ATE340866T1 - Zusammensetzungen und verfahren für die gleichzeitige detektion und quantifizierung von einer mehrheit spezifischer nuklein säure sequenzen - Google Patents

Zusammensetzungen und verfahren für die gleichzeitige detektion und quantifizierung von einer mehrheit spezifischer nuklein säure sequenzen

Info

Publication number
ATE340866T1
ATE340866T1 AT95116199T AT95116199T ATE340866T1 AT E340866 T1 ATE340866 T1 AT E340866T1 AT 95116199 T AT95116199 T AT 95116199T AT 95116199 T AT95116199 T AT 95116199T AT E340866 T1 ATE340866 T1 AT E340866T1
Authority
AT
Austria
Prior art keywords
methods
quantification
majority
compositions
specific
Prior art date
Application number
AT95116199T
Other languages
English (en)
Inventor
Norman C Nelson
James S Woodhead
Ian Weeks
Azzouz Ben Cheikh
Original Assignee
Gen Probe Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gen Probe Inc filed Critical Gen Probe Inc
Application granted granted Critical
Publication of ATE340866T1 publication Critical patent/ATE340866T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D217/00Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D219/00Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6816Hybridisation assays characterised by the detection means
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00Chemistry: analytical and immunological testing
    • Y10S436/805Optical property
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00Chemistry: analytical and immunological testing
    • Y10S436/826Additives, e.g. buffers, diluents, preservatives
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/14Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333Saccharide [e.g., DNA, etc.]
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/25Chemistry: analytical and immunological testing including sample preparation
AT95116199T 1994-10-28 1995-10-13 Zusammensetzungen und verfahren für die gleichzeitige detektion und quantifizierung von einer mehrheit spezifischer nuklein säure sequenzen ATE340866T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US33110794A 1994-10-28 1994-10-28

Publications (1)

Publication Number Publication Date
ATE340866T1 true ATE340866T1 (de) 2006-10-15

Family

ID=23292651

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95116199T ATE340866T1 (de) 1994-10-28 1995-10-13 Zusammensetzungen und verfahren für die gleichzeitige detektion und quantifizierung von einer mehrheit spezifischer nuklein säure sequenzen

Country Status (10)

Country Link
US (4) US5756709A (de)
EP (1) EP0709466B1 (de)
JP (1) JP3190348B2 (de)
KR (1) KR100276679B1 (de)
AT (1) ATE340866T1 (de)
AU (1) AU710884B2 (de)
CA (1) CA2201595C (de)
DE (1) DE69535240T2 (de)
ES (1) ES2271944T3 (de)
WO (1) WO1996013612A2 (de)

Families Citing this family (226)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5714380A (en) 1986-10-23 1998-02-03 Amoco Corporation Closed vessel for isolating target molecules and for performing amplification
US5827727A (en) * 1990-02-01 1998-10-27 Emory University Method of resolution of 1,3-oxathiolane nucleoside enantiomers
EP0709466B1 (de) * 1994-10-28 2006-09-27 Gen-Probe Incorporated Zusammensetzungen und Verfahren für die gleichzeitige Detektion und Quantifizierung von einer Mehrheit spezifischer Nuklein Säure Sequenzen
WO1996041178A1 (en) * 1995-06-07 1996-12-19 Gen-Probe Incorporated Micelle protection assay
US5731148A (en) * 1995-06-07 1998-03-24 Gen-Probe Incorporated Adduct protection assay
US5879885A (en) * 1995-06-07 1999-03-09 Gen-Probe Incorporated Compositions for detecting and quantifying biological samples
DE19627290A1 (de) * 1996-07-06 1998-01-08 Boehringer Mannheim Gmbh Bestimmung von Analyten unter Verwendung zweier Markierungen
US5858665A (en) * 1996-07-25 1999-01-12 Navix, Inc. Homogeneous diagnostic assay method utilizing simultaneous target and signal amplification
WO1998045420A1 (en) * 1997-04-10 1998-10-15 Diagnocure Inc. Pca3, pca3 genes, and methods of use
US6534273B2 (en) 1997-05-02 2003-03-18 Gen-Probe Incorporated Two-step hybridization and capture of a polynucleotide
WO1998050583A1 (en) 1997-05-02 1998-11-12 Gen-Probe Incorporated Two-step hybridization and capture of a polynucleotide
WO1999000520A1 (en) * 1997-06-30 1999-01-07 The Government Of The United States Of America, Reresented By The Secretary Of The Department Of Health And Human Services Spectral cloning-a new technical approach to the cloning and characterization of every chromosomal aberration in cancer samples
US6180340B1 (en) * 1997-10-31 2001-01-30 Gen-Probe Incorporated Extended dynamic range assays
US6087102A (en) * 1998-01-07 2000-07-11 Clontech Laboratories, Inc. Polymeric arrays and methods for their use in binding assays
US6365346B1 (en) * 1998-02-18 2002-04-02 Dade Behring Inc. Quantitative determination of nucleic acid amplification products
US6703211B1 (en) 1998-03-13 2004-03-09 Promega Corporation Cellular detection by providing high energy phosphate donor other than ADP to produce ATP
US6312902B1 (en) 1998-03-13 2001-11-06 Promega Corporation Nucleic acid detection
US6235480B1 (en) 1998-03-13 2001-05-22 Promega Corporation Detection of nucleic acid hybrids
US6270974B1 (en) 1998-03-13 2001-08-07 Promega Corporation Exogenous nucleic acid detection
US6270973B1 (en) 1998-03-13 2001-08-07 Promega Corporation Multiplex method for nucleic acid detection
US6268146B1 (en) 1998-03-13 2001-07-31 Promega Corporation Analytical methods and materials for nucleic acid detection
US6391551B1 (en) 1998-03-13 2002-05-21 Promega Corporation Detection of nucleic acid hybrids
US7090975B2 (en) * 1998-03-13 2006-08-15 Promega Corporation Pyrophosphorolysis and incorporation of nucleotide method for nucleic acid detection
US6277578B1 (en) 1998-03-13 2001-08-21 Promega Corporation Deploymerization method for nucleic acid detection of an amplified nucleic acid target
US7244570B2 (en) * 1998-08-04 2007-07-17 Luminex Molecular Diagnostics, Inc. Methods and compositions for modulating “marginally indiscriminant” hybridizations
JP3562968B2 (ja) 1998-08-14 2004-09-08 富士写真フイルム株式会社 試験片、その製造方法および装置並びにその読取方法および装置
DE60043292D1 (de) 1999-02-12 2009-12-24 Gen Probe Inc Schutzsonden
PT1471926E (pt) 1999-06-01 2011-03-11 Baylor College Medicine Composições e métodos para a utilização terapêutica de uma sequência associada a atonal
AU5882000A (en) * 1999-06-22 2001-01-09 Invitrogen Corporation Improved primers and methods for the detection and discrimination of nucleic acids
US6623920B1 (en) * 1999-07-09 2003-09-23 Gen-Probe Incorporated Detection of HIV-1 by nucleic acid amplification
PT1222266E (pt) * 1999-09-29 2006-07-31 Diagnocure Inc Arn mensageiro de pca3 em tecidos benignos e malignos da prostata
GB2355791B (en) * 1999-10-28 2004-10-20 Molecular Light Tech Res Ltd Detection of mRNA expression using chemiluminescent labelled probes
GB2359625B (en) 1999-12-10 2004-10-20 Molecular Light Tech Res Ltd Monitoring oligonucleotide binding process using chemiluminescence quenching
FI20000333A0 (fi) * 2000-02-16 2000-02-16 Jussi Nurmi Homogeeninen menetelmä polynukleotidin havaitsemiseksi
EP1305632B1 (de) 2000-05-04 2011-07-27 Siemens Healthcare Diagnostics Products GmbH Verfahren zum nachweis von mehranalyten
EP1158057A1 (de) * 2000-05-18 2001-11-28 Centre National De La Recherche Scientifique Zusammenzetzungen und Verfahren geeignet für genetische Analyse
US6872523B1 (en) * 2000-05-30 2005-03-29 The Board Of Regents Of The University Of Nebraska Materials and methods for molecular detection of clinically relevant pathogenic fungal species
ATE414794T1 (de) * 2000-09-01 2008-12-15 Gen Probe Inc Amplifizierung von hiv-1 sequenzen zur detektion von sequenzen, die mit wirkstoff-resistenz mutationen einhergehen
US6582920B2 (en) 2000-09-01 2003-06-24 Gen-Probe Incorporated Amplification of HIV-1 RT sequences for detection of sequences associated with drug-resistance mutations
AU3054502A (en) * 2000-10-23 2002-05-06 Gen Probe Inc Compositions and methods for detecting human immunodeficiency virus 2 (hiv-2)
US20060073530A1 (en) * 2001-08-15 2006-04-06 Olaf Schneewind Methods and compositions involving sortase B
US20030165859A1 (en) 2001-10-23 2003-09-04 Invitrogen Corporation Primers and methods for the detection and discrimination of nucleic acids
ATE508188T1 (de) 2002-02-01 2011-05-15 Life Technologies Corp Oligonukleotid-zusammensetzungen mit verbesserter wirksamkeit
EP1572902B1 (de) 2002-02-01 2014-06-11 Life Technologies Corporation HOCHWIRKSAME siRNAS ZUR REDUZIERUNG DER EXPRESSION VON ZIELGENEN
US20060009409A1 (en) 2002-02-01 2006-01-12 Woolf Tod M Double-stranded oligonucleotides
US7560239B2 (en) * 2002-06-04 2009-07-14 Lin-Zhi International Inc. Homogeneous enzyme immunoassay for simultaneous detection of multiple analytes
AU2003253651C1 (en) 2002-06-14 2010-06-03 Gen-Probe Incorporated Compositions and methods for detecting hepatitis B virus
CN1754002B (zh) 2002-08-12 2010-09-08 杰能斯有限公司 涉及痘病毒和癌的组合物及制备方法
ATE553089T1 (de) * 2002-08-20 2012-04-15 Quest Diagnostics Invest Inc Hydrophile, chemilumineszente acridiniummarkierungsreagenzien
US6924154B2 (en) 2002-08-20 2005-08-02 Quest Diagnostics Investments Incorporated Hydrophilic chemilumescent acridinium labeling reagents
EP3241915B1 (de) 2002-10-16 2021-06-23 Gen-Probe Incorporated Zusammensetzungen und verfahren zum nachweis des west-nil-viruses
US20050282170A1 (en) 2003-02-07 2005-12-22 Diagnocure Inc. Method to detect prostate cancer in a sample
US20040265870A1 (en) * 2003-04-09 2004-12-30 Invitrogen Corporation Methods of synthesizing and labeling nucleic acid molecules
US20040241661A1 (en) * 2003-05-29 2004-12-02 Arindam Bhattacharjee Pseudo single color method for array assays
JP4699384B2 (ja) 2003-12-19 2011-06-08 ジェン−プロウブ インコーポレイテッド Hiv−1およびhiv−2の核酸を検出するための組成物、方法およびキット
AU2005218507A1 (en) * 2004-02-28 2005-09-15 Chang-Ning J. Wang Nucleic acid complexes
WO2005100538A1 (en) * 2004-04-16 2005-10-27 Spartan Bioscience Inc. System for rapid nucleic acid amplification and detection
WO2005111242A2 (en) * 2004-05-10 2005-11-24 Parallele Bioscience, Inc. Digital profiling of polynucleotide populations
EP2402465B1 (de) 2004-07-13 2014-11-19 Gen-Probe Incorporated Verfahren und Kit zur Detektion von Hepatitis-A-Virus-Nukleinsäure
WO2006031955A2 (en) 2004-09-14 2006-03-23 The Regents Of The University Of Colorado, A Body Corporate Method for treatment with bucindolol based on genetic targeting
US20060068380A1 (en) 2004-09-30 2006-03-30 Gen-Probe Incorporated Assay for detecting and quantifying HIV-1
CA2582661C (en) * 2004-11-09 2015-08-11 Gen-Probe Incorporated Compositions and methods for detecting group a streptococci
CA2491067A1 (en) * 2004-12-24 2006-06-24 Stichting Katholieke Universiteit Mrna rations in urinary sediments and/or urine as a prognostic marker for prostate cancer
US20060177859A1 (en) 2005-02-07 2006-08-10 Gen-Probe Incorporated Compositions and methods for detecting group B streptococci
AU2006214141B2 (en) 2005-02-18 2010-07-15 Gen-Probe Incorporated Sample preparation method incorporating an alkaline shock
CA2842232C (en) 2005-03-10 2015-01-27 Gen-Probe Incorporated Systems and methods to perform assays for detecting or quantifying analytes within samples
EP2348320B1 (de) 2005-03-10 2024-05-01 Gen-Probe Incorporated Verfahren und Systeme zur Erkennung mehrerer Fluoreszenzemissionssignale
CA2605015C (en) 2005-05-06 2013-09-10 Gen-Probe Incorporated Compositions and assays to detect influenza virus a and b nucleic acids
JP5187847B2 (ja) 2005-05-06 2013-04-24 ジェン−プローブ・インコーポレーテッド 核酸標的の捕獲方法
US20100015654A1 (en) * 2005-05-16 2010-01-21 Institut De Recherches Cliniques De Montreal/ I.R.C.M. Negative regulation of NK cell functions by EAT-2, a sap-related adaptor expressed in innate immune cells
JP2009507853A (ja) * 2005-09-07 2009-02-26 ジェンネレックス インコーポレイティッド Gm−csf発現ポックスウイルスを用いる転移性および/または全身播種性癌の全身処置
US8980246B2 (en) 2005-09-07 2015-03-17 Sillajen Biotherapeutics, Inc. Oncolytic vaccinia virus cancer therapy
EP1937847A2 (de) 2005-10-17 2008-07-02 Gen-Probe Incorporated Zusammensetzungen und verfahren zum nachweis von legionella pneumophila-nukleinsäure
US7537897B2 (en) * 2006-01-23 2009-05-26 Population Genetics Technologies, Ltd. Molecular counting
ATE514794T1 (de) * 2006-05-12 2011-07-15 Gen Probe Inc Zusammensetzungen und verfahren für den nachweis von enterokokken-nukleinsäuren
CA2658105C (en) 2006-08-01 2016-07-05 Gen-Probe Incorporated Methods of nonspecific target capture of nucleic acids
US8481023B2 (en) 2006-09-15 2013-07-09 Ottawa Hospital Research Institute Oncolytic rhabdovirus
US8119422B2 (en) * 2006-10-13 2012-02-21 Siemens Healthcare Diagnostics Inc. Stable acridinium esters with fast light emission
US7629125B2 (en) * 2006-11-16 2009-12-08 General Electric Company Sequential analysis of biological samples
US8305579B2 (en) 2006-11-16 2012-11-06 Thomas Pirrie Treynor Sequential analysis of biological samples
US9201063B2 (en) * 2006-11-16 2015-12-01 General Electric Company Sequential analysis of biological samples
EP2121956B1 (de) 2006-12-21 2016-08-17 Gen-Probe Incorporated Verfahren und zusammensetzungen zur amplizierung von nukleinsäuren
GB0701253D0 (en) 2007-01-23 2007-02-28 Diagnostics For The Real World Nucleic acid amplification and testing
US8247171B2 (en) * 2007-02-01 2012-08-21 Abacus Diagnostica Oy Method for detection of presence of target polynucleotide in samples
EP1978111B1 (de) 2007-04-02 2013-03-27 Gen-Probe Incorporated Zusammensetzungen, Kits und zugehörige Verfahren zur Erkennung und/oder Überwachung von Pseudomonas aeruginosa
CA2691451C (en) 2007-06-21 2015-03-24 Sara H. Fan Instrument and receptacles for performing processes
CA2709519A1 (en) 2007-12-21 2009-07-09 Gen-Probe Incorporated Detection of antibiotic-resistant microorganisms
WO2009085704A2 (en) 2007-12-26 2009-07-09 Gen-Probe Incorporated Compositions and methods to detect candida albicans nucleic acid
EP3957754A1 (de) 2008-04-21 2022-02-23 Gen-Probe Incorporated Verfahren zur erkennung des chikungunya-virus
US8703421B2 (en) 2008-05-30 2014-04-22 Gen-Probe Incorporated Compositions, kits and related methods for the detection and/or monitoring of Salmonella
US8097412B2 (en) * 2008-07-12 2012-01-17 Biodiagnostics, Inc. DNA-based test for detection of annual and intermediate ryegrass
CA2638458A1 (en) * 2008-07-31 2010-01-31 Spartan Bioscience Inc. Thermal recycling by positioning relative to fixed-temperature source
AU2009335053B2 (en) 2008-12-30 2013-08-01 Gen-Probe Incorporated Compositions, kits and related methods for the detection and/or monitoring of Listeria
CA2750900C (en) 2009-01-30 2017-03-28 Gen-Probe Incorporated Systems and methods for detecting a signal and applying thermal energy to a signal transmission element
EP3118208A1 (de) 2009-02-26 2017-01-18 Gen-Probe Incorporated Assay zum nachweisen menschlicher parvovirennukleinsäure
JP5785942B2 (ja) 2009-06-29 2015-09-30 ルミネックス コーポレーション ヘアピンコンフォメーションを有するキメラプライマーおよびその使用法
US9169512B2 (en) 2009-07-01 2015-10-27 Gen-Probe Incorporated Methods and compositions for nucleic acid amplification
US8628924B2 (en) 2009-07-21 2014-01-14 Gen-Probe Incorporated Methods and compositions for quantitative amplification and detection over a wide dynamic range
US9409983B2 (en) 2009-07-23 2016-08-09 The Board Of Trustess Of The University Of Illinois Methods and compositions involving PBEF inhibitors for lung inflammation conditions and diseases
WO2011032088A1 (en) 2009-09-11 2011-03-17 Arca Biopharma, Inc. Polymorphisms in the pde3a gene
EP3409119B1 (de) 2009-09-14 2020-08-12 SillaJen Biotherapeutics, Inc. Krebskombinationstherapie mit onkolytischem vaccinia virus
US9677125B2 (en) * 2009-10-21 2017-06-13 General Electric Company Detection of plurality of targets in biological samples
BR112012013664B1 (pt) 2009-12-10 2020-11-10 Turnstone Limited Partnership rabdovírus oncolítico
US9315857B2 (en) 2009-12-15 2016-04-19 Cellular Research, Inc. Digital counting of individual molecules by stochastic attachment of diverse label-tags
US8835358B2 (en) 2009-12-15 2014-09-16 Cellular Research, Inc. Digital counting of individual molecules by stochastic attachment of diverse labels
CA2822747A1 (en) 2009-12-23 2011-06-30 Arca Biopharma, Inc. Use of s-(6-nitro-oxi-hexahydro-furo[3,2-b]thioacetate in the treatment of cardiovascular disorders associated with oxide synthase dysfunction
WO2011103274A1 (en) 2010-02-17 2011-08-25 Gen-Probe Incorporated Compositions and methods to detect atopobium vaginae nucleic acid
EP3037555B1 (de) 2010-04-21 2019-07-24 Gen-Probe Incorporated Zusammensetzungen, verfahren und kits für den nachweis von herpes-simplex-virusnukleinsäuren
WO2012003289A1 (en) 2010-06-30 2012-01-05 Gen-Probe Incorporated Method and apparatus for identifying analyte-containing samples using single-read determination of analyte and process control signals
US9234249B2 (en) 2010-07-12 2016-01-12 Gen-Probe Incorporated Compositions and assays to detect swine H1N1 influenza A virus, seasonal H1 influenza A virus and seasonal H3 influenza A virus nucleic acids
EP2611932A2 (de) 2010-08-30 2013-07-10 Gen-Probe Incorporated Zusammensetzungen, verfahren und reaktionsmischungen für den nachweis von xenotropic murine leukemia virus-related virus (xmrv)
EP2616555B1 (de) 2010-09-16 2017-11-08 Gen-Probe Incorporated Über l-nukleotidenden immobilisierbare fängersonden
DK2623613T3 (en) 2010-09-21 2016-10-03 Population Genetics Tech Ltd Increasing the reliability of the allele-indications by molecular counting
EP3438289A1 (de) 2010-10-04 2019-02-06 Gen-Probe Prodesse, Inc. Zusammensetzungen, verfahren und kits für den nachweis von adenovirus-nukleinsäuren
CN103429258B (zh) 2011-01-04 2016-03-09 新罗杰公司 通过施用溶瘤痘苗病毒生成针对肿瘤抗原的抗体和生成肿瘤特异性补体依赖性细胞毒性
CA2828532A1 (en) 2011-02-28 2012-11-22 University Of Iowa Research Foundation Anti-mullerian hormone changes in pregnancy and prediction of adverse pregnancy outcomes and gender
WO2012120377A2 (en) 2011-03-08 2012-09-13 King Abdullah University Of Science And Technology Molecular biomarker set for early detection of ovarian cancer
EP2683833B1 (de) 2011-03-10 2018-09-26 Gen-Probe Incorporated Verfahren zur auswahl und optimierung von oligonukleotid-tagsequenzen
EP3272886B1 (de) 2011-04-25 2019-09-25 Gen-Probe Incorporated Zusammensetzungen und verfahren zum nachweis von bv-assoziierter bakterieller nukleinsäure
US9364532B2 (en) 2011-06-08 2016-06-14 Children's Hospital Of Eastern Ontario Research Institute Inc. Compositions and methods for glioblastoma treatment
AU2012284307A1 (en) 2011-07-15 2013-05-09 Gen-Probe Incorporated Compositions and method for detecting human parvovirus nucleic acid and for detecting hepatitis A virus nucleic acids in single-plex or multiplex assays
US9663829B2 (en) 2011-09-08 2017-05-30 Gen-Probe Incorporated Compositions and methods for detecting BV-associated bacterial nucleic acid
US10040853B2 (en) 2011-09-09 2018-08-07 Fred Hutchinson Cancer Research Center Methods and compositions involving NKG2D inhibitors and cancer
EP2758547B1 (de) 2011-09-21 2015-09-16 Gen-Probe Incorporated Verfahren zur amplifikation von nukleinsäuren unter verwendung von tag-vermittelter verschiebung
DE102011120550B4 (de) 2011-12-05 2013-11-07 Gen-Probe Prodesse, Inc. Zusammensetzungen, Verfahren und Kits zur Detektion von Adenovirusnukleinsäuren
EP2817416B1 (de) 2012-02-24 2018-10-31 Gen-Probe Prodesse Inc. Nachweis von shigatoxin-genen in bakterien
JP6375230B2 (ja) 2012-02-27 2018-08-15 セルラー リサーチ, インコーポレイテッド 分子計数のための組成物およびキット
ES2776673T3 (es) 2012-02-27 2020-07-31 Univ North Carolina Chapel Hill Métodos y usos para etiquetas moleculares
WO2013128281A1 (en) 2012-02-28 2013-09-06 Population Genetics Technologies Ltd Method for attaching a counter sequence to a nucleic acid sample
GB2561425B (en) 2012-03-16 2019-01-16 Cambridge Entpr Ltd Apparatus for obtaining liquid from a solid phase
AU2013205110B2 (en) 2012-04-24 2016-10-13 Gen-Probe Incorporated Compositions, Methods and Kits to Detect Herpes Simplex Virus Nucleic Acids
AU2013205064B2 (en) 2012-06-04 2015-07-30 Gen-Probe Incorporated Compositions and Methods for Amplifying and Characterizing HCV Nucleic Acid
ES2761920T3 (es) 2012-08-30 2020-05-21 Gen Probe Inc Amplificación de ácido nucleico multifásica
US10876152B2 (en) 2012-09-04 2020-12-29 Guardant Health, Inc. Systems and methods to detect rare mutations and copy number variation
US11913065B2 (en) 2012-09-04 2024-02-27 Guardent Health, Inc. Systems and methods to detect rare mutations and copy number variation
US20160040229A1 (en) 2013-08-16 2016-02-11 Guardant Health, Inc. Systems and methods to detect rare mutations and copy number variation
KR102028375B1 (ko) 2012-09-04 2019-10-04 가던트 헬쓰, 인크. 희귀 돌연변이 및 카피수 변이를 검출하기 위한 시스템 및 방법
AU2013205122B2 (en) 2012-10-11 2016-11-10 Gen-Probe Incorporated Compositions and Methods for Detecting Human Papillomavirus Nucleic Acid
AU2013205090B2 (en) 2012-12-07 2016-07-28 Gen-Probe Incorporated Compositions and Methods for Detecting Gastrointestinal Pathogen Nucleic Acid
WO2014116721A1 (en) 2013-01-22 2014-07-31 The Arizona Board Of Regents For And On Behalf Of Arizona State University Geminiviral vector for expression of rituximab
WO2014127478A1 (en) 2013-02-21 2014-08-28 Children's Hospital Of Eastern Ontario Research Institute Inc. Vaccine composition
WO2015023892A1 (en) 2013-08-14 2015-02-19 Gen-Probe Incorporated Compositions and methods for detecting hev nucleic acid
KR20230074639A (ko) 2013-08-28 2023-05-30 벡톤 디킨슨 앤드 컴퍼니 대량의 동시 단일 세포 분석
US20150098940A1 (en) 2013-10-03 2015-04-09 Oklahoma Medical Research Foundation Biomarkers for Systemic Lupus Erythematosus Disease Activity, and Intensity and Flare
US9582877B2 (en) 2013-10-07 2017-02-28 Cellular Research, Inc. Methods and systems for digitally counting features on arrays
AU2014369841B2 (en) 2013-12-28 2019-01-24 Guardant Health, Inc. Methods and systems for detecting genetic variants
DE102015220401B4 (de) 2014-10-20 2022-12-29 Gen-Probe Incorporated Erythrozyten-Lyselösung
WO2016086227A2 (en) 2014-11-26 2016-06-02 The Regents Of The University Of California Therapeutic compositions comprising transcription factors and methods of making and using the same
WO2016112252A1 (en) 2015-01-09 2016-07-14 Gen-Probe Incorporated Methods and compositions for diagnosing bacterial vaginosis
EP3259371B1 (de) 2015-02-19 2020-09-02 Becton, Dickinson and Company Hochdurchsatzeinzelzellenanalyse mit kombination von proteomischen und genomischen informationen
WO2016138496A1 (en) 2015-02-27 2016-09-01 Cellular Research, Inc. Spatially addressable molecular barcoding
US10550438B2 (en) 2015-03-16 2020-02-04 Gen-Probe Incorporated Methods and compositions for detecting bacterial nucleic acid
US11535882B2 (en) 2015-03-30 2022-12-27 Becton, Dickinson And Company Methods and compositions for combinatorial barcoding
CN107580632B (zh) 2015-04-23 2021-12-28 贝克顿迪金森公司 用于全转录组扩增的方法和组合物
WO2016196229A1 (en) 2015-06-01 2016-12-08 Cellular Research, Inc. Methods for rna quantification
JP6940484B2 (ja) 2015-09-11 2021-09-29 セルラー リサーチ, インコーポレイテッド ライブラリー正規化のための方法および組成物
EP3387107B1 (de) 2015-12-11 2020-08-12 Spartan Bioscience Inc. Röhrchenverschlusssystem und verfahren zur nukleinsäureamplifikation
SG11201805119QA (en) 2015-12-17 2018-07-30 Guardant Health Inc Methods to determine tumor gene copy number by analysis of cell-free dna
AU2017205399C1 (en) 2016-01-04 2023-06-15 Gen-Probe Incorporated Methods and compositions for detecting Candida species
AU2017214675B2 (en) 2016-02-05 2022-11-24 Gen-Probe Incorporated Dried amplification compositions
AU2017257978B2 (en) 2016-04-27 2022-12-22 Gen-Probe Incorporated Blood cell lysis reagent
JP7129343B2 (ja) 2016-05-02 2022-09-01 ベクトン・ディキンソン・アンド・カンパニー 正確な分子バーコーディング
US10301677B2 (en) 2016-05-25 2019-05-28 Cellular Research, Inc. Normalization of nucleic acid libraries
CN109074430B (zh) 2016-05-26 2022-03-29 贝克顿迪金森公司 分子标记计数调整方法
US10640763B2 (en) 2016-05-31 2020-05-05 Cellular Research, Inc. Molecular indexing of internal sequences
US10202641B2 (en) 2016-05-31 2019-02-12 Cellular Research, Inc. Error correction in amplification of samples
AU2017278065B2 (en) 2016-06-10 2020-09-10 Gen-Probe Incorporated Compositions and methods for detecting Zika virus nucleic acid
KR102363716B1 (ko) 2016-09-26 2022-02-18 셀룰러 리서치, 인크. 바코딩된 올리고뉴클레오티드 서열을 갖는 시약을 이용한 단백질 발현의 측정
CA3040907A1 (en) 2016-10-19 2018-04-26 Gen-Probe Incorporated Compositions and methods for detecting or quantifying hepatitis c virus
CN109952612B (zh) 2016-11-08 2023-12-01 贝克顿迪金森公司 用于表达谱分类的方法
CN117056774A (zh) 2016-11-08 2023-11-14 贝克顿迪金森公司 用于细胞标记分类的方法
JP7125395B2 (ja) 2016-11-21 2022-08-24 ジェン-プローブ・インコーポレーテッド B型肝炎ウイルスを検出または定量化するための組成物および方法
ES2961580T3 (es) 2017-01-13 2024-03-12 Cellular Res Inc Revestimiento hidrófilo de canales de fluidos
CN110462062A (zh) 2017-01-26 2019-11-15 俄克拉荷马医学研究基金会 系统性红斑狼疮疾病活动性、强度和急性发作的生物标志物
US11319583B2 (en) 2017-02-01 2022-05-03 Becton, Dickinson And Company Selective amplification using blocking oligonucleotides
EP4219771A3 (de) 2017-03-24 2023-08-16 Gen-Probe Incorporated Zusammensetzungen und verfahren für den multiplexnachweis viraler krankheitserreger in proben
WO2018175883A1 (en) 2017-03-24 2018-09-27 Gen-Probe Incorporated Compositions and methods for detecting or quantifying parainfluenza virus
WO2018183124A1 (en) 2017-03-25 2018-10-04 Gen-Probe Incorporated Compositions, methods and kits to detect adenovirus, metapneumovirus and/or rhinovirus nucleic acids
US20200165599A1 (en) 2017-05-11 2020-05-28 Gen-Probe Incorporated Compositions and Methods for Isolating Target Nucleic Acids
EP4345172A2 (de) 2017-06-05 2024-04-03 Becton, Dickinson and Company Probenindizierung für einzelzellen
WO2018226798A1 (en) 2017-06-07 2018-12-13 Gen-Probe Incorporated Detecting babesia species nucleic acid in a sample
CN111032209A (zh) 2017-07-10 2020-04-17 简·探针公司 分析系统和方法
WO2019032809A1 (en) 2017-08-11 2019-02-14 Gen-Probe Incorporated COMPOSITIONS AND METHODS FOR DETECTING STAPHYLOCOCCUS AUREUS
CA3082909C (en) 2017-11-17 2023-07-25 Gen-Probe Incorporated Compositions and methods for detecting c1orf43 nucleic acid
US20200318171A1 (en) 2017-12-15 2020-10-08 Gen-Probe Incorporated Compositions and Methods for Detecting Toxigenic Clostridium Difficile
WO2019126209A1 (en) 2017-12-19 2019-06-27 Cellular Research, Inc. Particles associated with oligonucleotides
US20210071242A1 (en) 2018-01-29 2021-03-11 Gen-Probe Incorporated Analytical systems and methods
US11365409B2 (en) 2018-05-03 2022-06-21 Becton, Dickinson And Company Molecular barcoding on opposite transcript ends
CN112272710A (zh) 2018-05-03 2021-01-26 贝克顿迪金森公司 高通量多组学样品分析
GB2597567B (en) 2018-06-13 2022-11-23 Gen Probe Inc Compositions and methods for detecting group B streptococcus nucleic acid
US20210317515A1 (en) 2018-07-10 2021-10-14 Gen-Probe Incorporated Methods and systems for detecting and quantifying nucleic acids
EP3830302B1 (de) 2018-08-01 2022-10-05 Gen-Probe Incorporated Zusammensetzungen und verfahren zum nachweis von nukleinsäuren des epstein-barr-virus
EP3841223A1 (de) 2018-08-08 2021-06-30 Gen-Probe Incorporated Zusammensetzungen, verfahren und kits zum nachweis von mycoplasma genitalium
AU2019326462A1 (en) 2018-08-21 2021-03-25 Gen-Probe Incorporated Compositions and methods for amplifying, detecting or quantifying human cytomegalovirus
CA3108906A1 (en) 2018-08-24 2020-02-27 Gen-Probe Incorporated Compositions and methods for detecting bacterial nucleic acid and diagnosing bacterial vaginosis
WO2020069085A2 (en) 2018-09-27 2020-04-02 Gen-Probe Incorporated Compositions and methods for detecting bordetella pertussis and bordetella parapertussis nucleic acid
EP3861134A1 (de) 2018-10-01 2021-08-11 Becton, Dickinson and Company Bestimmung von 5'-transkriptsequenzen
AU2019351824A1 (en) 2018-10-01 2021-05-27 Gen-Probe Incorporated Compositions and methods for amplifying or detecting varicella-zoster virus
EP3867645A4 (de) 2018-10-18 2022-07-13 Oklahoma Medical Research Foundation Biomarker für krankheitsaktivitätimmunindex von systemischem lupus erythematodes (sle) zur charakterisierung der krankheitsaktivität
JP2022508954A (ja) 2018-10-22 2022-01-19 ジェン-プローブ・インコーポレーテッド ヒトポリオーマウイルスbkウイルスを増幅、検出または定量化するための組成物および方法
JP2022509018A (ja) 2018-10-31 2022-01-20 アリゾナ ボード オブ リージェンツ オン ビハーフ オブ ザ ユニバーシティー オブ アリゾナ 放射線誘発肺障害のためのバイオマーカー及び使用方法
US11932849B2 (en) 2018-11-08 2024-03-19 Becton, Dickinson And Company Whole transcriptome analysis of single cells using random priming
WO2020123384A1 (en) 2018-12-13 2020-06-18 Cellular Research, Inc. Selective extension in single cell whole transcriptome analysis
TW202030333A (zh) 2018-12-20 2020-08-16 美商簡 探針公司 用於檢測瘧原蟲物種核酸之組成物及方法
WO2020150356A1 (en) 2019-01-16 2020-07-23 Becton, Dickinson And Company Polymerase chain reaction normalization through primer titration
EP3914728B1 (de) 2019-01-23 2023-04-05 Becton, Dickinson and Company Mit antikörpern assoziierte oligonukleotide
US20220098647A1 (en) 2019-03-22 2022-03-31 Gen-Probe Incorporated Compositions and Methods for Detecting Group A Streptococcus
US11965208B2 (en) 2019-04-19 2024-04-23 Becton, Dickinson And Company Methods of associating phenotypical data and single cell sequencing data
CA3176696A1 (en) 2019-05-03 2020-11-12 Gen-Probe Incorporated Receptacle transport system for an analytical system
CN114096683A (zh) 2019-07-03 2022-02-25 简·探针公司 用于确定样品中阴道毛滴虫的存在的寡核苷酸
WO2021016239A1 (en) 2019-07-22 2021-01-28 Becton, Dickinson And Company Single cell chromatin immunoprecipitation sequencing assay
JP2022545277A (ja) 2019-08-20 2022-10-26 イージーアイ テック (シェン チェン) カンパニー, リミテッド 発光標識及び二次発光信号の光信号速度論に基づくポリヌクレオチドの配列決定方法
AU2020335996A1 (en) 2019-08-23 2022-03-31 Gen-Probe Incorporated Compositions, methods and kits for detecting Treponema pallidum
CA3153514A1 (en) 2019-09-05 2021-03-11 Gen-Probe Incorporated Detection of chlamydia trachomatis nucleic acid variants
CN114729350A (zh) 2019-11-08 2022-07-08 贝克顿迪金森公司 使用随机引发获得用于免疫组库测序的全长v(d)j信息
EP4058187A1 (de) 2019-11-14 2022-09-21 Gen-Probe Incorporated Zusammensetzungen und verfahren zum einfangen von zielnukleinsäuren
WO2021146207A1 (en) 2020-01-13 2021-07-22 Becton, Dickinson And Company Methods and compositions for quantitation of proteins and rna
WO2021178644A1 (en) 2020-03-04 2021-09-10 Gen-Probe Incorporated Compositions and methods for detecting sars-cov-2 nucleic acid
US20230220499A1 (en) 2020-05-07 2023-07-13 Grifols Diagnostic Solutions Inc. Methods and compositions for detecting sars-cov-2 nucleic acid
WO2021231779A1 (en) 2020-05-14 2021-11-18 Becton, Dickinson And Company Primers for immune repertoire profiling
US11932901B2 (en) 2020-07-13 2024-03-19 Becton, Dickinson And Company Target enrichment using nucleic acid probes for scRNAseq
CN116323440A (zh) 2020-10-21 2023-06-23 简·探针公司 流体容器管理系统
US11739443B2 (en) 2020-11-20 2023-08-29 Becton, Dickinson And Company Profiling of highly expressed and lowly expressed proteins
AU2022319876A1 (en) 2021-07-27 2024-01-18 Gen-Probe Incorporated Compositions and methods for detecting gastrointestinal pathogens
WO2023175434A1 (en) 2022-03-15 2023-09-21 Diagenode S.A. Detection of methylation status of a dna sample
WO2024054924A1 (en) 2022-09-08 2024-03-14 Gen-Probe Incorporated Method of detecting nucleic acid analytes using dual-specificity primers

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL6515469A (de) * 1965-01-22 1966-07-25
US4238195A (en) * 1979-01-18 1980-12-09 Miles Laboratories, Inc. Fluorescer-labeled specific binding assays
GB2112779B (en) * 1981-12-11 1986-10-15 Welsh Nat School Med Aryl acridinium esters as luminescent labelling materials
US4672028A (en) * 1984-05-23 1987-06-09 Icn Micromedic Systems, Inc. Compositions and method for simultaneous multiple array of analytes using radioisotope chelate labels
US4918000A (en) * 1985-09-27 1990-04-17 Walter Schubert Multi-color labeling of different antigens in a biological system
GB8607101D0 (en) * 1986-03-21 1986-04-30 Serono Diagnostics Ltd Immunoassay
US4806463A (en) * 1986-05-23 1989-02-21 Worcester Foundation For Experimental Biology Inhibition of HTLV-III by exogenous oligonucleotides
US4931223A (en) * 1986-07-24 1990-06-05 Tropix, Inc. Methods of using chemiluminescent 1,2-dioxetanes
AU616646B2 (en) * 1986-11-24 1991-11-07 Gen-Probe Incorporated Nucleic acid probes for detection and/or quantitation of non-viral organisms
DE3850273T2 (de) * 1987-03-02 1994-09-29 Gen Probe Inc Polykationische Träger zur Reinigung, Trennung und Hybridisierung von Nukleinsäure.
US4927769A (en) * 1987-07-08 1990-05-22 Ciba Corning Diagnostics Corp. Method for enhancement of chemiluminescence
US5283174A (en) * 1987-09-21 1994-02-01 Gen-Probe, Incorporated Homogenous protection assay
PT88550A (pt) * 1987-09-21 1989-07-31 Ml Tecnology Ventures Lp Processo para a preparacao de reagentes de ligacao nao nucleotidicos para sondas nucleotidicas
CA1339872C (en) * 1987-09-21 1998-05-19 Lyle John Arnold Jr. Homogeneous protection assay
US5185439A (en) * 1987-10-05 1993-02-09 Gen-Probe Incorporated Acridinium ester labelling and purification of nucleotide probes
US5030557A (en) * 1987-11-24 1991-07-09 Ml Technology Venture Means and method for enhancing nucleic acid hybridization
US5094939A (en) * 1988-07-19 1992-03-10 Fujirebio, Inc. Chemiluminescence assays using stabilized dioxetane derivatives
GB2233450B (en) * 1989-06-24 1993-06-30 Univ Wales Medicine Detecting or quantifing multiple analytes with luminescent reagents
EP0731175A3 (de) * 1989-07-11 2004-05-26 Gen-Probe Incorporated Oligonukleotid-Sonden für Nukleinsäure von HIV
JPH03247300A (ja) * 1990-02-23 1991-11-05 Chugai Pharmaceut Co Ltd ヒト白血球抗原の型判定法
US5401847A (en) * 1990-03-14 1995-03-28 Regents Of The University Of California DNA complexes with dyes designed for energy transfer as fluorescent markers
AU9146491A (en) * 1990-12-28 1992-08-17 Abbott Laboratories Simultaneous determination of multiple analytes using a time-resolved heterogeneous chemiluminescence assay
US5206179A (en) * 1991-03-25 1993-04-27 Abbott Laboratories Fluorescence polarization immunoassays for multiple analytes using sequential addition of tracers
US5216143A (en) * 1991-06-28 1993-06-01 Gen-Probe Products Company Nucleic acid probes to mycobacterium gordonae
US5424413A (en) * 1992-01-22 1995-06-13 Gen-Probe Incorporated Branched nucleic acid probes
AU668746B2 (en) * 1992-06-12 1996-05-16 Gen-Probe Incorporated Preparation of nucleic acid from blood
ES2176229T3 (es) * 1993-03-19 2002-12-01 Novartis Ag Compuestos quimioluminiscentes de longitud de onda de emision larga y su uso en ensayos de prueba.
US5415503A (en) * 1994-05-02 1995-05-16 Jancy Engineering Company Portable drilling machine with internal motor control cord
EP0709466B1 (de) * 1994-10-28 2006-09-27 Gen-Probe Incorporated Zusammensetzungen und Verfahren für die gleichzeitige Detektion und Quantifizierung von einer Mehrheit spezifischer Nuklein Säure Sequenzen

Also Published As

Publication number Publication date
US5840873A (en) 1998-11-24
DE69535240D1 (de) 2006-11-09
DE69535240T2 (de) 2007-06-06
AU710884B2 (en) 1999-09-30
WO1996013612A3 (en) 1996-07-11
CA2201595C (en) 2003-08-19
EP0709466A3 (de) 1996-06-12
KR100276679B1 (ko) 2001-01-15
US5827656A (en) 1998-10-27
JPH10507351A (ja) 1998-07-21
EP0709466A2 (de) 1996-05-01
JP3190348B2 (ja) 2001-07-23
EP0709466B1 (de) 2006-09-27
CA2201595A1 (en) 1996-05-09
US5756709A (en) 1998-05-26
WO1996013612A2 (en) 1996-05-09
ES2271944T3 (es) 2007-04-16
US5658737A (en) 1997-08-19
AU4135696A (en) 1996-05-23
KR970707299A (ko) 1997-12-01

Similar Documents

Publication Publication Date Title
ATE340866T1 (de) Zusammensetzungen und verfahren für die gleichzeitige detektion und quantifizierung von einer mehrheit spezifischer nuklein säure sequenzen
FI900602A0 (fi) Bestaemning.
DE3785865D1 (de) Schnellverfahren zum nachweis von nukleinsaeure-sequenzen in einer probe mittels probemarkierung.
EP1448581A4 (de) Verfahren zum nachweis und zur quantifizierung von analyten in komplexen mischungen
DE3480487D1 (en) Nucleic acid hybridization assay
ATE206764T1 (de) Verfahren zum sensitiven nachweis von nukleinsäuren
DE69233630D1 (de) Sätze von HIV Sonden für Solution Sandwich Hybridationsverfahren
ATE285479T1 (de) Template abhängige ligierung mit pna-dna chimerischen sonden
ES543660A0 (es) Un metodo para determinar una secuencia particular de poli- nucleotidos en un medio de ensayo que contiene acidos nu- cleicos monocatenarios
DK0975800T3 (da) Analyse af nukleotider i opløsning under anvendelse af PNA-prober
ATE133714T1 (de) Polynukleotid-bestimmung mit selektierbaren spaltstellen
ATE78301T1 (de) Molekulare genetische sonde und verfahren zu ihrer herstellung, testmethode und satz in denen diese molekulare genetische sonde gebraucht wird.
ATE253127T1 (de) Sonde zur anwendung in der analyse von nukleinsaüren und verfahren der detektion basierend auf excimer-fluoreszenz
ATE90971T1 (de) Methode zur analyse einer spezifischen sequenz von dns oder rns, reagenzien und kits dafuer.
DE60119902D1 (de) Verfahren für die gleichzeitige und mehrfache detektion und quantifizierung der hybridisierung von molekülverbindungen wie nukleinsäuren, dns, rns, pns und proteinen
DE3567908D1 (en) Photoimmune detection of dna and rna

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 0709466

Country of ref document: EP

REN Ceased due to non-payment of the annual fee