DE69227618T2 - Die verwendung des leukozyten adhäsionsmolekül-1- aus endothelzellen und antikörper dagegen in der behandlung von asthma - Google Patents
Die verwendung des leukozyten adhäsionsmolekül-1- aus endothelzellen und antikörper dagegen in der behandlung von asthmaInfo
- Publication number
- DE69227618T2 DE69227618T2 DE69227618T DE69227618T DE69227618T2 DE 69227618 T2 DE69227618 T2 DE 69227618T2 DE 69227618 T DE69227618 T DE 69227618T DE 69227618 T DE69227618 T DE 69227618T DE 69227618 T2 DE69227618 T2 DE 69227618T2
- Authority
- DE
- Germany
- Prior art keywords
- elam
- asthma
- treatment
- antibodies against
- adhesion molecule
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 208000006673 asthma Diseases 0.000 title abstract 2
- KZMAWJRXKGLWGS-UHFFFAOYSA-N 2-chloro-n-[4-(4-methoxyphenyl)-1,3-thiazol-2-yl]-n-(3-methoxypropyl)acetamide Chemical compound S1C(N(C(=O)CCl)CCCOC)=NC(C=2C=CC(OC)=CC=2)=C1 KZMAWJRXKGLWGS-UHFFFAOYSA-N 0.000 title 1
- 102000015689 E-Selectin Human genes 0.000 abstract 8
- 108010024212 E-Selectin Proteins 0.000 abstract 8
- 239000012634 fragment Substances 0.000 abstract 4
- 239000000356 contaminant Substances 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/7056—Lectin superfamily, e.g. CD23, CD72
- C07K14/70564—Selectins, e.g. CD62
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2851—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
- C07K16/2854—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72 against selectins, e.g. CD62
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/06—Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- General Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Cell Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Mycology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Materials For Medical Uses (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US73863391A | 1991-07-31 | 1991-07-31 | |
PCT/US1992/006523 WO1993002702A1 (en) | 1991-07-31 | 1992-07-31 | Use of endothelial-leukocyte adhesion molecule-1 and antibodies thereto in the treatment of asthma |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69227618D1 DE69227618D1 (de) | 1998-12-24 |
DE69227618T2 true DE69227618T2 (de) | 1999-05-06 |
Family
ID=24968819
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69227618T Expired - Fee Related DE69227618T2 (de) | 1991-07-31 | 1992-07-31 | Die verwendung des leukozyten adhäsionsmolekül-1- aus endothelzellen und antikörper dagegen in der behandlung von asthma |
Country Status (12)
Country | Link |
---|---|
US (1) | US5843441A (de) |
EP (1) | EP0551501B1 (de) |
JP (1) | JPH06502195A (de) |
KR (1) | KR100252621B1 (de) |
AT (1) | ATE173503T1 (de) |
AU (1) | AU663332B2 (de) |
CA (1) | CA2083273A1 (de) |
DE (1) | DE69227618T2 (de) |
DK (1) | DK0551501T3 (de) |
ES (1) | ES2123570T3 (de) |
HU (1) | HU215549B (de) |
WO (1) | WO1993002702A1 (de) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU5911196A (en) * | 1995-06-13 | 1997-01-09 | Nisshin Oil Mills, Ltd., The | Antiasthmatic agent |
US6008203A (en) * | 1995-07-14 | 1999-12-28 | Glycotech Corp. | Methods for treatment of EGF receptor associated cancers |
US7247302B1 (en) * | 1996-08-02 | 2007-07-24 | Bristol-Myers Squibb Company | Method for inhibiting immunoglobulin-induced toxicity resulting from the use of immunoglobulins in therapy and in vivo diagnosis |
AU2002308628A1 (en) * | 2001-05-08 | 2002-11-18 | Blanchette Rockefeller Neurosciences Institute | Adenosine a1 receptor antagonists for treating hypoxia-induced learning and memory impairment |
MX2022009130A (es) * | 2020-01-24 | 2022-08-22 | Pfizer | Anticuerpos anti-e-selectina, composiciones y metodos de uso. |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE68927188T2 (de) * | 1988-11-14 | 1997-04-24 | Brigham & Womens Hospital | Antikörper, spezifisch gegen elam-1 sowie deren verwendung |
DK0387701T3 (da) * | 1989-03-09 | 1992-12-07 | Boehringer Ingelheim Pharma | Anvendelse af intercellulære adhæsionsmolekyler samt deres bindende ligander ved behandling af astma |
US5143712A (en) * | 1990-07-30 | 1992-09-01 | Glycomed Incorporated | Method of determining a site of inflammation utilizing elam-1 ligands |
-
1992
- 1992-07-31 EP EP92917640A patent/EP0551501B1/de not_active Expired - Lifetime
- 1992-07-31 JP JP5503829A patent/JPH06502195A/ja active Pending
- 1992-07-31 DE DE69227618T patent/DE69227618T2/de not_active Expired - Fee Related
- 1992-07-31 AU AU24410/92A patent/AU663332B2/en not_active Ceased
- 1992-07-31 ES ES92917640T patent/ES2123570T3/es not_active Expired - Lifetime
- 1992-07-31 DK DK92917640T patent/DK0551501T3/da active
- 1992-07-31 WO PCT/US1992/006523 patent/WO1993002702A1/en active IP Right Grant
- 1992-07-31 CA CA002083273A patent/CA2083273A1/en not_active Abandoned
- 1992-07-31 AT AT92917640T patent/ATE173503T1/de not_active IP Right Cessation
- 1992-07-31 HU HU9300928A patent/HU215549B/hu not_active IP Right Cessation
- 1992-07-31 KR KR1019930700797A patent/KR100252621B1/ko not_active IP Right Cessation
-
1995
- 1995-07-19 US US08/504,257 patent/US5843441A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
ATE173503T1 (de) | 1998-12-15 |
CA2083273A1 (en) | 1993-02-01 |
WO1993002702A1 (en) | 1993-02-18 |
HUT69623A (en) | 1995-09-28 |
KR930702025A (ko) | 1993-09-08 |
HU215549B (hu) | 1999-01-28 |
EP0551501B1 (de) | 1998-11-18 |
KR100252621B1 (ko) | 2000-09-01 |
ES2123570T3 (es) | 1999-01-16 |
DK0551501T3 (da) | 1999-08-02 |
AU2441092A (en) | 1993-03-02 |
EP0551501A1 (de) | 1993-07-21 |
DE69227618D1 (de) | 1998-12-24 |
US5843441A (en) | 1998-12-01 |
EP0551501A4 (en) | 1993-09-22 |
AU663332B2 (en) | 1995-10-05 |
HU9300928D0 (en) | 1993-06-28 |
JPH06502195A (ja) | 1994-03-10 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |