EP2029779A4 - Use of highly parallel snp genotyping for fetal diagnosis - Google Patents

Use of highly parallel snp genotyping for fetal diagnosis

Info

Publication number
EP2029779A4
EP2029779A4 EP20070798580 EP07798580A EP2029779A4 EP 2029779 A4 EP2029779 A4 EP 2029779A4 EP 20070798580 EP20070798580 EP 20070798580 EP 07798580 A EP07798580 A EP 07798580A EP 2029779 A4 EP2029779 A4 EP 2029779A4
Authority
EP
Grant status
Application
Patent type
Prior art keywords
use
highly parallel
snp genotyping
fetal diagnosis
parallel snp
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP20070798580
Other languages
German (de)
French (fr)
Other versions
EP2029779A2 (en )
Inventor
Roland Stoughton
Ravi Kapur
Barb Ariel Cohen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Verinata Health Inc
Original Assignee
LIVING MICROSYSTEMS INC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869Methods for sequencing
    • C12Q1/6874Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • GPHYSICS
    • G06COMPUTING; CALCULATING; COUNTING
    • G06FELECTRIC DIGITAL DATA PROCESSING
    • G06F19/00Digital computing or data processing equipment or methods, specially adapted for specific applications
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/156Polymorphic or mutational markers
EP20070798580 2006-06-14 2007-06-14 Use of highly parallel snp genotyping for fetal diagnosis Withdrawn EP2029779A4 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US80481606 true 2006-06-14 2006-06-14
US82077806 true 2006-07-28 2006-07-28
PCT/US2007/071248 WO2007147074A3 (en) 2006-06-14 2007-06-14 Use of highly parallel snp genotyping for fetal diagnosis

Publications (2)

Publication Number Publication Date
EP2029779A2 true EP2029779A2 (en) 2009-03-04
EP2029779A4 true true EP2029779A4 (en) 2010-01-20

Family

ID=38832873

Family Applications (1)

Application Number Title Priority Date Filing Date
EP20070798580 Withdrawn EP2029779A4 (en) 2006-06-14 2007-06-14 Use of highly parallel snp genotyping for fetal diagnosis

Country Status (3)

Country Link
US (6) US20080070792A1 (en)
EP (1) EP2029779A4 (en)
WO (1) WO2007147074A3 (en)

Families Citing this family (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8024128B2 (en) * 2004-09-07 2011-09-20 Gene Security Network, Inc. System and method for improving clinical decisions by aggregating, validating and analysing genetic and phenotypic data
WO2007044091A3 (en) * 2005-06-02 2007-11-15 Antoine Daridon Analysis using microfluidic partitioning devices
US8532930B2 (en) 2005-11-26 2013-09-10 Natera, Inc. Method for determining the number of copies of a chromosome in the genome of a target individual using genetic data from genetically related individuals
US10081839B2 (en) 2005-07-29 2018-09-25 Natera, Inc System and method for cleaning noisy genetic data and determining chromosome copy number
US8515679B2 (en) 2005-12-06 2013-08-20 Natera, Inc. System and method for cleaning noisy genetic data and determining chromosome copy number
US20090181421A1 (en) * 2005-07-29 2009-07-16 Ravi Kapur Diagnosis of fetal abnormalities using nucleated red blood cells
US8921102B2 (en) 2005-07-29 2014-12-30 Gpb Scientific, Llc Devices and methods for enrichment and alteration of circulating tumor cells and other particles
US20070027636A1 (en) * 2005-07-29 2007-02-01 Matthew Rabinowitz System and method for using genetic, phentoypic and clinical data to make predictions for clinical or lifestyle decisions
US20070026418A1 (en) * 2005-07-29 2007-02-01 Martin Fuchs Devices and methods for enrichment and alteration of circulating tumor cells and other particles
US10083273B2 (en) 2005-07-29 2018-09-25 Natera, Inc. System and method for cleaning noisy genetic data and determining chromosome copy number
US9424392B2 (en) 2005-11-26 2016-08-23 Natera, Inc. System and method for cleaning noisy genetic data from target individuals using genetic data from genetically related individuals
US20070178501A1 (en) * 2005-12-06 2007-08-02 Matthew Rabinowitz System and method for integrating and validating genotypic, phenotypic and medical information into a database according to a standardized ontology
US8372584B2 (en) 2006-06-14 2013-02-12 The General Hospital Corporation Rare cell analysis using sample splitting and DNA tags
US8137912B2 (en) 2006-06-14 2012-03-20 The General Hospital Corporation Methods for the diagnosis of fetal abnormalities
EP2029779A4 (en) * 2006-06-14 2010-01-20 Living Microsystems Inc Use of highly parallel snp genotyping for fetal diagnosis
WO2008098142A3 (en) * 2007-02-08 2008-11-27 Sequenom Inc Nucleic acid-based tests for rhd typing, gender determination and nucleic acid quantification
US20100112590A1 (en) 2007-07-23 2010-05-06 The Chinese University Of Hong Kong Diagnosing Fetal Chromosomal Aneuploidy Using Genomic Sequencing With Enrichment
JP5519500B2 (en) 2007-07-23 2014-06-11 ザ チャイニーズ ユニバーシティー オブ ホンコン Determination of the imbalance of the nucleic acid sequence
US20110033862A1 (en) * 2008-02-19 2011-02-10 Gene Security Network, Inc. Methods for cell genotyping
WO2009114543A3 (en) * 2008-03-11 2010-04-15 Sequenom, Inc. Nucleic acid-based tests for prenatal gender determination
JP2011520425A (en) * 2008-04-18 2011-07-21 ザ ユニバーシティー オブ テネシー リサーチ ファウンデーション The context of the single nucleotide polymorphism (snp) and resistance to immune tolerance induction
US20110092763A1 (en) * 2008-05-27 2011-04-21 Gene Security Network, Inc. Methods for Embryo Characterization and Comparison
CN104732118B (en) * 2008-08-04 2017-08-22 纳特拉公司 Allele calling and called ploidy method
US8476013B2 (en) * 2008-09-16 2013-07-02 Sequenom, Inc. Processes and compositions for methylation-based acid enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses
US8962247B2 (en) * 2008-09-16 2015-02-24 Sequenom, Inc. Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non invasive prenatal diagnoses
CA2737643A1 (en) 2008-09-20 2010-03-25 Hei-Mun Fan Noninvasive diagnosis of fetal aneuploidy by sequencing
US20100304978A1 (en) * 2009-01-26 2010-12-02 David Xingfei Deng Methods and compositions for identifying a fetal cell
US20120185176A1 (en) 2009-09-30 2012-07-19 Natera, Inc. Methods for Non-Invasive Prenatal Ploidy Calling
CA2777549A1 (en) * 2009-11-12 2011-05-19 Esoterix Genetic Laboratories, Llc Copy number analysis of genetic locus
CA2785020A1 (en) 2009-12-22 2011-07-21 Sequenom, Inc. Processes and kits for identifying aneuploidy
EP2521794B1 (en) * 2010-01-08 2015-08-12 Oxford Gene Technology (Operations) Ltd Combined cgh & allele-specific hybridisation method
US9323888B2 (en) 2010-01-19 2016-04-26 Verinata Health, Inc. Detecting and classifying copy number variation
WO2011090556A1 (en) 2010-01-19 2011-07-28 Verinata Health, Inc. Methods for determining fraction of fetal nucleic acid in maternal samples
CA2786565C (en) * 2010-01-19 2017-04-25 Verinata Health, Inc. Partition defined detection methods
US9260745B2 (en) 2010-01-19 2016-02-16 Verinata Health, Inc. Detecting and classifying copy number variation
US9411937B2 (en) 2011-04-15 2016-08-09 Verinata Health, Inc. Detecting and classifying copy number variation
CA2787135A1 (en) 2010-01-21 2011-07-28 Biocep Ltd. Magnetic separation of rare cells
US20110312503A1 (en) 2010-01-23 2011-12-22 Artemis Health, Inc. Methods of fetal abnormality detection
EP2902500B1 (en) * 2011-02-09 2017-01-11 Natera, Inc. Methods for non-invasive prenatal ploidy calling
CA2821906A1 (en) 2010-12-22 2012-06-28 Natera, Inc. Methods for non-invasive prenatal paternity testing
WO2012108920A1 (en) 2011-02-09 2012-08-16 Natera, Inc Methods for non-invasive prenatal ploidy calling
EP2596127A2 (en) * 2010-07-23 2013-05-29 Esoterix Genetic Laboratories, LLC Identification of differentially represented fetal or maternal genomic regions and uses thereof
US20120034603A1 (en) 2010-08-06 2012-02-09 Tandem Diagnostics, Inc. Ligation-based detection of genetic variants
US20140342940A1 (en) 2011-01-25 2014-11-20 Ariosa Diagnostics, Inc. Detection of Target Nucleic Acids using Hybridization
US20120191367A1 (en) * 2011-01-25 2012-07-26 John Stuelpnagel Assay systems for determination of fetal copy number variation
EP2609219A4 (en) * 2010-08-24 2014-03-26 Bio Dx Inc Defining diagnostic and therapeutic targets of conserved free floating fetal dna in maternal circulating blood
US8756020B2 (en) 2011-01-25 2014-06-17 Ariosa Diagnostics, Inc. Enhanced risk probabilities using biomolecule estimations
US10131947B2 (en) 2011-01-25 2018-11-20 Ariosa Diagnostics, Inc. Noninvasive detection of fetal aneuploidy in egg donor pregnancies
US8700338B2 (en) 2011-01-25 2014-04-15 Ariosa Diagnosis, Inc. Risk calculation for evaluation of fetal aneuploidy
EP2682887A2 (en) * 2011-02-24 2014-01-08 The Chinese University Of Hong Kong Determining fetal DNA percentage for twins
EP2697392B1 (en) * 2011-04-12 2016-03-02 Verinata Health, Inc Resolving genome fractions using polymorphism counts
GB2484764B (en) 2011-04-14 2012-09-05 Verinata Health Inc Normalizing chromosomes for the determination and verification of common and rare chromosomal aneuploidies
US8450061B2 (en) 2011-04-29 2013-05-28 Sequenom, Inc. Quantification of a minority nucleic acid species
EP2561103B1 (en) * 2011-06-29 2014-08-27 BGI Diagnosis Co., Ltd. Noninvasive detection of fetal genetic abnormality
US20130040375A1 (en) 2011-08-08 2013-02-14 Tandem Diagnotics, Inc. Assay systems for genetic analysis
US8712697B2 (en) 2011-09-07 2014-04-29 Ariosa Diagnostics, Inc. Determination of copy number variations using binomial probability calculations
US9367663B2 (en) 2011-10-06 2016-06-14 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US9984198B2 (en) 2011-10-06 2018-05-29 Sequenom, Inc. Reducing sequence read count error in assessment of complex genetic variations
EP2768978B1 (en) 2011-10-18 2017-11-22 Multiplicom NV Fetal chromosomal aneuploidy diagnosis
WO2013131021A1 (en) 2012-03-02 2013-09-06 Sequenom Inc. Methods and processes for non-invasive assessment of genetic variations
US20130261984A1 (en) * 2012-03-30 2013-10-03 Illumina, Inc. Methods and systems for determining fetal chromosomal abnormalities
US9920361B2 (en) 2012-05-21 2018-03-20 Sequenom, Inc. Methods and compositions for analyzing nucleic acid
US9840732B2 (en) 2012-05-21 2017-12-12 Fluidigm Corporation Single-particle analysis of particle populations
US9193992B2 (en) * 2012-06-05 2015-11-24 Agilent Technologies, Inc. Method for determining ploidy of a cell
JP2015522293A (en) 2012-07-19 2015-08-06 アリオサ ダイアグノスティックス インコーポレイテッドAriosa Diagnostics,Inc. Detection of genetic variants based on multiplexing continuous ligation
US9994897B2 (en) 2013-03-08 2018-06-12 Ariosa Diagnostics, Inc. Non-invasive fetal sex determination
WO2014139477A1 (en) 2013-03-15 2014-09-18 The Chinese University Of Hong Kong Determining fetal genomes for multiple fetus pregnancies
WO2015048535A1 (en) 2013-09-27 2015-04-02 Natera, Inc. Prenatal diagnostic resting standards
US9677118B2 (en) 2014-04-21 2017-06-13 Natera, Inc. Methods for simultaneous amplification of target loci
US10011870B2 (en) 2016-12-07 2018-07-03 Natera, Inc. Compositions and methods for identifying nucleic acid molecules

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004029221A2 (en) * 2002-09-27 2004-04-08 The General Hospital Corporation Microfluidic device for cell separation and uses thereof
US20060121452A1 (en) * 2002-05-08 2006-06-08 Ravgen, Inc. Methods for detection of genetic disorders

Family Cites Families (143)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4508625A (en) * 1982-10-18 1985-04-02 Graham Marshall D Magnetic separation using chelated magnetic ions
US4683202B1 (en) * 1985-03-28 1990-11-27 Cetus Corp
US5164598A (en) * 1985-08-05 1992-11-17 Biotrack Capillary flow device
US4800149A (en) * 1986-10-10 1989-01-24 The Mead Corporation Photohardenable compositions containing a dye borate complex and photosensitive materials employing the same
US7115709B1 (en) * 1986-01-16 2006-10-03 The Regents Of The University Of California Methods of staining target chromosomal DNA employing high complexity nucleic acid probes
US5641628A (en) * 1989-11-13 1997-06-24 Children's Medical Center Corporation Non-invasive method for isolation and detection of fetal DNA
US6176962B1 (en) * 1990-02-28 2001-01-23 Aclara Biosciences, Inc. Methods for fabricating enclosed microchannel structures
US5486335A (en) * 1992-05-01 1996-01-23 Trustees Of The University Of Pennsylvania Analysis based on flow restriction
US5726026A (en) * 1992-05-01 1998-03-10 Trustees Of The University Of Pennsylvania Mesoscale sample preparation device and systems for determination and processing of analytes
US5296375A (en) * 1992-05-01 1994-03-22 Trustees Of The University Of Pennsylvania Mesoscale sperm handling devices
US5637469A (en) * 1992-05-01 1997-06-10 Trustees Of The University Of Pennsylvania Methods and apparatus for the detection of an analyte utilizing mesoscale flow systems
US5498392A (en) * 1992-05-01 1996-03-12 Trustees Of The University Of Pennsylvania Mesoscale polynucleotide amplification device and method
US5629147A (en) * 1992-07-17 1997-05-13 Aprogenex, Inc. Enriching and identifying fetal cells in maternal blood for in situ hybridization
WO1994003638A1 (en) * 1992-07-30 1994-02-17 Applied Biosystems, Inc. Method of detecting aneuploidy by amplified short tandem repeats
US5427663A (en) * 1993-06-08 1995-06-27 British Technology Group Usa Inc. Microlithographic array for macromolecule and cell fractionation
US6027923A (en) * 1993-07-23 2000-02-22 Bio-Rad Laboratories, Inc. Linked linear amplification of nucleic acids
US5962332A (en) * 1994-03-17 1999-10-05 University Of Massachusetts Detection of trinucleotide repeats by in situ hybridization
US5840502A (en) * 1994-08-31 1998-11-24 Activated Cell Therapy, Inc. Methods for enriching specific cell-types by density gradient centrifugation
US5707799A (en) * 1994-09-30 1998-01-13 Abbott Laboratories Devices and methods utilizing arrays of structures for analyte capture
US5662813A (en) * 1994-10-21 1997-09-02 Bioseparations, Inc. Method for separation of nucleated fetal erythrocytes from maternal blood samples
US5750339A (en) * 1994-11-30 1998-05-12 Thomas Jefferson University Methods for identifying fetal cells
US5709943A (en) * 1995-05-04 1998-01-20 Minnesota Mining And Manufacturing Company Biological adsorption supports
US5715946A (en) * 1995-06-07 1998-02-10 Reichenbach; Steven H. Method and apparatus for sorting particles suspended in a fluid
US5639669A (en) * 1995-06-07 1997-06-17 Ledley; Robert Separation of fetal cells from maternal blood
US6190870B1 (en) * 1995-08-28 2001-02-20 Amcell Corporation Efficient enrichment and detection of disseminated tumor cells
EP0920627B1 (en) * 1996-06-07 2004-05-12 Immunivest Corporation Magnetic separation employing external and internal gradients
US6074827A (en) * 1996-07-30 2000-06-13 Aclara Biosciences, Inc. Microfluidic method for nucleic acid purification and processing
US6100029A (en) * 1996-08-14 2000-08-08 Exact Laboratories, Inc. Methods for the detection of chromosomal aberrations
US5670325A (en) * 1996-08-14 1997-09-23 Exact Laboratories, Inc. Method for the detection of clonal populations of transformed cells in a genomically heterogeneous cellular sample
US6300077B1 (en) * 1996-08-14 2001-10-09 Exact Sciences Corporation Methods for the detection of nucleic acids
GB9620209D0 (en) * 1996-09-27 1996-11-13 Cemu Bioteknik Ab Method of sequencing DNA
US5962234A (en) * 1997-10-20 1999-10-05 Applied Imaging Corporation Use of anti-embryonic epsilon hemoglobin antibodies to identify fetal cells
GB9704444D0 (en) * 1997-03-04 1997-04-23 Isis Innovation Non-invasive prenatal diagnosis
US6143496A (en) * 1997-04-17 2000-11-07 Cytonix Corporation Method of sampling, amplifying and quantifying segment of nucleic acid, polymerase chain reaction assembly having nanoliter-sized sample chambers, and method of filling assembly
US6566101B1 (en) * 1997-06-16 2003-05-20 Anthony P. Shuber Primer extension methods for detecting nucleic acids
US6368871B1 (en) * 1997-08-13 2002-04-09 Cepheid Non-planar microstructures for manipulation of fluid samples
US5842787A (en) * 1997-10-09 1998-12-01 Caliper Technologies Corporation Microfluidic systems incorporating varied channel dimensions
US6111096A (en) * 1997-10-31 2000-08-29 Bbi Bioseq, Inc. Nucleic acid isolation and purification
US6197523B1 (en) * 1997-11-24 2001-03-06 Robert A. Levine Method for the detection, identification, enumeration and confirmation of circulating cancer and/or hematologic progenitor cells in whole blood
GB9805918D0 (en) * 1998-03-19 1998-05-13 Nycomed Amersham Plc Sequencing by hybridisation
US6200765B1 (en) * 1998-05-04 2001-03-13 Pacific Northwest Cancer Foundation Non-invasive methods to detect prostate cancer
US20030022207A1 (en) * 1998-10-16 2003-01-30 Solexa, Ltd. Arrayed polynucleotides and their use in genome analysis
FR2782730B1 (en) * 1998-08-25 2002-05-17 Biocom Sa Method for cell separation for the isolation of pathogenic cells, including rare cancerous, equipment and reagent for the implementation of the method and application of the method
DE69900949T2 (en) * 1998-09-18 2002-10-02 Micromet Ag Dns amplification from single cells
US6656697B1 (en) * 1998-09-28 2003-12-02 Lifescan, Inc. Diagnostics based on tetrazolium compounds
US6858439B1 (en) * 1999-03-15 2005-02-22 Aviva Biosciences Compositions and methods for separation of moieties on chips
US6511967B1 (en) * 1999-04-23 2003-01-28 The General Hospital Corporation Use of an internalizing transferrin receptor to image transgene expression
US7056661B2 (en) * 1999-05-19 2006-06-06 Cornell Research Foundation, Inc. Method for sequencing nucleic acid molecules
US6440706B1 (en) * 1999-08-02 2002-08-27 Johns Hopkins University Digital amplification
US6613581B1 (en) * 1999-08-26 2003-09-02 Caliper Technologies Corp. Microfluidic analytic detection assays, devices, and integrated systems
US7244559B2 (en) * 1999-09-16 2007-07-17 454 Life Sciences Corporation Method of sequencing a nucleic acid
EP1218547A4 (en) * 1999-10-15 2005-04-20 Ventana Med Syst Inc Method of detecting single gene copies in-situ
US6361958B1 (en) * 1999-11-12 2002-03-26 Motorola, Inc. Biochannel assay for hybridization with biomaterial
WO2001075171B1 (en) * 2000-04-03 2003-02-06 Corixa Corp Methods, compositions and kits for the detection and monitoring of breast cancer
US6984522B2 (en) * 2000-08-03 2006-01-10 Regents Of The University Of Michigan Isolation and use of solid tumor stem cells
US20040005582A1 (en) * 2000-08-10 2004-01-08 Nanobiodynamics, Incorporated Biospecific desorption microflow systems and methods for studying biospecific interactions and their modulators
US6689615B1 (en) * 2000-10-04 2004-02-10 James Murto Methods and devices for processing blood samples
WO2002065515A3 (en) * 2001-02-14 2003-03-06 Stc Unm Nanostructured devices for separation and analysis
GB0104690D0 (en) * 2001-02-26 2001-04-11 Cytogenetic Dna Services Ltd Diagnostic test
EP1377811B1 (en) * 2001-04-03 2008-07-16 Micronics, Inc. Split focusing cytometer
EP1384022A4 (en) * 2001-04-06 2004-08-04 California Inst Of Techn Nucleic acid amplification utilizing microfluidic devices
US20020155587A1 (en) * 2001-04-20 2002-10-24 Sequenom, Inc. System and method for testing a biological sample
US7288405B2 (en) * 2001-04-25 2007-10-30 Cornell Research Foundation, Inc. Devices and methods for pharmacokinetic-based cell culture system
US20030007894A1 (en) * 2001-04-27 2003-01-09 Genoptix Methods and apparatus for use of optical forces for identification, characterization and/or sorting of particles
FR2824144B1 (en) * 2001-04-30 2004-09-17 Metagenex S A R L Methode prenatal diagnosis of fetal cell insulated from maternal blood
US20020166760A1 (en) * 2001-05-11 2002-11-14 Prentiss Mara G. Micromagentic systems and methods for microfluidics
DE10127079A1 (en) * 2001-06-02 2002-12-12 Ulrich Pachmann A method for quantitative detection of vital epithelial tumor cells in a body fluid
US20050037388A1 (en) * 2001-06-22 2005-02-17 University Of Geneva Method for detecting diseases caused by chromosomal imbalances
US7993908B2 (en) * 2001-07-17 2011-08-09 Parsortix, Inc. Microstructure for particle and cell separation, identification, sorting, and manipulation
US6783928B2 (en) * 2001-07-17 2004-08-31 Georgi Hvichia Microstructures for cell proliferation assays and semen analysis
US20060008807A1 (en) * 2002-08-23 2006-01-12 O'hara Shawn M Multiparameter analysis of comprehensive nucleic acids and morphological features on the same sample
US6927028B2 (en) * 2001-08-31 2005-08-09 Chinese University Of Hong Kong Non-invasive methods for detecting non-host DNA in a host using epigenetic differences between the host and non-host DNA
US7507528B2 (en) * 2001-09-06 2009-03-24 Adnagen Ag Method and diagnosis kit for selecting and or qualitative and/or quantitative detection of cells
DE10143776A1 (en) * 2001-09-06 2003-04-03 Adnagen Ag Selection and determination of specific cells, useful particularly for diagnosis and monitoring of tumors, by antibody-mediated selection then detecting specific mRNA
US20070042360A1 (en) * 2001-09-17 2007-02-22 Eos Biotechnology, Inc. Methods of diagnosis of cancer, compositions and methods of screening for modulators of cancer
US7166443B2 (en) * 2001-10-11 2007-01-23 Aviva Biosciences Corporation Methods, compositions, and automated systems for separating rare cells from fluid samples
US7691333B2 (en) * 2001-11-30 2010-04-06 Fluidigm Corporation Microfluidic device and methods of using same
WO2003068672A3 (en) * 2002-02-12 2004-07-15 Kionix Inc Fabrication of ultra-shallow channels for microfluidic devices and systems
EP1474772A4 (en) * 2002-02-14 2005-11-09 Immunivest Corp Methods and algorithms for cell enumeration in a low-cost cytometer
US6977162B2 (en) * 2002-03-01 2005-12-20 Ravgen, Inc. Rapid analysis of variations in a genome
US7442506B2 (en) * 2002-05-08 2008-10-28 Ravgen, Inc. Methods for detection of genetic disorders
US7141369B2 (en) * 2002-04-25 2006-11-28 Semibio Technology, Inc. Measuring cellular metabolism of immobilized cells
US7272252B2 (en) * 2002-06-12 2007-09-18 Clarient, Inc. Automated system for combining bright field and fluorescent microscopy
US7214348B2 (en) * 2002-07-26 2007-05-08 Applera Corporation Microfluidic size-exclusion devices, systems, and methods
US7150834B2 (en) * 2003-07-31 2006-12-19 Arryx, Inc. Multiple laminar flow-based rate zonal or isopycnic separation with holographic optical trapping of blood cells and other static components
US7106905B2 (en) * 2002-08-23 2006-09-12 Hewlett-Packard Development Company, L.P. Systems and methods for processing text-based electronic documents
US20040043506A1 (en) * 2002-08-30 2004-03-04 Horst Haussecker Cascaded hydrodynamic focusing in microfluidic channels
WO2004037374A3 (en) * 2002-10-23 2004-10-14 Univ Princeton Method for continuous particle separation using obstacle arrays asymmetrically aligned to fields
EP1578994A2 (en) * 2002-11-11 2005-09-28 Affymetrix, Inc. Methods for identifying dna copy number changes
US7704687B2 (en) * 2002-11-15 2010-04-27 The Johns Hopkins University Digital karyotyping
US20060000772A1 (en) * 2002-11-29 2006-01-05 Toru Sano Separation apparatus and separation method
US7604965B2 (en) * 2003-04-03 2009-10-20 Fluidigm Corporation Thermal reaction device and method for using the same
US7476363B2 (en) * 2003-04-03 2009-01-13 Fluidigm Corporation Microfluidic devices and methods of using same
US20070042339A1 (en) * 2003-08-08 2007-02-22 Massachusetts General Hospital Preservation of biomaterials with transported preservation agents
US20050266417A1 (en) * 2003-09-12 2005-12-01 Francis Barany Methods for identifying target nucleic acid molecules
JP2007508017A (en) * 2003-10-08 2007-04-05 ザ トラスティーズ オブ ボストン ユニバーシティ Methods for prenatal diagnosis of chromosomal abnormalities
EP1524321B2 (en) * 2003-10-16 2014-07-23 Sequenom, Inc. Non-invasive detection of fetal genetic traits
WO2005039389A3 (en) * 2003-10-22 2005-11-24 454 Corp Sequence-based karyotyping
US7169560B2 (en) * 2003-11-12 2007-01-30 Helicos Biosciences Corporation Short cycle methods for sequencing polynucleotides
US20060046258A1 (en) * 2004-02-27 2006-03-02 Lapidus Stanley N Applications of single molecule sequencing
CA2602493C (en) * 2005-03-23 2015-03-17 Velocys, Inc. Surface features in microprocess technology
US7622281B2 (en) * 2004-05-20 2009-11-24 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for clonal amplification of nucleic acid
US20060024711A1 (en) * 2004-07-02 2006-02-02 Helicos Biosciences Corporation Methods for nucleic acid amplification and sequence determination
US20060024678A1 (en) * 2004-07-28 2006-02-02 Helicos Biosciences Corporation Use of single-stranded nucleic acid binding proteins in sequencing
US20060051265A1 (en) * 2004-09-08 2006-03-09 Health Research, Inc. Apparatus and method for sorting microstructures in a fluid medium
CN101137760B (en) * 2005-03-18 2011-01-26 香港中文大学;波士顿大学 Method for the detection of chromosomal aneuploidies
EP2612928A3 (en) * 2005-03-18 2013-09-11 The Chinese University Of Hong Kong Markers for prenatal diagnosis and monitoring
US20070196820A1 (en) * 2005-04-05 2007-08-23 Ravi Kapur Devices and methods for enrichment and alteration of cells and other particles
US20060223178A1 (en) * 2005-04-05 2006-10-05 Tom Barber Devices and methods for magnetic enrichment of cells and other particles
US20070026414A1 (en) * 2005-07-29 2007-02-01 Martin Fuchs Devices and methods for enrichment and alteration of circulating tumor cells and other particles
US20070026413A1 (en) * 2005-07-29 2007-02-01 Mehmet Toner Devices and methods for enrichment and alteration of circulating tumor cells and other particles
US20070026419A1 (en) * 2005-07-29 2007-02-01 Martin Fuchs Devices and methods for enrichment and alteration of circulating tumor cells and other particles
US20070026415A1 (en) * 2005-07-29 2007-02-01 Martin Fuchs Devices and methods for enrichment and alteration of circulating tumor cells and other particles
US20070026417A1 (en) * 2005-07-29 2007-02-01 Martin Fuchs Devices and methods for enrichment and alteration of circulating tumor cells and other particles
US20070026418A1 (en) * 2005-07-29 2007-02-01 Martin Fuchs Devices and methods for enrichment and alteration of circulating tumor cells and other particles
US10083273B2 (en) * 2005-07-29 2018-09-25 Natera, Inc. System and method for cleaning noisy genetic data and determining chromosome copy number
US20070027636A1 (en) * 2005-07-29 2007-02-01 Matthew Rabinowitz System and method for using genetic, phentoypic and clinical data to make predictions for clinical or lifestyle decisions
US8921102B2 (en) * 2005-07-29 2014-12-30 Gpb Scientific, Llc Devices and methods for enrichment and alteration of circulating tumor cells and other particles
US20070026416A1 (en) * 2005-07-29 2007-02-01 Martin Fuchs Devices and methods for enrichment and alteration of circulating tumor cells and other particles
US8173413B2 (en) * 2005-08-11 2012-05-08 University Of Washington Separation and concentration of biological cells and biological particles using a one-dimensional channel
US20070037173A1 (en) * 2005-08-12 2007-02-15 Allard Jeffrey W Circulating tumor cells (CTC's): early assessment of time to progression, survival and response to therapy in metastatic cancer patients
EP1758193A1 (en) * 2005-08-22 2007-02-28 LG Electronics Inc. Fuel cell with water-cooled power converter
US20070059774A1 (en) * 2005-09-15 2007-03-15 Michael Grisham Kits for Prenatal Testing
US20070059716A1 (en) * 2005-09-15 2007-03-15 Ulysses Balis Methods for detecting fetal abnormality
US20070059680A1 (en) * 2005-09-15 2007-03-15 Ravi Kapur System for cell enrichment
US20070059683A1 (en) * 2005-09-15 2007-03-15 Tom Barber Veterinary diagnostic system
US20070059719A1 (en) * 2005-09-15 2007-03-15 Michael Grisham Business methods for prenatal Diagnosis
US20070059781A1 (en) * 2005-09-15 2007-03-15 Ravi Kapur System for size based separation and analysis
CA2647793C (en) * 2006-02-28 2016-07-05 University Of Louisville Research Foundation Detecting fetal chromosomal abnormalities using tandem single nucleotide polymorphisms
WO2007112418A3 (en) * 2006-03-28 2008-10-23 Baylor College Medicine Screening for down syndrome
EP2040843A4 (en) * 2006-06-01 2014-04-02 Univ Princeton Apparatus and method for continuous particle separation
EP2029779A4 (en) * 2006-06-14 2010-01-20 Living Microsystems Inc Use of highly parallel snp genotyping for fetal diagnosis
US8137912B2 (en) * 2006-06-14 2012-03-20 The General Hospital Corporation Methods for the diagnosis of fetal abnormalities
US8372584B2 (en) * 2006-06-14 2013-02-12 The General Hospital Corporation Rare cell analysis using sample splitting and DNA tags
WO2009035447A1 (en) * 2006-06-14 2009-03-19 Living Microsystems, Inc. Diagnosis of fetal abnormalities by comparative genomic hybridization analysis
US20080050739A1 (en) * 2006-06-14 2008-02-28 Roland Stoughton Diagnosis of fetal abnormalities using polymorphisms including short tandem repeats
CN101501251A (en) * 2006-06-16 2009-08-05 塞昆纳姆股份有限公司 Methods and compositions for the amplification, detection and quantification of nucleic acid from a sample
WO2008098142A3 (en) * 2007-02-08 2008-11-27 Sequenom Inc Nucleic acid-based tests for rhd typing, gender determination and nucleic acid quantification
WO2008135986A3 (en) * 2007-05-04 2010-02-25 Genes-It Software Ltd. System, method and device for comprehensive individualized genetic information or genetic counseling
JP5519500B2 (en) * 2007-07-23 2014-06-11 ザ チャイニーズ ユニバーシティー オブ ホンコン Determination of the imbalance of the nucleic acid sequence
US20090053719A1 (en) * 2007-08-03 2009-02-26 The Chinese University Of Hong Kong Analysis of nucleic acids by digital pcr
US8481699B2 (en) * 2009-07-14 2013-07-09 Academia Sinica Multiplex barcoded Paired-End ditag (mbPED) library construction for ultra high throughput sequencing
WO2011090556A1 (en) * 2010-01-19 2011-07-28 Verinata Health, Inc. Methods for determining fraction of fetal nucleic acid in maternal samples

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060121452A1 (en) * 2002-05-08 2006-06-08 Ravgen, Inc. Methods for detection of genetic disorders
WO2004029221A2 (en) * 2002-09-27 2004-04-08 The General Hospital Corporation Microfluidic device for cell separation and uses thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ADINOLFI M ET AL: "Rapid detection of aneuploidies by microsatellite and the quantitative fluorescent polymerase chain reaction", PRENATAL DIAGNOSIS, CHICHESTER, SUSSEX, GB, vol. 17, no. 13, 1 December 1997 (1997-12-01), pages 1299 - 1311, XP002210676, ISSN: 0197-3851 *
HAMABE J-I ET AL: "MOLECULAR STUDY OF THE PRADER-WILLI SYNDROME DELETION RFLP AND PHENOTYPE ANALYSES OF 50 PATIENTS", AMERICAN JOURNAL OF MEDICAL GENETICS, vol. 41, no. 1, 1991, pages 54 - 63, XP002553197, ISSN: 0148-7299 *

Also Published As

Publication number Publication date Type
US20080070792A1 (en) 2008-03-20 application
US20140106975A1 (en) 2014-04-17 application
EP2029779A2 (en) 2009-03-04 application
US20100291572A1 (en) 2010-11-18 application
WO2007147074A3 (en) 2008-05-08 application
WO2007147074A2 (en) 2007-12-21 application
US20110003293A1 (en) 2011-01-06 application
US20130210644A1 (en) 2013-08-15 application
US20090291443A1 (en) 2009-11-26 application

Similar Documents

Publication Publication Date Title
GB2464751B (en) Scalpel
GB2442441B (en) Surgical instrument
GB2469839B (en) Medical instrument
GB0618033D0 (en) Electrochemical synthesis of composites
GB2458124B (en) Indicator
EP2078497B8 (en) Medical instrument

Legal Events

Date Code Title Description
17P Request for examination filed

Effective date: 20081231

AK Designated contracting states:

Kind code of ref document: A2

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR

AX Request for extension of the european patent to

Countries concerned: ALBAHRMKRS

DAX Request for extension of the european patent (to any country) deleted
A4 Despatch of supplementary search report

Effective date: 20091222

17Q First examination report

Effective date: 20100803

RAP1 Transfer of rights of an ep published application

Owner name: ARTEMIS HEALTH, INC.

RAP1 Transfer of rights of an ep published application

Owner name: VERINATA HEALTH, INC

RAP1 Transfer of rights of an ep published application

Owner name: VERINATA HEALTH, INC

18D Deemed to be withdrawn

Effective date: 20121103