NO20076258L - Kimaer human sot-umami og umami-sot smaksreseptorer - Google Patents

Kimaer human sot-umami og umami-sot smaksreseptorer

Info

Publication number
NO20076258L
NO20076258L NO20076258A NO20076258A NO20076258L NO 20076258 L NO20076258 L NO 20076258L NO 20076258 A NO20076258 A NO 20076258A NO 20076258 A NO20076258 A NO 20076258A NO 20076258 L NO20076258 L NO 20076258L
Authority
NO
Norway
Prior art keywords
umami
soot
taste receptors
receptors
chimeric taste
Prior art date
Application number
NO20076258A
Other languages
English (en)
Inventor
Hong Xu
Xiaodong Li
Feng Zhang
Qing Li
Original Assignee
Senomyx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Senomyx Inc filed Critical Senomyx Inc
Publication of NO20076258L publication Critical patent/NO20076258L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2503/00—Use of cells in diagnostics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Foreliggende oppfinnelse angår kimære smaksreseptorer omfattende den ekstracellulære del av én TlR eller en variant eller fragment derav, enten TlRl eller T1R2 og transmembran- delen av en annen TlR eller en variant eller fragment derav, enten TlRl eller T1R2, fortrinnsvis assosiert med et T1R3 polypeptid og et egnet G-protein. Disse kimære smaksreseptorer og celler som uttrykker slike kimære smaksreseptorer er anvendelige i forsøk for å identifisere søt- og umami-ligander så vel som i forsøk for å identifisere søt- og umami-enhancere. I tillegg kan disse kimære smaksreseptorer og celler som uttrykker disse anvendes for å kartlegge og bestemme hvor spesifikke søt- og umami-ligander interagerer med deres respektive reseptorer og belyse mekanismen av reseptor-aktivering.
NO20076258A 2005-10-20 2007-12-05 Kimaer human sot-umami og umami-sot smaksreseptorer NO20076258L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US72832405P 2005-10-20 2005-10-20
PCT/US2006/041158 WO2007047988A2 (en) 2005-10-20 2006-10-19 Chimeric human sweet-umami and umami-sweet taste receptors

Publications (1)

Publication Number Publication Date
NO20076258L true NO20076258L (no) 2008-05-15

Family

ID=37963349

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20076258A NO20076258L (no) 2005-10-20 2007-12-05 Kimaer human sot-umami og umami-sot smaksreseptorer

Country Status (11)

Country Link
EP (2) EP3312194A1 (no)
JP (1) JP5342878B2 (no)
CN (1) CN101605810B (no)
AU (1) AU2006304797B2 (no)
CA (2) CA2611349C (no)
ES (1) ES2658859T3 (no)
HK (1) HK1247942A1 (no)
IL (1) IL187828A0 (no)
MX (1) MX2007015931A (no)
NO (1) NO20076258L (no)
WO (1) WO2007047988A2 (no)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8633186B2 (en) 2007-06-08 2014-01-21 Senomyx Inc. Modulation of chemosensory receptors and ligands associated therewith
US7928111B2 (en) * 2007-06-08 2011-04-19 Senomyx, Inc. Compounds including substituted thienopyrimidinone derivatives as ligands for modulating chemosensory receptors
US20080305500A1 (en) * 2007-06-08 2008-12-11 Senomyx, Inc. Novel cell-based assays for identifying enhancers or inhibitors of t1r taste receptors (t1r2/t1r3 sweet) and umami (t1r1/t1r3 umami) taste receptors
US9603848B2 (en) 2007-06-08 2017-03-28 Senomyx, Inc. Modulation of chemosensory receptors and ligands associated therewith
ES2647947T3 (es) 2008-07-31 2017-12-27 Senomyx, Inc. Procesos y productos intermedios para la preparación de potenciadores del sabor dulce
EP2328426B1 (en) 2008-07-31 2014-10-01 Senomyx, Inc. Compositions comrpising sweetness enhancers and methods of making them
KR101751074B1 (ko) * 2009-02-02 2017-06-26 크로모셀 코포레이션 신규한 세포주와 방법
JP5905187B2 (ja) 2009-12-02 2016-04-20 国立大学法人 東京大学 甘味受容体発現コンストラクト、これを発現させた細胞体、及びその利用
CN106107406B (zh) 2010-08-12 2020-06-09 弗门尼舍公司 提高甜味增强剂的稳定性的方法和包含稳定的甜味增强剂的组合物
EP3593648B1 (en) 2012-08-06 2021-07-14 Firmenich Incorporated Sweet flavor modifier
JO3155B1 (ar) 2013-02-19 2017-09-20 Senomyx Inc معدِّل نكهة حلوة
US10107794B2 (en) 2013-05-10 2018-10-23 Pepsico, Inc. Methods of using U2-OS cells to identify potential sweet taste modulators
US9766236B2 (en) 2013-05-10 2017-09-19 Pepsico, Inc. Taste receptor internalization assay
EP3229610B1 (en) * 2014-12-10 2021-06-09 Mars, Incorporated Flavor compositions and pet food products containing the same
CN108611324A (zh) * 2018-05-07 2018-10-02 云南中烟工业有限责任公司 一种稳定共表达重组人源甜味受体蛋白的真核细胞系及其制备方法
MX2021001193A (es) 2018-08-07 2021-04-28 Firmenich Incorporated 2,2-dioxidos de 4-amino-1h-benzo[c][1,2,6]tiadiazina 5-sustituidos y formulaciones y usos de los mismos.
WO2023154597A1 (en) * 2022-02-11 2023-08-17 Firmenich Incorporated Cells expressing umami taste receptors and uses thereof

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5825980B2 (ja) 1976-02-12 1983-05-31 ヤマサ醤油株式会社 サイクリックヌクレオチドの定量法
US4458066A (en) 1980-02-29 1984-07-03 University Patents, Inc. Process for preparing polynucleotides
US5506337A (en) 1985-03-15 1996-04-09 Antivirals Inc. Morpholino-subunit combinatorial library and method
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US5010175A (en) 1988-05-02 1991-04-23 The Regents Of The University Of California General method for producing and selecting peptides with specific properties
US5464764A (en) 1989-08-22 1995-11-07 University Of Utah Research Foundation Positive-negative selection methods and vectors
DE69031172T2 (de) 1989-12-22 1998-03-12 Applied Research Systems Modifikation der endogenen genexpression mit hilfe eines regulatorischen elements mittels homologe rekombination
US5272071A (en) 1989-12-22 1993-12-21 Applied Research Systems Ars Holding N.V. Method for the modification of the expression characteristics of an endogenous gene of a given cell line
JPH04505546A (ja) 1990-02-09 1992-09-24 アスラブ　ソシエテ　アノニム 写真平版マイクロ製造法を用いて製造した放射場静電マイクロモーター及び前記マイクロモーターの製造方法
IE66205B1 (en) 1990-06-14 1995-12-13 Paul A Bartlett Polypeptide analogs
US5650489A (en) 1990-07-02 1997-07-22 The Arizona Board Of Regents Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof
US5401629A (en) 1990-08-07 1995-03-28 The Salk Institute Biotechnology/Industrial Associates, Inc. Assay methods and compositions useful for measuring the transduction of an intracellular signal
US6270989B1 (en) 1991-11-05 2001-08-07 Transkaryotic Therapies, Inc. Protein production and delivery
PT101031B (pt) 1991-11-05 2002-07-31 Transkaryotic Therapies Inc Processo para o fornecimento de proteinas por terapia genetica
US5641670A (en) 1991-11-05 1997-06-24 Transkaryotic Therapies, Inc. Protein production and protein delivery
US5573905A (en) 1992-03-30 1996-11-12 The Scripps Research Institute Encoded combinatorial chemical libraries
US5288514A (en) 1992-09-14 1994-02-22 The Regents Of The University Of California Solid phase and combinatorial synthesis of benzodiazepine compounds on a solid support
US6664107B1 (en) 1993-05-26 2003-12-16 Ontario Cancer Institute, University Health Network CD45 disrupted nucleic acid
US5426039A (en) 1993-09-08 1995-06-20 Bio-Rad Laboratories, Inc. Direct molecular cloning of primer extended DNA containing an alkane diol
US5519134A (en) 1994-01-11 1996-05-21 Isis Pharmaceuticals, Inc. Pyrrolidine-containing monomers and oligomers
US5593853A (en) 1994-02-09 1997-01-14 Martek Corporation Generation and screening of synthetic drug libraries
US5539083A (en) 1994-02-23 1996-07-23 Isis Pharmaceuticals, Inc. Peptide nucleic acid combinatorial libraries and improved methods of synthesis
US5525735A (en) 1994-06-22 1996-06-11 Affymax Technologies Nv Methods for synthesizing diverse collections of pyrrolidine compounds
US5549974A (en) 1994-06-23 1996-08-27 Affymax Technologies Nv Methods for the solid phase synthesis of thiazolidinones, metathiazanones, and derivatives thereof
ATE474852T1 (de) 1998-07-28 2010-08-15 Univ California Nukleinsäuren, die für einen an ein g-protein gekoppelten, an der sensorischen transduktion beteiligten rezeptor kodieren
US7368285B2 (en) * 2001-03-07 2008-05-06 Senomyx, Inc. Heteromeric umami T1R1/T1R3 taste receptors and isolated cells that express same
EP2003451B1 (en) * 2001-06-26 2012-05-30 Senomyx, Inc. T1r1-t1r3 hetero-oligomeric umami taste receptors and cell lines that express said receptors and use thereof for identification of umami taste compounds
CN108329393A (zh) * 2001-06-26 2018-07-27 塞诺米克斯公司 T1r异源寡聚的味觉受体和表达所述受体的细胞系及其在鉴定味觉化合物中的用途
CA2900181C (en) * 2003-08-06 2019-01-29 Catherine Tachdjian Novel flavors, flavor modifiers, tastants, taste enhancers, umami or sweet tastants, and/or enhancers and use thereof
TWI552751B (zh) 2011-06-20 2016-10-11 Ｈ 朗德貝克公司 投予４－（（１ｒ，３ｓ）－６－氯－３－苯基－二氫茚－１－基）－１，２，２－三甲基－哌及其鹽用於治療精神分裂症的方法

Also Published As

Publication number Publication date
EP1937718A2 (en) 2008-07-02
CA2952660A1 (en) 2007-04-26
EP1937718A4 (en) 2009-11-11
WO2007047988A2 (en) 2007-04-26
CA2952660C (en) 2018-09-11
HK1247942A1 (zh) 2018-10-05
CA2611349A1 (en) 2007-04-26
MX2007015931A (es) 2008-04-22
IL187828A0 (en) 2008-03-20
JP5342878B2 (ja) 2013-11-13
AU2006304797A1 (en) 2007-04-26
JP2009517003A (ja) 2009-04-30
EP1937718B1 (en) 2017-12-06
WO2007047988A3 (en) 2009-04-23
EP3312194A1 (en) 2018-04-25
CN101605810B (zh) 2013-07-17
ES2658859T3 (es) 2018-03-12
CA2611349C (en) 2017-01-03
CN101605810A (zh) 2009-12-16
AU2006304797B2 (en) 2013-01-31

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