PE20221902A1 - Anticuerpos anti-e-selectina, composiciones y metodos de uso - Google Patents
Anticuerpos anti-e-selectina, composiciones y metodos de usoInfo
- Publication number
- PE20221902A1 PE20221902A1 PE2022001465A PE2022001465A PE20221902A1 PE 20221902 A1 PE20221902 A1 PE 20221902A1 PE 2022001465 A PE2022001465 A PE 2022001465A PE 2022001465 A PE2022001465 A PE 2022001465A PE 20221902 A1 PE20221902 A1 PE 20221902A1
- Authority
- PE
- Peru
- Prior art keywords
- compositions
- methods
- amino acid
- acid sequence
- selectin antibodies
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2851—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
- C07K16/2854—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72 against selectins, e.g. CD62
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/515—Complete light chain, i.e. VL + CL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
SE REFIERE A UN ANTICUERPO AISLADO, O FRAGMENTO DE FIJACION AL ANTIGENO DE ESTE, QUE SE FIJA ESPECIFICAMENTE A E-SELECTINA HUMANA EL CUAL ESTA DEFINIDO A TRAVES DE LA SECUENCIA AMINOACIDICA DE SUS 6 CDRS (acapites a-i), SECUENCIA AMINOCIDICA DE SU REGION VARIABLE (acapites j - m) Y LA SECUENCIA AMINOACIDICA COMPLETA DE CADENA PESADA Y LIGERA.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202062965688P | 2020-01-24 | 2020-01-24 | |
US202063104213P | 2020-10-22 | 2020-10-22 | |
US202063121467P | 2020-12-04 | 2020-12-04 | |
PCT/IB2021/050464 WO2021148983A1 (en) | 2020-01-24 | 2021-01-21 | Anti-e-selectin antibodies, compositions and methods of use |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20221902A1 true PE20221902A1 (es) | 2022-12-21 |
Family
ID=74236245
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2022001465A PE20221902A1 (es) | 2020-01-24 | 2021-01-21 | Anticuerpos anti-e-selectina, composiciones y metodos de uso |
Country Status (14)
Country | Link |
---|---|
US (2) | US11597770B2 (es) |
EP (1) | EP4093508A1 (es) |
JP (1) | JP7449390B2 (es) |
KR (1) | KR20220131293A (es) |
CN (1) | CN115190814A (es) |
AU (1) | AU2021210669A1 (es) |
BR (1) | BR112022014417A2 (es) |
CA (1) | CA3168704A1 (es) |
CO (1) | CO2022010244A2 (es) |
IL (1) | IL294921A (es) |
MX (1) | MX2022009130A (es) |
PE (1) | PE20221902A1 (es) |
TW (1) | TW202140558A (es) |
WO (1) | WO2021148983A1 (es) |
Family Cites Families (67)
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US4754065A (en) | 1984-12-18 | 1988-06-28 | Cetus Corporation | Precursor to nucleic acid probe |
US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
GB8601597D0 (en) | 1986-01-23 | 1986-02-26 | Wilson R H | Nucleotide sequences |
US4800159A (en) | 1986-02-07 | 1989-01-24 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences |
IL85035A0 (en) | 1987-01-08 | 1988-06-30 | Int Genetic Eng | Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same |
JP3101690B2 (ja) | 1987-03-18 | 2000-10-23 | エス・ビィ・2・インコーポレイテッド | 変性抗体の、または変性抗体に関する改良 |
US4880078A (en) | 1987-06-29 | 1989-11-14 | Honda Giken Kogyo Kabushiki Kaisha | Exhaust muffler |
EP0534944B1 (en) | 1988-11-14 | 1996-09-11 | Brigham And Women's Hospital | Antibodies specific for elam-1 and the use thereof |
US5632991A (en) * | 1988-11-14 | 1997-05-27 | Brigham & Women's Hospital | Antibodies specific for E-selectin and the uses thereof |
US5081034A (en) | 1988-11-14 | 1992-01-14 | Brigham & Women's Hospital | Cloned genes which encode elam-1 |
US5272263A (en) | 1989-04-28 | 1993-12-21 | Biogen, Inc. | DNA sequences encoding vascular cell adhesion molecules (VCAMS) |
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AU666852B2 (en) | 1991-05-01 | 1996-02-29 | Henry M. Jackson Foundation For The Advancement Of Military Medicine | A method for treating infectious respiratory diseases |
WO1992022653A1 (en) | 1991-06-14 | 1992-12-23 | Genentech, Inc. | Method for making humanized antibodies |
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US6749853B1 (en) | 1992-03-05 | 2004-06-15 | Board Of Regents, The University Of Texas System | Combined methods and compositions for coagulation and tumor treatment |
WO1993017715A1 (en) | 1992-03-05 | 1993-09-16 | Board Of Regents, The University Of Texas System | Diagnostic and/or therapeutic agents, targeted to neovascular endothelial cells |
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JPH09512705A (ja) | 1994-03-29 | 1997-12-22 | セルテック セラピューティクス リミテッド | E−セレクチンに対する抗体 |
AU748561B2 (en) | 1994-06-07 | 2002-06-06 | Regents Of The University Of Minnesota | Methods for inhibiting antigen specific T cell responses |
JPH10501815A (ja) | 1994-06-07 | 1998-02-17 | リージェンツ・オブ・ザ・ユニバーシティ・オブ・ミネソタ | 抗原特異的t細胞応答の阻害方法 |
US5622701A (en) | 1994-06-14 | 1997-04-22 | Protein Design Labs, Inc. | Cross-reacting monoclonal antibodies specific for E- and P-selectin |
US6019968A (en) | 1995-04-14 | 2000-02-01 | Inhale Therapeutic Systems, Inc. | Dispersible antibody compositions and methods for their preparation and use |
WO1996040942A1 (en) * | 1995-06-07 | 1996-12-19 | Cytel Corporation | Humanized antibodies to e-selectin |
DK0885002T3 (da) | 1996-03-04 | 2011-08-22 | Penn State Res Found | Materialer og fremgangsmåder til forøgelse af cellulær internalisering |
US5985309A (en) | 1996-05-24 | 1999-11-16 | Massachusetts Institute Of Technology | Preparation of particles for inhalation |
US5874064A (en) | 1996-05-24 | 1999-02-23 | Massachusetts Institute Of Technology | Aerodynamically light particles for pulmonary drug delivery |
US5855913A (en) | 1997-01-16 | 1999-01-05 | Massachusetts Instite Of Technology | Particles incorporating surfactants for pulmonary drug delivery |
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US20160331775A1 (en) | 2015-05-14 | 2016-11-17 | The Regents Of The University Of Michigan | E-selectin inhibition works in combination with low-molecular weight heparin to decrease venous thrombosis and bleeding risk |
US10647756B2 (en) | 2015-05-18 | 2020-05-12 | Pfizer Inc. | Humanized antibodies |
WO2017151708A1 (en) | 2016-03-02 | 2017-09-08 | Glycomimetics, Inc. | Methods for the treatment and/or prevention of cardiovescular disease by inhibition of e-selectin |
US11014908B2 (en) | 2018-11-29 | 2021-05-25 | Pfizer Inc. | Chemical compounds |
CN112868090A (zh) | 2019-09-12 | 2021-05-28 | 铠侠股份有限公司 | 基板处理装置 |
-
2021
- 2021-01-21 PE PE2022001465A patent/PE20221902A1/es unknown
- 2021-01-21 KR KR1020227028674A patent/KR20220131293A/ko active Search and Examination
- 2021-01-21 JP JP2022544058A patent/JP7449390B2/ja active Active
- 2021-01-21 CA CA3168704A patent/CA3168704A1/en active Pending
- 2021-01-21 BR BR112022014417A patent/BR112022014417A2/pt unknown
- 2021-01-21 CN CN202180017139.5A patent/CN115190814A/zh active Pending
- 2021-01-21 MX MX2022009130A patent/MX2022009130A/es unknown
- 2021-01-21 US US17/154,588 patent/US11597770B2/en active Active
- 2021-01-21 WO PCT/IB2021/050464 patent/WO2021148983A1/en active Application Filing
- 2021-01-21 EP EP21701855.5A patent/EP4093508A1/en active Pending
- 2021-01-21 AU AU2021210669A patent/AU2021210669A1/en active Pending
- 2021-01-21 IL IL294921A patent/IL294921A/en unknown
- 2021-01-22 TW TW110102479A patent/TW202140558A/zh unknown
-
2022
- 2022-07-19 CO CONC2022/0010244A patent/CO2022010244A2/es unknown
-
2023
- 2023-02-27 US US18/174,974 patent/US20240076386A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
US20210246213A1 (en) | 2021-08-12 |
CA3168704A1 (en) | 2021-07-29 |
MX2022009130A (es) | 2022-08-22 |
KR20220131293A (ko) | 2022-09-27 |
JP7449390B2 (ja) | 2024-03-13 |
US20240076386A1 (en) | 2024-03-07 |
IL294921A (en) | 2022-09-01 |
EP4093508A1 (en) | 2022-11-30 |
CN115190814A (zh) | 2022-10-14 |
AU2021210669A1 (en) | 2022-08-18 |
CO2022010244A2 (es) | 2022-08-09 |
WO2021148983A1 (en) | 2021-07-29 |
BR112022014417A2 (pt) | 2022-09-13 |
JP2023503714A (ja) | 2023-01-31 |
US11597770B2 (en) | 2023-03-07 |
TW202140558A (zh) | 2021-11-01 |
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