ATE282716T1 - Verfahren zur amplifikation von nukleinsäuresequenzen - Google Patents

Verfahren zur amplifikation von nukleinsäuresequenzen

Info

Publication number
ATE282716T1
ATE282716T1 AT96101620T AT96101620T ATE282716T1 AT E282716 T1 ATE282716 T1 AT E282716T1 AT 96101620 T AT96101620 T AT 96101620T AT 96101620 T AT96101620 T AT 96101620T AT E282716 T1 ATE282716 T1 AT E282716T1
Authority
AT
Austria
Prior art keywords
nucleic acid
copies
acid sequences
disclosed
methods
Prior art date
Application number
AT96101620T
Other languages
English (en)
Inventor
Daniel Louis Kacian
Timothy J Fultz
Original Assignee
Gen Probe Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gen Probe Inc filed Critical Gen Probe Inc
Application granted granted Critical
Publication of ATE282716T1 publication Critical patent/ATE282716T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701Specific hybridization probes
    • C12Q1/706Specific hybridization probes for hepatitis
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844Nucleic acid amplification reactions
    • C12Q1/6865Promoter-based amplification, e.g. nucleic acid sequence amplification [NASBA], self-sustained sequence replication [3SR] or transcription-based amplification system [TAS]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • C12Q1/689Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701Specific hybridization probes
    • C12Q1/702Specific hybridization probes for retroviruses
    • C12Q1/703Viruses associated with AIDS
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/156Polymorphic or mutational markers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/158Expression markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • AIDS & HIV (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
AT96101620T 1989-07-11 1990-07-10 Verfahren zur amplifikation von nukleinsäuresequenzen ATE282716T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US37950189A 1989-07-11 1989-07-11

Publications (1)

Publication Number Publication Date
ATE282716T1 true ATE282716T1 (de) 2004-12-15

Family

ID=23497522

Family Applications (2)

Application Number Title Priority Date Filing Date
AT90307503T ATE141956T1 (de) 1989-07-11 1990-07-10 Verfahren zur vervielfältigung von nukleinsäuresequenzen
AT96101620T ATE282716T1 (de) 1989-07-11 1990-07-10 Verfahren zur amplifikation von nukleinsäuresequenzen

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT90307503T ATE141956T1 (de) 1989-07-11 1990-07-10 Verfahren zur vervielfältigung von nukleinsäuresequenzen

Country Status (15)

Country Link
US (1) US5480784A (de)
EP (3) EP0731174B1 (de)
JP (4) JP3241717B2 (de)
KR (1) KR100242252B1 (de)
AT (2) ATE141956T1 (de)
AU (2) AU650622B2 (de)
DE (2) DE69034177T2 (de)
DK (1) DK0408295T3 (de)
ES (1) ES2091225T3 (de)
FI (1) FI911152A0 (de)
GR (1) GR3021704T3 (de)
IE (1) IE902539A1 (de)
NO (1) NO910902D0 (de)
PT (1) PT94662A (de)
WO (1) WO1991001384A1 (de)

Families Citing this family (289)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5817797A (en) * 1988-06-01 1998-10-06 The United States Of America As Represented By The Department Of Health And Human Services Sequencing DNA; a modification of the polymerase chain reaction
US5780219A (en) * 1989-07-11 1998-07-14 Gen-Probe Incorporated Nucleic acid amplification oligonucleotides and probes to human hepatitis B virus
CA2020958C (en) * 1989-07-11 2005-01-11 Daniel L. Kacian Nucleic acid sequence amplification methods
US7009041B1 (en) 1989-07-11 2006-03-07 Gen-Probe Incorporated Oligonucleotides for nucleic acid amplification and for the detection of Mycobacterium tuberculosis
US5766849A (en) * 1989-07-11 1998-06-16 Gen-Probe Incorporated Methods of amplifying nucleic acids using promoter-containing primer sequence
US5856088A (en) * 1989-07-11 1999-01-05 Gen-Probe Incorporated Detection of human immunodeficiency virus type 1
US6589734B1 (en) 1989-07-11 2003-07-08 Gen-Probe Incorporated Detection of HIV
IE913930A1 (en) * 1990-11-13 1992-06-17 Siska Diagnostics Nucleic acid amplification by two-enzyme, self-sustained¹sequence replication
DK0519053T3 (da) * 1990-12-31 1998-07-20 Promega Corp Nucleinsyreamplifikation med DNA-afhængig RNA-polymeraseaktivitet hos RNA-replicaser
DE4106473C2 (de) * 1991-03-01 1994-03-10 Boehringer Mannheim Gmbh Verfahren zur Herstellung in vitro replizierbarer Nukleinsäuren
AU2663292A (en) * 1991-09-10 1993-04-05 Jack D. Love Dna/rna target and signal amplification
DE4213029A1 (de) * 1991-09-26 1993-04-01 Boehringer Mannheim Gmbh Verfahren zur spezifischen vervielfaeltigung von nukleins aeuresequenzen
US6100099A (en) 1994-09-06 2000-08-08 Abbott Laboratories Test strip having a diagonal array of capture spots
JPH07506254A (ja) * 1992-05-06 1995-07-13 ジェン−プローブ・インコーポレイテッド ヒトb型肝炎ウイルスに対する核酸増幅オリゴヌクレオチドおよびプローブ
AU681082B2 (en) * 1992-05-06 1997-08-21 Gen-Probe Incorporated Nucleic acid sequence amplification method, composition and kit
US6093538A (en) * 1992-05-06 2000-07-25 Gen-Probe Incorporated Nucleic acid probes to ureaplasma
AU687352B2 (en) * 1992-06-08 1998-02-26 Gen-Probe Incorporated Preparation of nucleic acid from mononuclear cells
US5612200A (en) * 1992-06-24 1997-03-18 Gen-Probe Incorporated Method and kit for destroying ability of nucleic acid to be amplified
CA2141430C (en) * 1992-08-04 2009-05-12 Sherrol H. Mcdonough Nucleic acid sequence amplification
DE4238699A1 (de) * 1992-11-17 1994-05-19 Boehringer Mannheim Gmbh Einfaches Nukleinsäurevermehrungsverfahren
US5605798A (en) 1993-01-07 1997-02-25 Sequenom, Inc. DNA diagnostic based on mass spectrometry
WO1994023069A1 (en) 1993-03-26 1994-10-13 Gen-Probe Incorporated Detection of human immunodeficiency virus type 1
WO1995003430A1 (en) * 1993-07-23 1995-02-02 Gen-Probe Incorporated Methods for enhancing nucleic acid amplification
FR2708288B1 (fr) 1993-07-26 1995-09-01 Bio Merieux Procédé d'amplification d'acides nucléiques par transcription utilisant le déplacement, réactifs et nécessaire pour la mise en Óoeuvre de ce procédé.
US5459037A (en) * 1993-11-12 1995-10-17 The Scripps Research Institute Method for simultaneous identification of differentially expressed mRNAs and measurement of relative concentrations
EP0682121B1 (de) * 1993-12-01 2002-08-28 Toyo Boseki Kabushiki Kaisha Verfahren zur ampflifizierung und zum nachweis bestimmter nukleinsäuresequenzen mittels thermostabiler enzyme
WO1995025180A1 (en) * 1994-03-16 1995-09-21 Gen-Probe Incorporated Isothermal strand displacement nucleic acid amplification
EP0776376B1 (de) * 1994-07-15 2001-11-21 Akzo Nobel N.V. Verwendung von rna-polymerase zur verbesserung von nukeinsaeure-amplifikationsverfahren
US5514551A (en) * 1994-10-14 1996-05-07 Gen-Probe Incorporated Compositions for the detection of Chlamydia trachomatis
ATE340866T1 (de) * 1994-10-28 2006-10-15 Gen Probe Inc Zusammensetzungen und verfahren für die gleichzeitige detektion und quantifizierung von einer mehrheit spezifischer nuklein säure sequenzen
DE4441602A1 (de) * 1994-11-23 1996-05-30 Boehringer Mannheim Gmbh Verbessertes Transkriptionsverfahren
US5652126A (en) * 1995-06-07 1997-07-29 Gen-Probe Incorporated Use of restriction endonuclease sequences for cleaving phosphorothioate oligonucleotides
US5932450A (en) * 1995-06-07 1999-08-03 Gen-Probe Incorporated Enzymatic synthesis of oligonucleotides using digestible templates
US5916777A (en) * 1995-06-07 1999-06-29 Gen-Probe Incorporated Enzymatic synthesis of oligonucleotides using 3'-ribonucleotide primers
US5739311A (en) * 1995-06-07 1998-04-14 Gen-Probe Incorporated Enzymatic synthesis of phosphorothioate oligonucleotides using restriction endonucleases
AU723678B2 (en) * 1996-03-18 2000-08-31 Molecular Biology Resources, Inc. Target nucleic acid sequence amplification
JP4241929B2 (ja) 1996-05-22 2009-03-18 ジェン―プローブ・インコーポレーテッド Mycobacterium Kansasiiを検出するための組成物および方法
EP0930369B1 (de) 1996-06-28 2005-11-09 Rebio Gen, Inc. Verfahren zum entdecken von telomerase-aktivität
JPH1028585A (ja) * 1996-07-16 1998-02-03 Toyobo Co Ltd 耐熱性リボヌクレアーゼhを用いる核酸増幅法
WO1998005766A1 (fr) 1996-08-02 1998-02-12 Bio Merieux Procede d'amplification d'une sequence d'un acide nucleique cible
AU735416B2 (en) * 1996-11-06 2001-07-05 Sequenom, Inc. Dna diagnostics based on mass spectrometry
US5962665A (en) * 1997-06-16 1999-10-05 Abbott Laboratories Nucleic acid primers and probes for detecting HIV-1 and HIV-2
US6849400B1 (en) 1997-07-23 2005-02-01 Gen-Probe Incorporated Methods for detecting and measuring spliced nucleic acids
WO1999005161A1 (en) 1997-07-25 1999-02-04 Ligand Pharmaceuticals Incorporated HUMAN PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA (PPARη) GENE REGULATORY SEQUENCES AND USES THEREFOR
ES2438578T3 (es) 1997-08-08 2014-01-17 Biomerieux B.V. Secuencias de ácidos nucleicos que se pueden usar como cebadores y sondas en la amplificación y detección de todos los subtipos del VIH-1
JP2002509694A (ja) 1997-11-04 2002-04-02 ロシュ ダイアグノスティックス ゲーエムベーハー 特異的かつ高感度な核酸検出方法
CA2311239C (en) * 1997-12-12 2004-03-16 The Regents Of The University Of California Methods for defining cell types
US20040002079A1 (en) * 1998-02-11 2004-01-01 Gunn Robert B. Sodium-phosphate cotransporter in lithium therapy for the treatment of mental illness
PT1056884E (pt) * 1998-02-27 2002-06-28 Pamgene Bv Processo para a amplificacao nao especifica de acido nucleico
EP1075328B1 (de) * 1998-05-01 2005-11-16 Gen-Probe Incorporated Automatisiertes diagnostisches analyseverfahren
ATE269417T1 (de) * 1998-07-23 2004-07-15 Gen Probe Inc Verfahren zur erkennung und messung von gespleisten nukleinsäuren
WO2000006779A1 (en) 1998-07-31 2000-02-10 Gen-Probe Incorporated Reversible inhibiting probes
US20030049657A1 (en) * 1998-11-13 2003-03-13 Cherry Joshua L. Use of primers containing non-replicatable residues for improved cycle-sequencing of nucleic acids
ATE304061T1 (de) 1999-07-23 2005-09-15 Gen Probe Inc Polynukleotid amplifizierungsverfahren
GB9917816D0 (en) * 1999-07-29 1999-09-29 Cytocell Ltd Chemically modified probes used to regulate nucleic acid amplification assays
NZ517121A (en) 1999-09-13 2004-05-28 Nugen Technologies Inc Methods and compositions for linear isothermal amplification of polynucleotide sequences
US6692918B2 (en) * 1999-09-13 2004-02-17 Nugen Technologies, Inc. Methods and compositions for linear isothermal amplification of polynucleotide sequences
US6582938B1 (en) 2001-05-11 2003-06-24 Affymetrix, Inc. Amplification of nucleic acids
WO2001064959A1 (en) * 2000-03-02 2001-09-07 Akzo Nobel N.V. Detection of hepatitis b virus rna
EP1294751B1 (de) 2000-03-31 2014-03-05 Merial Limited Gaba-abhängige chloridkanäle aus dermacentor variabilis
US6534292B1 (en) * 2000-05-08 2003-03-18 Genencor International, Inc. Methods for forming recombined nucleic acids
US7846733B2 (en) * 2000-06-26 2010-12-07 Nugen Technologies, Inc. Methods and compositions for transcription-based nucleic acid amplification
US6686156B2 (en) * 2000-06-26 2004-02-03 Nugen Technologies, Inc. Methods and compositions for transcription-based nucleic acid amplification
CA2731495C (en) 2000-09-01 2015-02-03 Gen-Probe Incorporated Amplification of hiv-1 sequences for detection of sequences associated with drug-resistance mutations
US6815164B2 (en) 2000-10-06 2004-11-09 Nugen Technologies, Inc. Methods and probes for detection and/or quantification of nucleic acid sequences
ATE475720T1 (de) * 2000-12-13 2010-08-15 Nugen Technologies Inc Methoden und zusammensetzungen zur generierung einer vielzahl von kopien von nukleinsäuresequenzen und methoden zur detektion derselben
US6794141B2 (en) 2000-12-22 2004-09-21 Arcturus Bioscience, Inc. Nucleic acid amplification
US6770752B2 (en) 2001-01-09 2004-08-03 Becton, Dickinson And Company Sequences for detection of HIV-1
KR20030088035A (ko) * 2001-03-07 2003-11-15 바이오메리욱스 비.브이. 전사 기초한 증폭을 이용하는 dna의 증폭 및 검출 방법
US7094536B2 (en) 2001-03-09 2006-08-22 Nugen Technologies, Inc. Methods and compositions for amplification of RNA sequences
AU2002252279B2 (en) 2001-03-09 2005-05-12 Nugen Technologies, Inc. Methods and compositions for amplification of RNA sequences
US7208282B2 (en) * 2001-05-31 2007-04-24 Merck & Co., Inc. Rhesus monkey, dog and ferret melanin-concentrating hormone type 2 receptor
US7074558B2 (en) * 2001-06-07 2006-07-11 Pbi Technology, Inc. Nucleic acid amplification using an RNA polymerase and DNA/RNA mixed polymer intermediate products
TWI335938B (en) * 2001-08-15 2011-01-11 Rna replication and amplification
US20050042629A1 (en) 2002-09-13 2005-02-24 Applera Corporation Thermus scotoductus nucleic acid polymerases
AU2002346498A1 (en) 2001-11-30 2003-06-17 Applera Corporation Thermus brockianus nucleic acid polymerases
WO2003048309A2 (en) 2001-11-30 2003-06-12 Applera Corporation Thermus thermophilus nucleic acid polymerases
KR100446621B1 (ko) * 2001-12-18 2004-09-07 삼성전자주식회사 다중 중합효소 연쇄반응에 의한 mody3유전자의 증폭을 위한 프라이머 세트
WO2003064679A2 (en) * 2002-01-30 2003-08-07 Id Biomedical Corporation Methods for detecting vancomycin-resistant microorganisms and compositions therefor
CA2478875A1 (en) * 2002-03-11 2003-09-25 Nugen Technologies, Inc. Methods for generating double stranded dna comprising a 3' single stranded portion and uses of these complexes for recombination
AU2003220249A1 (en) * 2002-03-15 2003-09-29 Arcturus Bioscience, Inc. Improved nucleic acid amplification
US20040005614A1 (en) * 2002-05-17 2004-01-08 Nurith Kurn Methods for fragmentation, labeling and immobilization of nucleic acids
WO2003106714A1 (en) * 2002-06-14 2003-12-24 Gen-Probe Incorporated Compositions and methods for detecting hepatitis b virus
US7074561B2 (en) 2002-10-22 2006-07-11 Biomerieux, Inc. Isothermal amplification based assay for the detection and quantitation of alpha-fetoprotein mRNA
US6852494B2 (en) * 2003-01-10 2005-02-08 Linden Technologies, Inc. Nucleic acid amplification
EP1613778B1 (de) * 2003-04-14 2014-11-26 Nugen Technologies, Inc. Globale amplifizierung unter verwendung von zufallsgeprimeten zusammen gesetzten primern
AU2004276722B2 (en) 2003-05-19 2009-03-12 Gen-Probe Incorporated Compositions, methods and kits for determining the presence of trichomonas vaginalis in a test sample
US20050176125A1 (en) * 2003-12-23 2005-08-11 Rosetta Inpharmatics Llc Alternatively spliced isoform of CDC25A phosphatase and methods of use
JP2007524407A (ja) 2003-12-29 2007-08-30 ニューゲン テクノロジーズ, インコーポレイテッド 核酸のメチル化状態を分析するための方法、ならびに核酸の断片化、標識化および固定化のための方法
US10066268B2 (en) 2004-05-07 2018-09-04 The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. Methods of diagnosing or treating prostate cancer using the ERG gene, alone or in combination with other over or under expressed genes in prostate cancer
US20050266469A1 (en) * 2004-05-25 2005-12-01 Raymond Christopher K Alternatively spliced isoforms of checkpoint kinase 1 (CHK1)
EP1758981A4 (de) 2004-05-28 2013-01-16 Wafergen Inc Vorrichtungen und verfahren für multiplex-analysen
US7150969B2 (en) * 2004-06-04 2006-12-19 Rosetta Inpharmatics Llc Alternatively spliced isoform of acetyl-CoA carboxylase 2 (ACC2)
US20050277121A1 (en) 2004-06-11 2005-12-15 Ambion, Inc. Crude biological derivatives competent for nucleic acid detection
JP4658660B2 (ja) 2005-03-30 2011-03-23 株式会社日立ハイテクノロジーズ 核酸検出法
US8124335B2 (en) 2005-05-06 2012-02-28 Gen-Probe Incorporated Compositions and assays to detect influenza virus A and B nucleic acids
KR101569307B1 (ko) 2005-05-09 2015-11-13 테라노스, 인코포레이티드 현장진료 유체 시스템 및 그 용도
EP2623596B1 (de) 2005-05-13 2014-10-08 Wako Pure Chemical Industries, Ltd. Primer und Sonde zur Verwendung bei der Erkennung von Mykobacterium kansasii und diesbezügliche Verfahren zur Erkennung von Mykobacterium kansasii
US7550264B2 (en) 2005-06-10 2009-06-23 Datascope Investment Corporation Methods and kits for sense RNA synthesis
US7939258B2 (en) 2005-09-07 2011-05-10 Nugen Technologies, Inc. Nucleic acid amplification procedure using RNA and DNA composite primers
US9957569B2 (en) * 2005-09-12 2018-05-01 The Regents Of The University Of Michigan Recurrent gene fusions in prostate cancer
WO2007033187A2 (en) 2005-09-12 2007-03-22 The Regents Of The University Of Michigan Recurrent gene fusions in prostate cancer
US20100035331A1 (en) 2006-02-15 2010-02-11 Tosoh Corporation Method for extracting of nucleic acid from biological material
EP1992703B1 (de) 2006-03-13 2012-04-11 Wako Pure Chemical Industries, Ltd. Verfahren zur erkennung eines mutierten gens
US11287421B2 (en) 2006-03-24 2022-03-29 Labrador Diagnostics Llc Systems and methods of sample processing and fluid control in a fluidic system
US8741230B2 (en) 2006-03-24 2014-06-03 Theranos, Inc. Systems and methods of sample processing and fluid control in a fluidic system
WO2007129628A1 (ja) 2006-05-02 2007-11-15 Wako Pure Chemical Industries, Ltd. マイコバクテリウム・イントラセルラーレ検出用プライマー及びプローブ、並びにこれを用いたマイコバクテリウム・イントラセルラーレの検出方法
US11001881B2 (en) 2006-08-24 2021-05-11 California Institute Of Technology Methods for detecting analytes
CA2659543C (en) 2006-06-06 2015-12-29 Gen-Probe Incorporated Tagged oligonucleotides and their use in nucleic acid amplification methods
EP2038429B1 (de) * 2006-06-30 2013-08-21 Nugen Technologies, Inc. Verfahren zur fragmentierung und etikettierung von nukleinsäuren
US7501254B2 (en) 2006-07-20 2009-03-10 Ghc Technologies, Inc. Methods and compositions for amplification and capture of nucleic acid sequences
US11525156B2 (en) 2006-07-28 2022-12-13 California Institute Of Technology Multiplex Q-PCR arrays
US8048626B2 (en) 2006-07-28 2011-11-01 California Institute Of Technology Multiplex Q-PCR arrays
EP2057465A4 (de) 2006-08-09 2010-04-21 Homestead Clinical Corp Organspezifische proteine und anwendungsverfahren dafür
US11560588B2 (en) 2006-08-24 2023-01-24 California Institute Of Technology Multiplex Q-PCR arrays
EP1921156A1 (de) * 2006-11-10 2008-05-14 bioMerieux B.V. Verbesserte multiplexe Nukleinsäureamplifikation mittels blockierter Primer
CN104531684A (zh) 2006-12-18 2015-04-22 和光纯药工业株式会社 鸟分枝杆菌检测用引物和探针、以及使用它们检测鸟分枝杆菌的方法
WO2008080029A2 (en) * 2006-12-21 2008-07-03 Gen-Probe Incorporated Methods and compositions for nucleic acid amplification
KR20090100460A (ko) * 2007-01-17 2009-09-23 메리디안 바이오사이언스 인크. 루프-매개 등온 증폭법(lamp)에 유용한 안정적인 시약 및 키트
GB0701253D0 (en) 2007-01-23 2007-02-28 Diagnostics For The Real World Nucleic acid amplification and testing
JP4340298B2 (ja) 2007-03-01 2009-10-07 株式会社日立ハイテクノロジーズ 核酸回収方法及び核酸回収装置
EP1978111B1 (de) 2007-04-02 2013-03-27 Gen-Probe Incorporated Zusammensetzungen, Kits und zugehörige Verfahren zur Erkennung und/oder Überwachung von Pseudomonas aeruginosa
JP2009000044A (ja) 2007-06-21 2009-01-08 Hitachi High-Technologies Corp 核酸増幅法
JP2009000063A (ja) 2007-06-22 2009-01-08 Tosoh Corp 改良されたノロウイルスrna検出方法
JP5433572B2 (ja) * 2007-07-06 2014-03-05 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン Mipol1−etv1遺伝子再編成
CA2692441C (en) 2007-07-06 2020-01-21 The Regents Of The University Of Michigan Solute carrier family 45 member 3 (slc45a3) and ets family gene fusions in prostate cancer
CA3170924A1 (en) 2007-10-02 2009-04-09 Labrador Diagnostics Llc Modular point-of-care devices and uses thereof
CN101883852A (zh) 2007-10-04 2010-11-10 东曹株式会社 军团菌rRNA扩增用引物、检测方法及其检测试剂盒
JP5299986B2 (ja) * 2007-11-01 2013-09-25 国立大学法人山口大学 核酸の定量方法
WO2009085221A2 (en) 2007-12-21 2009-07-09 Biomerieux Sa Detection of methicillin-resistant staphylococcus aureus
WO2009099037A1 (ja) 2008-02-08 2009-08-13 Wako Pure Chemical Industries, Ltd. クラミドフィラ・キャビエ検出用プライマー及びプローブ、並びにこれを用いたクラミドフィラ・キャビエの検出方法
US8034568B2 (en) * 2008-02-12 2011-10-11 Nugen Technologies, Inc. Isothermal nucleic acid amplification methods and compositions
WO2009117698A2 (en) 2008-03-21 2009-09-24 Nugen Technologies, Inc. Methods of rna amplification in the presence of dna
US20090304714A1 (en) * 2008-03-25 2009-12-10 The Regents Of The University Of Michigan IKKi Inhibitor Therapies and Screening Methods, and Related IKKi Diagnostics
JP5733796B2 (ja) 2008-05-13 2015-06-10 ジェン−プロウブ インコーポレイテッド 標的核酸配列の選択的ハイブリダイゼーションおよび捕捉における使用のため不活化可能型標的捕捉オリゴマー
CN103224932A (zh) 2008-05-28 2013-07-31 和光纯药工业株式会社 胞内分枝杆菌检测用引物和探针、以及使用该引物和探针检测胞内分枝杆菌的方法
AU2009253675A1 (en) 2008-05-28 2009-12-03 Genomedx Biosciences, Inc. Systems and methods for expression-based discrimination of distinct clinical disease states in prostate cancer
WO2009158119A2 (en) 2008-05-30 2009-12-30 Gen-Probe Incorporated Compositions, kits and related methods for the detection and/or monitoring of salmonella
EP2326957B1 (de) * 2008-09-03 2013-06-12 Abbott Molecular Inc. Tests und kits zur bestimmung von hiv-1-tropismus
WO2010030461A2 (en) * 2008-09-12 2010-03-18 Promega Corporation Assessing expression of endogenous and exogenous genes
JP5428272B2 (ja) 2008-10-06 2014-02-26 東ソー株式会社 サバイビンmRNAの測定方法
WO2010078374A1 (en) 2008-12-30 2010-07-08 Gen-Probe Incorporated Compositions, kits and related methods for the detection and/or monitoring of listeria
BRPI1004572A2 (pt) 2009-01-09 2016-04-05 Univ Michigan "fusões genéticas recorrentes em câncer
WO2010114842A1 (en) 2009-03-30 2010-10-07 Ibis Biosciences, Inc. Bioagent detection systems, devices, and methods
CA2768768C (en) 2009-06-23 2021-08-24 Gen-Probe Incorporated Compositions and methods for detecting nucleic acid from mollicutes
EP2449132B1 (de) 2009-07-01 2015-05-13 Gen-Probe Incorporated Verfahren und zusammensetzungen zur erweiterung von nukleinsäuren
US20110059453A1 (en) * 2009-08-23 2011-03-10 Affymetrix, Inc. Poly(A) Tail Length Measurement by PCR
EP2473624B1 (de) 2009-08-31 2019-05-01 Gen-Probe Incorporated Test für dengue-virus
WO2011034906A2 (en) * 2009-09-17 2011-03-24 The Regents Of The University Of Michigan Recurrent gene fusions in prostate cancer
DK2501716T3 (en) 2009-11-19 2015-04-07 Solis Biodyne Oü Formations to increase polypeptidstabilitet and activity and related practices
CA2787327C (en) 2010-01-22 2015-09-15 Damon Kittredge Getman Probes for detecting the presence of trichomonas vaginalis in a sample
EP2557156B1 (de) 2010-03-23 2015-02-11 Wako Pure Chemical Industries, Ltd. Primer und sonde zur detektion von chlamydia trachomatis und verfahren zur detektion von chlamydia trachomatis damit
EP2561094B1 (de) 2010-04-21 2017-03-29 Gen-Probe Incorporated Zusammensetzungen, verfahren und kits für den nachweis von herpes-simplex-virusnukleinsäure
EP2563380B1 (de) 2010-04-26 2018-05-30 aTyr Pharma, Inc. Innovative entdeckung therapeutischer, diagnostischer und antikörperhaltiger zusammensetzungen im zusammenhang mit proteinfragmenten der cysteinyl-trna-synthetase
AU2011248614B2 (en) 2010-04-27 2017-02-16 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of isoleucyl tRNA synthetases
EP2563911B1 (de) 2010-04-28 2021-07-21 aTyr Pharma, Inc. Innovative entdeckung therapeutischer, diagnostischer und antikörperhaltiger zusammensetzungen im zusammenhang mit proteinfragmenten von alanyl-trna-synthetasen
CA2797393C (en) 2010-04-29 2020-03-10 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of valyl trna synthetases
US9068177B2 (en) 2010-04-29 2015-06-30 Atyr Pharma, Inc Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glutaminyl-tRNA synthetases
AU2011248490B2 (en) 2010-04-29 2016-11-10 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of Asparaginyl tRNA synthetases
EP2566515B1 (de) 2010-05-03 2017-08-02 aTyr Pharma, Inc. Innovative entdeckung von therapeutischen und diagnostischen mitteln sowie antikörperzusammensetzungen im zusammenhang mit proteinfragmenten von arginyl-trna-synthetasen
US9034321B2 (en) 2010-05-03 2015-05-19 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of phenylalanyl-alpha-tRNA synthetases
CN103140233B (zh) 2010-05-03 2017-04-05 Atyr 医药公司 与甲硫氨酰‑tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的发现
CA2798139C (en) 2010-05-04 2019-09-24 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of p38 multi-trna synthetase complex
EP2568996B1 (de) 2010-05-14 2017-10-04 aTyr Pharma, Inc. Therapeutische, diagnostische und antikörperhaltige zusammensetzungen im zusammenhang mit proteinfragmenten von phenylalanyl-beta-trna-synthetasen
CN103118694B (zh) 2010-06-01 2016-08-03 Atyr医药公司 与赖氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的发现
CA2802741C (en) 2010-06-30 2020-07-07 Gen-Probe Incorporated Method and apparatus for identifying analyte-containing samples using single-read determination of analyte and process control signals
ES2652600T3 (es) 2010-07-07 2018-02-05 The Regents Of The University Of Michigan Diagnóstico y tratamiento de cáncer de mama
EP2593125B1 (de) 2010-07-12 2017-11-01 aTyr Pharma, Inc. Innovative erkennung therapeutischer, diagnostischer und antikörperhaltiger zusammensetzungen in zusammenhang mit proteinfragmenten von glycyl-trna-synthetasen
US9234249B2 (en) 2010-07-12 2016-01-12 Gen-Probe Incorporated Compositions and assays to detect swine H1N1 influenza A virus, seasonal H1 influenza A virus and seasonal H3 influenza A virus nucleic acids
CN103543282A (zh) 2010-07-23 2014-01-29 贝克曼考尔特公司 用于处理化验盒的系统
EP2608801B1 (de) 2010-08-25 2019-08-21 aTyr Pharma, Inc. Innovative erkennung therapeutischer, diagnostischer und antikörperhaltiger zusammensetzungen in zusammenhang mit proteinfragmenten von tyrosyl-trna-synthetasen
EP3438289A1 (de) 2010-10-04 2019-02-06 Gen-Probe Prodesse, Inc. Zusammensetzungen, verfahren und kits für den nachweis von adenovirus-nukleinsäuren
US8945556B2 (en) 2010-11-19 2015-02-03 The Regents Of The University Of Michigan RAF gene fusions
WO2012068383A2 (en) 2010-11-19 2012-05-24 The Regents Of The University Of Michigan ncRNA AND USES THEREOF
CN106290160A (zh) 2011-01-21 2017-01-04 提拉诺斯公司 样品使用最大化的系统和方法
EP2675275B1 (de) 2011-02-14 2017-12-20 The Regents Of The University Of Michigan Zusammensetzungen und verfahren zur behandlung von adipositas und damit zusammenhängenden erkrankungen
EP3272886B1 (de) 2011-04-25 2019-09-25 Gen-Probe Incorporated Zusammensetzungen und verfahren zum nachweis von bv-assoziierter bakterieller nukleinsäure
CA2835942C (en) 2011-05-19 2019-01-22 Sequenom, Inc. Products and processes for multiplex nucleic acid identification
EP2753712B1 (de) 2011-09-06 2017-03-22 Gen-Probe Incorporated Geschlossene nukleinsäurestrukturen
AU2012304520B2 (en) 2011-09-06 2016-06-16 Gen-Probe Incorporated Circularized templates for sequencing
US8475739B2 (en) 2011-09-25 2013-07-02 Theranos, Inc. Systems and methods for fluid handling
US8435738B2 (en) 2011-09-25 2013-05-07 Theranos, Inc. Systems and methods for multi-analysis
US9619627B2 (en) 2011-09-25 2017-04-11 Theranos, Inc. Systems and methods for collecting and transmitting assay results
US9664702B2 (en) 2011-09-25 2017-05-30 Theranos, Inc. Fluid handling apparatus and configurations
US9268915B2 (en) 2011-09-25 2016-02-23 Theranos, Inc. Systems and methods for diagnosis or treatment
US8840838B2 (en) 2011-09-25 2014-09-23 Theranos, Inc. Centrifuge configurations
US20140170735A1 (en) 2011-09-25 2014-06-19 Elizabeth A. Holmes Systems and methods for multi-analysis
US9632102B2 (en) 2011-09-25 2017-04-25 Theranos, Inc. Systems and methods for multi-purpose analysis
US8380541B1 (en) 2011-09-25 2013-02-19 Theranos, Inc. Systems and methods for collecting and transmitting assay results
WO2013044097A1 (en) 2011-09-21 2013-03-28 Gen-Probe Incorporated Methods for amplifying nucleic acid using tag-mediated displacement
US9810704B2 (en) 2013-02-18 2017-11-07 Theranos, Inc. Systems and methods for multi-analysis
EP2758510A4 (de) 2011-09-25 2015-05-06 Theranos Inc Systeme und verfahren für mehrfachanalyse
US9250229B2 (en) 2011-09-25 2016-02-02 Theranos, Inc. Systems and methods for multi-analysis
US10012664B2 (en) 2011-09-25 2018-07-03 Theranos Ip Company, Llc Systems and methods for fluid and component handling
FR2981088B1 (fr) 2011-10-06 2013-11-29 Biomerieux Sa Arn polymerases mutees
SG10201510189WA (en) 2011-10-19 2016-01-28 Nugen Technologies Inc Compositions And Methods For Directional Nucleic Acid Amplification And Sequencing
AU2012330817A1 (en) 2011-11-04 2014-05-22 Oslo Universitetssykehus Hf Methods and biomarkers for analysis of colorectal cancer
WO2013067413A1 (en) 2011-11-04 2013-05-10 Gen-Probe Incorporated Molecular assay reagents and methods
WO2013070754A1 (en) 2011-11-07 2013-05-16 Beckman Coulter, Inc. Robotic arm
EP2776844B1 (de) 2011-11-07 2020-09-30 Beckman Coulter, Inc. Probenbehälterdetektion
EP2776847A1 (de) 2011-11-07 2014-09-17 Beckman Coulter, Inc. Magnetische dämpfung für probentransportsystem
WO2013070755A2 (en) 2011-11-07 2013-05-16 Beckman Coulter, Inc. Centrifuge system and workflow
CN104053997B (zh) 2011-11-07 2016-12-21 贝克曼考尔特公司 用于处理样本的系统和方法
EP2776846B1 (de) 2011-11-07 2019-08-21 Beckman Coulter, Inc. Aliquotierungssystem und arbeitsablauf
DE102011120550B4 (de) 2011-12-05 2013-11-07 Gen-Probe Prodesse, Inc. Zusammensetzungen, Verfahren und Kits zur Detektion von Adenovirusnukleinsäuren
EP2795333A4 (de) 2011-12-20 2016-02-17 Univ Michigan Pseudogene und verwendungen davon
WO2013096838A2 (en) 2011-12-22 2013-06-27 Ibis Biosciences, Inc. Systems and methods for isolating nucleic acids
US9334491B2 (en) 2011-12-22 2016-05-10 Ibis Biosciences, Inc. Systems and methods for isolating nucleic acids from cellular samples
CA2858284A1 (en) 2011-12-23 2013-06-27 Biomerieux Detection of meca variant strains of methicillin-resistant staphylococcus aureus
WO2013101935A1 (en) 2011-12-27 2013-07-04 Ibis Biosciences, Inc. Bioagent detection oligonucleotides
AU2013208757A1 (en) 2012-01-09 2014-07-24 Oslo Universitetssykehus Hf Methods and biomarkers for analysis of colorectal cancer
WO2013112923A1 (en) 2012-01-26 2013-08-01 Nugen Technologies, Inc. Compositions and methods for targeted nucleic acid sequence enrichment and high efficiency library generation
EP2814514B1 (de) 2012-02-16 2017-09-13 Atyr Pharma, Inc. Histidyl-trna-synthetasen zur behandlung von autoimmun- und entzündungserkrankungen
EP2817627A2 (de) 2012-02-21 2014-12-31 Oslo Universitetssykehus HF Verfahren und biomarker zur erkennung und prognose von gebärmutterhalskrebs
CA2866254A1 (en) 2012-03-06 2013-09-12 Oslo Universitetssykehus Hf Gene signatures associated with efficacy of postmastectomy radiotherapy in breast cancer
US9732387B2 (en) 2012-04-03 2017-08-15 The Regents Of The University Of Michigan Biomarker associated with irritable bowel syndrome and Crohn's disease
AU2013205110B2 (en) 2012-04-24 2016-10-13 Gen-Probe Incorporated Compositions, Methods and Kits to Detect Herpes Simplex Virus Nucleic Acids
EP2861787B1 (de) 2012-06-18 2017-09-20 Nugen Technologies, Inc. Zusammensetzungen und verfahren zur negativen auswahl von unerwünschten nukleinsäuresequenzen
WO2014005076A2 (en) 2012-06-29 2014-01-03 The Regents Of The University Of Michigan Methods and biomarkers for detection of kidney disorders
US20150011396A1 (en) 2012-07-09 2015-01-08 Benjamin G. Schroeder Methods for creating directional bisulfite-converted nucleic acid libraries for next generation sequencing
WO2014028884A2 (en) 2012-08-16 2014-02-20 Genomedx Biosciences, Inc. Cancer diagnostics using biomarkers
KR20150055002A (ko) 2012-09-11 2015-05-20 테라노스, 인코포레이티드 생물학적 서명을 이용한 정보 관리 시스템 및 방법
ES2701235T3 (es) 2012-09-28 2019-02-21 Bna Inc Método de abrazadera de BNA
IN2015DN02893A (de) 2012-10-04 2015-09-11 Univ Leland Stanford Junior
US20160046997A1 (en) 2012-10-18 2016-02-18 Oslo Universitetssykehus Hf Biomarkers for cervical cancer
AU2013352339B2 (en) 2012-11-27 2019-07-04 Pontificia Universidad Catolica De Chile Compositions and methods for diagnosing thyroid tumors
MX354033B (es) 2013-02-18 2018-02-09 Theranos Ip Co Llc Sistemas y métodos para recolectar y transmitir resultados de ensayos.
CA2905425A1 (en) 2013-03-13 2014-10-02 Abbott Molecular Inc. Methods of isolating nucleic acid using a lysis buffer containing ethanol
WO2014160254A2 (en) 2013-03-14 2014-10-02 Abbott Molecular Inc. Minimizing errors using uracil-dna-n-glycosylase
AU2013202805B2 (en) 2013-03-14 2015-07-16 Gen-Probe Incorporated System and method for extending the capabilities of a diagnostic analyzer
CN105378107A (zh) 2013-03-14 2016-03-02 雅培分子公司 多重甲基化-特异性扩增系统和方法
CA2905410A1 (en) 2013-03-15 2014-09-25 Abbott Molecular Inc. Systems and methods for detection of genomic copy number changes
WO2014150910A1 (en) 2013-03-15 2014-09-25 Ibis Biosciences, Inc. Dna sequences to assess contamination in dna sequencing
WO2014144092A1 (en) 2013-03-15 2014-09-18 Nugen Technologies, Inc. Sequential sequencing
AU2014241191A1 (en) 2013-03-27 2015-10-22 Sample Technologies, Inc. Recombinant phage and bacterial detection methods
CA2910553A1 (en) 2013-04-30 2014-11-06 Universite De Montreal Novel biomarkers for acute myeloid leukemia
ES2727898T3 (es) 2013-05-02 2019-10-21 Univ Michigan Regents Amlexanox deuterado con estabilidad metabólica mejorada
JP2016521996A (ja) 2013-06-19 2016-07-28 サンプルシックス テクノロジーズ,インコーポレイティド ファージベースの細菌検出アッセイ
US10392670B2 (en) 2013-07-25 2019-08-27 Dch Molecular Diagnostics, Inc. Methods and compositions for detecting bacterial contamination
US11545241B1 (en) 2013-09-07 2023-01-03 Labrador Diagnostics Llc Systems and methods for analyte testing and data management
EP3068883B1 (de) 2013-11-13 2020-04-29 Nugen Technologies, Inc. Zusammensetzungen und verfahren zur identifizierung einer duplikatsequenzierungslesung
CN109706222A (zh) 2013-12-11 2019-05-03 安可济控股有限公司 用于检测罕见序列变体的组合物和方法
US11859246B2 (en) 2013-12-11 2024-01-02 Accuragen Holdings Limited Methods and compositions for enrichment of amplification products
US11286519B2 (en) 2013-12-11 2022-03-29 Accuragen Holdings Limited Methods and compositions for enrichment of amplification products
AU2015209103B2 (en) * 2014-01-27 2021-07-01 Archerdx, Llc Isothermal methods and related compositions for preparing nucleic acids
US9745614B2 (en) 2014-02-28 2017-08-29 Nugen Technologies, Inc. Reduced representation bisulfite sequencing with diversity adaptors
US10760109B2 (en) 2014-06-06 2020-09-01 The Regents Of The University Of Michigan Compositions and methods for characterizing and diagnosing periodontal disease
WO2016077426A1 (en) 2014-11-11 2016-05-19 Abbott Molecular Inc. Hybridization probes and methods
US10641772B2 (en) 2015-02-20 2020-05-05 Takara Bio Usa, Inc. Method for rapid accurate dispensing, visualization and analysis of single cells
US9708647B2 (en) 2015-03-23 2017-07-18 Insilixa, Inc. Multiplexed analysis of nucleic acid hybridization thermodynamics using integrated arrays
US10125198B2 (en) 2015-04-17 2018-11-13 Distributed Bio, Inc. Method for mass humanization of non-human antibodies
CA2983227A1 (en) 2015-04-24 2016-10-27 Agena Bioscience, Inc. Multiplex methods for detection and quantification of minor variants
AU2016250841A1 (en) 2015-04-24 2017-11-02 Agena Bioscience, Inc. Multiplexed method for the identification and quantitation of minor alleles and polymorphisms
AU2016252998B2 (en) 2015-04-24 2021-11-04 Atila Biosystems Incorporated Amplification with primers of limited nucleotide composition
JP2018516594A (ja) * 2015-05-18 2018-06-28 カリミューン, インコーポレーティッド Hiv−1とレンチウイルスベクターとを識別する方法
JP6840391B2 (ja) 2015-06-19 2021-03-10 セラ プログノスティックス, インコーポレイテッド 早産を予測するためのバイオマーカーの対
US9499861B1 (en) 2015-09-10 2016-11-22 Insilixa, Inc. Methods and systems for multiplex quantitative nucleic acid amplification
EP3359693A4 (de) 2015-10-09 2019-03-06 Accuragen Holdings Limited Verfahren und zusammensetzungen zur anreicherung von amplifikationsprodukten
EP3383994A4 (de) 2015-12-03 2019-08-28 Accuragen Holdings Limited Verfahren und zusammensetzungen zum formen von ligationsprodukten
EP3407974A4 (de) 2016-01-29 2019-08-28 The Regents Of The University Of Michigan Amlexanox-analoga
WO2017155858A1 (en) 2016-03-07 2017-09-14 Insilixa, Inc. Nucleic acid sequence identification using solid-phase cyclic single base extension
CA3024630A1 (en) 2016-05-16 2017-11-23 Accuragen Holdings Limited Method of improved sequencing by strand identification
US11091795B2 (en) 2016-07-11 2021-08-17 Arizona Board Of Regents On Behalf Of The University Of Arizona Compositions and methods for diagnosing and treating arrhythmias
US11460405B2 (en) 2016-07-21 2022-10-04 Takara Bio Usa, Inc. Multi-Z imaging and dispensing with multi-well devices
SG10202111825YA (en) 2016-08-15 2021-12-30 Accuragen Holdings Ltd Compositions and methods for detecting rare sequence variants
EP3504348B1 (de) 2016-08-24 2022-12-14 Decipher Biosciences, Inc. Verwendung von genomischen signaturen zur vorhersage des ansprechens von patienten mit prostatakrebs auf postoperative strahlentherapie
JP6997773B2 (ja) 2016-09-15 2022-01-18 アーチャーディーエックス, エルエルシー 無細胞dnaの分析用の核酸サンプル調製の方法
EP3933039A1 (de) 2016-09-15 2022-01-05 ArcherDX, LLC Verfahren für die zubereitung von nukleinsäureproben
JP6767833B2 (ja) 2016-09-29 2020-10-14 日本特殊陶業株式会社 加熱装置
EP3519554A4 (de) 2016-09-30 2020-05-20 The Governing Council Of The University Of Toronto System zur identifizierung und zum targeting von zellen in einer heterogenen population zur selektiven extraktion von zellgehalt
US10427162B2 (en) 2016-12-21 2019-10-01 Quandx Inc. Systems and methods for molecular diagnostics
WO2018127786A1 (en) 2017-01-06 2018-07-12 Oslo Universitetssykehus Hf Compositions and methods for determining a treatment course of action
AU2018210695A1 (en) 2017-01-20 2019-08-08 The University Of British Columbia Molecular subtyping, prognosis, and treatment of bladder cancer
EP3593140A4 (de) 2017-03-09 2021-01-06 Decipher Biosciences, Inc. Subtypisierung von prostatakrebs zur vorhersage der reaktion auf eine hormontherapie
CA3057325C (en) 2017-03-24 2024-03-12 Gen-Probe Incorporated Cover assembly and related methods of use
EP3622087A4 (de) 2017-05-12 2021-06-16 Decipher Biosciences, Inc. Genetische signaturen zur vorhersage der prostatakrebsmetastasierung und identifizierung von tumoraggressivität
WO2019036032A1 (en) 2017-08-18 2019-02-21 Sera Prognostics, Inc PREGNANCY CLOCK PROTEINS FOR PREDICTING THE DATE AND MOMENT OF BIRTH
US11099202B2 (en) 2017-10-20 2021-08-24 Tecan Genomics, Inc. Reagent delivery system
US11203782B2 (en) 2018-03-29 2021-12-21 Accuragen Holdings Limited Compositions and methods comprising asymmetric barcoding
CA3108105A1 (en) 2018-08-08 2020-02-13 Gen-Probe Incorporated Compositions, methods and kits for detecting mycoplasma genitalium
EP3937780A4 (de) 2019-03-14 2022-12-07 InSilixa, Inc. Verfahren und systeme zur zeitgesteuerten fluoreszenzbasierten detektion
EP4018004A1 (de) 2019-08-23 2022-06-29 Gen-Probe Incorporated Zusammensetzungen, verfahren und kits zum nachweis von treponema pallidum
EP4025715A1 (de) 2019-09-05 2022-07-13 Gen-Probe Incorporated Nachweis von chlamydia-trachomatis-nukleinsäurevarianten
WO2021252574A1 (en) 2020-06-10 2021-12-16 Sera Prognostics, Inc. Nucleic acid biomarkers for placental dysfunction
EP4381094A1 (de) 2021-08-03 2024-06-12 Wageningen Universiteit Argonautenbasiertes nukleinsäurenachweissystem
WO2023021330A1 (en) 2021-08-16 2023-02-23 University Of Oslo Compositions and methods for determining a treatment course of action
WO2023140731A1 (en) 2022-01-20 2023-07-27 Wageningen Universiteit Thermostable rna polymerase
WO2023152568A2 (en) 2022-02-10 2023-08-17 Oslo Universitetssykehus Hf Compositions and methods for characterizing lung cancer
WO2023175434A1 (en) 2022-03-15 2023-09-21 Diagenode S.A. Detection of methylation status of a dna sample

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA559709A (en) * 1958-07-01 International Standard Electric Corporation Travelling wave tubes
US4957858A (en) * 1986-04-16 1990-09-18 The Salk Instute For Biological Studies Replicative RNA reporter systems
US4683202A (en) * 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
ES8706823A1 (es) * 1985-03-28 1987-06-16 Cetus Corp Un procedimiento para detectar la presencia o ausencia de al menos una secuencia especifica de acidos nucleicos en una muestra
US4683195A (en) * 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
AU606043B2 (en) * 1985-03-28 1991-01-31 F. Hoffmann-La Roche Ag Detection of viruses by amplification and hybridization
US5075211A (en) * 1986-03-26 1991-12-24 Genetic Systems Corporation Synthetic antigen for the detection of AIDS-related disease
CA1338457C (en) * 1986-08-22 1996-07-16 Henry A. Erlich Purified thermostable enzyme
IL86724A (en) * 1987-06-19 1995-01-24 Siska Diagnostics Inc Methods and kits for amplification and testing of nucleic acid sequences
US4994368A (en) * 1987-07-23 1991-02-19 Syntex (U.S.A.) Inc. Amplification method for polynucleotide assays
WO1989001050A1 (en) * 1987-07-31 1989-02-09 The Board Of Trustees Of The Leland Stanford Junior University Selective amplification of target polynucleotide sequences
CA1340807C (en) * 1988-02-24 1999-11-02 Lawrence T. Malek Nucleic acid amplification process
WO1990001068A1 (en) * 1988-07-22 1990-02-08 Life Technologies, Inc. Sequence specific assay for the detection of a nucleic acid molecule
HU216105B (hu) * 1988-12-16 1999-04-28 Akzo Nobel N.V. Amplifikációs eljárás önfenntartó szekvenciareplikációs rendszerrel
US5112734A (en) * 1989-05-26 1992-05-12 Gene-Trak Systems Target-dependent synthesis of an artificial gene for the synthesis of a replicatable rna
CA2020958C (en) * 1989-07-11 2005-01-11 Daniel L. Kacian Nucleic acid sequence amplification methods
US5194370A (en) * 1990-05-16 1993-03-16 Life Technologies, Inc. Promoter ligation activated transcription amplification of nucleic acid sequences

Also Published As

Publication number Publication date
KR920701478A (ko) 1992-08-11
DE69028257D1 (de) 1996-10-02
EP0731175A2 (de) 1996-09-11
AU650622B2 (en) 1994-06-30
ES2091225T3 (es) 1996-11-01
AU7415694A (en) 1994-11-24
EP0408295A3 (en) 1991-08-28
KR100242252B1 (ko) 2000-03-02
JPH04500759A (ja) 1992-02-13
GR3021704T3 (en) 1997-02-28
DE69028257T2 (de) 1997-01-09
DE69034177D1 (de) 2004-12-23
EP0731174A3 (de) 1998-03-25
JP2002355099A (ja) 2002-12-10
EP0731174A2 (de) 1996-09-11
PT94662A (pt) 1991-03-20
DE69034177T2 (de) 2005-10-27
AU677418B2 (en) 1997-04-24
JP3445131B2 (ja) 2003-09-08
FI911152A0 (fi) 1991-03-07
AU6166390A (en) 1991-02-22
JP2000350592A (ja) 2000-12-19
US5480784A (en) 1996-01-02
EP0731175A3 (de) 2004-05-26
JP3241717B2 (ja) 2001-12-25
DK0408295T3 (da) 1996-09-16
JP3350511B2 (ja) 2002-11-25
EP0408295A2 (de) 1991-01-16
NO910902D0 (no) 1991-03-07
IE902539A1 (en) 1991-02-27
WO1991001384A1 (en) 1991-02-07
EP0731174B1 (de) 2004-11-17
ATE141956T1 (de) 1996-09-15
EP0408295B1 (de) 1996-08-28
JPH1146778A (ja) 1999-02-23

Similar Documents

Publication Publication Date Title
ATE282716T1 (de) Verfahren zur amplifikation von nukleinsäuresequenzen
CA2020958A1 (en) Nucleic acid sequence amplification methods
ATE106948T1 (de) Verfahren zur amplifizierung von nukleinsäuren.
DE69333891D1 (de) Verfahren zur Nukleinsäurenamplifizierung, Zusammensetzung und Kit
ATE236269T1 (de) Ein elektrochemiluminescenter nachweis von nukleinsäuren auf basis der selbsttragenden sequenzreplikation
ES2104611T3 (es) Procedimiento de amplificacion mejorado de acidos nucleicos.
ATE257861T1 (de) Methoden und zusammensetzungen zur effizienten nukleinsaeuresequenzierung
DE69736667D1 (de) Verfahren zum nachweis und amplifikation von nukleinsäuresequenzen unter verbrauch von modifizierten oligonukleotiden mit erhöhter zielschmelztemperatur (tm)
ATE244259T1 (de) Verwendungen von fluoreszierenden n-nukleosiden und dessen analogen
DE3750774D1 (de) Chaotropisches verfahren zur schätzung von nukleinen säuren in einer biologischen probe.
DE69937223D1 (de) Verfahren zur synthese von nukleinsäuren
DE69330608D1 (de) Positionelle sequenzierung durch hybridisierung
Kacian et al. Kits for nucleic acid sequence amplification methods
DE68925844D1 (de) Verfahren zur Markierung einer Nucleinsäure-Sonde und Reagenzienkit zur Ausführung dieses Verfahrens
ATE105871T1 (de) Verfahren zur stabilisierung der hybridisierung von komplementären polynukleotidsequenzen.
ATE118823T1 (de) Schnelles verfahren zur identifizierung einer spezifischen sequenz von nukleinsäure.

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties