BR112012008084A2 - método terapêuticos e composições. - Google Patents

método terapêuticos e composições.

Info

Publication number
BR112012008084A2
BR112012008084A2 BR112012008084A BR112012008084A BR112012008084A2 BR 112012008084 A2 BR112012008084 A2 BR 112012008084A2 BR 112012008084 A BR112012008084 A BR 112012008084A BR 112012008084 A BR112012008084 A BR 112012008084A BR 112012008084 A2 BR112012008084 A2 BR 112012008084A2
Authority
BR
Brazil
Prior art keywords
reducing
tumor
compositions
methods
lox12
Prior art date
Application number
BR112012008084A
Other languages
English (en)
Inventor
Van Vlasselaer Peter
Smith Victoria
Original Assignee
Gilead Biologics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Biologics Inc filed Critical Gilead Biologics Inc
Publication of BR112012008084A2 publication Critical patent/BR112012008084A2/pt

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering N.A.
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed
    • C12N2310/531—Stem-loop; Hairpin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

patente de invenção: métodos terapêuticos e composições. a presente invenção refere-se a métodos para modular o ambiente de um tumor, inibindo a atividade da enzima extracelular lisil oxidaselike 2 (loxl2). os métodos revelados neste pedido são eficazes na redução de crescimento tumoral, redução do recrutamento de células para o tumor, redução de ativação de fibroblasto, redução de desmoplasia, redução de vasculogênese, redução do número de tafs, redução da produção de fator de crescimento, inibição da deposição de colágeno, e aumento da necrose e picnose no tumor. inibidores exemplares da atividade de loxl2 são anticorpos e sirnas.
BR112012008084A 2009-08-21 2010-08-20 método terapêuticos e composições. BR112012008084A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23585209P 2009-08-21 2009-08-21
PCT/US2010/046248 WO2011022710A1 (en) 2009-08-21 2010-08-20 Therapeutic methods and compositions

Publications (1)

Publication Number Publication Date
BR112012008084A2 true BR112012008084A2 (pt) 2019-09-24

Family

ID=43607358

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112012008084A BR112012008084A2 (pt) 2009-08-21 2010-08-20 método terapêuticos e composições.

Country Status (12)

Country Link
US (1) US20110076272A1 (pt)
EP (1) EP2467162A4 (pt)
JP (1) JP2013502437A (pt)
KR (1) KR20120054076A (pt)
CN (1) CN102711821A (pt)
AU (1) AU2010284001A1 (pt)
BR (1) BR112012008084A2 (pt)
CA (1) CA2771630A1 (pt)
IL (1) IL218212A0 (pt)
MX (1) MX2012002271A (pt)
RU (1) RU2012110587A (pt)
WO (1) WO2011022710A1 (pt)

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SG2014004816A (en) * 2009-08-21 2014-03-28 Gilead Biologics Inc Catalytic domains from lysyl oxidase and loxl2
BR112012008080A2 (pt) * 2009-08-21 2017-07-04 Gilead Biologics Inc ensaios de rastreamento in vivo.
US20110044907A1 (en) * 2009-08-21 2011-02-24 Derek Marshall In vivo screening assays
EP2482814A4 (en) * 2009-09-29 2013-04-03 Gilead Biologics Inc METHOD AND COMPOSITIONS FOR TREATING OKULAR FIBROSIS
CA2789022A1 (en) * 2010-02-04 2011-08-11 Gilead Biologics, Inc. Antibodies that bind to lysyl oxidase-like 2 (loxl2) and methods of use therefor
US20140186340A1 (en) * 2011-04-08 2014-07-03 Gilead Biologics, Inc. Methods and Compositions for Normalization of Tumor Vasculature by Inhibition of LOXL2
EP3348576A1 (en) * 2012-10-30 2018-07-18 Gilead Sciences, Inc. Therapeutic and diagnostic methods related to lysyl oxidase-like 2 (loxl2)
CA2977947A1 (en) 2015-03-06 2016-09-15 Pharmakea, Inc. Fluorinated lysyl oxidase-like 2 inhibitors and uses thereof
CN106337037A (zh) * 2015-07-08 2017-01-18 中国科学院上海生命科学研究院 一种诱导成纤维细胞直接向神经细胞转化的药物组合物及其用途
BR112019004517A2 (pt) 2016-09-07 2019-08-13 Pharmakea Inc formas cristalinas de um inibidor lisil-oxidase-semelhante 2 e métodos de preparação
EP4052707A1 (en) * 2016-09-07 2022-09-07 Pharmakea, Inc. Uses of a lysyl oxidase-like 2 inhibitor
GB201809295D0 (en) 2018-06-06 2018-07-25 Institute Of Cancer Res Royal Cancer Hospital Lox inhibitors
GB201818750D0 (en) 2018-11-16 2019-01-02 Institute Of Cancer Res Royal Cancer Hospital Lox inhibitors
GB202209622D0 (en) 2022-06-30 2022-08-17 Institute Of Cancer Res Royal Cancer Hospital Compounds
GB202209624D0 (en) 2022-06-30 2022-08-17 Institute Of Cancer Res Royal Cancer Hospital Prodrugs

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Also Published As

Publication number Publication date
JP2013502437A (ja) 2013-01-24
IL218212A0 (en) 2012-04-30
KR20120054076A (ko) 2012-05-29
CA2771630A1 (en) 2011-02-24
MX2012002271A (es) 2012-07-20
EP2467162A1 (en) 2012-06-27
AU2010284001A1 (en) 2012-03-22
CN102711821A (zh) 2012-10-03
RU2012110587A (ru) 2013-09-27
WO2011022710A1 (en) 2011-02-24
US20110076272A1 (en) 2011-03-31
EP2467162A4 (en) 2013-10-02

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