ES2192672T3 - Nuevos analogos de nucleotidos. - Google Patents

Nuevos analogos de nucleotidos.

Info

Publication number
ES2192672T3
ES2192672T3 ES97912488T ES97912488T ES2192672T3 ES 2192672 T3 ES2192672 T3 ES 2192672T3 ES 97912488 T ES97912488 T ES 97912488T ES 97912488 T ES97912488 T ES 97912488T ES 2192672 T3 ES2192672 T3 ES 2192672T3
Authority
ES
Spain
Prior art keywords
nucleotides
new analogs
hydrolyzable
oligo
minimally
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97912488T
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English (en)
Inventor
Takeshi Imanishi
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Individual
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Individual
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Filing date
Publication date
Application filed by Individual filed Critical Individual
Application granted granted Critical
Publication of ES2192672T3 publication Critical patent/ES2192672T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/323—Chemical structure of the sugar modified ring structure
    • C12N2310/3231—Chemical structure of the sugar modified ring structure having an additional ring, e.g. LNA, ENA

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

LA INVENCION SE REFIERE A UN ANALOGO DE OLIGONUCLEOTIDO O A UNA MOLECULA ANTISENTIDO, QUE ES MINIMAMENTE HIDROLIZABLE CON UNA ENZIMA IN VIVO, PRESENTA UNA ELEVADA CAPACIDAD DE UNION DE HEBRA EN EL MISMO SENTIDO Y SE SINTETIZA FACILMENTE. DICHO OLIGONUCLEOTIDO O POLINUCLEOTIDO CONTIENE UNA O MAS UNIDADES MONOMERICAS QUE SON ANALOGOS NUCLEOTIDICOS DE FORMULA GENERAL: DONDE LOS GRUPOS B PUEDEN SER IDENTICOS O DIFERENTES, Y SON UNA BASE DE ACIDO NUCLEICO DE PIRIMIDINA O PURINA, O UN DERIVADO DE LAS MISMAS.
ES97912488T 1996-11-18 1997-11-18 Nuevos analogos de nucleotidos. Expired - Lifetime ES2192672T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP30658596 1996-11-18

Publications (1)

Publication Number Publication Date
ES2192672T3 true ES2192672T3 (es) 2003-10-16

Family

ID=17958844

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97912488T Expired - Lifetime ES2192672T3 (es) 1996-11-18 1997-11-18 Nuevos analogos de nucleotidos.

Country Status (7)

Country Link
US (1) US6043060A (es)
EP (1) EP0963997B1 (es)
AT (1) ATE232880T1 (es)
AU (1) AU4966997A (es)
DE (1) DE69719220T2 (es)
ES (1) ES2192672T3 (es)
WO (1) WO1998022489A1 (es)

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