ATE244259T1 - Verwendungen von fluoreszierenden n-nukleosiden und dessen analogen - Google Patents

Verwendungen von fluoreszierenden n-nukleosiden und dessen analogen

Info

Publication number
ATE244259T1
ATE244259T1 AT93905954T AT93905954T ATE244259T1 AT E244259 T1 ATE244259 T1 AT E244259T1 AT 93905954 T AT93905954 T AT 93905954T AT 93905954 T AT93905954 T AT 93905954T AT E244259 T1 ATE244259 T1 AT E244259T1
Authority
AT
Austria
Prior art keywords
fluorescent
methods
rna
dna
sequences
Prior art date
Application number
AT93905954T
Other languages
English (en)
Inventor
Michael J Conrad
Original Assignee
Chromagen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25266988&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE244259(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Chromagen Inc filed Critical Chromagen Inc
Application granted granted Critical
Publication of ATE244259T1 publication Critical patent/ATE244259T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6832—Enhancement of hybridisation reaction

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
AT93905954T 1992-02-12 1993-02-12 Verwendungen von fluoreszierenden n-nukleosiden und dessen analogen ATE244259T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US83445692A 1992-02-12 1992-02-12
PCT/US1993/001338 WO1993016094A2 (en) 1992-02-12 1993-02-12 Applications of fluorescent n-nucleosides and fluorescent structural analogs of n-nucleosides

Publications (1)

Publication Number Publication Date
ATE244259T1 true ATE244259T1 (de) 2003-07-15

Family

ID=25266988

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93905954T ATE244259T1 (de) 1992-02-12 1993-02-12 Verwendungen von fluoreszierenden n-nukleosiden und dessen analogen

Country Status (7)

Country Link
US (1) US5763167A (de)
EP (1) EP0628051B1 (de)
JP (1) JPH07504087A (de)
AT (1) ATE244259T1 (de)
CA (1) CA2129105A1 (de)
DE (1) DE69333073T2 (de)
WO (1) WO1993016094A2 (de)

Families Citing this family (104)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5571388A (en) * 1984-03-29 1996-11-05 Li-Cor, Inc. Sequencing near infrared and infrared fluorescense labeled DNA for detecting using laser diodes and suitable labels thereof
US6207421B1 (en) 1984-03-29 2001-03-27 Li-Cor, Inc. DNA sequencing and DNA terminators
US6086737A (en) * 1984-03-29 2000-07-11 Li-Cor, Inc. Sequencing near infrared and infrared fluorescence labeled DNA for detecting using laser diodes and suitable labels therefor
US5863403A (en) * 1984-03-29 1999-01-26 The Board Of Regents Of The University Of Nebraska Digital DNA typing
US6004446A (en) * 1984-03-29 1999-12-21 Li-Cor, Inc. DNA Sequencing
US5652099A (en) 1992-02-12 1997-07-29 Conrad; Michael J. Probes comprising fluorescent nucleosides and uses thereof
EP0628051B1 (de) * 1992-02-12 2003-07-02 Chromagen, Inc. Verwendungen von fluoreszierenden n-nukleosiden und dessen analogen
WO1995005391A1 (en) * 1993-08-18 1995-02-23 Chromagen, Inc. Applications of fluorescent n-nucleosides and fluorescent structural analogs of n-nucleosides
US5601978A (en) * 1993-09-03 1997-02-11 Abbott Laboratories Oligonucleotides and methods for the detection of chlamydia trachomatis
US5525711A (en) * 1994-05-18 1996-06-11 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Pteridine nucleotide analogs as fluorescent DNA probes
DE19509038A1 (de) * 1995-03-14 1996-09-19 Boehringer Mannheim Gmbh C-Nukleosid-Derivate und deren Verwendung in der Detektion von Nukleinsäuren
US6342379B1 (en) * 1995-06-07 2002-01-29 The Regents Of The University Of California Detection of transmembrane potentials by optical methods
US6596522B2 (en) * 1997-05-08 2003-07-22 The Regents Of The University Of California Detection of transmembrane potentials by optical methods
US6864059B2 (en) 1996-01-23 2005-03-08 Affymetrix, Inc. Biotin containing C-glycoside nucleic acid labeling compounds
US20010018514A1 (en) 1998-07-31 2001-08-30 Mcgall Glenn H. Nucleic acid labeling compounds
US7423143B2 (en) 1996-01-23 2008-09-09 Affymetrix. Inc. Nucleic acid labeling compounds
US6965020B2 (en) 1996-01-23 2005-11-15 Affymetrix, Inc. Nucleic acid labeling compounds
US7291463B2 (en) 1996-01-23 2007-11-06 Affymetrix, Inc. Nucleic acid labeling compounds
US7282327B2 (en) 1996-01-23 2007-10-16 Affymetrix, Inc. Nucleic acid labeling compounds
US6372480B1 (en) 1996-04-19 2002-04-16 Mycogen Corporation Pesticidal proteins
DE19637042A1 (de) * 1996-09-12 1998-03-19 Boehringer Mannheim Gmbh Heterocyclische Verbindungen und deren Verwendung in der Detektion von Nucleinsäuren
US6242669B1 (en) 1996-10-30 2001-06-05 Mycogen Corporation Pesticidal toxins and nucleotide sequences which encode these toxins
US6485901B1 (en) 1997-10-27 2002-11-26 Boston Probes, Inc. Methods, kits and compositions pertaining to linear beacons
AU1366299A (en) 1997-10-27 1999-05-17 Boston Probes, Inc. Methods, kits and compositions pertaining to pna molecular beacons
US6361942B1 (en) 1998-03-24 2002-03-26 Boston Probes, Inc. Method, kits and compositions pertaining to detection complexes
FR2780059B1 (fr) * 1998-06-17 2002-10-11 Bio Merieux Procede de marquage d'un acide ribonucleique et fragments d'arn marques ainsi obtenus
GB9923144D0 (en) * 1999-09-30 1999-12-01 Socrates Biotech International Methods
WO2001038585A2 (en) * 1999-11-24 2001-05-31 The Regents Of The University Of California Polymer arrays and methods of using labeled probe molecules to identify and quantify target molecule expression
US6902891B2 (en) 1999-12-17 2005-06-07 Bio Merieux Process for labeling a nucleic acid
US6489114B2 (en) 1999-12-17 2002-12-03 Bio Merieux Process for labeling a ribonucleic acid, and labeled RNA fragments which are obtained thereby
US6844154B2 (en) 2000-04-04 2005-01-18 Polygenyx, Inc. High throughput methods for haplotyping
AU2001278517A1 (en) 2000-08-03 2002-02-18 F. Hoffman-La Roche Ag Nucleic acid binding compounds containing pyrazolo(3,4-d)pyrimidine analogues of purin-2,6-diamine and their uses
CA2440615A1 (en) 2001-03-12 2002-09-19 Affymetrix, Inc. Nucleic acid labeling compounds
US7338805B2 (en) 2001-05-04 2008-03-04 Bio Merieux Labeling reagents, methods for synthesizing such reagents and methods for detecting biological molecules
US7060441B2 (en) 2001-05-04 2006-06-13 Biomerieux Method for fragmenting and labeling DNA involving abasic sites and phosphate labeling
US6887690B2 (en) 2001-06-22 2005-05-03 Pe Corporation Dye-labeled ribonucleotide triphosphates
US20060009409A1 (en) 2002-02-01 2006-01-12 Woolf Tod M Double-stranded oligonucleotides
WO2003064625A2 (en) 2002-02-01 2003-08-07 Sequitur, Inc. Oligonucleotide compositions with enhanced efficiency
US20030166282A1 (en) 2002-02-01 2003-09-04 David Brown High potency siRNAS for reducing the expression of target genes
US20100075423A1 (en) * 2002-06-12 2010-03-25 Life Technologies Corporation Methods and compositions relating to polypeptides with rnase iii domains that mediate rna interference
US20040110184A1 (en) 2002-06-28 2004-06-10 Dow Agrosciences Llc Pesticidally active proteins and polynucleotides obtainable from Paenibacillus species
WO2004028481A2 (en) * 2002-09-30 2004-04-08 Genelabs Technologies, Inc. Nucleoside derivatives for treating hepatitis c virus infection
US7094768B2 (en) * 2002-09-30 2006-08-22 Genelabs Technologies, Inc. Nucleoside derivatives for treating hepatitis C virus infection
WO2004063339A2 (en) 2003-01-08 2004-07-29 Lesley Davenport G-quadruplex binding assays and compounds therefor
US7169918B2 (en) * 2003-10-27 2007-01-30 Genelabs Technologies, Inc. Methods for preparing 7-(2′-substituted-β-D-ribofuranosyl)-4-(NR2R3)-5-(substituted ethyn-1-yl)-pyrrolo[2,3-d]pyrimidine derivatives
JP4127204B2 (ja) * 2003-12-17 2008-07-30 セイコーエプソン株式会社 液晶表示装置の製造方法
DE102004009977A1 (de) * 2004-03-01 2005-09-22 Chembiotech Gmbh Fluoreszierende Ethenonucleoside und Oligonucleotide mit hoher Stabilität
FR2868071B1 (fr) 2004-03-26 2006-06-09 Biomerieux Sa Reactifs de marquage, procedes de synthese de tels reactifs et procedes de detection de molecules biologiques
EP2308977B2 (de) 2004-04-30 2017-04-26 Dow AgroSciences LLC Neuartiges Herbizidresistenz-Gen
EP2471922A1 (de) 2004-05-28 2012-07-04 Asuragen, Inc. Verfahren und Zusammensetzungen mit microRNA
US20060073168A1 (en) 2004-08-11 2006-04-06 Stephens David S Neisseria meningitidis serogroup a capsular polysaccharide acetyltransferase, methods and compositions
US7851152B2 (en) * 2004-09-25 2010-12-14 Yaodong Chen Fluorescent base analogues' usage in the characterization of nucleic acid molecules and their interactions
MX2007004231A (es) 2004-10-08 2007-06-14 Dow Agrosciences Llc Ciertas plantas con concentraciones de acidos grasos "no saturados" o saturados reducidos en semillas y aceite derivado de las semillas._.
US8173611B2 (en) 2004-11-12 2012-05-08 Asuragen Inc. Methods and compositions involving miRNA and miRNA inhibitor molecules
US20090264635A1 (en) 2005-03-25 2009-10-22 Applera Corporation Methods and compositions for depleting abundant rna transcripts
FR2886735B1 (fr) 2005-06-01 2015-09-11 Biomerieux Sa Procede de marquage ou de traitement d'un echantillon biologique contenant des molecules biologiques d'interet, notamment des acides nucleiques
CN103361316B (zh) 2005-10-28 2017-05-17 美国陶氏益农公司 新除草剂抗性基因
EP2115138A2 (de) 2006-09-19 2009-11-11 Asuragen, Inc. Bei pankreatischen erkrankungen differentiell exprimierte mikro-rnas und verwendungen davon
CA2663962A1 (en) 2006-09-19 2008-03-27 Asuragen, Inc. Mir-15, mir-26, mir-31,mir-145, mir-147, mir-188, mir-215, mir-216, mir-331, mmu-mir-292-3p regulated genes and pathways as targets for therapeutic intervention
US8158356B2 (en) 2006-10-16 2012-04-17 Agrigenomics, Inc. Screening for the genetic defect causing tibial hemimelia in bovines
US8044186B2 (en) 2007-05-11 2011-10-25 Wisconsin Alumni Research Foundation Heterologous production of capreomycin and generation of new capreomycin derivatives through metabolic engineering
FR2917090B1 (fr) 2007-06-11 2012-06-15 Biomerieux Sa Reactifs de marquage portant des fonctions diazo et nitro, procedes de synthese de tels reactifs et procedes de detection de molecules biologiques
JP5677703B2 (ja) 2008-01-10 2015-02-25 リサーチ ディベロップメント ファウンデーション Ｅｈｒｌｉｃｈｉａｃｈａｆｆｅｅｎｓｉｓにのためのワクチンおよび診断
WO2009137807A2 (en) 2008-05-08 2009-11-12 Asuragen, Inc. Compositions and methods related to mirna modulation of neovascularization or angiogenesis
FR2934595B1 (fr) 2008-07-29 2013-04-05 Biomerieux Sa Reactifs de marquage ayant un noyau pyridine portant une fonction diazomethyle, procedes de synthese de tels reactifs et procedes de detection de molecules biologiques
US20110045080A1 (en) * 2009-03-24 2011-02-24 William Marsh Rice University Single-Walled Carbon Nanotube/Bioactive Substance Complexes and Methods Related Thereto
UA111936C2 (uk) 2009-12-16 2016-07-11 ДАУ АГРОСАЙЄНСІЗ ЕлЕлСі ТРАНСГЕННА РОСЛИНА, ЯКА МІСТИТЬ ДНК, ЩО КОДУЄ ІНСЕКТИЦИДНИЙ БІЛОК Vip3Ab, І ДНК, ЩО КОДУЄ ІНСЕКТИЦИДНИЙ БІЛОК Cry1Ca, ДЛЯ КЕРУВАННЯ РЕЗИСТЕНТНІСТЮ КОМАХ
CA2782627A1 (en) 2009-12-16 2011-06-23 Dow Agrosciences Llc Combined use of cry1fa and cry1i for management of spodoptera fugiperda and ostrinia nubilalis
US8431346B2 (en) 2009-12-18 2013-04-30 Agrigenomics, Inc. Screening for arthrogryposis multiplex in bovines
WO2011108930A1 (en) 2010-03-04 2011-09-09 Interna Technologies Bv A MiRNA MOLECULE DEFINED BY ITS SOURCE AND ITS DIAGNOSTIC AND THERAPEUTIC USES IN DISEASES OR CONDITIONS ASSOCIATED WITH EMT
BR112012027208A2 (pt) 2010-04-23 2015-09-15 Dow Agrosciences Llc combinações incluindo proteínas cry3aa e cry6aa para evitar o desenvolvimento de resistência em crisomelídeos do sistema radicular do milho (diabrotica spp).
NZ605420A (en) 2010-07-06 2015-02-27 Interna Technologies Bv Mirna and its diagnostic and therapeutic uses in diseases or conditions associated with melanoma, or in diseases or conditions associated with activated braf pathway
FR2968302B1 (fr) 2010-12-06 2012-11-30 Biomerieux Sa Procedes de fonctionalisation et reactifs utilises dans de tels procedes utilisant un anhydride isatoique ou un de ses derives, molecules biologiques ainsi traitees et kits
CN103533828A (zh) 2010-12-16 2014-01-22 陶氏益农公司 Vip3Ab和Cry1Ab用于管理抗性昆虫的组合用途
EP2474617A1 (de) 2011-01-11 2012-07-11 InteRNA Technologies BV MIR zur Behandlung von Neoangiogenese
WO2013040251A2 (en) 2011-09-13 2013-03-21 Asurgen, Inc. Methods and compositions involving mir-135b for distinguishing pancreatic cancer from benign pancreatic disease
US20130157884A1 (en) 2011-10-26 2013-06-20 Asuragen, Inc. Methods and compositions involving mirna expression levels for distinguishing pancreatic cysts
US10167520B2 (en) 2011-12-06 2019-01-01 Scot E. Dowd Universal or broad range assays and multi-tag sample specific diagnostic process using non-optical sequencing
EP3369818B1 (de) 2011-12-22 2021-06-09 InteRNA Technologies B.V. Mirna zur behandlung von kopf-hals-karzinom
US9994604B2 (en) 2012-05-31 2018-06-12 Bio-Lab Ltd. Pyrazolotriazolyl nucleoside analogues and oligonucleotides comprising them
FR2994184B1 (fr) 2012-08-02 2017-12-08 Biomerieux Sa Procedes de fonctionalisation et reactifs utilises dans de tels procedes utilisant un anhydride aza-isatoique ou un de ses derives, molecules biologiques ainsi traitees et kits
EP2897633B1 (de) 2012-09-18 2020-01-01 UTI Limited Partnership Behandlung von schmerzen durch hemmung von usp5-deubiquitinase
US20140100124A1 (en) 2012-10-04 2014-04-10 Asuragen, Inc. Diagnostic mirnas for differential diagnosis of incidental pancreatic cystic lesions
CA2886787A1 (en) 2012-10-05 2014-04-10 Dow Agrosciences Llc Use of cry1ea in combinations for management of resistant fall armyworm insects
WO2014072357A1 (en) 2012-11-06 2014-05-15 Interna Technologies B.V. Combination for use in treating diseases or conditions associated with melanoma, or treating diseases or conditions associated with activated b-raf pathway
US10398661B2 (en) 2013-02-28 2019-09-03 The Board Of Regents Of The University Of Texas System Methods for classifying a cancer as susceptible to TMEPAI-directed therapies and treating such cancers
WO2014144666A2 (en) 2013-03-15 2014-09-18 The University Of Chicago Methods and compositions related to t-cell activity
EP3065706A4 (de) 2013-11-08 2017-11-29 Baylor Research Institute Nukleare lokalisierung von glp-1 zur stimulation der herzmuskelregenerierung und reversion von herzversagen
US10087444B2 (en) 2014-02-13 2018-10-02 The Board Of Regents Of The University Of Texas System MicroRNA composition for the treatment of neuroblastoma
EP3259346A4 (de) 2015-02-20 2018-07-11 Baylor College of Medicine P63-inaktivierung zur behandlung von herzinsuffizienz
BR112018002399A2 (pt) 2015-08-06 2018-09-25 Chimerix, Inc. nucleosídeos de pirrolopirimidina e análogos dos mesmos, úteis como agentes antivirais
KR20180091816A (ko) 2015-10-14 2018-08-16 바이오-패쓰 홀딩스 인크. 리포좀 제제를 위한 p-에톡시 핵산
CA3019635A1 (en) 2016-03-31 2017-10-05 Baylor Research Institute Angiopoietin-like protein 8 (angptl8)
EP3500581A4 (de) 2016-08-17 2021-10-06 Solstice Biologics, Ltd. Polynukleotidkonstrukte
MX2019003070A (es) 2016-09-16 2019-10-14 Bio Path Holdings Inc Terapia de combinacion con oligonucleotidos antisentido liposomales.
EP3522720A4 (de) 2016-09-30 2020-04-29 Dow Agrosciences LLC Binäre insektizide cry-toxine
KR102187291B1 (ko) 2016-11-21 2020-12-07 나노스트링 테크놀로지스, 인크. 화학적 조성물 및 이것을 사용하는 방법
US11597744B2 (en) 2017-06-30 2023-03-07 Sirius Therapeutics, Inc. Chiral phosphoramidite auxiliaries and methods of their use
US11111264B2 (en) 2017-09-21 2021-09-07 Chimerix, Inc. Morphic forms of 4-amino-7-(3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2-methyl-7H-pyrrolo[2,3-d]pyrimidine-5-carboxamide and uses thereof
WO2019086603A1 (en) 2017-11-03 2019-05-09 Interna Technologies B.V. Mirna molecule, equivalent, antagomir, or source thereof for treating and/or diagnosing a condition and/or a disease associated with neuronal deficiency or for neuronal (re)generation
CN111936150A (zh) 2018-02-12 2020-11-13 因特尔纳技术有限公司 抗癌微小rna及其脂质制剂
KR20210061962A (ko) 2018-05-14 2021-05-28 나노스트링 테크놀로지스, 인크. 화학 조성물 및 이의 사용 방법
CA3130693A1 (en) 2019-02-19 2020-08-27 Ultima Genomics, Inc. Linkers and methods for optical detection and sequencing
US11807851B1 (en) 2020-02-18 2023-11-07 Ultima Genomics, Inc. Modified polynucleotides and uses thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3960840A (en) * 1972-12-29 1976-06-01 University Of Illinois Foundaton Fluorescent derivatives of adenine-containing compounds
US4415732A (en) * 1981-03-27 1983-11-15 University Patents, Inc. Phosphoramidite compounds and processes
US4849513A (en) * 1983-12-20 1989-07-18 California Institute Of Technology Deoxyribonucleoside phosphoramidites in which an aliphatic amino group is attached to the sugar ring and their use for the preparation of oligonucleotides containing aliphatic amino groups
US4828979A (en) * 1984-11-08 1989-05-09 Life Technologies, Inc. Nucleotide analogs for nucleic acid labeling and detection
US4683202A (en) * 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
WO1987001373A1 (en) * 1985-09-09 1987-03-12 Teijin Limited Pyridopyrimidine nucleotide derivatives
US5093232A (en) * 1985-12-11 1992-03-03 Chiron Corporation Nucleic acid probes
US4910300A (en) * 1985-12-11 1990-03-20 Chiron Corporation Method for making nucleic acid probes
US5091310A (en) * 1988-09-23 1992-02-25 Cetus Corporation Structure-independent dna amplification by the polymerase chain reaction
EP0628051B1 (de) * 1992-02-12 2003-07-02 Chromagen, Inc. Verwendungen von fluoreszierenden n-nukleosiden und dessen analogen

Also Published As

Publication number Publication date
EP0628051B1 (de) 2003-07-02
CA2129105A1 (en) 1993-08-19
US5763167A (en) 1998-06-09
WO1993016094A3 (en) 1993-09-30
EP0628051A1 (de) 1994-12-14
DE69333073T2 (de) 2004-04-15
JPH07504087A (ja) 1995-05-11
DE69333073D1 (de) 2003-08-07
WO1993016094A2 (en) 1993-08-19

Similar Documents

Publication Publication Date Title
ATE244259T1 (de) Verwendungen von fluoreszierenden n-nukleosiden und dessen analogen
ES2118593T3 (es) Analogos de nucleotidos de pteridina como sondas fluorescentes de adn.
DE69028257D1 (de) Verfahren zur Vervielfältigung von Nukleinsäuresequenzen
DK0970240T3 (da) Kunstig fejlparringshydridisering
EP1034302A4 (de) De novo oder "universaler" sequenzierungs-array
ATE315666T1 (de) Methode zur amplifizierung und möglicher charakterisierung von nukleinsäuren
DE60044367D1 (de) Nichtaggregierende, nichtausschaltende oligomere, nukleotid-analoga enthaltend; verfahren zu deren herstellung und verwendung
ES2100390T3 (es) Pruebas para micobacterias.
ATE542916T1 (de) Methoden zur erzeugung von oligonukleotidlösungen
EP0774518A3 (de) Nukleinsäure-Sonden complementär zu Nukleinsäure von humane Papillomavirus, entsprechende Verfahren und Kits
ATE373105T1 (de) Verbindungen und methoden zum nachweis von biomolekülen
CA2295306A1 (en) Dna polymerase-related factors
DE69518697D1 (de) Nachweis von Treponema Pallidum und Haemophilus Ducreyi
ATE242261T1 (de) Fluoreszend-konjugaten von nukleosiden und von nukleotiden, ihrer verfahren zur herstellung und ihrer verwendungen
DE59712871D1 (de) Heterocyclische verbindungen und deren verwendung in der detektion von nucleinsäuren
Doronin et al. Photoaffinity labeling of DNA polymerase α DNA primase complex based on the catalytic competence of a dNTP reactive analog
LTIP1519A (en) Solution, set, process for elongation of the oligonucleotidic primer, process of dna amplification
DE69616102D1 (de) Amplikationsprimern und Nukleinsäuresonden zum Nachweis von Coccidioides immites
WO1994012518A3 (de) Reagenz zur kupplung veschiedener substanzen an nukleinsäuren sowie verfahren zu dessen herstellung
ATE137807T1 (de) Systeme für amplifikation/nachweis von nukleinsäuren
Milton et al. Site-specific disulfide bridges in oligodeoxyribonucleotide duplexes containing 6-mercaptopurine and 4-thiothymine bases
DE69928543D1 (de) Pteridine-nukleotid-analoge
TH9675EX (th) วิธีการวิเคราะห์แบบใหม่

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 0628051

Country of ref document: EP

REN Ceased due to non-payment of the annual fee
RZN Patent revoked
RZN Patent revoked