MX2007015931A - Receptores de sabor dulce-umami y umami-dulce humanos quimericos. - Google Patents

Receptores de sabor dulce-umami y umami-dulce humanos quimericos.

Info

Publication number
MX2007015931A
MX2007015931A MX2007015931A MX2007015931A MX2007015931A MX 2007015931 A MX2007015931 A MX 2007015931A MX 2007015931 A MX2007015931 A MX 2007015931A MX 2007015931 A MX2007015931 A MX 2007015931A MX 2007015931 A MX2007015931 A MX 2007015931A
Authority
MX
Mexico
Prior art keywords
umami
sweet
taste receptors
chimeric human
receptors
Prior art date
Application number
MX2007015931A
Other languages
English (en)
Inventor
Xiaodong Li
Feng Zhang
Hong Xu
Qing Li
Original Assignee
Senomyx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Senomyx Inc filed Critical Senomyx Inc
Publication of MX2007015931A publication Critical patent/MX2007015931A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2503/00—Use of cells in diagnostics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Esta invencion se relaciona a receptores de sabor quimericos que comprenden la porcion extracelular de un T1R o una variante o fragmento del mismo, ya sea T1R1 o T1R2, y la porcion de transmembrana de otro T1R o una variante de fragmento del mismo, ya sea T1R1 o T1R2, preferiblemente asociado con un polipeptido T1R3 y una proteina G adecuada. Estos receptores de sabor quimericos y celulas que expresan tales receptores de sabor quimerico son utiles en los ensayos para identificar ligandos dulces y umami tambien en ensayos para identificar aumentadores dulces y umami. Adicionalmente estos receptores de sabor quimericos y celulas que expresan los mismos se pueden utilizar para mapear y determinar donde los ligandos dulces y umami especificos interactuan con sus receptores respectivos y para elucidar el mecanismo de activacion de receptor.
MX2007015931A 2005-10-20 2006-10-19 Receptores de sabor dulce-umami y umami-dulce humanos quimericos. MX2007015931A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US72832405P 2005-10-20 2005-10-20
PCT/US2006/041158 WO2007047988A2 (en) 2005-10-20 2006-10-19 Chimeric human sweet-umami and umami-sweet taste receptors

Publications (1)

Publication Number Publication Date
MX2007015931A true MX2007015931A (es) 2008-04-22

Family

ID=37963349

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2007015931A MX2007015931A (es) 2005-10-20 2006-10-19 Receptores de sabor dulce-umami y umami-dulce humanos quimericos.

Country Status (11)

Country Link
EP (2) EP1937718B1 (es)
JP (1) JP5342878B2 (es)
CN (1) CN101605810B (es)
AU (1) AU2006304797B2 (es)
CA (2) CA2611349C (es)
ES (1) ES2658859T3 (es)
HK (1) HK1247942A1 (es)
IL (1) IL187828A0 (es)
MX (1) MX2007015931A (es)
NO (1) NO20076258L (es)
WO (1) WO2007047988A2 (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080305500A1 (en) * 2007-06-08 2008-12-11 Senomyx, Inc. Novel cell-based assays for identifying enhancers or inhibitors of t1r taste receptors (t1r2/t1r3 sweet) and umami (t1r1/t1r3 umami) taste receptors
US7928111B2 (en) 2007-06-08 2011-04-19 Senomyx, Inc. Compounds including substituted thienopyrimidinone derivatives as ligands for modulating chemosensory receptors
US8633186B2 (en) 2007-06-08 2014-01-21 Senomyx Inc. Modulation of chemosensory receptors and ligands associated therewith
US9603848B2 (en) 2007-06-08 2017-03-28 Senomyx, Inc. Modulation of chemosensory receptors and ligands associated therewith
WO2010014813A2 (en) 2008-07-31 2010-02-04 Senomyx, Inc. Compositions comrpising sweetness enhancers and methods of making them
CA2731800C (en) 2008-07-31 2018-03-20 Senomyx, Inc. Processes and intermediates for making sweet taste enhancers
EP2391711B1 (en) * 2009-02-02 2015-04-08 Chromocell Corporation Novel cell lines and methods
JP5905187B2 (ja) 2009-12-02 2016-04-20 国立大学法人 東京大学 甘味受容体発現コンストラクト、これを発現させた細胞体、及びその利用
US9000054B2 (en) 2010-08-12 2015-04-07 Senomyx, Inc. Method of improving stability of sweet enhancer and composition containing stabilized sweet enhancer
MX354835B (es) 2012-08-06 2018-03-21 Senomyx Inc Modificador del sabor dulce.
JO3155B1 (ar) 2013-02-19 2017-09-20 Senomyx Inc معدِّل نكهة حلوة
RU2665812C2 (ru) 2013-05-10 2018-09-04 Пепсико, Инк. Метод анализа интернализации вкусовых рецепторов
EP2994477A4 (en) * 2013-05-10 2017-03-22 Pepsico, Inc. Cells as a model to identify potential taste modulators
CN106998743B (zh) * 2014-12-10 2024-05-24 马斯公司 调节脂肪酸受体活性的化合物及包含该化合物的宠物食品
CN108611324A (zh) * 2018-05-07 2018-10-02 云南中烟工业有限责任公司 一种稳定共表达重组人源甜味受体蛋白的真核细胞系及其制备方法
MX2021001193A (es) 2018-08-07 2021-04-28 Firmenich Incorporated 2,2-dioxidos de 4-amino-1h-benzo[c][1,2,6]tiadiazina 5-sustituidos y formulaciones y usos de los mismos.
WO2023154597A1 (en) * 2022-02-11 2023-08-17 Firmenich Incorporated Cells expressing umami taste receptors and uses thereof

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5825980B2 (ja) 1976-02-12 1983-05-31 ヤマサ醤油株式会社 サイクリックヌクレオチドの定量法
US4458066A (en) 1980-02-29 1984-07-03 University Patents, Inc. Process for preparing polynucleotides
US5506337A (en) 1985-03-15 1996-04-09 Antivirals Inc. Morpholino-subunit combinatorial library and method
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US5010175A (en) 1988-05-02 1991-04-23 The Regents Of The University Of California General method for producing and selecting peptides with specific properties
US5464764A (en) 1989-08-22 1995-11-07 University Of Utah Research Foundation Positive-negative selection methods and vectors
EP0779362B2 (en) 1989-12-22 2012-06-13 Laboratoires Serono SA DNA constructs for endogenous gene activation and expression modification
US5272071A (en) 1989-12-22 1993-12-21 Applied Research Systems Ars Holding N.V. Method for the modification of the expression characteristics of an endogenous gene of a given cell line
JPH04505546A (ja) 1990-02-09 1992-09-24 アスラブ　ソシエテ　アノニム 写真平版マイクロ製造法を用いて製造した放射場静電マイクロモーター及び前記マイクロモーターの製造方法
IE66205B1 (en) 1990-06-14 1995-12-13 Paul A Bartlett Polypeptide analogs
US5650489A (en) 1990-07-02 1997-07-22 The Arizona Board Of Regents Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof
US5401629A (en) 1990-08-07 1995-03-28 The Salk Institute Biotechnology/Industrial Associates, Inc. Assay methods and compositions useful for measuring the transduction of an intracellular signal
NZ245015A (en) 1991-11-05 1995-12-21 Transkaryotic Therapies Inc Delivery of human growth hormone through the administration of transfected cell lines encoding human growth hormone, which are physically protected from host immune response; the transfected cells and their production
US6270989B1 (en) 1991-11-05 2001-08-07 Transkaryotic Therapies, Inc. Protein production and delivery
US5641670A (en) 1991-11-05 1997-06-24 Transkaryotic Therapies, Inc. Protein production and protein delivery
US5573905A (en) 1992-03-30 1996-11-12 The Scripps Research Institute Encoded combinatorial chemical libraries
US5288514A (en) 1992-09-14 1994-02-22 The Regents Of The University Of California Solid phase and combinatorial synthesis of benzodiazepine compounds on a solid support
US6664107B1 (en) 1993-05-26 2003-12-16 Ontario Cancer Institute, University Health Network CD45 disrupted nucleic acid
US5426039A (en) 1993-09-08 1995-06-20 Bio-Rad Laboratories, Inc. Direct molecular cloning of primer extended DNA containing an alkane diol
US5519134A (en) 1994-01-11 1996-05-21 Isis Pharmaceuticals, Inc. Pyrrolidine-containing monomers and oligomers
US5593853A (en) 1994-02-09 1997-01-14 Martek Corporation Generation and screening of synthetic drug libraries
US5539083A (en) 1994-02-23 1996-07-23 Isis Pharmaceuticals, Inc. Peptide nucleic acid combinatorial libraries and improved methods of synthesis
US5525735A (en) 1994-06-22 1996-06-11 Affymax Technologies Nv Methods for synthesizing diverse collections of pyrrolidine compounds
US5549974A (en) 1994-06-23 1996-08-27 Affymax Technologies Nv Methods for the solid phase synthesis of thiazolidinones, metathiazanones, and derivatives thereof
US6383778B1 (en) 1998-07-28 2002-05-07 The Regents Of The University Of California Nucleic acids encoding a G-protein coupled receptor involved in sensory transduction
US7368285B2 (en) * 2001-03-07 2008-05-06 Senomyx, Inc. Heteromeric umami T1R1/T1R3 taste receptors and isolated cells that express same
CN101891821A (zh) * 2001-06-26 2010-11-24 塞诺米克斯公司 T1r异源寡聚的味觉受体和表达所述受体的细胞系及其在鉴定味觉化合物中的用途
AU2002326315B2 (en) * 2001-06-26 2007-07-05 Senomyx, Inc. T1R hetero-oligomeric taste receptors and cell lines that express said receptors and use thereof for identification of taste compounds
BRPI0413347A (pt) * 2003-08-06 2006-10-10 Senomyx Inc novos sabores, modificadores de sabor, agentes de sabor, realçadores de sabor, agentes de sabor e/ou realçadores umami ou doces, e utilização correspondente
TWI552751B (zh) 2011-06-20 2016-10-11 Ｈ 朗德貝克公司 投予４－（（１ｒ，３ｓ）－６－氯－３－苯基－二氫茚－１－基）－１，２，２－三甲基－哌及其鹽用於治療精神分裂症的方法

Also Published As

Publication number Publication date
ES2658859T3 (es) 2018-03-12
NO20076258L (no) 2008-05-15
HK1247942A1 (zh) 2018-10-05
CN101605810B (zh) 2013-07-17
AU2006304797A1 (en) 2007-04-26
JP5342878B2 (ja) 2013-11-13
EP3312194A1 (en) 2018-04-25
CA2611349C (en) 2017-01-03
IL187828A0 (en) 2008-03-20
EP1937718B1 (en) 2017-12-06
EP1937718A2 (en) 2008-07-02
JP2009517003A (ja) 2009-04-30
WO2007047988A3 (en) 2009-04-23
CA2611349A1 (en) 2007-04-26
CA2952660A1 (en) 2007-04-26
AU2006304797B2 (en) 2013-01-31
CA2952660C (en) 2018-09-11
EP1937718A4 (en) 2009-11-11
WO2007047988A2 (en) 2007-04-26
CN101605810A (zh) 2009-12-16

Similar Documents

Publication Publication Date Title
MX2007015931A (es) Receptores de sabor dulce-umami y umami-dulce humanos quimericos.
EP2535351A3 (en) Dual specificity antibody fusions
MX2007008017A (es) Polipeptidos que se ligan a br3 y usos de los mismos.
CU20120095A7 (es) Antagonistas de pcsk9
MX2020001227A (es) Composiciones y metodos para detectar y cuantificar la proteina en la celula hospedera en las lineas de celulas y productos de polipeptidos recombinantes.
MX2017007136A (es) Identificacion de vsig8 como el receptor vista putativo y su uso para producir moduladores vista/vsig8.
WO2009091826A3 (en) Compositions and methods related to a human cd19-specific chimeric antigen receptor (h-car)
ITMI20040598A1 (it) Metodo per la rilevazione di parametri intracellulari con sonde proteiche luminescenti per lo screening di molecole in grado di alterare detti parametri
ATE393778T1 (de) Chimäre alpha q-gustducin g-proteine
TR201905437T4 (tr) İki işlevli polipeptidler.
MX2012009175A (es) Metodos para identificar y aislar celulas que expresan un polipeptido.
WO2006002161A3 (en) Modulators of odorant receptors
DK1864131T3 (da) Naturlig ligand af G protein koblet receptor RCC356 og anvendelser deraf
PE20081756A1 (es) Metodos y dispositivos para el diagnostico de apendicitis
WO2011069156A3 (en) Compositions and methods for enhancing odorant receptor activity
SG11202111980QA (en) Screening methods and assays for use with transmembrane proteins, in particular with gpcrs
ATE519784T1 (de) An den humanen igg-fc-rezeptor iib (fcgammariib) bindende substanz
HK1117595A1 (en) Method for detecting autoimmune antibodies against tsh receptors and novel tsh-receptor chimaeras
WO2010009856A3 (en) Goodpasture antigen binding protein and its detection
PL2121758T3 (pl) Ludzkie przeciwciała monoklonalne przeciwko receptorowi tyreotropiny, które działają jako antagoniści
NZ605640A (en) Signal biomarkers
WO2010040003A3 (en) Human a2a adenosine receptor crystals and uses thereof
GB0611708D0 (en) Novel antibodies against prion protein and uses thereof
WO2012141792A3 (en) Adiponectin receptor c-terminal fragments (ctf)-immunoglobulin
WO2010022924A8 (en) Antibodies against human epo receptor

Legal Events

Date Code Title Description
FA Abandonment or withdrawal