SG11201810631SA - Compositions and methods for tumor vaccination using prostate cancer-associated antigens - Google Patents

Compositions and methods for tumor vaccination using prostate cancer-associated antigens

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Publication number
SG11201810631SA
SG11201810631SA SG11201810631SA SG11201810631SA SG11201810631SA SG 11201810631S A SG11201810631S A SG 11201810631SA SG 11201810631S A SG11201810631S A SG 11201810631SA SG 11201810631S A SG11201810631S A SG 11201810631SA SG 11201810631S A SG11201810631S A SG 11201810631SA
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SG
Singapore
Prior art keywords
seattle
suite
international
methods
prostate cancer
Prior art date
Application number
SG11201810631SA
Inventor
Frank Jones
Joseph Balint
Yvette Latchman
Adrian Rice
Elizabeth Gabitzsch
Original Assignee
Etubics Corp
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Publication date
Application filed by Etubics Corp filed Critical Etubics Corp
Publication of SG11201810631SA publication Critical patent/SG11201810631SA/en

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    • C12N2710/10362—Methods of inactivation or attenuation by genetic engineering

Abstract

TripleGene Insert for Prostate Cancer Vaccine Prostate Stern Cell Antigen (PSCA) PA PSA T2A Prostate Specific Membrane Antigen (PSMA) 2A sequence with Gly-Ser-Gly linker from Porcine teschovirus-1 2A sequence with Gly-Ser-Gly linker from Thosea asigna virus (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 07 December 2017 (07.12.2017) WIP0 I PCT IiiimmoimiolollmolommioloiollmoiliniovoimIE (10) International Publication Number WO 2017/210562 Al (51) International Patent Classification: A61K 39/39 (2006.01) A61N 5/10 (2006.01) A61K 39/395 (2006.01) Cl 2N 15/86 (2006.01) A61K 45/06 (2006.01) (21) International Application Number: PCT/US2017/035694 (22) International Filing Date: 02 June 2017 (02.06.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/345,582 03 June 2016 (03.06.2016) US (71) Applicant: ETUBICS CORPORATION [US/US]; 410 West Harrison Street, Suite 200, Seattle, WA 98119 (US). (72) Inventors: JONES, Frank, R.; 410 West Harrison Street, Suite 200, Seattle, WA 98119 (US). BALINT, Joseph; 410 West Harrison Street, Suite 200, Seattle, WA 98119 (US). LATCHMAN, Yvette; 410 West Harrison Street, Suite 200, Seattle, WA 98119 (US). RICE, Adrian; 410 West Harrison Street, Suite 200, Seattle, WA 98119 (US). GABITZSCH, Elizabeth; 410 West Harrison Street, Suite 200, Seattle, WA 98119 (US). (74) Agent: RAMANATHAN, Renuka et al.; Wilson Sonsini Goodrich & Rosati, 650 Page Mill Road, Palo Alto, CA 94304-1050 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). (54) Title: COMPOSITIONS AND METHODS FOR TUMOR VACCINATION USING PROSTATE CANCER-ASSOCIATED AN- TIGENS Possible Prostate Cancer Multi-Antigen Gene Construct for Insertion into Ad5 LE1-, E2b-] FIG. 10A (57) : Methods and compositions for constructing and producing recombinant adenovirus- based vector vaccines are provid- ed. In particular aspects, there are be provided compositions and methods involving adenovirus vectors comprising genes for target antigens, such as pro state-specific antigen (PSA), pro state- specific membrane antigen (PSMA), MUC1, CEA, and/or Brachyury, and costimulatory molecules for use in treatment methods that generate highly reactive anti-tumor immune responses and that allows for multiple vaccinations in individuals with preexisting immunity to adenovirus. [Continued on next page] WO 2017/210562 Al MIDEDIMOM010101110101110010i0101REIEDIDIIMOVOIS Published: with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) with sequence listing part of description (Rule 5.2(a))
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