ES2185472B1 - Empleo del gen slug, o de sus productos de transcripcion o expresion, en la deteccion y/o tratamiento de celulas cancerosas. - Google Patents
Empleo del gen slug, o de sus productos de transcripcion o expresion, en la deteccion y/o tratamiento de celulas cancerosas.Info
- Publication number
- ES2185472B1 ES2185472B1 ES200100151A ES200100151A ES2185472B1 ES 2185472 B1 ES2185472 B1 ES 2185472B1 ES 200100151 A ES200100151 A ES 200100151A ES 200100151 A ES200100151 A ES 200100151A ES 2185472 B1 ES2185472 B1 ES 2185472B1
- Authority
- ES
- Spain
- Prior art keywords
- transcription
- expression products
- treatment
- slug
- detection
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/5743—Specifically defined cancers of skin, e.g. melanoma
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/57426—Specifically defined cancers leukemia
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
Abstract
Empleo del gen Slug, o de sus productos de transcripción o expresión, en la detección y/o tratamiento de células cancerosas. La expresión aberrante del gen Slug o de sus productos de transcripción o expresión permite detectar la presencia de células cancerosas, en particular, células tumorales mesenquimales, en una muestra biológica sospechosa de contener dichas células malignas. El gen Slug, o sus productos de transcripción o expresión pueden ser utilizados en el tratamiento del cáncer.
Priority Applications (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES200100151A ES2185472B1 (es) | 2001-01-23 | 2001-01-23 | Empleo del gen slug, o de sus productos de transcripcion o expresion, en la deteccion y/o tratamiento de celulas cancerosas. |
US10/466,817 US7776519B2 (en) | 2001-01-23 | 2002-01-23 | Use of the slug gene, or of the transcription or expression products thereof in the detection and/or treatment of cancerous cells |
PCT/ES2002/000026 WO2002059361A1 (es) | 2001-01-23 | 2002-01-23 | Empleo del gen slug o de sus productos de transcripcion o expresion en la deteccion y/o tratamiento de celulas cancerosas |
JP2002559843A JP2004520045A (ja) | 2001-01-23 | 2002-01-23 | 癌細胞を検出および/または治療するためにSlug遺伝子またはその遺伝子の転写もしくは発現生成物を使用する方法。 |
DE60234991T DE60234991D1 (de) | 2001-01-23 | 2002-01-23 | Verwendung des slug-gens oder der transkriptions- oder expressionsprodukte davon beim nachweis und/oder bei der behandlung von krebsartigen zellen |
AT02710865T ATE454467T1 (de) | 2001-01-23 | 2002-01-23 | Verwendung des slug-gens oder der transkriptions- oder expressionsprodukte davon beim nachweis und/oder bei der behandlung von krebsartigen zellen |
ES02710865T ES2339335T3 (es) | 2001-01-23 | 2002-01-23 | Empleo del gen slug, o de sus productos de transcripcion o expresion, en la deteccion y/o el tratamiento de celulas cancerosas. |
EP20020710865 EP1354962B1 (en) | 2001-01-23 | 2002-01-23 | Use of the slug gene or of the transcription or expression products thereof in the detection and/or treatment of cancerous cells |
ES200202634A ES2242469B1 (es) | 2001-01-23 | 2002-11-15 | Composicion farmaceutica para el tratamiento del cancer. |
ES200202633A ES2241402B1 (es) | 2001-01-23 | 2002-11-15 | Metodo para el screening in vitro de agentes antitumorales basados en la regulacion de la expresion del gen slug. |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES200100151A ES2185472B1 (es) | 2001-01-23 | 2001-01-23 | Empleo del gen slug, o de sus productos de transcripcion o expresion, en la deteccion y/o tratamiento de celulas cancerosas. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2185472A1 ES2185472A1 (es) | 2003-04-16 |
ES2185472B1 true ES2185472B1 (es) | 2004-10-16 |
Family
ID=8496481
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES200100151A Expired - Fee Related ES2185472B1 (es) | 2001-01-23 | 2001-01-23 | Empleo del gen slug, o de sus productos de transcripcion o expresion, en la deteccion y/o tratamiento de celulas cancerosas. |
ES02710865T Expired - Lifetime ES2339335T3 (es) | 2001-01-23 | 2002-01-23 | Empleo del gen slug, o de sus productos de transcripcion o expresion, en la deteccion y/o el tratamiento de celulas cancerosas. |
ES200202633A Expired - Fee Related ES2241402B1 (es) | 2001-01-23 | 2002-11-15 | Metodo para el screening in vitro de agentes antitumorales basados en la regulacion de la expresion del gen slug. |
ES200202634A Expired - Fee Related ES2242469B1 (es) | 2001-01-23 | 2002-11-15 | Composicion farmaceutica para el tratamiento del cancer. |
Family Applications After (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES02710865T Expired - Lifetime ES2339335T3 (es) | 2001-01-23 | 2002-01-23 | Empleo del gen slug, o de sus productos de transcripcion o expresion, en la deteccion y/o el tratamiento de celulas cancerosas. |
ES200202633A Expired - Fee Related ES2241402B1 (es) | 2001-01-23 | 2002-11-15 | Metodo para el screening in vitro de agentes antitumorales basados en la regulacion de la expresion del gen slug. |
ES200202634A Expired - Fee Related ES2242469B1 (es) | 2001-01-23 | 2002-11-15 | Composicion farmaceutica para el tratamiento del cancer. |
Country Status (7)
Country | Link |
---|---|
US (1) | US7776519B2 (es) |
EP (1) | EP1354962B1 (es) |
JP (1) | JP2004520045A (es) |
AT (1) | ATE454467T1 (es) |
DE (1) | DE60234991D1 (es) |
ES (4) | ES2185472B1 (es) |
WO (1) | WO2002059361A1 (es) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2195751B1 (es) | 2001-11-27 | 2005-04-01 | Universidad De Salamanca (Otri) | Mamiferos no humanos transgenicos como modelos para patologias humanas con origen en celulas stem. |
ES2253028B1 (es) * | 2003-05-30 | 2007-08-01 | Universidad De Salamanca | "empleo del gen slug, sus productos de transcripcion o expresion, y/o compuestos inhibidores o estimuladores de la expresion de slug para conferir radioresistencia o radioproteccion celular. |
ES2301268B1 (es) | 2004-10-25 | 2009-05-01 | Centro De Investigacion Biomolecular Aplicada Salamanca, S.L. | Empleo del gen slug, o de sus productos de replicacion, transcripcion o expresion, en la identificacion, diagnostico, prevencion o tratamiento de la diseminacion del cancer y/o desarrollo de metastasis. |
US20090214483A1 (en) * | 2005-06-30 | 2009-08-27 | Weinberg Robert A | Progenitor Cells and Uses Thereof |
US20110302665A1 (en) * | 2008-07-02 | 2011-12-08 | Oktay Kirak | Non-human mammals with t or b cells having predefined specificity |
KR101805181B1 (ko) | 2016-09-02 | 2017-12-07 | 충북대학교 산학협력단 | 인산화된 slug 단백질의 유사분열 세포에 대한 신규한 바이오 마커로서의 용도 |
WO2023126958A1 (en) * | 2021-12-30 | 2023-07-06 | Mestastop Solutions Private Limited | Method for producing a spontaneous metastasis model |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4965188A (en) | 1986-08-22 | 1990-10-23 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme |
US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
EP1639090A4 (en) * | 2003-06-09 | 2008-04-16 | Univ Michigan | COMPOSITIONS AND METHODS FOR TREATING AND DIAGNOSING CANCER |
-
2001
- 2001-01-23 ES ES200100151A patent/ES2185472B1/es not_active Expired - Fee Related
-
2002
- 2002-01-23 JP JP2002559843A patent/JP2004520045A/ja active Pending
- 2002-01-23 WO PCT/ES2002/000026 patent/WO2002059361A1/es active Application Filing
- 2002-01-23 ES ES02710865T patent/ES2339335T3/es not_active Expired - Lifetime
- 2002-01-23 AT AT02710865T patent/ATE454467T1/de not_active IP Right Cessation
- 2002-01-23 EP EP20020710865 patent/EP1354962B1/en not_active Expired - Lifetime
- 2002-01-23 DE DE60234991T patent/DE60234991D1/de not_active Expired - Lifetime
- 2002-01-23 US US10/466,817 patent/US7776519B2/en not_active Expired - Fee Related
- 2002-11-15 ES ES200202633A patent/ES2241402B1/es not_active Expired - Fee Related
- 2002-11-15 ES ES200202634A patent/ES2242469B1/es not_active Expired - Fee Related
Non-Patent Citations (7)
Also Published As
Publication number | Publication date |
---|---|
DE60234991D1 (de) | 2010-02-25 |
JP2004520045A (ja) | 2004-07-08 |
ES2241402A1 (es) | 2005-10-16 |
ATE454467T1 (de) | 2010-01-15 |
WO2002059361A1 (es) | 2002-08-01 |
EP1354962B1 (en) | 2010-01-06 |
ES2242469B1 (es) | 2006-07-16 |
US20060141454A1 (en) | 2006-06-29 |
ES2339335T3 (es) | 2010-05-19 |
ES2241402B1 (es) | 2007-02-16 |
US7776519B2 (en) | 2010-08-17 |
EP1354962A1 (en) | 2003-10-22 |
ES2185472A1 (es) | 2003-04-16 |
ES2242469A1 (es) | 2005-11-01 |
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