ATE519783T1 - ßPHAGE DISPLAYß BIBLIOTHEKE VON MENSCHLICHEN VH FRAGMENTEN - Google Patents
ßPHAGE DISPLAYß BIBLIOTHEKE VON MENSCHLICHEN VH FRAGMENTENInfo
- Publication number
- ATE519783T1 ATE519783T1 AT01271932T AT01271932T ATE519783T1 AT E519783 T1 ATE519783 T1 AT E519783T1 AT 01271932 T AT01271932 T AT 01271932T AT 01271932 T AT01271932 T AT 01271932T AT E519783 T1 ATE519783 T1 AT E519783T1
- Authority
- AT
- Austria
- Prior art keywords
- fragments
- ßphage
- displayß
- library
- human
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/02—Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/005—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3053—Skin, nerves, brain
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/735—Fusion polypeptide containing domain for protein-protein interaction containing a domain for self-assembly, e.g. a viral coat protein (includes phage display)
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Virology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Neurology (AREA)
- Physics & Mathematics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Plant Pathology (AREA)
- Cell Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25803100P | 2000-12-22 | 2000-12-22 | |
| PCT/CA2001/001845 WO2002051870A2 (en) | 2000-12-22 | 2001-12-21 | Phage display libraries of human vh fragments |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE519783T1 true ATE519783T1 (de) | 2011-08-15 |
Family
ID=22978807
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01271932T ATE519783T1 (de) | 2000-12-22 | 2001-12-21 | ßPHAGE DISPLAYß BIBLIOTHEKE VON MENSCHLICHEN VH FRAGMENTEN |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US8372954B2 (de) |
| EP (1) | EP1345967B1 (de) |
| AT (1) | ATE519783T1 (de) |
| CA (1) | CA2447832C (de) |
| ES (1) | ES2376454T3 (de) |
| WO (1) | WO2002051870A2 (de) |
Families Citing this family (69)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100430534B1 (ko) * | 2001-05-23 | 2004-05-10 | 주식회사 마이크로아이디 | 단일가닥 디엔에이 분해효소를 이용하여 키메라 디엔에이라이브러리를 만드는 방법 |
| US9321832B2 (en) | 2002-06-28 | 2016-04-26 | Domantis Limited | Ligand |
| GB0230203D0 (en) * | 2002-12-27 | 2003-02-05 | Domantis Ltd | Fc fusion |
| SI1639011T1 (sl) * | 2003-06-30 | 2009-04-30 | Domantis Ltd | Pegilirana protitelesa z enojno domeno (dAb) |
| US8293233B2 (en) * | 2005-03-25 | 2012-10-23 | National Research Council Of Canada | Method for isolation of soluble polypeptides |
| WO2009109572A2 (en) * | 2008-03-03 | 2009-09-11 | Ablynx Nv | Monovalent phage display of single variable domains |
| PE20120591A1 (es) | 2009-04-02 | 2012-05-23 | Roche Glycart Ag | Anticuerpos multiespecificos que comprenden anticuerpos de longitud completa y fragmentos fab de cadena sencilla |
| WO2011034605A2 (en) | 2009-09-16 | 2011-03-24 | Genentech, Inc. | Coiled coil and/or tether containing protein complexes and uses thereof |
| MX2012006406A (es) | 2009-12-04 | 2012-07-25 | Genentech Inc | Anticuerpos multiespecificos, analogos de anticuerpo, composiciones y metodos. |
| EP2509626B1 (de) | 2009-12-11 | 2016-02-10 | F.Hoffmann-La Roche Ag | Anti-vegf-c-antikörper und verfahren zu ihrer verwendung |
| JP5852010B2 (ja) | 2009-12-23 | 2016-02-03 | ジェネンテック, インコーポレイテッド | 抗Bv8抗体およびその使用 |
| AR080793A1 (es) | 2010-03-26 | 2012-05-09 | Roche Glycart Ag | Anticuerpos biespecificos |
| US9637557B2 (en) | 2010-04-23 | 2017-05-02 | Genentech, Inc. | Production of heteromultimeric proteins |
| CN102959097B (zh) | 2010-07-08 | 2014-07-16 | 本田技研工业株式会社 | 高频加热用线圈 |
| CN104474546A (zh) | 2010-08-13 | 2015-04-01 | 弗·哈夫曼-拉罗切有限公司 | 用于疾病治疗的针对IL-1β和IL-18的抗体 |
| RU2013110875A (ru) | 2010-08-24 | 2014-09-27 | Ф.Хоффманн-Ля Рош Аг | БИСПЕЦИФИЧЕСКИЕ АНТИТЕЛА, СОДЕРЖАЩИЕ СТАБИЛИЗИРОВАННЫЙ ДИСУЛЬФИДОМ ФРАГМЕНТ Fv |
| US9675693B2 (en) | 2010-09-30 | 2017-06-13 | Riken | Methods and drugs targeting Eva1 or Ceacam1 gene expression for treatment and diagnosing of glioma |
| JP5766296B2 (ja) | 2010-12-23 | 2015-08-19 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | ポリペプチド−ポリヌクレオチド複合体、およびエフェクター成分の標的化された送達におけるその使用 |
| JP5883396B2 (ja) | 2010-12-27 | 2016-03-15 | 国立大学法人名古屋大学 | 受容体型チロシンキナーゼが仲介する癌細胞の生存促進性シグナルを抑制する方法 |
| US10689447B2 (en) | 2011-02-04 | 2020-06-23 | Genentech, Inc. | Fc variants and methods for their production |
| CN103649117B (zh) | 2011-02-04 | 2016-09-14 | 霍夫曼-拉罗奇有限公司 | Fc变体及其生成方法 |
| JP5925783B2 (ja) | 2011-08-12 | 2016-05-25 | 国立感染症研究所長 | アスペルギルスフミガーツス感染症の検査、予防及び治療のための方法並びに組成物 |
| CN104093744A (zh) | 2011-10-11 | 2014-10-08 | 弗·哈夫曼-拉罗切有限公司 | 双特异性抗体的改进的组装 |
| MX2014005330A (es) | 2011-11-02 | 2014-09-08 | Genentech Inc | Cromatografia de sobrecarga y elucion. |
| MX2014009565A (es) | 2012-02-10 | 2014-11-10 | Genentech Inc | Anticuerpos monocatenarios y otros heteromultimeros. |
| JP6263117B2 (ja) | 2012-05-11 | 2018-01-17 | 公益財団法人微生物化学研究会 | 抗cxadr抗体 |
| JP6203838B2 (ja) | 2012-06-27 | 2017-09-27 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | 少なくとも2つの異なる結合実体を含む、テーラーメイドの高度に選択的かつ多重特異的なターゲティング実体を選択および作製するための方法、ならびにその使用 |
| RU2015100656A (ru) | 2012-06-27 | 2016-08-20 | Ф. Хоффманн-Ля Рош Аг | Способ получения конъюгатов fc-фрагмента антитела, включающих по меньшей мере одну связывающую группировку, которая специфически связывается с мишенью, и их применения |
| EP2881467B1 (de) | 2012-07-30 | 2018-10-31 | National University Corporation Nagoya University | Monoklonaler antikörper gegen menschlichen midkine |
| KR101796689B1 (ko) * | 2012-08-22 | 2017-11-10 | 재단법인 목암생명과학연구소 | 안정화된 면역글로불린가변도메인 선별방법 및 선별된 도메인의 응용 |
| RU2015122726A (ru) | 2012-11-15 | 2017-01-10 | Дженентек, Инк. | ОПОСРЕДОВАННАЯ ИОННОЙ СИЛОЙ рН-ГРАДИЕНТНАЯ ИОНООБМЕННАЯ ХРОМАТОГРАФИЯ |
| JP6357113B2 (ja) | 2013-02-08 | 2018-07-11 | 株式会社医学生物学研究所 | ヒトnrg1タンパク質に対する抗体 |
| US9429584B2 (en) | 2013-02-28 | 2016-08-30 | National Cancer Center | Antibody against insoluble fibrin |
| WO2014174596A1 (ja) | 2013-04-23 | 2014-10-30 | 株式会社医学生物学研究所 | ヘパリン結合上皮増殖因子様増殖因子に対する機能性モノクローナル抗体 |
| HRP20190071T1 (hr) | 2013-07-12 | 2019-02-22 | F. Hoffmann - La Roche Ag | Elucidacija optimizacije unosa kromatografijom ionske izmjene |
| CN105848746B (zh) | 2013-09-05 | 2019-07-09 | 豪夫迈·罗氏有限公司 | 用于层析重复利用的方法 |
| SG10201802525QA (en) | 2013-09-13 | 2018-04-27 | Genentech Inc | Methods and compositions comprising purified recombinant polypeptides |
| KR102332302B1 (ko) | 2013-09-13 | 2021-12-01 | 제넨테크, 인크. | 세포주에서 숙주 세포 단백질 및 재조합 폴리펩티드 생성물을 검출 및 정량화하기 위한 조성물 및 방법 |
| EP3070167A4 (de) | 2013-11-06 | 2017-06-07 | Osaka University | Antikörper mit breiter neutralisierender aktivität bei einem gruppe-1-influenza-a-virus |
| HUE063273T2 (hu) | 2014-05-06 | 2024-01-28 | Hoffmann La Roche | Heteromultimer fehérjék elõállítása emlõssejtek felhasználásával |
| EP3217787B1 (de) | 2014-11-10 | 2019-04-17 | F.Hoffmann-La Roche Ag | Tiermodell für nephropathie und mittel zur behandlung davon |
| WO2016087416A1 (en) | 2014-12-03 | 2016-06-09 | F. Hoffmann-La Roche Ag | Multispecific antibodies |
| ES2761726T3 (es) | 2015-03-06 | 2020-05-20 | Hoffmann La Roche | DsbA y DsbC ultrapurificadas y procedimientos de preparación y uso de las mismas |
| MX2017012805A (es) | 2015-04-07 | 2018-04-11 | Genentech Inc | Complejo de unión a antígenos con actividad agonista y métodos de uso. |
| EP3795679A1 (de) | 2015-05-28 | 2021-03-24 | Genentech, Inc. | Zellbasierter test zum nachweis von anti-cd3-homodimeren |
| EP3408671B1 (de) | 2016-01-25 | 2023-11-01 | F. Hoffmann-La Roche AG | Verfahren zum testen t-zell-abhängiger bispezifischer antikörper |
| EP3434690A4 (de) | 2016-03-23 | 2020-04-01 | Seoul National University R&DB Foundation | An hüllglykoprotein von schwerem-fieber-mit-thrombozytopenie-syndrom-virus bindender antikörper sowie verwendung dafür |
| JP7359547B2 (ja) | 2016-05-17 | 2023-10-11 | ジェネンテック, インコーポレイテッド | 免疫療法における診断及び使用のための間質遺伝子シグネチャー |
| ES2988363T3 (es) | 2016-06-17 | 2024-11-20 | Hoffmann La Roche | Purificación de anticuerpos multiespecíficos |
| EP3475700A4 (de) | 2016-06-26 | 2020-03-04 | Gennova Biopharmaceuticals Limited | Antikörper-phagendisplay-bibliothek |
| EP3494139B1 (de) | 2016-08-05 | 2022-01-12 | F. Hoffmann-La Roche AG | Multivalente und multiepitopische anitikörper mit agonistischer wirkung und verfahren zur verwendung |
| JP6293829B2 (ja) * | 2016-08-05 | 2018-03-14 | モガム インスティチュート フォー バイオメディカル リサーチMOGAM Institute for Biomedical Research | 安定化された免疫グロブリン可変ドメイン選別方法及び選別されたドメインの応用 |
| SG11201901228QA (en) | 2016-08-15 | 2019-03-28 | Genentech Inc | Chromatography method for quantifying a non-ionic surfactant in a composition comprising the non-ionic surfactant and a polypeptide |
| WO2020059847A1 (ja) | 2018-09-21 | 2020-03-26 | 国立大学法人 東京医科歯科大学 | ヒトhmgb1に特異的に結合するヒトモノクローナル抗体、及びそれを含有するアルツハイマー病を治療又は予防するための医薬組成物 |
| JP7607579B2 (ja) | 2019-03-27 | 2024-12-27 | ティガティーエックス, インコーポレイテッド | 工学的に操作されたIgA抗体および使用方法 |
| CN113711037A (zh) | 2019-04-18 | 2021-11-26 | 基因泰克公司 | 抗体效力测定 |
| TWI870412B (zh) | 2019-06-05 | 2025-01-21 | 美商建南德克公司 | 過載層析管柱之再生方法 |
| CA3173263A1 (en) | 2020-03-30 | 2021-10-07 | Yasuhiro Matsumura | Antibody drug conjugate |
| EP4158014A2 (de) | 2020-05-26 | 2023-04-05 | Dionis Therapeutics, Inc. | Bibliotheken künstlicher mini-proteome aus nukleinsäuren |
| KR20230073196A (ko) | 2020-09-21 | 2023-05-25 | 제넨테크, 인크. | 다중특이성 항체의 정제 |
| US20240025985A1 (en) | 2020-12-09 | 2024-01-25 | National University Corporation Tokyo Medical And Dental University | Agent for Preventing or Treating Frontotemporal Lobar Degeneration |
| CN116745620A (zh) | 2021-01-14 | 2023-09-12 | 国立大学法人新潟大学 | 用于辅助肾病综合征的诊断的标志物及其应用 |
| EP4426829A1 (de) | 2021-11-01 | 2024-09-11 | Dana-Farber Cancer Institute, Inc. | Biologisch ausgewählte bibliotheken künstlicher miniproteome von nukleinsäuren |
| CN119213128A (zh) | 2022-03-09 | 2024-12-27 | 株式会社丘阿德 | 与Eva1蛋白质结合的人源化抗体或其功能性片段、抗体药物缀合物和嵌合抗原受体 |
| WO2023192622A1 (en) | 2022-04-01 | 2023-10-05 | Genentech, Inc. | Hydroxypropyl methyl cellulose derivatives to stabilize polypeptides |
| WO2023238869A1 (ja) | 2022-06-07 | 2023-12-14 | 国立大学法人 東京医科歯科大学 | 筋萎縮性側索硬化症、パーキンソン病、ハンチントン病、脊髄小脳失調症、老化に関連する変性疾患若しくは神経疾患、脳老化、あるいは脳老化を伴う疾患の予防剤又は治療剤 |
| EP4619755A1 (de) | 2022-11-18 | 2025-09-24 | Genentech, Inc. | Signalverstärkung und multiplexing unter verwendung von massenetiketten für ia-lc-ms/ms-basierte assays |
| KR20250116683A (ko) | 2022-11-25 | 2025-08-01 | 고꾸리쯔 다이가꾸 호우징 오사까 다이가꾸 | 혈액암에 대한 항체 |
| KR20250134225A (ko) | 2023-01-18 | 2025-09-10 | 니혼 유니버서티 | 점막 병변 환자에 대한 면역요법약에 의한 치료의 유효성을 예측하기 위한 방법 및 키트 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4593002A (en) | 1982-01-11 | 1986-06-03 | Salk Institute Biotechnology/Industrial Associates, Inc. | Viruses with recombinant surface proteins |
| US4754065A (en) | 1984-12-18 | 1988-06-28 | Cetus Corporation | Precursor to nucleic acid probe |
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4800159A (en) | 1986-02-07 | 1989-01-24 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences |
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| DE69129154T2 (de) | 1990-12-03 | 1998-08-20 | Genentech, Inc., South San Francisco, Calif. | Verfahren zur anreicherung von proteinvarianten mit geänderten bindungseigenschaften |
| EP1498427B1 (de) | 1992-08-21 | 2009-12-16 | Vrije Universiteit Brussel | Immunoglobuline ohne leichte Ketten |
| US5639863A (en) | 1994-06-21 | 1997-06-17 | Dan; Michael D. | Human monoclonal antibodies specific to cell cycle independent glioma surface antigen |
| US5702892A (en) | 1995-05-09 | 1997-12-30 | The United States Of America As Represented By The Department Of Health And Human Services | Phage-display of immunoglobulin heavy chain libraries |
| US6828422B1 (en) * | 1995-08-18 | 2004-12-07 | Morphosys Ag | Protein/(poly)peptide libraries |
| IL127127A0 (en) * | 1998-11-18 | 1999-09-22 | Peptor Ltd | Small functional units of antibody heavy chain variable regions |
| WO2001018058A2 (en) | 1999-09-07 | 2001-03-15 | Viventia Biotech Inc. | Enhanced phage display library of human vh fragments and methods for producing same |
| DE60143798D1 (de) * | 2000-06-16 | 2011-02-17 | Cambridge Antibody Tech | Immunspezifisch bindende antikörper gegen blys |
| WO2002028903A2 (en) * | 2000-09-13 | 2002-04-11 | Crucell Holland B.V. | Heavy chain libraries |
-
2001
- 2001-12-21 EP EP01271932A patent/EP1345967B1/de not_active Expired - Lifetime
- 2001-12-21 WO PCT/CA2001/001845 patent/WO2002051870A2/en not_active Ceased
- 2001-12-21 CA CA2447832A patent/CA2447832C/en not_active Expired - Fee Related
- 2001-12-21 AT AT01271932T patent/ATE519783T1/de not_active IP Right Cessation
- 2001-12-21 US US10/451,585 patent/US8372954B2/en not_active Expired - Fee Related
- 2001-12-21 ES ES01271932T patent/ES2376454T3/es not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CA2447832C (en) | 2012-09-25 |
| CA2447832A1 (en) | 2002-07-04 |
| EP1345967B1 (de) | 2011-08-10 |
| WO2002051870A3 (en) | 2003-04-24 |
| WO2002051870A2 (en) | 2002-07-04 |
| EP1345967A2 (de) | 2003-09-24 |
| ES2376454T3 (es) | 2012-03-14 |
| US8372954B2 (en) | 2013-02-12 |
| US20050164180A1 (en) | 2005-07-28 |
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