DE69535240D1 - Zusammensetzungen und Verfahren für die gleichzeitige Detektion und Quantifizierung von einer Mehrheit spezifischer Nuklein Säure Sequenzen - Google Patents

Zusammensetzungen und Verfahren für die gleichzeitige Detektion und Quantifizierung von einer Mehrheit spezifischer Nuklein Säure Sequenzen

Info

Publication number
DE69535240D1
DE69535240D1 DE69535240T DE69535240T DE69535240D1 DE 69535240 D1 DE69535240 D1 DE 69535240D1 DE 69535240 T DE69535240 T DE 69535240T DE 69535240 T DE69535240 T DE 69535240T DE 69535240 D1 DE69535240 D1 DE 69535240D1
Authority
DE
Germany
Prior art keywords
methods
nucleic acid
quantification
majority
compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69535240T
Other languages
English (en)
Other versions
DE69535240T2 (de
Inventor
Norman C Nelson
James S Woodhead
Ian Weeks
Azzouz Ben Cheikh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gen Probe Inc
Original Assignee
Gen Probe Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gen Probe Inc filed Critical Gen Probe Inc
Publication of DE69535240D1 publication Critical patent/DE69535240D1/de
Application granted granted Critical
Publication of DE69535240T2 publication Critical patent/DE69535240T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D217/00Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D219/00Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6816Hybridisation assays characterised by the detection means
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00Chemistry: analytical and immunological testing
    • Y10S436/805Optical property
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00Chemistry: analytical and immunological testing
    • Y10S436/826Additives, e.g. buffers, diluents, preservatives
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/14Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333Saccharide [e.g., DNA, etc.]
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/25Chemistry: analytical and immunological testing including sample preparation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
DE69535240T 1994-10-28 1995-10-13 Zusammensetzungen und Verfahren für die gleichzeitige Detektion und Quantifizierung von einer Mehrheit spezifischer Nuklein Säure Sequenzen Expired - Lifetime DE69535240T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33110794A 1994-10-28 1994-10-28
US331107 1994-10-28

Publications (2)

Publication Number Publication Date
DE69535240D1 true DE69535240D1 (de) 2006-11-09
DE69535240T2 DE69535240T2 (de) 2007-06-06

Family

ID=23292651

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69535240T Expired - Lifetime DE69535240T2 (de) 1994-10-28 1995-10-13 Zusammensetzungen und Verfahren für die gleichzeitige Detektion und Quantifizierung von einer Mehrheit spezifischer Nuklein Säure Sequenzen

Country Status (10)

Country Link
US (4) US5756709A (de)
EP (1) EP0709466B1 (de)
JP (1) JP3190348B2 (de)
KR (1) KR100276679B1 (de)
AT (1) ATE340866T1 (de)
AU (1) AU710884B2 (de)
CA (1) CA2201595C (de)
DE (1) DE69535240T2 (de)
ES (1) ES2271944T3 (de)
WO (1) WO1996013612A2 (de)

Families Citing this family (226)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5714380A (en) 1986-10-23 1998-02-03 Amoco Corporation Closed vessel for isolating target molecules and for performing amplification
US6069252A (en) * 1990-02-01 2000-05-30 Emory University Method of resolution and antiviral activity of 1,3-oxathiolane nucleoside enantiomers
ATE340866T1 (de) * 1994-10-28 2006-10-15 Gen Probe Inc Zusammensetzungen und verfahren für die gleichzeitige detektion und quantifizierung von einer mehrheit spezifischer nuklein säure sequenzen
JP4236281B2 (ja) * 1995-06-07 2009-03-11 ジェン−プローブ・インコーポレーテッド ミセル保護アッセイ
US5879885A (en) * 1995-06-07 1999-03-09 Gen-Probe Incorporated Compositions for detecting and quantifying biological samples
US5731148A (en) * 1995-06-07 1998-03-24 Gen-Probe Incorporated Adduct protection assay
DE19627290A1 (de) * 1996-07-06 1998-01-08 Boehringer Mannheim Gmbh Bestimmung von Analyten unter Verwendung zweier Markierungen
US5858665A (en) * 1996-07-25 1999-01-12 Navix, Inc. Homogeneous diagnostic assay method utilizing simultaneous target and signal amplification
WO1998045420A1 (en) 1997-04-10 1998-10-15 Diagnocure Inc. Pca3, pca3 genes, and methods of use
US6534273B2 (en) 1997-05-02 2003-03-18 Gen-Probe Incorporated Two-step hybridization and capture of a polynucleotide
DE69836012T2 (de) 1997-05-02 2007-04-05 Gen-Probe Inc., San Diego Zwei-schritt hybridisierung und einfang von einem polynukleotid
WO1999000520A1 (en) * 1997-06-30 1999-01-07 The Government Of The United States Of America, Reresented By The Secretary Of The Department Of Health And Human Services Spectral cloning-a new technical approach to the cloning and characterization of every chromosomal aberration in cancer samples
US6180340B1 (en) * 1997-10-31 2001-01-30 Gen-Probe Incorporated Extended dynamic range assays
US6087102A (en) * 1998-01-07 2000-07-11 Clontech Laboratories, Inc. Polymeric arrays and methods for their use in binding assays
US6365346B1 (en) * 1998-02-18 2002-04-02 Dade Behring Inc. Quantitative determination of nucleic acid amplification products
US6235480B1 (en) 1998-03-13 2001-05-22 Promega Corporation Detection of nucleic acid hybrids
US6270973B1 (en) 1998-03-13 2001-08-07 Promega Corporation Multiplex method for nucleic acid detection
US7090975B2 (en) * 1998-03-13 2006-08-15 Promega Corporation Pyrophosphorolysis and incorporation of nucleotide method for nucleic acid detection
US6312902B1 (en) 1998-03-13 2001-11-06 Promega Corporation Nucleic acid detection
US6268146B1 (en) 1998-03-13 2001-07-31 Promega Corporation Analytical methods and materials for nucleic acid detection
US6391551B1 (en) 1998-03-13 2002-05-21 Promega Corporation Detection of nucleic acid hybrids
US6270974B1 (en) 1998-03-13 2001-08-07 Promega Corporation Exogenous nucleic acid detection
US6703211B1 (en) 1998-03-13 2004-03-09 Promega Corporation Cellular detection by providing high energy phosphate donor other than ADP to produce ATP
US6277578B1 (en) 1998-03-13 2001-08-21 Promega Corporation Deploymerization method for nucleic acid detection of an amplified nucleic acid target
US7244570B2 (en) * 1998-08-04 2007-07-17 Luminex Molecular Diagnostics, Inc. Methods and compositions for modulating “marginally indiscriminant” hybridizations
JP3562968B2 (ja) 1998-08-14 2004-09-08 富士写真フイルム株式会社 試験片、その製造方法および装置並びにその読取方法および装置
JP4772966B2 (ja) 1999-02-12 2011-09-14 ジェン−プローブ・インコーポレーテッド 保護プローブ
CA2375106C (en) 1999-06-01 2014-08-19 Huda Y. Zoghbi Compositions and methods for the therapeutic use of an atonal-associated sequence for deafness, osteoarthritis, and abnormal cell proliferation
CA2377707A1 (en) 1999-06-22 2000-12-28 Invitrogen Corporation Improved primers and methods for the detection and discrimination of nucleic acids
WO2001004361A2 (en) 1999-07-09 2001-01-18 Gen-Probe Incorporated Detection of hiv-1 by nucleic acid amplification
AU7636400A (en) 1999-09-29 2001-04-30 Diagnocure Inc. Pca3 messenger rna species in benign and malignant prostate tissues
GB2355791B (en) * 1999-10-28 2004-10-20 Molecular Light Tech Res Ltd Detection of mRNA expression using chemiluminescent labelled probes
GB2359625B (en) * 1999-12-10 2004-10-20 Molecular Light Tech Res Ltd Monitoring oligonucleotide binding process using chemiluminescence quenching
FI20000333A0 (fi) * 2000-02-16 2000-02-16 Jussi Nurmi Homogeeninen menetelmä polynukleotidin havaitsemiseksi
JP4796259B2 (ja) * 2000-05-04 2011-10-19 シーメンス・ヘルスケア・ダイアグノスティックス・プロダクツ・ゲーエムベーハー 複数のアナライトの検出において使用するための組成物
EP1158057A1 (de) * 2000-05-18 2001-11-28 Centre National De La Recherche Scientifique Zusammenzetzungen und Verfahren geeignet für genetische Analyse
US6872523B1 (en) * 2000-05-30 2005-03-29 The Board Of Regents Of The University Of Nebraska Materials and methods for molecular detection of clinically relevant pathogenic fungal species
US6582920B2 (en) 2000-09-01 2003-06-24 Gen-Probe Incorporated Amplification of HIV-1 RT sequences for detection of sequences associated with drug-resistance mutations
ATE414794T1 (de) 2000-09-01 2008-12-15 Gen Probe Inc Amplifizierung von hiv-1 sequenzen zur detektion von sequenzen, die mit wirkstoff-resistenz mutationen einhergehen
AU2002230545B2 (en) * 2000-10-23 2006-09-21 Gen-Probe Incorporated Compositions and methods for detecting human immunodeficiency virus 2 (HIV-2)
US20060073530A1 (en) * 2001-08-15 2006-04-06 Olaf Schneewind Methods and compositions involving sortase B
US20030165859A1 (en) 2001-10-23 2003-09-04 Invitrogen Corporation Primers and methods for the detection and discrimination of nucleic acids
DE60337040D1 (de) 2002-02-01 2011-06-16 Life Technologies Corp Oligonukleotid-Zusammensetzungen mit verbesserter Wirksamkeit
EP1572902B1 (de) 2002-02-01 2014-06-11 Life Technologies Corporation HOCHWIRKSAME siRNAS ZUR REDUZIERUNG DER EXPRESSION VON ZIELGENEN
US20060009409A1 (en) 2002-02-01 2006-01-12 Woolf Tod M Double-stranded oligonucleotides
US7560239B2 (en) * 2002-06-04 2009-07-14 Lin-Zhi International Inc. Homogeneous enzyme immunoassay for simultaneous detection of multiple analytes
ES2370169T3 (es) 2002-06-14 2011-12-13 Gen-Probe Incorporated Composiciones y métodos para detectar el virus de la hepatitis b.
WO2004014314A2 (en) 2002-08-12 2004-02-19 David Kirn Methods and compositions concerning poxviruses and cancer
US6924154B2 (en) 2002-08-20 2005-08-02 Quest Diagnostics Investments Incorporated Hydrophilic chemilumescent acridinium labeling reagents
ATE553089T1 (de) * 2002-08-20 2012-04-15 Quest Diagnostics Invest Inc Hydrophile, chemilumineszente acridiniummarkierungsreagenzien
US7115374B2 (en) 2002-10-16 2006-10-03 Gen-Probe Incorporated Compositions and methods for detecting West Nile virus
AU2004209578A1 (en) 2003-02-07 2004-08-19 Diagnocure Inc. Method to detect prostate cancer in a sample
US20040265870A1 (en) * 2003-04-09 2004-12-30 Invitrogen Corporation Methods of synthesizing and labeling nucleic acid molecules
US20040241661A1 (en) * 2003-05-29 2004-12-02 Arindam Bhattacharjee Pseudo single color method for array assays
CA2547750C (en) 2003-12-19 2014-04-08 Gen-Probe Incorporated Compositions, methods and kits for detecting the nucleic acids of hiv-1 and hiv-2
US20050260624A1 (en) * 2004-02-28 2005-11-24 Wang Chang N J Novel nucleic acid complexes and detection thereof
WO2005100538A1 (en) 2004-04-16 2005-10-27 Spartan Bioscience Inc. System for rapid nucleic acid amplification and detection
WO2005111242A2 (en) * 2004-05-10 2005-11-24 Parallele Bioscience, Inc. Digital profiling of polynucleotide populations
EP2412830B1 (de) 2004-07-13 2014-11-19 Gen-Probe Incorporated Zusammensetzungen und Verfahren zur Detektion von Hepatitis-A-Virus-Nukleinsäure
ATE469245T1 (de) 2004-09-14 2010-06-15 Univ Colorado Auf genetischem targeting basierendes verfahren zur behandlung mit bucindolol
AU2005291899A1 (en) 2004-09-30 2006-04-13 Gen-Probe Incorporated Assay for detecting and quantifying HIV-1
AU2005333163B2 (en) * 2004-11-09 2011-06-16 Gen-Probe Incorporated Compositions and methods for detecting Group A streptococci
CA2491067A1 (en) 2004-12-24 2006-06-24 Stichting Katholieke Universiteit Mrna rations in urinary sediments and/or urine as a prognostic marker for prostate cancer
JP4874999B2 (ja) 2005-02-07 2012-02-15 ジェン−プローブ・インコーポレーテッド B群連鎖球菌属を検出するための組成物及び方法
DE602006019203D1 (de) * 2005-02-18 2011-02-10 Gen Probe Inc Probenherstellungsverfahren mit einem alkali-stoss
WO2006099255A2 (en) 2005-03-10 2006-09-21 Gen-Probe Incorporated Systems and methods to perform assays for detecting or quantifying analytes within samples
EP1921454B1 (de) 2005-03-10 2015-08-12 Gen-Probe Incorporated Systeme und Verfahren zur Durchführung von Tests zum Nachweis oder zur Quantifizierung von Analyten
ES2381279T3 (es) 2005-05-06 2012-05-24 Gen-Probe Incorporated Métodos y productos para la captura de ácido nucleico diana
WO2006121773A2 (en) 2005-05-06 2006-11-16 Gen-Probe Incorporated Compositions and assays to detect influenza virus a and b nucleic acids
WO2006122401A1 (en) * 2005-05-16 2006-11-23 Institut De Recherches Cliniques De Montreal/I.R.C.M. Negative regulation of nk cell functions by eat-2, a sap-related adaptor expressed in innate immune cells
KR101772375B1 (ko) * 2005-09-07 2017-08-29 신라젠(주) Gm-csf를 발현하는 폭스바이러스를 사용한 전이성 및/또는 전신 파종성 암의 전신 치료법
US8980246B2 (en) 2005-09-07 2015-03-17 Sillajen Biotherapeutics, Inc. Oncolytic vaccinia virus cancer therapy
EP1937847A2 (de) 2005-10-17 2008-07-02 Gen-Probe Incorporated Zusammensetzungen und verfahren zum nachweis von legionella pneumophila-nukleinsäure
US7537897B2 (en) * 2006-01-23 2009-05-26 Population Genetics Technologies, Ltd. Molecular counting
AU2007249286B2 (en) * 2006-05-12 2013-06-13 Gen-Probe Incorporated Compositions and methods to detect enterococci nucleic acid
CA2658105C (en) 2006-08-01 2016-07-05 Gen-Probe Incorporated Methods of nonspecific target capture of nucleic acids
CA2921048C (en) 2006-09-15 2018-06-05 Ottawa Hospital Research Institute Oncolytic rhabdovirus
EP2074101B1 (de) * 2006-10-13 2012-08-08 Siemens Healthcare Diagnostics Inc. Stabile acridiniumester mit schneller lichtemission
US9201063B2 (en) * 2006-11-16 2015-12-01 General Electric Company Sequential analysis of biological samples
US7629125B2 (en) 2006-11-16 2009-12-08 General Electric Company Sequential analysis of biological samples
US8305579B2 (en) 2006-11-16 2012-11-06 Thomas Pirrie Treynor Sequential analysis of biological samples
US8198027B2 (en) 2006-12-21 2012-06-12 Gen-Probe Incorporated Methods and compositions for nucleic acid amplification
GB0701253D0 (en) 2007-01-23 2007-02-28 Diagnostics For The Real World Nucleic acid amplification and testing
EP2126114B1 (de) * 2007-02-01 2016-09-28 Abacus Diagnostica OY Verfahren zum nachweis des vorliegens von zielpolynukleotid in proben
EP1978111B1 (de) 2007-04-02 2013-03-27 Gen-Probe Incorporated Zusammensetzungen, Kits und zugehörige Verfahren zur Erkennung und/oder Überwachung von Pseudomonas aeruginosa
EP2384432B1 (de) 2007-06-21 2016-12-28 Gen-Probe Incorporated Instrument und behälter zur durchführung von verfahren
WO2009086218A2 (en) 2007-12-21 2009-07-09 Gen-Probe Incorporated Detection of antibiotic-resistant microorganisms
WO2009085704A2 (en) * 2007-12-26 2009-07-09 Gen-Probe Incorporated Compositions and methods to detect candida albicans nucleic acid
EP2281070B1 (de) 2008-04-21 2015-01-21 Gen-Probe Incorporated Verfahren zum nachweis von chikungunya-virus
US8703421B2 (en) 2008-05-30 2014-04-22 Gen-Probe Incorporated Compositions, kits and related methods for the detection and/or monitoring of Salmonella
US8097412B2 (en) * 2008-07-12 2012-01-17 Biodiagnostics, Inc. DNA-based test for detection of annual and intermediate ryegrass
CA2638458A1 (en) * 2008-07-31 2010-01-31 Spartan Bioscience Inc. Thermal recycling by positioning relative to fixed-temperature source
EP2389449B1 (de) 2008-12-30 2015-02-18 Gen-Probe Incorporated Zusammensetzungen, kits und damit verbundene verfahren zum nachweis und/oder überwachen von listerien
JP5586631B2 (ja) 2009-01-30 2014-09-10 ジェン−プローブ・インコーポレーテッド 信号を検出し、信号伝送要素に熱エネルギーを加えるためのシステム及び方法
US8921039B2 (en) 2009-02-26 2014-12-30 Gen-Probe Incorporated Assay for detection of human parvovirus nucleic acid
JP5785942B2 (ja) 2009-06-29 2015-09-30 ルミネックス コーポレーション ヘアピンコンフォメーションを有するキメラプライマーおよびその使用法
CA2766391C (en) 2009-07-01 2021-04-20 Gen-Probe Incorporated Methods and compositions for multiplex nucleic acid amplification
JP5575239B2 (ja) 2009-07-21 2014-08-20 ジェン−プローブ・インコーポレーテッド 拡張されたダイナミックレンジにわたる核酸配列の定量的検出のための方法および組成物
US9409983B2 (en) 2009-07-23 2016-08-09 The Board Of Trustess Of The University Of Illinois Methods and compositions involving PBEF inhibitors for lung inflammation conditions and diseases
WO2011032088A1 (en) 2009-09-11 2011-03-17 Arca Biopharma, Inc. Polymorphisms in the pde3a gene
EP2477499B1 (de) 2009-09-14 2018-04-11 SillaJen Biotherapeutics, Inc. Krebstherapie mit einer kombination aus onkolytischen impfstoffen
US9677125B2 (en) * 2009-10-21 2017-06-13 General Electric Company Detection of plurality of targets in biological samples
WO2011070440A2 (en) 2009-12-10 2011-06-16 Ottawa Hospital Research Institute Oncolytic rhabdovirus
US8835358B2 (en) 2009-12-15 2014-09-16 Cellular Research, Inc. Digital counting of individual molecules by stochastic attachment of diverse labels
US9315857B2 (en) 2009-12-15 2016-04-19 Cellular Research, Inc. Digital counting of individual molecules by stochastic attachment of diverse label-tags
EP2515899B1 (de) 2009-12-23 2016-05-25 ARCA biopharma, Inc. Verfahren und zusammensetzungen für herz-kreislauf-erkrankungen und -leiden
EP3604558B1 (de) 2010-02-17 2022-10-12 Gen-Probe Incorporated Zusammensetzungen und verfahren zum nachweis von atopobium-vaginae-nukleinsäure
CA3074551C (en) 2010-04-21 2021-05-04 Gen-Probe Incorporated Compositions, methods and kits to detect herpes simplex virus nucleic acids
CN102985566B (zh) 2010-06-30 2015-06-17 简.探针公司 使用分析物和过程控制信号的单次读取确定而鉴定含分析物的样品的方法和设备
US9234249B2 (en) 2010-07-12 2016-01-12 Gen-Probe Incorporated Compositions and assays to detect swine H1N1 influenza A virus, seasonal H1 influenza A virus and seasonal H3 influenza A virus nucleic acids
WO2012030856A2 (en) 2010-08-30 2012-03-08 Gen-Probe Incorporated Compositions, methods and reaction mixtures for the detection of xenotropic murine leukemia virus-related virus
CA2811333C (en) 2010-09-16 2020-05-12 Gen-Probe Incorporated Capture probes immobilizable via l-nucleotide tail
EP3115468B1 (de) 2010-09-21 2018-07-25 Agilent Technologies, Inc. Erhöhung der verlässlichkeit von allel-aufrufen mit molekülzählung
WO2012046219A2 (en) 2010-10-04 2012-04-12 Gen-Probe Prodesse, Inc. Compositions, methods and kits to detect adenovirus nucleic acids
WO2012094386A1 (en) 2011-01-04 2012-07-12 Jennerex Inc. Generation of antibodies to tumor antigens and generation of tumor specific complement dependent cytotoxicity by administration of oncolytic vaccinia virus
US20140057295A1 (en) 2011-02-28 2014-02-27 Barbara J. Stegmann Anti-mullerian hormone changes in pregnancy and prediction of adverse pregnancy outcomes and gender
WO2012120377A2 (en) 2011-03-08 2012-09-13 King Abdullah University Of Science And Technology Molecular biomarker set for early detection of ovarian cancer
WO2012122571A1 (en) 2011-03-10 2012-09-13 Gen-Probe Incorporated Methods and compositions for the selection and optimization of oligonucleotide tag sequences
EP3604559A1 (de) 2011-04-25 2020-02-05 Gen-Probe Incorporated Zusammensetzungen und verfahren zum nachweis von bv-assoziierter bakterieller nukleinsäure
CA2872045A1 (en) 2011-06-08 2012-12-13 Children's Hospital Of Eastern Ontario Research Institute Inc. Compositions and methods for glioblastoma treatment
WO2013012708A1 (en) 2011-07-15 2013-01-24 Gen-Probe Incorporated Compositions and method for detecting human parvovirus nucleic acid and for detecting hepatitis a virus nucleic acids in single-plex or multiplex assays
AU2012304327B2 (en) 2011-09-08 2015-07-09 Gen-Probe Incorporated Compositions and methods for detecting BV-associated bacterial nucleic acid
US10040853B2 (en) 2011-09-09 2018-08-07 Fred Hutchinson Cancer Research Center Methods and compositions involving NKG2D inhibitors and cancer
EP2758547B1 (de) 2011-09-21 2015-09-16 Gen-Probe Incorporated Verfahren zur amplifikation von nukleinsäuren unter verwendung von tag-vermittelter verschiebung
DE102011120550B4 (de) 2011-12-05 2013-11-07 Gen-Probe Prodesse, Inc. Zusammensetzungen, Verfahren und Kits zur Detektion von Adenovirusnukleinsäuren
EP2817416B1 (de) 2012-02-24 2018-10-31 Gen-Probe Prodesse Inc. Nachweis von shigatoxin-genen in bakterien
ES2776673T3 (es) 2012-02-27 2020-07-31 Univ North Carolina Chapel Hill Métodos y usos para etiquetas moleculares
GB2513024B (en) 2012-02-27 2016-08-31 Cellular Res Inc A clonal amplification method
WO2013128281A1 (en) 2012-02-28 2013-09-06 Population Genetics Technologies Ltd Method for attaching a counter sequence to a nucleic acid sample
GB2561425B (en) 2012-03-16 2019-01-16 Cambridge Entpr Ltd Apparatus for obtaining liquid from a solid phase
AU2013205110B2 (en) 2012-04-24 2016-10-13 Gen-Probe Incorporated Compositions, Methods and Kits to Detect Herpes Simplex Virus Nucleic Acids
AU2013205064B2 (en) 2012-06-04 2015-07-30 Gen-Probe Incorporated Compositions and Methods for Amplifying and Characterizing HCV Nucleic Acid
US9139870B2 (en) 2012-08-30 2015-09-22 Gen-Probe Incorporated Multiphase nucleic acid amplification
US20160040229A1 (en) 2013-08-16 2016-02-11 Guardant Health, Inc. Systems and methods to detect rare mutations and copy number variation
US11913065B2 (en) 2012-09-04 2024-02-27 Guardent Health, Inc. Systems and methods to detect rare mutations and copy number variation
DE202013012824U1 (de) 2012-09-04 2020-03-10 Guardant Health, Inc. Systeme zum Erfassen von seltenen Mutationen und einer Kopienzahlvariation
US10876152B2 (en) 2012-09-04 2020-12-29 Guardant Health, Inc. Systems and methods to detect rare mutations and copy number variation
AU2013205122B2 (en) 2012-10-11 2016-11-10 Gen-Probe Incorporated Compositions and Methods for Detecting Human Papillomavirus Nucleic Acid
AU2013205090B2 (en) 2012-12-07 2016-07-28 Gen-Probe Incorporated Compositions and Methods for Detecting Gastrointestinal Pathogen Nucleic Acid
WO2014116721A1 (en) 2013-01-22 2014-07-31 The Arizona Board Of Regents For And On Behalf Of Arizona State University Geminiviral vector for expression of rituximab
RU2019107976A (ru) 2013-02-21 2019-08-23 Тёрнстоун Лимитед Партнершип Композиция вакцины
EP4299767A3 (de) 2013-08-14 2024-03-27 Gen-Probe Incorporated Zusammensetzungen und verfahren zur detektion von hev-nukleinsäure
GB2546833B (en) 2013-08-28 2018-04-18 Cellular Res Inc Microwell for single cell analysis comprising single cell and single bead oligonucleotide capture labels
EP3052193B1 (de) 2013-10-03 2018-01-31 Oklahoma Medical Research Foundation Biomarker für die krankheitsaktivität, die intensität und das auftreten von systemischem lupus erythematodes
JP2017504307A (ja) 2013-10-07 2017-02-09 セルラー リサーチ, インコーポレイテッド アレイ上のフィーチャーをデジタルカウントするための方法およびシステム
ES2822125T3 (es) 2013-12-28 2021-04-29 Guardant Health Inc Métodos y sistemas para detectar variantes genéticas
DE102015220401B4 (de) 2014-10-20 2022-12-29 Gen-Probe Incorporated Erythrozyten-Lyselösung
WO2016086227A2 (en) 2014-11-26 2016-06-02 The Regents Of The University Of California Therapeutic compositions comprising transcription factors and methods of making and using the same
EP3736346B1 (de) 2015-01-09 2023-12-20 Gen-Probe Incorporated Verfahren und zusammensetzungen zur diagnose von bakterieller vaginose
EP3766988B1 (de) 2015-02-19 2024-02-14 Becton, Dickinson and Company Hochdurchsatzeinzelzellenanalyse mit kombination von proteomischen und genomischen informationen
CN107208158B (zh) 2015-02-27 2022-01-28 贝克顿迪金森公司 空间上可寻址的分子条形编码
JP6796593B2 (ja) 2015-03-16 2020-12-09 ジェン−プローブ・インコーポレーテッド 細菌核酸を検出し細菌性膣炎を診断するための方法および組成物
WO2016160844A2 (en) 2015-03-30 2016-10-06 Cellular Research, Inc. Methods and compositions for combinatorial barcoding
EP3286326A1 (de) 2015-04-23 2018-02-28 Cellular Research, Inc. Verfahren und zusammensetzungen zur gesamttranskriptomamplifikation
US11124823B2 (en) 2015-06-01 2021-09-21 Becton, Dickinson And Company Methods for RNA quantification
US10619186B2 (en) 2015-09-11 2020-04-14 Cellular Research, Inc. Methods and compositions for library normalization
EP3387107B1 (de) 2015-12-11 2020-08-12 Spartan Bioscience Inc. Röhrchenverschlusssystem und verfahren zur nukleinsäureamplifikation
CN117174167A (zh) 2015-12-17 2023-12-05 夸登特健康公司 通过分析无细胞dna确定肿瘤基因拷贝数的方法
EP4249610A3 (de) 2016-01-04 2023-12-20 Gen-Probe Incorporated Verfahren und zusammensetzungen zum nachweis von candida-spezies
JP7015785B2 (ja) 2016-02-05 2022-02-15 ジェン-プローブ・インコーポレーテッド 乾燥増幅組成物
US11162091B2 (en) 2016-04-27 2021-11-02 Gen-Probe Incorporated Blood cell lysis reagent
AU2017261189B2 (en) 2016-05-02 2023-02-09 Becton, Dickinson And Company Accurate molecular barcoding
US10301677B2 (en) 2016-05-25 2019-05-28 Cellular Research, Inc. Normalization of nucleic acid libraries
JP7046007B2 (ja) 2016-05-26 2022-04-01 ベクトン・ディキンソン・アンド・カンパニー 分子標識カウントの調節方法
US10202641B2 (en) 2016-05-31 2019-02-12 Cellular Research, Inc. Error correction in amplification of samples
US10640763B2 (en) 2016-05-31 2020-05-05 Cellular Research, Inc. Molecular indexing of internal sequences
EP3469103B1 (de) 2016-06-10 2021-10-06 Gen-Probe Incorporated Zusammensetzungen und verfahren für den nachweis von zikavirus-nukleinsäure
JP7091348B2 (ja) 2016-09-26 2022-06-27 ベクトン・ディキンソン・アンド・カンパニー バーコード付きオリゴヌクレオチド配列を有する試薬を用いたタンパク質発現の測定
WO2018075633A2 (en) 2016-10-19 2018-04-26 Gen-Probe Incorporated Compositions and methods for detecting or quantifying hepatitis c virus
JP7232180B2 (ja) 2016-11-08 2023-03-02 ベクトン・ディキンソン・アンド・カンパニー 発現プロファイル分類の方法
CN117056774A (zh) 2016-11-08 2023-11-14 贝克顿迪金森公司 用于细胞标记分类的方法
WO2018094171A1 (en) 2016-11-21 2018-05-24 Gen-Probe Incorporated Compositions and methods for detecting or quantifying hepatitis b virus
JP7104048B2 (ja) 2017-01-13 2022-07-20 セルラー リサーチ, インコーポレイテッド 流体チャネルの親水性コーティング
US20190390278A1 (en) 2017-01-26 2019-12-26 Oklahoma Medical Research Foundation Biomarkers for systemic lupus erythematosus disease activity, and intensity and flare
EP3577232A1 (de) 2017-02-01 2019-12-11 Cellular Research, Inc. Selektive amplifikation unter verwendung von blockierenden oligonukleotiden
EP4219771A3 (de) 2017-03-24 2023-08-16 Gen-Probe Incorporated Zusammensetzungen und verfahren für den multiplexnachweis viraler krankheitserreger in proben
EP3601617B3 (de) 2017-03-24 2024-03-20 Gen-Probe Incorporated Zusammensetzungen und verfahren zum nachweis oder zur quantifizierung des parainfluenzavirus
CA3056135C (en) 2017-03-25 2024-02-20 Gen-Probe Incorporated Compositions, methods and kits to detect adenovirus nucleic acids
CN110612354A (zh) 2017-05-11 2019-12-24 简·探针公司 用于分离靶核酸的组合物和方法
EP3635135A1 (de) 2017-06-05 2020-04-15 Becton, Dickinson and Company Probenindizierung für einzelzellen
EP4276201A3 (de) 2017-06-07 2024-01-17 Gen-Probe Incorporated Nachweis von nukleinsäure der babesia-spezies in einer probe
WO2019014239A1 (en) 2017-07-10 2019-01-17 Gen-Probe Incorporated ANALYTICAL SYSTEMS AND METHODS FOR AMPLIFICATION OF NUCLEIC ACIDS USING SAMPLE ASSIGNMENT PARAMETERS
EP4219766A3 (de) 2017-08-11 2023-10-11 Gen-Probe Incorporated Zusammensetzungen und verfahren zum nachweis von staphylococcus aureus
EP3710595A1 (de) 2017-11-17 2020-09-23 Gen-Probe Incorporated Zusammensetzungen und verfahren zur detektion von c1orf43-nukleinsäure
WO2019118735A1 (en) 2017-12-15 2019-06-20 Gen-Probe Incorporated Compositions and methods for detecting toxigenic clostridium difficile
CN111492068A (zh) 2017-12-19 2020-08-04 贝克顿迪金森公司 与寡核苷酸相关联的颗粒
CN111902213B (zh) 2018-01-29 2022-12-06 简·探针公司 分析系统和方法
WO2019213237A1 (en) 2018-05-03 2019-11-07 Becton, Dickinson And Company Molecular barcoding on opposite transcript ends
ES2945191T3 (es) 2018-05-03 2023-06-29 Becton Dickinson Co Análisis de muestras multiómicas de alto rendimiento
GB2597567B (en) 2018-06-13 2022-11-23 Gen Probe Inc Compositions and methods for detecting group B streptococcus nucleic acid
EP3820616A1 (de) 2018-07-10 2021-05-19 Gen-Probe Incorporated Verfahren und systeme zur detektion und quantifizierung von nukleinsäuren
EP3830302B1 (de) 2018-08-01 2022-10-05 Gen-Probe Incorporated Zusammensetzungen und verfahren zum nachweis von nukleinsäuren des epstein-barr-virus
CA3108105A1 (en) 2018-08-08 2020-02-13 Gen-Probe Incorporated Compositions, methods and kits for detecting mycoplasma genitalium
AU2019326462A1 (en) 2018-08-21 2021-03-25 Gen-Probe Incorporated Compositions and methods for amplifying, detecting or quantifying human cytomegalovirus
WO2020041671A1 (en) 2018-08-24 2020-02-27 Gen-Probe Incorporated Compositions and methods for detecting bacterial nucleic acid and diagnosing bacterial vaginosis
CA3112651A1 (en) 2018-09-27 2020-04-02 Gen-Probe Incorporated Compositions and methods for detecting bordetella pertussis and bordetella parapertussis nucleic acid
EP3861134A1 (de) 2018-10-01 2021-08-11 Becton, Dickinson and Company Bestimmung von 5'-transkriptsequenzen
WO2020072409A1 (en) 2018-10-01 2020-04-09 Gen-Probe Incorporated Compositions and methods for amplifying or detecting varicella-zoster virus
AU2019360758A1 (en) 2018-10-18 2021-05-20 Oklahoma Medical Research Foundation Biomarkers for a systemic lupus erythematosus (SLE) disease activity immune index that characterizes disease activity
JP2022508954A (ja) 2018-10-22 2022-01-19 ジェン-プローブ・インコーポレーテッド ヒトポリオーマウイルスbkウイルスを増幅、検出または定量化するための組成物および方法
WO2020089841A1 (en) 2018-10-31 2020-05-07 Garcia Joe G N Biomarkers and methods of use for radiation-induced lung injury
WO2020097315A1 (en) 2018-11-08 2020-05-14 Cellular Research, Inc. Whole transcriptome analysis of single cells using random priming
WO2020123384A1 (en) 2018-12-13 2020-06-18 Cellular Research, Inc. Selective extension in single cell whole transcriptome analysis
TW202030333A (zh) 2018-12-20 2020-08-16 美商簡 探針公司 用於檢測瘧原蟲物種核酸之組成物及方法
WO2020150356A1 (en) 2019-01-16 2020-07-23 Becton, Dickinson And Company Polymerase chain reaction normalization through primer titration
ES2945227T3 (es) 2019-01-23 2023-06-29 Becton Dickinson Co Oligonucleótidos asociados con anticuerpos
US20220098647A1 (en) 2019-03-22 2022-03-31 Gen-Probe Incorporated Compositions and Methods for Detecting Group A Streptococcus
US11965208B2 (en) 2019-04-19 2024-04-23 Becton, Dickinson And Company Methods of associating phenotypical data and single cell sequencing data
CA3176703A1 (en) 2019-05-03 2020-11-12 Gen-Probe Incorporated Receptacle transport system for an analytical system
CN114096683A (zh) 2019-07-03 2022-02-25 简·探针公司 用于确定样品中阴道毛滴虫的存在的寡核苷酸
CN114051534A (zh) 2019-07-22 2022-02-15 贝克顿迪金森公司 单细胞染色质免疫沉淀测序测定
WO2021031109A1 (zh) 2019-08-20 2021-02-25 深圳华大智造极创科技有限公司 一种基于发光标记物光信号动力学及二次发光信号对多核苷酸进行测序的方法
CA3152309A1 (en) 2019-08-23 2021-03-04 Gen-Probe Incorporated Compositions, methods and kits for detecting treponema pallidum
JP2022553489A (ja) 2019-09-05 2022-12-23 ジェン-プローブ・インコーポレーテッド Chlamydia trachomatis変異体の核酸の検出
JP2023500679A (ja) 2019-11-08 2023-01-10 ベクトン・ディキンソン・アンド・カンパニー 免疫レパートリーシーケンシングのための完全長v(d)j情報を得るためのランダムプライミングの使用
AU2020384888A1 (en) 2019-11-14 2022-06-23 Gen-Probe Incorporated Compositions and methods for capturing target nucleic acids
CN115244184A (zh) 2020-01-13 2022-10-25 贝克顿迪金森公司 用于定量蛋白和rna的方法和组合物
JP2023516683A (ja) 2020-03-04 2023-04-20 ジェン-プローブ・インコーポレーテッド SARS-CoV-2核酸を検出するための組成物および方法
US20230220499A1 (en) 2020-05-07 2023-07-13 Grifols Diagnostic Solutions Inc. Methods and compositions for detecting sars-cov-2 nucleic acid
WO2021231779A1 (en) 2020-05-14 2021-11-18 Becton, Dickinson And Company Primers for immune repertoire profiling
US11932901B2 (en) 2020-07-13 2024-03-19 Becton, Dickinson And Company Target enrichment using nucleic acid probes for scRNAseq
CN116323440A (zh) 2020-10-21 2023-06-23 简·探针公司 流体容器管理系统
EP4247967A1 (de) 2020-11-20 2023-09-27 Becton, Dickinson and Company Profilierung von stark exprimierten und schwach exprimierten proteinen
WO2023010008A1 (en) 2021-07-27 2023-02-02 Gen-Probe Incorporated Compositions and methods for detecting gastrointestinal pathogens
WO2023175434A1 (en) 2022-03-15 2023-09-21 Diagenode S.A. Detection of methylation status of a dna sample
WO2024054924A1 (en) 2022-09-08 2024-03-14 Gen-Probe Incorporated Method of detecting nucleic acid analytes using dual-specificity primers

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL6515469A (de) * 1965-01-22 1966-07-25
US4238195A (en) * 1979-01-18 1980-12-09 Miles Laboratories, Inc. Fluorescer-labeled specific binding assays
EP0082636B2 (de) * 1981-12-11 2006-10-18 The Welsh National School of Medicine Lumineszierende Markierungssubstanzen und -verfahren
US4672028A (en) * 1984-05-23 1987-06-09 Icn Micromedic Systems, Inc. Compositions and method for simultaneous multiple array of analytes using radioisotope chelate labels
US4918000A (en) * 1985-09-27 1990-04-17 Walter Schubert Multi-color labeling of different antigens in a biological system
GB8607101D0 (en) * 1986-03-21 1986-04-30 Serono Diagnostics Ltd Immunoassay
US4806463A (en) * 1986-05-23 1989-02-21 Worcester Foundation For Experimental Biology Inhibition of HTLV-III by exogenous oligonucleotides
US4931223A (en) * 1986-07-24 1990-06-05 Tropix, Inc. Methods of using chemiluminescent 1,2-dioxetanes
DE3752172T3 (de) * 1986-11-24 2008-04-10 Gen-Probe Inc., San Diego Nukleinsäuresonden zum Nachweis und/oder zur Quantifizierung von nicht-viralen Organismen
WO1988006633A1 (en) * 1987-03-02 1988-09-07 Arnold Lyle John Jr Polycationic supports for nucleic acid purification, separation and hybridization
US4927769A (en) * 1987-07-08 1990-05-22 Ciba Corning Diagnostics Corp. Method for enhancement of chemiluminescence
JP3012244B2 (ja) * 1987-09-21 2000-02-21 ジェン―プローブ インコーポレイテッド ヌクレオチドプローブ用非ヌクレオチド連結試薬
EP0638807B1 (de) * 1987-09-21 2002-07-17 Gen-Probe Incorporated Schutztest
US5283174A (en) * 1987-09-21 1994-02-01 Gen-Probe, Incorporated Homogenous protection assay
US5185439A (en) * 1987-10-05 1993-02-09 Gen-Probe Incorporated Acridinium ester labelling and purification of nucleotide probes
US5030557A (en) * 1987-11-24 1991-07-09 Ml Technology Venture Means and method for enhancing nucleic acid hybridization
US5094939A (en) * 1988-07-19 1992-03-10 Fujirebio, Inc. Chemiluminescence assays using stabilized dioxetane derivatives
GB2233450B (en) * 1989-06-24 1993-06-30 Univ Wales Medicine Detecting or quantifing multiple analytes with luminescent reagents
EP0731174B1 (de) * 1989-07-11 2004-11-17 Gen-Probe Incorporated Verfahren zur Amplifikation von Nukleinsäuresequenzen
JPH03247300A (ja) * 1990-02-23 1991-11-05 Chugai Pharmaceut Co Ltd ヒト白血球抗原の型判定法
US5401847A (en) * 1990-03-14 1995-03-28 Regents Of The University Of California DNA complexes with dyes designed for energy transfer as fluorescent markers
WO1992012255A1 (en) * 1990-12-28 1992-07-23 Abbott Laboratories Simultaneous determination of multiple analytes using a time-resolved heterogeneous chemiluminescence assay
US5206179A (en) * 1991-03-25 1993-04-27 Abbott Laboratories Fluorescence polarization immunoassays for multiple analytes using sequential addition of tracers
US5216143A (en) * 1991-06-28 1993-06-01 Gen-Probe Products Company Nucleic acid probes to mycobacterium gordonae
US5424413A (en) * 1992-01-22 1995-06-13 Gen-Probe Incorporated Branched nucleic acid probes
EP0574267A3 (en) * 1992-06-12 1994-08-24 Gen Probe Inc Preparation of nucleic acid from blood
EP0617288B1 (de) * 1993-03-19 2002-05-02 Novartis AG Chemilumineszierende Derivate mit langer Emissionswellenlänge und ihre Verwendung in Assays
US5415503A (en) * 1994-05-02 1995-05-16 Jancy Engineering Company Portable drilling machine with internal motor control cord
ATE340866T1 (de) * 1994-10-28 2006-10-15 Gen Probe Inc Zusammensetzungen und verfahren für die gleichzeitige detektion und quantifizierung von einer mehrheit spezifischer nuklein säure sequenzen

Also Published As

Publication number Publication date
US5840873A (en) 1998-11-24
KR100276679B1 (ko) 2001-01-15
JPH10507351A (ja) 1998-07-21
CA2201595C (en) 2003-08-19
US5658737A (en) 1997-08-19
AU4135696A (en) 1996-05-23
EP0709466A3 (de) 1996-06-12
CA2201595A1 (en) 1996-05-09
DE69535240T2 (de) 2007-06-06
US5827656A (en) 1998-10-27
ATE340866T1 (de) 2006-10-15
KR970707299A (ko) 1997-12-01
AU710884B2 (en) 1999-09-30
EP0709466B1 (de) 2006-09-27
JP3190348B2 (ja) 2001-07-23
EP0709466A2 (de) 1996-05-01
US5756709A (en) 1998-05-26
ES2271944T3 (es) 2007-04-16
WO1996013612A2 (en) 1996-05-09
WO1996013612A3 (en) 1996-07-11

Similar Documents

Publication Publication Date Title
DE69535240D1 (de) Zusammensetzungen und Verfahren für die gleichzeitige Detektion und Quantifizierung von einer Mehrheit spezifischer Nuklein Säure Sequenzen
FI900602A0 (fi) Bestaemning.
EP1448581A4 (de) Verfahren zum nachweis und zur quantifizierung von analyten in komplexen mischungen
DE3785865D1 (de) Schnellverfahren zum nachweis von nukleinsaeure-sequenzen in einer probe mittels probemarkierung.
ES543660A0 (es) Un metodo para determinar una secuencia particular de poli- nucleotidos en un medio de ensayo que contiene acidos nu- cleicos monocatenarios
DE69233630D1 (de) Sätze von HIV Sonden für Solution Sandwich Hybridationsverfahren
ATE174968T1 (de) Verfahren mit einem gen-sonden biosensor
DK0975800T3 (da) Analyse af nukleotider i opløsning under anvendelse af PNA-prober
AU1010688A (en) Diagnostic assays using nucleic acid probes
ATE133714T1 (de) Polynukleotid-bestimmung mit selektierbaren spaltstellen
DE60219813D1 (de) Test-streife-probesystem und verfahren zur nachweis von spezifischen nukleinsäuresequenzen
ATE78301T1 (de) Molekulare genetische sonde und verfahren zu ihrer herstellung, testmethode und satz in denen diese molekulare genetische sonde gebraucht wird.
CA2349810C (en) Isometric primer extension method and kit for detection and quantification of specific nucleic acid
DE69630517D1 (de) Sonde zur anwendung in der analyse von nukleinsaüren und verfahren der detektion basierend auf excimer-fluoreszenz
ATE90971T1 (de) Methode zur analyse einer spezifischen sequenz von dns oder rns, reagenzien und kits dafuer.
DE60119902D1 (de) Verfahren für die gleichzeitige und mehrfache detektion und quantifizierung der hybridisierung von molekülverbindungen wie nukleinsäuren, dns, rns, pns und proteinen
DE3567908D1 (en) Photoimmune detection of dna and rna

Legal Events

Date Code Title Description
8364 No opposition during term of opposition