SG11201810332TA - Neoepitope vaccine compositions and methods of use thereof - Google Patents

Neoepitope vaccine compositions and methods of use thereof

Info

Publication number
SG11201810332TA
SG11201810332TA SG11201810332TA SG11201810332TA SG11201810332TA SG 11201810332T A SG11201810332T A SG 11201810332TA SG 11201810332T A SG11201810332T A SG 11201810332TA SG 11201810332T A SG11201810332T A SG 11201810332TA SG 11201810332T A SG11201810332T A SG 11201810332TA
Authority
SG
Singapore
Prior art keywords
international
neo
methods
jefferson
boulevard
Prior art date
Application number
SG11201810332TA
Inventor
Frank Jones
Adrian Rice
Patrick Soon-Shiong
Kayvan Niazi
Shahrooz Rabizadeh
Original Assignee
Etubics Corp
Nant Holdings Ip Llc
Nantcell Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Etubics Corp, Nant Holdings Ip Llc, Nantcell Inc filed Critical Etubics Corp
Publication of SG11201810332TA publication Critical patent/SG11201810332TA/en

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
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    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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Abstract

INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) CORRECTED VERSION ,,,,,,,,,1111.111.„ m„ Organization 11„ ,,,,,,„„,11,11„,,,,,,,,,,,,,111111111111111111111101111 (19) World Intellectual Property ---,. International Bureau (10) International Publication Number (43) International Publication Date ...../ WO 2017/205810 A8 30 November 2017 (30.11.2017) WIPO I PCT (51) International Patent Classification: SOON-SHIONG, Patrick; 9920 Jefferson Boulevard, Cul- A61K 39/00 (2006.01) C07K 14/705 (2006.01) ver City, CA 90232 (US). NIAZI, Kayvan; 9920 Jefferson C12N 15/86 (2006.01) Boulevard, Culver City, CA 90232 (US). RABIZADEH, (21) International Application Number: Shahrooz; 9920 Jefferson Boulevard, Culver City, CA PCT/US2017/034802 90232 (US). (22) International Filing Date: (74) Agent: RAMANATHAN, Renuka et al.; Wilson Sonsini 26 May 2017 (26.05.2017) Goodrich & Rosati, 650 Page Mill Road, Palo Alto, CA 94304-1050 (US). (25) Filing Language: English (81) Designated States (unless otherwise indicated, for every (26) Publication Language: English kind of national protection available): AE, AG, AL, AM, (30) Priority Data: AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, 62/342,752 27 May 2016 (27.05.2016) US CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, (71) Applicants: ETUBICS CORPORATION [US/US]; 410 HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, West Harrison Street, Suite 200, Seattle, WA 98119 (US). KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, NANT HOLDINGS IP, LLC [US/US]; 9922 Jefferson MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, Boulevard, Culver City, CA 90232 (US). NANTCELL, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, INC. [US/US]; 9920 Jefferson Boulevard, Culver City, CA SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, = 90232 (US). TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (72) Inventors: JONES, Frank, R.; 410 West Harrison Street, (84) Designated States (unless otherwise indicated, for every = Suite 200, Seattle, WA 98119 (US). RICE, Adrian; 410 kind of regional protection available): ARIPO (BW, GH, — West Harrison Street, Suite 200, Seattle, WA 98119 (US). GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, = — (54) Title: NEOEPITOPE VACCINE COMPOSITIONS AND METHODS OF USE THEREOF (57) : In certain embodiments, methods and compositions are pro- _ _ = Patient Sample —* Whole exome sequencing for mutations vided for generating immune responses against tumor neo-antigens or neo- epitopes. In particular embodiments there may be provided methods for con- = strutting and producing recombinant adenovirus-based vector vaccines con- taining nucleic acid sequences encoding tumor neo-antigens and neo-epitopes = — — - = =f - Translation of mutated sequence with centrally positioned (and corresponding WT peptide) mutant into 17mer amino acid that allow for vaccinations in individuals with preexisting immunity to aden- ovirus. In additional embodiments, methods and compositions are provided for the treatment of cancer using immunotherapy based on recombinant ade- killer cells. In = MHC Class I prediction novirus-based vectors combined with engineered natural some binding Analysis embodiments, the methods and compositions further comprises a nucleic acid — encoding for an immunological fusion partner. = — = IEBD Analysis homology to known epitopes from of or cancers i T cell interaction prediction (IEBD program) GC Peptides predicted to bind MHC Class I with IC505500 (- Peptides predicted toy bind MHC Class I with 1050.500 , or interact with T cell, © 11 GC kr) © Candidate Neo-antlgens or Neo-epltopes r'l --.... IN FIG. 1 1-1 0 r'l C [Continued on next page] WO 2017/205810 A8 MIDEDIMOMOIDEIROIDEMODIMINHOMMOVE# UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) — before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) (48) Date of publication of this corrected version: 04 January 2018 (04.01.2018) (15) Information about Correction: see Notice of 04 January 2018 (04.01.2018)
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Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108495649A (en) 2016-01-08 2018-09-04 瓦西博迪公司 The new epiposition vaccine of therapeutic anti-cancer
AU2017290803A1 (en) 2016-06-30 2019-01-24 Nant Holdings Ip, Llc Nant cancer vaccine
US20190321481A1 (en) * 2016-11-11 2019-10-24 Nantbio, Inc. Immunomodulatory compositions, processes for making the same, and methods for inhibiting cytokine storms
US11932676B2 (en) * 2016-11-22 2024-03-19 Klotho Therapeutics, Inc. Recombinant klotho proteins and compositions and methods involving same
US20190351039A1 (en) 2017-02-01 2019-11-21 Modernatx, Inc. Immunomodulatory therapeutic mrna compositions encoding activating oncogene mutation peptides
US11629340B2 (en) 2017-03-03 2023-04-18 Obsidian Therapeutics, Inc. DHFR tunable protein regulation
EP3596108A4 (en) 2017-03-15 2020-12-23 Pandion Operations, Inc. Targeted immunotolerance
BR112019024127A2 (en) 2017-05-24 2020-06-23 Pandion Therapeutics, Inc. TARGETED IMMUNOTOLERANCE
AU2018275147B2 (en) * 2017-06-02 2021-01-28 Etubics Corporation Compositions and methods for tumor vaccination and immunotherapy involving HER antigens
GB2574785A (en) 2017-09-15 2019-12-25 Jan Loetvall Method and system for identifying membrane proteins on extracellular vesicles
US10174092B1 (en) 2017-12-06 2019-01-08 Pandion Therapeutics, Inc. IL-2 muteins
US10946068B2 (en) 2017-12-06 2021-03-16 Pandion Operations, Inc. IL-2 muteins and uses thereof
CN111836639A (en) * 2018-01-26 2020-10-27 河谷细胞有限公司 Compositions and methods for combination cancer vaccine and immune adjuvant therapy
CN111867612A (en) 2018-03-26 2020-10-30 阿尔托生物科学有限责任公司 anti-PDL 1, IL-15 and TGF-beta receptor combination molecules
WO2019191494A1 (en) * 2018-03-28 2019-10-03 Epicentrx, Inc. Personalized cancer vaccines
US11564980B2 (en) 2018-04-23 2023-01-31 Nantcell, Inc. Tumor treatment method with an individualized peptide vaccine
TW202345890A (en) 2018-04-23 2023-12-01 美商南特細胞公司 Neoepitope vaccine and immune stimulant combinations and methods
KR20210005240A (en) * 2018-05-03 2021-01-13 보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템 Natural killer cells engineered to express chimeric antigen receptors with immune checkpoint blocking
EP3574915A1 (en) * 2018-05-29 2019-12-04 Neovacs Immunogenic product comprising il-4 and/or il-13 for treating disorders associated with aberrant il-4 and/or il 13 expression or activity
US20200087680A1 (en) * 2018-09-13 2020-03-19 Nantbio, Inc. Conditional Living Sensors
WO2020146390A1 (en) * 2019-01-09 2020-07-16 Exocure Biosciences, Inc. Bacteria-derived vesicles and uses thereof
JOP20210186A1 (en) 2019-01-10 2023-01-30 Janssen Biotech Inc Prostate neoantigens and their uses
US12044687B1 (en) 2019-03-20 2024-07-23 Nantbio, Inc. Method of detecting cellular reporting for therapy production
EP3972992A4 (en) 2019-05-20 2023-07-19 Pandion Operations, Inc. Madcam targeted immunotolerance
US20220332780A1 (en) 2019-09-10 2022-10-20 Obsidian Therapeutics, Inc. Ca2-il15 fusion proteins for tunable regulation
WO2021091541A1 (en) * 2019-11-05 2021-05-14 Kri Technologies Incorporated Identifying cancer neoantigens for personalized cancer immunotherapy
US12018289B2 (en) 2019-11-18 2024-06-25 Janssen Biotech, Inc. Vaccines based on mutant CALR and JAK2 and their uses
US11981715B2 (en) 2020-02-21 2024-05-14 Pandion Operations, Inc. Tissue targeted immunotolerance with a CD39 effector
CN115379853A (en) * 2020-03-20 2022-11-22 南特细胞公司 T cells responsive to patient neoepitopes
US11920202B2 (en) * 2020-04-09 2024-03-05 University Of Connecticut Unbiased identification of tumor rejection mediating neoepitopes
JP2023546574A (en) * 2020-10-13 2023-11-06 エヌイーシー ラボラトリーズ ヨーロッパ ゲーエムベーハー Multi-instance learning for peptide-MHC presentation prediction
EP4229420A4 (en) * 2020-10-19 2024-10-02 Nantbio Inc Arrayed peptide neoepitope generator
CN113173986B (en) * 2021-03-24 2022-01-07 深圳市新靶向生物科技有限公司 Antigenic peptide related to lung cancer driver gene mutation and application thereof
WO2023196936A1 (en) * 2022-04-06 2023-10-12 Imunon, Inc. Polynucleotide cancer vaccine compositions and methods of using the same
WO2024031027A2 (en) * 2022-08-03 2024-02-08 Gritstone Bio, Inc. Cta vaccine cassettes
WO2024167669A1 (en) * 2023-02-07 2024-08-15 Mayo Foundation For Medical Education And Research Combinations of dendritic cell-based vaccines and checkpoint inhibitors
CN116814642B (en) * 2023-07-17 2024-09-17 南通大学 Biomarker for predicting prognosis of liver cancer patient and application thereof
CN117487914A (en) * 2023-10-27 2024-02-02 广东药科大学 Application of targeting ZC3H18/PD-L1 signal axis in tumor immune escape detection, treatment and prognosis

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US600820A (en) 1898-03-15 Registering voting-machine
US4436727A (en) 1982-05-26 1984-03-13 Ribi Immunochem Research, Inc. Refined detoxified endotoxin product
US4866034A (en) 1982-05-26 1989-09-12 Ribi Immunochem Research Inc. Refined detoxified endotoxin
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4877611A (en) 1986-04-15 1989-10-31 Ribi Immunochem Research Inc. Vaccine containing tumor antigens and adjuvants
US4912094B1 (en) 1988-06-29 1994-02-15 Ribi Immunochem Research Inc. Modified lipopolysaccharides and process of preparation
US5725871A (en) 1989-08-18 1998-03-10 Danbiosyst Uk Limited Drug delivery compositions comprising lysophosphoglycerolipid
US5466468A (en) 1990-04-03 1995-11-14 Ciba-Geigy Corporation Parenterally administrable liposome formulation comprising synthetic lipids
DE69312487T2 (en) 1992-05-18 1997-11-27 Minnesota Mining & Mfg DEVICE FOR TRANSMUCOSAL DELIVERY OF ACTIVE SUBSTANCES
EP1167377B2 (en) 1994-07-15 2012-08-08 University of Iowa Research Foundation Immunomodulatory oligonucleotides
CO4600681A1 (en) * 1996-02-24 1998-05-08 Boehringer Ingelheim Pharma PHARMACEUTICAL COMPOSITION FOR IMMUNITY MODULATION
US5856462A (en) 1996-09-10 1999-01-05 Hybridon Incorporated Oligonucleotides having modified CpG dinucleosides
US5994132A (en) 1996-10-23 1999-11-30 University Of Michigan Adenovirus vectors
US20060269532A1 (en) * 1997-02-25 2006-11-30 Corixa Corporation Compositions and methods for the therapy and diagnosis of prostate cancer
GB9727262D0 (en) 1997-12-24 1998-02-25 Smithkline Beecham Biolog Vaccine
US20030072767A1 (en) * 1998-09-30 2003-04-17 Alexander Gaiger Compositions and methods for WT1 specific immunotherapy
ATE361988T1 (en) * 1998-12-09 2007-06-15 Us Gov Health & Human Serv RECOMBINANT VECTOR EXPRESSING AND USING MULTIPLE CO-STIMULATORY MOLECULES
US7009042B1 (en) * 1999-10-07 2006-03-07 Corixa Corporation Methods of using a Mycobacterium tuberculosis coding sequence to facilitate stable and high yield expression of the heterologous proteins
WO2002000174A2 (en) * 2000-06-28 2002-01-03 Corixa Corporation Compositions and methods for the therapy and diagnosis of lung cancer
AU2002303135A1 (en) * 2001-03-13 2002-09-24 Corixa Corporation Heterologous fusion protein constructs comprising a leishmania antigen
WO2002083070A2 (en) * 2001-04-10 2002-10-24 Corixa Corporation Compounds for immunotherapy and diagnosis of colon cancer and methods for their use
JP2006506072A (en) * 2002-11-12 2006-02-23 デイッセロース，アルバート，ビー Adenovirus vector vaccine
US20040202648A1 (en) * 2003-04-04 2004-10-14 Cabezon Teresa Elisa Virgina Silva Vaccines
WO2008012237A1 (en) * 2006-07-24 2008-01-31 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa Multi-antigen construct and uses thereof
ES2725450T3 (en) 2007-07-02 2019-09-24 Etubics Corp Methods and compositions for the production of an adenoviral vector for use in multiple vaccinations
DK2714071T3 (en) * 2011-05-24 2019-09-16 Biontech Rna Pharmaceuticals Gmbh INDIVIDUALIZED VACCINES AGAINST CANCER
US9605276B2 (en) * 2012-08-24 2017-03-28 Etubics Corporation Replication defective adenovirus vector in vaccination
GB201321384D0 (en) * 2013-12-04 2014-01-15 Isis Innovation Molecular adjuvant
AU2015284248B2 (en) 2014-06-30 2020-04-16 Altor Bioscience Corporation IL-15-based molecules and methods of use thereof
EP3413909A4 (en) * 2016-02-11 2019-10-30 Nant Holdings IP, LLC Subcutaneous delivery of adenovirus with dual targeting

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