DE60044367D1 - Nichtaggregierende, nichtausschaltende oligomere, nukleotid-analoga enthaltend; verfahren zu deren herstellung und verwendung - Google Patents
Nichtaggregierende, nichtausschaltende oligomere, nukleotid-analoga enthaltend; verfahren zu deren herstellung und verwendungInfo
- Publication number
- DE60044367D1 DE60044367D1 DE60044367T DE60044367T DE60044367D1 DE 60044367 D1 DE60044367 D1 DE 60044367D1 DE 60044367 T DE60044367 T DE 60044367T DE 60044367 T DE60044367 T DE 60044367T DE 60044367 D1 DE60044367 D1 DE 60044367D1
- Authority
- DE
- Germany
- Prior art keywords
- agglomerating
- preparation
- oligomers
- nucleotide analogs
- analogs containing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
- C07K14/003—Peptide-nucleic acids (PNAs)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6832—Enhancement of hybridisation reaction
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
- C12Q1/6818—Hybridisation assays characterised by the detection means involving interaction of two or more labels, e.g. resonant energy transfer
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/447,936 US6660845B1 (en) | 1999-11-23 | 1999-11-23 | Non-aggregating, non-quenching oligomers comprising nucleotide analogues; methods of synthesis and use thereof |
PCT/US2000/032265 WO2001038584A2 (en) | 1999-11-23 | 2000-11-21 | Non-aggregating, non-quenching oligomers comprising nucleotide analogues; methods of synthesis and use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60044367D1 true DE60044367D1 (de) | 2010-06-17 |
Family
ID=23778351
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60044367T Expired - Lifetime DE60044367D1 (de) | 1999-11-23 | 2000-11-21 | Nichtaggregierende, nichtausschaltende oligomere, nukleotid-analoga enthaltend; verfahren zu deren herstellung und verwendung |
Country Status (9)
Country | Link |
---|---|
US (3) | US6660845B1 (de) |
EP (1) | EP1232157B1 (de) |
JP (1) | JP2003527579A (de) |
AT (1) | ATE466864T1 (de) |
AU (1) | AU1798901A (de) |
CA (1) | CA2392033C (de) |
DE (1) | DE60044367D1 (de) |
ES (1) | ES2344337T3 (de) |
WO (1) | WO2001038584A2 (de) |
Families Citing this family (94)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1278894A1 (de) * | 2000-05-02 | 2003-01-29 | Centre National De La Recherche Scientifique | Identifizierung genetischer marker |
AU784561B2 (en) * | 2000-06-23 | 2006-05-04 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Positively-charged peptide nucleic acid analogs with improved properties |
DE60140804D1 (de) * | 2000-06-27 | 2010-01-28 | Nat Inst Of Advanced Ind Scien | Neue nukleinsäuresonden und verfahren zum testen von nukleinsäuren unter deren verwendung |
US7198924B2 (en) | 2000-12-11 | 2007-04-03 | Invitrogen Corporation | Methods and compositions for synthesis of nucleic acid molecules using multiple recognition sites |
US20030082547A1 (en) | 2001-08-27 | 2003-05-01 | Ewing Gregory J. | Non-fluorescent quencher compounds and biomolecular assays |
US6972339B2 (en) | 2001-09-07 | 2005-12-06 | Epoch Biosciences, Inc. | Compounds and methods for fluorescent labeling |
US8569516B2 (en) * | 2001-09-07 | 2013-10-29 | Elitech Holding B.V. | Compounds and methods for fluorescent labeling |
CA2464031A1 (en) | 2001-10-30 | 2003-05-08 | Conforma Therapeutics Corporation | Purine analogs having hsp90-inhibiting activity |
EP1442137A4 (de) | 2001-11-07 | 2005-08-31 | Applera Corp | Universelle nukleotide für die nukleinsäureanalyse |
AU2002362013B2 (en) | 2001-11-21 | 2008-04-24 | Applied Biosystems, Llc. | Digital assay |
US20040063109A2 (en) | 2002-01-25 | 2004-04-01 | Applera Corporation | Single-tube, ready-to-use assay kits, and methods using same |
US6818420B2 (en) * | 2002-02-27 | 2004-11-16 | Biosource International, Inc. | Methods of using FET labeled oligonucleotides that include a 3′-5′ exonuclease resistant quencher domain and compositions for practicing the same |
CA2472554A1 (en) * | 2002-02-27 | 2003-09-04 | Biosource International Inc. | Methods of using fet labeled oligonucleotides that include a 3' 5' exonuclease resistant quencher domain and compositions for practicing the same |
CA2512319A1 (en) | 2003-01-14 | 2004-08-05 | Gilead Sciences, Inc. | Compositions and methods for combination antiviral therapy |
US7429596B2 (en) * | 2003-06-20 | 2008-09-30 | The Regents Of The University Of California | 1H-pyrrolo [2,3-D] pyrimidine derivatives and methods of use thereof |
WO2005012324A2 (en) | 2003-07-30 | 2005-02-10 | Gilead Sciences, Inc. | Nucleobase phosphonate analogs for antiviral treatment |
WO2005028434A2 (en) | 2003-09-18 | 2005-03-31 | Conforma Therapeutics Corporation | Novel heterocyclic compounds as hsp90-inhibitors |
US7541454B2 (en) * | 2003-10-24 | 2009-06-02 | Epoch Biosciences, Inc. | Compounds and methods for fluorescent labeling |
PT1687609E (pt) * | 2003-10-28 | 2015-03-02 | Epoch Biosciences Inc | Sondas fluorescentes para a detecção de adn por hibridação com uma maior sensibilidade e menor ruído de fundo |
ATE419263T1 (de) | 2003-11-20 | 2009-01-15 | Exiqon As | Löscher-zusammensetzung mit anthraquinon |
EP1697534B1 (de) | 2003-12-01 | 2010-06-02 | Life Technologies Corporation | Rekombinationsstellen enthaltende nukleinsäuremoleküle und verfahren zur verwendung davon |
WO2006068760A2 (en) | 2004-11-19 | 2006-06-29 | The Regents Of The University Of California | Anti-inflammatory pyrazolopyrimidines |
US20060228726A1 (en) | 2005-01-06 | 2006-10-12 | Martin Patrick K | Polypeptides having nucleic acid binding activity and compositions and methods for nucleic acid amplification |
US20060153745A1 (en) * | 2005-01-11 | 2006-07-13 | Applera Corporation | Fluid processing device for oligonucleotide synthesis and analysis |
US20070059713A1 (en) | 2005-09-09 | 2007-03-15 | Lee Jun E | SSB-DNA polymerase fusion proteins |
CA2624634A1 (en) | 2005-10-03 | 2007-04-12 | Applera Corporation | Compositions, methods, and kits for amplifying nucleic acids |
EP1994182B1 (de) | 2006-03-15 | 2019-05-29 | Siemens Healthcare Diagnostics Inc. | Abgleit-nucleobase-analoga |
MX2008012928A (es) * | 2006-04-04 | 2009-03-06 | Univ California | Antagonistas de pi3-cinasa. |
US7842672B2 (en) | 2006-07-07 | 2010-11-30 | Gilead Sciences, Inc. | Phosphonate inhibitors of HCV |
JP2009545317A (ja) | 2006-08-01 | 2009-12-24 | アプライド バイオシステムズ, エルエルシー | 分析物および核酸の検出 |
US9938641B2 (en) | 2006-12-18 | 2018-04-10 | Fluidigm Corporation | Selection of aptamers based on geometry |
GB2467670B (en) | 2007-10-04 | 2012-08-01 | Intellikine Inc | Chemical entities and therapeutic uses thereof |
US8017338B2 (en) | 2007-11-20 | 2011-09-13 | Life Technologies Corporation | Reversible di-nucleotide terminator sequencing |
US8193182B2 (en) | 2008-01-04 | 2012-06-05 | Intellikine, Inc. | Substituted isoquinolin-1(2H)-ones, and methods of use thereof |
CN101965336B (zh) | 2008-01-04 | 2015-06-17 | 英特利凯恩有限责任公司 | 某些化学实体、组合物和方法 |
US8993580B2 (en) | 2008-03-14 | 2015-03-31 | Intellikine Llc | Benzothiazole kinase inhibitors and methods of use |
WO2009114870A2 (en) | 2008-03-14 | 2009-09-17 | Intellikine, Inc. | Kinase inhibitors and methods of use |
US20110224223A1 (en) | 2008-07-08 | 2011-09-15 | The Regents Of The University Of California, A California Corporation | MTOR Modulators and Uses Thereof |
CA2730106A1 (en) | 2008-07-08 | 2010-01-14 | Intellikine, Inc. | Kinase inhibitors and methods of use |
ES2517919T3 (es) * | 2008-09-02 | 2014-11-04 | The Governing Council Of The University Of Toronto | Microelectrodos nanoestructurados y dispositivos de biodetección que los incorporan |
WO2010030716A1 (en) * | 2008-09-10 | 2010-03-18 | Igor Kutyavin | Detection of nucleic acids by oligonucleotide probes cleaved in presence of endonuclease v |
JP5731978B2 (ja) | 2008-09-26 | 2015-06-10 | インテリカイン, エルエルシー | 複素環キナーゼ阻害剤 |
ES2570429T3 (es) | 2008-10-16 | 2016-05-18 | Univ California | Inhibidores de heteroaril quinasa de anillo condensado |
US8476431B2 (en) | 2008-11-03 | 2013-07-02 | Itellikine LLC | Benzoxazole kinase inhibitors and methods of use |
WO2010114894A1 (en) | 2009-03-31 | 2010-10-07 | Arqule, Inc. | Substituted heterocyclic compounds |
CA2760791C (en) | 2009-05-07 | 2017-06-20 | Intellikine, Inc. | Heterocyclic compounds and uses thereof |
EP3150619B1 (de) | 2009-05-21 | 2019-09-18 | Siemens Healthcare Diagnostics Inc. | Universaletiketten mit nicht natürlichen nukleobasen |
WO2011047384A2 (en) | 2009-10-16 | 2011-04-21 | The Regents Of The University Of California | Methods of inhibiting ire1 |
US20110151457A1 (en) | 2009-12-22 | 2011-06-23 | Elitech Holding B.V. | Hypertheromostable endonuclease iv substrate probe |
ES2593256T3 (es) | 2010-05-21 | 2016-12-07 | Infinity Pharmaceuticals, Inc. | Compuestos químicos, composiciones y métodos para las modulaciones de cinasas |
WO2012056319A1 (en) | 2010-10-27 | 2012-05-03 | Dynamix Pharmaceuticals Ltd. | Sulfonamides for the modulation of pkm2 |
CA2817577A1 (en) | 2010-11-10 | 2012-05-18 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
DK2663309T3 (en) | 2011-01-10 | 2017-06-19 | Infinity Pharmaceuticals Inc | METHODS FOR PRODUCING ISOQUINOLINONES AND SOLID FORMS OF ISOQUINOLINONES |
EP2663857B1 (de) | 2011-01-11 | 2018-12-12 | The Governing Council Of The University Of Toronto | Proteinnachweisverfahren |
ES2818586T3 (es) * | 2011-02-07 | 2021-04-13 | Governing Council Univ Toronto | Biosondas y métodos de uso de las mismas |
TWI592411B (zh) | 2011-02-23 | 2017-07-21 | 英特爾立秦有限責任公司 | 激酶抑制劑之組合及其用途 |
WO2012122564A2 (en) | 2011-03-10 | 2012-09-13 | Xagenic, Inc. | Diagnostic and sample preparation devices and methods |
AU2012284088B2 (en) | 2011-07-19 | 2015-10-08 | Infinity Pharmaceuticals Inc. | Heterocyclic compounds and uses thereof |
MX2014000648A (es) | 2011-07-19 | 2014-09-25 | Infinity Pharmaceuticals Inc | Compuestos heterociclicos y sus usos. |
EP2548878A1 (de) * | 2011-07-21 | 2013-01-23 | Laboratorios Del. Dr. Esteve, S.A. | Pyrazolo[3,4-d]pyrimidin-Verbindungen, deren Herstellung und Verwendung als Sigma-Liganden |
KR20140075693A (ko) | 2011-08-29 | 2014-06-19 | 인피니티 파마슈티칼스, 인코포레이티드 | 헤테로사이클릭 화합물 및 그의 용도 |
EP2751112B1 (de) | 2011-09-02 | 2019-10-09 | The Regents of The University of California | Substituierte pyrazolo[3,4-d]pyrimidine und ihre verwendung |
US8940742B2 (en) | 2012-04-10 | 2015-01-27 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
US8828998B2 (en) | 2012-06-25 | 2014-09-09 | Infinity Pharmaceuticals, Inc. | Treatment of lupus, fibrotic conditions, and inflammatory myopathies and other disorders using PI3 kinase inhibitors |
US9695416B2 (en) | 2012-07-18 | 2017-07-04 | Siemens Healthcare Diagnostics Inc. | Method of normalizing biological samples |
KR20150041657A (ko) * | 2012-08-17 | 2015-04-16 | 더 유나이티드 스테이츠 오브 어메리카, 애즈 리프리젠티드 바이 더 세크러테리, 디파트먼트 오브 헬쓰 앤드 휴먼 서비씨즈 | 핵산의 정성적 및 정량적 검출을 위한 시클로펜탄-펩티드 핵산 |
CN104995192A (zh) | 2012-09-26 | 2015-10-21 | 加利福尼亚大学董事会 | Ire1的调节 |
US10590474B2 (en) | 2013-03-11 | 2020-03-17 | Elitechgroup B.V. | Methods for true isothermal strand displacement amplification |
US20140255928A1 (en) | 2013-03-11 | 2014-09-11 | Elitech Holding B.V. | Methods for true isothermal strand displacement amplification |
US10975423B2 (en) | 2013-03-11 | 2021-04-13 | Elitechgroup, Inc. | Methods for true isothermal strand displacement amplification |
US9169256B2 (en) | 2013-03-13 | 2015-10-27 | Elitechgroup B.V. | Artificial nucleic acids |
WO2014152673A1 (en) | 2013-03-14 | 2014-09-25 | Shire Human Genetic Therapies, Inc. | Quantitative assessment for cap efficiency of messenger rna |
AU2014239250A1 (en) | 2013-03-14 | 2015-08-27 | Shire Human Genetic Therapies, Inc. | Quantitative assessment for cap efficiency of messenger RNA |
US9481667B2 (en) | 2013-03-15 | 2016-11-01 | Infinity Pharmaceuticals, Inc. | Salts and solid forms of isoquinolinones and composition comprising and methods of using the same |
NZ718430A (en) | 2013-10-04 | 2021-12-24 | Infinity Pharmaceuticals Inc | Heterocyclic compounds and uses thereof |
WO2015051241A1 (en) | 2013-10-04 | 2015-04-09 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
EA201691872A1 (ru) | 2014-03-19 | 2017-04-28 | Инфинити Фармасьютикалз, Инк. | Гетероциклические соединения для применения в лечении pi3k-гамма-опосредованных расстройств |
WO2015160975A2 (en) | 2014-04-16 | 2015-10-22 | Infinity Pharmaceuticals, Inc. | Combination therapies |
US20170247756A1 (en) | 2014-10-03 | 2017-08-31 | Life Technologies Corporation | Genetic sequence verification compositions, methods and kits |
US9708348B2 (en) | 2014-10-03 | 2017-07-18 | Infinity Pharmaceuticals, Inc. | Trisubstituted bicyclic heterocyclic compounds with kinase activities and uses thereof |
WO2016090165A1 (en) | 2014-12-03 | 2016-06-09 | Life Technologies Corporation | Charged reactive oligomers |
EP3247797B1 (de) | 2015-01-12 | 2020-04-29 | Life Technologies Corporation | Verfahren, systeme und zusammensetzungen daraus zur kontrolle und quantifizierung der nukleinsäurebibliotheksqualität |
CN114230571A (zh) | 2015-09-14 | 2022-03-25 | 无限药品股份有限公司 | 异喹啉酮的固体形式、其制备方法、包含其的组合物及其使用方法 |
US10865396B2 (en) | 2015-10-29 | 2020-12-15 | Temple University—Of the Commonwealth System of Higher Education | Modification of 3′ terminal ends of nucleic acids by DNA polymerase theta |
TWI747873B (zh) | 2016-02-01 | 2021-12-01 | 美商百歐克斯製藥公司 | 苯并吡唑化合物及其類似物 |
WO2017161116A1 (en) | 2016-03-17 | 2017-09-21 | Infinity Pharmaceuticals, Inc. | Isotopologues of isoquinolinone and quinazolinone compounds and uses thereof as pi3k kinase inhibitors |
WO2017214269A1 (en) | 2016-06-08 | 2017-12-14 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
JP7054681B2 (ja) | 2016-06-24 | 2022-04-14 | インフィニティー ファーマシューティカルズ, インコーポレイテッド | 組合せ療法 |
US10738346B2 (en) | 2017-03-09 | 2020-08-11 | Elitechgroup, Inc. | Nitrodiarylethenes as fluorescence quenchers for nucleic acid probes |
WO2019036225A1 (en) | 2017-08-17 | 2019-02-21 | Elitechgroup, Inc. | FLUORESCENCE EXTINGUISHERS STABILIZING DUPLEX FOR NUCLEIC PROBES |
EP3802526A1 (de) | 2018-05-29 | 2021-04-14 | ELITechGroup, Inc. | Carborhodaminverbindungen und verfahren zu ihrer herstellung |
WO2021080629A1 (en) | 2019-10-23 | 2021-04-29 | Elitechgroup, Inc. | Methods for true isothermal strand displacement amplification |
KR20240017865A (ko) | 2021-06-04 | 2024-02-08 | 트랜슬레이트 바이오 인코포레이티드 | Mrna 캡핑 효율의 정량적 평가를 위한 분석 |
CN115418395B (zh) * | 2022-11-07 | 2023-01-17 | 百力格生物科技(上海)股份有限公司 | Mgb探针溶解方法及其溶液 |
Family Cites Families (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3529478A1 (de) | 1985-08-16 | 1987-02-19 | Boehringer Mannheim Gmbh | 7-desaza-2'desoxyguanosin-nukleotide, verfahren zu deren herstellung und deren verwendung zur nukleinsaeure-sequenzierung |
US5422251A (en) | 1986-11-26 | 1995-06-06 | Princeton University | Triple-stranded nucleic acids |
US6270961B1 (en) | 1987-04-01 | 2001-08-07 | Hyseq, Inc. | Methods and apparatus for DNA sequencing and DNA identification |
US5202231A (en) | 1987-04-01 | 1993-04-13 | Drmanac Radoje T | Method of sequencing of genomes by hybridization of oligonucleotide probes |
US5525464A (en) | 1987-04-01 | 1996-06-11 | Hyseq, Inc. | Method of sequencing by hybridization of oligonucleotide probes |
DE3739366A1 (de) | 1987-04-10 | 1988-10-27 | Boehringer Mannheim Gmbh | Desaza-purin-nucleosid-derivate, verfahren zu deren herstellung sowie deren verwendung bei der nucleinsaeure-sequenzierung sowie als antivirale mittel |
US5824796A (en) | 1988-09-28 | 1998-10-20 | Epoch Pharmaceuticals, Inc. | Cross-linking oligonucleotides |
US5176996A (en) | 1988-12-20 | 1993-01-05 | Baylor College Of Medicine | Method for making synthetic oligonucleotides which bind specifically to target sites on duplex DNA molecules, by forming a colinear triplex, the synthetic oligonucleotides and methods of use |
JPH04507402A (ja) | 1989-05-18 | 1992-12-24 | マイクロプローブ・コーポレーション | 架橋オリゴヌクレオチド |
US5210015A (en) | 1990-08-06 | 1993-05-11 | Hoffman-La Roche Inc. | Homogeneous assay system using the nuclease activity of a nucleic acid polymerase |
US5177196A (en) * | 1990-08-16 | 1993-01-05 | Microprobe Corporation | Oligo (α-arabinofuranosyl nucleotides) and α-arabinofuranosyl precursors thereof |
US5512667A (en) | 1990-08-28 | 1996-04-30 | Reed; Michael W. | Trifunctional intermediates for preparing 3'-tailed oligonucleotides |
DK0834576T3 (da) | 1990-12-06 | 2002-04-22 | Affymetrix Inc A Delaware Corp | Påvisning af nukleinsyresekvenser |
DK51092D0 (da) * | 1991-05-24 | 1992-04-15 | Ole Buchardt | Oligonucleotid-analoge betegnet pna, monomere synthoner og fremgangsmaade til fremstilling deraf samt anvendelser deraf |
US5766855A (en) | 1991-05-24 | 1998-06-16 | Buchardt, Deceased; Ole | Peptide nucleic acids having enhanced binding affinity and sequence specificity |
US5539082A (en) | 1993-04-26 | 1996-07-23 | Nielsen; Peter E. | Peptide nucleic acids |
US5714331A (en) | 1991-05-24 | 1998-02-03 | Buchardt, Deceased; Ole | Peptide nucleic acids having enhanced binding affinity, sequence specificity and solubility |
US5419966A (en) | 1991-06-10 | 1995-05-30 | Microprobe Corporation | Solid support for synthesis of 3'-tailed oligonucleotides |
US5594121A (en) | 1991-11-07 | 1997-01-14 | Gilead Sciences, Inc. | Enhanced triple-helix and double-helix formation with oligomers containing modified purines |
EP0691980B1 (de) * | 1993-03-30 | 1997-06-04 | Sanofi | 7-deazapurin modifizierte oligonukleotide |
US6077668A (en) * | 1993-04-15 | 2000-06-20 | University Of Rochester | Highly sensitive multimeric nucleic acid probes |
US6156501A (en) | 1993-10-26 | 2000-12-05 | Affymetrix, Inc. | Arrays of modified nucleic acid probes and methods of use |
WO1996011937A1 (en) * | 1994-10-14 | 1996-04-25 | Stratagene | Porphyrin labeling of polynucleotides |
US5556752A (en) | 1994-10-24 | 1996-09-17 | Affymetrix, Inc. | Surface-bound, unimolecular, double-stranded DNA |
DE4438918A1 (de) | 1994-11-04 | 1996-05-09 | Hoechst Ag | Modifizierte Oligonukleotide, deren Herstellung sowie deren Verwendung |
US5801155A (en) | 1995-04-03 | 1998-09-01 | Epoch Pharmaceuticals, Inc. | Covalently linked oligonucleotide minor grove binder conjugates |
US6312894B1 (en) | 1995-04-03 | 2001-11-06 | Epoch Pharmaceuticals, Inc. | Hybridization and mismatch discrimination using oligonucleotides conjugated to minor groove binders |
US20010018514A1 (en) * | 1998-07-31 | 2001-08-30 | Mcgall Glenn H. | Nucleic acid labeling compounds |
US6143877A (en) | 1997-04-30 | 2000-11-07 | Epoch Pharmaceuticals, Inc. | Oligonucleotides including pyrazolo[3,4-D]pyrimidine bases, bound in double stranded nucleic acids |
CA2318880C (en) | 1998-02-04 | 2010-07-27 | Perkin-Elmer Corporation | Determination of a genotype of an amplification product at multiple allelic sites |
US6127121A (en) | 1998-04-03 | 2000-10-03 | Epoch Pharmaceuticals, Inc. | Oligonucleotides containing pyrazolo[3,4-D]pyrimidines for hybridization and mismatch discrimination |
JP2001013103A (ja) * | 1999-04-28 | 2001-01-19 | Fuji Photo Film Co Ltd | 走査型電気化学顕微鏡による試料核酸断片の検出方法および定量方法 |
JP4320104B2 (ja) * | 1999-06-07 | 2009-08-26 | 富士フイルム株式会社 | 部分相補性核酸断片の検出方法 |
US6316230B1 (en) * | 1999-08-13 | 2001-11-13 | Applera Corporation | Polymerase extension at 3′ terminus of PNA-DNA chimera |
-
1999
- 1999-11-23 US US09/447,936 patent/US6660845B1/en not_active Expired - Lifetime
-
2000
- 2000-11-21 DE DE60044367T patent/DE60044367D1/de not_active Expired - Lifetime
- 2000-11-21 JP JP2001539925A patent/JP2003527579A/ja active Pending
- 2000-11-21 WO PCT/US2000/032265 patent/WO2001038584A2/en active Application Filing
- 2000-11-21 AT AT00980769T patent/ATE466864T1/de not_active IP Right Cessation
- 2000-11-21 AU AU17989/01A patent/AU1798901A/en not_active Abandoned
- 2000-11-21 EP EP00980769A patent/EP1232157B1/de not_active Expired - Lifetime
- 2000-11-21 ES ES00980769T patent/ES2344337T3/es not_active Expired - Lifetime
- 2000-11-21 CA CA2392033A patent/CA2392033C/en not_active Expired - Lifetime
-
2003
- 2003-11-04 US US10/702,007 patent/US6972328B2/en not_active Expired - Lifetime
-
2005
- 2005-05-13 US US11/129,003 patent/US20050239121A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CA2392033A1 (en) | 2001-05-31 |
WO2001038584A3 (en) | 2001-10-25 |
ATE466864T1 (de) | 2010-05-15 |
WO2001038584A2 (en) | 2001-05-31 |
ES2344337T3 (es) | 2010-08-25 |
EP1232157A2 (de) | 2002-08-21 |
AU1798901A (en) | 2001-06-04 |
US20040116689A1 (en) | 2004-06-17 |
US6660845B1 (en) | 2003-12-09 |
JP2003527579A (ja) | 2003-09-16 |
CA2392033C (en) | 2010-02-09 |
US6972328B2 (en) | 2005-12-06 |
EP1232157B1 (de) | 2010-05-05 |
US20050239121A1 (en) | 2005-10-27 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE60044367D1 (de) | Nichtaggregierende, nichtausschaltende oligomere, nukleotid-analoga enthaltend; verfahren zu deren herstellung und verwendung | |
DE69333073D1 (de) | Verwendungen von fluoreszierenden n-nukleosiden und dessen analogen | |
IL145497A0 (en) | L-ribo-lna analogues | |
DE69941441D1 (de) | Methode für DNA synthese | |
IL123694A (en) | Primers modified at exocyclic amine of purine or pyrimidine bases | |
ES2192672T3 (es) | Nuevos analogos de nucleotidos. | |
AU2001268468A1 (en) | Use of nucleotide analogs in the analysis of oligonucleotide mixtures and in highly multiplexed nucleic acid sequencing | |
IL100298A (en) | 3(-(2()-amino- or thiol- modified, fluorescent dye- coupled nucleosides, nucleotides and oligonucleotides, and a process for the preparation and the use thereof | |
FI961283A0 (fi) | Tehokkaan nukleiinihapposekvensoinnin menetelmiä ja koostumuksia | |
DE60325016D1 (de) | Oligonukleotide mit alternierenden segmenten und deren verwendungen | |
IL172015A0 (en) | Pyrimidine compounds having phosphonate groups as antiviral nucleotide analogs | |
WO2001047944A3 (en) | Nucleic acids containing single nucleotide polymorphisms and methods of use thereof | |
CA2506797A1 (en) | Detectable labeled nucleoside analogs and methods of use thereof | |
WO2000029623A3 (en) | Nucleic acids containing single nucleotide polymorphisms and methods of use thereof | |
DE69815370D1 (de) | Fluoreszend-konjugaten von nukleosiden und von nukleotiden, ihrer verfahren zur herstellung und ihrer verwendungen | |
ATE304541T1 (de) | Verfahren zur herstellung von purinderivaten und dessen zwischenprodukte | |
ATE203271T1 (de) | Für die protein-kinase a-spezifische modifizierte oligonukleotide und verfahren zur deren verwendung | |
WO2001048245A3 (en) | Nucleic acids containing single nucleotide polymorphisms and methods of use thereof | |
WO2001040521A3 (en) | Nucleic acids containing single nucleotide polymorphisms and methods of use thereof | |
DE69900297T2 (de) | Akarizid und insektizid wirksame, substituierte Pyrimidine und Verfahren zu ihrer Herstellung | |
ATE332971T1 (de) | Typ ii dns polymerase aus pyrococcus abyssi | |
Yamada et al. | A new modified cytosine base capable of base pairing with guanine using four hydrogen bonds | |
ATE300534T1 (de) | Verfahren und zwischenverbindungen zur herstellung von imidazopyridinen | |
DE60335805D1 (de) | Verfahren zur herstellung von 1,3-dioxolan-nucleosiden | |
ATE469904T1 (de) | Pyren-gebundene pyrrolo(2,1-c)(1,4)benzodiazepin- derivate zur verwendung als antikrebsmittel |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |