AR083885A1 - Analogos de dipeptidos para el tratamiento de afecciones asociadas con la formacion de fibrillas amiloides - Google Patents

Analogos de dipeptidos para el tratamiento de afecciones asociadas con la formacion de fibrillas amiloides

Info

Publication number
AR083885A1
AR083885A1 ARP110104266A ARP110104266A AR083885A1 AR 083885 A1 AR083885 A1 AR 083885A1 AR P110104266 A ARP110104266 A AR P110104266A AR P110104266 A ARP110104266 A AR P110104266A AR 083885 A1 AR083885 A1 AR 083885A1
Authority
AR
Argentina
Prior art keywords
moiety
trp
analogs
dipeptides
treatment
Prior art date
Application number
ARP110104266A
Other languages
English (en)
Inventor
Anat Frydman-Marom
Yaniv Amir
Ehud Gazit
Ludmila Buzhansky
Ulrich Abel
Original Assignee
Univ Ramot
Merz Pharma Gmbh & Co Kgaa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Ramot, Merz Pharma Gmbh & Co Kgaa filed Critical Univ Ramot
Publication of AR083885A1 publication Critical patent/AR083885A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06156—Dipeptides with the first amino acid being heterocyclic and Trp-amino acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

Se presentan análogos de dipéptidos que comprenden un resto triptófano (Trp) acoplado a un resto interruptor de lámina b derivado de ácido a-aminoisobutírico (Aib). Los análogos de dipéptidos exhiben un mejorado desempeño en la inhibición de la formación de fibrilla amiloide, en comparación con los dipéptidos previamente descriptos. Se presentan además composiciones que contienen los análogos de dipéptidos, y sus usos, en el tratamiento de enfermedades y trastornos asociados con amiloide.Reivindicación 1: Un análogo de dipéptido que comprende un resto triptófano (Trp) acoplado a un resto interruptor de lámina b, con la condición de que o bien dicho resto Trp no es Trp o dicho resto interruptor de lámina b no es ácido a-aminoisobutírico (Aib) o uno de sus ésteres.
ARP110104266A 2010-11-15 2011-11-15 Analogos de dipeptidos para el tratamiento de afecciones asociadas con la formacion de fibrillas amiloides AR083885A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41348810P 2010-11-15 2010-11-15
EP10191253 2010-11-15

Publications (1)

Publication Number Publication Date
AR083885A1 true AR083885A1 (es) 2013-03-27

Family

ID=43608195

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP110104266A AR083885A1 (es) 2010-11-15 2011-11-15 Analogos de dipeptidos para el tratamiento de afecciones asociadas con la formacion de fibrillas amiloides

Country Status (14)

Country Link
US (2) US9096645B2 (es)
EP (2) EP3431489B1 (es)
JP (1) JP5911503B2 (es)
KR (1) KR20140014081A (es)
CN (1) CN103298826A (es)
AR (1) AR083885A1 (es)
AU (1) AU2011330768A1 (es)
BR (1) BR112013012033A2 (es)
CA (1) CA2817830A1 (es)
IL (1) IL226360A (es)
MX (1) MX2013005413A (es)
RU (1) RU2013126706A (es)
TW (1) TW201225972A (es)
WO (1) WO2012066549A1 (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040052928A1 (en) 2002-09-06 2004-03-18 Ehud Gazit Peptides and methods using same for diagnosing and treating amyloid-associated diseases
CA2530927A1 (en) 2003-06-30 2005-01-06 Tel Aviv University Future Technology Development L.P. Peptides antibodies directed thereagainst and methods using same for diagnosing and treating amyloid-associated diseases
US20090156471A1 (en) * 2004-07-15 2009-06-18 Ramot At Tel Aviv University Ltd. Use of anti-amyloid agents for treating and typing pathogen infections
EP2044951A1 (en) 2007-10-02 2009-04-08 Merz Pharma GmbH & Co. KGaA The use of substances for the treatment of loss of eyesight in humans with glaucoma and other degenerative eye diseases
MX2013005413A (es) 2010-11-15 2014-02-27 Univ Ramot Analogos de dipeptidos para el tratamiento de afecciones asociadas con la formacion de fibrillas amiloides.
US8912221B2 (en) * 2010-12-27 2014-12-16 Hoffmann-La Roche Inc. Biaryl amide derivatives
WO2013183048A1 (en) * 2012-06-03 2013-12-12 Ben-Gurion University Of The Negev Research And Development Authority Functionalized titanium binding peptides and implants coated with same
TW201412325A (zh) 2012-06-20 2014-04-01 梅茲製藥有限兩合公司 用於治療患有青光眼及其他退化性眼疾之人類視力喪失的間隔醫療
CN104876930B (zh) * 2014-02-27 2017-08-01 人福医药集团股份公司 合成制备化合物的方法
JP7306653B2 (ja) 2017-03-17 2023-07-11 国立大学法人千葉大学 構造強化されたＳ－ＴｕＤを用いた新規がん治療法
CN108785251B (zh) * 2018-01-23 2020-11-24 盛元医药广州有限公司 一种眼用药物组合物及其制备方法和应用
WO2020139001A1 (ko) * 2018-12-27 2020-07-02 고려대학교 산학협력단 세포 내 atp 생성 촉진을 위한 약제학적 조성물
KR102416070B1 (ko) * 2018-12-27 2022-07-06 고려대학교 산학협력단 세포 내 atp 생성 촉진을 위한 약제학적 조성물
EP3958864A1 (en) 2019-04-24 2022-03-02 Galimedix Therapeutics Inc. Indole compounds for use in neurorestoration
TWI775154B (zh) * 2019-09-23 2022-08-21 美商格利麥迪克斯治療公司 (r)-2-[2-胺基-3-(吲哚-3-基)丙醯基胺基]-2-甲基丙酸之新穎多晶型及其用途

Family Cites Families (85)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE638366A (es) 1963-10-09
NL154600B (nl) 1971-02-10 1977-09-15 Organon Nv Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen.
NL154598B (nl) 1970-11-10 1977-09-15 Organon Nv Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking.
NL154599B (nl) 1970-12-28 1977-09-15 Organon Nv Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen, alsmede testverpakking.
US3901654A (en) 1971-06-21 1975-08-26 Biological Developments Receptor assays of biologically active compounds employing biologically specific receptors
US3853987A (en) 1971-09-01 1974-12-10 W Dreyer Immunological reagent and radioimmuno assay
US3867517A (en) 1971-12-21 1975-02-18 Abbott Lab Direct radioimmunoassay for antigens and their antibodies
NL171930C (nl) 1972-05-11 1983-06-01 Akzo Nv Werkwijze voor het aantonen en bepalen van haptenen, alsmede testverpakkingen.
US3850578A (en) 1973-03-12 1974-11-26 H Mcconnell Process for assaying for biologically active molecules
US3935074A (en) 1973-12-17 1976-01-27 Syva Company Antibody steric hindrance immunoassay with two antibodies
US3996345A (en) 1974-08-12 1976-12-07 Syva Company Fluorescence quenching with immunological pairs in immunoassays
US4034074A (en) 1974-09-19 1977-07-05 The Board Of Trustees Of Leland Stanford Junior University Universal reagent 2-site immunoradiometric assay using labelled anti (IgG)
US3984533A (en) 1975-11-13 1976-10-05 General Electric Company Electrophoretic method of detecting antigen-antibody reaction
US4098876A (en) 1976-10-26 1978-07-04 Corning Glass Works Reverse sandwich immunoassay
PH14917A (en) 1978-10-23 1982-01-29 Abbott Lab Anti-bacterial peptide
US4879219A (en) 1980-09-19 1989-11-07 General Hospital Corporation Immunoassay utilizing monoclonal high affinity IgM antibodies
DE3233679A1 (de) 1981-12-08 1984-03-08 Wilhelm Dr.med. 8900 Augsburg Meyer-Glauner Carrier-tripeptid mit antifungischer wirksamkeit
JPS5944313A (ja) 1982-09-07 1984-03-12 Yakult Honsha Co Ltd 抗菌性組成物
JPS6040061A (ja) 1983-08-12 1985-03-02 ユニチカ株式会社 抗菌剤徐放性導尿カテ−テル
US4626540A (en) 1983-11-08 1986-12-02 Warner-Lambert Company Substituted 1-amino-4-nitro-acridinones and methods of treating bacterial infections and leukemia with them
DE3412445C2 (de) 1984-03-31 1986-10-30 Wilhelm Dr. 7400 Tübingen Meyer-Glauner Tripeptid und dieses enthaltende antifungische Mittel
US5011771A (en) 1984-04-12 1991-04-30 The General Hospital Corporation Multiepitopic immunometric assay
US4666828A (en) 1984-08-15 1987-05-19 The General Hospital Corporation Test for Huntington's disease
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4801531A (en) 1985-04-17 1989-01-31 Biotechnology Research Partners, Ltd. Apo AI/CIII genomic polymorphisms predictive of atherosclerosis
DE122007000007I1 (de) 1986-04-09 2007-05-16 Genzyme Corp Genetisch transformierte Tiere, die ein gewünschtes Protein in Milch absondern
JPS6344895A (ja) 1986-08-13 1988-02-25 Kyowa Hakko Kogyo Co Ltd 抗アミロイドａ蛋白質単クロ−ン性抗体
US4873316A (en) 1987-06-23 1989-10-10 Biogen, Inc. Isolation of exogenous recombinant proteins from the milk of transgenic mammals
US4970233A (en) 1987-08-04 1990-11-13 Mchugh John E Treatment of Acquired Immunodeficiency Syndrome (AIDS) HTLV-111/LAV infections and Acquired Immunodeficiency Syndroms (AIDS) Related Complex (ARC)
US5272057A (en) 1988-10-14 1993-12-21 Georgetown University Method of detecting a predisposition to cancer by the use of restriction fragment length polymorphism of the gene for human poly (ADP-ribose) polymerase
JPH02295923A (ja) 1989-05-10 1990-12-06 Taiyo Kagaku Co Ltd 腸内クロストリジウム属細菌の増殖阻害剤
US5192659A (en) 1989-08-25 1993-03-09 Genetype Ag Intron sequence analysis method for detection of adjacent and remote locus alleles as haplotypes
IT1237472B (it) 1989-10-04 1993-06-07 Polifarma Spa Derivati di acido 3-indolpiruvico, loro procedimento di produzione ed impiego terapeutico.
US5593967A (en) * 1990-08-31 1997-01-14 Warner-Lambert Company Cholecystokinin antagonists, their preparation and therapeutic use
WO1992019253A1 (en) 1991-04-24 1992-11-12 Warner-Lambert Company CCK ANALOGS CONTAINING α-SUBSTITUTED AMINO ACIDS
US5556744A (en) 1992-05-29 1996-09-17 The Trustees Of The University Of Pennsylvania Methods and compositions for diagnosing and treating certain HIV infected patients
US5281521A (en) 1992-07-20 1994-01-25 The Trustees Of The University Of Pennsylvania Modified avidin-biotin technique
BR9306984A (pt) 1992-08-27 1999-01-12 Deakin Res Ltd Análogo de antígeno de peptídeo de um antígeno de peptídeo nativo vacina anticorpo processo para vacinar um hospedeiro necessitando deste tratamento estojo diagnóstico processos para preparar um análogo de um antiígeno de um antígeno de peptídeo nativo para preparar uma vacina para analisar uma amostra para um antígeno de peptídeo nativo e para analisar uma amostra para um anticorpo
AU7261994A (en) 1993-07-19 1995-02-20 Resolution Pharmaceuticals Inc. Hydrazino-type radionuclide chelators having an n3s configuration
EP0635379B1 (en) 1993-07-22 1997-06-18 Ricoh Company, Ltd Image-bearing member and method for recycling the same
US5470951A (en) 1993-09-29 1995-11-28 City Of Hope Peptides for antagonizing the effects of amyloid βprotein
US6303567B1 (en) 1995-03-14 2001-10-16 Praecis Pharmaceuticals, Inc . Modulators of β-amyloid peptide aggregation comprising D-amino acids
WO1996028471A1 (en) 1995-03-14 1996-09-19 Praecis Pharmaceuticals Incorporated Modulators of amyloid aggregation
US5948763A (en) 1995-06-07 1999-09-07 New York University Peptides and pharmaceutical compositions thereof for treatment of disorders or diseases associated with abnormal protein folding into amyloid or amyloid-like deposits
WO1997016191A1 (en) 1995-11-02 1997-05-09 Warner-Lambert Company Inhibition of amyloidosis by 9-acridinones
US5688561A (en) 1996-04-16 1997-11-18 Kabushiki Kaisha Nippankenkyusho Coating method
US6610478B1 (en) 1996-08-16 2003-08-26 Yale University Phenotypic conversion of cells mediated by external guide sequences
US6503881B2 (en) 1996-08-21 2003-01-07 Micrologix Biotech Inc. Compositions and methods for treating infections using cationic peptides alone or in combination with antibiotics
DK0929574T3 (da) 1996-08-27 2005-10-31 Praecis Pharm Inc Modulatorer af beta-amyloidpeptidaggregering, som omfatter D-aminosyrer
US6617114B1 (en) 1996-10-31 2003-09-09 Karo Bio Ab Identification of drug complementary combinatorial libraries
CA2271291A1 (en) 1996-11-06 1998-05-14 The Government Of The United States Of America, Represented By The Secre Tary, Department Of Health And Human Services Protease-activatable pseudomonas exotoxin a-like proproteins
DE19725619A1 (de) 1997-06-17 1998-12-24 Fraunhofer Ges Forschung Peptide als Agonisten und/oder Inhibitoren der Amyloidbildung und Zytotoxizität sowie der Verwendung bei Alzheimer'schen Krankheit, beim Typ II Diabetes mellitus und bei spongiformen Encephalopathien
TWI239847B (en) 1997-12-02 2005-09-21 Elan Pharm Inc N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease
JP2002500035A (ja) 1998-01-07 2002-01-08 ヒューマン ジノーム サイエンシーズ， インコーポレイテッド ３６個のヒト分泌タンパク質
JP2000193661A (ja) 1998-12-25 2000-07-14 Tokyo Rika Kikai Kk 痴呆症の検査方法
TWI243672B (en) 1999-06-01 2005-11-21 Astrazeneca Ab New use of compounds as antibacterial agents
MXPA02001349A (es) 1999-08-09 2002-07-22 Tripep Ab Inhibidores de la polimerizacion de proteinas y metodos de uso.
WO2001016312A2 (en) 1999-08-31 2001-03-08 Ribozyme Pharmaceuticals, Inc. Nucleic acid based modulators of gene expression
US6294525B1 (en) * 1999-09-01 2001-09-25 Molecumetics Ltd. Reverse-turn mimetics and methods relating thereto
CA2383172A1 (en) 1999-09-22 2001-03-29 The Government Of The United States Of America Utilization of fprl1 as a functional receptor by serum amyloid a (saa)
US6689753B1 (en) 1999-11-05 2004-02-10 Axonyx, Inc. β sheet breaker peptide analogs that inhibit β pleated sheet formation in amyloid β-peptide
EP1286590A4 (en) 1999-11-05 2005-05-11 Axonyx Inc PEPTIDE ANALOGUES AND MIMETICS MAY BE USED IN VIVO TO TREAT DISEASES ASSOCIATED WITH AMYLOID OR PSEUDO-AMYLOID PROTEIN ABNORMAL REPLIAGE OR THEIR PATHOLOGICAL PRECURSOR RICH IN BETA-LEAF
JP2003516151A (ja) 1999-11-29 2003-05-13 エイブイアイ バイオファーマ， インコーポレイテッド 細菌１６Ｓおよび２３ＳｒＲＮＡに標的化された、荷電していないアンチセンスオリゴヌクレオチド、ならびにその使用
WO2001045726A2 (en) 1999-12-21 2001-06-28 Mars, Incorporated The use of procyanidins in the modulation of cytokine gene expression and protein secretion
WO2001093836A2 (en) 2000-06-09 2001-12-13 Teni Boulikas Encapsulation of polynucleotides and drugs into targeted liposomes
DE10043282A1 (de) 2000-09-02 2002-03-28 Kurt Heininger Verwendung von Inhibitoren der Amyloid-beta-Protein-Bildung
US20030130484A1 (en) 2001-03-20 2003-07-10 Gordon David J. Inhibitors and disassemblers of fibrillogenesis
US20040052928A1 (en) 2002-09-06 2004-03-18 Ehud Gazit Peptides and methods using same for diagnosing and treating amyloid-associated diseases
AU2004203461B2 (en) 2002-01-31 2009-09-03 Tel Aviv University Future Technology Development L.P. Peptides Antibodies Directed Thereagainst and Methods Using Same for Diagnosing and Treating Amyloid-Associated Diseases
US7781396B2 (en) 2002-01-31 2010-08-24 Tel Aviv University Future Technology Development L.P. Peptides directed for diagnosis and treatment of amyloid-associated disease
CA2473987C (en) 2002-01-31 2013-11-19 Tel Aviv University Future Technology Development L.P. Peptides antibodies directed thereagainst and methods using same for diagnosing and treating amyloid-associated diseases
US20050020809A1 (en) 2002-01-31 2005-01-27 Ehud Gazit Peptides antibodies directed thereagainst and methods using same for diagnosing and treating amyloid-associated diseases
DE60321773D1 (de) 2002-03-14 2008-08-07 Ash Access Technology Inc Medizinische vorrichtungen mit antibakteriellen eigenschaften
WO2003077869A2 (en) 2002-03-15 2003-09-25 Samaritan Pharmaceuticals, Inc Neuroprotective spirostenol pharmaceutical compositions
US6803379B2 (en) 2002-06-04 2004-10-12 Jose A. Fernandez-Pol Pharmacological agents and methods of treatment that inactivate pathogenic prokaryotic and eukaryotic cells and viruses by attacking highly conserved domains in structural metalloprotein and metalloenzyme targets
WO2004091598A1 (en) 2003-04-18 2004-10-28 Institut National De La Sante Et De La Recherche Medicale (Inserm) Use of beta-aminoisobutyric acid for the treatment of diseases linked to the accumulation of triglycerides and cholesterol
CA2530927A1 (en) 2003-06-30 2005-01-06 Tel Aviv University Future Technology Development L.P. Peptides antibodies directed thereagainst and methods using same for diagnosing and treating amyloid-associated diseases
IL210418A (en) 2003-06-30 2012-10-31 Ehud Gazit Peptides for treating amyloid-associated diseases
US20090156471A1 (en) 2004-07-15 2009-06-18 Ramot At Tel Aviv University Ltd. Use of anti-amyloid agents for treating and typing pathogen infections
EP1793816B1 (en) 2004-08-19 2012-01-04 Tel Aviv University Future Technology Development L.P. Compositions for treating amyloid associated diseases
RU2008115148A (ru) 2005-10-11 2009-11-20 Ликоред Лтд. (Il) Продукты окисления каротиноидов как химиопредупреждающие и химиотерапевтические агенты
US7879212B2 (en) 2005-11-03 2011-02-01 Ramot At Tel-Aviv University Ltd. Peptide nanostructure-coated electrodes
EP2008989A1 (de) * 2007-06-26 2008-12-31 Basf Se Kontinuierliches Verfahren zur Herstellung von Neral in reiner oder angereicherter Form
EP2085120A1 (en) * 2008-02-01 2009-08-05 Merz Pharma GmbH & Co. KGaA The use of substances for the treatment of central or peripheral insulin receptor impairment and insulin resistance
MX2013005413A (es) * 2010-11-15 2014-02-27 Univ Ramot Analogos de dipeptidos para el tratamiento de afecciones asociadas con la formacion de fibrillas amiloides.

Also Published As

Publication number Publication date
KR20140014081A (ko) 2014-02-05
EP3431489A1 (en) 2019-01-23
US9096645B2 (en) 2015-08-04
US20150322110A1 (en) 2015-11-12
JP5911503B2 (ja) 2016-04-27
WO2012066549A1 (en) 2012-05-24
TW201225972A (en) 2012-07-01
JP2013544251A (ja) 2013-12-12
US9630989B2 (en) 2017-04-25
EP2640737B1 (en) 2018-08-29
AU2011330768A1 (en) 2013-05-30
IL226360A0 (en) 2013-07-31
CN103298826A (zh) 2013-09-11
CA2817830A1 (en) 2012-05-24
EP2640737A1 (en) 2013-09-25
BR112013012033A2 (pt) 2016-08-09
US20130225512A1 (en) 2013-08-29
MX2013005413A (es) 2014-02-27
RU2013126706A (ru) 2014-12-27
IL226360A (en) 2017-10-31
EP3431489B1 (en) 2020-12-23

Similar Documents

Publication Publication Date Title
AR083885A1 (es) Analogos de dipeptidos para el tratamiento de afecciones asociadas con la formacion de fibrillas amiloides
NI202100014A (es) Metodos para reducir el riesgo de eventos cardiovasculares en un sujeto
CR20110509A (es) Composicion farmaceutica
CL2012003226A1 (es) Compuestos derivados de 5-fluoro-1h-pirazolopiridina ; procedimiento de preparacion de estos; composicion framaceutica que los comprende; y su uso en el tratamiento de enfermedades cardiovasculares, sexuales y metabolicas.
UY32778A (es) Terapia de combinación para el tratamiento de la diabetes
AR087973A1 (es) Variantes del factor 21 del crecimiento de fibroblastos
NI201300130A (es) Composiciones que contienen, metodos que involucran, y usos de derivados de dolastatina unidos a aminoácidos no naturales
EA201000399A1 (ru) Композиции и способы использования проостровковых пептидов и их аналогов
EA201270225A1 (ru) СОЕДИНЕНИЯ ДЛЯ УМЕНЬШЕНИЯ ПРОДУКЦИИ β-АМИЛОИДА
AR095276A1 (es) Péptidos para el rejuvenecimiento de la piel y métodos para utilizarlos
BR112013031268A8 (pt) polipeptídeos
EA201171197A1 (ru) Замещенные производные азоантрацена, фармацевтические композиции и способы их применения
EA201300730A1 (ru) Производные индазолилтриазола
BR112012023421A2 (pt) composição farmacêutica para tratamento de aumento de pressão intraocular
CR20110255A (es) Nuevos compuestos 578
AR075442A1 (es) Derivados de aminotetralina, composiciones farmaceuticas que las contienen y sus usos en terapia
CU24037B1 (es) Dicianopiridinas alquilamino-sustituidas y sus profármacos de éster de aminoácido
CL2011001692A1 (es) Composicion farmaceutica que entrega acido butirico y glutamina directamente en el colon, para inducir la liberacion de una hormona intestinal desde celulas l del colon; su uso en diabetes tipo i o tipo ii y obesidad, entre otros.
CO2018002328A2 (es) Formulaciones que comprenden variantes de péptido natriurético de tipo c (cnp)
CO6231001A2 (es) Estabilizacion de vitamina b12
ECSP088689A (es) NOVEDOSAS 11ß-HIDROXIANDROSTA-4-EN-3-ONAS
SV2010003485A (es) Depsipeptidos ciclicos
EA201500061A1 (ru) Фармацевтическая композиция для терапии легочной формы высотной болезни, вызванной кислородным голоданием и пониженным атмосферным давлением
CO2019007409A2 (es) Derivados de la pirimidin enona tricíclica para la inhibición de rorγ y otros usos
CL2011001777A1 (es) Composicion farmaceutica que contiene aleglitazar; proceso para preparar dicha composicion farmaceutica; y su uso para el tratamiento o profilaxis de la diabetes tipo ii o enfermedades cardiovasculares.

Legal Events

Date Code Title Description
FA Abandonment or withdrawal