346A4 (en) 2015-02-20 2018-07-11 Baylor College of Medicine P63 inactivation for the treatment of heart failure
EP3262193A2 (en) 2015-02-26 2018-01-03 The Broad Institute Inc. T cell balance gene expression, compositions of matters and methods of use thereof
EP3261612A1 (en) 2015-02-26 2018-01-03 Yeda Research and Development Co. Ltd Method of promoting hair growth
US20180071280A1 (en) 2015-02-26 2018-03-15 Urifer Ltd. Modulators of cell death processes
US10948492B2 (en) 2015-03-06 2021-03-16 Dana-Farber Cancer Institute, Inc. PD-L2 biomarkers predictive of PD-1 pathway inhibitor responses in esophagogastric cancers
WO2016145128A1 (en) 2015-03-09 2016-09-15 Caris Science, Inc. Oligonucleotide probes and uses thereof
EP3268462B1 (en) 2015-03-11 2021-08-11 The Broad Institute, Inc. Genotype and phenotype coupling
US10548864B2 (en) 2015-03-12 2020-02-04 Beth Israel Deaconess Medical Center, Inc. Enhanced ATRA-related compounds for the treatment of proliferative diseases, autoimmune diseases, and addiction conditions
MX2017011648A (es) 2015-03-12 2017-11-02 Zoetis Services Llc Metodos de piolisina y composiciones.
CN107429296B (zh) 2015-03-13 2022-01-28 生命技术公司 捕获、检测和定量小rna的方法、组合物与试剂盒
JP6796593B2 (ja) 2015-03-16 2020-12-09 ジェン−プローブ・インコーポレーテッド 細菌核酸を検出し細菌性膣炎を診断するための方法および組成物
EP3271848A4 (en) 2015-03-16 2018-12-05 Personal Genome Diagnostics Inc. Systems and methods for analyzing nucleic acid
US10066256B2 (en) 2015-03-17 2018-09-04 Bio-Rad Laboratories, Inc. Detection of genome editing
IL237852A0 (en) 2015-03-19 2016-03-24 Yeda Res & Dev Antibodies against amphigoline, medical preparations containing them and their use
AU2016235424A1 (en) 2015-03-20 2017-10-05 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
WO2016154046A2 (en) 2015-03-20 2016-09-29 Verdezyne, Inc. Biological methods for preparing 3-hydroxypropionic acid
US9708647B2 (en) 2015-03-23 2017-07-18 Insilixa, Inc. Multiplexed analysis of nucleic acid hybridization thermodynamics using integrated arrays
US20180064748A1 (en) 2015-03-27 2018-03-08 Yeda Research And Development Co. Ltd. Methods of treating motor neuron diseases
TW202336236A (zh) 2015-03-27 2023-09-16 美商再生元醫藥公司 偵測生物污染物之組成物及方法
WO2016161273A1 (en) 2015-04-01 2016-10-06 Adaptive Biotechnologies Corp. Method of identifying human compatible t cell receptors specific for an antigenic target
EP3277260B1 (en) 2015-04-01 2021-05-12 The State of Israel, Ministry of Agriculture & Rural Development, Agricultural Research Organization (ARO) (Volcani Center) Erodium crassifolium l'her plant extracts and uses thereof
US10478494B2 (en) 2015-04-03 2019-11-19 Astex Therapeutics Ltd FGFR/PD-1 combination therapy for the treatment of cancer
EP3280821B1 (en) 2015-04-07 2023-12-06 Polyskope Labs Detection of one or more pathogens
EP3280401B1 (en) 2015-04-07 2021-08-25 ELA Pharma Ltd Compositions for treating and/or preventing cell or tissue necrosis specifically targeting cathepsin c and/or cela1 and/or cela3a and/or structurally related enzymes thereto
WO2016162325A1 (en) 2015-04-07 2016-10-13 Astrazeneca Ab Substituted 3,4-dihydropyrrolo[1,2-a]pyrazin-1 (2h)-one derivatives as kinase inhibitors
WO2016164746A1 (en) 2015-04-08 2016-10-13 Alnylam Pharmaceuticals, Inc. Compositions and methods for inhibiting expression of the lect2 gene
EP4321627A3 (en) 2015-04-10 2024-04-17 10x Genomics Sweden AB Spatially distinguished, multiplex nucleic acid analysis of biological specimens
EP3081575A1 (en) 2015-04-12 2016-10-19 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Anti-plasmodium parasite antibodies
MY188432A (en) 2015-04-13 2021-12-08 Pfizer Chimeric antigen receptors targeting b-cell maturation antigen
SI3283106T1 (sl) 2015-04-13 2022-04-29 Pfizer Inc. Terapevtska protitelesa in njihova uporaba
CN107922454B (zh) 2015-04-15 2021-10-22 生物检索技术股份有限公司 双猝灭剂探针
BR112017022329A2 (pt) 2015-04-17 2018-07-17 Univ California métodos para detectar aglutinação e composições para uso na prática do mesmo
WO2016172606A1 (en) 2015-04-23 2016-10-27 Baylor College Of Medicine Cd5 chimeric antigen receptor for adoptive t cell therapy
WO2016170447A1 (en) 2015-04-24 2016-10-27 Rinat Neuroscience Corp. Recombinant microbial transglutaminases
EP3286338B1 (en) 2015-04-24 2023-11-01 Atila Biosystems Incorporated Amplification with primers of limited nucleotide composition
KR102565860B1 (ko) 2015-04-24 2023-08-11 벡톤 디킨슨 앤드 컴퍼니 외음질 칸디다증, 질편모충증 및 세균성 질염의 복합 검출 방법
WO2016174674A1 (en) 2015-04-27 2016-11-03 The Medical Research, Infrastructure and Health Services Fund of the Tel Aviv Medical Center Egr1 targeting molecules for the treatment of inflammatory and hyperproliferative conditions
US10844428B2 (en) 2015-04-28 2020-11-24 Illumina, Inc. Error suppression in sequenced DNA fragments using redundant reads with unique molecular indices (UMIS)
EP3289074B1 (en) 2015-04-28 2023-10-04 Université de Strasbourg Clinical gene signature-based human cell culture model and uses thereof
CN108347945B (zh) 2015-04-29 2021-03-23 以色列农业和农村发展部农业研究组织(范卡尼中心) 抗植物致病组合物
US20190031759A1 (en) 2015-04-30 2019-01-31 Technion Research & Development Foundation Limited Chimeric antigen receptors and methods of their use
WO2016178207A1 (en) 2015-05-04 2016-11-10 Ramot At Tel-Aviv University Ltd. Methods and kits for fragmenting dna
DK3291841T3 (da) 2015-05-04 2022-01-10 Brigham & Womens Hospital Inc Onkolytisk hsv1-vektor og fremgangsmåder
EP3294280A1 (en) 2015-05-11 2018-03-21 Yeda Research and Development Co., Ltd. Citrin inhibitors for the treatment of cancer
NZ737094A (en) 2015-05-11 2019-06-28 Impossible Foods Inc Expression constructs and methods of genetically engineering methylotrophic yeast
EP3295345B1 (en) 2015-05-14 2023-01-25 Life Technologies Corporation Barcode sequences, and related systems and methods
US10526588B2 (en) 2015-05-14 2020-01-07 Roche Sequencing Solutions, Inc. Polymerase variants and uses thereof
EP3294448A4 (en) 2015-05-14 2018-12-12 Longhorn Vaccines and Diagnostics, LLC Rapid methods for the extraction of nucleic acids from biological samples
EP3298141A4 (en) 2015-05-17 2019-01-09 The Medical Research, Infrastructure, And Health Services Fund Of The Tel Aviv Medical Center COMPOSITIONS AND METHOD FOR THE TREATMENT OF CANCER
JP2018516594A (ja) 2015-05-18 2018-06-28 カリミューン， インコーポレーティッド Ｈｉｖ−１とレンチウイルスベクターとを識別する方法
WO2016185457A1 (en) 2015-05-19 2016-11-24 Yeda Research And Development Co. Ltd. Methods of promoting lymphangiogenesis
WO2016185481A2 (en) 2015-05-20 2016-11-24 Yeda Research And Development Co. Ltd. Method of targeting senescent cells
MY190974A (en) 2015-05-20 2022-05-25 Massachusetts Gen Hospital Shared neoantigens
WO2016185469A1 (en) 2015-05-21 2016-11-24 Yeda Research And Development Co. Ltd. Bacterial populations for promoting health
US10275567B2 (en) 2015-05-22 2019-04-30 Seven Bridges Genomics Inc. Systems and methods for haplotyping
EP3302571B1 (en) 2015-05-29 2020-11-18 OPKO Biologics Ltd. Pegylated oxyntomodulin variants
WO2016196366A1 (en) 2015-05-29 2016-12-08 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Extension of replicative lifespan in diseases of premature aging using p53 isoforms
EP3302053B1 (en) 2015-06-02 2021-03-17 Monsanto Technology LLC Compositions and methods for delivery of a polynucleotide into a plant
EP3302030A4 (en) 2015-06-03 2019-04-24 Monsanto Technology LLC METHODS AND COMPOSITIONS FOR THE INTRODUCTION OF NUCLEIC ACIDS IN PLANTS
WO2016197133A1 (en) 2015-06-04 2016-12-08 Protiva Biotherapeutics, Inc. Delivering crispr therapeutics with lipid nanoparticles
WO2016197132A1 (en) 2015-06-04 2016-12-08 Protiva Biotherapeutics Inc. Treating hepatitis b virus infection using crispr
BR112017026243A2 (pt) 2015-06-05 2018-09-18 International Rice Res Institute aumento da produção de sementes híbridas através da taxa de cruzamento aberto mais alta em arroz macho estéril citoplasmático e materiais e métodos relacionados
NL2014935B1 (en) 2015-06-08 2017-02-03 Applied Immune Tech Ltd T cell receptor like antibodies having fine specificity.
WO2016201142A1 (en) 2015-06-09 2016-12-15 Life Technologies Corporation Methods, systems, compositions, kits, apparatus and computer-readable media for molecular tagging
WO2016201301A1 (en) 2015-06-12 2016-12-15 Alnylam Pharmaceuticals, Inc. Complement component c5 irna compositions and methods of use thereof
MA41010B1 (fr) 2015-06-15 2020-01-31 4D Pharma Res Ltd Compositions comprenant des souches bactériennes
LT3360559T (lt) 2015-06-15 2019-12-27 4D Pharma Research Limited Kompozicijos, apimančios bakterijų kamienus
SI3240554T1 (sl) 2015-06-15 2019-12-31 4D Pharma Research Limited, Blautia stercosis in wexlerae za uporabo v zdravljenju vnetnih in avtoimunskih bolezni
TWI733676B (zh) 2015-06-15 2021-07-21 英商4D製藥研究有限公司 包含細菌菌株之組合物
EP3310918B1 (en) 2015-06-18 2020-08-05 Alnylam Pharmaceuticals, Inc. Polynucleotide agents targeting hydroxyacid oxidase (glycolate oxidase, hao1) and methods of use thereof
WO2016203476A1 (en) 2015-06-18 2016-12-22 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Methods and compositions for diagnosing and treating urothelial cancer
ES2917884T3 (es) 2015-06-18 2022-07-12 Yeda Res & Dev Protocolos de acondicionamiento y uso de los mismos para la regeneración de tejidos
WO2016205723A2 (en) 2015-06-19 2016-12-22 Sera Prognostics, Inc. Biomarker pairs for predicting preterm birth
KR102172937B1 (ko) 2015-06-19 2020-11-03 옵코 바이오로직스 리미티드 장기-작용성 응고 인자 및 그의 제조 방법
US11473073B2 (en) 2015-06-26 2022-10-18 Dupont Nutrition Biosciences Aps Aminopeptidases for protein hydrolyzates
US10590425B2 (en) 2015-06-29 2020-03-17 Caris Science, Inc. Therapeutic oligonucleotides
US11040094B2 (en) 2015-07-01 2021-06-22 Colleen M. O'Connor Compositions and methods for treating immunological dysfunction
EP4116316A1 (en) 2015-07-04 2023-01-11 Evaxion Biotech A/S Proteins and nucleic acids useful in vaccines targeting pseudomonas aeruginosa
WO2017011275A1 (en) 2015-07-10 2017-01-19 Nersissian Aram M Factor viii protein compositions and methods of treating hemophilia a
US10494632B2 (en) 2015-07-10 2019-12-03 Alnylam Pharmaceuticals, Inc. Insulin-like growth factor binding protein, acid labile subunit (IGFALS) compositions and methods of use thereof
US10682390B2 (en) 2015-07-16 2020-06-16 Biokine Therapeutics Ltd. Compositions and methods for treating cancer
CN114457039A (zh) 2015-07-16 2022-05-10 耶达研究及发展有限公司 基因修饰的抗第三方中央型记忆t细胞及其在免疫疗法中的用途
US10668094B2 (en) 2015-07-19 2020-06-02 Yeda Research And Development Co. Ltd. Selective inhibitors of Alpha2-containing isoforms of Na,K-ATPase and use thereof for reduction of intraocular pressure
EP3325634A4 (en) 2015-07-21 2019-03-13 The Regents of The University of California GLUCOSE GROUND CHANGE WITH MOLECULAR VENTILATION VALVE
BR112018001310A2 (pt) 2015-07-22 2018-09-11 Phytopharma Int Ltd composições ingeríveis por abelha, métodos de uso das mesmas para a produção de mel e mel produzido por estas
US10870111B2 (en) 2015-07-22 2020-12-22 The University Of North Carolina At Chapel Hill Fluidic devices with bead well geometries with spatially separated bead retention and signal detection segments and related methods
EP3314183B1 (en) 2015-07-22 2020-09-02 The University of North Carolina at Chapel Hill Fluidic devices with freeze-thaw valves with ice-nucleating agents and related methods of operation and analysis
BR112018001267A2 (pt) 2015-07-23 2019-10-22 Merck Sharp & Dohme método de diagnosticar asma, uso de um antagonista do receptor de crth2, produto de fármaco, e, kit
CA2992616C (en) 2015-07-23 2023-01-03 Asuragen, Inc. Methods, compositions, kits, and uses for analysis of nucleic acids comprising repeating a/t-rich segments
CA3025896A1 (en) 2015-07-23 2017-01-26 The Regents Of The University Of California Antibodies to coagulation factor xia and uses thereof
JP6923509B2 (ja) 2015-07-28 2021-08-18 オトノミ—，インク． 切断型のｔｒｋｂおよびｔｒｋｃのアンタゴニストを使用する処置
US10941176B2 (en) 2015-07-28 2021-03-09 Caris Science, Inc. Therapeutic oligonucleotides
CN108350455A (zh) 2015-07-29 2018-07-31 阿布特斯生物制药公司 用于使b型肝炎病毒基因表达沉默的组合物和方法
EP3328995B1 (en) 2015-07-29 2021-03-31 Hadasit Medical Research Services And Development Large scale production of retinal pigment epithelial cells
CA2993009A1 (en) 2015-07-31 2017-02-09 Research Institute At Nationwide Children's Hospital Peptides and antibodies for the removal of biofilms
EP3331546B1 (en) 2015-08-03 2023-10-04 Biokine Therapeutics Ltd. Cxcr4 inhibitor for the treatment of cancer
BR112018002150A2 (pt) 2015-08-03 2018-09-18 Bioverativ Therapeutics Inc proteínas de fusão do fator ix e métodos de fabricação e uso das mesmas
WO2017024173A1 (en) 2015-08-04 2017-02-09 The Regents Of The University Of Colorado Multiplexed binary assembly and quantitative tracking of bacterial populations
EP3331995A1 (en) 2015-08-05 2018-06-13 Cell Cure Neurosciences Ltd. Preparation of photoreceptors for the treatment of retinal diseases
ES2932823T3 (es) 2015-08-05 2023-01-26 Cell Cure Neurosciences Ltd Preparación de células del epitelio pigmentario de la retina
EP3334840A1 (en) 2015-08-10 2018-06-20 Stratos Genomics, Inc. Single molecule nucleic acid sequencing with molecular sensor complexes
US10584378B2 (en) 2015-08-13 2020-03-10 Centrillion Technology Holdings Corporation Methods for synchronizing nucleic acid molecules
US20180237790A1 (en) 2015-08-13 2018-08-23 Forrest Innovation Ltd. Formulations and compositions for delivery of nucleic acids to plant cells
PL3334454T3 (pl) 2015-08-14 2023-01-30 Zoetis Services Llc Kompozycje mycoplasma bovis
US10793895B2 (en) 2015-08-24 2020-10-06 Seven Bridges Genomics Inc. Systems and methods for epigenetic analysis
WO2017040380A2 (en) 2015-08-28 2017-03-09 Research Development Foundation Engineered antibody fc variants
CA2996762A1 (en) 2015-08-31 2017-03-09 Technovax, Inc. Human respiratory syncytial virus (hrsv) virus-like particles (vlps) based vaccine
US10584380B2 (en) 2015-09-01 2020-03-10 Seven Bridges Genomics Inc. Systems and methods for mitochondrial analysis
US10724110B2 (en) 2015-09-01 2020-07-28 Seven Bridges Genomics Inc. Systems and methods for analyzing viral nucleic acids
CN114525280A (zh) 2015-09-02 2022-05-24 阿尔尼拉姆医药品有限公司 程序性细胞死亡1配体1（PD-L1）的iRNA组合物及其使用方法
CN108348571B (zh) 2015-09-03 2022-03-22 艾瑞朗医疗公司 拟肽大环化合物及其用途
WO2017040930A2 (en) 2015-09-03 2017-03-09 The Trustees Of The University Of Pennsylvania Biomarkers predictive of cytokine release syndrome
US10448595B2 (en) 2015-09-03 2019-10-22 Seminis Vegetable Seeds, Inc. Downy mildew resistant lettuce plants
US10765706B2 (en) 2015-09-03 2020-09-08 University Of South Florida Method of stem cell delivery into the brain during chronic disease using blood brain barrier permeabilizers
US10993959B2 (en) 2015-09-04 2021-05-04 Regents Of The University Of Minnesota Methods and compositions for increasing the suppressive function of regulatory T-cells (Tregs)
CN107969127B (zh) 2015-09-08 2022-09-06 赛瑞品股份有限公司 Apoa-1融合多肽及相关组合物和方法
US10647981B1 (en) 2015-09-08 2020-05-12 Bio-Rad Laboratories, Inc. Nucleic acid library generation methods and compositions
US9499861B1 (en) 2015-09-10 2016-11-22 Insilixa, Inc. Methods and systems for multiplex quantitative nucleic acid amplification
WO2017042816A1 (en) 2015-09-10 2017-03-16 Yeda Research And Development Co. Ltd. Ablation of perforin positive dendritic cells in cancer treatment
EP3347487B1 (en) 2015-09-11 2021-07-14 INSERM (Institut National de la Santé et de la Recherche Médicale) Non-invasive methods for assessing genetic integrity of pluripotent stem cells
WO2017048620A1 (en) 2015-09-14 2017-03-23 Alnylam Pharmaceuticals, Inc. Polynucleotide agents targeting patatin-like phospholipase domain containing 3 (pnpla3) and methods of use thereof
TW201726140A (zh) 2015-09-17 2017-08-01 瑞典商阿斯特捷利康公司 治療癌症之新型生物標記及方法
EP3350351B1 (en) 2015-09-18 2020-08-05 The Trustees of Columbia University in the City of New York Virome capture sequencing platform, methods of designing and constructing and methods of using
WO2017049118A2 (en) 2015-09-18 2017-03-23 Siemens Healthcare Diagnostics Inc. Reagents and methods for analysis of hiv
JP6956709B2 (ja) 2015-09-22 2021-11-02 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ Ｏｍｐｇバリアント
DK3353177T3 (da) 2015-09-23 2020-08-24 Janssen Pharmaceutica Nv Tricykliske heterocykler til behandling af cancer
EP3353214B1 (en) 2015-09-25 2021-08-18 Universität Duisburg-Essen Agents inhibiting kallikrein-8 for use in the prevention or treatment of alzheimer's disease
WO2017058938A1 (en) 2015-09-29 2017-04-06 Research Institute At Nationwide Children's Hospital Methods for detecting hepatic fibrosis and responsiveness to therapy
EP3355939A4 (en) 2015-09-30 2019-04-17 Trustees of Boston University MICROBIAL DEADMAN AND PASS CODE EMERGENCY STOP SWITCHES
WO2017054058A1 (en) 2015-09-30 2017-04-06 Immunexpress Pty Ltd Pathogen biomarkers and uses therefor
EP3868751B1 (en) 2015-10-02 2023-10-25 Sentinel Oncology Limited 2-aminoquinazoline derivatives as p70s6 kinase inhibitors
WO2017112025A2 (en) 2015-10-05 2017-06-29 The University Of North Carolina At Chapel Hill Decoding methods for multiplexing assays and associated fluidic devices, kits, and solid supports
WO2017060662A1 (en) 2015-10-07 2017-04-13 The Secretary Of State For Health Method for providing a control for use in a screen for pathogenic virus
US10668068B2 (en) 2015-10-07 2020-06-02 The Research Foundation For The State University Of New York Treating cancer with drug combinations
CN105219767B (zh) 2015-10-09 2018-02-13 上海交通大学 大豆转化事件shzd32‑01及其应用方法
EP3359695B1 (en) 2015-10-10 2020-04-15 Guardant Health, Inc. Methods and applications of gene fusion detection in cell-free dna analysis
WO2017066719A2 (en) 2015-10-14 2017-04-20 Research Institute At Nationwide Children's Hospital Hu specific interfering agents
EP3362074B1 (en) 2015-10-16 2023-08-09 President and Fellows of Harvard College Regulatory t cell pd-1 modulation for regulating t cell effector immune responses
US11347704B2 (en) 2015-10-16 2022-05-31 Seven Bridges Genomics Inc. Biological graph or sequence serialization
JP6936952B2 (ja) 2015-10-16 2021-09-22 アストラゼネカ アクチボラグ 細胞ゲノムの誘導性改変
WO2017070096A1 (en) 2015-10-18 2017-04-27 Affymetrix, Inc. Multiallelic genotyping of single nucleotide polymorphisms and indels
CA3002157A1 (en) 2015-10-20 2017-04-27 FUJIFILM Cellular Dynamics, Inc. Methods for directed differentiation of pluripotent stem cells to immune cells
WO2017070643A1 (en) * 2015-10-22 2017-04-27 University Of Maryland, Baltimore Methods for extracting nucleic acids from dried blood and uses thereof
USD799715S1 (en) 2015-10-23 2017-10-10 Gene POC, Inc. Fluidic centripetal device
JP7030689B2 (ja) 2015-10-23 2022-03-07 ファイザー インコーポレイティッド 抗ｉｌ－２抗体ならびにその組成物及び使用
AU2016347652A1 (en) 2015-10-26 2018-05-24 Cell Cure Neurosciences Ltd. Preparation of retinal pigment epithelium cells
US11092607B2 (en) 2015-10-28 2021-08-17 The Board Institute, Inc. Multiplex analysis of single cell constituents
KR101651817B1 (ko) 2015-10-28 2016-08-29 대한민국 Ngs 라이브러리 제작용 프라이머 세트 및 이를 이용한 ngs 라이브러리 제작방법 및 키트
WO2017075297A1 (en) 2015-10-28 2017-05-04 The Broad Institute Inc. High-throughput dynamic reagent delivery system
US10865396B2 (en) 2015-10-29 2020-12-15 Temple University—Of the Commonwealth System of Higher Education Modification of 3′ terminal ends of nucleic acids by DNA polymerase theta
IL242380A0 (en) 2015-10-29 2016-02-01 Yeda Res & Dev A method for inducing the division of cardiomyocytes and treating heart diseases
AU2016343978A1 (en) 2015-10-29 2018-05-17 Dana-Farber Cancer Institute, Inc. Methods for identification, assessment, prevention, and treatment of metabolic disorders using PM20D1 and N-lipidated amino acids
MX2018005468A (es) 2015-10-30 2018-11-09 The Us Secretary Department Of Health And Man Services Terapia dirigida contra el cáncer.
WO2017075559A1 (en) 2015-10-30 2017-05-04 E. I. Du Pont De Nemours And Company Dihydroorotate dehydrogenase inhibitor compositions effective as herbicides
CN108350485A (zh) 2015-10-30 2018-07-31 精密科学发展有限责任公司 血浆dna的多重扩增检测测定以及分离和检测
WO2017075389A1 (en) 2015-10-30 2017-05-04 The Regents Of The Universtiy Of California Methods of generating t-cells from stem cells and immunotherapeutic methods using the t-cells
SI3370733T1 (sl) 2015-11-02 2021-11-30 Board Of Regents The University Of Texas System Postopek za aktivacijo CD40 in blokada imunske nadzorne točke
US20180303974A1 (en) 2015-11-03 2018-10-25 Ariel-University Research And Development Company Ltd. Compositions for regeneration and repair of neural tissue
JP6902185B2 (ja) 2015-11-03 2021-07-14 リージェンツ オブ ザ ユニバーシティ オブ ミネソタ Ｃｄ２００阻害剤及びその使用方法
EP3371221A2 (en) 2015-11-07 2018-09-12 MultiVir Inc. Methods and compositions comprising tumor suppressor gene therapy and immune checkpoint blockade for the treatment of cancer
WO2017080980A1 (en) 2015-11-09 2017-05-18 Astrazeneca Ab Dihydropyrrolopyrazinone derivatives useful in the treatment of cancer
WO2017083296A1 (en) 2015-11-09 2017-05-18 The Children's Hospital Of Philadelphia Glypican 2 as a cancer marker and therapeutic target
LT3374359T (lt) 2015-11-09 2020-03-25 Astrazeneca Ab Dihidroimidazopirazinono deriniai, tinkami panaudoti vėžio gydymui
AU2016352829B2 (en) 2015-11-10 2022-11-10 Vilmorin & Cie Resistance to ToLCNDV in squash
US20180327855A1 (en) 2015-11-11 2018-11-15 Ramot At Tel-Aviv University Ltd. Methods of detecting 5-hydroxymethylcytosine and diagnosing of cancer
JP6685396B2 (ja) 2015-11-20 2020-04-22 シージーン アイエヌシー 標的分析物質に対するデータセットの補正方法
BR112018010089A2 (pt) 2015-11-20 2018-11-13 4D Pharma Res Ltd composições compreendendo cepas bacterianas
GB201520497D0 (en) 2015-11-20 2016-01-06 4D Pharma Res Ltd Compositions comprising bacterial strains
GB201520631D0 (en) 2015-11-23 2016-01-06 4D Pharma Res Ltd Compositions comprising bacterial strains
GB201520638D0 (en) 2015-11-23 2016-01-06 4D Pharma Res Ltd Compositions comprising bacterial strains
EP3384286B1 (en) 2015-11-30 2023-04-19 Kadimastem Ltd. Methods for differentiating and purifying pancreatic endocrine cells
EP3176183A1 (en) 2015-12-02 2017-06-07 Yeda Research and Development Co. Ltd Compositions and methods for treating cancer not resistant to a tyrosine kinase inhibitor (tki)
CA3006743A1 (en) 2015-12-03 2017-06-08 Agios Pharmaceuticals, Inc. Mat2a inhibitors for treating mtap null cancer
WO2017100177A1 (en) 2015-12-07 2017-06-15 Bio-Rad Laboratories, Inc. Dimeric reverse transcriptase
EP3387411B1 (en) 2015-12-08 2023-05-10 Biomatrica, INC. Reduction of erythrocyte sedimentation rate
EP3387147A1 (en) 2015-12-09 2018-10-17 Life Technologies Corporation Detection and quantification of nucleic acid molecules associated with a surface
JP2018536689A (ja) 2015-12-10 2018-12-13 アルナイラム ファーマシューティカルズ， インコーポレイテッドＡｌｎｙｌａｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． ステロール調節エレメント結合タンパク質（ＳＲＥＢＰ）シャペロン（ＳＣＡＰ）ｉＲＮＡ組成物およびその使用方法
EP3387107B1 (en) 2015-12-11 2020-08-12 Spartan Bioscience Inc. Tube sealing system and methods for nucleic acid amplification
EP4059507A1 (en) 2015-12-16 2022-09-21 Ramot at Tel-Aviv University Ltd. Particles comprising decellularized omentum
EP3390658B1 (en) 2015-12-16 2022-08-03 Standard BioTools Inc. High-level multiplex amplification
EP3181699A1 (en) 2015-12-17 2017-06-21 Oniris Micrornas as predictive biomarkers of type 1 diabetes
WO2017106447A1 (en) 2015-12-18 2017-06-22 Pioneer Hi-Bred International, Inc. Genetic loci associated with reproductive growth phenotypes in soybean and methods of use
US10920224B2 (en) 2015-12-22 2021-02-16 The Regents Of The University Of Colorado, A Body Corporate Protecting RNAs from degradation using engineered viral RNAs
AU2016377391B2 (en) 2015-12-24 2022-09-01 Immunexpress Pty Ltd Triage biomarkers and uses therefor
WO2017117358A1 (en) 2015-12-30 2017-07-06 Bio-Rad Laboratories, Inc. Digital protein quantification
WO2017117287A1 (en) 2015-12-30 2017-07-06 Bio-Rad Laboratories, Inc. Split-cycle and tape amplification
WO2017120216A2 (en) 2016-01-04 2017-07-13 Gen-Probe Incorporated Methods and compositions for detecting candida species
CA3009127A1 (en) 2016-01-06 2017-07-13 Yeda Research And Development Co. Ltd. Compositions and methods for treating malignant, autoimmune and inflammatory diseases
CN108431223A (zh) 2016-01-08 2018-08-21 生物辐射实验室股份有限公司 每液滴分辨率下的多个珠
JP7078536B2 (ja) 2016-01-08 2022-05-31 アルトゥルバイオ， インコーポレイテッド 四価抗ｐｓｇｌ－１抗体とその使用
WO2017122203A1 (en) 2016-01-11 2017-07-20 Technion Research & Development Foundation Limited Methods of determining prognosis of sepsis and treating same
AU2017207341A1 (en) 2016-01-12 2018-08-02 Interleukin Genetics, Inc. Methods for predicting response to treatment
US10364468B2 (en) 2016-01-13 2019-07-30 Seven Bridges Genomics Inc. Systems and methods for analyzing circulating tumor DNA
WO2017122039A1 (en) 2016-01-13 2017-07-20 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for predicting pancreatic cancer treatment response
LT3402880T (lt) 2016-01-15 2024-03-12 Thermo Fisher Scientific Baltics Uab Termofiliniai dnr polimerazės mutantai
US20190144936A1 (en) 2016-01-15 2019-05-16 Massachusetts Institute Of Technology Semi-permeable arrays for analyzing biological systems and methods of using same
WO2017122096A1 (en) 2016-01-15 2017-07-20 Astrazeneca Ab Gene modification assays
WO2017127731A1 (en) 2016-01-21 2017-07-27 T2 Biosystems, Inc. Nmr methods and systems for the rapid detection of bacteria
TW201936640A (zh) 2016-01-21 2019-09-16 美商輝瑞股份有限公司 對表皮生長因子受體變異體ｉｉｉ具特異性之抗體類及彼等之用途
WO2017125931A1 (en) 2016-01-21 2017-07-27 The State Of Israel, Ministry Of Agriculture & Rural Development, Agricultural Research Organization (Aro) (Volcani Center) Parthenocarpic plants and methods of producing same
US20190032104A1 (en) 2016-01-21 2019-01-31 T2 Biosystems, Inc. Rapid antimicrobial susceptibility testing using high-sensitivity direct detection methods
UA125252C2 (uk) 2016-01-21 2022-02-09 Пфайзер Інк. Химерний антигенний рецептор, що націлений на варіант iii рецептора епідермального фактора росту
US10982286B2 (en) 2016-01-22 2021-04-20 Mayo Foundation For Medical Education And Research Algorithmic approach for determining the plasma genome abnormality PGA and the urine genome abnormality UGA scores based on cell free cfDNA copy number variations in plasma and urine
IL243839B (en) 2016-01-28 2018-01-31 Sp Nano Ltd Conductive wires
WO2017132538A1 (en) 2016-01-29 2017-08-03 The Regents Of The University Of Michigan Amlexanox analogs
WO2017132483A1 (en) 2016-01-29 2017-08-03 Vanderbilt University Free-solution response function interferometry
US11261433B2 (en) 2016-01-31 2022-03-01 Hadasit Medical Research Services And Development Ltd. Autosomal-identical pluripotent stem cell populations having non-identical sex chromosomal composition and uses thereof
US11753461B2 (en) 2016-02-01 2023-09-12 Bioverativ Therapeutics Inc. Optimized factor VIII genes
EP3199642A1 (en) 2016-02-01 2017-08-02 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Plant breeding using high throughput sequencing
US11230578B2 (en) 2016-02-04 2022-01-25 Yeda Research And Development Co. Ltd. Peptides and use of same in the treatment of diseases, disorders or conditions associated with a mutant P53
WO2017136751A1 (en) 2016-02-05 2017-08-10 The Broad Institute Inc. Multi-stage, multiplexed target isolation and processing from heterogeneous populations
CA3004914A1 (en) 2016-02-05 2017-08-10 Pioneer Hi-Bred International, Inc. Genetic loci associated with brown stem rot resistance in soybean and methods of use
KR102300738B1 (ko) 2016-02-05 2021-09-10 주식회사 씨젠 타겟 분석물질에 대한 데이터 세트의 노이즈 수준 감축 방법
EA201891629A1 (ru) 2016-02-09 2019-03-29 Сибас Юс Ллс Способы и композиции для повышения эффективности нацеленной модификации генов с применением опосредуемой олигонуклеотидами репарации генов
US11028453B2 (en) 2016-02-11 2021-06-08 Pioneer Hi-Bred International, Inc. QTLs associated with and methods for identifying lodging resistance in soybean
WO2017139419A1 (en) 2016-02-11 2017-08-17 Qiagen Waltham, Inc. Polyphenolic additives in sequencing-by-synthesis
EP3413910A1 (en) 2016-02-12 2018-12-19 Janssen Pharmaceutica NV Anti-vista (b7h5) antibodies
ES2771223T3 (es) 2016-02-14 2020-07-06 Yeda Res & Dev Diagnóstico, predicción y tratamiento de la obesidad recidivante basados en el microbioma
WO2017138008A2 (en) 2016-02-14 2017-08-17 Yeda Research And Development Co. Ltd. Methods of modulating protein exocytosis and uses of same in therapy
US20190160098A1 (en) 2016-02-16 2019-05-30 Dana-Farber Cancer Institute, Inc. Chimeric antigen receptors and methods of use thereof
MX2018009984A (es) 2016-02-16 2019-01-21 Yissum Res Dev Co Of Hebrew Univ Jerusalem Ltd Análogos no proteínicos de fenilananina para la inhibicion del crecimiento de cianobacterias y plantas.
AU2017219859A1 (en) 2016-02-16 2018-08-09 Dana-Farber Cancer Institute, Inc. Immunotherapy compositions and methods
WO2017144523A1 (en) 2016-02-22 2017-08-31 Evaxion Biotech Aps Proteins and nucleic acids useful in vaccines targeting staphylococcus aureus
US11053476B2 (en) 2016-02-23 2021-07-06 Exostem Biotec Ltd. Generation of cancer stem cells and use thereof
US10262102B2 (en) 2016-02-24 2019-04-16 Seven Bridges Genomics Inc. Systems and methods for genotyping with graph reference
BR112018015589A2 (pt) 2016-02-25 2019-10-01 Dupont Nutrition Biosci Aps método para produzir hidrolisado de proteína que emprega uma tripeptidil peptidase de aspergillus fumigatus
US10266813B2 (en) 2016-02-29 2019-04-23 Genia Technologies, Inc. Exonuclease deficient polymerases
US10590480B2 (en) 2016-02-29 2020-03-17 Roche Sequencing Solutions, Inc. Polymerase variants
ES2880331T3 (es) 2016-02-29 2021-11-24 Genia Tech Inc Variantes de polimerasa
CN108699540A (zh) 2016-02-29 2018-10-23 吉尼亚科技公司 用于纳米孔测序的聚合酶-模板复合物
US20190085378A1 (en) 2016-03-03 2019-03-21 Memed Diagnostics Ltd. Analyzing rna for diagnosing infection type
DK3419991T3 (da) 2016-03-04 2023-01-16 Danisco Us Inc Modificerede ribosomale genpromotorer til proteinproduktion i mikroorganismer
SG11201807195VA (en) 2016-03-04 2018-09-27 4D Pharma Plc Compositions comprising bacterial blautia strains for treating visceral hypersensitivity
WO2017153982A1 (en) 2016-03-06 2017-09-14 Yeda Research And Development Co. Ltd. Method for modulating myelination
WO2017155858A1 (en) 2016-03-07 2017-09-14 Insilixa, Inc. Nucleic acid sequence identification using solid-phase cyclic single base extension
US9771623B1 (en) 2016-03-15 2017-09-26 The Board Of Regents Of The University Of Texas System Molecular typing system for flavivirus diagnostics
CN109310885B (zh) 2016-03-15 2022-05-31 梅尔莎纳医疗公司 NaPi2b靶向抗体-药物缀合物及其使用方法
US10731166B2 (en) 2016-03-18 2020-08-04 Caris Science, Inc. Oligonucleotide probes and uses thereof
RU2749025C2 (ru) 2016-03-24 2021-06-03 Трагара Фармасьютикалз, Инк. Лечение рака при помощи tg02
JP7086855B2 (ja) 2016-03-28 2022-06-20 エヌキャン ジェノミクス， インコーポレイテッド 連結された二重鎖標的捕捉
US10961573B2 (en) 2016-03-28 2021-03-30 Boreal Genomics, Inc. Linked duplex target capture
CN109071653A (zh) 2016-03-29 2018-12-21 詹森生物科技公司 用增加的抗-il12和/或-23抗体给药间隔治疗牛皮癣
US20190177391A1 (en) 2016-03-31 2019-06-13 Baylor Research Institute Angiopoietin-like protein 8 (angptl8)
CA3054674A1 (en) 2016-04-04 2017-12-10 Sinopia Biosciences, Inc. Treating extrapyramidal syndrome using trapidil
EP3440221A1 (en) 2016-04-06 2019-02-13 Life Technologies Corporation Compositions, methods, and kits for synthesis and detection of nucleic acids
US10551384B2 (en) 2016-04-07 2020-02-04 Rutgers, The State University Of New Jersey MTOR kinase mutations and methods of use thereof
US10421785B2 (en) 2016-04-11 2019-09-24 Bar-Ilan University Delta receptor agonist peptides and use thereof
EP3442719B1 (en) 2016-04-11 2021-09-01 APDN (B.V.I.) Inc. Method of marking cellulosic products
WO2017180420A1 (en) 2016-04-11 2017-10-19 Board Of Regents, The University Of Texas System Methods and compositions for detecting single t cell receptor affinity and sequence
AU2017250076B2 (en) 2016-04-12 2021-07-22 The Regents Of The University Of Michigan Bet protein degraders
EP3442326A1 (en) 2016-04-13 2019-02-20 Altria Client Services LLC Tobacco plants exhibiting altered photosynthesis and methods of making and using the same
WO2017178587A1 (en) 2016-04-14 2017-10-19 INSERM (Institut National de la Santé et de la Recherche Médicale) Method for universal detection and quantification of mycoplasma (mollicutes) 16s rdna by quantitative polymerase chain reaction amplifying a 1.5 kilobase fragment
JP2019517780A (ja) 2016-04-14 2019-06-27 ティー２ バイオシステムズ，インコーポレーテッド 複合試料における増幅のための方法及びシステム
CN109328069B (zh) 2016-04-15 2023-09-01 亿一生物医药开发(上海)有限公司 Il-22在治疗坏死性小肠结肠炎中的用途
UA125382C2 (uk) 2016-04-15 2022-03-02 Імьюнекст Інк. Антитіла проти людського vista та їх застосування
MA45295A (fr) 2016-04-19 2019-02-27 Alnylam Pharmaceuticals Inc Composition d'arni de protéine de liaison de lipoprotéines haute densité (hdlbp/vigiline) et procédés pour les utiliser
WO2017182495A1 (en) 2016-04-20 2017-10-26 Astrazeneca Ab Indazole derivatives that down-regulate the estrogen receptor and possess anti-cancer activity
US20190145961A1 (en) 2016-04-20 2019-05-16 Washington University Ppar agonist or lxr agonist for use in the treatment of systemic lupus erythematosus by modulation of lap activity
US10125135B2 (en) 2016-04-20 2018-11-13 Astrazeneca Ab Chemical compounds
CA3021914A1 (en) 2016-04-27 2017-11-02 Gen-Probe Incorporated Blood cell lysis reagent
US10781481B2 (en) 2016-04-27 2020-09-22 Bio-Rad Laboratories, Inc. miRNA transcriptome methods and compositions
KR102527840B1 (ko) 2016-04-29 2023-05-03 화이자 인코포레이티드 인터페론 베타 항체 및 그의 용도
JP2019518440A (ja) 2016-05-03 2019-07-04 ダニスコ・ユーエス・インク プロテアーゼ変異体およびその使用
US20170321286A1 (en) 2016-05-05 2017-11-09 Exact Sciences Corporation Detection of lung neoplasia by amplification of rna sequences
CA3022911A1 (en) 2016-05-05 2017-11-09 Exact Sciences Development Company, Llc Detection of lung neoplasia by analysis of methylated dna
US10619205B2 (en) 2016-05-06 2020-04-14 Life Technologies Corporation Combinatorial barcode sequences, and related systems and methods
WO2017193097A1 (en) 2016-05-06 2017-11-09 Girihlet Inc. Methods and compositions for determining specifc tcr and bcr chain pairings
EP3978625A1 (en) 2016-05-12 2022-04-06 Pioneer Hi-Bred International, Inc. Methods for simultaneous pooled genotyping of plants
CN109477079A (zh) 2016-05-12 2019-03-15 帝斯曼知识产权资产管理有限公司 增加微藻中ω-3多不饱和脂肪酸产量的方法
EP3458611B1 (en) 2016-05-17 2023-11-08 Genecentric Therapeutics, Inc. Methods for subtyping of lung squamous cell carcinoma
EP3458612B1 (en) 2016-05-17 2023-11-15 Genecentric Therapeutics, Inc. Methods for subtyping of lung adenocarcinoma
WO2017203520A1 (en) 2016-05-22 2017-11-30 Yeda Research And Development Co. Ltd. Methods of using pulmonary cells for transplantation and induction of tolerance
EP3464630A1 (en) 2016-05-23 2019-04-10 Yissum Research Development Company of the Hebrew University of Jerusalem, Ltd. Methods of diagnosing cancer using cancer testis antigens
IL245861A0 (en) 2016-05-25 2016-09-04 Yeda Res & Dev Use of substances to treat drug-resistant tumors
WO2017205686A1 (en) 2016-05-25 2017-11-30 Caris Science, Inc. Oligonucleotide probes and uses thereof
AU2017269364B2 (en) 2016-05-25 2023-08-31 Salk Institute For Biological Studies Compositions and methods for organoid generation and disease modeling
GB2600627B (en) 2016-05-27 2022-12-07 Personalis Inc Personalized genetic testing
SG11201810332TA (en) 2016-05-27 2018-12-28 Etubics Corp Neoepitope vaccine compositions and methods of use thereof
US11299783B2 (en) 2016-05-27 2022-04-12 Personalis, Inc. Methods and systems for genetic analysis
US10612101B2 (en) 2016-05-27 2020-04-07 Roche Molecular Systems, Inc. Compositions and methods for detection of Mycoplasma genitalium
WO2017202894A1 (en) 2016-05-27 2017-11-30 Roche Diagnostics Gmbh Compositions and methods for detection of trichomonas vaginalis
US10202650B2 (en) 2016-05-31 2019-02-12 Youhealth Biotech, Limited Methods for monitoring ELOVL2, KLF14 and PENK gene expression following treatment with vitamin C
WO2017210437A1 (en) 2016-06-01 2017-12-07 Life Technologies Corporation Methods and systems for designing gene panels
WO2017205957A1 (en) 2016-06-01 2017-12-07 9087-4405 Quebec Inc. Remote access system and method for plant pathogen management
US20190100732A1 (en) 2016-06-02 2019-04-04 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Assay for the removal of methyl-cytosine residues from dna
US10584363B2 (en) * 2016-06-03 2020-03-10 Takara Bio Usa, Inc. Methods of producing and using single-stranded deoxyribonucleic acids and compositions for use in practicing the same
US10036024B2 (en) 2016-06-03 2018-07-31 Purdue Research Foundation siRNA compositions that specifically downregulate expression of a variant of the PNPLA3 gene and methods of use thereof for treating a chronic liver disease or alcoholic liver disease (ALD)
WO2017212476A1 (en) 2016-06-05 2017-12-14 Tel Hashomer Medical Research Infrastructure And Services Ltd. Novel molecules for the treatment of inflammation
CN109477111B (zh) 2016-06-07 2023-12-15 塞弗德公司 热稳定聚合酶抑制剂组合物和方法
EP3907300A1 (en) 2016-06-08 2021-11-10 University Of Iowa Research Foundation Compositions for detecting predisposition to cardiovascular disease
EP3468610A1 (en) 2016-06-09 2019-04-17 OPKO Biologics Ltd. Long-acting oxyntomodulin formulation and methods of producing and administering same
JP6803930B2 (ja) 2016-06-10 2021-01-06 ジェン−プローブ・インコーポレーテッド Ｚｉｋａウイルス核酸を検出するための組成物および方法
EP3469083A1 (en) 2016-06-10 2019-04-17 Alnylam Pharmaceuticals, Inc. COMPLEMENT COMPONENT C5 iRNA COMPOSITIONS AND METHODS OF USE THEREOF FOR TREATING PAROXYSMAL NOCTURNAL HEMOGLOBINURIA (PNH)
CA2932910A1 (en) 2016-06-14 2017-12-14 Entos Pharmaceuticals Inc. Methods for diagnosing and treating metastatic cancer
US20170356025A1 (en) 2016-06-14 2017-12-14 Roche Molecular Systems, Inc. Internal control probes for improving pcr assay performance
CN109477150B (zh) 2016-06-16 2023-03-31 生命技术公司 用于检测微生物的组合物、方法和试剂盒
CA2970834A1 (en) 2016-06-17 2017-12-17 Advatect Diagnostics, Llc Methods and compositions for identifying and quantifying microbial dna
EP3472342A1 (en) 2016-06-19 2019-04-24 Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. Screening for chemotherapy resistance in human haploid cells
EP3260552A1 (en) 2016-06-20 2017-12-27 Istituto Europeo di Oncologia (IEO) Methods and kits comprising gene signatures for stratifying breast cancer patients
CN109641942A (zh) 2016-06-20 2019-04-16 路易斯安娜州立大学监测委员会, 农业和机械学院 绿藻碳酸氢盐转运蛋白及其用途
IL246378A0 (en) 2016-06-21 2016-11-30 Technion Res & Dev Foundation A hybrid matrix of polymers that adhere to the mucosa and a lipidic drug release system for the treatment of oral cancer
AR108853A1 (es) 2016-06-22 2018-10-03 Univ North Carolina State Método para aumentar la eficacia en el uso de nitrógeno y/o la eficiencia en la utilización del nitrógeno en las plantas
ES2929047T3 (es) 2016-06-24 2022-11-24 Scripps Research Inst Transportador de nucleósido trifosfato novedoso y usos del mismo
CN110291402B (zh) 2016-06-27 2023-09-01 朱诺治疗学股份有限公司 鉴定肽表位的方法、结合此类表位的分子和相关用途
DK3264087T3 (da) 2016-06-27 2020-07-20 Chimera Biotec Gmbh Fremgangsmåde og indretning til kvantificering af målmolekyler
MA45491A (fr) 2016-06-27 2019-05-01 Juno Therapeutics Inc Épitopes à restriction cmh-e, molécules de liaison et procédés et utilisations associés
US11155857B2 (en) 2016-06-27 2021-10-26 Dana-Farber Cancer Institute, Inc. Methods for measuring RNA translation rates
MX2019000022A (es) 2016-06-27 2019-09-18 Yeda Res & Dev Células veto generadas a partir de linfocitos t de memoria.
US11191849B2 (en) 2016-06-30 2021-12-07 Arbutus Biopharma Corporation Compositions and methods for delivering messenger RNA
US11034968B2 (en) 2016-06-30 2021-06-15 Kuehnle Agrosystems, Inc. Heterotrophic production methods for microbial biomass and bioproducts
CA3029582A1 (en) 2016-07-01 2018-01-04 Research Development Foundation Elimination of proliferating cells from stem cell-derived grafts
US10093986B2 (en) 2016-07-06 2018-10-09 Youhealth Biotech, Limited Leukemia methylation markers and uses thereof
EP3481941A4 (en) 2016-07-06 2020-04-15 Youhealth Biotech, Limited BREAST AND OVARY CANCER METHYLATION MARKERS AND USES THEREOF
EP3481403B1 (en) 2016-07-06 2022-02-09 Youhealth Biotech, Limited Solid tumor methylation markers and uses thereof
US11340223B2 (en) 2016-07-10 2022-05-24 Memed Diagnostics Ltd. Early diagnosis of infections
EP4141448A1 (en) 2016-07-10 2023-03-01 MeMed Diagnostics Ltd. Protein signatures for distinguishing between bacterial and viral infections
WO2018013509A1 (en) 2016-07-11 2018-01-18 Arizona Board Of Regents On Behalf Of The University Of Arizona Compositions and methods for diagnosing and treating arrhythmias
EP4303228A3 (en) 2016-07-11 2024-03-13 OPKO Biologics Ltd. Long-acting coagulation factor vii and methods of producing same
IL246722A0 (en) 2016-07-11 2016-09-29 Yeda Res & Dev Combined treatment to increase endogenous synthesis of nitric oxide
EP3481191A2 (en) 2016-07-11 2019-05-15 Yissum Research and Development Company of the Hebrew University of Jerusalem Ltd. Systems and methods for growing cells in vitro
KR20190038833A (ko) 2016-07-11 2019-04-09 보누스 테라퓨틱스 리미티드 조직 재생용 세포 조성물
WO2018011803A1 (en) 2016-07-11 2018-01-18 The National Institute for Biotechnology in the Negev Ltd. Fusion proteins with extended serum half life
US10676734B2 (en) 2016-07-12 2020-06-09 Life Technologies Corporation Compositions and methods for detecting nucleic acid regions
WO2018013710A1 (en) 2016-07-12 2018-01-18 F. Hoffman-La Roche Ag Primer extension target enrichment
TWI802545B (zh) 2016-07-13 2023-05-21 英商４Ｄ製藥有限公司 包含細菌菌株之組合物
WO2018013883A1 (en) 2016-07-14 2018-01-18 Caprion Proteomics Inc. Biomarkers of latent tuberculosis infection
RU2019104075A (ru) 2016-07-15 2020-08-17 Посейда Терапьютикс, Инк. Химерные рецепторы антигенов (car), специфические для muc1, и способы их применения
US20190177421A1 (en) 2016-07-15 2019-06-13 Poseida Therapeutics, Inc. Chimeric antigen receptors and methods for use
WO2018017710A1 (en) 2016-07-19 2018-01-25 Exact Sciences Development Company, Llc Nucleic acid control molecules from non-human organisms
ES2902174T3 (es) 2016-07-19 2022-03-25 Exact Sciences Dev Co Llc ADN de control metilado
EP3487616B1 (en) 2016-07-21 2023-08-09 Takara Bio USA, Inc. Multi-z imaging of wells of multi-well devices and liquid dispensing into the wells
WO2018018008A1 (en) 2016-07-22 2018-01-25 Oregon Health & Science University Single cell whole genome libraries and combinatorial indexing methods of making thereof
US20190203270A1 (en) 2016-07-24 2019-07-04 Yeda Research And Development Co., Ltd. Methods and kits for analyzing dna binding moieties attached to dna
US10149839B2 (en) 2016-07-25 2018-12-11 Astrazeneca Ab Chemical compounds
AU2017301881A1 (en) 2016-07-29 2019-02-07 Juno Therapeutics, Inc. Methods for assessing the presence or absence of replication competent virus
JP6999645B2 (ja) 2016-08-02 2022-02-04 エフ．ホフマン－ラ ロシュ アーゲー 核酸の増幅及び検出／定量の効率を改良するためのヘルパーオリゴヌクレオチド
EP3279337A1 (en) 2016-08-04 2018-02-07 Servizo Galego de Saúde (SERGAS) Use of short probes between 8 and 9 nucleotides in multiplex assays
ES2965761T3 (es) 2016-08-08 2024-04-16 Tech Innovation Momentum Fund Israel Limited Partnership Sistemas bacterianos para el análisis de polipéptidos ubiquitilados
EP3504553B1 (en) 2016-08-10 2022-04-20 Memed Diagnostics Ltd. System and method for analysis of biological data
CA3033951A1 (en) 2016-08-14 2018-02-22 Daniel Offen Mesenchymal cell-derived exosomes to treat neurological disorders
IL247368A0 (en) 2016-08-18 2016-11-30 Yeda Res & Dev Diagnostic and therapeutic uses of exosomes
US9963498B2 (en) 2016-08-18 2018-05-08 Wisconsin Alumni Research Foundation Peptides that inhibit syndecan-1 activation of VLA-4 and IGF-1R
CN110506127B (zh) 2016-08-24 2024-01-12 维拉科特Sd公司 基因组标签预测前列腺癌患者对术后放射疗法应答性的用途
WO2018037416A1 (en) 2016-08-25 2018-03-01 Yeda Research And Development Co. Ltd. Methods and compositions for treating autoimmune diseases
EP3504342A1 (en) 2016-08-26 2019-07-03 Life Technologies Corporation Nucleic acid extraction and amplification controls and methods of use thereof
IL304011A (en) * 2016-08-31 2023-08-01 Taro Pharma Ind Topical formulations of phenoldopam for the treatment of skin problems
US11250931B2 (en) 2016-09-01 2022-02-15 Seven Bridges Genomics Inc. Systems and methods for detecting recombination
CN116064795A (zh) 2016-09-02 2023-05-05 梅约医学教育与研究基金会 确定差异甲基化区域的甲基化状态的方法和试剂盒
JP2020501506A (ja) 2016-09-07 2020-01-23 イッサム リサーチ デベロップメント カンパニー オブ ザ ヘブリュー ユニバーシティー オブ エルサレム エルティーディー． 抗ＮＫｐ４６抗体およびその治療的使用
WO2018049261A1 (en) 2016-09-09 2018-03-15 Icellhealth Consulting Llc Oncolytic virus expressing immune checkpoint modulators
US11208664B2 (en) 2016-09-12 2021-12-28 Massachusetts Institute Of Technology Transcriptional sensor for bile acids in bacteroides thetaiotaomicron
AU2017326175B2 (en) 2016-09-13 2022-01-27 The Regents Of The University Of Michigan Fused 1,4-diazepines as BET protein degraders
CA3036834A1 (en) 2016-09-13 2018-03-22 The Regents Of The University Of Michigan Fused 1,4-oxazepines as bet protein degraders
US11485971B2 (en) 2016-09-14 2022-11-01 Yeda Research And Development Co. Ltd. CRISP-seq, an integrated method for massively parallel single cell RNA-seq and CRISPR pooled screens
KR102468174B1 (ko) 2016-09-15 2022-11-17 에프. 호프만-라 로슈 아게 멀티플렉스 pcr 수행 방법
WO2018051355A1 (en) 2016-09-19 2018-03-22 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Tamoxifen or tamoxifen in combination with arginine/citrulline for the use in the treatment of muscular dystrophy
CA3034643A1 (en) 2016-09-20 2018-03-29 Ellen Weisberg Compositions and methods for identification, assessment, prevention, and treatment of aml using usp10 biomarkers and modulators
GB201616116D0 (en) 2016-09-22 2016-11-09 Astrazeneca Ab Use of c-Met inhibitors to treat cancers harbouring MET mutations
US10829747B2 (en) 2016-09-22 2020-11-10 Roche Sequencing Solutions, Inc. Polymerase variants
US10487358B2 (en) 2016-09-23 2019-11-26 Grail, Inc. Methods of preparing and analyzing cell-free nucleic acid sequencing libraries
CN109890983A (zh) 2016-09-23 2019-06-14 生命技术公司 用于评估免疫应答的组合物和方法
WO2018060998A1 (en) 2016-09-29 2018-04-05 Memed Diagnostics Ltd. Methods of prognosis and treatment
JP2020500152A (ja) 2016-09-30 2020-01-09 ヤンセン バイオテツク，インコーポレーテツド 抗ｉｌ２３特異的抗体で乾癬を治療する安全かつ有効な方法
AU2017232187B2 (en) 2016-09-30 2023-11-09 Seminis Vegetable Seeds, Inc. Xanthomonas resistant brassica oleracea plants
EP3736324A1 (en) 2016-09-30 2020-11-11 The Governing Council Of The University Of Toronto System for identifying and targeting individual cells within a heterogeneous population for selective extraction of cellular content
KR102598351B1 (ko) 2016-10-05 2023-11-08 후지필름 셀룰러 다이내믹스, 인코포레이티드 만능 줄기 세포를 hla 동형 접합 면역 세포로 직접 분화시키기 위한 방법
WO2018067826A1 (en) 2016-10-05 2018-04-12 Cellular Dynamics International, Inc. Generating mature lineages from induced pluripotent stem cells with mecp2 disruption
WO2018065985A1 (en) 2016-10-06 2018-04-12 Moran Bercovici Device and method for isotachophoretic focusing large sample volumes
BR112019006865A2 (pt) 2016-10-06 2019-06-25 Poseida Therapeutics Inc caspases induzíveis e métodos para uso
EP4342290A2 (en) 2016-10-07 2024-03-27 Altria Client Services LLC Tobacco plants having increased nitrogen efficiency and methods of using such plants
US10422012B2 (en) 2016-10-10 2019-09-24 Roche Molecular Systems, Inc. Devices comprising bacteriophage PHI6 internal control compositions
WO2018071522A1 (en) 2016-10-11 2018-04-19 Life Technologies Corporation Rapid amplification of nucleic acids
IL248468A0 (en) 2016-10-13 2017-01-31 Technion Res & Dev Foundation Use of caspase-3 inhibitors and caspase-3 activators in the preparation of medical preparations for cancer treatment and wound healing
WO2018071814A1 (en) 2016-10-14 2018-04-19 The Trustees Of Columbia University In The City Of New York Methods of treating alcohol abuse disorder
IL248385A0 (en) 2016-10-18 2017-02-01 Yeda Res & Dev Treatment of circadian rhythm disorder
US11447835B2 (en) 2016-10-19 2022-09-20 Gen-Probe Incorporated Compositions and methods for detecting or quantifying hepatitis C virus
EP3433256B1 (en) 2016-10-24 2019-08-07 Astrazeneca AB 6,7,8,9-tetrahydro-3h-pyrazolo[4,3-f]isoquinoline derivative useful in the treatment of cancer
US20180127759A1 (en) 2016-10-28 2018-05-10 Massachusetts Institute Of Technology Dynamic genome engineering
CA3040930A1 (en) 2016-11-07 2018-05-11 Grail, Inc. Methods of identifying somatic mutational signatures for early cancer detection
US11031099B2 (en) 2016-11-09 2021-06-08 Roche Molecular Systems, Inc. Detection of sequence variants
US11162129B2 (en) 2016-11-09 2021-11-02 IsoPlexis Corporation Photoprotective mixtures as imaging reagents in sequencing-by-synthesis
US10793923B2 (en) 2016-11-09 2020-10-06 Roche Molecular Systems, Inc. Compositions and methods for detection of BK virus
US20190359956A1 (en) 2016-11-10 2019-11-28 Yeda Research And Development Co. Ltd. Phosphotriesterases for treating or preventing organophosphate exposure associated damage
EP3538546A1 (en) 2016-11-14 2019-09-18 Novartis AG Compositions, methods, and therapeutic uses related to fusogenic protein minion
MX2019005661A (es) 2016-11-16 2019-10-07 Janssen Biotech Inc Método para tratar la psoriasis con el anticuerpo específico anti-il23.
GB201619458D0 (en) 2016-11-17 2017-01-04 Spatial Transcriptomics Ab Method for spatial tagging and analysing nucleic acids in a biological specimen
EP3541954A1 (en) 2016-11-21 2019-09-25 Novozymes A/S Yeast cell extract assisted construction of dna molecules
WO2018098241A1 (en) 2016-11-22 2018-05-31 University Of Rochester Methods of assessing risk of recurrent prostate cancer
TWI788312B (zh) 2016-11-23 2023-01-01 美商阿尼拉製藥公司 絲胺酸蛋白酶抑制因子Ａ１ ｉＲＮＡ組成物及其使用方法
EP3545095A1 (en) 2016-11-28 2019-10-02 Yeda Research and Development Co., Ltd. Isolated polynucleotides and polypeptides and methods of using same for expressing an expression product of interest
WO2018100574A1 (en) 2016-11-30 2018-06-07 Yeda Research And Development Co. Ltd. Methods of treating liver toxicity and disorders
WO2018100511A1 (en) 2016-12-01 2018-06-07 Ramot At Tel-Aviv University Ltd. Combined treatment for nerve injuries
AU2017368328A1 (en) 2016-12-02 2019-07-18 Bioverativ Therapeutics Inc. Methods of inducing immune tolerance to clotting factors
CN110520150A (zh) 2016-12-02 2019-11-29 比奥维拉迪维治疗股份有限公司 使用嵌合凝血因子治疗血友病性关节病的方法
WO2018136163A2 (en) 2016-12-09 2018-07-26 Theripion, Inc. Tandem apoa-1 fusion polypeptides
US11268137B2 (en) 2016-12-09 2022-03-08 Boreal Genomics, Inc. Linked ligation
EP3551768B1 (en) 2016-12-12 2024-03-06 Grail, LLC Methods for tagging and amplifying rna template molecules for preparing sequencing libraries
WO2018111902A1 (en) 2016-12-12 2018-06-21 Multivir Inc. Methods and compositions comprising viral gene therapy and an immune checkpoint inhibitor for treatment and prevention of cancer and infectious diseases
GB201621123D0 (en) 2016-12-12 2017-01-25 4D Pharma Plc Compositions comprising bacterial strains
RU2761249C2 (ru) 2016-12-14 2021-12-06 Мерк Шарп энд Доум Корп. Человеческие генетические маркеры, ассоциированные с ответом на средства для лечения, которые целенаправленно воздействуют на токсин b clostridium difficile
KR20230166146A (ko) 2016-12-16 2023-12-06 알닐람 파마슈티칼스 인코포레이티드 트랜스티레틴(TTR) iRNA 조성물을 사용하여 TTR-관련 질병을 치료하거나 예방하는 방법
CN110139932A (zh) 2016-12-19 2019-08-16 生物辐射实验室股份有限公司 液滴加标的相邻性保留的标签化dna
WO2018118978A1 (en) 2016-12-20 2018-06-28 Bio-Rad Laboratories, Inc. Uv graft on microfluidic devices
US10427162B2 (en) 2016-12-21 2019-10-01 Quandx Inc. Systems and methods for molecular diagnostics
EP3559255A1 (en) 2016-12-23 2019-10-30 Grail, Inc. Methods for high efficiency library preparation using double-stranded adapters
US10793901B2 (en) 2016-12-28 2020-10-06 Roche Molecular Systems, Inc. Reversibly protected nucleotide reagents with high thermal stability
EP4001428B1 (en) 2016-12-29 2023-11-22 Seegene, Inc. Method for reducing primer dimer formation and increasing amplification efficiency
AU2018206560A1 (en) 2017-01-04 2019-07-18 Research Institute At Nationwide Children's Hospital Antibody fragments for the treatment of biofilm-related disorders
WO2018129214A1 (en) 2017-01-04 2018-07-12 Complete Genomics, Inc. Stepwise sequencing by non-labeled reversible terminators or natural nucleotides
WO2018127545A1 (en) 2017-01-05 2018-07-12 Evaxion Biotech Aps Vaccines targeting pseudomonas aeruginosa
WO2018127786A1 (en) 2017-01-06 2018-07-12 Oslo Universitetssykehus Hf Compositions and methods for determining a treatment course of action
EP3568493B1 (en) 2017-01-10 2021-03-24 Paragon Genomics, Inc. Methods and compositions for reducing redundant molecular barcodes created in primer extension reactions
US10329620B2 (en) 2017-01-12 2019-06-25 Cardioforecast Ltd. Methods and kits for treating cardiovascular disease
EP4050113A1 (en) 2017-01-17 2022-08-31 Life Technologies Corporation Compositions and methods for immune repertoire sequencing
CN110392736A (zh) 2017-01-18 2019-10-29 耶达研究及发展有限公司 遗传修饰的反抑细胞及其在免疫治疗中的用途
BR112019014651A2 (pt) 2017-01-18 2020-07-21 Illumina, Inc. métodos para sequenciar moléculas de ácido nucleico e para preparar adaptadores de sequenciamento, produto de programa de computador, e, sistema de computador.
CA3050984A1 (en) 2017-01-20 2018-07-26 Decipher Biosciences, Inc. Molecular subtyping, prognosis, and treatment of bladder cancer
EP3571321A1 (en) * 2017-01-23 2019-11-27 Regeneron Pharmaceuticals, Inc. Hydroxysteroid 17-beta dehydrogenase 13 (hsd17b13) variants and uses thereof
WO2018136856A1 (en) 2017-01-23 2018-07-26 Massachusetts Institute Of Technology Multiplexed signal amplified fish via splinted ligation amplification and sequencing
WO2018140391A1 (en) 2017-01-24 2018-08-02 The Broad Institute, Inc. Compositions and methods for detecting a mutant variant of a polynucleotide
CN110462062A (zh) 2017-01-26 2019-11-15 俄克拉荷马医学研究基金会 系统性红斑狼疮疾病活动性、强度和急性发作的生物标志物
MA52555A (fr) 2017-01-30 2021-03-17 Astrazeneca Ab Modulateurs du récepteur des oestrogènes
MX2019008989A (es) 2017-01-30 2019-10-09 Janssen Biotech Inc Anticuerpos anti-tnf, composiciones y metodos para el tratamiento de la artritis psoriasica activa.
GB201701719D0 (en) 2017-02-02 2017-03-22 Neumann Diagnostics Ltd Method of assessing risk
IL250479A0 (en) 2017-02-06 2017-03-30 Sorek Rotem Genetically engineered cells expressing a disarm system that confers resistance to phages and methods for their production
EP3580341A4 (en) 2017-02-09 2020-11-04 Indapta Therapeutics, Inc. MANIPULATED NATURAL KILLER (NK) CELLS AND COMPOSITIONS AND METHOD FOR THEREFORE
US20200063127A1 (en) 2017-02-15 2020-02-27 Massachusetts Institute Of Technology Dna writers, molecular recorders and uses thereof
GB201702500D0 (en) 2017-02-16 2017-04-05 Univ Sheffield Stable vamp reporter assay
CN110382690A (zh) 2017-02-16 2019-10-25 生物辐射实验室股份有限公司 新型逆转录酶及其用途
WO2018156352A1 (en) 2017-02-21 2018-08-30 Apdn (B.V.I) Inc. Nucleic acid coated submicron particles for authentication
IL250799A0 (en) 2017-02-26 2017-04-30 The Nat Inst For Biotechnology In The Negev Ltd Soluble chimeras of dr3 and pro-pilot ether and their use
IL250916A0 (en) 2017-03-02 2017-06-29 Geiger Benjamin Methods for growing t cells in culture and their use
CN110603329B (zh) 2017-03-02 2023-12-05 优美佳肿瘤技术有限公司 用于诊断肝细胞癌和肺癌的甲基化标志物
JP2020510023A (ja) 2017-03-09 2020-04-02 ダイアメディカ， インコーポレイテッド 組織カリクレイン１の剤形
EP3593140A4 (en) 2017-03-09 2021-01-06 Decipher Biosciences, Inc. SUBTYPING PROSTATE CANCER TO PREDICT RESPONSE TO HORMONE THERAPY
US11746381B2 (en) 2017-03-10 2023-09-05 Cancer Diagnostics Research Innvovations, LLC Methods for diagnosing and treating gastric cancer using miRNA expression
EP3596469A1 (en) 2017-03-12 2020-01-22 Yeda Research and Development Co., Ltd. Methods of diagnosing and prognosing cancer
WO2018167780A1 (en) 2017-03-12 2018-09-20 Yeda Research And Development Co. Ltd. Methods of prognosing and treating cancer
SG10202109731YA (en) 2017-03-13 2021-10-28 Poseida Therapeutics Inc Compositions and methods for selective elimination and replacement of hematopoietic stem cells
US11718860B2 (en) 2017-03-13 2023-08-08 Massachusetts Institute Of Technology Synthetic promoters
EP3596206A1 (en) 2017-03-16 2020-01-22 Pfizer Inc Tyrosine prototrophy
IL269363B2 (en) 2017-03-16 2024-02-01 Lineage Cell Therapeutics Inc Methods for measuring medical effects of treating retinal diseases
US20200016207A1 (en) 2017-03-20 2020-01-16 Baylor College Of Medicine TRANSGENIC c-MPL PROVIDES LIGAND-DEPENDENT CO-STIMULATION AND CYTOKINE SIGNALS TO TCR-ENGINEERED T CELLS
EP4053294A1 (en) 2017-03-24 2022-09-07 Life Technologies Corporation Polynucleotide adapters and methods of use thereof
EP4056716A1 (en) 2017-03-24 2022-09-14 Gen-Probe Incorporated Compositions and methods for detecting or quantifying parainfluenza virus
EP4219769A3 (en) 2017-03-25 2023-10-11 Gen-Probe Incorporated Compositions, methods and kits to detect rhinovirus nucleic acid
WO2018183918A1 (en) 2017-03-30 2018-10-04 Grail, Inc. Enhanced ligation in sequencing library preparation
EP3601604A4 (en) 2017-03-30 2021-01-06 The Board of Trustees of the Leland Stanford Junior University MULTIPLE DETECTION OF ISOTYPE-SPECIFIC ANTIBODIES
US11584958B2 (en) 2017-03-31 2023-02-21 Grail, Llc Library preparation and use thereof for sequencing based error correction and/or variant identification
WO2018183897A1 (en) 2017-03-31 2018-10-04 Grail, Inc. Higher target capture efficiency using probe extension
CN110678543B (zh) 2017-04-05 2024-04-09 耶达研究及发展有限公司 体外培养系统及其使用方法
US11427823B2 (en) 2017-04-11 2022-08-30 Arbutus Biopharma Corporation Targeted compositions
JP2020512825A (ja) 2017-04-12 2020-04-30 ファイザー・インク 条件的親和性を有する抗体およびその使用の方法
CA3059634A1 (en) 2017-04-13 2018-10-18 Senti Biosciences, Inc. Combinatorial cancer immunotherapy
US20200088732A1 (en) 2017-04-13 2020-03-19 INSERM (Institut National de la Santé et de la Recherche Mèdicale) Methods for the diagnosis and treatment of pancreatic ductal adenocarcinoma
JP6990713B2 (ja) 2017-04-14 2022-01-12 ヴェンタナ メディカル システムズ， インク． 解離した固定組織のサイズに基づいた分離
CA3059938A1 (en) 2017-04-14 2018-10-18 Kodiak Sciences Inc. Complement factor d antagonist antibodies and conjugates thereof
EP4083063A3 (en) 2017-04-18 2023-01-04 FUJIFILM Cellular Dynamics, Inc. Antigen-specific immune effector cells
CN110913898B (zh) 2017-04-18 2024-04-05 阿尔尼拉姆医药品有限公司 具有乙肝病毒(hbv)感染的受试者的治疗方法
CN110520196A (zh) 2017-04-19 2019-11-29 艾洛基治疗公司 改进的t细胞组合物和方法
US10995369B2 (en) 2017-04-23 2021-05-04 Illumina, Inc. Compositions and methods for improving sample identification in indexed nucleic acid libraries
AU2018259202B2 (en) 2017-04-23 2022-03-24 Illumina Cambridge Limited Compositions and methods for improving sample identification in indexed nucleic acid libraries
US10934584B2 (en) 2017-04-23 2021-03-02 Illumina, Inc. Compositions and methods for improving sample identification in indexed nucleic acid libraries
CA3059840C (en) 2017-04-23 2022-04-26 Illumina Cambridge Limited Compositions and methods for improving sample identification in indexed nucleic acid libraries
US11572591B2 (en) 2017-04-26 2023-02-07 The Translational Genomics Research Institute Methods and assays for subtyping Staphylococcus aureus clonal complex 8 strains
CA3220983A1 (en) 2017-05-01 2018-11-08 Illumina, Inc. Optimal index sequences for multiplex massively parallel sequencing
US11072816B2 (en) 2017-05-03 2021-07-27 The Broad Institute, Inc. Single-cell proteomic assay using aptamers
WO2018202792A1 (en) 2017-05-04 2018-11-08 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for the prediction of acute respiratory distress syndrome
US20200191771A1 (en) 2017-05-05 2020-06-18 bioMérieux Method for detecting an immune cellular response
IL252151A0 (en) 2017-05-07 2017-07-31 Fainzilber Michael Treatment of stress disorders
US11028436B2 (en) 2017-05-08 2021-06-08 Illumina, Inc. Universal short adapters for indexing of polynucleotide samples
CN110831966A (zh) 2017-05-10 2020-02-21 阿里埃勒科学创新有限公司 纯化抗体的方法
CA3062075C (en) 2017-05-11 2024-04-02 Gen-Probe Incorporated Compositions and methods for isolating target nucleic acids
WO2018205035A1 (en) 2017-05-12 2018-11-15 Genomedx Biosciences, Inc Genetic signatures to predict prostate cancer metastasis and identify tumor agressiveness
US11445692B2 (en) 2017-05-15 2022-09-20 Equi-Nom Ltd. Quantitative trait loci (QTL) associated with shatter resistant capsules in sesame and uses thereof
EP3625248A4 (en) 2017-05-18 2021-01-20 The Rockefeller University COMPOSITIONS AND METHODS OF DIAGNOSIS AND TREATMENT OF DISEASES AND DISEASES ASSOCIATED WITH KCNJ5 MUTATIONS
WO2018213803A1 (en) 2017-05-19 2018-11-22 Neon Therapeutics, Inc. Immunogenic neoantigen identification
US11714089B2 (en) 2017-05-21 2023-08-01 The Medical Research, Infrastructure and Health Services Fund of the Tel Aviv Medical Center Combination of markers for diagnosing cancer
EP3635402B1 (en) 2017-05-22 2024-01-24 Edith Cowan University Biomarker of disease
PT3630136T (pt) 2017-05-22 2021-06-11 4D Pharma Res Ltd Composições que compreendem estirpes bacterianas
WO2018217625A1 (en) 2017-05-23 2018-11-29 Bio-Rad Laboratories, Inc. Molecular barcoding
EP3634991A1 (en) 2017-05-23 2020-04-15 Technion Research & Development Foundation Limited Agents which inhibit gads dimerization and methods of use thereof
EP3631016A1 (en) 2017-05-24 2020-04-08 Genincode UK, Ltd. Cancer-associated venous thromboembolic events
MA41708A (fr) 2017-05-24 2020-04-08 4D Pharma Res Ltd Compositions comprenant des souches bactériennes
US20190093155A1 (en) 2017-05-25 2019-03-28 Roche Molecular Systems, Inc. Multiplex Nucleic Acid Amplification Assay
EP3631012B1 (en) 2017-05-26 2022-06-08 AbVitro LLC High-throughput polynucleotide library sequencing and transcriptome analysis
GB201708662D0 (en) 2017-05-31 2017-07-12 Tropic Biosciences Uk Ltd Compositions and methods for increasing shelf-life of banana
GB201708665D0 (en) 2017-05-31 2017-07-12 Tropic Biosciences Uk Ltd Compositions and methods for increasing extractability of solids from coffee beans
EP3630973A1 (en) 2017-05-31 2020-04-08 Tropic Biosciences UK Limited Methods of selecting cells comprising genome editing events
TWI790120B (zh) 2017-06-02 2023-01-11 美商輝瑞大藥廠 對flt3具特異性之抗體及其用途
CN110914448A (zh) 2017-06-02 2020-03-24 昂飞股份有限公司 使用差异性标记的等位基因特异性探针分析混合样品的基于阵列的方法
EP3630837A1 (en) 2017-06-02 2020-04-08 Pfizer Inc Chimeric antigen receptors targeting flt3
US11441174B2 (en) 2017-06-02 2022-09-13 Affymetrix, Inc. Array-based methods for analysing mixed samples using differently labelled allele-specific probes
JOP20190280A1 (ar) 2017-06-02 2019-12-02 Janssen Pharmaceutica Nv مثبطات fgfr2 لعلاج سرطان الأوعية الصفراوية
MX2019014480A (es) 2017-06-02 2020-01-23 Pfizer Proteinas recombinantes robo2, composiciones, metodos y usos de las mismas.
EP4276201A3 (en) 2017-06-07 2024-01-17 Gen-Probe Incorporated Detecting babesia species nucleic acid in a sample
WO2018224861A1 (en) 2017-06-07 2018-12-13 International Rice Research Institute Increasing hybrid seed production through higher outcrossing rate in cytoplasmic male sterile gramineae plants and related materials and methods
EP4293122A3 (en) 2017-06-07 2024-01-24 Oregon Health & Science University Single cell whole genome libraries for methylation sequencing
JP7270557B2 (ja) 2017-06-09 2023-05-10 ファイザー・インク 抗ｒｏｂｏ２抗体、組成物、方法、およびその使用
WO2018229764A1 (en) 2017-06-13 2018-12-20 Yeda Research And Development Co. Ltd. Treatment of advanced or progressive multiple sclerosis
LT3638271T (lt) 2017-06-14 2021-01-11 4D Pharma Research Limited Kompozicijos, apimančios bakterines padermes
RS60910B1 (sr) 2017-06-14 2020-11-30 4D Pharma Res Ltd Kompozicije koje sadrže bakterijski soj roda megasphaera i njihove upotrebe
US20180363044A1 (en) 2017-06-14 2018-12-20 Roche Molecular Systems, Inc. Compositions and methods for improving the thermal stability of nucleic acid amplification reagents
US11542540B2 (en) 2017-06-16 2023-01-03 Life Technologies Corporation Control nucleic acids, and compositions, kits, and uses thereof
EP3642362A1 (en) 2017-06-20 2020-04-29 Illumina, Inc. Methods and compositions for addressing inefficiencies in amplification reactions
EP3655418A4 (en) 2017-06-22 2021-05-19 Triact Therapeutics, Inc. METHOD OF TREATMENT OF GLIOBLASTOMA
US11618891B2 (en) 2017-06-26 2023-04-04 Thermo Fisher Scientific Baltics Uab Thermophilic DNA polymerase mutants
CN110996983A (zh) 2017-06-26 2020-04-10 巴斯德研究所 清除hiv储库并降低病毒载量的治疗
US11384075B2 (en) 2017-06-27 2022-07-12 Janssen Pharmaceutica Nv Quinolinone compounds
WO2019006392A1 (en) 2017-06-30 2019-01-03 Life Technologies Corporation LIBRARY PREPARATION METHODS AND COMPOSITIONS AND USES THEREOF
AU2018300000B2 (en) 2017-07-10 2021-11-11 Gen-Probe Incorporated Analytical systems and methods for nucleic acid amplification using sample assigning parameters
US20200131555A1 (en) 2017-07-11 2020-04-30 Synthorx, Inc. Incorporation of unnatural nucleotides and methods thereof
MX2020000366A (es) 2017-07-13 2020-08-17 Radici Chimica S P A Métodos biológicos para la modificación de flujo de carbono celular.
US11466323B2 (en) 2017-07-13 2022-10-11 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Dual-probe digital droplet PCR strategy for specific detection of tissue-specific circulating DNA molecules
EP3652342A1 (en) 2017-07-13 2020-05-20 Yissum Research and Development Company of the Hebrew University of Jerusalem Ltd. Detecting tissue-specific dna
WO2019012543A1 (en) 2017-07-13 2019-01-17 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. DNA TARGETS AS SPECIFIC TISSUE METHYLATION MARKERS
BR112020000952A2 (pt) 2017-07-15 2020-07-14 Aleph Farms composições de carne cultivada
US10760137B2 (en) 2017-07-18 2020-09-01 Roche Molecular Systems, Inc. Compositions and methods for detection of Babesia
US20190316101A1 (en) 2017-07-18 2019-10-17 Howard Hughes Medical Institute Methods and compositions for genetically manipulating genes and cells
WO2019017680A2 (ko) 2017-07-19 2019-01-24 국민대학교 산학협력단 파킨슨병 바이오마커로서의 miRNA 및 이를 이용한 진단키트
US20190048073A1 (en) 2017-07-20 2019-02-14 Pfizer Inc. Anti-gd3 antibodies and antibody-drug conjugates
US11739386B2 (en) 2017-07-21 2023-08-29 Genecentric Therapeutics, Inc. Methods for determining response to PARP inhibitors
IL253642A0 (en) 2017-07-24 2017-09-28 Seger Rony Combined treatment for cancer
US11174511B2 (en) 2017-07-24 2021-11-16 Dana-Farber Cancer Institute, Inc. Methods and compositions for selecting and amplifying DNA targets in a single reaction mixture
WO2019023291A2 (en) 2017-07-25 2019-01-31 Dana-Farber Cancer Institute, Inc. COMPOSITIONS AND METHODS FOR PRODUCTION AND DECODING OF GUIDE RNA LIBRARIES AND USES THEREOF
EP3658577A1 (en) 2017-07-27 2020-06-03 Novartis AG Sheddase resistant trem2 variants
WO2019027869A1 (en) 2017-07-31 2019-02-07 Massachusetts Institute Of Technology RNA-CLUSTER INDUCED TRANSCRIPT STABILIZER AND USES THEREOF
NZ761655A (en) 2017-07-31 2024-03-22 Reflection Biotechnologies Ltd Cellular models of and therapies for ocular diseases
WO2019027414A1 (en) 2017-07-31 2019-02-07 Massachusetts Institute Of Technology HIGH PERFORMANCE MULTIPLE INPUT MICRO-RNA DETECTORS AND USES THEREOF
EP3545106B1 (en) 2017-08-01 2022-01-19 Helitec Limited Methods of enriching and determining target nucleotide sequences
SG11202000939PA (en) 2017-08-03 2020-02-27 Synthorx Inc Cytokine conjugates for the treatment of proliferative and infectious diseases
CN111163783A (zh) 2017-08-08 2020-05-15 美国政府卫生与公众服务部 抑制hiv-1逆转录酶的组合物和方法
CA3072334A1 (en) 2017-08-09 2019-02-14 Bioverativ Therapeutics Inc. Nucleic acid molecules and uses thereof
AU2018316218A1 (en) 2017-08-11 2020-03-05 Gen-Probe Incorporated Compositions and methods for detecting Staphylococcus aureus
SG11202000839TA (en) 2017-08-14 2020-02-27 Epizyme Inc Methods of treating cancer by inhibiting setd2
US11898187B2 (en) 2017-08-15 2024-02-13 Northwestern University Protein glycosylation sites by rapid expression and characterization of N-glycosyltransferases
EP3684811A2 (en) 2017-08-17 2020-07-29 Massachusetts Institute of Technology Multiple specificity binders of cxc chemokines and uses thereof
SG11202001441WA (en) 2017-08-18 2020-03-30 Tragara Pharmaceuticals Inc Polymorphic form of tg02
AU2018317902A1 (en) 2017-08-18 2020-03-05 Sera Prognostics, Inc. Pregnancy clock proteins for predicting due date and time to birth
WO2019038771A1 (en) 2017-08-23 2019-02-28 Technion Research & Development Foundation Limited COMPOSITIONS AND METHODS FOR ENHANCING ALCOHOL TOLERANCE IN YEAST
WO2019043656A1 (en) 2017-09-01 2019-03-07 Genus Plc METHODS AND SYSTEMS FOR ASSESSING AND / OR QUANTIFYING POPULATIONS OF SPERMATOZOIDS WITH SEXUAL ASYMMETRY
EP3676399B1 (en) 2017-09-01 2022-05-11 Life Technologies Corporation Compositions and methods for immune repertoire sequencing
CN111212562B (zh) 2017-09-01 2023-06-27 奥驰亚客户服务有限公司 与烟草中提高的氮利用效率有关的方法和组合物
EP3679370A1 (en) 2017-09-07 2020-07-15 Juno Therapeutics, Inc. Methods of identifying cellular attributes related to outcomes associated with cell therapy
CN111727256A (zh) 2017-09-08 2020-09-29 波赛达治疗公司 用于嵌合配体受体（clr）-介导的条件性基因表达的组合物和方法
US20200262879A1 (en) 2017-09-11 2020-08-20 Insideoutbio, Inc. Methods and compositions to enhance the immunogenicity of tumors
US11267822B2 (en) 2017-09-13 2022-03-08 The Regents Of The University Of Michigan BET bromodomain protein degraders with cleavable linkers
US20200263170A1 (en) 2017-09-14 2020-08-20 Grail, Inc. Methods for preparing a sequencing library from single-stranded dna
US11447818B2 (en) 2017-09-15 2022-09-20 Illumina, Inc. Universal short adapters with variable length non-random unique molecular identifiers
EP3684929A1 (en) 2017-09-19 2020-07-29 Tropic Biosciences UK Limited Modifying the specificity of non-coding rna molecules for silencing gene expression in eukaryotic cells
EP3684896A1 (en) 2017-09-20 2020-07-29 Novogy, Inc. Heterologous production of 10-methylstearic acid by cells expressing recombinant methyltransferase
TW201922780A (zh) 2017-09-25 2019-06-16 美商健生生物科技公司 以抗ｉｌ１２／ｉｌ２３抗體治療狼瘡之安全且有效之方法
US11624095B2 (en) 2017-09-27 2023-04-11 Case Western Reserve University Method of quantifying HIV reservoirs by induced transcription based sequencing
WO2019067973A1 (en) 2017-09-28 2019-04-04 Grail, Inc. ENRICHMENT OF SHORT NUCLEIC ACID FRAGMENTS IN THE PREPARATION OF SEQUENCING LIBRARIES
JP2020534859A (ja) 2017-09-29 2020-12-03 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル 緑膿菌による肺定着／感染の発現リスクを予測する方法
US11628144B2 (en) 2017-09-29 2023-04-18 Triact Therapeutics, Inc. Iniparib formulations and uses thereof
WO2019063661A1 (en) 2017-09-29 2019-04-04 Roche Diagnostics Gmbh COMPOSITIONS AND METHODS FOR THE DETECTION OF TRICHOMONAS VAGINALIS
CA3074510A1 (en) 2017-10-03 2019-04-11 The Regents Of The University Of Colorado Method for differentiating cannabis plant cultivars based on cannabinoid synthase paralogs
US11634757B2 (en) 2017-10-20 2023-04-25 Stilla Technologies Emulsions with improved stability
JP7319973B2 (ja) 2017-10-31 2023-08-02 エフ． ホフマン－ラ ロシュ アーゲー 改良された磁性粒子およびその使用
WO2019089982A1 (en) 2017-11-01 2019-05-09 Juno Therapeutics, Inc. Method of assessing activity of recombinant antigen receptors
CA3079096A1 (en) 2017-11-01 2019-05-09 Allogene Therapeutics, Inc. Modified caspase-9 polypeptides and methods of use thereof
EP3704247B1 (en) 2017-11-02 2023-01-04 Bio-Rad Laboratories, Inc. Transposase-based genomic analysis
JP2021501594A (ja) 2017-11-03 2021-01-21 インテアールエヌエー テクノロジーズ ビー．ヴイ．ＩｎｔｅＲＮＡ Ｔｅｃｈｎｏｌｏｇｉｅｓ Ｂ．Ｖ． ニューロンの欠損に関連する状態及び／又は疾患を処置及び／又は診断するため、或いはニューロンの再生／発生のための、ｍｉＲＮＡ分子、等価物、アンタゴミル、又はそれらの供給源
CN111372584A (zh) 2017-11-03 2020-07-03 奥瑞基尼探索技术有限公司 Tim-3和pd-1途径的双重抑制剂
CN111386128A (zh) 2017-11-06 2020-07-07 奥瑞基尼探索技术有限公司 用于免疫调节的联合疗法
EP3707278A1 (en) 2017-11-09 2020-09-16 Alnylam Pharmaceuticals Inc. Assays and methods for determining expression of the lect2 gene
US11673921B2 (en) 2017-11-10 2023-06-13 Northwestern University Cell-free protein synthesis platform derived from cellular extracts of Vibrio natriegens
EP3710601A1 (en) 2017-11-13 2020-09-23 Life Technologies Corporation Compositions, methods and kits for urinary tract microorganism detection
IL255664A0 (en) 2017-11-14 2017-12-31 Shachar Idit Hematopoietic stem cells with enhanced properties
WO2019099610A1 (en) 2017-11-16 2019-05-23 Alnylam Pharmaceuticals, Inc. Kisspeptin 1 (kiss1) irna compositions and methods of use thereof
WO2019099629A1 (en) 2017-11-17 2019-05-23 Gen-Probe Incorporated COMPOSITIONS AND METHODS FOR DETECTING C1orf43 NUCLEIC ACID
AU2018368968A1 (en) 2017-11-17 2020-06-18 Oms Investments, Inc. Plants comprising herbicide-resistant event sequences, plant materials, and methods for detection thereof
WO2019100039A1 (en) 2017-11-20 2019-05-23 Alnylam Pharmaceuticals, Inc. Serum amyloid p component (apcs) irna compositions and methods of use thereof
CA3078981A1 (en) 2017-11-21 2019-05-31 Rgenix, Inc. Polymorphs and uses thereof
AU2018370904B2 (en) 2017-11-24 2023-09-21 Janssen Pharmaceutica Nv Pyrazolopyridinone compounds
US11078534B2 (en) 2017-11-27 2021-08-03 Roche Molecular Systems, Inc. Photocleavable nucleotide reagents with high stability
WO2019106667A1 (en) 2017-11-29 2019-06-06 Weedout Ltd. Compositions, kits and methods for controlling weed of the amaranthus genus
BR112020010753A2 (pt) 2017-12-01 2020-11-24 The Regents Of The University Of California anticorpos anti-cxcr5 e composições e usos dos mesmos
WO2019106126A1 (en) 2017-12-01 2019-06-06 INSERM (Institut National de la Santé et de la Recherche Médicale) Mdm2 modulators for the diagnosis and treatment of liposarcoma
EP3716993A1 (en) 2017-12-03 2020-10-07 Yeda Research and Development Co. Ltd Treatment of an ischemic heart disease
US10724017B1 (en) 2017-12-06 2020-07-28 Cepheid Inhibition of DNA polymerases by uracil-DNA glycosylase-cleavable oligonucleotide ligands
US10724083B1 (en) 2017-12-06 2020-07-28 Cepheid Inhibition of nucleic acid polymerases by endonuclease V-cleavable oligonucleotide ligands
US10689629B1 (en) 2017-12-06 2020-06-23 Cepheid Inhibition of nucleic acid polymerases by endonuclease V-cleavable circular oligonucleotide ligands
US11814686B2 (en) 2017-12-07 2023-11-14 Institut National de la Santéde la Recherche Médicale Method for screening and treating a subject for a cancer
UY38003A (es) 2017-12-12 2019-06-28 Amgen Inc Construcciones de arni para inhibir la expresión de pnpla3 y métodos de uso de las mismas
US10648025B2 (en) 2017-12-13 2020-05-12 Exact Sciences Development Company, Llc Multiplex amplification detection assay II
WO2019118735A1 (en) 2017-12-15 2019-06-20 Gen-Probe Incorporated Compositions and methods for detecting toxigenic clostridium difficile
EP3723785A1 (en) 2017-12-17 2020-10-21 Yeda Research and Development Co. Ltd Cop9 signalosome (csn) complex modulators and uses thereof
MX2020006012A (es) 2017-12-18 2020-09-14 Alnylam Pharmaceuticals Inc Composiciones de arni de la caja 1 del grupo de alta movilidad (hmgb1) y métodos de uso de las mismas.
EP3728305A1 (en) 2017-12-20 2020-10-28 Poseida Therapeutics, Inc. Vcar compositions and methods for use
US20190237161A1 (en) 2017-12-22 2019-08-01 Grail, Inc. Error removal using improved library preparation methods
EP3505181B1 (en) 2017-12-28 2021-07-07 Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center Preparation of enzyme replacement therapy for mucopolysaccharidosis iiid
EP3731965A1 (en) 2017-12-28 2020-11-04 Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. Method to reproduce circadian rhythms on a microfluidic chip
KR102369388B1 (ko) 2018-01-05 2022-03-02 주식회사 씨젠 시료에서 M. tuberculosis, M. bovis 및 M. bovis BCG의 존재 또는 부존재를 결정하는 방법
WO2019145956A1 (en) 2018-01-25 2019-08-01 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Methods for improved immunotherapy
US20210071242A1 (en) 2018-01-29 2021-03-11 Gen-Probe Incorporated Analytical systems and methods
IL257225A (en) 2018-01-29 2018-04-09 Yeda Res & Dev Treatment of sarcoma
JP2021517825A (ja) 2018-01-30 2021-07-29 チルドレンズ メディカル センター コーポレーションＣｈｉｌｄｒｅｎ’Ｓ Ｍｅｄｉｃａｌ Ｃｅｎｔｅｒ Ｃｏｒｐｏｒａｔｉｏｎ Ｂａｃｉｌｌｕｓ系を用いたボツリヌスニューロトキシンの生産
CN111699253A (zh) 2018-01-31 2020-09-22 生物辐射实验室股份有限公司 用于解卷积分区条码的方法和组合物
IL257269A (en) 2018-01-31 2018-04-09 Olender Tsviya Signaling is directed to the endoplasmic reticulum
WO2019152747A1 (en) 2018-01-31 2019-08-08 Juno Therapeutics, Inc. Methods and reagents for assessing the presence or absence of replication competent virus
JP2021512126A (ja) 2018-02-01 2021-05-13 バイオベラティブ セラピューティクス インコーポレイテッド 第ｖｉｉｉ因子を発現するレンチウイルスベクターの使用
US11377500B2 (en) 2018-02-01 2022-07-05 Pfizer Inc. Antibodies specific for CD70 and their uses
KR20200128018A (ko) 2018-02-01 2020-11-11 화이자 인코포레이티드 Cd70을 표적으로 하는 키메라 항원 수용체
WO2019155465A1 (en) 2018-02-08 2019-08-15 Yeda Research And Development Co. Ltd. Methods of identifying and using agents for treating diseases associated with intestinal barrier dysfunction
CN113874711A (zh) 2018-02-08 2021-12-31 菲诺法特公司 用于实时细胞监测的装置和方法
EP3749783A1 (en) 2018-02-09 2020-12-16 Genincode UK, Ltd. Prediction of pregnancy loss
WO2019159184A1 (en) 2018-02-18 2019-08-22 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Cell free dna deconvolution and use thereof
EP3755340A4 (en) 2018-02-23 2021-11-17 Carmel-Haifa University Economic Corporation Ltd. METHODS OF TREATING MEMORY DISORDER AND COGNITIVE DYSFUNCTION
WO2019167047A1 (en) 2018-02-28 2019-09-06 The Medical Research, Infrastructure and Health Services Fund of the Tel Aviv Medical Center Methods of diagnosing and treating bladder cancer
BR112020016859A2 (pt) 2018-02-28 2020-12-29 Pfizer Inc. Variantes de il-15 e usos da mesma
US11001618B2 (en) 2018-03-02 2021-05-11 Northwestern University Overexpression of FOXC1 to treat corneal vascularization
EP3762015A4 (en) 2018-03-05 2022-04-27 Janssen Biotech, Inc. METHODS OF TREATING CROHN'S DISEASE WITH SPECIFIC ANTI-IL23 ANTIBODY
WO2019175869A1 (en) 2018-03-12 2019-09-19 Yeda Research And Development Co. Ltd Treatment of a heart disease
WO2019175885A1 (en) 2018-03-15 2019-09-19 Biond Biologics Ltd. Methods and compositions for decreasing soluble immune receptor cd28
CN112119156A (zh) 2018-03-16 2020-12-22 杰傲湃思实验有限责任公司 个体化检测癌症复发或转移和/或评估治疗反应的方法
CN111868238A (zh) 2018-03-21 2020-10-30 豪夫迈·罗氏有限公司 用于甲基化-dNTPs的效率高的和有效参入的DNA聚合酶
EP3775269A1 (en) 2018-03-26 2021-02-17 Qiagen Sciences LLC Integrative dna and rna library preparations and uses thereof
CN112154153A (zh) 2018-03-28 2020-12-29 百时美施贵宝公司 白介素-2/白介素-2受体α融合蛋白以及使用方法
IL258467A (en) 2018-03-29 2018-07-04 Ilana Kolodkin Gal Methods of disrupting a biofilm and/or preventing formation of same
EP3774047A1 (en) 2018-03-29 2021-02-17 Yeda Research and Development Co. Ltd Use of electric field gradients to control gene expression
US20210017584A1 (en) 2018-03-29 2021-01-21 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for predicting the risk of developing pulmonary colonization/infection by pseudomonas aeruginosa
US11648260B2 (en) 2018-03-29 2023-05-16 Technion Research And Development Foundation Limitted Vesicles comprising a PTEN inhibitor and uses of same
PE20211235A1 (es) 2018-03-29 2021-07-08 Univ California Variantes de lfa3 y composiciones y usos de las mismas
TWI790370B (zh) 2018-04-02 2023-01-21 美商必治妥美雅史谷比公司 抗trem-1抗體及其用途
AU2019248635B2 (en) 2018-04-02 2022-01-27 Illumina, Inc. Compositions and methods for making controls for sequence-based genetic testing
US20210154270A1 (en) 2018-04-12 2021-05-27 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Anti-aging compositions and methods of use
US11725224B2 (en) 2018-04-16 2023-08-15 Northwestern University Methods for co-activating in vitro non-standard amino acid (nsAA) incorporation and glycosylation in crude cell lysates
FR3080185A1 (fr) 2018-04-16 2019-10-18 Biomerieux Evaluation du risque de complication chez un patient suspecte d'avoir une infection ayant un score sofa inferieur a deux
WO2019202536A1 (en) 2018-04-18 2019-10-24 St. Jude Children's Research Hospital Genotyping assays to identify mutations in xaf1
EP3784787A1 (en) 2018-04-27 2021-03-03 Pioneer Hi-Bred International, Inc. Maize event dp-023211-2 and methods for detection thereof
WO2019211320A1 (en) 2018-05-01 2019-11-07 Orfoneuro Aps Treatment of neuronal ceroid lipofuscinosis
GB201807192D0 (en) 2018-05-01 2018-06-13 Tropic Biosciences Uk Ltd Compositions and methods for reducing caffeine content in coffee beans
TW202016304A (zh) 2018-05-14 2020-05-01 美商阿尼拉製藥公司 血管收縮素原（ＡＧＴ）ｉＲＮＡ組成物及其使用方法
IL259392A (en) 2018-05-15 2018-08-01 Yeda Res & Dev Vaccination with cancer neo-antigens
WO2019220441A1 (en) 2018-05-15 2019-11-21 Hadasit Medical Research Services And Development Ltd. Compositions and methods for treating cancer resistant to an anti-cancer agent
US20210214793A1 (en) 2018-05-16 2021-07-15 Centre Hospitalier Régional Et Universitaire De Brest Blood biomarkers of stroke
WO2019222036A1 (en) 2018-05-18 2019-11-21 Insideoutbio, Inc. Genetically engineered argonaute proteins with enhanced gene silencing activity and methods of use thereof
US20190375822A1 (en) 2018-05-18 2019-12-12 Bioverativ Therapeutics Inc. Methods of treating hemophilia a
KR20230146098A (ko) 2018-05-23 2023-10-18 화이자 인코포레이티드 GUCY2c에 특이적인 항체 및 이의 용도
WO2019224715A1 (en) 2018-05-23 2019-11-28 Pfizer Inc. Antibodies specific for cd3 and uses thereof
MX2020012717A (es) 2018-05-25 2021-07-15 Arca Biopharma Inc Métodos y composiciones con bucindolol para el tratamiento de la fibrilación auricular.
EP3802880A1 (en) 2018-05-25 2021-04-14 Illumina, Inc. Circulating rna signatures specific to preeclampsia
MX2020012534A (es) 2018-05-27 2021-04-28 Biolinerx Ltd Agi-134 combinado con un inhibidor de punto de control para el tratamiento de tumores solidos.
US11384376B2 (en) 2018-05-31 2022-07-12 Roche Molecular Systems, Inc. Reagents and methods for post-synthetic modification of nucleic acids
US11814750B2 (en) 2018-05-31 2023-11-14 Personalis, Inc. Compositions, methods and systems for processing or analyzing multi-species nucleic acid samples
WO2020040840A2 (en) 2018-06-01 2020-02-27 Northwestern University Expanding the chemical substrates for genetic code reprogramming
WO2019236417A1 (en) 2018-06-04 2019-12-12 Biogen Ma Inc. Anti-vla-4 antibodies having reduced effector function
CN112424365A (zh) 2018-06-07 2021-02-26 以色列国家农业部、农村发展农业研究组织·沃尔卡尼中心 核酸构建体及其使用方法
CN112384063A (zh) 2018-06-07 2021-02-19 以色列国家农业部、农村发展农业研究组织·沃尔卡尼中心 再生及转殖大麻的方法
WO2019234221A1 (en) 2018-06-08 2019-12-12 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for stratification and treatment of a patient suffering from chronic lymphocytic leukemia
GB2597566B (en) 2018-06-13 2023-02-01 Gen Probe Inc Compositions and methods for detecting group B streptococcus nucleic acid
US11873322B2 (en) 2018-06-25 2024-01-16 Yeda Research And Development Co. Ltd. Systems and methods for increasing efficiency of genome editing
JP2021528094A (ja) 2018-06-29 2021-10-21 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ マイクロサテライト不安定性の検出
US20210292381A1 (en) 2018-07-04 2021-09-23 Ukko Inc. Methods of de-epitoping wheat proteins and use of same for the treatment of celiac disease
EP3818529A2 (en) 2018-07-08 2021-05-12 Yeda Research and Development Co. Ltd Person-specific assessment of probiotics responsiveness
EP3820616A1 (en) 2018-07-10 2021-05-19 Gen-Probe Incorporated Methods and systems for detecting and quantifying nucleic acids
SG11202013167UA (en) 2018-07-11 2021-01-28 Kahr Medical Ltd SIRPalpha-4-1BBL VARIANT FUSION PROTEIN AND METHODS OF USE THEREOF
WO2020012478A2 (en) 2018-07-11 2020-01-16 Immunity Pharma Ltd. Peptide compounds and therapeutic uses of same
WO2020012021A1 (en) 2018-07-13 2020-01-16 Varct Diagnostics Aps Isolation of circulating cells of fetal origin using recombinant malaria protein var2csa
MX2018008742A (es) 2018-07-16 2020-01-17 Sigma Alimentos Sa De Cv Metodo y kit de diagnostico para detectar multiple y simultaneamente una combinacion de bacterias gram positivas y/o bacterias gram negativas.
WO2020018715A1 (en) 2018-07-17 2020-01-23 Massachusetts Institute Of Technology Soluble multimeric immunoglobulin-scaffold based fusion proteins and uses thereof
EP3824103A1 (en) 2018-07-18 2021-05-26 Life Technologies Corporation Compositions and methods for immune repertoire sequencing
JP2021530697A (ja) 2018-07-18 2021-11-11 ヤンセン バイオテツク，インコーポレーテツド 抗ｉｌ２３特異的抗体で治療した後の持続応答予測因子
WO2020018837A1 (en) 2018-07-18 2020-01-23 Life Technologies Corporation Compositions and methods for immune repertoire sequencing
EP3823672A1 (en) 2018-07-19 2021-05-26 Institut National de la Santé et de la Recherche Médicale (INSERM) Combination for treating cancer
CN112770776A (zh) 2018-07-30 2021-05-07 瑞德库尔有限责任公司 用于样品处理或分析的方法和系统
WO2020028612A1 (en) 2018-08-01 2020-02-06 Massachusetts Institute Of Technology Rna-based regulatory technologies for mirna sensors
US20200056189A1 (en) 2018-08-01 2020-02-20 Massachusetts Institute Of Technology Phosphorylation-based mirna sensor
AU2019319203A1 (en) 2018-08-08 2021-03-11 Gen-Probe Incorporated Compositions, methods and kits for detecting
CN113227385A (zh) 2018-08-09 2021-08-06 比奥维拉迪维治疗股份有限公司 核酸分子及其用于非病毒基因疗法的用途
CN113166736A (zh) 2018-08-13 2021-07-23 奥尔胡斯大学 具有改变的激动剂特异性和亲和性的基因改变的LysM受体
TW202023574A (zh) 2018-08-13 2020-07-01 美商阿尼拉製藥公司 Ｂ型肝炎病毒（ＨＢＶ）ｄｓＲＮＡ劑組合物及其使用方法
CA3109319A1 (en) 2018-08-13 2020-02-20 Aarhus Universitet Genetically altered plants expressing heterologous receptors that recognize lipo-chitooligosaccharides
IL261156A (en) 2018-08-14 2020-02-27 Fass Deborah Chimeric quiescin sulfhydryl oxidase (qsox1) antibodies and uses of same
KR20210043634A (ko) 2018-08-15 2021-04-21 일루미나, 인코포레이티드 라이브러리 인리치먼트를 개선하기 위한 조성물 및 방법
EP3863637A1 (en) 2018-08-16 2021-08-18 Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. Treatment for gene reactivation
CN113166807A (zh) 2018-08-20 2021-07-23 生物辐射实验室股份有限公司 通过分区中条码珠共定位生成核苷酸序列
CA3109905A1 (en) 2018-08-20 2020-02-27 Pfizer Inc. Anti-gdf15 antibodies, compositions and methods of use
US20220074002A1 (en) 2018-08-21 2022-03-10 Gen-Probe Incorporated Compositions and methods for amplifying, detecting or quantifying human cytomegalovirus
US11548938B2 (en) 2018-08-21 2023-01-10 Quidel Corporation DbpA antibodies and uses thereof
EP3613855A1 (en) 2018-08-23 2020-02-26 Clariant Produkte (Deutschland) GmbH Method for the production of a nucleic acid library
WO2020039440A1 (en) 2018-08-24 2020-02-27 Yeda Research And Development Co. Ltd. Methods of modulating m2 macrophage polarization and use of same in therapy
JP7389111B2 (ja) 2018-08-24 2023-11-29 ジェン－プローブ・インコーポレーテッド 細菌の核酸を検出し、細菌性膣炎を診断するための組成物および方法
US20210317524A1 (en) 2018-08-28 2021-10-14 10X Genomics, Inc. Resolving spatial arrays
CN113366117A (zh) 2018-08-28 2021-09-07 10X基因组学股份有限公司 用于生物样品中转座酶介导的空间标记和分析基因组dna的方法
SG11202102058UA (en) 2018-08-30 2021-03-30 Tenaya Therapeutics Inc Cardiac cell reprogramming with myocardin and ascl1
JP2021536249A (ja) 2018-09-05 2021-12-27 ポセイダ セラピューティクス，インコーポレイティド 同種異系細胞組成物およびその使用方法
WO2020049106A1 (en) 2018-09-05 2020-03-12 Max-Delbrück-Centrum Für Molekulare Medizin In Der Helmholtz-Gemeinschaft A method for engineering synthetic cis-regulatory dna
EP3847277A1 (en) 2018-09-06 2021-07-14 Hygiena, LLC Sequences and their use for detection and characterization of escherichia coli serotype o157:h7
JP2022500015A (ja) 2018-09-07 2022-01-04 セクエノム， インコーポレイテッド 移植片拒絶を検出する方法およびシステム
US11408030B2 (en) 2018-09-10 2022-08-09 Andy Madrid Test for detecting Alzheimer's disease
WO2020051766A1 (zh) 2018-09-11 2020-03-19 上海市公共卫生临床中心 一种广谱抗流感疫苗免疫原及其应用
US11739306B2 (en) 2018-09-13 2023-08-29 Roche Molecular Systems, Inc. Mutant DNA polymerase(s) with improved strand displacement ability
AU2019339508A1 (en) 2018-09-14 2021-04-15 Prelude Corporation Method of selection for treatment of subjects at risk of invasive breast cancer
WO2020060948A1 (en) 2018-09-17 2020-03-26 Levadura Biotechnology, Inc. Production of cannabinoids in yeast using a fatty acid feedstock
WO2020058979A2 (en) 2018-09-20 2020-03-26 Yeda Research And Development Co. Ltd. Methods of treating amyotrophic lateral sclerosis
EP3856225A1 (en) 2018-09-25 2021-08-04 BioLineRx Ltd. Methods of selecting treatment for cxcr4-associated cancer
WO2020069029A1 (en) 2018-09-26 2020-04-02 Emendobio Inc. Novel crispr nucleases
EP3856934A2 (en) 2018-09-27 2021-08-04 Gen-Probe Incorporated COMPOSITIONS AND METHODS FOR DETECTING BORDETELLA PERTUSSIS AND BORDETELLA
PARAPERTUSSIS NUCLEIC ACID
EP3856763A1 (en) 2018-09-28 2021-08-04 Massachusetts Institute of Technology Collagen-localized immunomodulatory molecules and methods thereof
EP3861141A1 (en) 2018-10-01 2021-08-11 Gen-Probe Incorporated Compositions and methods for amplifying or detecting varicella-zoster virus
US11046703B2 (en) 2018-10-08 2021-06-29 The Regents Of The University Of Michigan Small molecule MDM2 protein degraders
CN113473990A (zh) 2018-10-08 2021-10-01 锐新医药公司 用于治疗癌症的shp2抑制剂组合物
US20210388449A1 (en) 2018-10-09 2021-12-16 Genecentric Therapeutics, Inc. Detecting cancer cell of origin
WO2020077236A1 (en) 2018-10-12 2020-04-16 The Broad Institute, Inc. Method for extracting nuclei or whole cells from formalin-fixed paraffin-embedded tissues
UY38407A (es) 2018-10-15 2020-05-29 Novartis Ag Anticuerpos estabilizadores de trem2
KR102554477B1 (ko) 2018-10-18 2023-07-11 오클라호마 메디컬 리써치 화운데이션 질병 활성도의 특징을 규명하는 전신 홍반성 낭창(sle) 질병 활성도 면역 지수를 위한 생체지표
AU2019365821A1 (en) 2018-10-22 2021-06-10 Gen-Probe Incorporated Compositions and methods for amplifying, detecting or quantifying human polyomavirus BK virus
WO2020083904A1 (en) 2018-10-22 2020-04-30 Evaxion Biotech Aps Vaccines targeting m. catharrhalis
IL262658A (en) 2018-10-28 2020-04-30 Memorial Sloan Kettering Cancer Center Prevention of age related clonal hematopoiesis and diseases associated therewith
WO2020092140A2 (en) 2018-11-02 2020-05-07 Insideoutbio, Inc. Methods and compositions to induce or suppress immune responses through the use of membrane bound complement split products
CN113227356A (zh) 2018-11-08 2021-08-06 耶路撒冷希伯来大学伊森姆研究发展有限公司 非贴附性细胞及其用途
EP4357022A2 (en) 2018-11-13 2024-04-24 The University of North Carolina at Chapel Hill Analysis systems with microfluidic devices, microfluidic devices and related methods
WO2020104482A1 (en) 2018-11-20 2020-05-28 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for predicting metastatic potential in patients suffering from sdhb-mutated paraganglioma
IL263184A (en) 2018-11-21 2020-05-31 Yarden Yosef Method of treating cancer and compositions for same
KR20210123289A (ko) 2018-11-21 2021-10-13 인답타 세라뷰틱스 인코포레이티드 자연 살해 세포 서브세트의 증식을 위한 방법 및 관련 조성물 및 방법
MX2021006234A (es) 2018-11-30 2021-09-10 Caris Mpi Inc Perfilado molecular de proxima generacion.
US20220017973A1 (en) 2018-12-03 2022-01-20 Roche Molecular Systems, Inc. Compositions and methods for detection of candida auris
AU2019392735A1 (en) 2018-12-06 2021-06-17 Wageningen Universiteit Methods of genetically altering a plant NIN-gene to be responsive to cytokinin
WO2020123309A1 (en) 2018-12-10 2020-06-18 10X Genomics, Inc. Resolving spatial arrays by proximity-based deconvolution
JOP20210142A1 (ar) 2018-12-10 2023-01-30 Amgen Inc تركيبات rnai لتثبيط التعبير الوراثي عن pnpla3 وطرق استخدامها
SG11202105441WA (en) 2018-12-13 2021-06-29 Dna Script Direct oligonucleotide synthesis on cells and biomolecules
CN113286883A (zh) 2018-12-18 2021-08-20 格里尔公司 使用rna分析以检测疾病的方法
MA54562A (fr) 2018-12-18 2021-10-27 Janssen Biotech Inc Méthode sûre et efficace de traitement du lupus avec un anticorps anti-il12/il23
TW202030333A (zh) 2018-12-20 2020-08-16 美商簡 探針公司 用於檢測瘧原蟲物種核酸之組成物及方法
BR112021012154A2 (pt) 2018-12-20 2021-09-08 Life Technologies Corporation Corante de rodamina assimétrica e uso da mesma em ensaios biológicos
WO2020127620A1 (en) 2018-12-20 2020-06-25 F. Hoffmann-La Roche Ag Detection of target nucleic acid by solid-phase molography
MX2021007494A (es) 2018-12-20 2021-10-13 Life Technologies Corp Colorante de rodamina modificado y uso del mismo en ensayos biológicos.
WO2020128033A1 (en) 2018-12-20 2020-06-25 Institut Pasteur Cellular metabolism of hiv-1 reservoir seeding in cd4+ t cells
KR20210108433A (ko) 2018-12-26 2021-09-02 얀센 파마슈티카 엔.브이. 티에노피리디논 화합물
BR112021013020A2 (pt) 2018-12-31 2021-09-14 Abbott Molecular Inc. Amplificação melhorada de ácidos nucleicos
US20220080425A1 (en) 2018-12-31 2022-03-17 Gen-Probe Incorporated Tray for transfering solid reagents to a multi-well cartridge
EP3906317A1 (en) 2019-01-03 2021-11-10 DNA Script One pot synthesis of sets of oligonucleotides
US11473136B2 (en) 2019-01-03 2022-10-18 Ncan Genomics, Inc. Linked target capture
US11926867B2 (en) 2019-01-06 2024-03-12 10X Genomics, Inc. Generating capture probes for spatial analysis
US11649485B2 (en) 2019-01-06 2023-05-16 10X Genomics, Inc. Generating capture probes for spatial analysis
EP3908823A4 (en) 2019-01-10 2022-10-12 Travera LLC CALIBRATION OF A FUNCTIONAL BIOMARKER INSTRUMENT
CA3126761C (en) 2019-01-15 2023-01-10 Seminis Vegetable Seeds, Inc. Green bean plants with improved disease resistance
SG11202107670TA (en) 2019-01-18 2021-08-30 Univ California Dna methylation measurement for mammals based on conserved loci
JP2022518242A (ja) 2019-01-22 2022-03-14 ビペルゲン エーピーエス 細胞内のインビトロディスプレイライブラリのスクリーニング方法
WO2020152686A1 (en) 2019-01-23 2020-07-30 Yeda Research And Development Co. Ltd. Culture media for pluripotent stem cells
EA202192038A1 (ru) 2019-01-23 2021-10-05 Янссен Байотек, Инк. Композиции антител к фно для применения в способах лечения псориатического артрита
JP2020117502A (ja) 2019-01-28 2020-08-06 ファイザー・インク 変形性関節症の徴候および症状を処置する方法
KR20210123299A (ko) 2019-02-06 2021-10-13 신톡스, 인크. Il-2 콘쥬게이트 및 이의 사용 방법
IL264768A (en) 2019-02-10 2020-08-31 Sagi Irit ANTI-MATRIX METALLOPROTEINASE 7 (MMP-7) inhibitory antibody and its use
IL264854A (en) 2019-02-14 2020-08-31 Bahat Anat Spt5 inhibitors and methods of use thereof
US20220117247A1 (en) 2019-02-14 2022-04-21 Dupont Nutrition Biosciences Aps Lactic acid bacterium with a reduction of sensitivity to cos-type bacteriophages
EP3927845A1 (en) 2019-02-19 2021-12-29 Sequenom, Inc. Compositions, methods, and systems to detect hematopoietic stem cell transplantation status
WO2020171889A1 (en) 2019-02-19 2020-08-27 University Of Rochester Blocking lipid accumulation or inflammation in thyroid eye disease
WO2020170239A1 (en) 2019-02-21 2020-08-27 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Methods of generating organoids for high throughput screening of drugs
JP2022521010A (ja) 2019-02-21 2022-04-04 イッスム・リサーチ・デベロプメント・カムパニー・オブ・ザ・ヘブリュー・ユニバシティー・オブ・エルサレム リミテッド 薬物誘導性腎毒性を減少させるための方法
US20220137392A1 (en) 2019-02-27 2022-05-05 Seegene, Inc. Light module
US20220143168A1 (en) 2019-02-27 2022-05-12 Evaxion Biotech A/S Vaccines targeting H. influenzae
EP3931354A1 (en) 2019-02-28 2022-01-05 10X Genomics, Inc. Profiling of biological analytes with spatially barcoded oligonucleotide arrays
AU2020232618A1 (en) 2019-03-01 2021-04-08 Illumina, Inc. High-throughput single-nuclei and single-cell libraries and methods of making and of using
EP3934417A1 (en) 2019-03-05 2022-01-12 The State of Israel - Ministry of Agriculture & Rural Development, Agricultural Research Organization (ARO) (Volcani Center) Genome-edited birds
JP7124234B2 (ja) 2019-03-08 2022-08-23 タロー・ファーマシューティカル・インダストリーズ・リミテッド フェノルドパムの安定な局所用組成物
EP3937780A4 (en) 2019-03-14 2022-12-07 InSilixa, Inc. METHODS AND SYSTEMS FOR TIMED FLUORESCENCE-BASED DETECTION
CA3133395A1 (en) 2019-03-14 2020-09-17 Janssen Biotech, Inc. Manufacturing methods for producing anti-il12/il23 antibody compositions
GB201903520D0 (en) 2019-03-14 2019-05-01 Tropic Biosciences Uk Ltd Modifying the specificity of non-coding rna molecules for silencing genes in eukaryotic cells
WO2020185298A1 (en) 2019-03-14 2020-09-17 Massachusetts Institute Of Technology Engineered herpes simplex virus-1 (hsv-1) vectors and uses thereof
GB201903519D0 (en) 2019-03-14 2019-05-01 Tropic Biosciences Uk Ltd Introducing silencing activity to dysfunctional rna molecules and modifying their specificity against a gene of interest
CA3133381A1 (en) 2019-03-14 2020-09-17 Janssen Biotech, Inc. Manufacturing methods for producing anti-tnf antibody compositions
MX2021010961A (es) 2019-03-14 2021-10-13 Dupont Nutrition Biosci Aps Nuevas bacterias del acido lactico.
CN114127309A (zh) 2019-03-15 2022-03-01 10X基因组学有限公司 使用空间阵列进行单细胞测序的方法
IL265486A (en) 2019-03-19 2020-09-30 Yeda Res & Dev Bistable type ii opsins and uses thereof
WO2020198071A1 (en) 2019-03-22 2020-10-01 10X Genomics, Inc. Three-dimensional spatial analysis
US20220098647A1 (en) 2019-03-22 2022-03-31 Gen-Probe Incorporated Compositions and Methods for Detecting Group A Streptococcus
EP3948290A4 (en) 2019-03-26 2023-08-09 Dermtech, Inc. NEW GENE CLASSIFIERS AND THEIR USES FOR SKIN CANCERS
EP3798318A1 (en) 2019-09-30 2021-03-31 Diagenode S.A. A high throughput sequencing method and kit
US20220177964A1 (en) 2019-03-27 2022-06-09 Diagenode S.A. A high throughput sequencing method and kit
WO2020194317A1 (en) 2019-03-28 2020-10-01 Yeda Research And Development Co. Ltd. Method of treating lipid-related disorders
KR20210145211A (ko) 2019-03-29 2021-12-01 얀센 파마슈티카 엔.브이. 요로상피세포암종의 치료를 위한 fgfr 티로신 키나제 저해제
EP3946611A2 (en) 2019-03-31 2022-02-09 Yeda Research and Development Co. Ltd Anti-viral and anti-tumoral compounds
US20220064731A1 (en) 2019-04-03 2022-03-03 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Primers for multiplex pcr
WO2020205491A1 (en) 2019-04-05 2020-10-08 Hygiena, Llc Sequences and their use for detection and characterization of genus cronobacter
US20200325472A1 (en) 2019-04-09 2020-10-15 Massachusetts Institute Of Technology Mutant subgenomic promoter library and uses thereof
WO2020210420A1 (en) 2019-04-09 2020-10-15 Sigma-Aldrich Co. Llc Accelerated polymerase chain reaction based on thermocycling enabled by millimeter wave heating
MX2021012671A (es) 2019-04-17 2022-01-24 Impossible Foods Inc Métodos y materiales para la producción de proteínas.
US20220220564A1 (en) 2019-04-17 2022-07-14 Igenomix, S.L. Improved methods for the early diagnosis of uterine leiomyomas and leiomyosarcomas
WO2020212992A2 (en) 2019-04-17 2020-10-22 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Cancer cell methylation markers and use thereof
SG11202111693YA (en) 2019-04-25 2021-11-29 Impossible Foods Inc Strains and methods for production of heme-containing proteins
CN113785073A (zh) 2019-05-02 2021-12-10 豪夫迈·罗氏有限公司 基于链分离温度利用dITP进行RNA靶标相比于DNA靶标的优先性/选择性扩增
IL266433B (en) 2019-05-02 2020-11-30 Sagi Irit Compositions comprising the propeptide of lysyl oxidase and uses thereof
EP3966351A1 (en) 2019-05-07 2022-03-16 F. Hoffmann-La Roche AG Compositions and methods for detection of neisseria gonorroheae
US20220220169A1 (en) 2019-05-15 2022-07-14 Insideoutbio, Inc. Modular Therapeutics for the Treatment of Inflammatory Diseases and Cancer
US20200362345A1 (en) 2019-05-17 2020-11-19 Massachusetts Institute Of Technology Engineered post-poly a signal rna and uses thereof
IL266728B (en) 2019-05-19 2020-11-30 Yeda Res & Dev Identification of recurrent mutant neopeptides
AU2020279080A1 (en) 2019-05-22 2022-01-20 Hadasit Medical Research Services And Development Ltd. Methods of culturing human pluripotent cells
US11780911B2 (en) 2019-05-23 2023-10-10 Janssen Biotech, Inc. Method of treating inflammatory bowel disease with a combination therapy of antibodies to IL-23 and TNF alpha
SG11202113112WA (en) 2019-05-30 2021-12-30 Amgen Inc Rnai constructs for inhibiting scap expression and methods of use thereof
WO2020243579A1 (en) 2019-05-30 2020-12-03 10X Genomics, Inc. Methods of detecting spatial heterogeneity of a biological sample
US20220244181A1 (en) 2019-05-31 2022-08-04 Seegene, Inc. Method for detecting target nucleic acid in sample
KR20220029593A (ko) 2019-06-03 2022-03-08 얀센 바이오테크 인코포레이티드 건선성 관절염의 치료를 위한 항-tnf 항체 조성물, 및 방법
US20220249660A1 (en) 2019-06-06 2022-08-11 Sitokine Limited Compositions and methods for treating lung, colorectal and breast cancer
IT201900008376A1 (it) 2019-06-07 2020-12-07 Univ Degli Studi Di Modena E Reggio Emilia Anticorpi ad attività antitumorale
US20220233477A1 (en) 2019-06-12 2022-07-28 Hadasit Medical Research Services And Development Ltd. Methods of generating oligodendrocytes
CA3141405A1 (en) 2019-06-12 2020-12-17 H. Charles Manning Amino acid transport inhibitors and the uses thereof
EP3983377A1 (en) 2019-06-12 2022-04-20 Vanderbilt University Dibenzylamines as amino acid transport inhibitors
WO2020251306A1 (en) 2019-06-14 2020-12-17 Seegene, Inc. Computer-implemented method for collaborative development of reagents for detection of target nucleic acids
US20220307008A1 (en) 2019-06-16 2022-09-29 Yeda Research And Development Co. Ltd. Method for stabilizing intracellular rna
US20220305107A1 (en) 2019-06-18 2022-09-29 Janssen Sciences Ireland Unlimited Company COMBINATION OF HEPATITIS B VIRUS (HBV) VACCINES AND HBV-TARGETING RNAi
JP2022538974A (ja) 2019-06-26 2022-09-07 マサチューセッツ インスチテュート オブ テクノロジー 免疫調節融合タンパク質－金属水酸化物錯体およびその方法
EP3990488A4 (en) 2019-06-27 2023-09-13 Ramot at Tel-Aviv University Ltd. SEMAPHORIN 3A ANTIBODIES AND THEIR USES
WO2020264532A1 (en) * 2019-06-28 2020-12-30 Asc Therapeutics Inc. Methods and compositions for treating thalassemia or sickle cell disease
EP3994268A1 (en) 2019-07-04 2022-05-11 Ukko Inc. De-epitoped alpha gliadin and use of same for the management of celiac disease and gluten sensitivity
BR112021026890A2 (pt) 2019-07-08 2022-03-15 Res Inst Nationwide Childrens Hospital Composições de anticorpo para interromper biofilmes
JP2022541742A (ja) 2019-07-11 2022-09-27 カール メディカル リミテッド ヘテロダイマーおよびその使用方法
US20230137971A1 (en) 2019-07-11 2023-05-04 Tenaya Therapeutics Inc. Cardiac cell reprogramming with micrornas and other factors
US20220281960A1 (en) 2019-07-16 2022-09-08 Ramot At Tel-Aviv University Ltd. Compositions and methods for the treatment of tuberculosis
US20220257653A1 (en) 2019-07-19 2022-08-18 The Children's Hospital Of Philadelphia Chimeric antigen receptors containing glypican 2 binding domains
CN114174540A (zh) 2019-07-25 2022-03-11 豪夫迈·罗氏有限公司 用于检测爱泼斯坦巴尔病毒(ebv)的组合物和方法
US11572546B2 (en) 2019-07-29 2023-02-07 Ginkgo Bioworks, Inc. Methods and compositions involving promoters derived from Yarrowia lipolytica
WO2021019526A1 (en) 2019-07-29 2021-02-04 Yeda Research And Development Co. Ltd. Methods of treating and diagnosing lung cancer
EP4004212A1 (en) 2019-07-30 2022-06-01 The State of Israel, Ministry of Agriculture & Rural Development, Agricultural Research Organization (ARO) (Volcani Institute) Methods of controlling cannabinoid synthesis in plants or cells and plants and cells produced thereby
WO2021022108A2 (en) 2019-08-01 2021-02-04 Alnylam Pharmaceuticals, Inc. CARBOXYPEPTIDASE B2 (CPB2) iRNA COMPOSITIONS AND METHODS OF USE THEREOF
WO2021022109A1 (en) 2019-08-01 2021-02-04 Alnylam Pharmaceuticals, Inc. SERPIN FAMILY F MEMBER 2 (SERPINF2) iRNA COMPOSITIONS AND METHODS OF USE THEREOF
JP7284256B2 (ja) 2019-08-12 2023-05-30 ビオンド バイオロジクス リミテッド Ｉｌｔ２に対する抗体およびその使用
EP4014046A1 (en) 2019-08-12 2022-06-22 Yeda Research and Development Co. Ltd Dna repair blood test for predicting response of lung cancer patients to immunotherapy
WO2021028469A1 (en) 2019-08-12 2021-02-18 Sitokine Limited Compositions and methods for treating cytokine release syndrome and neurotoxicity
EP4013871A1 (en) 2019-08-13 2022-06-22 Amgen Inc. Rnai constructs for inhibiting slc30a8 expression and methods of use thereof
WO2021030522A1 (en) 2019-08-13 2021-02-18 Alnylam Pharmaceuticals, Inc. SMALL RIBOSOMAL PROTEIN SUBUNIT 25 (RPS25) iRNA AGENT COMPOSITIONS AND METHODS OF USE THEREOF
WO2021028752A1 (en) 2019-08-15 2021-02-18 Janssen Biotech, Inc. Anti-tfn antibodies for treating type i diabetes
WO2021032769A1 (en) 2019-08-19 2021-02-25 Aarhus Universitet Modified exopolysaccharide receptors for recognizing and structuring microbiota
GB201911928D0 (en) 2019-08-20 2019-10-02 Otsuka Pharma Co Ltd Pharmaceutical compounds
US11788091B2 (en) 2019-08-21 2023-10-17 University Of Virginia Patent Foundation Methods and compositions for diagnosing and treating prostate cancer based on long noncoding RNA overlapping the LCK gene that regulates prostate cancer cell growth
WO2021033176A1 (en) 2019-08-22 2021-02-25 Ariel Scientific Innovations Ltd. Scaled-up methods for purifying antibodies
CA3152309A1 (en) 2019-08-23 2021-03-04 Gen-Probe Incorporated Compositions, methods and kits for detecting treponema pallidum
WO2021037399A1 (en) 2019-08-27 2021-03-04 F. Hoffmann-La Roche Ag Compositions and methods for amplification and detection of hepatitis b virus rna, including hbv rna transcribed from cccdna
EP4021463A1 (en) 2019-08-27 2022-07-06 Yeda Research and Development Co. Ltd Treatment of bacterial vaginosis
EP4022092A1 (en) 2019-08-30 2022-07-06 Life Technologies Corporation Compositions and methods for oncology precision assays
AU2020341454A1 (en) 2019-09-03 2022-03-10 Sana Biotechnology, Inc. CD24-associated particles and related methods and uses thereof
CA3149892A1 (en) 2019-09-05 2021-03-11 Eric M. Ostertag Allogeneic cell compositions and methods of use
AU2020343334A1 (en) 2019-09-05 2022-04-07 Gen-Probe Incorporated Detection of Chlamydia trachomatis nucleic acid variants
JP2022546597A (ja) 2019-09-06 2022-11-04 ジェネレーション バイオ カンパニー 閉端ｄｎａおよび切断可能脂質を含む脂質ナノ粒子組成物ならびにそれらの使用方法
WO2021048852A1 (en) 2019-09-11 2021-03-18 Yeda Research And Development Co. Ltd. Methods of treating breast cancer
CN114729346A (zh) 2019-09-13 2022-07-08 丹尼斯科美国公司 热稳定的葡萄糖异构酶变体
WO2021048400A1 (en) 2019-09-13 2021-03-18 Evaxion Biotech Aps Method for identifying t-cell epitopes
WO2021048381A1 (en) 2019-09-13 2021-03-18 Evaxion Biotech Aps Method for identifying stable mhc binding peptides using mass spectrometry
CA3150899A1 (en) 2019-09-17 2021-03-25 Luke T. Daum Multipurpose compositions for collecting and transporting biological material
TW202124446A (zh) 2019-09-18 2021-07-01 瑞士商諾華公司 與ｅｎｔｐｄ２抗體之組合療法
US20220348651A1 (en) 2019-09-18 2022-11-03 Novartis Ag Entpd2 antibodies, combination therapies, and methods of using the antibodies and combination therapies
JP2022548949A (ja) 2019-09-23 2022-11-22 イッサム リサーチ デベロップメント カンパニー オブ ザ ヘブリュー ユニバーシティー オブ エルサレム エルティーディー． 不安定なｍＲＮＡによって特徴付けられた遺伝性疾患の治療
WO2021062037A1 (en) 2019-09-24 2021-04-01 Auburn University Phage-peptide constructs for stimulation of an anti-cancer immune response against cd47
IL269674B (en) 2019-09-25 2020-08-31 Roy Bar Ziv Assembling protein complexes on a chip
US11542513B2 (en) 2019-09-26 2023-01-03 Seminis Vegetable Seeds, Inc. Lettuce plants having resistance to Nasonovia ribisnigri biotype Nr:1
WO2021062096A1 (en) 2019-09-26 2021-04-01 Massachusetts Institute Of Technology Microrna-based logic gates and uses thereof
WO2021062092A1 (en) 2019-09-26 2021-04-01 Massachusetts Institute Of Technology Trans-activated functional rna by strand displacement and uses thereof
GB201913921D0 (en) 2019-09-26 2019-11-13 Sentinel Oncology Ltd Pharmaceutical compounds
CA3155930A1 (en) 2019-09-27 2021-04-01 Starkage Therapeutics SENESCENT CELL-ASSOCIATED ANTIGEN-BINDING DOMAINS, ANTIBODIES AND CHIMERIC ANTIGEN RECEPTORS COMPRISING THEM, AND USES THEREOF
US20210113634A1 (en) 2019-09-30 2021-04-22 Bioverativ Therapeutics Inc. Lentiviral vector formulations
US11788137B2 (en) 2019-09-30 2023-10-17 Diagenode S.A. Diagnostic and/or sequencing method and kit
CN115176032A (zh) 2019-10-11 2022-10-11 生命科技股份有限公司 用于评估微生物群体的组合物和方法
WO2021072031A1 (en) 2019-10-11 2021-04-15 Insideoutbio, Inc. Methods and compositions for the manufacture and use of circular dna encoded therapeutics for genetic disorders and other diseases
EP4045652A1 (en) 2019-10-18 2022-08-24 Alnylam Pharmaceuticals, Inc. Solute carrier family member irna compositions and methods of use thereof
WO2021076346A1 (en) 2019-10-18 2021-04-22 Pioneer Hi-Bred International, Inc. Maize event dp-202216-6 and dp-023211-2 stack
CN115175680A (zh) 2019-10-18 2022-10-11 加利福尼亚大学董事会 Plxdc激活剂及其用于治疗血管病症的用途
BR112022007540A2 (pt) 2019-10-22 2022-07-12 Alnylam Pharmaceuticals Inc Composições de irna de componente complementar c3 e métodos de uso das mesmas
IL270306A (en) 2019-10-30 2021-05-31 Yeda Res & Dev Prevention and treatment of pre-myeloid and myeloid malignancies
US20240117386A1 (en) 2019-10-31 2024-04-11 Yeda Research And Development Co. Ltd. Engineered autotrophic bacteria for co2 conversion to organic materials
EP3901286A1 (en) 2020-04-24 2021-10-27 Mirnax Biosens, S.L. Bivalent reverse primer
US20220389497A1 (en) 2019-11-04 2022-12-08 Mirnax Biosens, S.L. Bivalent reverse primer
WO2021092145A1 (en) 2019-11-06 2021-05-14 Alnylam Pharmaceuticals, Inc. Transthyretin (ttr) irna composition and methods of use thereof for treating or preventing ttr-associated ocular diseases
WO2021092433A2 (en) 2019-11-08 2021-05-14 10X Genomics, Inc. Enhancing specificity of analyte binding
EP4055185A1 (en) 2019-11-08 2022-09-14 10X Genomics, Inc. Spatially-tagged analyte capture agents for analyte multiplexing
MX2022005678A (es) 2019-11-11 2022-10-18 Ibi Ag Innovative Bio Insecticides Ltd Nanocuerpos para el control de insectos y usos de los mismos.
CA3159392A1 (en) 2019-11-14 2021-05-20 Gen-Probe Incorporated Compositions and methods for capturing target nucleic acids
WO2021100034A1 (en) 2019-11-19 2021-05-27 Protalix Ltd. Removal of constructs from transformed cells
US11441167B2 (en) 2019-11-20 2022-09-13 Roche Molecular Systems, Inc. Compositions and methods for rapid identification and phenotypic antimicrobial susceptibility testing of bacteria and fungi
IL270800A (en) 2019-11-20 2021-05-31 Yeda Res & Dev A method for treating Alzheimer's disease
EP4061945A1 (en) 2019-11-22 2022-09-28 Alnylam Pharmaceuticals, Inc. Ataxin3 (atxn3) rnai agent compositions and methods of use thereof
CN113677807A (zh) 2019-11-22 2021-11-19 因美纳有限公司 先兆子痫特异性的循环rna标记
WO2021112918A1 (en) 2019-12-02 2021-06-10 Caris Mpi, Inc. Pan-cancer platinum response predictor
US20210172012A1 (en) 2019-12-04 2021-06-10 Illumina, Inc. Preparation of dna sequencing libraries for detection of dna pathogens in plasma
WO2021113644A1 (en) 2019-12-05 2021-06-10 Multivir Inc. Combinations comprising a cd8+ t cell enhancer, an immune checkpoint inhibitor and radiotherapy for targeted and abscopal effects for the treatment of cancer
US20230050863A1 (en) 2019-12-09 2023-02-16 Roche Molecular Systems, Inc. Dicationic fluorescent dyes
AU2020400056A1 (en) 2019-12-12 2022-07-07 President And Fellows Of Harvard College Compositions and methods for light-directed biomolecular barcoding
WO2021118927A1 (en) 2019-12-13 2021-06-17 Insideoutbio, Inc. Methods and compositions for targeted delivery of nucleic acid therapeutics
JP2023506181A (ja) 2019-12-13 2023-02-15 アルナイラム ファーマシューティカルズ， インコーポレイテッド ヒト第９染色体オープンリーディングフレーム７２（Ｃ９ＯＲＦ７２）ｉＲＮＡ剤組成物およびその使用方法
JP2023509845A (ja) 2019-12-13 2023-03-10 インスピルナ，インコーポレーテッド 金属塩及びその使用
WO2021126734A1 (en) 2019-12-16 2021-06-24 Alnylam Pharmaceuticals, Inc. Patatin-like phospholipase domain containing 3 (pnpla3) irna compositions and methods of use thereof
US11702474B2 (en) 2019-12-17 2023-07-18 Pfizer Inc. Antibodies specific for CD47, PD-L1, and uses thereof
US20210188971A1 (en) 2019-12-19 2021-06-24 Quidel Corporation Monoclonal antibody fusions
GB201919029D0 (en) 2019-12-20 2020-02-05 Cartana Ab Method of detecting an analyte
EP4077395A1 (en) 2019-12-20 2022-10-26 Poseida Therapeutics, Inc. Anti-muc1 compositions and methods of use
WO2021123387A1 (en) 2019-12-20 2021-06-24 Da Volterra Prediction of clinical manifestations of gut microbiota dysbiosis
EP4077731A1 (en) 2019-12-22 2022-10-26 Yeda Research and Development Co. Ltd Diagnosis of frontotemporal dementia
US11060141B1 (en) 2019-12-23 2021-07-13 Stilla Technologies Multiplex drop-off digital polymerase chain reaction methods
CN114885610A (zh) 2019-12-23 2022-08-09 10X基因组学有限公司 使用rna模板化连接进行空间分析的方法
WO2021133916A1 (en) 2019-12-23 2021-07-01 Abbott Laboratories Compositions and methods for detecting picobirnavirus
WO2021138325A1 (en) 2019-12-30 2021-07-08 Abbott Laboratories Compositions and methods for detecting bunyavirus
IL271778A (en) 2019-12-31 2021-06-30 Ichilov Tech Ltd Methods for treating atopic dermatitis
WO2021137231A1 (en) 2019-12-31 2021-07-08 Kahr Medical Ltd. Methods of culturing t cells with a 4-1bbl fusion polypeptide and uses of same
US20230048361A1 (en) 2019-12-31 2023-02-16 Kahr Medical Ltd. Methods of culturing t cells and uses of same
US20220356537A1 (en) 2019-12-31 2022-11-10 Roche Molecular Systems, Inc. Quantitative pcr screening of inducible prophage from bacterial isolates
CN115209909A (zh) 2020-01-02 2022-10-18 伊迪生物治疗公司 递送组合物和方法
WO2021140123A1 (en) 2020-01-06 2021-07-15 Evaxion Biotech Aps Vaccines targeting neisseria gonorrhoeae
IL272074A (en) 2020-01-15 2021-07-29 Immunity Pharma Ltd Peptide compounds and their use in methods of treating diseases
US20230227896A1 (en) 2020-01-16 2023-07-20 Dnae Diagnostics Limited Compositions, Kits and Methods for Isolating Target Polynucleotides
US11702693B2 (en) 2020-01-21 2023-07-18 10X Genomics, Inc. Methods for printing cells and generating arrays of barcoded cells
US11732299B2 (en) 2020-01-21 2023-08-22 10X Genomics, Inc. Spatial assays with perturbed cells
WO2021151114A1 (en) 2020-01-22 2021-07-29 Life Technologies Corporation Immune repertoire biomarkers in autoimmune disease and immunodeficiency disorders
WO2021148983A1 (en) 2020-01-24 2021-07-29 Pfizer Inc. Anti-e-selectin antibodies, compositions and methods of use
WO2021152584A1 (en) 2020-01-28 2021-08-05 Ariel Scientific Innovations Ltd. Methods of analyzing cell membranes
EP4096647A1 (en) 2020-01-30 2022-12-07 Yeda Research and Development Co. Ltd Treating acute liver disease with tlr-mik inhibitors
IL272389A (en) 2020-01-30 2021-08-31 Yeda Res & Dev Kits containing antibodies to PD-L1 and their uses in therapy
IL272390A (en) 2020-01-30 2021-08-31 Yeda Res & Dev Cancer treatment methods
WO2021152586A1 (en) 2020-01-30 2021-08-05 Yeda Research And Development Co. Ltd. Methods of analyzing microbiome, immunoglobulin profile and physiological state
WO2021154941A1 (en) 2020-01-31 2021-08-05 Alnylam Pharmaceuticals, Inc. Complement component c5 irna compositions for use in the treatment of amyotrophic lateral sclerosis (als)
EP3859012A1 (en) 2020-02-03 2021-08-04 Albert-Ludwigs-Universität Freiburg Methods for amplification of genomic dna and preparation of sequencing libraries
US11898205B2 (en) 2020-02-03 2024-02-13 10X Genomics, Inc. Increasing capture efficiency of spatial assays
US11732300B2 (en) 2020-02-05 2023-08-22 10X Genomics, Inc. Increasing efficiency of spatial analysis in a biological sample
IL295500A (en) 2020-02-09 2022-10-01 Nlc Pharma Ltd Rapid detection test for sars-cov-2
IL272586A (en) 2020-02-10 2021-08-31 Yeda Res & Dev A method for cell cluster analysis
US11835462B2 (en) 2020-02-11 2023-12-05 10X Genomics, Inc. Methods and compositions for partitioning a biological sample
TW202140012A (zh) 2020-02-12 2021-11-01 比利時商健生藥品公司 用於治療尿路上皮癌的ｆｇｆｒ酪胺酸激酶抑制劑和抗ｐｄ１藥劑
WO2021160764A1 (en) 2020-02-12 2021-08-19 Janssen Pharmaceutica Nv Fgfr tyrosine kinase inhibitors for the treatment of high-risk non-muscle invasive bladder cancer
EP4107284A1 (en) 2020-02-17 2022-12-28 10X Genomics, Inc. In situ analysis of chromatin interaction
US11891654B2 (en) 2020-02-24 2024-02-06 10X Genomics, Inc. Methods of making gene expression libraries
EP4110928A1 (en) 2020-02-28 2023-01-04 Cambridge Enterprise Limited Methods, plants and compositions for overcoming nutrient suppression of mycorrhizal symbiosis
MX2022010521A (es) 2020-02-28 2022-09-19 Takeda Pharmaceuticals Co Metodo para producir linfocitos citoliticos naturales a partir de celulas madre pluripotentes.
EP4114421A1 (en) 2020-03-02 2023-01-11 Tenaya Therapeutics, Inc. Gene vector control by cardiomyocyte-expressed micrornas
CA3169529A1 (en) 2020-03-04 2021-09-10 Jingjing Jiang Compositions and methods for the treatment of metabolic liver disorders
US11768175B1 (en) 2020-03-04 2023-09-26 10X Genomics, Inc. Electrophoretic methods for spatial analysis
EP4114985A1 (en) 2020-03-04 2023-01-11 Gen-Probe Incorporated Compositions and methods for detecting sars-cov-2 nucleic acid
EP4114947A1 (en) 2020-03-05 2023-01-11 Alnylam Pharmaceuticals, Inc. Complement component c3 irna compositions and methods of use thereof for treating or preventing complement component c3-associated diseases
EP3990667B1 (en) 2020-03-05 2024-01-31 Institut Pasteur Methods for the specific and sensitive detection of sars-cov-2
EP4114948A1 (en) 2020-03-06 2023-01-11 Alnylam Pharmaceuticals, Inc. Ketohexokinase (khk) irna compositions and methods of use thereof
JP2023517044A (ja) 2020-03-09 2023-04-21 ファイザー・インク 融合タンパク質およびその使用
WO2021181388A1 (en) 2020-03-09 2021-09-16 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Methods of diagnosing and treating p53 mutant cancer
US20210332448A1 (en) 2020-03-09 2021-10-28 Janssen Pharmaceutica Nv Compositions and methods for quantifying integration of recombinant vector nucleic acid
EP4118107A1 (en) 2020-03-11 2023-01-18 Poseida Therapeutics, Inc. Chimeric stimulatory receptors and methods of use in t cell activation and differentiation
WO2021186431A1 (en) 2020-03-16 2021-09-23 Yeda Research And Development Co. Ltd. Peptide analogs and use of same in treating diseases, disorders or conditions associated with a mutant p53 protein
IL296662A (en) 2020-03-24 2022-11-01 Generation Bio Co Non-viral DNA vectors and their use for expression of Gauche cure
JP2023520359A (ja) 2020-03-25 2023-05-17 エラスムス・ユニヴァーシティ・メディカル・センター・ロッテルダム 放射性核種イメージングのためのレポーター系
AU2021245409A1 (en) 2020-03-29 2022-11-24 Yeda Research And Development Co. Ltd. Variants of beta-glucocerebrosidase for use in treating Gaucher Disease
EP4130747A1 (en) 2020-03-30 2023-02-08 Rophelbio Co., Ltd.a Biomarker for cancer immunotherapy and use thereof
CN115484836A (zh) 2020-03-31 2022-12-16 百欧穆斯有限公司 用于预防和治疗烟雾诱发的肺部损伤的细菌
CA3178308A1 (en) 2020-03-31 2021-10-07 Sana Biotechnology, Inc. Targeted lipid particles and compositions and uses thereof
US11149320B1 (en) 2020-03-31 2021-10-19 Diasorin S.P.A. Assays for the detection of SARS-CoV-2
IT202000007357A1 (it) 2020-04-07 2021-10-07 Elitechgroup S P A Metodo per il rilevamento e la quantificazione di citomegalovirus umano attraverso RNA virionici.
EP4133077A1 (en) 2020-04-07 2023-02-15 Alnylam Pharmaceuticals, Inc. Transmembrane serine protease 2 (tmprss2) irna compositions and methods of use thereof
WO2021205453A1 (en) 2020-04-07 2021-10-14 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Methods for nucleic acid detection
WO2021205459A1 (en) 2020-04-07 2021-10-14 Ramot At Tel-Aviv University Ltd. Cannabidiol-containing compositions and uses thereof
EP4133076A1 (en) 2020-04-07 2023-02-15 Alnylam Pharmaceuticals, Inc. Angiotensin-converting enzyme 2 (ace2) irna compositions and methods of use thereof
WO2021205325A1 (en) 2020-04-08 2021-10-14 Pfizer Inc. Anti-gucy2c antibodies and uses thereof
WO2021205013A1 (en) 2020-04-09 2021-10-14 Sitokine Limited Compositions and methods for treating covid-19
WO2021209993A1 (en) 2020-04-13 2021-10-21 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Use of metabolic regulators for the treatment of covid-19
EP4135746A1 (en) 2020-04-13 2023-02-22 Exoprother Medical Ltd. Cell-derived vesicles comprising wild-type p53 protein for antiviral therapy
CN115996747A (zh) 2020-04-14 2023-04-21 波赛达治疗公司 用于治疗癌症的组合物和方法
CN116075725A (zh) 2020-04-17 2023-05-05 瑞泽恩制药公司 用于冠状病毒中和抗体的检测测定法
WO2021212101A1 (en) 2020-04-17 2021-10-21 Vyriad, Inc. Compositions for treating and/or preventing coronavirus infections
WO2021216708A1 (en) 2020-04-22 2021-10-28 10X Genomics, Inc. Methods for spatial analysis using targeted rna depletion
CN116368221A (zh) 2020-04-22 2023-06-30 因达普塔治疗公司 自然杀伤(nk)细胞组合物及其生成方法
US11702689B2 (en) 2020-04-24 2023-07-18 Microsoft Technology Licensing, Llc Homopolymer primers for amplification of polynucleotides created by enzymatic synthesis
CN115955972A (zh) 2020-04-27 2023-04-11 阿尔尼拉姆医药品有限公司 载脂蛋白E(APOE)iRNA剂组合物及其使用方法
AU2021265813A1 (en) 2020-04-30 2022-11-10 Alnylam Pharmaceuticals, Inc. Complement factor B (CFB) iRNA compositions and methods of use thereof
CN115997030A (zh) 2020-04-30 2023-04-21 德迈逊科技有限公司 用于大分子操作的装置和方法
US11739359B2 (en) 2020-05-01 2023-08-29 Microsoft Technology Licensing, Llc Universal template strands for enzymatic polynucleotide synthesis
WO2022113069A1 (en) 2020-11-24 2022-06-02 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. E protein channel blockers and orf3 inhibitors as anti-covid-19 agents
WO2021224873A1 (en) 2020-05-07 2021-11-11 Grifols Diagnostic Solutions Inc. Methods and compositions for detecting sars-cov-2 nucleic acid
EP3907301A1 (en) 2020-05-08 2021-11-10 Istituto Europeo di Oncologia S.r.l. Methods and kits for determining the risk of breast cancer recurrence
EP3909601A1 (en) 2020-05-11 2021-11-17 LeukoCom GmbH A novel antibody binding specifically to human ceacam1/3/5 and use thereof
WO2021229577A1 (en) 2020-05-12 2021-11-18 Collplant Ltd. Collagen as a delivery tool for metal-based anti-viral agents
EP4150077A1 (en) 2020-05-15 2023-03-22 Korro Bio, Inc. Methods and compositions for the adar-mediated editing of transmembrane channel-like protein 1 (tmc1)
EP4150078A1 (en) 2020-05-15 2023-03-22 Korro Bio, Inc. Methods and compositions for the adar-mediated editing of argininosuccinate lyase (asl)
EP4150086A1 (en) 2020-05-15 2023-03-22 Korro Bio, Inc. Methods and compositions for the adar-mediated editing of leucine rich repeat kinase 2 (lrrk2)
WO2021231680A1 (en) 2020-05-15 2021-11-18 Korro Bio, Inc. Methods and compositions for the adar-mediated editing of methyl-cpg binding protein 2 (mecp2)
WO2021231692A1 (en) 2020-05-15 2021-11-18 Korro Bio, Inc. Methods and compositions for the adar-mediated editing of otoferlin (otof)
CA3162416C (en) 2020-05-15 2023-07-04 Korro Bio, Inc. Methods and compositions for the adar-mediated editing of argininosuccinate synthetase (ass1)
WO2021231691A1 (en) 2020-05-15 2021-11-18 Korro Bio, Inc. Methods and compositions for the adar-mediated editing of retinoschisin 1 (rsi)
JP2023526529A (ja) 2020-05-19 2023-06-21 アンスティテュ・クリー サイトカイン放出症候群の診断及び処置の方法
WO2021233904A1 (en) 2020-05-19 2021-11-25 Aarhus Universitet Lysm receptor motifs
US10941453B1 (en) 2020-05-20 2021-03-09 Paragon Genomics, Inc. High throughput detection of pathogen RNA in clinical specimens
WO2021236852A1 (en) 2020-05-20 2021-11-25 Sana Biotechnology, Inc. Methods and compositions for treatment of viral infections
IL274811B (en) 2020-05-20 2021-05-31 Yeda Res & Dev Spatial information is developed for the analysis of individual cells
EP4153775A1 (en) 2020-05-22 2023-03-29 10X Genomics, Inc. Simultaneous spatio-temporal measurement of gene expression and cellular activity
WO2021237087A1 (en) 2020-05-22 2021-11-25 10X Genomics, Inc. Spatial analysis to detect sequence variants
WO2021242834A1 (en) 2020-05-26 2021-12-02 10X Genomics, Inc. Method for resetting an array
WO2021243256A1 (en) 2020-05-29 2021-12-02 FUJIFILM Cellular Dynamics, Inc. Retinal pigmented epithelium and photoreceptor dual cell aggregates and methods of use thereof
MX2022015002A (es) 2020-05-29 2023-03-03 Fujifilm Cellular Dynamics Inc Bicapa del epitelio pigmentario de la retina y fotorreceptores y uso de los mismos.
JP2023528608A (ja) 2020-06-01 2023-07-05 アムジエン・インコーポレーテツド ＨＳＤ１７Ｂ１３発現を阻害するためのＲＮＡｉコンストラクト及びその使用方法
CN116249785A (zh) 2020-06-02 2023-06-09 10X基因组学有限公司 用于抗原-受体的空间转录组学
EP4025692A2 (en) 2020-06-02 2022-07-13 10X Genomics, Inc. Nucleic acid library methods
AR122534A1 (es) 2020-06-03 2022-09-21 Triplet Therapeutics Inc Métodos para el tratamiento de los trastornos de expansión por repetición de nucleótidos asociados con la actividad de msh3
EP4163397A1 (en) 2020-06-05 2023-04-12 Seegene, Inc. Specimen transport kit for detecting respiratory pathogens and methods for detecting respiratory pathogens using same
EP4162074B1 (en) 2020-06-08 2024-04-24 10X Genomics, Inc. Methods of determining a surgical margin and methods of use thereof
EP4162050A1 (en) 2020-06-09 2023-04-12 Alnylam Pharmaceuticals, Inc. Rnai compositions and methods of use thereof for delivery by inhalation
EP4165207A1 (en) 2020-06-10 2023-04-19 10X Genomics, Inc. Methods for determining a location of an analyte in a biological sample
WO2021252574A1 (en) 2020-06-10 2021-12-16 Sera Prognostics, Inc. Nucleic acid biomarkers for placental dysfunction
CA3184289A1 (en) 2020-06-18 2021-12-23 Alnylam Pharmaceuticals, Inc. Xanthine dehydrogenase (xdh) irna compositions and methods of use thereof
WO2021260675A1 (en) 2020-06-24 2021-12-30 Yeda Research And Development Co. Ltd. Agents for sensitizing solid tumors to treatment
WO2021263111A1 (en) 2020-06-25 2021-12-30 10X Genomics, Inc. Spatial analysis of dna methylation
CN115989415A (zh) 2020-06-30 2023-04-18 健肺生命人工智能公司 用于检测肺癌的方法
US20230287383A1 (en) 2020-07-03 2023-09-14 Engenes Biotech Gmbh PYRROLYSYL-tRNA SYNTHETASE VARIANTS AND USES THEREOF
WO2022008641A1 (en) 2020-07-08 2022-01-13 Roche Sequencing Solutions, Inc. Split-pool synthesis apparatus and methods of performing split-pool synthesis
CN111534576B (zh) 2020-07-08 2020-10-02 圣湘生物科技股份有限公司 用于荧光定量pcr的方法、组合物、试剂盒及其用途
EP4179113A1 (en) 2020-07-08 2023-05-17 F. Hoffmann-La Roche AG Targeted depletion of non-target library molecules using poison primers during target capture of next-generation sequencing libraries
JP2023540429A (ja) 2020-07-10 2023-09-25 アンセルム（アンスティチュート・ナシオナル・ドゥ・ラ・サンテ・エ・ドゥ・ラ・ルシェルシュ・メディカル） てんかんを治療するための方法及び組成物
WO2022013874A1 (en) 2020-07-14 2022-01-20 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Composition comprising cannabinoids, terpenes, and flavonoids for treating depression
AU2021204717A1 (en) 2020-07-15 2022-02-03 Seminis Vegetable Seeds, Inc. Green Bean Plants with Improved Disease Resistance
EP4182346A1 (en) 2020-07-17 2023-05-24 Pfizer Inc. Therapeutic antibodies and their uses
AU2021308095A1 (en) 2020-07-17 2023-03-09 Gen-Probe Incorporated Detection of macrolide-resistant mycoplasma genitalium
EP4185610A2 (en) 2020-07-21 2023-05-31 Allogene Therapeutics, Inc. Chimeric antigen receptors with enhanced signaling and activities and uses thereof
KR20230056683A (ko) 2020-07-23 2023-04-27 라이프 테크놀로지스 코포레이션 생물학적 분석에 사용하기 위한 에너지 전달 염료 접합체
CA3186950A1 (en) 2020-07-23 2022-01-27 Scott Benson Compositions, systems and methods for biological analysis involving energy transfer dye conjugates and analytes comprising the same
JP2023535604A (ja) 2020-07-30 2023-08-18 ファイザー・インク 遺伝子複製を有する細胞およびその使用
US20230303711A1 (en) 2020-07-31 2023-09-28 Bio-Thera Solutions, Ltd. Anti-cd47 antibody and use thereof
IL276599A (en) 2020-08-09 2022-03-01 Yeda Res & Dev T cell receptor unique to mage-a1 and its uses
IL276627A (en) 2020-08-10 2022-03-01 Yeda Res & Dev Compositions for diagnosis and treatment of coronavirus infections
EP4196606A1 (en) 2020-08-12 2023-06-21 Phylos Bioscience, Inc. Varin markers
US20230309480A1 (en) 2020-08-18 2023-10-05 International Rice Research Institute Methods of increasing outcrossing rates in gramineae
CA3188230A1 (en) 2020-08-19 2022-02-24 John B. Kisiel Detecting non-hodgkin lymphoma
CN116194088A (zh) 2020-08-27 2023-05-30 大冢制药株式会社 使用mdm2拮抗剂治疗癌症的生物标志物
EP4204447A1 (en) 2020-08-28 2023-07-05 Sana Biotechnology, Inc. Modified anti-viral binding agents
WO2022047359A1 (en) 2020-08-31 2022-03-03 Berg Llc Protein biomarkers for pancreatic cancer
CN116348616A (zh) 2020-09-04 2023-06-27 心脏诊断公司 用于预测和/或监测心血管疾病及其治疗的方法和组合物
EP4210702A1 (en) 2020-09-14 2023-07-19 JANSSEN Pharmaceutica NV Fgfr inhibitor combination therapies
IL277488A (en) 2020-09-21 2022-04-01 Yeda Res & Dev Weight regulation method
EP3971303A1 (en) 2020-09-21 2022-03-23 ETH Zurich A metallic sample holder, a probe for performing detection reactions, and apparatus for receiving the sample holder
US11926822B1 (en) 2020-09-23 2024-03-12 10X Genomics, Inc. Three-dimensional spatial analysis
IL301503A (en) 2020-09-23 2023-05-01 Yeda res & development co ltd Methods and preparations for the treatment of the disease caused by the corona virus
IL277743A (en) 2020-10-01 2022-04-01 Yeda Res & Dev A method for diagnosing breast cancer
KR20230113283A (ko) 2020-10-05 2023-07-28 프로탈릭스 리미티드 다이서-유사 넉아웃 식물 세포
GB202015772D0 (en) 2020-10-05 2020-11-18 Univ Newcastle Pngase enzymes
WO2022076291A1 (en) 2020-10-05 2022-04-14 Alnylam Pharmaceuticals, Inc. G protein-coupled receptor 75 (gpr75) irna compositions and methods of use thereof
JP2023545740A (ja) 2020-10-07 2023-10-31 プロタリクス リミテッド 長期活性ＤＮａｓｅ
US11781156B2 (en) 2020-10-09 2023-10-10 Tenaya Therapeutics, Inc. Plakophillin-2 gene therapy methods and compositions
BR112023005980A2 (pt) 2020-10-09 2023-05-02 Childrens Medical Center Anticorpos cd1a e seus usos
WO2022079719A1 (en) 2020-10-15 2022-04-21 Yeda Research And Development Co. Ltd. Method of treating myeloid malignancies
US11730133B2 (en) 2020-10-21 2023-08-22 Equi-Nom Ltd High yield sesame
CA3177256A1 (en) 2020-10-21 2022-04-28 Gen-Probe Incorporated Fluid container management system
IL278401A (en) 2020-10-29 2022-05-01 Yeda Res & Dev Polynucleotides for editing RNA and a method for using them
IL278473A (en) 2020-11-03 2022-06-01 Yeda Res & Dev Methods for diagnosing and determining treatment in multiple myeloma
CA3193888A1 (en) 2020-11-05 2022-05-12 Qiufeng ZHANG Rapid identification and typing of vibrio parahaemolyticus
WO2022097157A2 (en) 2020-11-09 2022-05-12 1E Therapeutics, Ltd. Catalytic sequence based methods of treating or preventing bacterial infections
EP4244355A1 (en) 2020-11-13 2023-09-20 Alnylam Pharmaceuticals, Inc. Coagulation factor v (f5) irna compositions and methods of use thereof
WO2022104391A1 (en) 2020-11-16 2022-05-19 Life Technologies Corporation Compositions and methods for immune repertoire monitoring
EP4247976A1 (en) 2020-11-17 2023-09-27 Life Technologies Corporation Compositions and methods for immune repertoire monitoring
AU2021386293A1 (en) 2020-11-25 2023-06-01 Dupont Nutrition Biosciences Aps Bacterium with reduced sensitivity to bacteriophage
CA3200350A1 (en) 2020-11-26 2022-06-02 Yanay OFRAN Modified high molecular weight glutenin subunit and uses thereof
WO2022120019A2 (en) 2020-12-02 2022-06-09 Massachusetts Institute Of Technology A tunable phosphorylation-based feedback controller of mammalian gene expression
WO2022117784A1 (en) 2020-12-04 2022-06-09 F. Hoffmann-La Roche Ag Compositions and methods for detection of malaria
WO2022125490A1 (en) 2020-12-08 2022-06-16 Alnylam Pharmaceuticals, Inc. Coagulation factor x (f10) irna compositions and methods of use thereof
EP4012046A1 (en) 2020-12-11 2022-06-15 10X Genomics, Inc. Methods and compositions for multimodal in situ analysis
IL279559A (en) 2020-12-17 2022-07-01 Yeda Res & Dev Controlling the ubiquitination process of mlkl for disease treatment
KR20230122618A (ko) 2020-12-21 2023-08-22 알로젠 테라퓨틱스 인코포레이티드 프로테아제 활성화 cd45-게이트 car
WO2022140028A1 (en) 2020-12-21 2022-06-30 10X Genomics, Inc. Methods, compositions, and systems for capturing probes and/or barcodes
WO2022136477A1 (en) 2020-12-22 2022-06-30 F. Hoffmann-La Roche Ag Methods for performing multiplexed real-time pcr with the use of large stokes shift fluorescent dyes
EP4267760A1 (en) 2020-12-23 2023-11-01 10X Genomics, Inc. Methods and compositions for analyte detection
JP2024501832A (ja) 2020-12-24 2024-01-16 インテグレイテツド・デイー・エヌ・エイ・テクノロジーズ・インコーポレイテツド 高忠実度ＤＮＡポリメラーゼによるｒｈＰＣＲベース増幅産物シーケンシングにおいて、プライマー二量体及びオフターゲット増幅を低減するＲＮアーゼＨ２突然変異体
WO2022140793A1 (en) 2020-12-24 2022-06-30 Life Technologies Corporation Compositions and methods for highly sensitive detection of target sequences in multiplex reactions
KR20230133859A (ko) 2020-12-28 2023-09-19 1이 테라퓨틱스 엘티디. p21 mRNA 표적화 DNA자임
EP4267741A2 (en) 2020-12-28 2023-11-01 1E Therapeutics, Ltd. P21 mrna target areas for silencing
WO2022144903A1 (en) 2021-01-03 2022-07-07 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Cancer driver mutation diagnostics
EP4274896A1 (en) 2021-01-05 2023-11-15 Alnylam Pharmaceuticals, Inc. Complement component 9 (c9) irna compositions and methods of use thereof
AU2022206415A1 (en) 2021-01-10 2023-08-17 Supermeat The Essence Of Meat Ltd. Pluripotent stem cell aggregates and microtissues obtained therefrom for the cultured meat industry
WO2022153286A1 (en) 2021-01-14 2022-07-21 Yeda Research And Development Co. Ltd. Methods of producing vitamin d
US20240110160A1 (en) 2021-01-15 2024-04-04 Board Of Regents, The University Of Texas System A trans-complementation system for sars-cov-2
BR112023014676A2 (pt) 2021-01-21 2023-10-03 Technion Res & Devel­Opment Foundation Limited Nanopartículas de rnai e métodos de uso das mesmas na agricultura
IL280340B (en) 2021-01-21 2022-04-01 Yeda Res & Dev Antibodies, peptides and their combinations for the treatment and prevention of corona virus infections
EP4281589A1 (en) 2021-01-25 2023-11-29 Life Technologies Corporation Compositions, kits and methods for detection of viral variant sequences
EP4284945A1 (en) 2021-01-26 2023-12-06 10X Genomics, Inc. Nucleic acid analog probes for in situ analysis
IL303853A (en) 2021-01-29 2023-08-01 Allogene Therapeutics Inc Knockdown or knockout of one or more TAP2, NLRC5, B2m, TRAC, RFX5, RFXAP, and RFXANK to reduce T cell recognition of allogeneic cell products
CA3202849A1 (en) 2021-02-09 2022-08-18 University Of Houston System Oncolytic virus for systemic delivery and enhanced anti-tumor activities
WO2022171685A1 (en) 2021-02-10 2022-08-18 INSERM (Institut National de la Santé et de la Recherche Médicale) Tnf-alpha blocking agent for preventing, suppressing and/or delaying the onset of type 1 diabetes
KR20230146048A (ko) 2021-02-12 2023-10-18 알닐람 파마슈티칼스 인코포레이티드 슈퍼옥사이드 디스뮤타제 1(sod1) irna 조성물 및 슈퍼옥사이드 디스뮤타제 1- (sod1-) 관련 신경퇴행성 질환을 치료하거나 예방하기 위한 이의 사용 방법
JP2024506954A (ja) 2021-02-18 2024-02-15 イェダ リサーチ アンド デベロップメント カンパニー リミテッド ワクチン作製用の遺伝子改変細菌
IL305315A (en) 2021-02-18 2023-10-01 Yeda res & development co ltd Methods for producing vaccines
WO2022178078A1 (en) 2021-02-19 2022-08-25 Theripion, Inc. Paraoxonase fusion polypeptides and related compositions and methods
WO2022182792A1 (en) 2021-02-23 2022-09-01 Poseida Therapeutics, Inc. Compositions and methods for delivery of nucleic acids
EP4298220A1 (en) 2021-02-25 2024-01-03 Alnylam Pharmaceuticals, Inc. Prion protein (prnp) irna compositions and methods of use thereof
IL305153A (en) 2021-02-26 2023-10-01 Alnylam Pharmaceuticals Inc Ketohexokinase (KHK) iRNA compositions and methods of using them
KR20230165212A (ko) 2021-03-02 2023-12-05 다나-파버 캔서 인스티튜트 인크. 적혈구 장애의 치료 방법
GB202103080D0 (en) 2021-03-04 2021-04-21 Otsuka Pharma Co Ltd Cancer biomarkers
WO2022187671A1 (en) 2021-03-04 2022-09-09 Poseida Therapeutics, Inc. Compositions and methods for the treatment of hemophilia
KR20230151518A (ko) 2021-03-04 2023-11-01 알로젠 테라퓨틱스 인코포레이티드 치료 세포를 동종이계 거부반응 및 활성화 유도된 세포 사멸로부터 보호하기 위한 FasL 발현 및 FasR 유전자 녹아웃
IL305418A (en) 2021-03-04 2023-10-01 Alnylam Pharmaceuticals Inc Angiopoietin-like 3 (ANGPTL3) IRNA compositions and methods of using them
EP4305062A1 (en) 2021-03-12 2024-01-17 Janssen Biotech, Inc. Method of treating psoriatic arthritis patients with inadequate response to tnf therapy with anti-il23 specific antibody
WO2022192519A1 (en) 2021-03-12 2022-09-15 Alnylam Pharmaceuticals, Inc. Glycogen synthase kinase 3 alpha (gsk3a) irna compositions and methods of use thereof
IL305802A (en) 2021-03-12 2023-11-01 Janssen Biotech Inc A safe and effective method for the treatment of rheumatoid arthritis with a specific anti-IL23 antibody
US20220290221A1 (en) 2021-03-15 2022-09-15 Roche Molecular Systems, Inc. Compositions and methods for detecting severe acute respiratory syndrome coronavirus 2 (sars-cov-2) variants having spike protein mutations
CA3211659A1 (en) 2021-03-15 2022-09-22 Gen-Probe Incorporated Compositions and methods for biological sample processing
IL281561A (en) 2021-03-16 2022-10-01 Yeda Res & Dev Methods and devices for growing mouse embryos outside the uterus
WO2022198068A1 (en) 2021-03-18 2022-09-22 10X Genomics, Inc. Multiplex capture of gene and protein expression from a biological sample
WO2022195504A1 (en) 2021-03-19 2022-09-22 Pfizer Inc. Method of treating osteoarthritis pain with an anti ngf antibody
EP4314350A1 (en) 2021-03-23 2024-02-07 Life Technologies Corporation Compositions, kits, and methods for variant-resistant detection of target viral sequences
EP4314330A1 (en) 2021-03-26 2024-02-07 F. Hoffmann-La Roche AG Hybridization buffer formulations
IL307239A (en) 2021-03-29 2023-11-01 Alnylam Pharmaceuticals Inc Preparations containing Huntingtin IRNA factor (HTT) and methods of using them
EP4313091A1 (en) 2021-03-30 2024-02-07 Biomx Ltd. Pseudomonas bacteriophage and uses thereof
WO2022212153A1 (en) 2021-04-01 2022-10-06 Alnylam Pharmaceuticals, Inc. Proline dehydrogenase 2 (prodh2) irna compositions and methods of use thereof
WO2022216846A1 (en) 2021-04-06 2022-10-13 Berg Llc Protein markers for estrogen receptor (er)-positive-like and estrogen receptor (er)-negative-like breast cancer
IL307528A (en) 2021-04-06 2023-12-01 Bpgbio Inc Protein markers for the prognosis of breast cancer progression
IL282188A (en) 2021-04-08 2022-11-01 Yeda Res & Dev Combined use of ketamine and bretigabine for the treatment of psychiatric disorders
AU2022255565A1 (en) 2021-04-08 2023-11-09 Joslin Diabetes Center, Inc. Methods of diagnosing and predicting renal decline
KR20240004540A (ko) 2021-04-20 2024-01-11 비온드 바이오로직스 엘티디 세포내 전달 조성물
AU2022262606A1 (en) 2021-04-21 2023-11-09 Indapta Therapeutics, Inc. Methods of treatment and dosing of natural killer cell compositions
BR112023022284A2 (pt) 2021-04-26 2023-12-26 Alnylam Pharmaceuticals Inc Composições de irna de protease transmembrana, serina 6 (tmprss6) e métodos de uso da mesma
KR20240011714A (ko) 2021-04-27 2024-01-26 제너레이션 바이오 컴퍼니 치료용 항체를 발현하는 비바이러스성 dna 벡터 및 이의 용도
WO2022229846A1 (en) 2021-04-29 2022-11-03 Pfizer Inc. Treatment of cancer using a transforming growth factor beta receptor type 1 inhibitor
EP4330396A1 (en) 2021-04-29 2024-03-06 Alnylam Pharmaceuticals, Inc. Signal transducer and activator of transcription factor 6 (stat6) irna compositions and methods of use thereof
WO2022235929A1 (en) 2021-05-05 2022-11-10 Radius Pharmaceuticals, Inc. Animal model having homologous recombination of mouse pth1 receptor
EP4334354A1 (en) 2021-05-06 2024-03-13 Dana-Farber Cancer Institute, Inc. Antibodies against alk and methods of use thereof
WO2022233930A1 (en) 2021-05-06 2022-11-10 F. Hoffmann-La Roche Ag Compositions and methods for detecting hepatitis delta virus by a dual-target assay
BR112023022181A2 (pt) 2021-05-07 2024-02-06 Astellas Inst For Regenerative Medicine Métodos de geração de hepatócitos maduros
AU2022272135A1 (en) 2021-05-12 2024-01-04 Biomx Ltd. Staphylococcus bacteriophage and uses thereof
AU2022273052A1 (en) 2021-05-14 2023-11-30 Gen-Probe Incorporated Compositions and methods for detecting human adenovirus nucleic acid
BR112023023935A2 (pt) 2021-05-19 2024-01-30 Janssen Pharmaceutica Nv Inibidores de tirosina quinase de fgfr para o tratamento de tumores sólidos avançados
EP4348265A2 (en) 2021-05-25 2024-04-10 Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. Diagnosis of autism spectrum disorder by multiomics platform
CN117881777A (zh) 2021-05-26 2024-04-12 富士胶片细胞动力公司 防止多能干细胞中基因快速沉默的方法
WO2022251428A2 (en) 2021-05-26 2022-12-01 The Board Of Trustees Of The University Of Illinois C4 plants with increased photosynthetic efficiency
IL283563A (en) 2021-05-30 2022-12-01 Yeda Res & Dev Profiling of amps for the diagnosis, monitoring and treatment of microbiome-related diseases
TW202317762A (zh) 2021-06-02 2023-05-01 美商艾拉倫製藥股份有限公司 含有類ＰＡＴＡＴＩＮ磷脂酶結構域３（ＰＮＰＬＡ３）的ｉＲＮＡ組成物及其使用方法
IL309032A (en) 2021-06-03 2024-02-01 Mazen Animal Health Inc Oral administration of coronavirus spike protein to alter cytokine levels and provide passive immunity to newborn pigs
TW202308663A (zh) 2021-06-04 2023-03-01 美商艾拉倫製藥股份有限公司 人類染色體９開讀框７２（Ｃ９ＯＲＦ７２）ｉＲＮＡ劑組成物及其使用方法
IL309061A (en) 2021-06-06 2024-02-01 Yeda res & development co ltd Combined cancer treatment
EP4353810A1 (en) 2021-06-07 2024-04-17 Hitachi High-Tech Corporation Dna detection method and dna detection system
AR126070A1 (es) 2021-06-08 2023-09-06 Alnylam Pharmaceuticals Inc Composiciones y métodos para tratar o prevenir la enfermedad de stargardt y/o trastornos asociados con la proteína transportadora de retinol 4 (rbp4)
WO2022261183A2 (en) 2021-06-08 2022-12-15 Dana-Farber Cancer Institute, Inc. Compositions and methods for treating and/or identifying an agent for treating intestinal cancers
WO2022265965A1 (en) 2021-06-14 2022-12-22 10X Genomics, Inc. Reverse transcriptase variants for improved performance
CN117642380A (zh) 2021-06-14 2024-03-01 世代生物公司 阳离子脂质及其组合物
IL308468A (en) 2021-06-15 2024-01-01 Allogene Therapeutics Inc Selective Targeting of Host CD70+ ALLOREACTIVE Cells to Extend Allogeneic CAR T Cell Persistence
AR126145A1 (es) 2021-06-15 2023-09-13 Takeda Pharmaceuticals Co Método para producir linfocitos citolíticos naturales a partir de células madre pluripotentes
NL2028466B1 (en) 2021-06-16 2022-12-21 Sakata Holland B V Methods of sorting matthiola seeds
WO2022264076A1 (en) 2021-06-16 2022-12-22 Seedx Technologies Inc. Methods of sorting matthiola seeds
WO2022269023A1 (en) 2021-06-25 2022-12-29 F. Hoffmann-La Roche Ag Methods for performing temperature multiplexed pcr with increased sensitivity
WO2023278410A1 (en) 2021-06-29 2023-01-05 Korro Bio, Inc. Methods and compositions for adar-mediated editing
WO2023275590A1 (en) 2021-06-29 2023-01-05 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Detection of phosphoinositides in blood cells as a biomarker for alpha synuclein associated pathologies and a method of treatment of parkinson's disease and the related neurodegenerations
US20230194709A9 (en) 2021-06-29 2023-06-22 Seagate Technology Llc Range information detection using coherent pulse sets with selected waveform characteristics
AU2022305653A1 (en) 2021-06-30 2024-01-18 Dana-Farber Cancer Institute, Inc. Compositions and methods for enrichment of nucleic acids using light-mediated cross-linking
AU2022304654A1 (en) 2021-07-01 2023-12-14 Gen-Probe Incorporated Enzyme formulations and reaction mixtures for nucleic acid amplification
CA3223344A1 (en) 2021-07-02 2023-01-05 Tropic Biosciences UK Limited Delay or prevention of browning in banana fruit
CA3224564A1 (en) 2021-07-05 2023-01-12 Andreas Holm MATTSSON Vaccines targeting neisseria gonorrhoeae
US20230040065A1 (en) 2021-07-09 2023-02-09 Janssen Biotech, Inc. Manufacturing Methods for Producing Anti-TNF Antibody Compositions
KR20240033032A (ko) 2021-07-09 2024-03-12 세페이드 높은 수준의 다중화 반응 용기, 시약 점적 장치 및 관련 방법
KR20240034215A (ko) 2021-07-09 2024-03-13 얀센 바이오테크 인코포레이티드 항-il12/il23 항체 조성물을 생산하기 위한 제조 방법
WO2023283442A1 (en) 2021-07-09 2023-01-12 10X Genomics, Inc. Methods for detecting analytes using sparse labelling
IL310226A (en) 2021-07-18 2024-03-01 Gamida Cell Ltd NK cell populations for treatment
GB202110485D0 (en) 2021-07-21 2021-09-01 Dnae Diagnostics Ltd Compositions, kits and methods for sequencing target polynucleotides
KR20240036041A (ko) 2021-07-21 2024-03-19 알닐람 파마슈티칼스 인코포레이티드 대사 장애-연관 표적 유전자 iRNA 조성물 및 이의 사용 방법
CA3226451A1 (en) 2021-07-21 2023-01-26 Sam Reed Method and system comprising a cartridge for sequencing target polynucleotides
GB202110479D0 (en) 2021-07-21 2021-09-01 Dnae Diagnostics Ltd Compositions, kits and methods for sequencing target polynucleotides
IL310256A (en) 2021-07-21 2024-03-01 Seegene Inc Complex analysis system, method and computer-readable recording means
IL309905A (en) 2021-07-23 2024-03-01 Alnylam Pharmaceuticals Inc IRNA compositions in β-catenin (CTNNB1) and methods of using them
WO2023010008A1 (en) 2021-07-27 2023-02-02 Gen-Probe Incorporated Compositions and methods for detecting gastrointestinal pathogens
WO2023009687A1 (en) 2021-07-29 2023-02-02 Alnylam Pharmaceuticals, Inc. 3-hydroxy-3-methylglutaryl-coa reductase (hmgcr) irna compositions and methods of use thereof
CA3187918A1 (en) 2021-07-30 2023-01-30 Helaina, Inc. Methods and compositions for protein synthesis and secretion
WO2023012627A1 (en) 2021-08-02 2023-02-09 Pfizer Inc. Improved expression vectors and uses thereof
WO2023012798A2 (en) 2021-08-02 2023-02-09 Yeda Research And Development Co. Ltd. Antibodies for the treatment of cancer
CA3226947A1 (en) 2021-08-03 2023-02-09 Muhammad YASSIN Engineered tcr complex and methods of using same
WO2023014677A1 (en) 2021-08-03 2023-02-09 Alnylam Pharmaceuticals, Inc. Transthyretin (ttr) irna compositions and methods of use thereof
US20230057571A1 (en) 2021-08-03 2023-02-23 10X Genomics, Inc. Nucleic acid concatemers and methods for stabilizing and/or compacting the same
EP4130028A1 (en) 2021-08-03 2023-02-08 Rhazes Therapeutics Ltd Engineered tcr complex and methods of using same
GB202111193D0 (en) 2021-08-03 2021-09-15 Phoremost Ltd Pharmaceutical compounds
AU2022324708A1 (en) 2021-08-06 2024-02-15 Kws Vegetables B.V. Durable downy mildew resistance in spinach
WO2023018621A1 (en) 2021-08-10 2023-02-16 Gamida-Cell Ltd. Engineered nk cells, methods of their production and uses thereof
TW202334413A (zh) 2021-08-13 2023-09-01 美商艾拉倫製藥股份有限公司 第十二因子（Ｆ１２）ｉＲＮＡ組成物及其使用方法
EP4134450A1 (en) 2021-08-13 2023-02-15 Genincode Uk Limited Prediction of cancer-associated venous thromboembolism
EP4326898A1 (en) 2021-08-16 2024-02-28 10X Genomics, Inc. Probes comprising a split barcode region and methods of use
WO2023021330A1 (en) 2021-08-16 2023-02-23 University Of Oslo Compositions and methods for determining a treatment course of action
WO2023023122A1 (en) 2021-08-18 2023-02-23 Life Technologies Corporation Immune repertoire biomarkers for prediction of treatment response in autoimmune disease
WO2023034489A1 (en) 2021-09-01 2023-03-09 10X Genomics, Inc. Methods, compositions, and kits for blocking a capture probe on a spatial array
GB202112866D0 (en) 2021-09-09 2021-10-27 Tropic Biosciences Uk Ltd Resistance to fusarium wilt in a banana
GB202112865D0 (en) 2021-09-09 2021-10-27 Tropic Biosciences Uk Ltd Resistance to black sigatoka disease in banana
US11395470B1 (en) 2021-09-14 2022-07-26 Equi-Nom Ltd. Sesame with high oil content and/or high yield
US20230193406A1 (en) 2021-09-22 2023-06-22 Herbalife International Of America, Inc. Methods and compositions for processing botanical materials
US20230101409A1 (en) 2021-09-30 2023-03-30 Microsoft Technology Licensing, Llc Anti-counterfeit tags using high-complexity polynucleotides
US20230101083A1 (en) 2021-09-30 2023-03-30 Microsoft Technology Licensing, Llc Anti-counterfeit tags using base ratios of polynucleotides
WO2023052622A1 (en) 2021-10-01 2023-04-06 Qiagen Gmbh Method of examining a nucleic acid amplification product
CA3234642A1 (en) 2021-10-04 2023-04-13 Poseida Therapeutics, Inc. Transposases and uses thereof
TW202333720A (zh) 2021-10-12 2023-09-01 美商塔里斯生物醫學有限責任公司 用於膀胱內施用的厄達替尼調配物及系統
CA3234887A1 (en) 2021-10-15 2023-04-20 Alnylam Pharmaceuticals, Inc. Extra-hepatic delivery irna compositions and methods of use thereof
WO2023067597A1 (en) 2021-10-18 2023-04-27 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Use of nanopore sequencing for determining the origin of circulating dna
WO2023069604A1 (en) 2021-10-20 2023-04-27 Life Technologies Corporation Compositions, kits, and methods for quantification of nucleic acid sequences using an internal quantitative standard
AU2022370883A1 (en) 2021-10-22 2024-04-18 Amgen Inc. Rnai constructs for inhibiting gpam expression and methods of use thereof
NL2030206B1 (en) 2021-10-25 2023-05-16 Sestina Bio Llc Heterologous expression of enzymes for increased b-farnesene production
TW202334418A (zh) 2021-10-29 2023-09-01 美商艾拉倫製藥股份有限公司 杭丁頓（ＨＴＴ）ｉＲＮＡ劑組成物及其使用方法
AR127477A1 (es) 2021-10-29 2024-01-31 Alnylam Pharmaceuticals Inc COMPOSICIONES DE ARNi CONTRA EL FACTOR B DEL COMPLEMENTO (CFB) Y MÉTODOS DE USO DE LAS MISMAS
WO2023073615A1 (en) 2021-10-29 2023-05-04 Janssen Biotech, Inc. Methods of treating crohn's disease with anti-il23 specific antibody
WO2023079430A1 (en) 2021-11-02 2023-05-11 Pfizer Inc. Methods of treating mitochondrial myopathies using anti-gdf15 antibodies
WO2023081221A1 (en) 2021-11-02 2023-05-11 Life Technologies Corporation Compositions and methods for reducing master mix contamination
WO2023079553A1 (en) 2021-11-03 2023-05-11 Biond Biologics Ltd. Intracellular delivery compositions
WO2023079032A1 (en) 2021-11-05 2023-05-11 F. Hoffmann-La Roche Ag Compositions and methods for detection of malaria
US20230151087A1 (en) 2021-11-15 2023-05-18 Janssen Biotech, Inc. Methods of Treating Crohn's Disease with Anti-IL23 Specific Antibody
US20230159633A1 (en) 2021-11-23 2023-05-25 Janssen Biotech, Inc. Method of Treating Ulcerative Colitis with Anti-IL23 Specific Antibody
GB202117405D0 (en) 2021-12-02 2022-01-19 Univ London Queen Mary Peptide
GB2613386A (en) 2021-12-02 2023-06-07 Apis Assay Tech Limited Diagnostic test
WO2023105526A1 (en) 2021-12-08 2023-06-15 Yeda Research And Development Co. Ltd. Multipotent lung progenitor cells for lung regeneration
WO2023104812A1 (en) 2021-12-09 2023-06-15 F. Hoffmann-La Roche Ag Mass based detection of pcr amplicons
US20230193310A1 (en) 2021-12-10 2023-06-22 Seminis Vegetabe Seeds, Inc. Lettuce plants having resistance to downy mildew
EP4194568A1 (en) 2021-12-10 2023-06-14 Genincode Uk Limited Covid-19-associated venous thromboembolism
WO2023114543A2 (en) 2021-12-17 2023-06-22 Dana-Farber Cancer Institute, Inc. Platform for antibody discovery
TW202342498A (zh) 2021-12-17 2023-11-01 美商薩那生物科技公司 經修飾副黏液病毒科融合醣蛋白
WO2023114544A1 (en) 2021-12-17 2023-06-22 Dana-Farber Cancer Institute, Inc. Antibodies and uses thereof
WO2023115041A1 (en) 2021-12-17 2023-06-22 Sana Biotechnology, Inc. Modified paramyxoviridae attachment glycoproteins
WO2023122762A1 (en) 2021-12-22 2023-06-29 Camp4 Therapeutics Corporation Modulation of gene transcription using antisense oligonucleotides targeting regulatory rnas
WO2023122758A1 (en) 2021-12-22 2023-06-29 Cornell University Prognostic/predictive epigenetic breast cancer signature
WO2023119301A1 (en) 2021-12-26 2023-06-29 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Methods of screening and treating fragile x syndrome
WO2023129898A2 (en) 2021-12-27 2023-07-06 10X Genomics, Inc. Methods and compositions for rolling circle amplification
US20230279475A1 (en) 2022-01-21 2023-09-07 10X Genomics, Inc. Multiple readout signals for analyzing a sample
WO2023144798A1 (en) 2022-01-31 2023-08-03 Genevant Sciences Gmbh Ionizable cationic lipids for lipid nanoparticles
WO2023144792A1 (en) 2022-01-31 2023-08-03 Genevant Sciences Gmbh Poly(alkyloxazoline)-lipid conjugates and lipid particles containing same
WO2023148732A1 (en) 2022-02-01 2023-08-10 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Method for selecting an improved genetically modified plant
WO2023154678A1 (en) 2022-02-08 2023-08-17 Amgen Inc. Codon-optimized nucleic acids encoding ocrelizumab
WO2023152568A2 (en) 2022-02-10 2023-08-17 Oslo Universitetssykehus Hf Compositions and methods for characterizing lung cancer
WO2023158732A1 (en) 2022-02-16 2023-08-24 Dana-Farber Cancer Institute, Inc. Methods for decreasing pathologic alpha-synuclein using agents that modulate fndc5 or biologically active fragments thereof
WO2023164573A1 (en) 2022-02-23 2023-08-31 Poseida Therapeutics, Inc. Genetically modified cells and methods of use thereof
US20240117030A1 (en) 2022-03-03 2024-04-11 Pfizer Inc. Multispecific antibodies and uses thereof
WO2023172694A1 (en) 2022-03-09 2023-09-14 Dana-Farber Cancer Institute, Inc. Genetically engineered b cells and methods of use thereof
WO2023177655A1 (en) 2022-03-14 2023-09-21 Generation Bio Co. Heterologous prime boost vaccine compositions and methods of use
US20230295661A1 (en) 2022-03-16 2023-09-21 University Of Houston System Persistent hsv gene delivery system
US20230346934A1 (en) 2022-03-29 2023-11-02 Allogene Therapeutics, Inc. Chimeric switch receptors for the conversion of immunesuppressive signals to costimulatory signals
GB202204595D0 (en) 2022-03-30 2022-05-11 Univ Newcastle Methods dor determining mitochondrial DNA damage
WO2023192616A1 (en) 2022-04-01 2023-10-05 10X Genomics, Inc. Compositions and methods for targeted masking of autofluorescence
WO2023187760A1 (en) 2022-04-01 2023-10-05 Genevant Sciences Gmbh Mannose-targeted compositions
WO2023196884A1 (en) 2022-04-06 2023-10-12 Juno Therapeutics, Inc. Detection assay for human papillomavirus (hpv) type 16 (hpv-16)
WO2023196476A1 (en) 2022-04-06 2023-10-12 University Of Massachusetts Compositions and methods of prime editor guide rna/sequencing tag complexes
US20230357851A1 (en) 2022-04-06 2023-11-09 Larimar Therapeutics, Inc. Frataxin-sensitive markers for monitoring frataxin-replacement therapy
US20230323427A1 (en) 2022-04-06 2023-10-12 10X Genomics, Inc. Methods and compositions for multiplex cell analysis
WO2023196572A1 (en) 2022-04-07 2023-10-12 Illumina Singapore Pte. Ltd. Altered cytidine deaminases and methods of use
WO2023195009A1 (en) 2022-04-07 2023-10-12 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Genetically modified bacteria and use thereof
WO2023201230A1 (en) 2022-04-11 2023-10-19 The Regents Of The University Of California Methods of screening for plant gain of function mutations and compositions therefor
WO2023201207A1 (en) 2022-04-11 2023-10-19 Tenaya Therapeutics, Inc. Adeno-associated virus with engineered capsid
US11680293B1 (en) 2022-04-21 2023-06-20 Paragon Genomics, Inc. Methods and compositions for amplifying DNA and generating DNA sequencing results from target-enriched DNA molecules
WO2023209708A1 (en) 2022-04-25 2023-11-02 Yeda Research And Development Co. Ltd. Compositions for altering cyclic adp-ribose secondary messenger signalling
WO2023209716A1 (en) 2022-04-25 2023-11-02 Biond Biologics Ltd. Anti-ilt3 antibodies and use thereof
WO2023209070A1 (en) 2022-04-29 2023-11-02 Novozymes A/S Production of fatty acid alkyl esters
WO2023214405A1 (en) 2022-05-01 2023-11-09 Yeda Research And Development Co. Ltd. Reexpression of hnf4a to alleviate cancer-associated cachexia
WO2023215860A1 (en) 2022-05-05 2023-11-09 University Of Rochester Modified bacteria and methods of use for bioglass microlenses
WO2023214346A1 (en) 2022-05-06 2023-11-09 Novartis Ag Novel recombinant aav vp2 fusion polypeptides
WO2023218450A1 (en) 2022-05-09 2023-11-16 Yeda Research And Development Co. Ltd. A commensal fungus and uses thereof
WO2023225515A1 (en) 2022-05-17 2023-11-23 Life Technologies Corporation Compositions and methods for oncology assays
WO2023223092A1 (en) 2022-05-18 2023-11-23 Institut Pasteur Identification of a human circovirus
WO2023223265A1 (en) 2022-05-18 2023-11-23 Janssen Biotech, Inc. Method for evaluating and treating psoriatic arthritis with il23 antibody
EP4282980A1 (en) 2022-05-23 2023-11-29 Mobidiag Oy Methods for amplifying a nucleic acid
WO2023230531A1 (en) 2022-05-24 2023-11-30 Lunglife Ai, Inc. Methods for detecting circulating genetically abnormal cells
GB202208171D0 (en) 2022-06-01 2022-07-13 Institute Of Cancer Res Method
WO2023233413A1 (en) 2022-06-01 2023-12-07 Yeda Research And Development Co. Ltd. eIF4G1-eIF1 INHIBITORS AND USE THEREOF
US20230392207A1 (en) 2022-06-03 2023-12-07 Illumina, Inc. Circulating rna biomarkers for preeclampsia
WO2023238131A1 (en) 2022-06-07 2023-12-14 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Methods of treating x-linked genetic diseases
WO2023240218A1 (en) 2022-06-09 2023-12-14 Allogene Therapeutics Inc. Methods for detecting genomic abnormalities in cells
WO2023240277A2 (en) 2022-06-10 2023-12-14 Camp4 Therapeutics Corporation Methods of modulating progranulin expression using antisense oligonucleotides targeting regulatory rnas
US20240010742A1 (en) 2022-06-10 2024-01-11 Research Development Foundation Engineered fcriib selective igg1 fc variants and uses thereof
US20230404003A1 (en) 2022-06-21 2023-12-21 Seminis Vegetable Seeds, Inc. Novel qtls conferring resistance to cucumber mosaic virus
WO2024002924A2 (en) 2022-06-28 2024-01-04 F. Hoffmann-La Roche Ag Fluorescent dyes with large stokes shift
WO2024006927A1 (en) 2022-06-29 2024-01-04 Life Technologies Corporation Compositions, kits, and methods for detecting nucleic acids using intra-channel multiplexing
US20240003871A1 (en) 2022-06-29 2024-01-04 FUJIFILM Cellular Dynamics, Inc. Ipsc-derived astrocytes and methods of use thereof
WO2024006924A1 (en) 2022-06-29 2024-01-04 Life Technologies Corporation Systems and methods for analyte detection from multiplexed assays
WO2024003332A1 (en) 2022-06-30 2024-01-04 F. Hoffmann-La Roche Ag Controlling for tagmentation sequencing library insert size using archaeal histone-like proteins
WO2024013742A1 (en) 2022-07-11 2024-01-18 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Improving adoptive cell transfer therapy (act) treatment
WO2024015766A1 (en) 2022-07-12 2024-01-18 Topogene Inc. Scalable, submicron-resolution replication of dna arrays
US20240042030A1 (en) 2022-07-29 2024-02-08 Allogene Therapeutics, Inc. Engineered cells with reduced gene expression to mitigate immune cell recognition
WO2024030345A1 (en) 2022-08-05 2024-02-08 Life Technologies Corporation Compositions, kits, and methods for detection of variant strains of african swine fever virus
WO2024036304A1 (en) 2022-08-12 2024-02-15 10X Genomics, Inc. Puma1 polymerases and uses thereof
WO2024040041A1 (en) 2022-08-15 2024-02-22 Dicerna Pharmaceuticals, Inc. Regulation of activity of rnai molecules
US20240084373A1 (en) 2022-08-16 2024-03-14 10X Genomics, Inc. Ap50 polymerases and uses thereof
WO2024038457A1 (en) 2022-08-18 2024-02-22 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. A method for determining the tissue or cell of origin of dna
WO2024039776A2 (en) 2022-08-18 2024-02-22 Alnylam Pharmaceuticals, Inc. Universal non-targeting sirna compositions and methods of use thereof
WO2024040222A1 (en) 2022-08-19 2024-02-22 Generation Bio Co. Cleavable closed-ended dna (cedna) and methods of use thereof
WO2024050308A1 (en) 2022-08-29 2024-03-07 Microgenics Corporation Cell-free total nucleic acid controls
WO2024046992A1 (en) 2022-09-02 2024-03-07 F. Hoffmann-La Roche Ag Improvements to next-generation target enrichment performance
WO2024054924A1 (en) 2022-09-08 2024-03-14 Gen-Probe Incorporated Method of detecting nucleic acid analytes using dual-specificity primers
WO2024054925A1 (en) 2022-09-09 2024-03-14 Life Technologies Corporation Compositions, kits and methods for detection of viral variant sequences
WO2024057190A2 (en) 2022-09-12 2024-03-21 Genevant Sciences Gmbh Targeted compositions
WO2024064838A1 (en) 2022-09-21 2024-03-28 Sana Biotechnology, Inc. Lipid particles comprising variant paramyxovirus attachment glycoproteins and uses thereof
WO2024069581A1 (en) 2022-09-30 2024-04-04 Illumina Singapore Pte. Ltd. Helicase-cytidine deaminase complexes and methods of use
WO2024073047A1 (en) 2022-09-30 2024-04-04 Illumina, Inc. Cytidine deaminases and methods of use in mapping modified cytosine nucleotides
WO2024073043A1 (en) 2022-09-30 2024-04-04 Illumina, Inc. Methods of using cpg binding proteins in mapping modified cytosine nucleotides
WO2024077162A2 (en) 2022-10-06 2024-04-11 Illumina, Inc. Probes for improving coronavirus sample surveillance
WO2024077202A2 (en) 2022-10-06 2024-04-11 Illumina, Inc. Probes for improving environmental sample surveillance
WO2024077152A1 (en) 2022-10-06 2024-04-11 Illumina, Inc. Probes for depleting abundant small noncoding rna

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4351901A (en) * 1980-03-24 1982-09-28 Cetus Corporation Method for single nucleotide alteration
ZA811368B (en) * 1980-03-24 1982-04-28 Genentech Inc Bacterial polypedtide expression employing tryptophan promoter-operator
EP0138242A1 (en) * 1983-09-07 1985-04-24 Duphar International Research B.V Method of preparing DNA complementary to the genome of coronaviruses
AU577334B2 (en) * 1983-10-11 1988-09-22 International Genetic Engineering, Inc. Synthetic thaumatin genes
US4711848A (en) * 1984-03-14 1987-12-08 Zymogenetics, Inc. Site specific mutagenesis in alpha-1-antitrypsin

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