ATE497774T1 - Screening kombinatorischer proteinbibliotheken mittels periplasmatischer expression - Google Patents

Screening kombinatorischer proteinbibliotheken mittels periplasmatischer expression

Info

Publication number
ATE497774T1
ATE497774T1 AT03817832T AT03817832T ATE497774T1 AT E497774 T1 ATE497774 T1 AT E497774T1 AT 03817832 T AT03817832 T AT 03817832T AT 03817832 T AT03817832 T AT 03817832T AT E497774 T1 ATE497774 T1 AT E497774T1
Authority
AT
Austria
Prior art keywords
combinatory
screening
protein libraries
periplasmatic expression
periplasmatic
Prior art date
Application number
AT03817832T
Other languages
English (en)
Inventor
Barrett Harvey
George Georgiou
Brent Iverson
Original Assignee
Univ Texas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Texas filed Critical Univ Texas
Application granted granted Critical
Publication of ATE497774T1 publication Critical patent/ATE497774T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/005—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/025—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Virology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Pathology (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AT03817832T 2002-07-15 2003-07-15 Screening kombinatorischer proteinbibliotheken mittels periplasmatischer expression ATE497774T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39605802P 2002-07-15 2002-07-15
PCT/US2003/021928 WO2005019409A2 (en) 2002-07-15 2003-07-15 Combinatorial protein library screening by periplasmic expression

Publications (1)

Publication Number Publication Date
ATE497774T1 true ATE497774T1 (de) 2011-02-15

Family

ID=34215743

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03817832T ATE497774T1 (de) 2002-07-15 2003-07-15 Screening kombinatorischer proteinbibliotheken mittels periplasmatischer expression

Country Status (9)

Country Link
US (2) US6916474B2 (de)
EP (1) EP1636561B1 (de)
JP (1) JP4570565B2 (de)
AT (1) ATE497774T1 (de)
AU (2) AU2003304195B8 (de)
CA (1) CA2501188C (de)
DE (1) DE60336023D1 (de)
DK (1) DK1636561T3 (de)
WO (1) WO2005019409A2 (de)

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US7094571B2 (en) * 2000-10-27 2006-08-22 The Board Of Regents Of The University Of Texas System Combinatorial protein library screening by periplasmic expression
US7083945B1 (en) 2000-10-27 2006-08-01 The Board Of Regents Of The University Of Texas System Isolation of binding proteins with high affinity to ligands
AU2002354047B2 (en) * 2001-11-05 2007-11-22 Board Of Regents, The University Of Texas System Recombinant antibodies for the detection and neutralization of anthrax toxin
US7601351B1 (en) 2002-06-26 2009-10-13 Human Genome Sciences, Inc. Antibodies against protective antigen
AU2003304195B8 (en) * 2002-07-15 2008-08-28 Board Of Regents, The University Of Texas System Combinatorial protein library screening by periplasmic expression
US7611866B2 (en) 2002-07-15 2009-11-03 Board Of Regents, The University Of Texas System Selection of bacterial inner-membrane anchor polypeptides
US20060246079A1 (en) 2003-11-14 2006-11-02 Morrow Phillip R Neutralizing human antibodies to anthrax toxin
US20060029947A1 (en) * 2004-03-18 2006-02-09 Board Of Regents, The University Of Texas System Combinatorial protein library screening by periplasmic expression
US20060121045A1 (en) * 2004-11-08 2006-06-08 Brent Iverson Antibody fragments for protection from pathogen infection and methods of use thereof
AU2007259329A1 (en) * 2006-05-12 2007-12-21 Farris, Darise Anthrax compositions and methods of use and production
US8420607B2 (en) * 2006-06-30 2013-04-16 University Of Georgia Research Foundation, Inc. Anthrax carbohydrates, synthesis and uses thereof
EP2044194B1 (de) 2006-06-30 2011-10-05 University Of Georgia Research Foundation, Inc. Anthrax-kohlenhydrate sowie synthese und verwendungen davon
WO2008140483A2 (en) * 2006-11-09 2008-11-20 Human Genome Sciences, Inc. Methods and antibodies for detecting protective antigen
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US7935345B2 (en) 2007-05-21 2011-05-03 Children's Hospital & Research Center At Oakland Monoclonal antibodies that specifically bind to and neutralize bacillus anthracis toxin, compositions, and methods of use
JP5514399B2 (ja) * 2007-11-02 2014-06-04 国立大学法人 岡山大学 無機硫黄化合物加水分解酵素の製造方法
JP2009122016A (ja) * 2007-11-16 2009-06-04 Kyushu Univ 判定装置、選定装置、判定方法、細胞生産方法、プログラム及び記録媒体
WO2010104115A1 (ja) * 2009-03-10 2010-09-16 独立行政法人産業技術総合研究所 膜タンパク質を特異的に認識するポリペプチドの調製方法
DK2516702T3 (en) 2009-12-23 2018-04-30 Affinity Biosciences Pty Ltd PROTEIN DISPLAY
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JP2011231092A (ja) * 2010-04-28 2011-11-17 Advance Co Ltd 作製用の抗体及び抗体作製方法
JP6013470B2 (ja) 2011-06-29 2016-10-25 アフィニティ バイオサイエンス ピーティーワイ リミテッド タンパク質ディスプレイの方法
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KR101912631B1 (ko) * 2015-12-03 2018-10-30 국민대학교산학협력단 막 단백질 제조용 융합 단백질, 발현 벡터, 및 이를 이용한 막 단백질 제조방법
US11795579B2 (en) 2017-12-11 2023-10-24 Abalone Bio, Inc. Yeast display of proteins in the periplasmic space
JP7412043B2 (ja) 2020-08-05 2024-01-12 国立研究開発法人産業技術総合研究所 標的タンパク質に作用するポリペプチドのスクリーニング方法

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Also Published As

Publication number Publication date
EP1636561B1 (de) 2011-02-09
CA2501188A1 (en) 2005-03-03
DK1636561T3 (da) 2011-05-16
JP4570565B2 (ja) 2010-10-27
EP1636561A2 (de) 2006-03-22
AU2003304195A1 (en) 2005-09-08
AU2003304195B8 (en) 2008-08-28
US20050106647A1 (en) 2005-05-19
AU2003304195B2 (en) 2008-08-07
DE60336023D1 (de) 2011-03-24
WO2005019409A2 (en) 2005-03-03
US7902344B2 (en) 2011-03-08
AU2008243161B2 (en) 2010-11-04
AU2008243161A1 (en) 2008-12-04
EP1636561A4 (de) 2008-05-28
CA2501188C (en) 2012-05-15
US6916474B2 (en) 2005-07-12
WO2005019409A3 (en) 2007-07-12
JP2006515514A (ja) 2006-06-01
US20050267294A1 (en) 2005-12-01

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